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Journal articles on the topic 'Abbott Alinity ci® analyze'

Author: Grafiati
Published: 7 June 2025
Last updated: 17 July 2025

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1

Issam, Mokhtari, Elkhamlichi Imad-Eddine, Kajeiou Zainab, et al. "Verification of the analytical performance of the serum glucose assay on the Abbott Alinity ci®." GSC Biological and Pharmaceutical Sciences 24, no. 3 (2023): 068–74. https://doi.org/10.5281/zenodo.10441659.

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The precision and reliability of the serum glucose assay on the Abbott Alinity ci® analyzer were systematically evaluated. The study was conducted over 30 days in the biochemistry laboratory of Mohammed VI University Hospital. Two phases were carried out: reproducibility assessment involving daily measurements across low, medium, and high glucose levels, and repeatability testing involving 30 replicates per sample. The hexokinase enzymatic approach was employed for glucose quantification. Data analysis utilized the BYG middleware and complied with FSCB and RICOS standards. For reproducibility, the coefficient of variation (CV) values were low, ranging from 1.49% to 1.84%. Repeatability CV values were even lower, varying from 0.34% to 0.94%. Results aligned well with quality control limits, confirming the assay's consistency and precision. This study underscores the robustness and reliability of the hexokinase method on the Alinity ci® platform for serum glucose analysis, with implications for accurate patient care. By adhering to strict analytical performance verification, laboratories ensure dependable clinical outcomes. This research contributes to the foundation of knowledge supporting serum glucose measurement reliability.
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2

Sohaib El kandouni, Dounia El Moujtahide, El Houcine Sebbar, and Mohammed Choukri. "Verification of the analytical performance of the urine ecstasy immunoassay on the Abbott Alinity ci ®." GSC Biological and Pharmaceutical Sciences 30, no. 2 (2025): 289–93. https://doi.org/10.30574/gscbps.2025.30.2.0051.

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The precision and reliability of the urine cannabinoids immunoassay on the Abbott Alinity ci® analyzer were systematically evaluated over 30 days in the biochemistry laboratory of Mohammed VI University Hospital. The study consisted of two phases: reproducibility assessment, involving daily measurements at low and high cannabinoid concentrations, and repeatability testing, with 30 replicates per sample. Cannabinoid quantification was performed using a homogeneous immunoenzymatic assay, with data analysis conducted via the BYG middleware, following the manufacturer's guidelines. The coefficient of variation (CV) for reproducibility ranged from 2.6% to 3.1%, while repeatability CV values varied between 2.8% and 3.7%, all within quality control limits, confirming the assay’s high precision and reliability. These findings underscore the robustness of the Alinity ci® platform for urine cannabinoid analysis, ensuring accurate and reproducible results critical for clinical and forensic applications. By adhering to rigorous analytical performance verification protocols, laboratories can ensure dependable and clinically meaningful outcomes, reinforcing the reliability of urine cannabinoid testing methodologies.
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3

Issam Mokhtari, Imad-Eddine Elkhamlichi, Zainab Kajeiou, et al. "Verification of the analytical performance of the serum glucose assay on the Abbott Alinity ci®." GSC Biological and Pharmaceutical Sciences 24, no. 3 (2023): 068–74. http://dx.doi.org/10.30574/gscbps.2023.24.3.0371.

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The precision and reliability of the serum glucose assay on the Abbott Alinity ci® analyzer were systematically evaluated. The study was conducted over 30 days in the biochemistry laboratory of Mohammed VI University Hospital. Two phases were carried out: reproducibility assessment involving daily measurements across low, medium, and high glucose levels, and repeatability testing involving 30 replicates per sample. The hexokinase enzymatic approach was employed for glucose quantification. Data analysis utilized the BYG middleware and complied with FSCB and RICOS standards. For reproducibility, the coefficient of variation (CV) values were low, ranging from 1.49% to 1.84%. Repeatability CV values were even lower, varying from 0.34% to 0.94%. Results aligned well with quality control limits, confirming the assay's consistency and precision. This study underscores the robustness and reliability of the hexokinase method on the Alinity ci® platform for serum glucose analysis, with implications for accurate patient care. By adhering to strict analytical performance verification, laboratories ensure dependable clinical outcomes. This research contributes to the foundation of knowledge supporting serum glucose measurement reliability.
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4

Sohaib El kandouni, Dounia El Moujtahide, El Houcine Sebbar, and Mohammed Choukri. "Verification of the analytical performance of the urine cannabinoids immunoassay on the Abbott Alinity ci ®." GSC Biological and Pharmaceutical Sciences 30, no. 2 (2025): 294–99. https://doi.org/10.30574/gscbps.2025.30.2.0056.

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The precision and reliability of the urine cannabinoids assay on the Abbott Alinity ci® analyzer were systematically evaluated. The study was conducted over 30 days in the biochemistry laboratory of Mohammed VI University Hospital. Two phases were carried out: reproducibility assessment involving daily measurements across low and high cannabinoid levels, and repeatability testing involving 30 replicates per sample. A homogeneous immunoenzymatic approach was employed for cannabinoid quantification. Data analysis utilized the BYG middleware and adhered to the manufacturer standards. For reproducibility, the coefficient of variation (CV) values were low, ranging from 2,6% to 3,1%. Repeatability CV values were also low, varying from 2,8% to 3,7%. Results were consistent with quality control limits, confirming the assay's precision and reliability. This study highlights the robustness of the immunoenzymatic method on the Alinity ci® platform for urine cannabinoid analysis, with significant implications for accurate patient care. By adhering to stringent analytical performance verification protocols, laboratories ensure dependable and clinically meaningful outcomes. This research contributes to the foundational knowledge supporting the reliability of urine cannabinoid measurement methodologies.
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5

Anouar M. Bouabdellah, Nada Benaini, Dounia El Moujtahide, El Houcine Sebbar, and Mohammed Choukri. "Verification of analytical performance of cyclosporine assay on the Abbott Alinity ci® at the biochemistry laboratory of Mohammed VI university hospital Oujda." GSC Biological and Pharmaceutical Sciences 30, no. 3 (2025): 168–73. https://doi.org/10.30574/gscbps.2025.30.3.0110.

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In medical laboratories, the verification of methods ensures precise measurements, complying with regulatory standards like the Moroccan Guide for Medical Laboratory Analysis (GBEA) and ISO 15189. After organ transplantation, blood levels of cyclosporine are often monitored closely, and its dosage adjusted accordingly to maintain therapeutic levels while minimizing the risk of toxicity. This study aims to verify the analytical performance of the cyclosporine assay on the Abbott Alinity ci® analyzer. Conducted at Mohammed VI university hospital’s biochemistry laboratory over 30 days, it involved two phases: evaluation of reproducibility and repeatability. Reproducibility was assessed by daily testing of the control samples at three concentration levels (low, medium, and high), and repeatability was measured by subjecting each serum sample to 30 individual assay runs. Cyclosporine determination used a dedicated reagent kit on the Abbott Alinity ci® analyzer’s immunology module, with data processing via the BYG middleware. The resulting coefficient of variation (CV) values were compared against standards set by the supplier. The investigation demonstrated a commendable repeatability across all concentration levels, with CV values of 3.59%, 3.23%, and 3.46% respectively. Intermediate fidelity examination yielded satisfactory results, with CV values of 3%, 4.83%, and 6.01% for low, medium, and high levels respectively. In conclusion, our study confirms the laboratory’s capability to provide accurate and precise cyclosporine assay results for clinical use, meeting the recommended criteria set by the suppliers.
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6

Kanani, Fatima Zehra, Adnan Haider Kazmi, and Bushra Kaleem. "Sigma metrics of Alinity ci system – a study on thirty-nine clinical chemistry and immunoassay parameters." Advances in Laboratory Medicine / Avances en Medicina de Laboratorio 2, no. 2 (2021): 267–75. http://dx.doi.org/10.1515/almed-2021-0001.

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Abstract Objectives Sigma metrics in an invaluable and inexpensive tool used in laboratories to monitor analytical quality of the assays. Alinity ci platform is a relatively recent analytical system launched by Abbott Diagnostics, and as such performance studies on it are few. We have calculated sigma metrics of 39 clinical chemistry and immunoassay analytes on two Alinity ci systems. Methods Sigma metrics were calculated using results of method validation studies. Coefficient of variation (CV) was calculated according to CLSI EP 15 guidelines. Bias was calculated using three different methods i.e., proficiency testing material, alternate method comparison with existent analyzers and linearity experiment. Total allowable error limits were kept similar to or less than the ones used in reference studies. Results All analytes except blood urea nitrogen (BUN) demonstrated greater than six sigma value across one or more levels and methods. No analyte amongst clinical chemistry and immunoassays was at below three sigma class. Amongst electrolytes, sodium was below three sigma class at two levels by proficiency testing method, although it was above four sigma class by other two methods. Sigma levels obtained were comparable to those reported in previously published studies. Conclusions Acceptable sigma metrics were achieved for all clinical chemistry, immunoassays and electrolytes on Alinity ci. Sigma metrics is an objective and well established cost effective tool to tailor internal quality control practices. This study determines sigma metrics for a wide range of high throughput assays. Long term assay performance needs to be monitored.
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7

Ismail, Faiz, Rhoubi Asmae, El Moujtahide Dounia, Houcine Sebbar El, and Choukri Mohammed. "Verification of the analytical performance of ASO (AntiStreptolysin O) Assay on the Abbott Alinity ci®: Experience of the Biochemistry laboratory of Mohammed VI University Hospital in Oujda/Morocco." GSC Biological and Pharmaceutical Sciences 29, no. 2 (2024): 042–46. https://doi.org/10.5281/zenodo.14738474.

