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Journal articles on the topic 'Abortifacient'

Author: Grafiati

Published: 3 June 2025

Last updated: 22 June 2025

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1

de Oddone, Nelly Krayacich, Michele G. Shedlin, Michael Welsh, Malcolm Potts, and Paul Feldblum. "Paraguayan pharmacies and the sale of pseudo-abortifacients." Journal of Biosocial Science 23, no. 2 (1991): 201–9. http://dx.doi.org/10.1017/s0021932000019210.

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SummaryThis study was conducted in 1985 in Asunción, Paraguay, 6 years after the closure of the state supported family planning services. Data from national surveys in 1977 and 1987 permit a comparison of sources of contraceptive supplies before and after the elimination of government support for family planning. The purchase of pseudo-abortifacients from private pharmacies was used as an indication of induced abortion. After the loss of government clinics, it is suggested that some women turned to pharmacists to obtain pseudo-abortifacients when faced with unwanted pregnancy. There is an indication of increased pseudo-abortifacient use, particularly among unmarried women and those from poorer neighbourhoods.

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2

Mbaya, Y.P, D. Yahi, and A. William. "Abortifacient Effects of Aqueous Leaf Extract of Annona senegalensis Pers in Albino Rats." Continental J. Applied Sciences 14, no. 2 (2019): 68–77. https://doi.org/10.5281/zenodo.3524825.

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The use of abortifacient plants is commonly practiced among the natives in Nigeria as an aborting agent of pregnancy. Abortifacient substances are either chemical or physical capable of inducing abortion. One of the plants that is being used is <em>Annona senegalensis</em>, although it is primarily used as food. Its abortifacient activity is not scientifically validated. This study investigated the abortifacient activity of the leaf extract. The aqueous leaf extract of <em>Annona senegalensis</em> pers was screened for abortifacient activity in thirty (30) female albino rats at the doses of 100, 200, 300 and 400 mg/kg daily. The oral administration of the extract to female albino rats for three weeks of the gestation period resulted in reduced individual implantation sites, live fetuses, postimplantation loss and progressive decrease in serum progesterone concentration in a dose dependent manner. <em>Annona senegalensis</em> leaf therefore, has significant abortifacient activity.  

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3

Zordo, Silvia De. "The biomedicalisation of illegal abortion: the double life of misoprostol in Brazil." História, Ciências, Saúde-Manguinhos 23, no. 1 (2016): 19–36. http://dx.doi.org/10.1590/s0104-59702016000100003.

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Abstract This paper examines the double life of misoprostol in Brazil, where it is illegally used by women as an abortifacient and legally used in obstetric hospital wards. Based on my doctoral and post-doctoral anthropological research on contraception and abortion in Salvador, Bahia, this paper initially traces the “conversion” of misoprostol from a drug to treat ulcers to a self-administered abortifacient in Latin America, and its later conversion to aneclectic global obstetric tool. It then shows how, while reducing maternal mortality, its use as an illegal abortifacient has reinforced the double reproductive citizenship regime existing in countries with restrictive abortion laws and poor post-abortion care services, where poor women using it illegally are stigmatised, discriminated against and exposed to potentially severe health risks.

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4

Austriaco, Nicanor Pier Giorgio. "Is Plan B an Abortifacient?" National Catholic Bioethics Quarterly 7, no. 4 (2007): 703–7. http://dx.doi.org/10.5840/ncbq2007746.

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5

Wright, Steve. "Abortifacient drugs: ethico-legal issues." Nursing Standard 5, no. 24 (1991): 36–37. http://dx.doi.org/10.7748/ns.5.24.36.s40.

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6

Poolsawat, S. S., and C. A. Huerta. "Acetaminophen: Abortifacient and embryocidal action." Proceedings, annual meeting, Electron Microscopy Society of America 44 (August 1986): 130–31. http://dx.doi.org/10.1017/s0424820100142293.

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Introduction. Chemical toxicity in the U.S. affects approximately 40% of the nation's 80 million workers who are exposed to toxic chemicals on a full or part-time bases. In 1980, about 40% of this workforce was comprised of women of childbearing ages. Considering such figure of a large number of women exposed to chemical toxins, it is a wonder that we have not had an epidemic of birth defects and organ abnormalities. A study has pointed that about 40% to 50% of all conceptions are eliminated before week 20 of gestation by way of a safety mechanism which helps to reduce the number of birth defects Acetaminophen, considered the safest of all over-the-counter analgesics, has been reported to induce fatal liver necrosis in man and animals.

