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Journal articles on the topic 'Abguss'

Author: Grafiati

Published: 25 July 2024

Last updated: 31 July 2025

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1

Jungenitz, Tassilo, Marcel Beining, Tijana Radic, et al. "Structural homo- and heterosynaptic plasticity in mature and adult newborn rat hippocampal granule cells." Proceedings of the National Academy of Sciences 115, no. 20 (2018): E4670—E4679. http://dx.doi.org/10.1073/pnas.1801889115.

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Adult newborn hippocampal granule cells (abGCs) contribute to spatial learning and memory. abGCs are thought to play a specific role in pattern separation, distinct from developmentally born mature GCs (mGCs). Here we examine at which exact cell age abGCs are synaptically integrated into the adult network and which forms of synaptic plasticity are expressed in abGCs and mGCs. We used virus-mediated labeling of abGCs and mGCs to analyze changes in spine morphology as an indicator of plasticity in rats in vivo. High-frequency stimulation of the medial perforant path induced long-term potentiatio

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Luna, Victor M., Christoph Anacker, Nesha S. Burghardt, et al. "Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus." Science 364, no. 6440 (2019): 578–83. http://dx.doi.org/10.1126/science.aat8789.

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Young adult-born granule cells (abGCs) in the dentate gyrus (DG) have a profound impact on cognition and mood. However, it remains unclear how abGCs distinctively contribute to local DG information processing. We found that the actions of abGCs in the DG depend on the origin of incoming afferents. In response to lateral entorhinal cortex (LEC) inputs, abGCs exert monosynaptic inhibition of mature granule cells (mGCs) through group II metabotropic glutamate receptors. By contrast, in response to medial entorhinal cortex (MEC) inputs, abGCs directly excite mGCs throughN-methyl-d-aspartate recept

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3

Heumer, Wolfgang. "„Elektra“ verzichtet auf Abgase." VDI nachrichten 76, no. 03 (2022): 10. http://dx.doi.org/10.51202/0042-1758-2022-03-10.

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4

Märzhäuser, Helene. "Abgase, die neuen Rohstoffe." Nachrichten aus der Chemie 64, no. 11 (2016): 1077–78. http://dx.doi.org/10.1002/nadc.20164056633.

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5

Corrêa, Dinalva da Silva, and Denise Simões Simões Rodrigues. "Memória política do Pará na voz poética de Abguar Bastos: romance Safra, um eco da resistência na Amazônia." Boitatá 14, no. 27 (2019): 145. http://dx.doi.org/10.5433/boitata.2019v14.e37997.

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Este artigo trata de uma pesquisa de Dissertação em andamento. O objetivo é demonstrar comoa influência das posições políticas de Abguar Bastos está presente no romance Safra (1937), pertencente à Série Os dramas da Amazônia. Tem como questões centrais: 1. Abordar de forma breve aspectos da vida e obra de Abguar Bastos; 2. Apresentar a memória política do escritor e por fim, na última seção discutir sobre o romance “Safra”, demonstrando a influência política na obra em relação à educação. Dessa forma, este artigo se caracteriza do ponto de vista metodológico como uma pesquisa qualitativa do ti

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Nusrullah, Muhammad, Muhammad Younus, and Yasir Nasir. "Relationship between Arterial and Venous Blood Gases in Patients Presenting with Chronic Obstructive Pulmonary Disease." Annals of King Edward Medical University 24, no. 1 (2018): 684–88. http://dx.doi.org/10.21649/akemu.v24i1.2343.

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Arterial blood gas analysis is an important test for determining acid base balance of the body. Chronic obstructive pulmonary disease is characterized by chronic airflow limitation which is not fully reversible and it can lead to respiratory failure. Objective: To determine the correlation between arterial and venous blood gases in patients presenting with chronic obstructive pulmonary disease. Material and Methods: This cross sectional study was conducted at Department of Chest Medicine, Mayo Hospital, Lahore, Pakistan. After meeting the inclusion criteria, 100 patients were enrolled. Informe

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Wu, An, Bin Yu, Qiyu Chen, et al. "Context-dependent plasticity of adult-born neurons regulated by cortical feedback." Science Advances 6, no. 42 (2020): eabc8319. http://dx.doi.org/10.1126/sciadv.abc8319.

