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Journal articles on the topic 'Abortive drugs'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Muralinath, E., Devi Pooja, Chbukdhara Prasanta, et al. "The Impact of Drugs on Migraine: A Comprehensive Analysis." Journal of Mental health, Psychiatric and Psychosocial Nursing 2, no. 1 (2023): 1–4. https://doi.org/10.5281/zenodo.10389781.

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<em>MIGRAINE, a neurological disorder, manifested by severe headaches, frequently accompanied by nausea, sensitivity to light and sounds, influences millions of people worldwide. A very few drugs decrease the frequency and severity vof MIGRAINE attacks. Beta blockers are also helpful in decreasing migraine by controlling blood vessel constriction. Anti-depressants like amitryptalline are more useful to manage migraines because of their impact on serotonin levels, a neurotransmitter related to the migraine development. Anti-seizure drugs namely topiramate and valproate decrease migraine frequen

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Kay, M. "Unsafe abortion: why restricting abortive drugs only makes a bad situation worse." BMJ 346, may31 4 (2013): f3159. http://dx.doi.org/10.1136/bmj.f3159.

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Wilmańska, Dorota, Malgorzata Czyz, Kazimierz Studzian, Mariola K. Piestrzeniewicz, and Marek Gniazdowski. "Effects of Anticancer Drugs on Transcription in vitro." Zeitschrift für Naturforschung C 56, no. 9-10 (2001): 886–91. http://dx.doi.org/10.1515/znc-2001-9-1034.

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AbstractThe effects of DNA interacting drugs on: (1) total RNA synthesis catalyzed by E.coli and T7 RNA polymerase; (2) synthesis of the initiating dinucleotide (pppApU) by E .coli RNA polymerase (“abortive initiation“); (3) elongation of RNA chains synthesized by T7 RNA polymerase on pT7-7 plasmid DNA bearing T7 RNA polymerase promoter ϕ 10 with human Cu/Zn superoxide dismutase coding sequence, (4) interaction of transcription factor Sp1 and its binding site were studied. Intercalating ligands which form quickly dissociating complexes with DNA (anthracyclines, proflavine, ethidium bromide) ar

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Platzbecker, Katharina, Fanny P. Timm, Sait Ashina, Timothy T. Houle, and Matthias Eikermann. "Migraine treatment and the risk of postoperative, pain-related hospital readmissions in migraine patients." Cephalalgia 40, no. 14 (2020): 1622–32. http://dx.doi.org/10.1177/0333102420949857.

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Background Migraine treatment may mitigate migraine and associated pain in the perioperative period. Objective The aim of the study was to estimate the effect of perioperative acute and prophylactic migraine treatment on the risk of postoperative 30-day hospital readmission with an admitting diagnosis specifying any pain complaints among migraine patients. Design Electronic health records were analysed for 21,932 adult migraine patients undergoing surgery between 2005 and 2017 at Beth Israel Deaconess Medical Center and Massachusetts General Hospital in Boston, Massachusetts, USA. Methods Peri

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Priyadarsini, Baskaran Venkatraman Karthikeayan and Anusha Natarajan. "Recent Advances in Drug Therapy of Migraine." British Journal of Pharmaceutical and Medical Research 04, no. 04 (2019): 2035–47. https://doi.org/10.24942/bjpmr.2019.543.

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Migraine is one of the foremost disabling diseases that preponderantly affects the feminine population. The clinical spectrum of migraine encompasses four stages- the prodrome, aura, the headache phase and also the postdrome. The management of migraine is directed at aborting and preventing the headache, the associated incapacitating symptoms (like photophobia, phonophobia, olfactive hypersensitivity, allodynia, nausea, vomiting, etc.) and also the symptoms of aura (like visual phenomena, sensory phenomena, language aura etc.). The pathophysiology of migraine includes the neuronal theory, the

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Silva-Néto, Raimundo Pereira, Carla Jevoux, and Abouch Krymchantowski. "Preventive and abortive treatment of migraine with traditional drugs. The state of the art." Headache Medicine 14, no. 3 (2023): 133–43. http://dx.doi.org/10.48208/headachemed.2023.27.

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IntroductionMigraine is a chronic neurological disease, with a prevalence of 15.2% in Brazil. It is 2.2 times more prevalent in women, predominantly in the 18-50 age group. Its pathophysiological mechanism is still not completely understood. Possibly headache attacks and symptoms are associated with cortical spreading depression, the trigeminovascular system, neurogenic inflammation, vasodilation and genetic vulnerability.ObjectiveThis is a narrative review of preventive and abortive treatment of migraine.CommentMigraine treatment is based on three pillars: patient education, treatment of the

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Pestun, I. V., G. S. Babicheva, S. V. Zhadko, N. G. Malinina, I. V. Bondarieva, and I. V. Sofronova. "Legal and ethical dilemmas in the process of providing information to users of hormonal contraceptives." Social Pharmacy in Health Care 9, no. 4 (2023): 11–21. http://dx.doi.org/10.24959/sphhcj.23.305.