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ASO (AntiStreptolysin O) is an antibody directed against streptolysin O which is an exotoxin secreted by&nbsp;<em>Streptococcus pyogenes</em>. The assay is mainly used for the diagnosis of post-streptococcal complications (AAR, nephropathy, etc.), False positives may be observed in cases of hyperlipemic serum, or liver disease. The objective of our work is to evaluate the analytical performance of the ASO assay on the Abbott Alinity ci&reg; at the Biochemistry laboratory of the Mohammed VI University Hospital in Oujda. The methodology of this work is based on the evaluation of reproducibility and repeatability, based on the technical accreditation guide (SH GTA 04) of the French Accreditation Committee (COFRAC). The results obtained for the different ASO dosage verification criteria show satisfactory repeatability for both levels (1: low / 2: medium), Intra-laboratory reproducibility was also satisfactory for both levels. By comparing these results with the CV used by the CLSI, we see that the results are consistent with and below the tolerated limits. This study shows that the Biochemistry laboratory of the Mohammed VI University Hospital in Oujda is able to provide accurate and precise results which regards with the requirements of learned societies for the determination of ASO.
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8

Harley, Kellisha, and Ian L. Gunsolus. "Comparison of the Clinical Performances of the Abbott Alinity IgG, Abbott Architect IgM, and Roche Elecsys Total SARS-CoV-2 Antibody Assays." Journal of Clinical Microbiology 59, no. 1 (2020): e02104-20. http://dx.doi.org/10.1128/jcm.02104-20.

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ABSTRACTCritical evaluation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serologic assays is needed to guide clinical decision-making and ensure that these assays provide optimal benefit to patients and the public. Here, three commercially available assays with widespread distribution capabilities are compared. A total of 667 specimens, 103 from patients with confirmed SARS-CoV-2 infections and 564 collected prior to the emergence of SARS-CoV-2, were analyzed in parallel using the Roche Elecsys SARS-CoV-2 total antibody and Abbott Alinity SARS-CoV-2 IgG assays; a subset of 55 samples from patients with confirmed SARS-CoV-2 infections was additionally evaluated using the Abbott Architect SARS-CoV-2 IgM assay. Qualitative agreement between the Abbott IgG and Roche total antibody assays was 98.7% (658/667), with Cohen’s kappa value of 0.919 (95% confidence interval [CI], 0.867 to 0.972). Qualitative agreements with the Abbott IgM assay were 92.7% (51/55, Abbott IgG) and 85.5% (47/55, Roche total antibody). Diagnostic specificities determined using pre-COVID-19 samples for the Abbott IgG and Roche total antibody assays were 99.65% (95% CI, 98.72 to 99.90%) and 100.00% (95% CI, 99.32 to 100.00%), respectively, spanning claims made by each manufacturer. Diagnostic sensitivities increased for all three assays with increasing time since the onset of symptoms. Among 51 patients with confirmed SARS-CoV-2 infections, 23 (45.1%), 24 (47.1%), and 22 (43.1%) were reactive by the Abbott IgG, Roche total antibody, and Abbott IgM assays, respectively, with sampling times 0 to 56 days post-positive PCR (median/mean, 2/6.2 days). Combining IgG and IgM screening identified 4/55 additional samples with detectable antibodies that would not have been observed using the assays independently. Notably, one immunocompromised patient with confirmed SARS-CoV-2 infection showed no detectable antibodies using any of the three assays 43 days after onset of symptoms.
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9

Imane Douichi, Asmae Kidoun, Kaoutar Jamal, et al. "Verification of the analytical performance of free triiodothyronine on ALINITY ci ® experience from the biochemistry laboratory of Mohammed VI University Hospital in Oujda." World Journal of Biology Pharmacy and Health Sciences 21, no. 2 (2025): 351–57. https://doi.org/10.30574/wjbphs.2025.21.2.0147.

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The verification of analytical methods is a requirement outlined by the International Organization for Standardization (ISO). This process involves evaluating the performance of an analytical method according to a well-defined protocol and comparing it with pre-established analytical objectives. In our study, we conducted an evaluation of the analytical performance of the free triiodothyronine (FT3) assay using the Abbott kit on the Alinity ci® analyzer in the biochemistry laboratory of Mohammed VI University Hospital in Oujda. The methodology adhered to the recommendations of the French accreditation committee (COFRAC) technical guide SH GTA 04, focusing on the assessment of repeatability and reproducibility. The results demonstrated excellent precision across low, medium, and high FT3 concentrations, with coefficients of variation (CV) within acceptable limits. These findings confirm the reliability of the Alinity ci® system for FT3 measurement, supporting its use in clinical diagnostics. It is important to note that the accuracy and reliability of examination results depend not only on laboratory personnel, equipment, and environmental conditions but also on the methods utilized and their validation or verification.
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10

Kaoutar Jamal, Oumaima kharkhach, Hasna Lekfif, Dounia El Moujtahide, El-Houcine Sebbar, and Mohammed Choukri. "Verification of the Analytical Performance of the Serum Lipoprotein (a) Assay on the Abbott Alinity ci®: Experience of the Biochemistry Laboratory at Mohammed VI University Hospital of Oujda." GSC Biological and Pharmaceutical Sciences 30, no. 3 (2025): 077–82. https://doi.org/10.30574/gscbps.2025.30.3.0092.

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The verification of analytical methods, as required by the ISO 15189 standard, allows for the evaluation and comparison of a method’s performance against predefined analytical objectives. This study focuses on verifying the assay of Lipoprotein (a) on the Abbott® Alinity analyzer, contributing to accreditation and quality improvement in the laboratory. The assay was performed using immunoturbidimetry. The evaluation of analytical performance (repeatability and intermediate precision) was conducted using two quality control levels, with results analyzed via BYG Informatique software. The obtained results show satisfactory repeatability with CV1 = 1.16% and CV2 = 0.44%. Intra-laboratory reproducibility is also satisfactory, with CV1 = 2.16% and CV2 = 1.29%, in line with the manufacturer's specifications.
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11

Asmae Rhoubi, Ismail Faiz, fatima zahra Joudar, El Houcine Sebbar, Dounia El Moujtahid, and Mohamed Choukri. "Reliability of PSA assays: A key asset for early prostate cancer detection." GSC Biological and Pharmaceutical Sciences 30, no. 2 (2025): 001–6. https://doi.org/10.30574/gscbps.2025.30.2.0043.

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Introduction: Prostate cancer requires early detection to reduce mortality, with PSA serving as a key marker since 1987. This assay, crucial for distinguishing benign conditions from cancer, requires rigorous precision in the laboratory. The aim of this study was to verify the method of PSA measurement in the biochemistry laboratory of the CHU Mohammed VI d'Oujda. Materials and methods: This prospective study, conducted at the CHU Mohammed VI d'Oujda over 30 days, assessed the reliability of total and free PSA measurements on the Abbott Alinity ci® analyzer. It assessed reproducibility through multi-operator tests and repeatability through consecutive analyses of standardized samples. The CMIA method enabled rigorous quantitative measurement, with analysis of coefficients of variation compared to CLSI standards to guarantee precision and accuracy, validated by intermediate management software. Results: The study assessed the repeatability and reproducibility of total and free PSA assays at different concentration levels. The results indicate that the majority of values fall within the acceptable range of variation ([-1S, 1S]), although minor variations were observed depending on levels and handling conditions. These results confirm the accuracy of the assay methods and underline their reliability for robust clinical analyses. Discussion and conclusion: Our results demonstrate good repeatability and reproducibility of tPSA and fPSA assays on Abbott's Alinity ci® analyzer, in line with performance standards established in the literature.
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12

Zaïnab, Kajeiou, Mokhtari Issam, Yacoubi Loubna, et al. "Verification of the analytical performance of the serum Folate assay on the Abbott Alinity ci®." GSC Biological and Pharmaceutical Sciences 26, no. 2 (2024): 199–205. https://doi.org/10.5281/zenodo.10970770.

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In the evolving landscape of clinical diagnostics, the significance of folate takes center stage as precision and innovation shape advancements in analytical methodologies. Folate, a pivotal element in cellular metabolism, governs physiological processes and serves as an indicator for various medical conditions. This study employs the Chemiluminescent Microparticle Immunoassay (CMIA), known for its accuracy, to assess the reproducibility and repeatability of serum folate levels. Folate's role in cellular metabolism influences diverse physiological functions, making its precise quantification crucial for identifying and monitoring conditions such as folate deficiency. The CMIA method emerges as a robust approach, leveraging immunological specificity for high precision and reliability. Utilizing the Abbott Alinity ci&reg; Analyzer, a technologically advanced clinical chemistry instrument, this study incorporates a systematic analytical method verification procedure. This involves quantification through a standardized protocol and a comparative analysis against criteria set by esteemed societies (RICOS and FSCB), ensuring comprehensive insights into analysis techniques. The reproducibility test, evaluating the impact of various factors on assay results, reveals low Coefficient of Variation (CV) values (CV1: 10.25%, CV2: 8.58%, CV3: 9.13%) across different levels. The results align with quality control limits, emphasizing the method's reliability. Repeatability assessment demonstrates exceptionally low CV values (CV1: 4.84%, CV2: 3.41%, CV3: 1.89%), highlighting the method's stability and precision under controlled conditions.
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Imad-Eddine, El khamlichi, Mokhtari Issam, Douzi Nisma, et al. "Verification of analytical performance of Unsaturated iron binding capacity (UIBC) assay on the Abbott Alinity ci®: Experience of the central laboratory of Mohammed VI University Hospital of Oujda." World Journal of Biology Pharmacy and Health Sciences 18, no. 1 (2024): 147–53. https://doi.org/10.5281/zenodo.13711981.