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In a complex and dynamic environment, the brain flexibly adjusts its circuits to preferentially process behaviorally relevant information. Here, we investigated how the olfactory bulb copes with this demand by examining the plasticity of adult-born granule cells (abGCs). We found that learning of olfactory discrimination elevates odor responses of young abGCs and increases their apical dendritic spines. This plasticity did not occur in abGCs during passive odor experience nor in resident granule cells (rGCs) during learning. Furthermore, we found that feedback projections from the piriform cor

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Hofman, Jean-Marc. "Une collection de plâtres méconnue. Les moulages de sculpture du Moyen Âge français de la Villa Médicis." Studiolo 13, no. 1 (2016): 184–96. http://dx.doi.org/10.3406/studi.2016.1037.

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Eine Sammlung von missverstandenen Gipsabgüssen. Die Abgüsse von Skulpturen des französischen Mittelalters der Villa Im Jahr 1918 bietet Albert Besnard der Villa Medici eine patriotische Propaganda und künstlerische Ausstellung von Gipsabgüssen von mittelalterlichen französischen Skulpturen. Mit dieser Veranstaltung wollte man den Italienern den Kapitalverlust auf französischem Boden beweisen. Dies wurde mit zwei Veranstaltungen, wo der künstlerische und architektonische Reichtum hervorgehoben wurde, unterstrichen. Die Abgüsse mittelalterlichen Skulpturen, benannt “ Musée de Sculpture“ und heu

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9

Krijgsman, Arco, Arjen de Jong, and Rick Breunesse. "Zylinderabschaltung mit Nachexpansion der Abgase." MTZ - Motortechnische Zeitschrift 81, no. 2 (2020): 60–65. http://dx.doi.org/10.1007/s35146-019-0168-1.

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10

Kohse-Höinghaus, Katharina. "Chemische Konzepte für saubere Abgase." Nachrichten aus der Chemie 57, no. 12 (2009): 1176–81. http://dx.doi.org/10.1002/nadc.200969051.

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11

Davis, J. Q., T. McLaughlin, and V. Bennett. "Ankyrin-binding proteins related to nervous system cell adhesion molecules: candidates to provide transmembrane and intercellular connections in adult brain." Journal of Cell Biology 121, no. 1 (1993): 121–33. http://dx.doi.org/10.1083/jcb.121.1.121.

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A major class of ankyrin-binding glycoproteins have been identified in adult rat brain of 186, 155, and 140 kD that are alternatively spliced products of the same pre-mRNA. Characterization of cDNAs demonstrated that ankyrin-binding glycoproteins (ABGPs) share 72% amino acid sequence identity with chicken neurofascin, a membrane-spanning neural cell adhesion molecule in the Ig super-family expressed in embryonic brain. ABGP polypeptides have the following features consistent with a role as ankyrin-binding proteins in vitro and in vivo: (a) ABGPs and ankyrin associate as pure proteins in a 1:1

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12

Rode, Jörg. "Rewe Nord nutzt Wasserstoff-Lkw." Lebensmittel Zeitung 75, no. 36 (2023): 33. http://dx.doi.org/10.51202/0947-7527-2023-36-033.

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13

König, Klaus W. "Holzpellet-Feuer ohne Flamme reinigt das Abgas." Technische Sicherheit 14, no. 05-06 (2024): 28–33. http://dx.doi.org/10.37544/2191-0073-2024-05-06-28.