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7

Hook, Ernest B. "Folic acid: Abortifacient or pseudoabortifacient?" American Journal of Medical Genetics 92, no. 5 (2000): 301–2. http://dx.doi.org/10.1002/1096-8628(20000619)92:5<301::aid-ajmg1>3.0.co;2-j.

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8

Hopson, Dana L., and Jennifer Ross. "Maternal Abortifacient use for Clandestine Abortion." Academic Forensic Pathology 6, no. 4 (2016): 663–72. http://dx.doi.org/10.23907/2016.062.

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Abortion is a highly debated topic. In the United States and other developed countries, the vast majority of abortions performed are done in a clinical setting or under the supervision of clinical staff. However, clandestine abortions still occur. Previously published reports have described clandestine abortions performed using crude and often dangerous methods. In the United States, published reports on the clandestine use of medications for abortions is rare. We report a series of cases in which maternal use of misoprostol and or a combination of misoprostol and mifepristone was used or suspected to have been used for the purpose of at-home pregnancy termination. These medications, purchased from Internet sites, were believed to have been shipped from countries outside of the United States. With ready accessibility to and increased prevalence of these sites on the Internet, it is likely that maternal abortifacient use will become more common in the future. This paper will provide guidance for the investigation and workup of these cases that come to the attention of the medical examiner or coroner.

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9

Colliton, William F. "Birth Control Pill: Abortifacient and Contraceptive." Linacre Quarterly 66, no. 4 (1999): 26–36. http://dx.doi.org/10.1080/20508549.1999.11877553.

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10

Dahm, D. "Abortifacient development should not be stifled." JAMA: The Journal of the American Medical Association 262, no. 13 (1989): 1876. http://dx.doi.org/10.1001/jama.262.13.1876.

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11

Alamoudi, Mariam K., Khulood A. Almehmadi, Md Sajid Ali, et al. "Ethnopharmacological Study on Nigella Sativa Seeds Extracts: Pharmacognostical Screening, Abortifacient Potential and its Evolution Parameters." Migration Letters 20, no. 8 (2023): 765–83. http://dx.doi.org/10.59670/ml.v20i8.5542.

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Current research investigates the abortifacient properties of Nigella sativa, a natural alternative to pharmaceutical abortifacients such as mifepristone. Abortion induced by mifepristone is often accompanied by distressing side effects, prompting the exploration of safer alternatives. Nigella sativa seeds were processed into coarse powder through grinding and subjected to ethanolic and aqueous extractions. Pregnant mice were administered extracts at 400 milligrams per kilogram of body weight, with a comparison group receiving 2.85 mg/kg p.o. of mifepristone. The study showed a significant decrease in fetal survival rates with nigella sativa extract treatment with the untreated control group exhibiting a 100% survival rate and the 400 mg/kg p.o. Dose groups showed rates of 26.66% for aqueous extract and 33.33% for ethanolic extract. Importantly, none of the fetuses in the mifeprin-treated group survived. The results indicate a promising 70% abortion rate with well-tolerated doses of Nigella sativa extracts, highlighting the potential for natural alternatives to mitigate the side effects associated with mifepristone administration. This research underscores the importance of exploring botanical sources for safer and more tolerable options in induced abortion.

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12

Elemo, Olubunmi O., Akinwunmi A. Akinyede, Ibrahim A. Oreagba, Viola A. Nicholas-Okpara, and Jeremiah O. Unuofin. "Uterine Contractile Activity and Abortifacient Effect of the Aqueous Extract of Euphorbia heterophylla L. Leaves in Albino Rats." Pharmacology and Toxicology of Natural Medicines (ISSN: 2756-6838) 2, no. 1 (2022): 01–11. http://dx.doi.org/10.52406/ptnm.v2i1.14.

