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Journal articles on the topic 'ABC model of opportunity'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Rohde, Carsten. "Activity-based costing revisited by managerial economics logic." Corporate Ownership and Control 4, no. 4 (2007): 300–309. http://dx.doi.org/10.22495/cocv4i4c2p5.

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This paper identifies a number of differences in the treatment of costs and expenditures in activitybased costing (ABC) and a management accounting system based on the managerial economics model.At present, ex ante ABC models incorporating a resource consumption model and a resource spending model with what-if capabilities are recommended for activity-based budgeting in order to make betterinformed strategic and operational decisions. Using a numerical example, the paper demonstrates the resulting cost distortions in ex ante ABC models and their profitability segments when costs are nonlinear

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Shelina Putri Kurniadi, Pudji Astuti, and Dadang Surjasa. "Model Mitigasi Risiko Pada Proses Bisnis Order Fulfilment di PT ABC." JURNAL TEKNIK INDUSTRI 13, no. 2 (2023): 145–51. http://dx.doi.org/10.25105/jti.v13i2.17542.

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Intisari— PT ABC adalah perusahaan Fast Moving Consumer Goods (FMCG) yang memproduksi dan mendistribusikan empat kategori produk berupa produk kecantikan, makanan, home care, dan personal care. Terdapat dua channel customer yaitu modern trade (MT) dan distributive trade (DT). Permasalahan terjadi pada proses bisnis order fulfilment di customer MT yaitu adanya peningkatan lead time pembayaran sejak tahun 2019 hingga 2022. Proses bisnis order fulfilment terdiri dari delapan sub proses dimulai dari sub proses customer order hingga sub proses pembayaran customer, sehingga tujuan dari penelitian in

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Pradel, R., O. Gimenez, and J. D. Lebreton. "Principles and interest of GOF tests for multistate capture-recapture models." Animal Biodiversity and Conservation 28, no. 2 (2005): 189–204. http://dx.doi.org/10.32800/abc.2005.28.0189.

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Optimal goodness–of–fit procedures for multistate models are new. Drawing a parallel with the corresponding single–state procedures, we present their singularities and show how the overall test can be decomposed into interpretable components. All theoretical developments are illustrated with an application to the now classical study of movements of Canada geese between wintering sites. Through this application, we exemplify how the interpretable components give insight into the data, leading eventually to the choice of an appropriate general model but also sometimes to the invalidation of the

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Kaur, Hundeep, Andrea Lakatos, Roberta Spadaccini, et al. "The ABC exporter MsbA probed by solid state NMR – challenges and opportunities." Biological Chemistry 396, no. 9-10 (2015): 1135–49. http://dx.doi.org/10.1515/hsz-2015-0119.

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Abstract ATP binding cassette (ABC) transporters form a superfamily of integral membrane proteins involved in translocation of substrates across the membrane driven by ATP hydrolysis. Despite available crystal structures and extensive biochemical data, many open questions regarding their transport mechanisms remain. Therefore, there is a need to explore spectroscopic techniques such as solid state NMR in order to bridge the gap between structural and mechanistic data. In this study, we investigate the feasibility of using Escherichia coli MsbA as a model ABC transporter for solid state NMR stu

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Avdeyev, Andrey, Valeriy Benberin, Nasrulla Shanazarov, et al. "OP16 Assessing The Viability Of Medical Equipment Procurement In Hospital." International Journal of Technology Assessment in Health Care 35, S1 (2019): 2–3. http://dx.doi.org/10.1017/s0266462319000898.

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IntroductionABC-VEN analysis is an easy method of clinical and economic analysis on the costs of drug coverage and an important tool for monitoring and ensuring the rational use of medicines. However, this methodology is difficult to apply in assessing the viability of medical equipment procurement (MEP) in hospital. Using a combined model of ABC analysis and Multiple criteria decision analysis (MCDA) may be more appropriate to apply to MEP.MethodsWe created five standardized criteria, which present the main results of assessment of the viability of MEP for implementing new health technologies

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Pressiat, Claire, Evelyne Dainguy, Jean-Marc Tréluyer, et al. "Comparison of three galenic forms of lamivudine in young West African children living with Human Immunodeficiency Virus." Antiviral Therapy 26, no. 6-8 (2021): 134–40. http://dx.doi.org/10.1177/13596535211058267.

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Background Few pharmacokinetic data were reported on dispersible tablets despite their increasing use. One hundred fifty HIV-infected children receiving lamivudine were enrolled in the MONOD ANRS 12,206 trial. Three galenic forms were administered: liquid formulation, tablet form and dispersible scored tablet. Method HIV-infected children <4 years old were enrolled in the MONOD ANRS 12,206 trial designed to assess the simplification of a successful 12-months lopinavir-based antiretroviral treatment with efavirenz. Lamivudine plasma concentrations were analysed using nonlinear mixed effects

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Büyüközkan, Gülçin, and Öykü Ilıcak. "Integrated SWOT analysis with multiple preference relations." Kybernetes 48, no. 3 (2019): 451–70. http://dx.doi.org/10.1108/k-12-2017-0512.