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Dass Abwärme und ein Teil der Schadstoffe aus dem Abgas zurückgeholt werden können, zeichnet die Brennwerttechnik eines Öl- und Gas-Heizkessels aus. Sie galt lange bei Holzbrennstoffen als nicht machbar. Zur Reinhaltung der Luft gibt es nun eine zusätzliche Option, wenn die Verbrennung ohne Flamme geschieht und Feinstaub aus dem Abgas erst gar nicht entsteht.

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König, Klaus W. "Holzpellet-Feuer ohne Flamme reinigt das Abgas." HLH 76, no. 04 (2025): 32–35. https://doi.org/10.37544/1436-5103-2025-04-32.

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Dass Abwärme und ein Teil der Schadstoffe aus dem Abgas zurückgeholt werden können, zeichnet die Brennwerttechnik eines Öl- und Gas-Heizkessels aus. Bei Holzbrennstoffen galt dies lange als nicht machbar. Zur Reinhaltung der Luft gibt es nun eine zusätzliche Option: Mit einer Verbrennung ohne Flamme, so dass Feinstaub im Abgas erst gar nicht entsteht.

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15

Bauer, Uta, Thomas Stein, and Victoria Langer. "Mobilität in klimaneutralen Stadtquartieren – elektrisch, multimodal und vernetzt." Ökologisches Wirtschaften - Fachzeitschrift 33, no. 3 (2019): 22. http://dx.doi.org/10.14512/oew340322.

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Lärm, Abgase und Unfallgefahr sind neben der Flächendominanz parkender Pkw zentrale Probleme für die derzeitige Stadt- und Verkehrsentwicklung. Das Projekt „City2Share“ gibt Anhaltspunkte für ökologische Alternativen.

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Muse, Dani. "Kosteneffizient Abgase in der Halbleiterindustrie reinigen." UmweltMagazin 49, no. 03 (2019): 46–47. http://dx.doi.org/10.37544/0173-363x-2019-03-46.

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Komplexe Produktionen in der Industrie erfordern oft eine angepasste Abgasreinigung. Diese Anlagen sollen gesetzlichen Regelungen erfüllen, leistungsfähig sein und wenig kosten. Um diese zu verwirklichen, sind die Technologien auf die jeweilige Anwendung abzustimmen. Wichtig ist eine ergebnisoffene Herangehensweise.

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17

ALBUQUERQUE, Gerson Rodrigues, and Raquel Alves ISHII. "A Amazônia acreana de Abguar Bastos." Muiraquitã - Revista de Letras e Humanidades 2, no. 1 (2013): 116–36. http://dx.doi.org/10.29327/210932.2.1-6.

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18

Krehl, Detlef. "Ladungswechsel Austausch des Abgases durch Frischgas." MTZ - Motortechnische Zeitschrift 75, no. 7 (2014): 6–7. http://dx.doi.org/10.1007/s35146-014-0377-6.

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19

Longkumer, Toshisangba, Sunil Parthasarathy, Sujana Ghanta Vemuri, and Dayananda Siddavattam. "OxyR-dependent expression of a novel glutathione S-transferase (Abgst01) gene in Acinetobacter baumannii DS002 and its role in biotransformation of organophosphate insecticides." Microbiology 160, no. 1 (2014): 102–12. http://dx.doi.org/10.1099/mic.0.070664-0.

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While screening a genomic library of Acinetobacter baumannii DS002 isolated from organophosphate (OP)-polluted soils, nine ORFs were identified coding for glutathione S-transferase (GST)-like proteins. These GSTs (AbGST01–AbGST09) are phylogenetically related to a number of well-characterized GST classes found in taxonomically diverse groups of organisms. Interestingly, expression of Abgst01 (GenBank accession no. KF151191) was upregulated when the bacterium was grown in the presence of an OP insecticide, methyl parathion (MeP). The gene product, AbGST01, dealkylated MeP to desMeP. An OxyR-bin

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20

Gores, Stefan. "Aus Abgas wird Strom." UmweltMagazin 50, no. 01-02 (2020): 12–14. http://dx.doi.org/10.37544/0173-363x-2020-01-02-12.