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The verification of analytical methods is a requirement outlined by the International Organization for Standardization (ISO). This process involves evaluating the performance of an analytical method according to a well-defined protocol and subsequently comparing it with pre-established analytical objectives. In our study, we conducted an evaluation of the analytical performance of the unsaturated iron binding capacity assay using the Abbott kit on the Alinity CI analyzer in the biochemistry laboratory of Mohammed VI University Hospital in Oujda. The methodology employed adheres to the recommendations of the French accreditation committee (COFRAC) accreditation technical guide SH GTA 04, focusing on the assessment of reproducibility and repeatability. Overall, the results obtained from the study are considered satisfactory and align with the acceptability criteria recommended by the supplier. It's important to note that the accuracy and reliability of examination results are influenced not only by laboratory personnel, equipment, and environmental conditions, but also by the methods utilized and their eventual validation or verification.
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14

Zaïnab Kajeiou, Issam Mokhtari, Loubna Yacoubi, et al. "Verification of the analytical performance of the serum Folate assay on the Abbott Alinity ci®." GSC Biological and Pharmaceutical Sciences 26, no. 2 (2024): 199–205. http://dx.doi.org/10.30574/gscbps.2024.26.2.0068.

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In the evolving landscape of clinical diagnostics, the significance of folate takes center stage as precision and innovation shape advancements in analytical methodologies. Folate, a pivotal element in cellular metabolism, governs physiological processes and serves as an indicator for various medical conditions. This study employs the Chemiluminescent Microparticle Immunoassay (CMIA), known for its accuracy, to assess the reproducibility and repeatability of serum folate levels. Folate's role in cellular metabolism influences diverse physiological functions, making its precise quantification crucial for identifying and monitoring conditions such as folate deficiency. The CMIA method emerges as a robust approach, leveraging immunological specificity for high precision and reliability. Utilizing the Abbott Alinity ci® Analyzer, a technologically advanced clinical chemistry instrument, this study incorporates a systematic analytical method verification procedure. This involves quantification through a standardized protocol and a comparative analysis against criteria set by esteemed societies (RICOS and FSCB), ensuring comprehensive insights into analysis techniques. The reproducibility test, evaluating the impact of various factors on assay results, reveals low Coefficient of Variation (CV) values (CV1: 10.25%, CV2: 8.58%, CV3: 9.13%) across different levels. The results align with quality control limits, emphasizing the method's reliability. Repeatability assessment demonstrates exceptionally low CV values (CV1: 4.84%, CV2: 3.41%, CV3: 1.89%), highlighting the method's stability and precision under controlled conditions.
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15

Fatima-Zahra Joudar, Dounia El Moujtahide, El Houcine Sebbar, and Mohammed Choukri. "Verification of analytical performance of Complement C4 on the Abbott Alinity ci®: Experience of the central laboratory of Mohammed VI University Hospital of Oujda." World Journal of Biology Pharmacy and Health Sciences 20, no. 3 (2024): 623–29. https://doi.org/10.30574/wjbphs.2024.20.3.1025.

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The primary objective of our study was to validate the analytical performance of complement C4 assay performed on the Abbott Alinity ci®: analyzer using the Immunoturbidimetric method. This validation was conducted in the biochemistry laboratory at Mohammed VI University Hospital in Oujda. The methodology followed the guidelines outlined in the french accreditation committee (COFRAC) technical guide (GTA) 04, focusing on the evaluation of reproducibility and repeatability. Overall, the results were satisfactory and met the standards set by both the manufacturer and the French Society of Clinical Biology. This study highlights the capability of the biochemistry laboratory at Mohammed VI University Hospital in Oujda to deliver accurate and reliable results, which are critical for effective clinical diagnosis and decision-making.
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16

Imad-Eddine, El khamlichi, Mokhtari Issam, Douzi Nisma, et al. "Verification of analytical performance of alpha-fetoprotein assay on the Abbott Alinity ci®: Experience of the central laboratory of Mohammed VI University Hospital of Oujda." GSC Biological and Pharmaceutical Sciences 26, no. 1 (2024): 291–97. https://doi.org/10.5281/zenodo.10969657.

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The aim of our study was the verification of the analytical performance of alpha-fetoprotein determination on the Abbott CI analyzer utilizing the immuno-chemiluminescence method. The verification process was conducted in the biochemistry laboratory of Mohammed VI University Hospital of Oujda. The working methodology adapted is based on the recommendations of the protocol of the French accreditation committee (COFRAC) accreditation technical guide (GTA) 04, by the evaluation of reproducibility and repeatability. The results obtained by this evaluation were overall satisfactory and have meet the recommended criteria set by supplier and the French society of clinical biology. This study shows that the biochemistry laboratory of Mohammed VI University Hospital of Oujda can deliver an accurate and precise results which can be used for clinical diagnosis and decision making.
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17

KIDOUN, Asmae, Kholoud KRIMI, Imane DOUICHI, et al. "Verification of analytical performance of Carcinoembryonic antigen assay on the Abbott Alinity ci®: Experience of the central laboratory of Mohammed VI University Hospital of Oujda." World Journal of Biology Pharmacy and Health Sciences 19, no. 2 (2024): 191–96. https://doi.org/10.5281/zenodo.15004153.

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The aim of our study was the verification of the analytical performance of Carcinoembryonic antigen determination on the Abbott CI analyzer utilizing the immuno-chemiluminescence method. The verification process was conducted in the biochemistry laboratory of Mohammed VI University Hospital of Oujda. The working methodology adapted is based on the recommendations of the protocol of the French accreditation committee (COFRAC) accreditation technical guide (GTA) 04, by the evaluation of reproducibility and repeatability. The results obtained by this evaluation were overall satisfactory and have meet the recommended criteria set by supplier and the French society of clinical biology. This study shows that the biochemistry laboratory of Mohammed VI University Hospital of Oujda can deliver an accurate and precise results which can be used for clinical diagnosis and decision making.
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18

Imad-Eddine El khamlichi, Issam Mokhtari, Nisma Douzi, et al. "Verification of analytical performance of Unsaturated iron binding capacity (UIBC) assay on the Abbott Alinity ci®: Experience of the central laboratory of Mohammed VI University Hospital of Oujda." World Journal of Biology Pharmacy and Health Sciences 18, no. 2 (2024): 147–53. http://dx.doi.org/10.30574/wjbphs.2024.18.1.0169.

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The verification of analytical methods is a requirement outlined by the International Organization for Standardization (ISO). This process involves evaluating the performance of an analytical method according to a well-defined protocol and subsequently comparing it with pre-established analytical objectives. In our study, we conducted an evaluation of the analytical performance of the unsaturated iron binding capacity assay using the Abbott kit on the Alinity CI analyzer in the biochemistry laboratory of Mohammed VI University Hospital in Oujda. The methodology employed adheres to the recommendations of the French accreditation committee (COFRAC) accreditation technical guide SH GTA 04, focusing on the assessment of reproducibility and repeatability. Overall, the results obtained from the study are considered satisfactory and align with the acceptability criteria recommended by the supplier. It's important to note that the accuracy and reliability of examination results are influenced not only by laboratory personnel, equipment, and environmental conditions, but also by the methods utilized and their eventual validation or verification.
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19

Ismail Faiz, Asmae Rhoubi, Dounia El Moujtahide, El Houcine Sebbar, and Mohammed Choukri. "Verification of the analytical performance of BNP (Brain Natriuretic Peptide) Assay on the Abbott Alinity ci®: Experience of the Biochemistry laboratory of Mohammed VI University Hospital in Oujda/Morocco." GSC Biological and Pharmaceutical Sciences 30, no. 3 (2025): 071–76. https://doi.org/10.30574/gscbps.2025.30.3.0094.

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Brain Natriuretic Peptide (BNP) is a good cardiac biomarker used for diagnostic, prognostic, and therapeutic monitoring in heart failure, but also in other affections like pulmonary arterial hypertension (PAH). The purpose of our work is to evaluate the analytical performance of the BNP assay on the Abbott Alinity ci® Analyzer at the Biochemistry laboratory of the Mohammed VI University Hospital in Oujda. The methodology of this work is based on the evaluation of reproducibility and repeatability, based on the technical accreditation guide (SH GTA 04) of the French Accreditation Committee (COFRAC). The results obtained for the different BNP dosage verification criteria show satisfactory repeatability for all levels (1: low / 2: medium, and 3: high), Intra-laboratory reproducibility was also satisfactory for all levels. By comparing these results with the CV used by the CLSI, we see that the results are consistent with and below the tolerated limits. This study shows that the Biochemistry laboratory of the Mohammed VI University Hospital in Oujda can provide accurate and precise results which regards with the requirements of learned societies for the determination of BNP.
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Fatima-Zahra Joudar, Dounia El Moujtahide, El Houcine Sebbar, and Mohammed Choukri. "Verification of analytical performance of Complement C3 on the Abbott Alinity ci®: Experience of the central laboratory of Mohammed VI University Hospital of Oujda." World Journal of Biology Pharmacy and Health Sciences 21, no. 2 (2025): 103–10. https://doi.org/10.30574/wjbphs.2025.21.2.1079.

