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Journal articles on the topic 'AB-CHMINACA'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Lefever, Timothy W., Julie A. Marusich, Brian F. Thomas, et al. "Vaping Synthetic Cannabinoids: A Novel Preclinical Model of E-Cigarette Use in Mice." Substance Abuse: Research and Treatment 11 (January 1, 2017): 117822181770173. http://dx.doi.org/10.1177/1178221817701739.

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Smoking is the most common route of administration for cannabis; however, vaping cannabis extracts and synthetic cannabinoids (“fake marijuana”) in electronic cigarette devices has become increasingly popular. Yet, most animal models used to investigate biological mechanisms underlying cannabis use employ injection as the route of administration. This study evaluated a novel e-cigarette device that delivers aerosolized cannabinoids to mice. The effects of aerosolized and injected synthetic cannabinoids (CP 55,940, AB-CHMINACA, XLR-11, and JWH-018) in mice were compared in a battery of bioassay

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Mousa, Rasha, Sahar Gebril, Khaled Masoud, Rania Radwan, and Soheir Mohammad. "A New Synthetic Cannabinoid Substance, AB-CHMINACA: Review Article." Sohag Medical Journal 25, no. 2 (2021): 84–92. http://dx.doi.org/10.21608/smj.2021.74742.1249.

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3

Maeda, Hideyuki, Ruri Kikura-Hanajiri, Maiko Kawamura, Erika Nagashima, and Ken-Ichi Yoshida. "AB-CHMINACA-induced sudden death from non-cardiogenic pulmonary edema." Clinical Toxicology 56, no. 2 (2017): 143–45. http://dx.doi.org/10.1080/15563650.2017.1340648.

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4

Erratico, Claudio, Noelia Negreira, Helia Norouzizadeh, et al. "In vitroandin vivohuman metabolism of the synthetic cannabinoid AB-CHMINACA." Drug Testing and Analysis 7, no. 10 (2015): 866–76. http://dx.doi.org/10.1002/dta.1796.

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5

Santos, Rita M. G., Rita Lima, Sara Cravo, Pedro Alexandrino Fernandes, Fernando Remião, and Carla Fernandes. "Binding Affinity of Synthetic Cannabinoids to Human Serum Albumin: Site Characterization and Interaction Insights." Pharmaceuticals 18, no. 4 (2025): 581. https://doi.org/10.3390/ph18040581.

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Background/Objectives: High-performance affinity chromatography (HPAC) was used to investigate the binding affinity of a series of synthetic cannabinoids, a widely abused class of new psychoactive substances, to human serum albumin (HSA) and obtain insights into the binding sites. To better understand the recognition mechanisms, molecular docking studies were conducted. Methods: Binding affinity was assessed through zonal elution approach Additionally, displacement chromatography with site-specific probes provided insights into the HSA binding sites of five synthetic cannabinoids. Results: Tha

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6

Brajković, G., V. Kilibarda, J. Jović-Stošić, et al. "Determination of AB-CHMINACA and it's carboxy metabolite in urine samples." Toxicology Letters 238, no. 2 (2015): S153. http://dx.doi.org/10.1016/j.toxlet.2015.08.477.

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7

Peterson, Brianna L., and Fiona J. Couper. "Concentrations of AB-CHMINACA and AB-PINACA and Driving Behavior in Suspected Impaired Driving Cases." Journal of Analytical Toxicology 39, no. 8 (2015): 642–47. http://dx.doi.org/10.1093/jat/bkv091.

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8

Brajković, G. S., J. Jović Stošić, S. Đorđević, et al. "UPLC/MS determination of AB-FUBINACA, AB-CHMINACA and MDMB-CHMICA metabolites in urine samples." Toxicology Letters 258 (September 2016): S102. http://dx.doi.org/10.1016/j.toxlet.2016.06.1434.

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9

Navarro-Tapia, Elisabet, Jana Codina, Víctor José Villanueva-Blasco, Óscar García-Algar, and Vicente Andreu-Fernández. "Detection of the Synthetic Cannabinoids AB-CHMINACA, ADB-CHMINACA, MDMB-CHMICA, and 5F-MDMB-PINACA in Biological Matrices: A Systematic Review." Biology 11, no. 5 (2022): 796. http://dx.doi.org/10.3390/biology11050796.