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In einer Industrielackierung in Geilenkirchen wird im Februar aus einem Umweltproblem ein Paradebeispiel ökologischer Energieerzeugung. Im Hintergrund steht ein intelligentes Konzept eines Aachener Anlagenbauers: In einem ersten Schritt werden Lösemittel aufkonzentriert, um dann in kleinen Gasturbinen mitverbrannt zu werden.

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21

Holz, Stephan. "Mit modernem Flottenmanagement den Kraftstoffverbrauch senken." Logistik für Unternehmen 33, no. 07-08 (2019): 36–37. http://dx.doi.org/10.37544/0930-7834-2019-07-08-36.

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Effizienzsteigerung | Fuhrparkmanager können mit intelligenter Software ihre Klimabilanz positiv beeinflussen und Kosten sparen. Flottenmanagement-Software kann helfen, den Kraftstoffverbrauch nachweislich zu reduzieren und die Leerlaufzeiten der Fahrzeuge zu senken. Das Ergebnis: Weniger schädliche Abgase gelangen in die Luft.

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22

Füeßl, Hermann S. "Fördern Abgase Asthma bei Kids doch nicht?" Pneumo News 7, no. 4 (2015): 11–12. http://dx.doi.org/10.1007/s15033-015-0180-1.

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23

Anderson, Sam. "ABGs." AJN, American Journal of Nursing 90, no. 8 (1990): 42–46. http://dx.doi.org/10.1097/00000446-199008000-00020.

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24

Luhmann, Hans-Jochen. "Europas Staatsversagen im Abgas-Fall." GWP – Gesellschaft. Wirtschaft. Politik 66, no. 2 (2017): 173–80. http://dx.doi.org/10.3224/gwp.v66i2.01.

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Stamatelos, Anastassios M., Grigorios C. Koltsakis, and Ioannis P. Kandylas. "Computergestützter Entwurf von Abgas-Nachbehandlungskonzepten." MTZ - Motortechnische Zeitschrift 60, no. 2 (1999): 116–24. http://dx.doi.org/10.1007/bf03226495.

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Stamatelos, Anastassios M., Grigorios C. Koltsakis, and Ioannis P. Kandylas. "Computergestützter Entwurf von Abgas-Nachbehandlungskonzepten." MTZ - Motortechnische Zeitschrift 60, no. 3 (1999): 194–204. http://dx.doi.org/10.1007/bf03226502.

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Koop, Dittmar. "Abwärme aus dem Abgas holen." HLH 74, no. 05 (2023): 20–22. http://dx.doi.org/10.37544/1436-5103-2023-05-20.

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Seit der unsicheren Versorgungssituation im vergangenen Herbst und Winter gewinnen ressourcenschonende Verfahren zur Energiegewinnung an Popularität – so auch die Nutzung von Wärme aus Abgas. Die dafür nötigen Abgaswärmetauscher zählen zu den etablierten Technologien, werden bislang aber dennoch wenig eingesetzt. Umso erstaunlicher ist dies, da sie sich recht schnell bezahlt machen.

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28

Reis, Marcos Valério. "TERRA DE ICAMIABA DE ABGUAR BASTOS E A FUNDAÇÃO DO ROMANCE AMAZÔNICO." Projeto História : Revista do Programa de Estudos Pós-Graduados de História 73 (May 1, 2022): 128–53. http://dx.doi.org/10.23925/2176-2767.2022v73p128-153.

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Este artigo objetiva estabelecer um olhar atento a literatura do escritor e intelectual amazônida, Abguar Bastos e sua imersão literária na composição do Modernismo Amazônico por meio de sua obra Terra de Icamiaba (1931), que pode ser entendida como a materialidade de sua proposta para o Modernismo brasileiro a partir da Amazônia.