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Aim. To elucidate legal and ethical dilemmas in the process of providing information to consumers of hormonal contraceptives (HC) at the pharmaceutical market of Ukraine and search for ways to solve them. Materials and methods. The method of logical and content formulation of the problem, systematic and statistical methods, desk and field methods of marketing research, such as analysis of patient information leaflets for HC, the content analysis of publications in scientific and practically-oriented medical and pharmaceutical publications, the questionnaire survey method, tabular and gra

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Rothrock, JF. "Clinical Studies of Valproate for Migraine Prophylaxis." Cephalalgia 17, no. 2 (1997): 81–83. http://dx.doi.org/10.1046/j.1468-2982.1997.1702081.x.

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Within the last decade our understanding of the pathophysiologic mechanisms which generate migraine has expanded considerably. Accompanying these advances in basic science, new agents designed to treat migraine acutely have exhibited unprecedented pharmacologic selectivity and clinical efficacy. While these abortive agents clearly can provide many migraine patients with a degree of headache control they previously have not enjoyed, such treatment typically will not provide lasting benefit to individuals whose headaches are more pervasive and may require stabilization through effective prophyla

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Martami, Fahimeh, Mansoureh Togha, Maryam Seifishahpar, et al. "The effects of a multispecies probiotic supplement on inflammatory markers and episodic and chronic migraine characteristics: A randomized double-blind controlled trial." Cephalalgia 39, no. 7 (2019): 841–53. http://dx.doi.org/10.1177/0333102418820102.

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Background The current study was designed to assess the effect of supplementation with a 14-strain probiotic mixture on episodic and chronic migraine characteristics. Methods Forty episodic and 39 chronic migraine patients who completed this randomized double-blind controlled trial received two capsules of multispecies probiotic or placebo. The migraine severity was assessed by visual analog scale (VAS). The number of abortive drugs consumed, migraine days, frequency and duration of attacks were recorded on paper-based headache diaries. Serum tumor necrosis factor alpha (TNF-α) and C- reactive

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Sokolov, A. Y., I. B. Skiba, and O. A. Lyubashina. "Neurophysiological and Vascular Mechanisms of Action of the Serotoninergic Drugs for Abortive Migraine Treatment." Успехи физиологических наук 54, no. 3 (2023): 53–76. http://dx.doi.org/10.31857/s0301179823030050.

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Abstract—Migraine is a form of primary headache that affects at least 10% of the world’s population. In addition to recommendations for modifying the patient’s lifestyle, migraine management involves stopping an attack that’s already occurred and/or preventing its occurrence. In the abortive treatment of this cephalalgia, both non-specific (eg, non-opioid analgesics) and specific pharmacological agents, can be used. The latter include, in particular, serotonergic drugs of the classes of triptans (selective 5-HT1B/1D receptor agonists), ditans (selective 5-HT1F-mimetics), and ergot alkaloids (n

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Sabharwal, Geetika, and Timothy Craig. "Pediatric hereditary angioedema: an update." F1000Research 6 (July 24, 2017): 1205. http://dx.doi.org/10.12688/f1000research.11320.1.

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Hereditary angioedema (HAE) with C1-inhibitor (C1-Inh) deficiency (C1-Inh-HAE) is a rare, life-threatening, and disabling genetic disorder characterized by self-limited tissue swelling caused by deficiency or dysfunction of C1-Inh. Our aim in this update is to discuss new advances in HAE therapy, focusing mainly on the various treatment options that have become available recently and also drugs that are under trial for prophylaxis to prevent attacks. There is a paradigm shift to where the treatment of HAE is headed, focusing now on prophylactic treatment rather than abortive management.

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Kafarov, Telman. "CORONAVIRUS AND VACCINATION: MEDICAL, BIOETHICAL AND CONFESSIONAL DIMENSIONS." Bioethics 28, no. 2 (2021): 17–21. http://dx.doi.org/10.19163/2070-1586-2021-2(28)-17-21.

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This article discusses some controversial issues at the intersection of medicine, biology, philosophy, theology, religious studies and bioethics that have arisen in connection with the coronavirus and vaccination of the population, which are solved differently from the positions of different worldviews and faiths. It shows some of the costs of adapting religious denominations to the regulation of life in all spheres during the coronavirus period. It is proved that one of the reasons for the rapid spread of the virus is some actions of churches, mosques and synagogues in the direction of ensuri

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Olmedo-Pelayo, Joaquín, Diana Rubio-Contreras, and Fernando Gómez-Herreros. "Canonical non-homologous end-joining promotes genome mutagenesis and translocations induced by transcription-associated DNA topoisomerase 2 activity." Nucleic Acids Research 48, no. 16 (2020): 9147–60. http://dx.doi.org/10.1093/nar/gkaa640.

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Abstract DNA topoisomerase II (TOP2) is a major DNA metabolic enzyme, with important roles in replication, transcription, chromosome segregation and spatial organisation of the genome. TOP2 is the target of a class of anticancer drugs that poison the DNA-TOP2 transient complex to generate TOP2-linked DNA double-strand breaks (DSBs). The accumulation of DSBs kills tumour cells but can also result in genome instability. The way in which topoisomerase activity contributes to transcription remains unclear. In this work we have investigated how transcription contributes to TOP2-dependent DSB format

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Ayata, C. "Spreading Depression: From Serendipity to Targeted Therapy in Migraine Prophylaxis." Cephalalgia 29, no. 10 (2009): 1095–114. http://dx.doi.org/10.1111/j.1468-2982.2009.01982.x.