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New synthetic cannabinoids (SCs) are emerging rapidly and continuously. Biological matrices are key for their precise detection to link toxicity and symptoms to each compound and concentration and ascertain consumption trends. The objective of this study was to determine the best human biological matrices to detect the risk-assessed compounds provided by The European Monitoring Centre for Drugs and Drug Addiction: AB-CHMINACA, ADB-CHMNACA, MDMB-CHMICA, and 5F-MDMB-PINACA. We carried out a systematic review covering 2015 up to the present date, including original articles assessing detection in

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10

Tyndall, Joseph A., Roy Gerona, Giuliano De Portu, et al. "An outbreak of acute delirium from exposure to the synthetic cannabinoid AB-CHMINACA." Clinical Toxicology 53, no. 10 (2015): 950–56. http://dx.doi.org/10.3109/15563650.2015.1100306.

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11

Hvozdovich, Jessica A., Chris W. Chronister, Barry K. Logan, and Bruce A. Goldberger. "Case Report: Synthetic Cannabinoid Deaths in State of Florida Prisoners." Journal of Analytical Toxicology 44, no. 3 (2020): 298–300. http://dx.doi.org/10.1093/jat/bkz092.

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Abstract Between March 2017 and November 2018, 54 prisoner fatal overdose cases submitted to the University of Florida Forensic Toxicology Laboratory involved synthetic cannabinoids including 5F-ADB, FUB-AMB, 5F-AMB, MDMB-FUBINACA and AB-CHMINACA. Analysis of blood and urine samples was performed at NMS Labs (Horsham, PA) by liquid chromatography/tandem mass spectrometry screening, confirmatory and quantitative methods validated according to Scientific Working Group for Forensic Toxicology guidelines. This work highlights the importance of effective communication between toxicologists and medi

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12

Longworth, Mitchell, Samuel D. Banister, James B. C. Mack, Michelle Glass, Mark Connor, and Michael Kassiou. "The 2-alkyl-2H-indazole regioisomers of synthetic cannabinoids AB-CHMINACA, AB-FUBINACA, AB-PINACA, and 5F-AB-PINACA are possible manufacturing impurities with cannabimimetic activities." Forensic Toxicology 34, no. 2 (2016): 286–303. http://dx.doi.org/10.1007/s11419-016-0316-y.

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13

Mousa, Rasha, Sahar Gebri, Khaled Masoud, Rania Radwan, and Soheir Mohamad. "Acute Toxic Effects of AB-CHMINACA on Lung, Heart and Liver: An Experimental Pilot Study." Ain Shams Journal of Forensic Medicine and Clinical Toxicology 37, no. 2 (2021): 128–35. http://dx.doi.org/10.21608/ajfm.2021.182715.

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14

Wurita, Amin, Koutaro Hasegawa, Kayoko Minakata, et al. "Identification and quantification of metabolites of AB-CHMINACA in a urine specimen of an abuser." Legal Medicine 19 (March 2016): 113–18. http://dx.doi.org/10.1016/j.legalmed.2015.07.011.

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15

Angerer, V., S. Jacobi, F. Franz, V. Auwärter, and J. Pietsch. "Three fatalities associated with the synthetic cannabinoids 5F-ADB, 5F-PB-22, and AB-CHMINACA." Forensic Science International 281 (December 2017): e9-e15. http://dx.doi.org/10.1016/j.forsciint.2017.10.042.

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16

Hermanns-Clausen, Maren, Dieter Müller, Josephine Kithinji, et al. "Acute side effects after consumption of the new synthetic cannabinoids AB-CHMINACA and MDMB-CHMICA." Clinical Toxicology 56, no. 6 (2017): 404–11. http://dx.doi.org/10.1080/15563650.2017.1393082.

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17

Wiley, Jenny L., Julie A. Marusich, Timothy W. Lefever та ін. "AB-CHMINACA, AB-PINACA, and FUBIMINA: Affinity and Potency of Novel Synthetic Cannabinoids in Producing Δ9-Tetrahydrocannabinol–Like Effects in Mice". Journal of Pharmacology and Experimental Therapeutics 354, № 3 (2015): 328–39. http://dx.doi.org/10.1124/jpet.115.225326.

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18

Romańczuk, Agnieszka, Sebastian Rojek, Karol Kula, and Małgorzata Kłys. "Aspects related to analysis and medico-legal assessment in the context of the presence of synthetic cannabinoids in biological material based on the example of AB-CHMINACA." Archives of Forensic Medicine and Criminology 68, no. 4 (2018): 266–80. http://dx.doi.org/10.5114/amsik.2018.84530.