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The verification of analytical methods is a requirement outlined by the International Organization for Standardization (ISO). This process involves evaluating the performance of an analytical method according to a well-defined protocol and subsequently comparing it with pre-established analytical objectives. In our study, we conducted an evaluation of the analytical performance of Complement C3 using the Abbott kit on the Alinity CI analyzer in the biochemistry laboratory of Mohammed VI University Hospital in Oujda. The methodology employed adheres to the recommendations of the French accreditation committee (COFRAC) accreditation technical guide SH GTA 04, focusing on the assessment of reproducibility and repeatability.The results obtained demonstrate good repeatability, with CV1 = 1.04%, CV2 = 1.13%, and CV3 = 0.97% for levels 1, 2, and 3, respectively. Intra-laboratory reproducibility was also satisfactory for levels 1, 2, and 3, with CV1 = 4.8%, CV2 = 3.13%, and CV3 = 2.9%. Confirming the performance of this method is essential, given the qualitative and quantitative importance of Complement C3 measurement in our daily practice. It's important to note that the accuracy and reliability of examination results are influenced not only by laboratory personnel, equipment, and environmental conditions, but also by the methods utilized and their eventual validation or verification.
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21

KIDOUN Asmae, KRIMI Kholoud, DOUICHI Imane, et al. "Verification of analytical performance of Carcinoembryonic antigen assay on the Abbott Alinity ci®: Experience of the central laboratory of Mohammed VI University Hospital of Oujda." World Journal of Biology Pharmacy and Health Sciences 19, no. 2 (2024): 191–69. http://dx.doi.org/10.30574/wjbphs.2024.19.2.0512.

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The aim of our study was the verification of the analytical performance of Carcinoembryonic antigen determination on the Abbott CI analyzer utilizing the immuno-chemiluminescence method. The verification process was conducted in the biochemistry laboratory of Mohammed VI University Hospital of Oujda. The working methodology adapted is based on the recommendations of the protocol of the French accreditation committee (COFRAC) accreditation technical guide (GTA) 04, by the evaluation of reproducibility and repeatability. The results obtained by this evaluation were overall satisfactory and have meet the recommended criteria set by supplier and the French society of clinical biology. This study shows that the biochemistry laboratory of Mohammed VI University Hospital of Oujda can deliver an accurate and precise results which can be used for clinical diagnosis and decision making.
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Imad-Eddine El khamlichi, Issam Mokhtari, Nisma Douzi, et al. "Verification of analytical performance of alpha-fetoprotein assay on the Abbott Alinity ci®: Experience of the central laboratory of Mohammed VI University Hospital of Oujda." GSC Biological and Pharmaceutical Sciences 26, no. 1 (2024): 291–197. http://dx.doi.org/10.30574/gscbps.2024.26.1.0035.

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The aim of our study was the verification of the analytical performance of alpha-fetoprotein determination on the Abbott CI analyzer utilizing the immuno-chemiluminescence method. The verification process was conducted in the biochemistry laboratory of Mohammed VI University Hospital of Oujda. The working methodology adapted is based on the recommendations of the protocol of the French accreditation committee (COFRAC) accreditation technical guide (GTA) 04, by the evaluation of reproducibility and repeatability. The results obtained by this evaluation were overall satisfactory and have meet the recommended criteria set by supplier and the French society of clinical biology. This study shows that the biochemistry laboratory of Mohammed VI University Hospital of Oujda can deliver an accurate and precise results which can be used for clinical diagnosis and decision making.
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Mohamed Karim EL AZZOUZI, Sara MOULAY RCHID, Khalil BOURCHID, Dounia ELMOUJTAHIDE, El-Houcine SEBBAR, and Mohammed CHOUKRI. "Verification of analytical performance of intact parathyroid hormone assay on the Abbott Alinity ci®: Experience of the central laboratory of Mohammed VI University Hospital of Oujda." World Journal of Biology Pharmacy and Health Sciences 19, no. 3 (2024): 582–88. http://dx.doi.org/10.30574/wjbphs.2024.19.3.0691.

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The primary goal of our study was to verify the analytical performance of intact parathyroid hormone measurements conducted on the Abbott CI analyzer using the immuno-chemiluminescence method. This verification took place in the biochemistry laboratory at Mohammed VI University Hospital in Oujda. Our methodology was aligned with the recommendations outlined in the French accreditation committee (COFRAC) technical guide (GTA) 04, emphasizing the assessment of reproducibility and repeatability. Overall, the results of this evaluation were satisfactory and met the standards set by both the supplier and the French Society of Clinical Biology. This study illustrates that the biochemistry laboratory at Mohammed VI University Hospital of Oujda is equipped to provide accurate and precise results, which are crucial for effective clinical diagnosis and decision-making.
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Mohamed Karim EL AZZOUZI, Sara MOULAY RCHID, Khalil BOURCHID, Dounia ELMOUJTAHIDE, El-Houcine SEBBAR, and Mohammed CHOUKRI. "Verification of analytical performance of the 25-OH vitamin D assay on the Abbott Alinity ci®: Experience of the central laboratory of Mohammed VI University Hospital of Oujda." World Journal of Biology Pharmacy and Health Sciences 20, no. 1 (2024): 476–82. http://dx.doi.org/10.30574/wjbphs.2024.20.1.0727.

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The primary goal of our study was to verify the analytical performance of the 25-OH Vitamin D measurements conducted on the Abbott CI analyzer using the immuno-chemiluminescence method. This verification took place in the biochemistry laboratory at Mohammed VI University Hospital in Oujda. Our methodology was aligned with the recommendations outlined in the French accreditation committee (COFRAC) technical guide (GTA) 04, emphasizing the assessment of reproducibility and repeatability. Overall, the results of this evaluation were satisfactory and met the standards set by both the supplier and the French Society of Clinical Biology. This study illustrates that the biochemistry laboratory at Mohammed VI University Hospital of Oujda is equipped to provide accurate and precise results, which are crucial for effective clinical diagnosis and decision-making.
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Amina, Himri, Grari Oussama, Kajeiou Zainab, et al. "Verification of analytical performance of the C- peptide assay on the Abbott Alinity ci®: Experience of the central laboratory of Mohammed VI University Hospital of Oujda." GSC Biological and Pharmaceutical Sciences 28, no. 2 (2024): 153–61. https://doi.org/10.5281/zenodo.14676511.

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The objective of our study was to assess the analytical performance of C- peptide determination using a two-step immunoassay with microparticle chemiluminescence immunoassay (CMIA) technology, adhering to Scope A criteria outlined in the guide for the verification/validation of medical biology methods. We analyzed the C- peptide assay's intermediate precision and reproducibility. For the three levels (low, medium, and high), the obtained results are very satisfactory. For intermediate fidelity, the coefficients of variation are 2.52%, CV2 = 3.70%, and CV3 = 4.37%, respectively. For repeatability, the results): CV1 = 3.15%, CV2 = 1.65%, and CV3 = 1.55%, respectively. The obtained results enabled verification of method performance and comparison with predefined analytical objectives to ensure compliance with regulatory and normative standards. The central laboratory at University Hospital Mohammed VI of Oujda adheres to a quality policy focused on mastering various analytical systems.
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Amina Himri, Oussama Grari, Zainab Kajeiou, et al. "Verification of analytical performance of the C- peptide assay on the Abbott Alinity ci®: Experience of the central laboratory of Mohammed VI University Hospital of Oujda." GSC Biological and Pharmaceutical Sciences 28, no. 2 (2024): 153–61. http://dx.doi.org/10.30574/gscbps.2024.28.2.0300.

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The objective of our study was to assess the analytical performance of C- peptide determination using a two-step immunoassay with microparticle chemiluminescence immunoassay (CMIA) technology, adhering to Scope A criteria outlined in the guide for the verification/validation of medical biology methods. We analyzed the C- peptide assay's intermediate precision and reproducibility. For the three levels (low, medium, and high), the obtained results are very satisfactory. For intermediate fidelity, the coefficients of variation are 2.52%, CV2 = 3.70%, and CV3 = 4.37%, respectively. For repeatability, the results): CV1 = 3.15%, CV2 = 1.65%, and CV3 = 1.55%, respectively. The obtained results enabled verification of method performance and comparison with predefined analytical objectives to ensure compliance with regulatory and normative standards. The central laboratory at University Hospital Mohammed VI of Oujda adheres to a quality policy focused on mastering various analytical systems.
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Laryea, Erving T., Kelsey Mitchell, Eric Standford, Julia Hernandez, and Joesph R. Wiencek. "Analytical Performance Evaluation of BioRad’s Unassayed Multiqual, Immunoassay Plus and Assayed Multiqual InteliQ Tube-Based Quality Control Materials." American Journal of Clinical Pathology 160, Supplement_1 (2023): S130. http://dx.doi.org/10.1093/ajcp/aqad150.282.