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Purpose SWOT (strengths, weaknesses, opportunities, threats) analysis is a powerful approach for evaluating the strengths and weaknesses of an organization with an internal perspective. The approach also takes into account the opportunities and the threats from an external point of view. These features make SWOT a commonly used approach in strategic management. The purpose of this paper is to propose an integrated SWOT analysis with multiple preference relations technique, to show the application of the proposed methodology, to prioritize the strategic factors and to present alternative strate

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Meucci, V., and R. F. Ashman. "Membrane defects of the tolerant B cell. IV. Failure to accelerate antigen receptor loss." Journal of Immunology 136, no. 7 (1986): 2339–41. http://dx.doi.org/10.4049/jimmunol.136.7.2339.

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Abstract Mechanisms of immunologic tolerance affecting antibody responses include conditions extrinsic to the B cell such as dominant suppression by T cells (1), regulation by anti-idiotype (2), and tolerance in T helper cell populations (3). But tolerance can also result from changes in the antigen-reactive B cells such as their deletion (4), or that mysterious process by which they become "intrinsically tolerant", i.e., refractory to stimulation (5). One approach to learning more about the mechanism of intrinsic tolerance at the level of cell physiology is to determine which of the activatio

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Ridwan, Ridwan, and Susanto Susanto sudiro. "Pemodelan Manajemen Proyek Rekayasa Dolly Kitting Sebagai Alat Bantu Feeding Material di Jalur Produksi Perakitan Mobil." Teknobiz : Jurnal Ilmiah Program Studi Magister Teknik Mesin 10, no. 2 (2020): 14–21. http://dx.doi.org/10.35814/teknobiz.v10i2.1458.

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The development of the Indonesian Automotive Industry in 2019 is expected to remain significant, this is shown from the sales of various brand vehicles in Indonesia which experienced an increase in 2018. To meet existing market demand, automotive companies need additional new investment in the form of various production equipment to anticipate schedules planned production. One type of production aids needed in car assembly lines is Rack, Tolley, Box (RTB) and Dolly Kitting. The demand for production aids is a real market opportunity, and this must be utilized by the local industry to take part

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Chaponniere, Paulette A., and Laura E. Hall. "Coping: “This Is More Than a Trip—It Is a Journey”." Western Journal of Nursing Research 42, no. 1 (2019): 41–49. http://dx.doi.org/10.1177/0193945919843138.

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A 2-week community health clinical experience in Ghana, Africa, provided undergraduate nursing students a study abroad opportunity to expand their cross-cultural skills. Journal entries ( N = 512) of four cohorts were analyzed for common themes using Atlas.ti 7 in this descriptive qualitative study. No emphasis was placed on how to cope with cultural shock in Ghana, nor any attempt made to teach effective coping skills during the trips. Bochner’s ABC cultural learning response model provided the framework for grouping themes. Positive coping skills included the need for control, humor, normali

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Rahman, Ardi Abdul, and Anas Alhifni. "ANALISIS KEBUTUHAN NELAYAN TERHADAP PEMBIAYAAN LKMS." JURNAL SYARIKAH : JURNAL EKONOMI ISLAM 4, no. 2 (2019): 152. http://dx.doi.org/10.30997/jsei.v4i2.1506.

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Tujuan penelitian ini adalah untuk mengetahui produk pembiayaan yang sesuai dengan para nelayan sehingga dapat memberikan solusi kepada para nelayan untuk menambah modal tambahan bagi nelayan kecil melalui LKMS. Metode analisis dalam penelitian ini menggunakan metode analisis kebutuhan Activity Based Costing (ABC) dan Benefit Cost Opportunity Risk (BCOR) dengan teknik pengumpulan data observasi non participant, wawancara, kuesioner, dan dokumentasi. Hasil dari penelitian ini adalah nelayan membutuhkan pembiayaan untuk permodalan terutama untuk perbaikan/pemeliharaan dan pembelian kapal serta a

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Nguyen, Khai The, Phuong Ngoc Duy Nguyen, Cuong Quoc Tran, and Truc Thi Thanh Do. "Green human resource management and employee pro-environmental behaviors: The role of individual green value." HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE - ECONOMICS AND BUSINESS ADMINISTRATION 14, no. 2 (2024): 45–63. http://dx.doi.org/10.46223/hcmcoujs.econ.en.14.2.3129.2024.

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This quantitative study is aimed at exploring the effect of Green Human Resource Management (GHRM) practices on employee Pro-Environmental Behaviors (PEB). Our conceptual model was developed based on the Ability, Motivation, and Opportunity (AMO) framework and the Attitude-Behavior-Context theory (ABC). Our model was tested using data from 696 full-time medical staff working in Vietnamese hospitals. In order to fully understand how GHRM practices, Green knowledge sharing, individual green value, and employee pro-environmental behaviors are related, structural equation modeling is combined with

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Quynh Mai, Vu, Hoang Van Minh, Nguyen Truong Nam, et al. "Cost Analysis of Community-Based Smoking Cessation Services in Vietnam: A Cluster-Randomized Trial." Health Services Insights 14 (January 2021): 117863292110309. http://dx.doi.org/10.1177/11786329211030932.