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Background and Purpose: Euphorbia heterophylla Linn. (Euphorbiaceae) is a promising medicinal plant used as an oxytocic in folkloric medicine. The study investigated the uterotonic and abortifacient effects of the aqueous leaf extract of Euphorbia heterophylla (AEEH).  Methods: GC-MS analysis of AEEH was done. In vitro experiment on the contractile activity of AEEH was conducted on the uterus of nulliparous female Sprague Dawley rats using an isolated organ bath. The abortifacient activity of the extract was determined in pregnant rats orally administered 50, 100, 200, and 400 mg/kg AEEH for five consecutive days. Results: GC-MS analysis of AEEH revealed high amounts of 1-butanol 3-methyl acetate, benzofuran,2,3-dihydro-, 2-methoxy-4-vinyl phenol, and sucrose. Some of the classes of compounds identified in the extract such as phenols, terpenoids, fatty acids, aldehydes, steroid, and glucoside have been associated with uterotonic and abortifacient properties. The extract (0.125-4 mg/mL) was able to enhance the contractile activity of uterine smooth muscles (EC50 = 3.39 × 10-1 mg/mL) similar to oxytocin (EC50 = 3.99 × 10-4 mg/mL) and acetylcholine (EC50=2.68 × 10-4 mg/mL). Pre-treatment with salbutamol, indomethacin, and stimulation in a calcium-deprived medium significantly (P<0.0001) reduced uterine contractions induced by cumulative concentrations of the aqueous extract. However, there was no significant change in uterine contraction in tissues pre-treated with atropine. The aqueous extract induced abortion in 50%, and 83.33% of the animals at 200, and 400 mg/kg respectively when orally administered to pregnant rats for five days.  Conclusions: This study demonstrates the uterotonic and abortifacient effects of AEEH and supports the ethnomedicinal use of the plant as an oxytocic.

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13

Tanne, Janice Hopkins. "US doctors debate safety of abortifacient drug." BMJ 332, no. 7533 (2006): 71.3. http://dx.doi.org/10.1136/bmj.332.7533.71-b.

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14

&NA;. "Mifepristone appears most effective as an abortifacient." Inpharma Weekly &NA;, no. 736 (1990): 8. http://dx.doi.org/10.2165/00128413-199007360-00017.

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15

Parton, K., D. Gardner, and N. B. Williamson. "Isocupressic acid, an abortifacient component ofCupressus macrocarpa." New Zealand Veterinary Journal 44, no. 3 (1996): 109–11. http://dx.doi.org/10.1080/00480169.1996.35946.

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16

Akah, P. A. "Abortifacient activity of some Nigerian medicinal plants." Phytotherapy Research 8, no. 2 (1994): 106–8. http://dx.doi.org/10.1002/ptr.2650080212.

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17

Srikanth, Muppaneni, Battu Ganga Rao, Mallikarjuna Rao Talluri, and T. Rajananda Swamy. "Abortifacient and Antioxidant Activities of Avicennia marina." International Letters of Natural Sciences 33 (January 2015): 12–26. http://dx.doi.org/10.18052/www.scipress.com/ilns.33.12.

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The current study was intended to evaluate abortifacient and antioxidant activity of Avicennia marina leaves extracts. Abortifacient activity was evaluated in rats, compared with standard drug (Mifepristone) and antioxidant activity was evaluated by using three free radicals (Superoxide, Hydroxyl and DPPH) compared with Ascorbic acid. The extracts were showed pre implantation loss, post implantation loss of implantations and decreased the survival ration of foetuses. Among all extracts hydroalcoholic extract showed better activity. The selected plant extracts showed concentration dependent percentage inhibition of free radicals. Among three extracts hydroalcoholic extract showed better activity with IC50 values on superoxide, hydroxyl and DPPH radicals were 203μg, 237μg and 143μg. From the results obtained during the study it the hydroalcoholic extract was used for the isolation of pure compounds, and isolated the different compounds (β-sitosterol, Lupeol and Betulinic acid).

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18

Srikanth, Muppaneni, Battu Ganga Rao, Mallikarjuna Rao Talluri, and T. Rajananda Swamy. "Abortifacient and Antioxidant Activities of <i>Avicennia</i> <i>marina</i>." International Letters of Natural Sciences 33 (January 27, 2015): 12–26. http://dx.doi.org/10.56431/p-nom357.

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The current study was intended to evaluate abortifacient and antioxidant activity of Avicennia marina leaves extracts. Abortifacient activity was evaluated in rats, compared with standard drug (Mifepristone) and antioxidant activity was evaluated by using three free radicals (Superoxide, Hydroxyl and DPPH) compared with Ascorbic acid. The extracts were showed pre implantation loss, post implantation loss of implantations and decreased the survival ration of foetuses. Among all extracts hydroalcoholic extract showed better activity. The selected plant extracts showed concentration dependent percentage inhibition of free radicals. Among three extracts hydroalcoholic extract showed better activity with IC50 values on superoxide, hydroxyl and DPPH radicals were 203μg, 237μg and 143μg. From the results obtained during the study it the hydroalcoholic extract was used for the isolation of pure compounds, and isolated the different compounds (β-sitosterol, Lupeol and Betulinic acid).