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19

Sim, Juhyun, Han Soo Cho, Jaesin Lee, Sangwhan In, and Eunmi Kim. "Determination of AB-CHMINACA and its metabolites in human hair and their deposition in hair of abusers." Journal of Pharmaceutical and Biomedical Analysis 140 (June 2017): 162–68. http://dx.doi.org/10.1016/j.jpba.2017.03.041.

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20

Vučinić, Slavica, Vesna Kilibarda, Snežana Đorđević, et al. "Clinical and analytical experience of the National Poison Control Centre with synthetic cannabinoids." Archives of Industrial Hygiene and Toxicology 69, no. 2 (2018): 178–85. http://dx.doi.org/10.2478/aiht-2018-69-3096.

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AbstractA rising number of patients are being treated for overdosing with new psychoactive substances (NPS) available at the illegal drug market in Serbia. The aim of this study was to report clinical and analytical experience of the National Poison Control Centre of Serbia (NPCC) with synthetic cannabinoids (SCs) and point to the NPS available at the illegal drug market in our country. From January 2013 to December 2016, 58 patients (aged between 14 and 25) were treated for the effects of synthetic cannabinoids at the NPCC. Tachycardia was established in 53, mydriasis in 31, somnolence, nause

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21

Klavž, Janez, Maksimiljan Gorenjak, and Martin Marinšek. "Suicide attempt with a mix of synthetic cannabinoids and synthetic cathinones: Case report of non-fatal intoxication with AB-CHMINACA, AB-FUBINACA, alpha-PHP, alpha-PVP and 4-CMC." Forensic Science International 265 (August 2016): 121–24. http://dx.doi.org/10.1016/j.forsciint.2016.01.018.

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22

Costain, Willard J., Ingrid Rasquinha, Tanya Comas, et al. "Analysis of the pharmacological properties of JWH-122 isomers and THJ-2201, RCS-4 and AB-CHMINACA in HEK293T cells and hippocampal neurons." European Journal of Pharmacology 823 (March 2018): 96–104. http://dx.doi.org/10.1016/j.ejphar.2018.01.043.

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23

de Oliveira, Mariana Campello, Mariana Capelo Vides, Dângela Layne Silva Lassi, et al. "Toxicity of Synthetic Cannabinoids in K2/Spice: A Systematic Review." Brain Sciences 13, no. 7 (2023): 990. http://dx.doi.org/10.3390/brainsci13070990.

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(1) Background: Synthetic cannabinoids (SCs) are emerging drugs of abuse sold as ‘K2’, ‘K9’ or ‘Spice’. Evidence shows that using SCs products leads to greater health risks than cannabis. They have been associated with greater toxicity and higher addiction potential unrelated to the primary psychoactive component of marijuana, Δ9-tetrahydrocannabinol (Δ9-THC). Moreover, early cases of intoxication and death related to SCs highlight the inherent danger that may accompany the use of these substances. However, there is limited knowledge of the toxicology of Spice ingredients. This systematic revi

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24

Hasegawa, Koutaro, Amin Wurita, Kayoko Minakata, et al. "Postmortem distribution of AB-CHMINACA, 5-fluoro-AMB, and diphenidine in body fluids and solid tissues in a fatal poisoning case: usefulness of adipose tissue for detection of the drugs in unchanged forms." Forensic Toxicology 33, no. 1 (2014): 45–53. http://dx.doi.org/10.1007/s11419-014-0245-6.

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25

Uchiyama, Nahoko, Yoshihiko Shimokawa, Ruri Kikura-Hanajiri, Yosuke Demizu, Yukihiro Goda та Takashi Hakamatsuka. "A synthetic cannabinoid FDU-NNEI, two 2H-indazole isomers of synthetic cannabinoids AB-CHMINACA and NNEI indazole analog (MN-18), a phenethylamine derivative N–OH-EDMA, and a cathinone derivative dimethoxy-α-PHP, newly identified in illegal products". Forensic Toxicology 33, № 2 (2015): 244–59. http://dx.doi.org/10.1007/s11419-015-0268-7.

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26

Cannaert, Annelies, Eric Sparkes, Edward Pike, et al. "Synthesis and in Vitro Cannabinoid Receptor 1 Activity of Recently Detected Synthetic Cannabinoids 4F-MDMB-BICA, 5F-MPP-PICA, MMB-4en-PICA, CUMYL-CBMICA, ADB-BINACA, APP-BINACA, 4F-MDMB-BINACA, MDMB-4en-PINACA, A-CHMINACA, 5F-AB-P7AICA, 5F-MDMB-P7AICA, and 5F-AP7AICA." ACS Chemical Neuroscience 11, no. 24 (2020): 4434–46. http://dx.doi.org/10.1021/acschemneuro.0c00644.