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The study aimed to estimate the cost for developing and implementing 2 smoking cessation service delivery models that were evaluated in a 2-arm cluster randomized trial in Commune Health Centers (CHCs) in Vietnam. In the first model (4As) CHC providers were trained to ask about tobacco use, advise smokers to quit, assess readiness to quit, and assist with brief counseling. The second model included the 4As plus a referral to Village Health Workers (VHWs) who were trained to provide multisession home-based counseling (4As + R). An activity-based ingredients (ABC-I) costing approach with a healt

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Ramoglou, Stratos, and Jeff McMullen. ""WHAT IS AN OPPORTUNITY?": FROM THEORETICAL MYSTIFICATION TO EVERYDAY UNDERSTANDING." Academy of Management Review 49, no. 2 (2024): 273–98. https://doi.org/10.5465/amr.2020.0335.

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Expressions about opportunities are used unproblematically in everyday contexts. Yet, the question “What is an opportunity?” has posed a difficult riddle in the academic study of entrepreneurship. Drawing on the philosophy of Ludwig Wittgenstein, we explain that such perplexities are common when words are removed from ordinary language and intellectuals try to grasp what they name. Approaching the opportunity riddle differently, we ask, “How do entrepreneurs use the word opportunity?” and elucidate an actualization theory of entrepreneurship attuned to the everyday unde

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Lee, Kyung-Mi, and Kyoung-Ok Park. "A Literature Review on the Experience of Barriers to Opportunity of AAC Users based on the Participation Model." Journal of Special Education & Rehabilitation Science 61, no. 1 (2022): 177–204. http://dx.doi.org/10.23944/jsers.2022.03.61.1.7.

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Fadiyanto, Guruh Ahmad. "Transformation Of Polri Strategy With Precision Principles In Preventing And Handling Vertical Conflict In Mimika Regency Central Papua Province." International Journal of Progressive Sciences and Technologies 41, no. 2 (2023): 489. http://dx.doi.org/10.52155/ijpsat.v41.2.5790.

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The phenomenon of vertical conflict is very diverse, starting from the social, cultural, political and economic aspects of various lives which are triggered by differences between the Amungme tribe living in mountainous areas and the Kamoro tribe in coastal areas. Apart from these two tribes, there are still five kinship tribes including; Dani/Lani, Damal, Mee, Nduga and Moni according to characteristics which are considered detrimental and disturbing issues and even violate the rules and norms that apply to tribes still have various kinds of problems until now there are still tribal wars and

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Kelleher, Joseph, Laurent Audoly, Veronica Campbell, et al. "Targeted Degradation of IRAK4 Protein Via Heterobifunctional Small Molecules for Treatment of MYD88 Mutant Lymphoma." Blood 132, Supplement 1 (2018): 2953. http://dx.doi.org/10.1182/blood-2018-99-120148.

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Abstract Recurrent mutations in the scaffolding protein MYD88 are present in 30-40% of activated B cell diffuse lymphocytic B cell lymphoma (ABC-DLBCL)(Ngo et al. Nature 2011). MYD88 links activated interleukin 1 receptor (IL1R) and Toll-like receptors (TLRs) to downstream effectors by nucleating assembly of the Myddosome, a multi-protein complex containing MYD88, the protein kinases IRAK4 and IRAK1 and the pseudokinase IRAK2, via oligomerization of the N-terminal Death Domains in each of these proteins (Motshwene et al. JBC 2009; Lin, Lo and Wu. Nature 2010). The most prevalent MYD88 mutation

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Ilyukha, Olga Pavlovna, and Yurii Gennadievich Shikalov. "MODELS OF FAMILY AND GENDER RELATIONS IN KARELIAN AND FINNISH BOOKS FOR TEACHING READING IN THE ETHNO-CULTURAL CONTEXT OF THE LATE 20 - EARLY 21 CENTURIES." Yearbook of Finno-Ugric Studies 16, no. 1 (2022): 165–79. http://dx.doi.org/10.35634/2224-9443-2022-16-1-165-179.

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The dynamic changes of the last decades taking place in society, including the ethno-cultural sphere, are reflected in the content of ABC-books and other books for teaching children to read. These specific products of culture by means of their native language convey an authoritative picture of the world and contribute to the formation of ethnic, gender and other levels of identity. In this article, the texts and illustrations used for the analysis reveal the theme of family and gender relations in the conditions of the last period of modern history. Based on the materials of books used in educ

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Almasoud, Ahmed S., Hanan Abdullah Mengash, Majdy M. Eltahir, Nabil Sharaf Almalki, Mrim M. Alnfiai, and Ahmed S. Salama. "Automated Arrhythmia Classification Using Farmland Fertility Algorithm with Hybrid Deep Learning Model on Internet of Things Environment." Sensors 23, no. 19 (2023): 8265. http://dx.doi.org/10.3390/s23198265.