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19

&NA;. "In Brazil, misoprostol is the most popular abortifacient ???" Reactions Weekly &NA;, no. 363 (1991): 1. http://dx.doi.org/10.2165/00128415-199103630-00002.

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20

Stegelmeier, B. L., D. R. Gardner, L. F. James, K. E. Panter, and R. J. Molyneux. "The Toxic and Abortifacient Effects of Ponderosa Pine." Veterinary Pathology 33, no. 1 (1996): 22–28. http://dx.doi.org/10.1177/030098589603300103.

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Ponderosa pine needles cause abortion and a poorly described toxicosis when eaten by cattle. In previous trials, the abortifacient compound of pine needles was identified as isocupressic acid. At abortifacient doses, isocupressic acid caused no other toxicosis. However, other pine needle fractions, similar in composition to several commercially available rosin products, caused no abortion but were very toxic. The purpose of this study was to describe the toxicoses of ponderosa pine, compare its toxicity with other rosin and related pine products, and identify the toxin. Four groups of three pregnant beef cows each were treated with either ponderosa pine tips, rosin gum, dehydroabietic acid, or ground alfalfa. The cows treated with pine tips aborted, had retained placentas with endometritis, and developed both renal and neurologic lesions. The cattle treated with rosin gum or dehydroabietic acid did not abort but developed similar signs and lesions of intoxication. Clinical signs of intoxication included anorexia, mild rumen acidosis, dyspnea, paresis progressing to paralysis, and death. Clinical biochemical results, suggestive of renal, hepatic, and muscular disease, included azotemia, hypercreatinemia, hyperphosphatemia, proteinuria, and marked elevations of various serum enzymes. Histologically, all poisoned animals had nephrosis, vacuolation of basal ganglia neuropil with patchy perivascular and myelinic edema, and skeletal myonecrosis. The alfalfa-treated controls were normal. These findings suggest that ponderosa pine needles and tips are both abortifacient and toxic. Because the lesions caused by pine tips, rosin gum, and dehydroabietic acid are similar, toxicosis is most likely due to the diterpene abietane acids, common in all three.

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21

Grimes, David A., and Rebecca J. Cook. "Mifepristone (RU 486) — An Abortifacient to Prevent Abortion?" New England Journal of Medicine 327, no. 15 (1992): 1088–89. http://dx.doi.org/10.1056/nejm199210083271509.

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22

Tonti-Filippini, Nicholas. "The Pill: Abortifacient or Contraceptive? A Literature Review." Linacre Quarterly 62, no. 1 (1995): 5–28. http://dx.doi.org/10.1080/20508549.1995.11878286.

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23

Roberge, Lawrence F. "Abortifacient Vaccine Technology: Overview, Hazards, and Christian Response." Linacre Quarterly 62, no. 3 (1995): 67–75. http://dx.doi.org/10.1080/20508549.1995.11878318.

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24

Lutterodt, G. D. "Abortifacient properties of an extract from sida veronicaefolia." Journal of Ethnopharmacology 23, no. 1 (1988): 27–37. http://dx.doi.org/10.1016/0378-8741(88)90112-2.

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25

Kazerooni, Talieh, Kazem Mousavizadeh, Alireza Abdollahee, Mohsen Sarkarian, and Alireza Sattar. "Abortifacient effect of Prangos ferulacia on pregnant rats." Contraception 73, no. 5 (2006): 554–56. http://dx.doi.org/10.1016/j.contraception.2005.11.001.

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26

Miller, John L. "Abortifacient drug approved for restricted, physician-only distribution." American Journal of Health-System Pharmacy 57, no. 21 (2000): 1940. http://dx.doi.org/10.1093/ajhp/57.21.1940a.

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27

Beckman, Bill. "Study Confirms Plan B is Abortifacient and Unreliable." Linacre Quarterly 75, no. 2 (2008): 91. http://dx.doi.org/10.1179/002436308803889657.

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28

Severyn, Kristine M. "Abortifacient Drugs and Devices: Medical and Moral Dilemmas." Linacre Quarterly 57, no. 3 (1990): 50–67. http://dx.doi.org/10.1080/00243639.1990.11878070.

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29

Tsui, Kuan-Hao, Jyun-Yuan Wang, Leang-Shin Wu, and Chih-Hsien Chiu. "Molecular Mechanism of Isocupressic Acid Supresses MA-10 Cell Steroidogenesis." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–12. http://dx.doi.org/10.1155/2012/190107.