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Cho, Shin-Gyu, Myungchul Song, Kimleng Chuon, Jin-gon Shim, Seanghun Meas, and Kwang-Hwan Jung. "Heliorhodopsin binds and regulates glutamine synthetase activity." PLOS Biology 20, no. 10 (2022): e3001817. http://dx.doi.org/10.1371/journal.pbio.3001817.

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Photoreceptors are light-sensitive proteins found in various organisms that respond to light and relay signals into the cells. Heliorhodopsin, a retinal-binding membrane protein, has been recently discovered, however its function remains unknown. Herein, we investigated the relationship between Actinobacteria bacterium IMCC26103 heliorhodopsin (AbHeR) and an adjacent glutamine synthetase (AbGS) in the same operon. We demonstrate that AbHeR binds to AbGS and regulates AbGS activity. More specifically, the dissociation constant (Kd) value of the binding between AbHeR and AbGS is 6.06 μM. Moreove

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Horne, Claydell, and David Derrico. "Mastering ABGs." American Journal of Nursing 99, no. 8 (1999): 26–32. http://dx.doi.org/10.1097/00000446-199908000-00035.

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Pruitt, Bill. "Interpreting ABGs." Nursing 40, no. 7 (2010): 31–35. http://dx.doi.org/10.1097/01.nurse.0000383447.25412.d6.

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&NA;. "Interpreting ABGs." Nursing 40, no. 7 (2010): 35–36. http://dx.doi.org/10.1097/01.nurse.0000383448.02541.1e.

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33

"Abgase." Nachrichten aus Chemie und Technik 2, no. 24 (2010): 244–45. http://dx.doi.org/10.1002/nadc.19540022404.

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"Ungesunde Abgase." Allergo Journal 13, no. 5 (2004): 292. http://dx.doi.org/10.1007/bf03361380.

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"Beseitigung nitroser Abgase." Nachrichten aus Chemie und Technik 9, no. 23 (2010): 362. http://dx.doi.org/10.1002/nadc.19610092308.

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"Norwegische Petroglyphen-Abgüsse." Nachrichten aus Chemie und Technik 12, no. 15 (2010): 310. http://dx.doi.org/10.1002/nadc.19640121510.

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Laham, Blake J., Isha R. Gore, Casey J. Brown, and Elizabeth Gould. "Adult-born granule cells modulate CA2 network activity during retrieval of developmental memories of the mother." eLife 12 (June 4, 2024). http://dx.doi.org/10.7554/elife.90600.3.

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Adult-born granule cells (abGCs) project to the CA2 region of the hippocampus, but it remains unknown how this circuit affects behavioral function. Here, we show that abGC input to the CA2 of adult mice is involved in the retrieval of remote developmental memories of the mother. Ablation of abGCs impaired the ability to discriminate between a caregiving mother and a novel mother, and this ability returned after abGCs were regenerated. Chemogenetic inhibition of projections from abGCs to the CA2 also temporarily prevented the retrieval of remote mother memories. These findings were observed whe

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Brunner, János, Máté Neubrandt, Susan Van-Weert, et al. "Adult-born granule cells mature through two functionally distinct states." eLife 3 (July 24, 2014). http://dx.doi.org/10.7554/elife.03104.

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Adult-born granule cells (ABGCs) are involved in certain forms of hippocampus-dependent learning and memory. It has been proposed that young but functionally integrated ABGCs (4-weeks-old) specifically contribute to pattern separation functions of the dentate gyrus due to their heightened excitability, whereas old ABGCs (>8 weeks old) lose these capabilities. Measuring multiple cellular and integrative characteristics of 3- 10-week-old individual ABGCs, we show that ABGCs consist of two functionally distinguishable populations showing highly distinct input integration properties (one group

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"Strengere Vorgaben für Abgase." ENTSORGA-Magazin 40, no. 1 (2021): 58. http://dx.doi.org/10.51202/0933-3754-2021-1-058-2.

