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Journal articles on the topic 'Absolute asymmetric catalysis'

Author: Grafiati

Published: 25 May 2024

Last updated: 19 July 2025

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1

Kaupp, Gerd, and Michael Haak. "Absolute Asymmetric Synthesis by Irradiation of Chiral Crystals." Angewandte Chemie International Edition in English 32, no. 5 (1993): 694–95. http://dx.doi.org/10.1002/anie.199306941.

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2

Lin, Yun-Ming, Zhongtao Li, and Julie Boucau. "Predicting the R/S absolute configuration in asymmetric bifunctional catalysis (ABC)." Tetrahedron Letters 48, no. 30 (2007): 5275–78. http://dx.doi.org/10.1016/j.tetlet.2007.05.131.

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3

Buchcic-Szychowska, Aleksandra, Anna Zawisza, Stanisław Leśniak, and Michał Rachwalski. "Highly Efficient Asymmetric Morita–Baylis–Hillman Reaction Promoted by Chiral Aziridine-Phosphines." Catalysts 12, no. 4 (2022): 394. http://dx.doi.org/10.3390/catal12040394.

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Continuing our research on the use of organophosphorus derivatives of aziridines in asymmetric synthesis and expanding the scope of their applicability, chiral aziridine-phosphines obtained earlier in our laboratory were used as chiral catalysts in the asymmetric Morita–Baylis–Hillman reaction of methyl vinyl ketone and methyl acrylate with various aromatic aldehydes. The desired chiral products were formed in moderate to high chemical yields and with enantiomeric excess reaching value of 98% ee in some cases. The use of catalysts being pairs of enantiomers led to the desired products with opp

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4

Feringa, Ben L., and Richard A. van Delden. "Absolute Asymmetric Synthesis: The Origin, Control, and Amplification of Chirality." Angewandte Chemie International Edition 38, no. 23 (1999): 3418–38. http://dx.doi.org/10.1002/(sici)1521-3773(19991203)38:23<3418::aid-anie3418>3.0.co;2-v.

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5

Barron, L. D. "True and false chirality and absolute asymmetric synthesis." Journal of the American Chemical Society 108, no. 18 (1986): 5539–42. http://dx.doi.org/10.1021/ja00278a029.

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6

Yamamoto, Satoshi, Kenji Matsuda, and Masahiro Irie. "Absolute Asymmetric Photocyclization of a Photochromic Diarylethene Derivative in Single Crystals." Angewandte Chemie International Edition 42, no. 14 (2003): 1636–39. http://dx.doi.org/10.1002/anie.200250417.

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7

Kuhn, Alexander, and Peer Fischer. "Absolute Asymmetric Reduction Based on the Relative Orientation of Achiral Reactants." Angewandte Chemie International Edition 48, no. 37 (2009): 6857–60. http://dx.doi.org/10.1002/anie.200902841.

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8

Bielski, Roman, and Michal Tencer. "Macroscopically chiral system of three independent orientational effects as a condition for absolute asymmetric synthesis." Canadian Journal of Chemistry 81, no. 9 (2003): 1029–37. http://dx.doi.org/10.1139/v03-128.

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The paper introduces the concept of using three independent, macroscopic factors affecting mutual orientation of the reactant molecules to accomplish absolute asymmetric synthesis. Unlike with other methodologies of asymmetric synthesis in physical fields, none of the utilized factors is chiral in itself (as, e.g., circularly polarized light would be), but the combination of the three constitutes a macroscopically chiral influence. Examples of applicable directional factors are time-even vector fields (e.g., electric field and the directional effects of surfaces and interfaces) and the time-od

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9

Wu, Yusheng, Lothar Esser, and Jef K. De Brabander. "Revision of the Absolute Configuration of Salicylihalamide A through Asymmetric Total Synthesis." Angewandte Chemie 39, no. 23 (2000): 4308–10. http://dx.doi.org/10.1002/1521-3773(20001201)39:23<4308::aid-anie4308>3.0.co;2-4.

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10

Kaimori, Yoshiyasu, Yui Hiyoshi, Tsuneomi Kawasaki, Arimasa Matsumoto, and Kenso Soai. "Formation of enantioenriched alkanol with stochastic distribution of enantiomers in the absolute asymmetric synthesis under heterogeneous solid–vapor phase conditions." Chemical Communications 55, no. 36 (2019): 5223–26. http://dx.doi.org/10.1039/c9cc01875a.

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11

Kaupp, Gerd, and Thorsten Marquardt. "Absolute Asymmetric Synthesis Solely under the Influence of a Static Homogeneous Magnetic Field?" Angewandte Chemie International Edition in English 33, no. 14 (1994): 1459–61. http://dx.doi.org/10.1002/anie.199414591.

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12

Maligres, Peter E., Zhiguo Jake Song, Neil A. Strotman, et al. "Synthesis of Fused Oxepane HIV Integrase Inhibitor MK-1376." Synthesis 52, no. 22 (2020): 3378–88. http://dx.doi.org/10.1055/s-0040-1707994.

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Controlling the absolute and relative stereochemistry of a seven-membered oxepane in the formation of HIV integrase inhibitor MK-1376 was accomplished through a strategy involving the use of asymmetric allylation and stereoconvergent, substrate-directed installation of an amine fragment. Surprising reactivity was demonstrated during the asymmetric allylation in which the allyl-pyrimidone product was formed reversibly. The stereoconvergent amine addition was accomplished through an elimination/addition sequence involving a quinone methide reactive intermediate, and nucleophilic trapping of the

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13

Patzer, Michael, Nils Nöthling, Richard Goddard та Christian W. Lehmann. "Absolute Configuration of In Situ Crystallized (+)-γ-Decalactone". Chemistry 3, № 2 (2021): 578–84. http://dx.doi.org/10.3390/chemistry3020040.