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Consumption of ponderosa pine needles causes late-term abortions in cattle and is a serious poisonous plant problem in foothill and mountain rangelands. Isocupressic acid (IA) is the component of pine needles responsible for the abortifacient effect, its abortifacient effect may be due to inhibition of steroidogenesis. To investigate the more detail molecular mechanism, we used MA-10 cell, which is wild used to investigate molecular mechanism of steroidogenesis, to characterize the molecular mechanisms underlying the actions of IA in more detail. In this report, we focus on the function of IA on important steroidogenic genes, including steroidogenic acute regulatory protein (StAR), cytochrome P450 cholesterol side-chain cleavage (P450scc), and 3β-hydroxysteroid dehydrogenase (3β-HSD). We found that IA does not affect enzyme activities of these genes but inhibits transcription of P450scc and translation of StAR and P450scc through attenuating cAMP-PKA signaling. Thus, steroid productions of cells were suppressed.

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30

Terangpi, Reena, and Farishta Yasmin. "Medicinal Plants used as Abortifacient among Karbis of Assam, India." Journal of Natural Remedies 21, no. 4 (2021): 297. http://dx.doi.org/10.18311/jnr/2021/26142.

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Living a healthy reproductive life is one of the major concerns among women. Unwanted conception among rural tribal population like the Karbis is managed by using traditional medicinal plants. The present work was carried out to document the traditional uses of medicinal plants or its products for inducing abortion. Field studies were undertaken in different Karbi dominated areas of Karbi Anglong district using informal and formal conversations, discussions, and semiâ€“structured and unstructured interviews involving 35 informants (male 11 and female 24). A total of twelve medicinal plants, belonging to twelve genera and twelve families were reported to be used for inducing abortion. The study showed that the Karbis are rich in ethnomedicinal practises using plant and its products as an abortifacient. The knowledge of the practises of traditional medicines needs to be incorporated with scientific methods and concepts for betterment of future mankind. Biochemical evaluations of abortifacient plants need to be studied for its active phytocompound responsible for inducing abortion.

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31

Fathima T, Suresh Joghee, and Ann Maria Alex. "An Updated Review: Adhatoda vasica." International Journal of Research in Pharmaceutical Sciences 11, no. 3 (2020): 3981–87. http://dx.doi.org/10.26452/ijrps.v11i3.2590.

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The present review mainly focuses on the morphological and pharmacological activities of the Adhatoda vasica belonging to the family Acanthaceae, which is commonly referred to as Adosa or Adsogi. It also focuses on the evidence based therapeutic uses of A.vasica in various experimental models. This plant is found in all the ecosystem in India and other parts of the world as well. Because of its greater availability and multitude of pharmacological activities, the plant is being used in the treatment of numerous diseases. Extracts of various parts of the plants such as bark, root, leaf, flower, fruit and many a times, the whole plants are used in the management of pain, inflammation, asthma, cold, cough, diabetes, bronchitis, diarrhea, dysentery and other upper respiratory diseases and it is also used to heal wounds; is utilised as an insecticide, and also used as abortifacient. In asthma and acute stages of bronchitis, the extract of vasica offers an unflagging result by decreasing the thickness of the sputum. Because of the above mentioned reasons the plant has greater importance in the various systems of medicines such as Ayurveda, Siddha, and Unani. According to the texts, the plant has greater power on asthma, abortifacient and uterotonic. Numerous trials have been conducted to prove the effects of A.vasica on asthma which led to its inclusion in WHO manual. According to the present day studies the alkaloids such as vasicinone, vasicine, and oxyvasicine which are present in A.vasica are responsible for most of the activities. But extensive studies need to be conducted to understand the constituent responsible for abortifacient and uterotonic activity.

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32

Wu, L. S., Joyce C. Chen, S. Y. Sheu, et al. "Isocupressic Acid Blocks Progesterone Production from Bovine Luteal Cells." American Journal of Chinese Medicine 30, no. 04 (2002): 533–41. http://dx.doi.org/10.1142/s0192415x02000508.