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Abstract Introduction Quality control (QC) practices commonly require aliquoting of liquid material into sample cups prior to analysis. Recently, newer tube-based QC has become available that can be scanned directly onto the analyzer without additional aliquoting. In this study, we evaluate the performance of the BioRad’s Unassayed Multiqual (Mutiqual), Immunoassay (IA) Plus and Assayed InteliQ Muliqual (InteliQ) tube-based QC material. Materials and Methods The analytical performance of Multiqual, IA Plus and InteliQ materials were compared over 14 days at three concentrations on an Abbott Alinity ci analyzer system. The analysis included 20 unique clinical chemistry and 4 immunoassay analytes. For an applied comparison, all QC materials were analyzed using the same lot on multiple days, times, and by various laboratory team members (n=10). The means, standard deviations (SD) and coefficient of variation (CV) were calculated for each analyte. Minimum acceptable allowable imprecision (I) specifications were set using the biological variation (BV) database from European Federation for Laboratory Medicine (EFLM), which was calculated for each analyte using the equation I = 0.75*CV within-subject. Sample cups used for Multiqual and IA plus were also calculated to determine consumable waste for these materials over the study period and extrapolated for a year. Results Multiqual, IA Plus and InteliQ CVs for each analyte were compared to the EFLM BV database and showed comparable results for most analytes studied. Most analytes demonstrated &amp;lt; 5% CV over the 14-day period for InteliQ except alkaline phosphatase, bicarbonate, total bilirubin, and triiodothyronine for either 1, 2 or 3 levels. Total bilirubin and free thyroxine were outside this CV for Multiqual and IA Plus. In addition, minimum acceptable allowable imprecision goals from EFLM were not met for several analytes that were included in InteliQ such as albumin, alkaline phosphatase, aspartate aminotransferase, calcium, bicarbonate, chloride, and sodium. Multiqual and IA plus analytes that did not meet imprecision goals were bicarbonate, chloride, sodium, and free thyroxine, respectively. A total of 84 sample cups were needed to perform Multiqual and IA plus QC analysis over the study period or approximately 2184 over a year. Conclusion Multiqual, IA Plus and InteliQ QC materials provide similar analytical performance although each material had some analytes that did not meet acceptable imprecision limits defined by EFLM. Implementation of new tube-based QC materials can reduce sample cup consumables and may reduce technologist time required to aliquot Multiqual and IA Plus.
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Hashim, Ibrahim A., Khanh Q. Nguyen, Rachel H. Langevin, and Michael John McPhaul. "Macroprolactin Molecular Heterogeneity and Variable Immunoassay Reactivity." Journal of the Endocrine Society 5, Supplement_1 (2021): A542—A543. http://dx.doi.org/10.1210/jendso/bvab048.1105.

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Abstract Circulating prolactin (PRL) exhibits molecular heterogeneity the clinical significance of which is not known. Macroprolactin (mPRL) is widely reported, however, its heterogeneity is unknown. In addition to determining its molecular nature, the relative impact of the various forms on routinely available immunoassays needs to be examined. This study, applied various proteomics techniques to define the nature of mPRL and examined the effect of those forms on its measurement. Methods: Samples suspected of false hyperprolactinemia were subjected to; 1) precipitation by polyethylene glycol, 2) gel permeation chromatography, 3) protein-G affinity chromatography to identify presence of PRL-antibody complex and, 4) samples negative for antibody by step (3) were applied onto a lectin concanavalin A column to examine the presence of glycosylated PRL forms. Analysis was according to manufacturer’s instructions. All study samples and their chromatography fractions were measured using highly sensitive ELISA (DuoSet, R&amp;D Systems, MN). Samples identified above as containing different mPRL forms were analyzed using four immunoassay analyzers in routine clinical use, namely; Advia Centaur® and Atellica® (Siemens, PA), Alinity-ci (Abbott Laboratories, IL), and Cobas 6000® (Roche Diagnostics, IN). Results: A total of 13 samples were entered into the study. PRL levels ranged from 21.4 to 1,469 ng/mL (median 48.8). Samples positive for mPRL (n=8) (with &amp;lt;40% recovery by PEG) exhibited predominant (52.3 to 95.0%) PRL activity in the (H) range (≥150kDa), with significant but relatively lower amount (3.6 to 34.1%) in the (M) range (≥30&amp;lt;150kDa) and (1.4 to 34.5%) at the (L) range (&amp;lt;30kDa). Samples negative for mPRL exhibited little PRL activity (1.2 to 5.1%) in (H) range, predominantly (60.0 to 79.4%) in the (M) range and moderate presence (15.4 to 38.9 %) in the (L) range. Two samples indeterminate for mPRL contained prolactin forms at all molecular weight levels, (H) (7.9, 27.1%), (M) (67.0, 40.7%), and (L) (5.9, 51.4%). Samples with mPRL exhibited significant binding to protein G affinity column indicating presence of PRL-antibody complex. Samples with (M) range mPRL forms exhibited significant lectin affinity binding. Samples with (H) mPRL showed markedly high PRL by two of the analyzers (Atellica®, Abbott Laboratories) and Cobas 6000®, (Roche Diagnostics). The deviation was more marked when using the Atellica® compared to Cobas 6000®. Samples with (M) mPRL showed marked deviation using the Roche Cobas 6000® compared to the others. In conclusion: Macroprolactin is heterogenous with antibody-PRL complex and aggregated glycosylated forms. Those forms exhibit variable immunoassay reactivity in different routinely used assays. Knowledge of circulating form as well as of their immunoreactivity is important when suspecting false hyperprolactinemia due to macroprolactin.
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Derbie, Awoke, Bereket Amare, Eyaya Misgan, et al. "Histopathological profile of cervical punch biopsies and risk factors associated with high-grade cervical precancerous lesions and cancer in northwest Ethiopia." PLOS ONE 17, no. 9 (2022): e0274466. http://dx.doi.org/10.1371/journal.pone.0274466.

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Introduction Cervical cancer is an important public health problem in Ethiopia. However, the disease is not well characterized and studied in various parts of the country. This study was designed to describe the histopathological profile of cervical biopsies and to identify risk factors associated with high-grade cervical lesions and cancer (CIN2+C). Methods A cross-sectional study was conducted at Felege Hiwot Compressive Specialized Hospital (FHCSH) between 1 March 2019 and 30 October 2021. A structured questionnaire was used to collect data on the participants’ demographic, reproductive and gynecologic history. From women presented with different degrees of cervical lesions, a senior gynecologist collected cervical swabs using (Digene HC2 DNA collection device: Qiagen, Hilden, Germany) for detection of high-risk Human papillomaviruses (HR-HPV) and punch biopsy for histopathological examinations. HR-HPVs were detected using the Abbott Alinity m system following the manufacturer protocol at the Institute of Virology, Leipzig University Hospital, Germany. Collected data entered and analyzed using SPSS version 25. A logistic regression model was used for both bivariable &amp; multivariable analysis in order to determine the association between independent variables and CIN2+C. Statistical significance was set at a p-value &lt;0.05. Results In this study, 335 women were included; the mean age was at 46.5±11.4 years. Most were living in rural settings, 221(66%) and had no formal education, 259 (77.3%). More than half of the participants, 193(57.6%) were unaware of cervical cancer. The prevalence of HIV infection and previous history of cervical screening were 44(13.1%) and 93(27.8%), respectively. HR-HPVs were detected in 178(54.3%) of the participants. The majority of biopsies, 140(41.8%; 95%CI: 36.6–47.1%), were diagnosed as cervical carcinoma. Normal histology, cervicitis, cervical intraepithelial neoplasia (CIN)-1, CIN-2, and CIN-3 accounted for 74(22.1%), 30(9.0%), 40(11.9%), 12(3.6%), and 12(3.6%), respectively. High-grade lesions and cancer (CIN2+C) together accounted 164(49.0%; 95%CI: 43.6–54.2). Cervical cancer increased steadily with the age of the participants (p&lt;0.001) in which women above the age of fifty were approximately four times more likely to develop CIN2+C than the younger ones (AOR: 3.73; 95%CI: 1.80–7.82; p&lt;0.001). Likewise, no screening history in the last five years (AOR: 2.03; 95%CI: 1.05–3.92; p = 0.035) and being infected with HR-HPVs (AOR: 14.23; 95%CI: 7.9–25.64; p&lt;0.001) were found significantly associated with CIN2+C. Conclusions The findings of this study revealed that cervical cancer continues to be an important women’s health challenge in northwest Ethiopia. Postmenopausal women, who had no screening history within a five-year period and those women who tested positive for HR-HPV need special attention. It is important to increase the awareness of women about cervical cancer and actions for early detection of precancerous lesions should be expanded.
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Sharrod-Cole, Hayley, and Clare Ford. "Multicenter Evaluation of a High-Sensitivity Troponin I Assay and Verification of an Early Rule-Out Algorithm." Journal of Applied Laboratory Medicine 4, no. 1 (2019): 95–100. http://dx.doi.org/10.1373/jalm.2018.027466.

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Abstract Background The objectives of this study were to independently evaluate the analytical performance of the STAT high-sensitivity troponin I (hs-cTnI) assay on a recently launched and CE-marked integrated chemistry and immunoassay system, confirm acceptable performance of the assay in line with The Third Global MI Task Force recommendations, and confirm suitability of the assay for continued use of an early rule-out algorithm for acute coronary syndrome at our Trust. Methods A multicenter evaluation of the analytical performance characteristics of the hs-cTnI assay on the Abbott Alinity ci series was performed in 5 clinical laboratories across Europe. Comparison studies were performed vs the existing Abbott ARCHITECT hs-cTnI assay. Results Passing and Bablok regression analysis revealed a slope of 0.99 [95% confidence interval (CI), 0.98–1.00] and an intercept of −0.09 ng/L (95% CI, −0.21–0.11). Intermediate imprecision ranged from 3.7% to 5.4%, 2.6% to 4.5%, and 2.0% to 6.1% at concentrations of 19.1–21.1 ng/L, 196.6–205.5 ng/L, and 15229–16265 ng/L, respectively. There was good concordance between the 2 assays at the early rule-out cutoff. Conclusion Comparable analytical performance of the hs-cTnI assay on new Abbott Alinity ci series supports the continued use of the early rule out algorithm for patients with suspected ACS at our Trust.
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Loubna Yacoubi, Zainab Kajeiou, Sabah Mokhtari, et al. "Verification of the analytical performance of the serum gamma-glutamyl transferase assay on the Abbott Alinity ci®: Experience of the biochemistry laboratory of the Mohammed VI university hospital of Oujda." World Journal of Biology Pharmacy and Health Sciences 15, no. 2 (2023): 098–103. http://dx.doi.org/10.30574/wjbphs.2023.15.2.0349.