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In recent years, the rapid progress of Internet of Things (IoT) solutions has offered an immense opportunity for the collection and dissemination of health records in a central data platform. Electrocardiogram (ECG), a fast, easy, and non-invasive method, is generally employed in the evaluation of heart conditions that lead to heart ailments and the identification of heart diseases. The deployment of IoT devices for arrhythmia classification offers many benefits such as remote patient care, continuous monitoring, and early recognition of abnormal heart rhythms. However, it is challenging to di

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Aithal, P. S., V. T. Shailasri, and Kumar P. M. Suresh. "A New ABCD Technique to Analyze Business Models & Concepts." International Journal of Management, IT and Engineering (IJMIE) 5, no. 4 (2015): 409–23. https://doi.org/10.5281/zenodo.61652.

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Various techniques are used to analyze individual characteristics or organizational effectiveness like SWOT analysis, SWOC analysis, PEST analysis etc. These techniques provide an easy and systematic way of identifying various issues affecting a system and provides an opportunity for further development. Whereas these provide a broad-based assessment of individual institutions and systems, it suffers limitations while applying to business context. The success of any business model depends on how a company makes a profit by specifying its position in the value chain. Therefore identifying suita

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Patel, Rupal, and Travis T. Threats. "One's Voice: A Central Component of Personal Factors in Augmentative and Alternative Communication." Perspectives of the ASHA Special Interest Groups 1, no. 12 (2016): 94–98. http://dx.doi.org/10.1044/persp1.sig12.94.

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Augmentative and alternative communication (AAC) devices have opened the gates to interaction for those with severe communication impairments. In the assessment and intervention, all components of the World Health Organization's International Classification of Functioning, Disability, and Health (ICF) should be addressed. However, an important Personal Factor to full integration has been largely ignored—that of one's voice. Each one of us has a unique voice that conveys our age, cultural background and personality—it's how people know and remember you. These affordances of the natural voice ar

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Al-qaness, Mohammed A. A., Ahmed M. Helmi, Abdelghani Dahou, and Mohamed Abd Elaziz. "The Applications of Metaheuristics for Human Activity Recognition and Fall Detection Using Wearable Sensors: A Comprehensive Analysis." Biosensors 12, no. 10 (2022): 821. http://dx.doi.org/10.3390/bios12100821.

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In this paper, we study the applications of metaheuristics (MH) optimization algorithms in human activity recognition (HAR) and fall detection based on sensor data. It is known that MH algorithms have been utilized in complex engineering and optimization problems, including feature selection (FS). Thus, in this regard, this paper used nine MH algorithms as FS methods to boost the classification accuracy of the HAR and fall detection applications. The applied MH were the Aquila optimizer (AO), arithmetic optimization algorithm (AOA), marine predators algorithm (MPA), artificial bee colony (ABC)

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Wagers, Patrick O., Kristin M. Tiemann, Kerri L. Shelton, et al. "Imidazolium Salts as Small-Molecule Urinary Bladder Exfoliants in a Murine Model." Antimicrobial Agents and Chemotherapy 59, no. 9 (2015): 5494–502. http://dx.doi.org/10.1128/aac.00881-15.

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ABSTRACTWe present a novel family of small-molecule urinary bladder exfoliants that are expected to be of great value in preclinical studies of urologic conditions and have improved potential for translation compared with prior agents. There is broad urologic interest in the therapeutic potential of such exfoliating agents. The primary agent used in preclinical models, the cationic peptide protamine sulfate (PS), has limited translational potential due to concerns including systemic adverse reactions and bladder tissue injury. Intravesical application of a safe, systemically nontoxic exfoliant

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Cummings, Jason E., Adam J. Beaupre, Susan E. Knudson, et al. "Substituted Diphenyl Ethers as a Novel Chemotherapeutic Platform against Burkholderia pseudomallei." Antimicrobial Agents and Chemotherapy 58, no. 3 (2013): 1646–51. http://dx.doi.org/10.1128/aac.02296-13.

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ABSTRACTIdentification of a novel class of anti-Burkholderiacompounds is key in addressing antimicrobial resistance to current therapies as well as naturally occurring resistance. The FabI enoyl-ACP reductase inBurkholderiais an underexploited target that presents an opportunity for development of a new class of inhibitors. A library of substituted diphenyl ethers was used to identify FabI1-specific inhibitors for assessment inBurkholderia pseudomallei ex vivoand murine efficacy models. Active FabI1 inhibitors were identified in a two-stage format consisting of percent inhibition screening and

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Patanè, Luca, Francesca Sapuppo, Gabriele Rinaldi, Antonio Comi, Giuseppe Napoli, and Maria Gabriella Xibilia. "Model Identification and Transferability Analysis for Vehicle-to-Grid Aggregate Available Capacity Prediction Based on Origin–Destination Mobility Data." Energies 17, no. 24 (2024): 6374. https://doi.org/10.3390/en17246374.