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The needles of ponderosa pine (Pinus ponderosa Laws.) were reported to induce abortions when fed to late-term pregnant beef cows in North America. An in vivo study of pregnant cows suggested that isocupressic acid (IA) was the main abortifacient isolated from needles and bark of the pine. However, the mechanism of abortifacient activity of IA is not clear yet. In a pregnant cow, the corpus luteum of the ovary helps the maintenance of pregnancy by its progesterone production. This study involved the IA extracted from the root of the Taiwan cypress (Juniperus formosana) and used a frozen-thawed bovine luteal cell culture system to investigate the action of IA on progesterone production. Thawed bovine luteal cells (1 × 105 cells/ml/well) in M199 medium were cultured in 24-well culture plates at 37°C in a 5% CO 2 incubator. Ten ml of tested drugs, IA at 1 to 1000 ng/ml and/or ovine luteinizing hormone (oLH) at 1 to 100 ng/μl or 8-bromo-cyclic adenosine monophosphate (8-Br-cAMP) with 0.1-10 mM, were added into each well. After 4 hours of incubation, the media were harvested and assayed for progesterone by an enzyme immunoassay. Progesterone production from cells was the indicator used to evaluate the action of IA. All tested doses of IA significantly inhibited progesterone production in both basal and oLH stimulating conditions. Also those dosages inhibited cyclic adenosine-3', 5'- monophosphate (cAMP) stimulation, suggesting a post-cAMP mechanism is involved in the IA action. We concluded that IA can induce pregnant cows to abort partly through blocking luteal function and may be identified as a new abortifacient chemical.

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33

NAKAYAMA, Luiza, José Silva de SOUZA, Otávio Mitio OHASHI, and WiIiam G. VALE. "ABORTIFACIENT EFFECTS OF Ananas ananassoides BAK. (Ananai) IN RATS." Acta Amazonica 23, no. 1 (1993): 77–82. http://dx.doi.org/10.1590/1809-43921993231082.

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The tea made from the infrutescense (corresponding to the edible part plus its cover) of ananai (Ananas ananassoidesBAK.) was administered to pregnant rats, during the period of embryos implantation (5th - 6th day through pregnancy). The animals were slaughtered on the 14th - 15th day through the pregnancy and average rates of implantation and resorption were stimated.

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34

Shapira, Zvia, J. Terkel, Y. Egozi, A. Nyska, and J. Friedman. "Abortifacient potential for the epigeal parts of Peganum harmala." Journal of Ethnopharmacology 27, no. 3 (1989): 319–25. http://dx.doi.org/10.1016/0378-8741(89)90006-8.

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35

Choudhury, M. K., A. L. Phillips, and A. Mustapha. "Pharmacological studies ofStriga senegalensis Benth (Scrophulariaceae) as an abortifacient." Phytotherapy Research 12, no. 2 (1998): 141–43. http://dx.doi.org/10.1002/(sici)1099-1573(199803)12:2<141::aid-ptr201>3.0.co;2-t.

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36

Benavides, Julio, Marta González-Warleta, Noive Arteche-Villasol, Valentín Pérez, Mercedes Mezo, and Daniel Gutiérrez-Expósito. "Ovine Neosporosis: The Current Global Situation." Animals 12, no. 16 (2022): 2074. http://dx.doi.org/10.3390/ani12162074.

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In the past 20 years, Neospora caninum infection in sheep has been reported in at least 31 countries worldwide from all sheep-rearing continents (Europe, Asia, the Americas, Africa, and Oceania), and its role as an abortifacient agent is becoming more evident. Most studies of ovine neosporosis have focused on its epidemiology, based primarily on serological analysis, with only a few studies investigating the actual presence of the parasite by PCR and/or IHC. Individual seroprevalence rates were highly variable between countries, and even between regions within the same country, ranging from 0.0% to 67.4% positive. Furthermore, most of the studies were not directly comparable due to differences in experimental designs, sample sizes, husbandry systems, ecological factors, and serological tests (e.g., IFAT, ELISA, MAT, Western blot). The latter, along with the scarcity of studies on the relevance of N. caninum as an abortifacient agent, may bias the perception of the importance of this disease. This review summarizes the situation of N. caninum infection in sheep using all available published studies describing natural ovine neosporosis. The epidemiology shows that ovine neosporosis is found worldwide, and it poses a relevant risk to the sustainability of sheep flocks.

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37

Yang, Na, Xia Cui, Weifeng Qian, Shanshan Yu, and Qun Liu. "Survey of nine abortifacient infectious agents in aborted bovine fetuses from dairy farms in Beijing, China, by PCR." Acta Veterinaria Hungarica 60, no. 1 (2012): 83–92. http://dx.doi.org/10.1556/avet.2012.007.