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27

Mohammad, Soheir Ali, Rasha Elhaddad Ali Mousa, Sahar Mohamed Gebril, Khaled Masoud Mohamed Masoud, and Rania Ahmad Radwan. "Toxic effects of AB-CHMINACA on liver and kidney and detection of its blood level in adult male mice." Forensic Toxicology, August 13, 2023. http://dx.doi.org/10.1007/s11419-023-00670-0.

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Abstract Background AB-CHMINACA is a cannabimimetic indazole derivative. In 2013, it was reported in different countries as a substance of abuse. Purpose This study evaluated the subacute toxic effects of AB-CHMINACA on the liver and kidneys and measured its blood level in adult male mice. Methods The histological and biochemical subacute toxic effects on the liver and kidneys were assessed after four weeks of daily intraperitoneal injections of one of the following doses: 0.3 mg/kg, 3 mg/kg, or 10 mg/kg as the highest dose in adult male albino mice. In addition, the blood concentration level

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28

Wagmann, Lea, Rebecca G. Stiller, Svenja Fischmann, Folker Westphal, and Markus R. Meyer. "Going deeper into the toxicokinetics of synthetic cannabinoids: in vitro contribution of human carboxylesterases." Archives of Toxicology, July 5, 2022. http://dx.doi.org/10.1007/s00204-022-03332-z.

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AbstractSynthetic cannabinoids (SC) are new psychoactive substances known to cause intoxications and fatalities. One reason may be the limited data available concerning the toxicokinetics of SC, but toxicity mechanisms are insufficiently understood so far. Human carboxylesterases (hCES) are widely known to play a crucial role in the catalytic hydrolysis of drugs (of abuse). The aim of this study was to investigate the in vitro contribution of hCES to the metabolism of the 13 SC 3,5-AB-5F-FUPPYCA, AB-5F-P7AICA, A-CHMINACA, DMBA-CHMINACA, MBA-CHMINACA, MDMB-4F-BINACA, MDMB-4en-PINACA, MDMB-FUBIC

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29

Navarro-Tapia, Elisabet, Jana Codina, Víctor José Villanueva-Blasco, Óscar García-Algar, and Vicente Andreu-Fernández. "Detection of the Synthetic Cannabinoids AB-CHMINACA, ADB-CHMINACA, MDMB-CHMICA, and 5F-MDMB-PINACA in Biological Matrices: A Systematic Review." Biology-Basel, May 23, 2022. https://doi.org/10.3390/biology11050796.

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New synthetic cannabinoids (SCs) are emerging rapidly and continuously. Biological matrices are key for their precise detection to link toxicity and symptoms to each compound and concentration and ascertain consumption trends. The objective of this study was to determine the best human biological matrices to detect the risk-assessed compounds provided by The European Monitoring Centre for Drugs and Drug Addiction: AB-CHMINACA, ADB-CHMNACA, MDMBCHMICA, and 5F-MDMB-PINACA. We carried out a systematic review covering 2015 up to the present date, including original ar

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30

Lobato-Freitas, Carolina, Helena Carmo, Félix Carvalho, João Pedro Silva, and Diana Dias da Silva. "AMB-Fubinaca, AB-Chminaca and HU-308’s effects on in vitro differentiation and proliferation of NG108-15 cells." RevSALUS - Revista Científica da Rede Académica das Ciências da Saúde da Lusofonia 4, Sup (2022). http://dx.doi.org/10.51126/revsalus.v4isup.369.

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31

Musile, Giacomo, Covadonga Palacio, Matilde Murari, Svetlana Appolonova, and Franco Tagliaro. "Development and Validation of a Rapid Method for Identification of New Synthetic Cannabinoids in Hair Based on High-Performance Liquid Chromatography-Ion Trap Mass Spectrometry Using a Simplified User-Interface." Journal of Analytical Toxicology, May 10, 2022. http://dx.doi.org/10.1093/jat/bkac027.