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Vehicle-to-grid (V2G) technology is emerging as an innovative paradigm for improving the electricity grid in terms of stabilization and demand response, through the integration of electric vehicles (EVs). A cornerstone in this field is the estimation of the aggregated available capacity (AAC) of EVs based on available data such as origin–destination mobility data, traffic and time of day. This paper considers a real case study, consisting of two aggregation points, identified in the city of Padua (Italy). As a result, this study presents a new method to identify potential applications of V2G b

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Simpson, Julie A., Emmeline R. Watkins, Ric N. Price, Leon Aarons, Dennis E. Kyle, and Nicholas J. White. "Mefloquine Pharmacokinetic-Pharmacodynamic Models: Implications for Dosing and Resistance." Antimicrobial Agents and Chemotherapy 44, no. 12 (2000): 3414–24. http://dx.doi.org/10.1128/aac.44.12.3414-3424.2000.

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ABSTRACT Antimalarial resistance develops and spreads when spontaneously occurring mutant malaria parasites are selected by concentrations of antimalarial drug which are sufficient to eradicate the more sensitive parasites but not those with the resistance mutation(s). Mefloquine, a slowly eliminated quinoline-methanol compound, is the most widely used drug for the treatment of multidrug-resistant falciparum malaria. It has been used at doses ranging between 15 and 25 mg of base/kg of body weight. Resistance to mefloquine has developed rapidly on the borders of Thailand, where the drug has bee

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Thewjitcharoen, Yotsapon, Ekgaluck Wanothayaroj, Soontaree Nakasatien, et al. "Atypical Diabetes Mellitus Associated With Kabuki Syndrome: A Model of Epigenetic Disturbance in Insulin Resistance?" Journal of the Endocrine Society 5, Supplement_1 (2021): A369. http://dx.doi.org/10.1210/jendso/bvab048.751.

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Abstract Background: Kabuki syndrome (KS) is a genetically heterogeneous disorder characterized by striking facial features similar to make-up of actors in Japanese Kabuki performance together with multi-organ defects. The first identified and most frequently involved gene is KMT2D which encodes a histone H3K4 methyltransferase. Even though KS is a rare syndrome and associated diabetes has been rarely reported, both type 1 DM and type 2 DM had been previously reported. Understanding the function of the genes that lead to KS opens up the possibility of targeted therapies for diabetes. Clinical

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Vaez, Kelly, Lauren Diegel-Vacek, Catherine Ryan, and Pamela Martyn-Nemeth. "Evaluating Diabetes Care for Patients With Serious Mental Illness Using the Chronic Care Model." Health Services Research and Managerial Epidemiology 4 (January 1, 2017): 233339281773420. http://dx.doi.org/10.1177/2333392817734206.

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People with serious mental illness (SMI) have a higher incidence of type 2 diabetes mellitus (T2DM) and shorter life span due to medical health problems. The chronic care model (CCM) has been used to improve care of patients with T2DM. One clinical organization that provided primary care to patients with SMI had excellent diabetes outcomes but did not have information on how they achieved those outcomes. Thus, we conducted a pilot study chart review for 30 patients with T2DM and SMI to determine how well the clinic’s system aligned with the overall CCM components and which components correlate

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Miller, Keith, Alexander John O'Neill, and Ian Chopra. "Escherichia coli Mutators Present an Enhanced Risk for Emergence of Antibiotic Resistance during Urinary Tract Infections." Antimicrobial Agents and Chemotherapy 48, no. 1 (2004): 23–29. http://dx.doi.org/10.1128/aac.48.1.23-29.2004.

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ABSTRACT Mutators may present an enhanced risk for the emergence of antibiotic resistance in bacteria during chemotherapy. Using Escherichia coli mutators as a model, we evaluated their ability to develop resistance to antibiotics routinely used for the treatment of urinary tract infections (UTIs). Under conditions that simulate therapeutic drug concentrations in humans, low-level resistance to trimethoprim, gentamicin, and cefotaxime emerged more frequently in mutators than normal strains. Resistance to trimethoprim in both cell types arose from a single point mutation in folA (Ile94→Leu) and

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Sissons, Helen, and Thomas Cochrane. "Introducing Immersive Reality into the Journalism Curriculum." Pacific Journal of Technology Enhanced Learning 2, no. 1 (2019): 7. http://dx.doi.org/10.24135/pjtel.v2i1.27.