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Despite the relatively well-characterized headache mechanisms in migraine, upstream events triggering individual attacks are poorly understood. This lack of mechanistic insight has hampered a rational approach to prophylactic drug discovery. Unlike targeted abortive and analgesic interventions, mainstream migraine prophylaxis has been largely based on serendipitous observations (e.g. propranolol) and presumed class effects (e.g. anticonvulsants). Recent studies suggest that spreading depression is the final common pathophysiological target for several established or investigational migraine pr

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Antonaci, Fabio, Natascia Ghiotto, and Maurizio Evangelista. "An Overview of the Treatment Options for Acute Migraine." European Neurological Review 6, no. 4 (2011): 265. http://dx.doi.org/10.17925/enr.2011.06.04.265.

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Migraine is a primary headache disorder associated with a high socioeconomic burden. The first step in effective migraine management, following confirmation of the diagnosis, is patient education: the condition is carefully explained, to ensure that it is properly understood, and realistic expectations are set. The choice of acute treatment has changed over time as the available therapeutic options have increased. Abortive migraine therapy can be either specific (ergot derivatives and triptans) or non-specific (analgesics and non-steroidal anti-inflammatory drugs). Even though acute symptomati

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Angra, Monika, Amit Bhardwaj, Ashish Sharma, et al. "Is Single-Drug Prophylaxis in Migraine Prevention a Better Option than Combination Therapy? An Observational Study in a Rural Tertiary Care Center in North West India." Journal of Neurosciences in Rural Practice 10, no. 03 (2019): 479–82. http://dx.doi.org/10.1055/s-0039-1698282.

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Abstract Background Migraine is a primary headache disorder that has a great impact on quality of life of patients. Pharmacologic therapy may be given in acute or abortive form and in the form of preventive therapy. In what form is preventive therapy to be given? Whether monotherapy is to be used or combination therapy? In what cases does combination therapy fare better than monotherapy? These queries are still unanswered. Materials and Methods All patients with headache reporting to the outpatient department were screened, and those fulfilling inclusion criteria were included in the study. Th

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Fullerton, Terence. "Recent Advances in the Understanding and Treatment of Migraine." Journal of Pharmacy Practice 6, no. 6 (1993): 253–70. http://dx.doi.org/10.1177/089719009300600602.

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Migraine is a disorder that afflicts more than 23 million individuals in the United States alone. The disorder is characterized by paroxysmally recurring attacks, which are moderately to severely disabling. The migraine attack is typified by a severe, usually unilateral headache, which is pulsatile in quality, and by one or more concomitant symptoms, such as nausea, vomiting, photophobia, and/or phonophobia. Because of its debilitating nature, migraine causes significant morbidity among sufferers, including lost time from work or school, and inability to perform other normal daily activities d

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Wames-van der Heijden, EA, CC Tijssen, and ACG Egberts. "Treatment Choices and Patterns in Migraine Patients With and Without a Cardiovascular Risk Profile." Cephalalgia 29, no. 3 (2009): 322–30. http://dx.doi.org/10.1111/j.1468-2982.2008.01726.x.

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Treatment patterns in migraine patients with cardiovascular risk factors are largely unknown. A retrospective observational study was conducted to characterize the baseline cardiovascular risk profile of new users of specific abortive migraine drugs, and to investigate treatment choices and patterns in patients with and without a known cardiovascular risk profile. New users of a triptan, ergotamine or Migrafin® ( n = 36 839) from 1 January 1990 to 31 December 2006 were included. Approximately 90 of all new users did not have a clinically recognized cardiovascular risk profile. The percentage o

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Gaddam, Soni, and Satyanarayana S. V. Padi. "Gepants, calcitonin gene-related peptide antagonists, for abortive treatment of migraine: current status." International Journal of Basic & Clinical Pharmacology 10, no. 9 (2021): 1156. http://dx.doi.org/10.18203/2319-2003.ijbcp20213373.

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Migraine is a neurovascular disorder characterized by unilateral, recurrent, pulsating, throbbing, and moderate to severe headache. Triptans use is often limited by their poor efficacy, reports of poor responders, and contraindicated in patients with cardiovascular disorders. Calcitonin gene-related peptide (CGRP), a neuropeptide, regulates vascular tonicity as well as potent pain mediator, and both the mechanisms involved in development of migraine headache. Gepants are non-peptide, small molecules, highly selective, and potent CGRP antagonists. These novel drugs have been approved for aborti

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Alland, Lucas, and Solomon H. Jacobson. "QSAR Modeling and Prediction of Triptan Binding Affinities." International Journal of Quantitative Structure-Property Relationships 6, no. 2 (2021): 19–28. http://dx.doi.org/10.4018/ijqspr.2021040102.