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Abstract The penetration of the new psychoactive substances (NPS) into the market of clandestine drugs is highly dynamic. This hampers the effectiveness of the current analytical instrumentation, particularly in the screening phase, which potentially false-negative results. At present, the suggested approach to perform a comprehensive screening requires the use of high-resolution mass spectrometry (HRMS) with associated high costs of purchase and maintenance, and need of skilled and dedicated personnel. Here we describe the development and validation of a simplified approach based on a high-pe

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32

Sim, Sui Boon Derek, Hui Zhi Shirley Lee, Mei Ching Ong, et al. "Synthesis, characterization and differentiation of the structural isomers of valine and tert‐leucine derived synthetic cannabinoids." Drug Testing and Analysis, August 12, 2023. http://dx.doi.org/10.1002/dta.3561.

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AbstractThe identification of the synthetic cannabinoids receptor agonists (SCRAs) has always posed a great challenge to drug testing laboratories with slight structural modifications aimed at evading drug legislation. In addition, the most prevalent synthetic cannabinoids have valine and tert‐leucine amino acid moieties where re‐arrangement of the carbon chains can result in structural isomers that are very similar to the parent synthetic cannabinoids. This makes their analysis and identification challenging, and the problem is compounded with the difficulty in purchasing reference standards

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33

Monti, Manuela Carla, Tobias Rautio, Marie H. Deventer, et al. "Tail-less precursors in synthetic cannabinoid production: investigating a clandestine laboratory, seized samples, and CB1 activity." Archives of Toxicology, May 23, 2025. https://doi.org/10.1007/s00204-025-04086-0.

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Abstract An emerging new trend reveals that potent synthetic cannabinoid receptor agonists (SCRAs) that were prevalent prior to the Chinese class-wide ban in July 2021 have remained on the market or re-emerged. This is likely because of a new production route where unscheduled tail-less precursors are converted into the desired controlled SCRA via a one-step synthesis. This study reports the discovery of a clandestine production site in Switzerland for this synthesis. Controlled recreations of the synthesis of ADB-BUTINACA (also known as ADB-BINACA or ADMB-BUTINACA) and MDMB-4en-PINACA based o

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34

Kądzioła-Długołęcka, Kinga, Oliwia Frączak, Beata Tkacz-Szczęsna, et al. "The paths of syntheses, chemical characteristics and stability tests for selected synthetic cannabinoids: 5F-PB-22, NM-2201, UR-144, and AB-CHMINACA." Australian Journal of Forensic Sciences, September 8, 2019, 1–12. http://dx.doi.org/10.1080/00450618.2019.1661515.

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35

AL-Eitan, Laith, and Hana Abu Kharmah. "The Effect of the Synthetic Cannabinoid AB-CHMINACA on the Roles of Vascular Endothelial Growth Factor, Angiopoietin-1, and Angiopoietin-2 in Brain Angiogenesis." Applied In Vitro Toxicology, September 6, 2023. http://dx.doi.org/10.1089/aivt.2023.0003.

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36

Groth, Olwen, Gabriele Roider, Verena Angerer, et al. "“Spice”-related deaths in and around Munich, Germany: A retrospective look at the role of synthetic cannabinoid receptor agonists in our post-mortem cases over a seven-year period (2014–2020)." International Journal of Legal Medicine, April 19, 2023. http://dx.doi.org/10.1007/s00414-023-02995-2.

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Abstract Synthetic cannabinoid receptor agonists (SCRAs, “Spice”) are a diverse group of recreational drugs, with their structural and pharmacological variability still evolving. Forensic toxicologists often rely on previous reports to assess their role in intoxication cases. This work provides detailed information on the “Spice”-related fatalities around Munich, Germany, from 2014 to 2020. All cases underwent an autopsy. Pharmaceutical and illicit drugs were detected and quantified in post-mortem peripheral blood or liver by liquid chromatography-tandem mass spectrometry (LC–MS/MS). Based on

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37

Gish, Alexandr, Véronique Dumestre-Toulet, Camille Richeval, et al. "Trends in pharmaceutical design of new psychoactive substances detected in oral fluid of drivers around a music festival in south-west France: comparison 2019/2017." Current Pharmaceutical Design 28 (May 17, 2022). http://dx.doi.org/10.2174/1381612828666220517160545.

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Objective: new psychoactive substance use (NPS) is a reality in France, including among drivers. This work aims (i) to report pharmaceutical design of NPS detected in oral fluid (OF) from drivers initially screened for drugs around a music festival in 2019, and (ii) to compare obtained results with those of a previous similar study carried out in 2017 in the same situation (and the same music festival) and according to the same methodology. Methods: OF specimens were recovered from the used devices of the salivary immunochemical tests used by the police during the controls carried out at the e

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