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Abortion in dairy cattle causes considerable economic losses to the dairy industry. Aborted fetuses and samples from the corresponding aborting dams from 12 dairy herds in Beijing were tested for 9 abortifacient infectious pathogens by PCR between 2008 and 2010. From a total of 80 abortion cases collected during this period, infectious agents were detected in 45 (56.3%) cases, 22 (48.9%) of which represented co-infections with two or three infectious agents. The detected pathogens included infectious bovine rhinotracheitis virus (36.3%) andNeospora caninum(31.3%), followed by bovine viral diarrhoea virus (7.5%),Brucella abortus(6.3%),Tritrichomonas foetus(5%) andToxoplasma gondii(1.3%).Campylobacter fetus, Coxiella burnetiiandChlamydophila psittaciwere not detected in any abortion case. Findings from this study indicated that infectious bovine rhinotracheitis virus andNeospora caninumwere the main potential causes of abortions in Beijing dairy herds, whereas the bacterial pathogens were not, in contrast to reports from other countries. This is the first study to test nine abortifacient infectious agents by PCR at the same time, and it is also the first time to report the involvement of a variety of infectious agents in bovine abortion cases in China.

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Singh, Reeta, Pankhuri Shukla, Vani Aditya, and Ruma Sarkar. "Unsafe abortion: journey from unmet needs to denial for contraception." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 13, no. 7 (2024): 1688–92. http://dx.doi.org/10.18203/2320-1770.ijrcog20241760.

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Background: Easy over the counter availability of abortion pills leads to unsupervised rampant use of the pills which further results in physical and mental health complications and social and financial burdens for women, communities and health systems. Aims and objectives were to study the sociodemographic, obstetric and clinical profile of the women presenting with unsupervised intake of abortifacient, and to study the acceptance of post abortal contraception and also the method of contraception accepted. Methods: This present study was carried out in women with history of unsupervised self-intake of abortifacient and presenting with complain of bleeding per vaginum and various other complications in the emergency or outpatient department of obstetrics and gynaecology between October 2022 to September 2023 at Nehru Hospital, BRD Medical college, Gorakhpur. Complete personal, sociodemographic and obstetric history was obtained. Complete general and systemic examination was done and all routine investigations were sent. Results: A total of 197 women were enrolled in this study. In our study majority 39.48% (n=77) of women were between 25-30 years age. 56.34% (n=111) belonged to low socioeconomic strata and 69.54% (n=137) resided in urban area. 42.63% (n=84) were gravida 3 or more. 22.8% cases took abortifacient pills beyond 9 weeks of gestation. All patients procured the contraceptive from local practitioner, quacks, medical stores and chemists without any consultation from gynecologist. Most frequent complain was Chronic bleeding per vaginum with RPOC (n=112, 56.85%). Majority patients had moderate to severe anemia and 53.8% (n=106) required blood transfusion. 2.03% (n=4) presented with features of sepsis and 2.03% (n=4) presented with ruptured ectopic. Majority (n=160, 81.21%) didn’t opt for post abortion contraception. Conclusions: One major contributor to unsafe abortions is the easy availability of abortion pills. These pills should be restricted from over-the-counter sales and made available to the public only through authorized MTP centres with a proper prescription.

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Ughagwu, IC, OI Adeyemi, and JA Aladesanmi. "Abortifacient Activity of Pleioceras Barteri Baill. In Rats." Nigerian Journal of Natural Products and Medicine 17, no. 1 (2014): 43. http://dx.doi.org/10.4314/njnpm.v17i1.1.

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Srikanth, M., T. Rajananda Swamy, T. Mallikarjuna Rao, and B. Ganga Rao. "Abortifacient and antioxidant activities of different extracts of Musa rosacea." Asian Pacific Journal of Reproduction 2, no. 3 (2013): 174–77. http://dx.doi.org/10.1016/s2305-0500(13)60142-6.

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Schönhöfer, PeterS. "Brazil: Misuse of misoprostol as an abortifacient may induce malformations." Lancet 337, no. 8756 (1991): 1534–35. http://dx.doi.org/10.1016/0140-6736(91)93212-r.

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Kubota, Shigeo, H. W. Yeung та Jen Tsi Yang. "Conformation of abortifacient proteins: Trichosanthin, α-momorcharin and β-momorcharin". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 871, № 1 (1986): 101–6. http://dx.doi.org/10.1016/0167-4838(86)90138-x.

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Yeung, H. W., Z. Feng, W. W. Li, W. K. Cheung, and T. B. Ng. "Abortifacient activity in leaves, roots and seeds of Phytolacca acinosa." Journal of Ethnopharmacology 21, no. 1 (1987): 31–35. http://dx.doi.org/10.1016/0378-8741(87)90091-2.