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The purpose of this study was to use quantitative structure-activity relationships (QSARs) to identify new triptan molecules that selectively bind to h 5-HT1B and h 5-HT1D to a greater extent than to the similar h 5-HT1A receptor in order to identify novel compounds that could lead to an alternative and potentially superior migraine relief drug. Due to its possibility in migraine abortive properties, binding affinities to h 5-HT1F were also modeled. Binding affinities for 12 different triptan drugs and structurally similar substances were compiled from the literature, and descriptors were gene

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Rahimtoola, H., H. Buurma, CC Tijssen, HG Leufkens, and ACG Egberts. "Migraine Prophylactic Medication Usage Patterns in the Netherlands." Cephalalgia 23, no. 4 (2003): 293–301. http://dx.doi.org/10.1046/j.1468-2982.2003.00494.x.

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This study aims to investigate usage patterns of specific migraine prophylactic medications in ergotamine and triptan patients commencing this treatment for the first time during 1 January 1992 until 31 December 1998. Usage patterns of specific migraine prophylactic drugs were evaluated for each patient by accessing data from a large prescription database and were characterized as continued, switch or stop use during the patient observation period. Several patient and medication-related factors were explored in order to identify a possible relationship with the specific usage pattern defined.

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Askonas, L. J., J. W. Ricigliano та T. M. Penning. "The kinetic mechanism catalysed by homogeneous rat liver 3α-hydroxysteroid dehydrogenase. Evidence for binary and ternary dead-end complexes containing non-steroidal anti-inflammatory drugs". Biochemical Journal 278, № 3 (1991): 835–41. http://dx.doi.org/10.1042/bj2780835.

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Rat liver 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD) (EC 1.1.1.50) is an NAD(P)(+)-dependent oxidoreductase that is potently inhibited at its active site by non-steroidal anti-inflammatory drugs (NSAIDs). Initial-velocity and product-inhibition studies performed in either direction at pH 7.0 are consistent with a sequential ordered Bi Bi mechanism in which pyridine nucleotide binds first and leaves last. This mechanism is supported by fluorescence titrations of the E-NADH complex, and by the failure to detect the binding of either [3H]androsterone or [3H]androstanedione to free enzyme

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Benoliel, Rafael, Yair Sharav, Shimrit Heiliczer, and Yaron Haviv. "Orofacial Migraine and Neurovascular Orofacial Pain: Response to Treatment—A Pilot Study." Biomedicines 13, no. 3 (2025): 714. https://doi.org/10.3390/biomedicines13030714.

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Introduction: The International Classification of Orofacial Pain (ICOP) recognizes orofacial migraine (OFM) and neurovascular orofacial pain (NVOP) as migraine-related entities affecting the facial and oral regions. The diagnostic features of OFM and NVOP indicate that there are many similarities between the two. However, we recently demonstrated that NVOP and OFM are two distinct diagnostic entities, confirming the ICOP classification. It was the aim of the present study to examine whether OFM and NVOP differ in response to pharmacotherapy. Materials and Methods: The cohort was made up of 40

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Silberstein, SD. "Preventive Treatment of Migraine." Cephalalgia 17, no. 2 (1997): 67–72. http://dx.doi.org/10.1046/j.1468-2982.1997.1702067.x.

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The pharmacologic treatment of migraine may be acute (abortive, symptomatic) or preventive (prophylactic). Most migraine preventive medications were designed to treat other disorders (e.g., propranolol for hypertension, valproate for epilepsy, etc.). Preventive medication is usually given daily for months or years; however, treatment can be episodic, subacute, or chronic. The medications can be divided into two major categories: (i) Alternatives of high efficacy, which include β- blockers, tricyclic antidepressants, and divalproex, and of lower efficacy, which include selective serotonin reupt

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Ossei, P. P. S., A. Appiah-Kubi, F. Ankobea-Kokroe, et al. "The Culture of Herbal Preparations Among Pregnant Women: A Remedy or a Suicide Potion? A Case Report and Mini Review." Case Reports in Pathology 2020 (March 12, 2020): 1–6. http://dx.doi.org/10.1155/2020/6186147.

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In general, use of herbal remedies and preparations is on the ascendency in recent times among the general population and especially in young pregnant women, and this may be very dangerous due to adverse effects and interactions with drugs. A survey by the World Health Organization revealed that 70–80% of the world population resort to nonconventional medicines especially, herbal medicines in their primary healthcare. A lot of work has been done on the positive effects of herbs on the human body but very few publications on the potential side effects of consuming crude herbal preparations espe

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Rahimtoola, H., ACG Egberts, H. Buurma, CC Tijssen, and HG Leufkens. "Patterns of Ergotamine and Sumatriptan Use in the Netherlands from 1991 to 1997." Cephalalgia 21, no. 5 (2001): 596–603. http://dx.doi.org/10.1046/j.1468-2982.2001.00212.x.