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Following the introduction of the Google Cardboard virtual reality (VR) head mounted display (HMD) in 2014, mainstream journalism began exploring the potential of VR to transform news storytelling as an immersive experience (Lalwani, 2015; Somaiya, 2015). However, unlike the transformative impact of social media on journalism and journalism education (Mulrennan, 2017), VR has taken several years for this to filter into the curriculum of journalism higher education. AUT’s journalism programme includes a final semester, capstone, assessment in which students produce a piece of long-form immersiv

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Semoun, Oudy, Sandrine Marchand, Nicolas Grégoire, et al. "Modeling Approach To Characterize Intraocular Doripenem Pharmacokinetics after Intravenous Administration to Rabbits, with Tentative Extrapolation to Humans." Antimicrobial Agents and Chemotherapy 56, no. 7 (2012): 3531–34. http://dx.doi.org/10.1128/aac.06329-11.

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ABSTRACTThe aim of this study was to determine the penetration of doripenem administered intravenously into the rabbit aqueous and vitreous humors. Nineteen New Zealand White rabbits received a 20-mg dose of doripenem intravenously over 60 min. Specimens of aqueous humor, vitreous humor, and blood were obtained 30 min (n= 5), 1 h (n= 5), 2 h (n= 5), and 3 h (n= 4) after the beginning of the infusion and analyzed by high-performance liquid chromatography (HPLC). A pharmacokinetic (PK) model was developed to fit the experimental data. Doripenem concentrations in aqueous humor were lower than tho

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Shushok, Frank. "The Opportunity GapChasm." About Campus 20, no. 4 (2015): 2. http://dx.doi.org/10.1002/abc.21199.

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D'Elia, Riccardo V., Thomas R. Laws, Alun Carter, Roman Lukaszewski, and Graeme C. Clark. "Targeting the “Rising DAMP” during a Francisella tularensis Infection." Antimicrobial Agents and Chemotherapy 57, no. 9 (2013): 4222–28. http://dx.doi.org/10.1128/aac.01885-12.

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ABSTRACTAntibiotic efficacy is greatly enhanced the earlier it is administered following infection with a bacterial pathogen. However, in a clinical setting antibiotic treatment usually commences following the onset of symptoms, which in some cases (e.g., biothreat agents) may be too late. In a BALB/c murine intranasal model of infection forFrancisella tularensisSCHU S4 infection, we demonstrate during a time course experiment that proinflammatory cytokines and the damage-associated molecular pattern HMGB1 were not significantly elevated above naive levels in tissue or sera until 72 h postinfe

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Li, Si-Yang, Scott M. Irwin, Paul J. Converse, Khisi E. Mdluli, Anne J. Lenaerts, and Eric L. Nuermberger. "Evaluation of Moxifloxacin-Containing Regimens in Pathologically Distinct Murine Tuberculosis Models." Antimicrobial Agents and Chemotherapy 59, no. 7 (2015): 4026–30. http://dx.doi.org/10.1128/aac.00105-15.

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ABSTRACTIn the recently concluded REMox-TB trial, two 4-month moxifloxacin-containing regimens did not meet the criteria for noninferiority compared to the current 6-month first-line regimen to treat tuberculosis (TB). Despite the disappointing result, this phase 3 clinical trial provides a rare opportunity to gauge the predictive accuracy of the nonclinical models used to support regimen development. In parallel with the REMox-TB trial, we compared the efficacy of the same three regimens against chronic TB infection in the commonly used BALB/c mouse strain and in C3HeB/FeJ mice, which have at

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Wang, Ya-Juan, Dong Lu, Yi-Bin Xu, et al. "A Novel Pyridazinone Derivative Inhibits Hepatitis B Virus Replication by Inducing Genome-Free Capsid Formation." Antimicrobial Agents and Chemotherapy 59, no. 11 (2015): 7061–72. http://dx.doi.org/10.1128/aac.01558-15.

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ABSTRACTHere we first identified a novel pyridazinone derivative, compound 3711, as a nonnucleosidic hepatitis B virus (HBV) inhibitor in a cell model system. 3711 decreased extracellular HBV DNA levels by 50% (50% inhibitory concentration [IC50]) at 1.5 ± 0.2 μM and intracellular DNA levels at 1.9 ± 0.1 μM, which demonstrated antiviral activity at levels far below those associated with toxicity. Both the 3TC/ETV dually resistant L180M/M204I mutant and the adefovir (ADV)-resistant A181T/N236T mutant were as susceptible to 3711 as wild-type HBV. 3711 treatment induced the formation of genome-fr

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Mainguy, B., L. Mehl-Madrona, and D. Ruben. "Modeling the appearance and progression of cognitive impairment." European Psychiatry 64, S1 (2021): S138—S139. http://dx.doi.org/10.1192/j.eurpsy.2021.381.

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IntroductionIt remains difficult to predict which individuals will develop cognitive impairment and progress to major neurocognitive disorders. Prevention studies suffer from the long time frames and the manner in which this topic does not lend itself to randomized, double-blinded controlled trials.ObjectivesWe aimed to construct a computer simulation model that would accurate portray the time course for a series of individuals to develop cognitive impairment and to progress to major neurocognitive disorder.MethodsWe built a computer simulation model that incorporated the role of exercise, gen

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Tsai, Alice W., Colleen F. McNeil, Joshua R. Leeman, et al. "Novel Ranking System for Identifying Efficacious Anti-Influenza Virus PB2 Inhibitors." Antimicrobial Agents and Chemotherapy 59, no. 10 (2015): 6007–16. http://dx.doi.org/10.1128/aac.00781-15.