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Offiah, Veronica N., and Immaculata I. Anyanwu. "Abortifacient activity of an aqueous extract of Spondias mombin leaves." Journal of Ethnopharmacology 26, no. 3 (1989): 317–20. http://dx.doi.org/10.1016/0378-8741(89)90104-9.

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Yeung, H. W., S. O. Leung та K. N. Leung. "Immunosuppressive activities of two abortifacient proteins - α- and β-momorcharin". International Journal of Immunopharmacology 7, № 3 (1985): 373. http://dx.doi.org/10.1016/0192-0561(85)90377-7.

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TOYOKAWA, Shunsuke, Tadahiro TAKEDA, Yukio KATO, Katsumi WAKABAYASHI, and Yukio OGIHARA. "The Complete Amino Acid Sequence of an Abortifacient Protein, Karasurin." CHEMICAL & PHARMACEUTICAL BULLETIN 39, no. 5 (1991): 1244–49. http://dx.doi.org/10.1248/cpb.39.1244.

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Tao, Zong Jin, Zhi Min Shen, and Jen Tsi Yang. "Conformation of the abortifacient protein pinellin: A circular dichroic study." Journal of Protein Chemistry 12, no. 4 (1993): 387–91. http://dx.doi.org/10.1007/bf01025038.

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Puri, Chander P., Rohini K. Patil, Sanjiv D. Kholkute, Walter A. G. Elger, and Xavier R. Swamy. "Progesterone antagonist lilopristone: A potent abortifacient in the common marmoset." American Journal of Obstetrics and Gynecology 161, no. 1 (1989): 248–53. http://dx.doi.org/10.1016/0002-9378(89)90274-3.

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Costa, Kassiane Cristine da Silva, Suzana Barbosa Bezerra, Clevanice Moreira Norte, Luciana Macatrão Nogueira Nunes, and Tiago Moreira de Olinda. "Medicinal plants with teratogenic potential: current considerations." Brazilian Journal of Pharmaceutical Sciences 48, no. 3 (2012): 427–33. http://dx.doi.org/10.1590/s1984-82502012000300009.

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The aim of this study was to present the implications of the use of herbs during pregnancy, pointing out those that should be avoided during this condition because of their abortifacient and/or teratogenic potential. We carried out searches in the databases ScienceDirect, Scielo and Google Scholar, adopting as criteria for inclusion: book chapters and/or complete articles (with abstract), available in English, Portuguese or Spanish, published from 1996 to in 2011. After a pre-selection of 83 articles, 49 bibliographies were used in the manufacturing end of the article, where 25 were from the Scielo database, 18 from ScienceDirect and 6 from Google Scholar. From the articles studied, we identified the four most commonly used plants as emmenagogue/abortifacient agents by patients of the Department of Prenatal SUS: senne, arruda, boldo and buchinha-do-norte or cabacinha. Thus, we conclude that people often adhere to the maxim "if it's natural, it does no harm" in their rational use of natural products, without the right guidance, believing that these products are safe to use. This usage is even more worrisome among the elderly, pregnant women and children. Regarding the safety of these products, some information and reliable data are scarce or contradictory.

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CVETOJEVIC, Đ., V. MILICEVIC, B. KURELJUSIC, and B. SAVIC. "Seroprevalence of Neospora caninum in dairy cows in Belgrade city area, Serbia." Journal of the Hellenic Veterinary Medical Society 69, no. 2 (2018): 979. http://dx.doi.org/10.12681/jhvms.18026.

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The protozoan parasite Neospora caninum is one of the most important abortifacient pathogen in cattle. Serological investigations are often used in order to estimate seroprevalence in herds. Aims of our study were to determine the seroprevalence among aborting and non-aborting dairy cattle in Belgrade city area as well as epidemiological factors that are important for N. caninum infection. Using commercial ELISA kit, we examined 188 sera. Out of 188, 142 samples originated from pregnant (non-aborting) cows from five farms, while 46 were from cows who had aborted. Overall seroprevalence was 25% (48/188). Seroprevalence was significantly higher (p≤0.05) in aborting than in non-aborting group of cows (37% and 21.1% respectively). At least one positive sample was detected on four (80%) out of five examined farms while seroprevalence among farms varied from 0 to 43.5%. On all examined farms crucial epizootiological factors (presence of dogs and low biosecurity measures) that favor the maintenance and spreading of the infection were identified. Our study revealed the presence of N. caninum antibodies in population of dairy cows in Belgrade city area. Infection is established in enzootic pattern on examined farms and high seroprevalence among aborting cows suggests that N. caninum could be important abortifacient pathogen.

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