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The objective of this study was to assess usage patterns of ergotamine and sumatriptan over a period of 6 years, primarily to evaluate the impact that sumatriptan has had on the prescription of ergotamine. This study used ergotamine and sumatriptan prescription data representing inhabitants of eight cities in the Netherlands and covering the period of 1991–1997. The yearly incidence of new users between 1991 and 1997 was estimated for both drugs as well as for the drug of first choice to be prescribed to patients initiating specific abortive migraine treatment with either ergotamine or sumatri

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Vennard, Christopher S., Samson Marvellous Oladeji, and Herman O. Sintim. "Inhibitors of Cyclic Dinucleotide Phosphodiesterases and Cyclic Oligonucleotide Ring Nucleases as Potential Drugs for Various Diseases." Cells 14, no. 9 (2025): 663. https://doi.org/10.3390/cells14090663.

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The phosphodiester linkage is found in DNA, RNA and many signaling molecules, such as cyclic mononucleotide, cyclic dinucleotides (CDNs) and cyclic oligonucleotides (cONs). Enzymes that cleave the phosphodiester linkage (nucleases and phosphodiesterases) play important roles in cell persistence and fitness and have therefore become targets for various diseased states. While various inhibitors have been developed for nucleases and cyclic mononucleotide phosphodiesterases, and some have become clinical successes, there is a paucity of inhibitors of the recently discovered phosphodiesterases or r

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Shardina, K. Yu, S. A. Zamorina, M. B. Raev, and V. A. Chereshnev. "APPLICATION OF ALPHA-FETOPROTEIN IN IMMUNOPHARMACOLOGY – BACKGROUND." Вестник Пермского университета. Серия «Биология»=Bulletin of Perm University. Biology, no. 2 (2020): 145–53. http://dx.doi.org/10.17072/1994-9952-2020-2-145-153.

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The immunopharmacological potential of alpha-fetoprotein (AFP) is closely related to its ability to modulate the activity of cells of the immune system. Due to the immunomodulating properties, as well as the transport function - the transfer of low molecular weight substances, AFP is used in the treatment of a number of pathological conditions. The first attempts to use the therapeutic potential of AFP are associated with the use of extracts of embryonic tissues, with the development of technology, purified AFP from abortive material was used as a drug, and in some cases, recombinant forms of

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Prakash, Sanjay, Harsh Patel, and Chetsi Sudhir Shah. "Medication-overuse headache overlapping with serotonin syndrome." BMJ Case Reports 17, no. 1 (2024): e256464. http://dx.doi.org/10.1136/bcr-2023-256464.

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Serotonin syndrome (SS) is an iatrogenic, drug-induced clinical syndrome caused by an increase in the intrasynaptic concentration of serotonin. Serotonin plays a significant role in the pathophysiology of migraines. Upregulation of 5-HT2A receptors is found in medication-overuse headache (MOH). Several migraine medications, both preventative and abortive drugs, act on serotonin receptors. We report two patients with chronic migraine who developed MOH. Besides headache, patients had frequent attacks of dizziness, restlessness, irritability, insomnia, excessive sweating, abdominal discomforts an

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Oliveira, Arão Belitardo, Eduardo Almeida Guimarães Nogueira, and Mario Fernando Prieto Peres. "Migraine Preventive Treatment Failure: A Cross-Sectional Study in a Tertiary Center in Brazil." Headache Medicine 14, no. 4 (2023): 221–29. http://dx.doi.org/10.48208/headachemed.2023.39.

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BackgroundIn Brazil, there is a scarcity of evidence on migraine burden in patients who have experienced previous preventive treatment failure (PPTF). ObjectiveTo evaluate the associations between ≥ 3 PPTF and clinical, psychiatric, and medical history data.MethodsIn a retrospective, cross-sectional study, the medical records of migraine patients who first visited a tertiary specialized clinic were examined. We selected adults of both sexes aged ≥ 18 who attended their first appointment between March and July 2017. Ordinal logistic regression models estimated the associations between number of

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Ramos, Alexander B., Roberto A. Cruz, Nicole R. Villemarette-Pittman, Piotr W. Olejniczak, and Edward C. Mader. "Dexamethasone as Abortive Treatment for Refractory Seizures or Status Epilepticus in the Inpatient Setting." Journal of Investigative Medicine High Impact Case Reports 7 (January 2019): 232470961984881. http://dx.doi.org/10.1177/2324709619848816.

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Refractory seizures or status epilepticus (RS/SE) continues to be a challenge in the inpatient setting. Failure to abort a seizure with antiepileptic drugs (AEDs) may lead to intubation and treatment with general anesthesia exposing patients to complications, extending hospitalization, and increasing the cost of care. Studies have shown a key role of inflammatory mediators in seizure generation and termination. We describe 4 patients with RS/SE that was aborted when dexamethasone was added to conventional AEDs: a 61-year-old female with temporal lobe epilepsy who presented with delirium, nonco

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Dell’Isola, Giovanni Battista, Eleonora Tulli, Rossella Sica, et al. "The Vitamin D Role in Preventing Primary Headache in Adult and Pediatric Population." Journal of Clinical Medicine 10, no. 24 (2021): 5983. http://dx.doi.org/10.3390/jcm10245983.