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ABSTRACTThrough antigenic drift and shifts, influenza virus infections continue to be an annual cause of morbidity in healthy populations and of death among elderly and at-risk patients. The emergence of highly pathogenic avian influenza viruses such as H5N1 and H7N9 and the rapid spread of the swine-origin H1N1 influenza virus in 2009 demonstrate the continued need for effective therapeutic agents for influenza. While several neuraminidase inhibitors have been developed for the treatment of influenza virus infections, these have shown a limited window for treatment initiation, and resistant v

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Bonasoni, P., P. Laj, A. Marinoni, et al. "Atmospheric Brown Clouds in the Himalayas: first two years of continuous observations at the Nepal-Climate Observatory at Pyramid (5079 m)." Atmospheric Chemistry and Physics Discussions 10, no. 2 (2010): 4823–85. http://dx.doi.org/10.5194/acpd-10-4823-2010.

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Abstract. South Asia is strongly influenced by the so-called Atmospheric Brown Cloud (ABC), a wide polluted layer extending from the Indian Ocean to the Himalayas during the winter and pre-monsoon seasons (November to April). This thick, grey-brown haze blanket substantially interacts with the incoming solar radiation, causing a cooling of the Earth's surface and a warming of the atmosphere, thus influencing the monsoon system and climate. In this area, the Himalayan region, particularly sensitive to climate change, offers a unique opportunity to detect global change processes and to analyse t

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Blum, Irene H., Patricia S. Koskinen, Nancy Tennant, E. Marie Parker, Mary Straub, and Christine Curry. "Using Audiotaped Books to Extend Classroom Literacy Instruction into the Homes of Second-Language Learners." Journal of Reading Behavior 27, no. 4 (1995): 535–63. http://dx.doi.org/10.1080/10862969509547898.

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The purpose of this study was to investigate whether home-based repeated reading with an audio model is a significant supplement to the literacy instructional program of second-language learners. It was hypothesized that beginning first-grade readers who spoke English as a second language would benefit from having daily access to repeated reading in their home environment. To provide this access, books that had been shared in school were given to students for daily home use. After home rereading routines were established, students were then given a tape recorder and audiotapes to accompany the

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Dutta, Noton K., Michael L. Pinn, and Petros C. Karakousis. "Reduced Emergence of Isoniazid Resistance with Concurrent Use of Thioridazine against Acute Murine Tuberculosis." Antimicrobial Agents and Chemotherapy 58, no. 7 (2014): 4048–53. http://dx.doi.org/10.1128/aac.02981-14.

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ABSTRACTThe repurposing of existing drugs is being pursued as a means by which to accelerate the development of novel regimens for the treatment of drug-susceptible and drug-resistant tuberculosis (TB). In the current study, we assessed the activity of the antipsychotic drug thioridazine (TRZ) in combination with the standard regimen in a well-validated murine TB model. Single-dose and steady-state pharmacokinetic studies were performed in BALB/c mice to establish human-equivalent doses of TRZ. To determine the bactericidal activity of TRZ against TB in BALB/c mice, three separate studies were

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Barni, S., Galligioni, S. Gori, et al. "Fulvestrant: a new opportunity in advanced breast cancer (ABC)." European Journal of Cancer Supplements 4, no. 2 (2006): 170. http://dx.doi.org/10.1016/s1359-6349(06)80438-6.

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Sachin, Kumar, Prasad K. Krishna, and S. Aithal P. "Tech-Business Analytics – a Review-based New Model to Improve the Performances of Various Industry Sectors." International Journal of Applied Engineering and Management Letters (IJAEML) 7, no. 1 (2023): 67–91. https://doi.org/10.5281/zenodo.7657622.

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<strong>Purpose: </strong><em>Integration of ICCT underlying technologies and big data technology to develop a new kind of Business analytics that can be used to solve semi-structured and unstructured problems of various industry sectors i.e., primary, secondary, tertiary, and quaternary industry sectors. The new study is known as Tech-business analytics (TBA). The goal of this study is to better understand the idea of TBA and how it influences a company's innovation outcomes.</em> <strong>Design/Methodology/Approach:</strong> <em>The originality of business analytics products/services in

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Ridlo, Wildani, Arina Nur Sofiana, and Shaleh Shaleh. "Studi Komparasi Model Activity-Based Costing (ABC) dengan Model Tradisional dalam Estimasi Biaya Satuan Pendidikan." Mauriduna: Journal of Islamic Studies 5, no. 2 (2024): 351–66. https://doi.org/10.37274/mauriduna.v5i2.1196.