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40

"Abgase machen Pollen aggressiver." DMW - Deutsche Medizinische Wochenschrift 140, no. 18 (2015): 1333. http://dx.doi.org/10.1055/s-0041-106214.

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"Abgase, Allergien und Antioxidanzien." Allergo Journal 16, no. 2 (2007): 94. http://dx.doi.org/10.1007/bf03371937.

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"Katalytische Nachverbrennung industrieller Abgase." Nachrichten aus Chemie und Technik 12, no. 15 (2010): 311. http://dx.doi.org/10.1002/nadc.19640121511.

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Lybrand, Zane R., Sonal Goswami, Jingfei Zhu, et al. "A critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy." Nature Communications 12, no. 1 (2021). http://dx.doi.org/10.1038/s41467-021-21649-8.

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AbstractIn the mammalian hippocampus, adult-born granule cells (abGCs) contribute to the function of the dentate gyrus (DG). Disruption of the DG circuitry causes spontaneous recurrent seizures (SRS), which can lead to epilepsy. Although abGCs contribute to local inhibitory feedback circuitry, whether they are involved in epileptogenesis remains elusive. Here, we identify a critical window of activity associated with the aberrant maturation of abGCs characterized by abnormal dendrite morphology, ectopic migration, and SRS. Importantly, in a mouse model of temporal lobe epilepsy, silencing aber

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Naderi, Ghazal, Mahla Asadian, Arash Seifi, et al. "Dissemination of the Acinetobacter baumannii isolates belonging to global clone 2 containing AbGRI resistance islands in a referral hospital." Microbiology Spectrum, August 28, 2023. http://dx.doi.org/10.1128/spectrum.05373-22.

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ABSTRACT Acinetobacter baumannii strains belonging to global clone 2 (GC2) contain resistance islands (AbGRIs), which are composed of genes conferring resistance to older and newer antibiotics. Here, to locate these genes in AbGRIs, the GC2 strains from Tehran, Iran were examined. Among the 170 A . baumannii , 90 isolates were identified as GC2. Of the genes that confer resistance to older antibiotics, tetA(B ), tetR(B) (tetracyclines), strA , and strB (aminoglycosides) were located in AbGRI1 of 65 GC2 isolates (72.2%). Of the other aminoglycosides, the aphA1b was located in AbGRI2-12b (63.6%)

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Wallace, Jenelle, Julia Lord, Lasse Dissing-Olesen, Beth Stevens, and Venkatesh N. Murthy. "Microglial depletion disrupts normal functional development of adult-born neurons in the olfactory bulb." eLife 9 (March 9, 2020). http://dx.doi.org/10.7554/elife.50531.

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Microglia play key roles in regulating synapse development and refinement in the developing brain, but it is unknown whether they are similarly involved during adult neurogenesis. By transiently depleting microglia from the healthy adult mouse brain, we show that microglia are necessary for the normal functional development of adult-born granule cells (abGCs) in the olfactory bulb. Microglial depletion reduces the odor responses of developing, but not preexisting GCs in vivo in both awake and anesthetized mice. Microglia preferentially target their motile processes to interact with mushroom sp

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Naderi, Ghazal, Mahla Asadian, Pegah Afarinesh Khaki, Mohammadreza Salehi, Alireza Abdollahi, and Masoumeh Douraghi. "Occurrence of Acinetobacter baumannii genomic resistance islands (AbGRIs) in Acinetobacter baumannii strains belonging to global clone 2 obtained from COVID-19 patients." BMC Microbiology 23, no. 1 (2023). http://dx.doi.org/10.1186/s12866-023-02961-3.