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Headache is among the main neurological disorders with a great impact on both adults and children. The diagnosis of primary headache and proper management is often delayed with a great impact on work productivity and overall quality of life. Chronic headache often requires prophylactic therapy to reduce the frequency and severity of the attacks and the use of abortive medications. Besides the use of several classes of drugs, another treatment modality is the use of Nutraceuticals. Some studies have suggested a possible role of vitamin D in headache prophylaxis. Indeed, vitamin D is involved in

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Pearson, Rachel, Desiree Levyim, Meeryo Choe, Sharief Taraman, and Raquel Langdon. "Survey of Child Neurologists on Management of Pediatric Post-traumatic Headache." Journal of Child Neurology 34, no. 12 (2019): 739–47. http://dx.doi.org/10.1177/0883073819856837.

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Traumatic brain injury causes significant morbidity in youth, and headache is the most common postconcussive symptom. No established guidelines exist for pediatric post-traumatic headache management. We aimed to characterize common clinical practices of child neurologists. Of 95 practitioners who completed our survey, most evaluate <50 pediatric concussion patients per year, and 38.9% of practitioners consistently use International Classification of Headache Disorders criteria to diagnose post-traumatic headache. Most recommend nonsteroidal anti-inflammatory drugs as abortive therapy, thoug

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Nandar Kurniawan, Shahdevi, and Dyah Kusuma Wardhani. "CLASSICAL MIGRAINE." JPHV (Journal of Pain, Vertigo and Headache) 3, no. 2 (2022): 35–40. http://dx.doi.org/10.21776/ub.jphv.2022.003.02.2.

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A classic migraine is a recurrent attack of visual, sensory, or other central nervous system symptoms that are unilateral and last several minutes, followed or not followed by a migraine attack. Migraine commonly occurs in 19% of women and 11% of men worldwide, with 20% of sufferers experiencing classic migraine. The etiopathophysiology of classical migraine is not known with certainty, but vascular, neurological, and genetic dysfunction are suspected to be the cause. Classical migraine pathophysiology is associated with the theory of cortical spreading depression, which can explain the proces

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Kalanuria, A. A., and B. L. Peterlin. "A Review of the Pharmacokinetics, Pharmacodynamics and Efficacy of Zolmitriptan in the Acute Abortive Treatment of Migraine." Clinical Medicine. Therapeutics 1 (January 2009): CMT.S2056. http://dx.doi.org/10.4137/cmt.s2056.

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Migraine is a common and often disabling neurovascular disorder. Changes in the metabolism and the central processing of serotonin, as well as abnormalities in the modulation of the central and peripheral trigeminal nociceptive pathways, have been shown to play significant roles in migraine pathophysiology. Recent evidence suggests that a low serotonin state facilitates activation of the trigeminal nociceptive pathways. In addition, several pharmacological agents that modulate serotonin are used in the treatment of migraine. Specifically there are seven FDA approved, 5-hydroxytryptamine (5-HT)

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Abdul, Fatima. "Review on Characteristics and Immune Response against the Proteobacterian Acinetobacter baumannii Bouvet & Grimont, 1986." Biological and Applied Environmental Research 6, no. 2 (2022): 144–61. http://dx.doi.org/10.51304/baer.2022.6.2.144.

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The main cause of death remains infectious diseases, especially in many countries, due for example to the emergence of large numbers of microbial strains that are resistant to many drugs and the increase of new infectious diseases. The previous problem is mostly caused by Gram-negative bacteria. For example, Acinetobacter baumannii resistance to drug plays a serious role in the abortive treatment of infectious diseases and cancer. So, to improve effective treatment in contradiction of A. baumannii, it is vital to know the origin of bacterial host interfaces, particularly those related to the h

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Baldwin, Chris E., Rogier W. Sanders, Yiqun Deng, et al. "Emergence of a Drug-Dependent Human Immunodeficiency Virus Type 1 Variant during Therapy with the T20 Fusion Inhibitor." Journal of Virology 78, no. 22 (2004): 12428–37. http://dx.doi.org/10.1128/jvi.78.22.12428-12437.2004.

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ABSTRACT The fusion inhibitor T20 belongs to a new class of anti-human immunodeficiency virus type 1 (HIV-1) drugs designed to block entry of the virus into the host cell. However, the success of T20 has met with the inevitable emergence of drug-resistant HIV-1 variants. We describe an evolutionary pathway taken by HIV-1 to escape from the selective pressure of T20 in a treated patient. Besides the appearance of T20-resistant variants, we report for the first time the emergence of drug-dependent viruses with mutations in both the HR1 and HR2 domains of envelope glycoprotein 41. We propose a me

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Ożarowski, Marcin, Przemysław Ł. Mikołajczak, Radosław Kujawski, et al. "Pharmacological Effect of Quercetin in Hypertension and Its Potential Application in Pregnancy-Induced Hypertension: Review of In Vitro, In Vivo, and Clinical Studies." Evidence-Based Complementary and Alternative Medicine 2018 (December 2, 2018): 1–19. http://dx.doi.org/10.1155/2018/7421489.