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Kompleksitas pengelolaan keuangan lembaga pendidikan memunculkan kebutuhan akan model akuntansi yang lebih akurat dan responsif. Dalam konteks ini, model Activity-Based Costing (ABC) menawarkan pendekatan inovatif dalam mengidentifikasi dan menganalisis struktur biaya pendidikan. Melalui kajian literatur dan analisis data sekunder, studi mengeksplorasi keunggulan model ABC dibandingkan model akuntansi tradisional. Temuan mengungkapkan kemampuan ABC dalam menelusuri biaya berdasarkan aktivitas spesifik, menghasilkan pemetaan keuangan yang lebih presisi dan mengatasi distorsi biaya yang inherent

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LI, Guisheng. "ABC model and floral evolution." Chinese Science Bulletin 48, no. 24 (2003): 2651. http://dx.doi.org/10.1360/03wc0234.

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Li, Guisheng, Zheng Meng, Hongzhi Kong, Zhiduan Chen, and Anming Lu. "ABC model and floral evolution." Chinese Science Bulletin 48, no. 24 (2003): 2651–57. http://dx.doi.org/10.1007/bf02901752.

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Zhu, Jiangshan, and Ross Noel Bannister. "The Hydro-ABC model (Version 2.0): a simplified convective-scale model with moist dynamics." Geoscientific Model Development 16, no. 21 (2023): 6067–85. http://dx.doi.org/10.5194/gmd-16-6067-2023.

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Abstract. The prediction of convection (in terms of position, timing, and strength) is important to achieve for high-resolution weather forecasting. This problem requires not only good convective-scale models, but also data assimilation systems that give initial conditions which neither improperly hinder nor improperly hasten convection in the ensuing forecasts. Solving this problem is difficult and expensive using operational-scale numerical weather prediction systems, and so a simplified model of convective-scale flow is under development (called the “ABC model”). This paper extends the exis

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Zou, Jing, Peizhe Xin, Zhihong Xiao, et al. "Trusted Access Authentication Technology for Large-Scale Heterogeneous Terminals in a Vehicle Charging Network System." Electronics 12, no. 8 (2023): 1882. http://dx.doi.org/10.3390/electronics12081882.

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A vehicle charging network system has to access large-scale heterogeneous terminals to collect charging pile status information, which may also give malicious terminals an opportunity to access. Though some general access authentication solutions aimed at only allowing trusted terminals have been proposed, they are difficult to work with in a vehicle charging network system. First, among various heterogeneous terminals with significant differences in computing capabilities, there are inevitably terminals that cannot support computations required for cryptography-based access authentication sch

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Toni, Tina, David Welch, Natalja Strelkowa, Andreas Ipsen, and Michael P. H. Stumpf. "Approximate Bayesian computation scheme for parameter inference and model selection in dynamical systems." Journal of The Royal Society Interface 6, no. 31 (2008): 187–202. http://dx.doi.org/10.1098/rsif.2008.0172.

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Approximate Bayesian computation (ABC) methods can be used to evaluate posterior distributions without having to calculate likelihoods. In this paper, we discuss and apply an ABC method based on sequential Monte Carlo (SMC) to estimate parameters of dynamical models. We show that ABC SMC provides information about the inferability of parameters and model sensitivity to changes in parameters, and tends to perform better than other ABC approaches. The algorithm is applied to several well-known biological systems, for which parameters and their credible intervals are inferred. Moreover, we develo

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González, Gloria M., Efrén Robledo, Elvira Garza-González, Mariana Elizondo, and J. Gerardo González. "Efficacy of Albaconazole against Candida albicans in a Vaginitis Model." Antimicrobial Agents and Chemotherapy 53, no. 10 (2009): 4540–41. http://dx.doi.org/10.1128/aac.00565-09.

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ABSTRACT The efficacy of albaconazole (ABC) was evaluated using a murine model of vaginal Candida albicans infection. Both ABC and fluconazole (FLC) were effective in reducing the fungal load from vaginas of infected mice; however, ABC demonstrated encouraging activities against an FLC-resistant strain, with trends toward superiority over FLC in some treatment groups.

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Hashim, Jamalludin Helmi. "Activity-based costing (ABC) Model for Public Higher Education Institutions (PHEI) : A guide for a Model development." INTERNATIONAL JOURNAL OF MANAGEMENT & INFORMATION TECHNOLOGY 7, no. 3 (2013): 1089–100. http://dx.doi.org/10.24297/ijmit.v7i3.696.

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 The purpose of this study is to develop the Activity-based costing (ABC) model for Bachelor of Accountancy (BACC) program in University of Excellence (UoE) Malaysia. A case study approach using the professional software, ABM-SAS, and the actual expenses figure for BACC for the year 20XX were used to develop the ABC model in this study. The finding showed that the cost computed using the ABC Model is lower as compared to the cost from the traditional (current) method, i.e. RM 8,678.54 and RM 10,509.99, respectively. The differences amounted RM 1,830.55 in cost calculated by these two sys

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