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Abstract Aim The Acinetobacter baumannii genomic resistance islands (AbGRIs), which were characterized in the genome of the global clone 2 (GC2) A. baumannii contain resistance genes. Here, we aimed to determine the occurrence of AbGRIs in GC2 A. baumannii obtained from COVID-19 patients in a referral hospital in Tehran, Iran. Methods A total of 19 carbapenem-resistant A. baumannii (CRAB) isolates belonging to GC2 and sequence type 2 (ST2), including 17 from COVID-19 patients and two from the devices used in the ICU that the COVID-19 patients were admitted, were examined in this study. Antibio

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Ji, Qi, Yang Yang, Yun Xiong, et al. "Blockade of adenosine A2A receptors reverses early spatial memory defects in the APP/PS1 mouse model of Alzheimer’s disease by promoting synaptic plasticity of adult-born granule cells." Alzheimer's Research & Therapy 15, no. 1 (2023). http://dx.doi.org/10.1186/s13195-023-01337-z.

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Abstract Background The over-activation of adenosine A2A receptors (A2AR) is closely implicated in cognitive impairments of Alzheimer's disease (AD). Growing evidence shows that A2AR blockade possesses neuroprotective effects on AD. Spatial navigation impairment is an early manifestation of cognitive deficits in AD. However, whether A2AR blockade can prevent early impairments in spatial cognitive function and the underlying mechanism is still unclear. Methods A transgenic APP/PS1 mouse model of AD amyloidosis was used in this study. Behavioral tests were conducted to observe the protective eff

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Reshef, Ronen, Elena Kudryavitskaya, Haran Shani-Narkiss, et al. "The role of microglia and their CX3CR1 signaling in adult neurogenesis in the olfactory bulb." eLife 6 (December 18, 2017). http://dx.doi.org/10.7554/elife.30809.

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Microglia play important roles in perinatal neuro- and synapto-genesis. To test the role of microglia in these processes during adulthood, we examined the effects of microglia depletion, via treatment of mice with the CSF-1 receptor antagonist PLX5622, and abrogated neuronal-microglial communication in CX3C receptor-1 deficient (Cx3cr1−/−) mice. Microglia depletion significantly lowered spine density in young (developing) but not mature adult-born-granule-cells (abGCs) in the olfactory bulb. Two-photon time-lapse imaging indicated that microglia depletion reduced spine formation and eliminatio

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Sparks, F. T., Z. Liao, W. Li, A. Grosmark, I. Soltesz, and A. Losonczy. "Hippocampal adult-born granule cells drive network activity in a mouse model of chronic temporal lobe epilepsy." Nature Communications 11, no. 1 (2020). http://dx.doi.org/10.1038/s41467-020-19969-2.

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AbstractTemporal lobe epilepsy (TLE) is characterized by recurrent seizures driven by synchronous neuronal activity. The reorganization of the dentate gyrus (DG) in TLE may create pathological conduction pathways for synchronous discharges in the temporal lobe, though critical microcircuit-level detail is missing from this pathophysiological intuition. In particular, the relative contribution of adult-born (abGC) and mature (mGC) granule cells to epileptiform network events remains unknown. We assess dynamics of abGCs and mGCs during interictal epileptiform discharges (IEDs) in mice with TLE a

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Kennedy, William M., Jose Carlos Gonzalez, Haeun Lee, Jacques I. Wadiche, and Linda Overstreet-Wadiche. "T-type Ca²⁺channels mediate a critical period of plasticity in adult-born granule cells." Journal of Neuroscience, February 27, 2024, e1503232024. http://dx.doi.org/10.1523/jneurosci.1503-23.2024.

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Abstract:

Adult-born granule cells (abGCs) exhibit a transient period of elevated synaptic plasticity that plays an important role in hippocampal function. Various mechanisms have been implicated in this critical period for enhanced plasticity, including minimal GABAergic inhibition and high intrinsic excitability conferred by T-type Ca2+channels. Here we assess the contribution of synaptic inhibition and intrinsic excitability to long-term potentiation (LTP) in abGCs of adult male and female mice using perforated patch recordings. We show that the timing of critical-period plasticity is unaffected by i

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