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Since improving maternal and child health is a public health priority worldwide, the main aim of treatment of hypertension in pregnant women is to prevent complications during pregnancy, labor, and postpartum. In consequence, much attention is paid to the use of antihypertensive drugs that can be used safely during pregnancy. Several side effects of methyldopa, which is currently the most commonly used antihypertensive drug in pregnant women, mean that the search for an effective and safe alternative still continues. Flavonoid compounds present in medicinal plants, vegetables, and fruits may b

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Ya.F., Kutasevych, Oliinyk I.O., and Mashtakova I.O. "HERPESVIRUS INFECTION. OPTIMIZATION OF LOCAL TREATMENT." Dermatology and Venerology, no. 4 (2023): 17–20. http://dx.doi.org/10.33743/2308-1066-2023-4-17-20.

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Considering the numerous clinical manifestations of herpes infection, the long recurrent course of the disease and the lifelong persistence of the virus in the body, its treatment is difficult and not always effective. Now none of the known antiviral drugs is able to eliminate the virus from the human body. The goal – to increase the effectiveness of therapy for patients with herpes virus infection by using an antiviral cream containing menthol. Materials and methods. 33 people suffering from herpes virus infection were under observation. Of these, 19 people had herpes zoster, 14 had HSV, 8 ha

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40

Manorenj, Sandhya. "Acute migraine: an overview." International Journal Of Community Medicine And Public Health 12, no. 4 (2025): 1952–64. https://doi.org/10.18203/2394-6040.ijcmph20250952.

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Migraine is a primary headache disorder that affects people of all ages. It is the second most common type of headache disorder after tension headache. Migraine headache usually begins in adolescence, peak in the third decade of life, and becomes less frequent and less severe in later decades. Migraine affects women three times more often than men. Migraine can be very debilitating and can significantly impair an individual's ability to perform daily activities. Creating a clinical review on acute migraine and its management, using a pragmatic approach based on recent advances. The author revi

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Petersen, Mark A., Reshmi Tognatta, Anke Meyer-Franke, et al. "BMP receptor blockade overcomes extrinsic inhibition of remyelination and restores neurovascular homeostasis." Brain 144, no. 8 (2021): 2291–301. http://dx.doi.org/10.1093/brain/awab106.

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Abstract Extrinsic inhibitors at sites of blood–brain barrier disruption and neurovascular damage contribute to remyelination failure in neurological diseases. However, therapies to overcome the extrinsic inhibition of remyelination are not widely available and the dynamics of glial progenitor niche remodelling at sites of neurovascular dysfunction are largely unknown. By integrating in vivo two-photon imaging co-registered with electron microscopy and transcriptomics in chronic neuroinflammatory lesions, we found that oligodendrocyte precursor cells clustered perivascularly at sites of limite

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Fujii, *Kumiko, Masamitsu Maekawa, Shunichiro Tsuji, et al. "DRUG CONCENTRATIONS IN BLOOD AND BREAST MILK WHILE TAKING PSYCHOTROPIC DRUGS-PRELIMINARY STUDY-." International Journal of Neuropsychopharmacology 28, Supplement_1 (2025): i185. https://doi.org/10.1093/ijnp/pyae059.321.

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Abstract Background The perinatal period is a time when psychiatric disorders frequently occur. Promotion of breastfeeding is recommended by WHO and other organizations, and is considered important for mother-infant attachment formation, but expectant mothers taking psychotropic drugs tend to avoid breastfeeding due to less accurate information. Currently, scientific and empirical data on breastfeeding are available, but these data are limited. We report here the results of a study to determine drug concentrations in the blood and breast milk of lactating women taking psychotropic drugs. Aims

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Hallberg, R. L., K. W. Kraus, and E. M. Hallberg. "Induction of acquired thermotolerance in Tetrahymena thermophila: effects of protein synthesis inhibitors." Molecular and Cellular Biology 5, no. 8 (1985): 2061–69. http://dx.doi.org/10.1128/mcb.5.8.2061-2069.1985.

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When Tetrahymena thermophila cells growing at 30 degrees C are shifted to either 40 or 43 degrees C, the kinetics and extent of induction of heat shock mRNAs in both cases are virtually indistinguishable. However, the cells shifted to 40 degrees C show a typical induction of heat shock protein (HSP) synthesis and survive indefinitely (100% after 24 h), whereas those at 43 degrees C show an abortive synthesis of HSPs and die (less than 0.01% survivors) within 1 h. Cells treated at 30 degrees C with the drugs cycloheximide or emetine, at concentrations which are initially inhibitory to protein s

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Hallberg, R. L., K. W. Kraus, and E. M. Hallberg. "Induction of acquired thermotolerance in Tetrahymena thermophila: effects of protein synthesis inhibitors." Molecular and Cellular Biology 5, no. 8 (1985): 2061–69. http://dx.doi.org/10.1128/mcb.5.8.2061.

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When Tetrahymena thermophila cells growing at 30 degrees C are shifted to either 40 or 43 degrees C, the kinetics and extent of induction of heat shock mRNAs in both cases are virtually indistinguishable. However, the cells shifted to 40 degrees C show a typical induction of heat shock protein (HSP) synthesis and survive indefinitely (100% after 24 h), whereas those at 43 degrees C show an abortive synthesis of HSPs and die (less than 0.01% survivors) within 1 h. Cells treated at 30 degrees C with the drugs cycloheximide or emetine, at concentrations which are initially inhibitory to protein s

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Mirza, Babar, and Wageha Akel. "Current Opinion in Pharmacological and Non-Pharmacological Treatment of Migraine: A Focus on Calcitonin Gene-Related Peptide." Neuro – Open Journal 8, no. 1 (2021): 5–10. http://dx.doi.org/10.17140/noj-8-136.