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Introduction: As part of our study, we set out to evaluate the analytical performance of the gamma-glutamyl transferase (GGT) assay using an Abbott kit on the Alinity ci® automated system in the biochemistry laboratory of the CHU Mohammed VI in Oujda. Materials and methods: This study assessed the repeatability and reproducibility of Alinity ci® and compared the results obtained by the Alinity ci® and Architect ci-8200® automated systems. Results: The results obtained met the acceptability criteria recommended by the supplier and the Valtec protocol of the Société Française de Biologie Clinique (SFBC), demonstrating overall satisfaction with the study. The Alinity ci® automated system demonstrated the analytical performance required for accurate and reliable determination of GGT levels. Discussion: Validation of an analytical method is an essential step in guaranteeing that the result obtained is as close as possible to the reference value of a sample. Several standards and technical guides set out requirements for the performance criteria of an analytical method, notably NF EN ISO 15 189. Conclusion: the verification study of the GGT assay method produced satisfactory results, providing a high level of reliability for analysis results from the central laboratory of the CHU Mohammed VI d'Ouja. This work forms an essential basis for developing an accreditation procedure, which is part of the quality approach to which our laboratory is committed.
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Loubna Yacoubi, Mouad Harandou, Amina Himri, et al. "Verification of the analytical performance of the serum haptoglobin assay on the Abbott Alinity ci." GSC Biological and Pharmaceutical Sciences 26, no. 1 (2024): 242–46. http://dx.doi.org/10.30574/gscbps.2024.26.1.0024.

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Introduction: The aim of our study is to evaluate the haptoglobin assay on the Alinity ci automated system. This evaluation is part of an overall approach to verifying the methods used in the central laboratory of the Mohammed VI University Hospital of Oujda , with a view to compiling an accreditation file in accordance with the requirements of standard NF ISO 15189. Materials and methods: The working methodology adapted by our study is based on the recommendations of the protocol of the COFRAC accreditation technical guide SH GTA 04. Verification involved assessing the repeatability and reproducibility of Alinity ci . Results: The results obtained for the various haptoglobin assay verification criteria show satisfactory repeatability for all three levels, with CV1=1.10%, CV2=0.78% and CV3=1.07% respectively. intra-laboratory reproducibility was satisfactory for all three levels, with CV1=1.79%, CV2= 4.2% and CV3=1.62% respectively. Discussion: Verification of an analytical method is an essential step in guaranteeing that the result obtained is as close as possible to the reference value of a sample. Comparing our results with the CV adopted by the SFBC, we can see that the results are in line with and below the tolerated limits. Conclusion: We can therefore conclude that the Abbott Alinity ci system meets the requirements set by scientific societies for the determination of haptoglobin.
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Loubna, Yacoubi, Harandou Mouad, Himri Amina, et al. "Verification of the analytical performance of the serum haptoglobin assay on the Abbott Alinity ci." GSC Biological and Pharmaceutical Sciences 26, no. 1 (2024): 242–46. https://doi.org/10.5281/zenodo.10969394.

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Introduction: The aim of our study is to evaluate the haptoglobin assay on the Alinity ci automated system. This evaluation is part of an overall approach to verifying the methods used in the central laboratory of the Mohammed VI University Hospital of Oujda , with a view to compiling an accreditation file in accordance with the requirements of standard NF ISO 15189. Materials and methods: The working methodology adapted by our study is based on the recommendations of the protocol of the COFRAC accreditation technical guide SH GTA 04. Verification involved assessing the repeatability and reproducibility of Alinity ci . Results: The results obtained for the various haptoglobin assay verification criteria show satisfactory repeatability for all three levels, with CV1=1.10%, CV2=0.78% and CV3=1.07% respectively. intra-laboratory reproducibility was satisfactory for all three levels, with CV1=1.79%, CV2= 4.2% and CV3=1.62% respectively. Discussion: Verification of an analytical method is an essential step in guaranteeing that the result obtained is as close as possible to the reference value of a sample. Comparing our results with the CV adopted by the SFBC, we can see that the results are in line with and below the tolerated limits. Conclusion: We can therefore conclude that the Abbott Alinity ci system meets the requirements set by scientific societies for the determination of haptoglobin.
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Loubna, Yacoubi, Kajeiou Zainab, Mokhtari Sabah, et al. "Verification of the analytical performance of the serum gamma-glutamyl transferase assay on the Abbott Alinity ci®: Experience of the biochemistry laboratory of the Mohammed VI university hospital of Oujda." World Journal of Biology Pharmacy and Health Sciences 15, no. 2 (2023): 098–103. https://doi.org/10.5281/zenodo.10677048.

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<strong>Introduction</strong>: As part of our study, we set out to evaluate the analytical performance of the gamma-glutamyl transferase (GGT) assay using an Abbott kit on the Alinity ci&reg; automated system in the biochemistry laboratory of the CHU Mohammed VI in Oujda. <strong>Materials and methods</strong>: This study assessed the repeatability and reproducibility of Alinity ci&reg; and compared the results obtained by the Alinity ci&reg; and Architect ci-8200&reg; automated systems. <strong>Results</strong>: The results obtained met the acceptability criteria recommended by the supplier and the Valtec protocol of the Soci&eacute;t&eacute; Fran&ccedil;aise de Biologie Clinique (SFBC), demonstrating overall satisfaction with the study. The Alinity ci&reg; automated system demonstrated the analytical performance required for accurate and reliable determination of GGT levels. <strong>Discussion</strong>: Validation of an analytical method is an essential step in guaranteeing that the result obtained is as close as possible to the reference value of a sample. Several standards and technical guides set out requirements for the performance criteria of an analytical method, notably NF EN ISO 15 189. <strong>Conclusion</strong>: the verification study of the GGT assay method produced satisfactory results, providing a high level of reliability for analysis results from the central laboratory of the CHU Mohammed VI d'Ouja. This work forms an essential basis for developing an accreditation procedure, which is part of the quality approach to which our laboratory is committed.
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Sabah Mokhtari, Amina Himri, Loubna Yacoubi, et al. "Verification of the analytical performance of CA 19-9 assay on Abbott Alinity ci®: Experience of the central laboratory Mohammed VI Oujda." World Journal of Biology Pharmacy and Health Sciences 17, no. 1 (2024): 129–35. http://dx.doi.org/10.30574/wjbphs.2024.17.1.0031.

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Introduction: CA19-9 is a marker used in the diagnosis and monitoring of several cancer diseases. The aim of this study is to evaluate the CA19-9 assay on the Abbott ALinity Ci automated system. This evaluation is part of an overall approach to verifying the methods used in the CHU's central laboratory, with a view to compiling an accreditation file in line with the requirements of standard NF EN ISO 15189. Materials and methods: The aim of our study was to evaluate the scope A criteria detailed in the guide to verification/validation of methods in Medical Biology, in accordance with the recommendations of standards NF EN ISO/CEI 17025, NF EN ISO 15189 and NF EN ISO 22870. Verification was carried out on the CA19-9 assay on Alinity® Ci, which uses the immunoassay technique Criteria (repeatability, reproducibility) were verified. Results: The results obtained show good repeatability for the 3 levels with respectively CV1=2,61% , CV2=2,78% , and CV3 =3,26% % and intra-laboratory reproducibility with CV1=3,98% , CV2= 3,16% and CV3 = 3,61%. Discussion and Conclusion: The central laboratory of our University Hospital is committed to a quality policy which includes a control approach for the various analytical systems used. The results obtained for the various CA19-9 assay verification criteria on our Alinity® Ci system, compared with data from the supplier, RICOS and learned societies, are satisfactory and verify analytical performance.
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Sabah, Mokhtari, Himri Amina, Yacoubi Loubna, et al. "Verification of the analytical performance of CA 19-9 assay on Abbott Alinity ci®: Experience of the central laboratory Mohammed VI Oujda." World Journal of Biology Pharmacy and Health Sciences 17, no. 1 (2024): 129–35. https://doi.org/10.5281/zenodo.11245041.

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<strong>Introduction</strong>: CA19-9 is a marker used in the diagnosis and monitoring of several cancer diseases. The aim of this study is to evaluate the CA19-9 assay on the Abbott ALinity Ci automated system. This evaluation is part of an overall approach to verifying the methods used in the CHU's central laboratory, with a view to compiling an accreditation file in line with the requirements of standard NF EN ISO 15189. <strong>Materials and methods</strong>: The aim of our study was to evaluate the scope A criteria detailed in the guide to verification/validation of methods in Medical Biology, in accordance with the recommendations of standards NF EN ISO/CEI 17025, NF EN ISO 15189 and NF EN ISO 22870. Verification was carried out on the CA19-9 assay on Alinity&reg; Ci, which uses the immunoassay technique Criteria (repeatability, reproducibility) were verified. <strong>Results</strong>:&nbsp; The results obtained show good repeatability for the 3 levels with respectively CV1=2,61% , CV2=2,78% , and CV3 =3,26% % and intra-laboratory reproducibility with CV1=3,98% , CV2= 3,16% and CV3 = 3,61%. <strong>Discussion and Conclusion</strong>: The central laboratory of our University Hospital is committed to a quality policy which includes a control approach for the various analytical systems used. The results obtained for the various CA19-9 assay verification criteria on our Alinity&reg; Ci system, compared with data from the supplier, RICOS and learned societies, are satisfactory and verify analytical performance.
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Soufiane Beyyoudh, Issam Mokhtari, Oussama Grari, et al. "Verification of analytical performance of the aspartate aminotransferase assay on the Abbott Alinity ci®: Experience of the central laboratory Mohammed VI Oujda." World Journal of Biology Pharmacy and Health Sciences 15, no. 3 (2023): 037–42. http://dx.doi.org/10.30574/wjbphs.2023.15.3.0378.