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The most common neurologic disorder is migraines. Migraine is defined as throbbing headaches that can be associated with auras. The headaches are episodic and can be debilitating in quality. Migraines can be triggered by emotional stress, lack of sleep, bright lights, loud noise, certain foods, and other environmental factors. The most effective way of preventing migraines is to avoid these triggers. A migraine can begin with prodromes or warning signs such as loss of vision, loss of motor reflexes or sensation. In this review, the types of migraine, signs and symptoms, pathways leading up to

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Delva, Mykhaylo, Iryna Delva, Victoria Pinchuk, Angelina Kryvchun, and Tetyana Purdenko. "PREVALENCE AND PREDICTORS OF FATIGUE IN PATIENTS WITH EPISODIC MIGRAINE." Wiadomości Lekarskie 75, no. 8 (2022): 1970–74. http://dx.doi.org/10.36740/wlek202208205.

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The aim: We studied prevalence, intensity and predictors of fatigue in patient with episodic migraine (EM). Materials and methods: We enrolled in the study 85 patients with EM and 88 healthy subjects. Fatigue was identified according to Fatigue Severity Scale. We recorded socio-demographic factors: gender, age, marital status, formal education level, employment status, smoking. Anxiety and depression symptoms were assessed by Hospital Anxiety and Depression Scale, daytime sleepiness was measured by Epworth scale. The co-morbidities included history of low back pain during last year, arterial h

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Campos, Janaina K. L., Tiago F. da S. Araújo, Thaíse G. da S. Brito, et al. "Indigofera suffruticosa Mill. (Anil): Plant Profile, Phytochemistry, and Pharmacology Review." Advances in Pharmacological Sciences 2018 (December 2, 2018): 1–6. http://dx.doi.org/10.1155/2018/8168526.

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Indigoferasuffruticosa Mill. (Fabaceae) is known as anil or anileira and also with other names, due to the production of a blue pigment, which is commonly used for yarn dyeing. It is distributed in some states of Brazil (Pernambuco, Paraíba, Mato Grosso, São Paulo, Bahia, Pará, and others) and is used in the popular medicine as a febrifuge, antispasmodic, diuretic, abortive, analgesic, purgative, or soothing agent against stomach and urinary problems, jaundice, and ulcers and also as an insecticide. In addition, I. suffruticosa can be used as animal feed. This review aimed at providing importa

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Karsan, Nazia, and Peter J. Goadsby. "Premonitory-like Symptomatology in Migraine." European Neurological Review 12, no. 01 (2017): 28. http://dx.doi.org/10.17925/enr.2017.12.01.28.

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It has been historically accepted that migraine involves symptomatology outside of head pain. These symptoms can be as equally disabling as the pain, and can include tiredness, concentration impairment, memory impairment and mood change. The symptoms may start before the onset of pain and can persist throughout the headache phase, and even after effective headache treatment into the postdrome. Despite knowledge of these symptoms, their neurobiologic basis and relationship to migraine pain is poorly understood. The fact that these symptoms start early, up to hours to days before the onset of he

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Silva, Nathiely Viana da, Juliana Pradela, Amanda Rodrigues, Roberto Satler Cetlin, Fabiola Dach, and Debora Bevilaqua Grossi. "Profile of childhood headaches in a tertiary center." Headache Medicine 15, no. 3 (2024): 206–13. http://dx.doi.org/10.48208/headachemed.2024.37.

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BackgroundThe aims of this study were to analyze the profile of childhood headache complaints in a tertiary headache center, verify the differences between children and adolescents, and provide the clinical characteristics that are related to the headaches.MethodsA review of 384 medical records of children aged between 4-12 years old (n=206) and adolescents (n=178) aged >12 to 18 years old. The variables evaluated were reported as percentages, compared between children and adolescents and selected the variables that were related to headaches diagnosis.ResultsThe majority of the sample were

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Lai, Conan Hong-Lun, Alex Pak Ki Kwok, and Kwong-Cheong Wong. "Cheminformatic Identification of Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) Inhibitors: A Comparative Study of SMILES-Based Supervised Machine Learning Models." Journal of Personalized Medicine 14, no. 9 (2024): 981. http://dx.doi.org/10.3390/jpm14090981.

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Background: Tyrosyl-DNA phosphodiesterase 1 (Tdp1) repairs damages in DNA induced by abortive topoisomerase 1 activity; however, maintenance of genetic integrity may sustain cellular division of neoplastic cells. It follows that Tdp1-targeting chemical inhibitors could synergize well with existing chemotherapy drugs to deny cancer growth; therefore, identification of Tdp1 inhibitors may advance precision medicine in oncology. Objective: Current computational research efforts focus primarily on molecular docking simulations, though datasets involving three-dimensional molecular structures are o

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