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The standard NF EN ISO 15 189 mandates the verification of analytical methods. It involves evaluating an analytical method's effectiveness in accordance with a precisely laid out protocol before comparing it to previously established analytical objectives. Any biologist must be concerned with mastering this approach. In this work, we compare two automats: Alinity ci ® and Architect ci-8200® Abbott, to show the results of the protocol of verification of the method of determination of aspartate aminotransferase (AST). Aspartate aminotransferase is an enzyme found in many tissues, particularly liver and muscle, including heart muscle. Its measurement is particularly useful for diagnosing and monitoring liver disease.
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Sabah Mokhtari, Loubna Yacoubi, Imane Naji, et al. "Verification of the analytical performance of the serum phosphorus assay on the Abbott Alinity ci®: Experience of the central laboratory Mohammed VI University Hospital of Oujda." World Journal of Biology Pharmacy and Health Sciences 16, no. 1 (2023): 233–38. http://dx.doi.org/10.30574/wjbphs.2023.16.1.0401.

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Introduction: In our study, we aimed to evaluate the analytical performance of the serum phosphorus determination method using an Abbott kit on the Alinity c automaton at the biochemistry laboratory of Mohammed VI University Hospital of Oujda. Materials and methods: We evaluated the performance of the kit using flexible scope A and conducted a thorough performance study on the Alinity c automaton. This study encompassed assessments of repeatability, reproducibility and comparisons of results obtained from two Alinity c automatons. Results: The obtained results met the acceptability criteria recommended by the supplier and the French Society of Clinical Biology(Société Française de Biologie Clinique SFBC) Valtec protocol, indicating overall satisfaction with the study. The Alinity c automaton exhibited the necessary analytical performance to ensure accurate and dependable determination of phosphorus levels. Discussion: Ensuring accurate and reliable results, the verification of the serum phosphorus determination method in the medical laboratory is crucial. This process entails implementing quality control measures, calibration, and comparing with established reference methods. It guarantees that the laboratory's phosphorus testing method is precise, accurate, and compliant with industry standards, thereby upholding the quality of patient care. Conclusion: The verification study of the serum phosphorus determination method yielded satisfactory results, providing high reliability to the test results from the central laboratory at Mohammed VI University Hospital of Oujda. This verification study serves as a strong foundation in the accreditation process, ensuring the accuracy and quality of laboratory testing, and enhancing the overall reliability of patient care
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Kanani, Fatima Zehra, Adnan Haider Kazmi, and Bushra Kaleem. "La métrica Sigma del sistema Alinity ci: estudio sobre 39 magnitudes químicas y de inmunoensayo." Advances in Laboratory Medicine / Avances en Medicina de Laboratorio 2, no. 2 (2021): 277–85. http://dx.doi.org/10.1515/almed-2021-0025.

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Resumen Objetivos La métrica Sigma es una forma útil y económica de verificar la calidad de las pruebas en los laboratorios clínicos. Alinity ci es un analizador (Abbott Diagnostics) lanzado recientemente, cuyo rendimiento aún no ha sido suficientemente estudiado. Calculamos el valor Sigma de 39 magnitudes químicas y de inmunoensayo de dos sistemas Alinity ci. Métodos Las métricas Sigma se derivaron de los estudios de validación del método. El coeficiente de variación (CV) se estimó siguiendo la guía CLSP EP 15. Se emplearon tres métodos para comprobar desviaciones: material de evaluación de rendimiento, comparación de métodos alternativos y prueba de linealidad. Se emplearon límites de error total permitido similares o inferiores a los de los estudios de referencia. Resultados Todas las magnitudes químicas, excepto el nitrógeno ureico en sangre (BUN), mostraron un valor Sigma &gt; 6 en uno o más niveles y métodos. Ninguna de las magnitudes estudiadas obtuvo &lt;3 Sigma. Entre los electrolitos, el sodio obtuvo &lt;3 Sigma en dos niveles en el método de evaluación de rendimiento, aunque alcanzó &gt;4 Sigma en los otros dos métodos. Los niveles Sigma obtenidos fueron similares a los de estudios anteriores. Conclusiones Los valores de Sigma fueron aceptables en todas las magnitudes químicas, de inmunoensayo y electrolitos analizados con Alinity ci. La métrica Sigma es una herramienta objetiva, económica y extendida de control interno de la calidad. Calculamos la métrica Sigma de numerosas pruebas de alto rendimiento. Es necesario evaluar el rendimiento de estas pruebas a largo plazo.
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Houria MADANI, Amina HIMRI, Dounia EL MOUJTAHIDE, El Houcine SEBBAR, and Mohammed CHOUKRI. "Verification of the insulin dosage method using Abbott Alinity ci®: experience of the biochemistry laboratory, CHU Mohammed IV Oujda, Morocco." GSC Biological and Pharmaceutical Sciences 28, no. 1 (2024): 164–70. http://dx.doi.org/10.30574/gscbps.2024.28.1.0271.

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Introduction: The aim of our study was to evaluate the analytical performance of the insulin dosage method, which was performed by the Alinity ci® automated system in the biochemistry laboratory of the Mohammed VI University Hospital in Oujda. Insulin acts as an essential role in regulating the body's energy supply, mainly by balancing blood sugar levels via the storage of glucose in the liver, muscles and adipose tissue. Materials and methods: We carried out a study of the performance of the Alinity ci® automated system, assessing repeatability and reproducibility in accordance with the COFRAC GTA 04 accreditation technical guide, which meets the quality requirements of standard ISO 15 189. Results: The results of our study show satisfactory repeatability for the three levels (Low; Medium; High) with CV1 = 2.44 %, CV2 = 1.76 %, CV3 = 1.33 %. The reproducibility of insulin was also satisfactory, with respect to the coefficient of variation (CV) for the three levels (Low, Medium, High), respectively CV1 = 3.16 %, CV2 = 5.78 %, CV3 = 2.88 %. Conclusion: The reliability of our laboratory's insulin assay results is demonstrated by the satisfactory results obtained in our study, which comply with RICOS and FSCB recommendations.
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Sabah, Mokhtari, Yacoubi Loubna, Naji Imane, et al. "Verification of the analytical performance of the serum phosphorus assay on the Abbott Alinity ci®: Experience of the central laboratory Mohammed VI University Hospital of Oujda." World Journal of Biology Pharmacy and Health Sciences 16, no. 1 (2023): 233–38. https://doi.org/10.5281/zenodo.10791239.

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<strong>Introduction:</strong>&nbsp;In our study, we aimed to evaluate the analytical performance of the serum phosphorus determination method using an Abbott kit on the Alinity c automaton at the biochemistry laboratory of Mohammed VI University Hospital of Oujda. <strong>Materials and methods:&nbsp;</strong>We evaluated the performance of the kit using flexible scope A and conducted a thorough performance study on the Alinity c automaton. This study encompassed assessments of repeatability, reproducibility and comparisons of results obtained from two Alinity c automatons. <strong>Results:&nbsp;</strong>The obtained results met the acceptability criteria recommended by the supplier and the French Society of Clinical Biology(Soci&eacute;t&eacute; Fran&ccedil;aise de Biologie Clinique SFBC) Valtec protocol, indicating overall satisfaction with the study. The Alinity c automaton exhibited the necessary analytical performance to ensure accurate and dependable determination of phosphorus levels. <strong>Discussion</strong>: Ensuring accurate and reliable results, the verification of the serum phosphorus determination method in the medical laboratory is crucial. This process entails implementing quality control measures, calibration, and comparing with established reference methods. It guarantees that the laboratory's phosphorus testing method is precise, accurate, and compliant with industry standards, thereby upholding the quality of patient care. <strong>Conclusion:</strong> The verification study of the serum phosphorus determination method yielded satisfactory results, providing high reliability to the test results from the central laboratory at Mohammed VI University Hospital of Oujda. This verification study serves as a strong foundation in the accreditation process, ensuring the accuracy and quality of laboratory testing, and enhancing the overall reliability of patient care
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Abir Yahyaoui, Issam Mokhtari, Abderazak Saddari, et al. "Verification of analytical performance of the microalbumin assay on the Abbott Alinity ci®: Experience of the central laboratory Mohammed VI Oujda." World Journal of Biology Pharmacy and Health Sciences 13, no. 3 (2023): 101–5. http://dx.doi.org/10.30574/wjbphs.2023.13.3.0123.

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The verification of analytical methods is a requirement of the standard NF EN ISO 15 189. It consists of evaluating the performance of an analytical method according to a well-defined protocol and then comparing it with pre-established analytical objectives. The mastery of this approach must be the concern of any biologist. Through this work we present the results of the protocol of verification of the method of determination of microalbumin by comparing two automats: Alinity ci ® and Architect ci-8200® Abbott. Microalbumin monitoring in urine is an important element in the treatment of diabetes mellitus types I and II. It can also be used to predict diabetic nephropathy, which is the leading cause of death in people with insulin-dependent diabetes.
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Houria, MADANI, HIMRI Amina, EL MOUJTAHIDE Dounia, Houcine SEBBAR El, and CHOUKRI Mohammed. "Verification of the insulin dosage method using Abbott Alinity ci®: experience of the biochemistry laboratory, CHU Mohammed IV Oujda, Morocco." GSC Biological and Pharmaceutical Sciences 28, no. 1 (2024): 164–70. https://doi.org/10.5281/zenodo.13458664.

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<strong>Introduction</strong>: The aim of our study was to evaluate the analytical performance of the insulin dosage method, which was performed by the Alinity ci&reg; automated system in the biochemistry laboratory of the Mohammed VI University Hospital in Oujda. Insulin acts as an essential role in regulating the body's energy supply, mainly by balancing blood sugar levels via the storage of glucose in the liver, muscles and adipose tissue. <strong>Materials and methods:&nbsp;</strong>We carried out a study of the performance of the Alinity ci&reg; automated system, assessing repeatability and reproducibility in accordance with the COFRAC GTA 04 accreditation technical guide, which meets the quality requirements of standard ISO 15&nbsp;189. <strong>Results:&nbsp;</strong>The results of our study show satisfactory repeatability for the three levels (Low; Medium; High) with CV1 = 2.44 %, CV2 = 1.76 %, CV3 = 1.33 %. The reproducibility of insulin was also satisfactory, with respect to the coefficient of variation (CV) for the three levels (Low, Medium, High), respectively CV1 = 3.16 %, CV2 = 5.78 %, CV3 = 2.88 %. <strong>Conclusion:&nbsp;</strong>The reliability of our laboratory's insulin assay results is demonstrated by the satisfactory results obtained in our study, which comply with RICOS and FSCB recommendations.
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Houria, MADANI, HIMRI Amina, EL MOUJTAHIDE Dounia, Houcine SEBBAR El, and CHOUKRI Mohammed. "Verification of the insulin dosage method using Abbott Alinity ci®: experience of the biochemistry laboratory, CHU Mohammed IV Oujda, Morocco." GSC Biological and Pharmaceutical Sciences 28, no. 1 (2024): 164–70. https://doi.org/10.5281/zenodo.13458664.

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<strong>Introduction</strong>: The aim of our study was to evaluate the analytical performance of the insulin dosage method, which was performed by the Alinity ci&reg; automated system in the biochemistry laboratory of the Mohammed VI University Hospital in Oujda. Insulin acts as an essential role in regulating the body's energy supply, mainly by balancing blood sugar levels via the storage of glucose in the liver, muscles and adipose tissue. <strong>Materials and methods:&nbsp;</strong>We carried out a study of the performance of the Alinity ci&reg; automated system, assessing repeatability and reproducibility in accordance with the COFRAC GTA 04 accreditation technical guide, which meets the quality requirements of standard ISO 15&nbsp;189. <strong>Results:&nbsp;</strong>The results of our study show satisfactory repeatability for the three levels (Low; Medium; High) with CV1 = 2.44 %, CV2 = 1.76 %, CV3 = 1.33 %. The reproducibility of insulin was also satisfactory, with respect to the coefficient of variation (CV) for the three levels (Low, Medium, High), respectively CV1 = 3.16 %, CV2 = 5.78 %, CV3 = 2.88 %. <strong>Conclusion:&nbsp;</strong>The reliability of our laboratory's insulin assay results is demonstrated by the satisfactory results obtained in our study, which comply with RICOS and FSCB recommendations.
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45

Houria, MADANI, HIMRI Amina, EL MOUJTAHIDE Dounia, Houcine SEBBAR El, and CHOUKRI Mohammed. "Verification of the insulin dosage method using Abbott Alinity ci®: experience of the biochemistry laboratory, CHU Mohammed IV Oujda, Morocco." GSC Biological and Pharmaceutical Sciences 28, no. 1 (2024): 164–70. https://doi.org/10.5281/zenodo.13458664.

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Abstract:
<strong>Introduction</strong>: The aim of our study was to evaluate the analytical performance of the insulin dosage method, which was performed by the Alinity ci&reg; automated system in the biochemistry laboratory of the Mohammed VI University Hospital in Oujda. Insulin acts as an essential role in regulating the body's energy supply, mainly by balancing blood sugar levels via the storage of glucose in the liver, muscles and adipose tissue. <strong>Materials and methods:&nbsp;</strong>We carried out a study of the performance of the Alinity ci&reg; automated system, assessing repeatability and reproducibility in accordance with the COFRAC GTA 04 accreditation technical guide, which meets the quality requirements of standard ISO 15&nbsp;189. <strong>Results:&nbsp;</strong>The results of our study show satisfactory repeatability for the three levels (Low; Medium; High) with CV1 = 2.44 %, CV2 = 1.76 %, CV3 = 1.33 %. The reproducibility of insulin was also satisfactory, with respect to the coefficient of variation (CV) for the three levels (Low, Medium, High), respectively CV1 = 3.16 %, CV2 = 5.78 %, CV3 = 2.88 %. <strong>Conclusion:&nbsp;</strong>The reliability of our laboratory's insulin assay results is demonstrated by the satisfactory results obtained in our study, which comply with RICOS and FSCB recommendations.
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46

Houria, MADANI, HIMRI Amina, EL MOUJTAHIDE Dounia, Houcine SEBBAR El, and CHOUKRI Mohammed. "Verification of the insulin dosage method using Abbott Alinity ci®: experience of the biochemistry laboratory, CHU Mohammed IV Oujda, Morocco." GSC Biological and Pharmaceutical Sciences 28, no. 1 (2024): 164–70. https://doi.org/10.5281/zenodo.13458664.

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Abstract:
<strong>Introduction</strong>: The aim of our study was to evaluate the analytical performance of the insulin dosage method, which was performed by the Alinity ci&reg; automated system in the biochemistry laboratory of the Mohammed VI University Hospital in Oujda. Insulin acts as an essential role in regulating the body's energy supply, mainly by balancing blood sugar levels via the storage of glucose in the liver, muscles and adipose tissue. <strong>Materials and methods:&nbsp;</strong>We carried out a study of the performance of the Alinity ci&reg; automated system, assessing repeatability and reproducibility in accordance with the COFRAC GTA 04 accreditation technical guide, which meets the quality requirements of standard ISO 15&nbsp;189. <strong>Results:&nbsp;</strong>The results of our study show satisfactory repeatability for the three levels (Low; Medium; High) with CV1 = 2.44 %, CV2 = 1.76 %, CV3 = 1.33 %. The reproducibility of insulin was also satisfactory, with respect to the coefficient of variation (CV) for the three levels (Low, Medium, High), respectively CV1 = 3.16 %, CV2 = 5.78 %, CV3 = 2.88 %. <strong>Conclusion:&nbsp;</strong>The reliability of our laboratory's insulin assay results is demonstrated by the satisfactory results obtained in our study, which comply with RICOS and FSCB recommendations.
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47

Abir, Yahyaoui, Mokhtari Issam, Saddari Abderazak, et al. "Verification of analytical performance of the microalbumin assay on the Abbott Alinity ci®: Experience of the central laboratory Mohammed VI Oujda." World Journal of Biology Pharmacy and Health Sciences 13, no. 3 (2023): 101–5. https://doi.org/10.5281/zenodo.8031619.

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Abstract:
The verification of analytical methods is a requirement of the standard NF EN ISO 15 189. It consists of evaluating the performance of an analytical method according to a well-defined protocol and then comparing it with pre-established analytical objectives. The mastery of this approach must be the concern of any biologist. Through this work we present the results of the protocol of verification of the method of determination of microalbumin by comparing two automats: Alinity ci&nbsp;<sup>&reg;</sup>&nbsp;and Architect ci-8200<sup>&reg;</sup>&nbsp;Abbott. Microalbumin monitoring in urine is an important element in the treatment of diabetes mellitus types I and II. It can also be used to predict diabetic nephropathy, which is the leading cause of death in people with insulin-dependent diabetes.
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48

Oumaima Kharkhach, Kaoutar Jamal, Dounia Elmoujtahide, El Houcine Sebbar та Mohammed Choukri. "Verification of the analytical performance of the serum Beta-2 microglobulin (β2M) assay on the Abbott Alinity ci®: Experience of the Biochemistry Laboratory of the Mohammed VI University Hospital, Oujda". GSC Biological and Pharmaceutical Sciences 30, № 3 (2025): 280–85. https://doi.org/10.30574/gscbps.2025.30.3.0116.

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The verification of analytical performance is a critical step in ensuring the reliability and accuracy of laboratory assays. This study aims to evaluate the analytical performance of the beta-2 microglobulin (β2M) immunoassay on the Abbott Alinity ci® platform in the central laboratory of Mohammed VI University Hospital of Oujda over a 30-day duration. The study assesses key analytical parameters, including precision, reproducibility, and repeatability against established standards, based on ISO 15189 accreditation guidelines. Results show low coefficients of variation (CV), with reproducibility ranging from 2.36% to 2.94% and repeatability from 1.00%to 2.55%, meeting the stringent criteria set by recognized professional societies. These findings confirm the robustness and reliability of the method and validate the analytical performance of the β2M assay, underscoring its suitability for clinical use.
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49

Bohn, M. K., S. Wilson, and K. Adeli. "M279 Pediatric reference interval verification for special chemistry, immunoassay, and cancer markers on the Abbott Alinity CI system." Clinica Chimica Acta 530 (May 2022): S392. http://dx.doi.org/10.1016/j.cca.2022.04.988.

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50

Bertholet, C., M. Lamtiri Laarif, L. Vranken, R. Gadisseur, S. Delcour, and E. Cavalier. "Verification of the reference intervals proposed by Abbott on Alinity CI in a population of healthy subjects from Liege, Belgium." Clinica Chimica Acta 493 (June 2019): S13. http://dx.doi.org/10.1016/j.cca.2019.03.036.

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