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Knowledge about the absolute configuration of small bioactive organic molecules is essential in pharmaceutical research because enantiomers can exhibit considerably different effects on living organisms. X-ray crystallography enables chemists to determine the absolute configuration of an enantiopure compound due to anomalous dispersion. Here, we present the determination of the absolute configuration of the flavoring agent (+)-γ-decalactone, which is liquid under ambient conditions. Single crystals were grown from the liquid in a glass capillary by in situ cryo-crystallization. Diffraction dat

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14

Solladié-Cavallo, A., M. Roje, M. Giraud-Roux, Y. Chen, N. Berova, and V. Sunjic. "Trans-diaryl epoxides: Asymmetric synthesis, ring-opening, and absolute configuration." Chirality 16, no. 3 (2004): 196–203. http://dx.doi.org/10.1002/chir.20005.

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15

Rajegowda, H. R., P. Raghavendra Kumar, Amar Hosamani, and R. J. Butcher. "Synthesis, characterization and determination of absolute structures of palladium complexes of novel chiral acyclic tellurated Schiff base ligands." New Journal of Chemistry 42, no. 8 (2018): 6264–73. http://dx.doi.org/10.1039/c8nj00727f.

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16

Monaco, Guglielmo, Maximilian Tiffner, Antonia Di Mola, Wouter Herrebout, Mario Waser, and Antonio Massa. "Chiral Phase Transfer Catalysis in the Asymmetric Synthesis of a 3,3-Disubstituted Isoindolinone and Determination of Its Absolute Configuration by VCD Spectroscopy." Molecules 25, no. 10 (2020): 2272. http://dx.doi.org/10.3390/molecules25102272.

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In this work we report our endeavors toward the development of an asymmetric synthesis of a 3,3-disubstituted isoindolinone, dimethyl 2-(1-methyl-3-oxoisoindolin-1-yl)malonate, via asymmetric cascade reaction of 2-acetylbenzonitrile with dimethylmalonate and the determination of its absolute configuration (AC) by vibrational circular dichroism (VCD). Bifunctional ammonium salts, derived from trans-1,2-cyclohexanediamine in combination with inorganic bases under phase transfer conditions, were the most effective catalytic systems, leading to the target in high yields and moderate enantioselecti

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17

Castagnetto, Jesus M., Xiaodong Xu, Nina D. Berova, and James W. Canary. "Absolute configurational assignment of self-organizing asymmetric tripodal ligand-metal complexes." Chirality 9, no. 5-6 (1997): 616–22. http://dx.doi.org/10.1002/(sici)1520-636x(1997)9:5/6<616::aid-chir32>3.0.co;2-p.

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18

Gorobets, Evgueni, Masood Parvez, Bronwen MM Wheatley, and Brian A. Keay. "Use of 1H NMR chemical shifts to determine the absolute configuration and enantiomeric purity for enantiomers of 3,3′-disubstituted-MeO-BIPHEP derivatives." Canadian Journal of Chemistry 84, no. 2 (2006): 93–98. http://dx.doi.org/10.1139/v05-230.

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The absolute configuration of a series of 3,3′-disubstituted-MeO-BIPHEP derivatives can be determined by the 1H NMR chemical shift of the methoxyl group when the 3,3′-disubsituted-MeO-BIPHEP derivative is mixed with ()-(2R,3R)-dibenzoyltartaric acid (()-DBTA) (1:2) and its NMR spectrum is run in CDCl3. The chemical shift of the methoxyl group in the Sax enantiomer always occurred at higher field than the corresponding Rax enantiomer. Integration of the corresponding methoxyl signals provides the enantiomeric purity of any mixtures.Key words: assignment of absolute configuration, 2,2′-bis(dip

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19

Charlton, James L., Guy L. Plourde, K. Koh, and Anthony S. Secco. "Asymmetric synthesis of podophyllotoxin analogs." Canadian Journal of Chemistry 68, no. 11 (1990): 2022–27. http://dx.doi.org/10.1139/v90-309.

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Two analogs of podophyllotoxin, with the same absolute stereochemistry as the natural product, have been synthesized from the cycloadduct between α-hydroxy-α′-phenyl-o-quinodimefhane and the fumarate of S-methyl lactate. After initial attempts to produce the cycloadduct from photochemically generated α-hydroxy-α′-phenyl-o-quinodimethane failed, a study of the thermal generation and reaction of α-hydroxy-o-quinodimethane with the fumarate and acrylate of S-methyl lactate was made. A comparison was made of the diastereoselectivity of these cycloaddition reactions to those previously reported, in

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20

Wu, Guanzhao, Yangxue Liu, Zhen Yang, et al. "Multilayer 3D Chirality and Its Synthetic Assembly." Research 2019 (June 27, 2019): 1–11. http://dx.doi.org/10.34133/2019/6717104.

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3D chirality of sandwich type of organic molecules has been discovered. The key element of this chirality is characterized by three layers of structures that are arranged nearly in parallel fashion with one on top and one down from the center plane. Individual enantiomers of these molecules have been fully characterized by spectroscopies with their enantiomeric purity measured by chiral HPLC. The absolute configuration was unambiguously assigned by X-ray diffraction analysis. This is the first multilayer 3D chirality reported and is anticipated to lead to a new research area of asymmetric synt

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21

Tan, Dong‐Xing, Jie Zhou, Chao‐You Liu, and Fu‐She Han. "Enantioselective Total Synthesis and Absolute Configuration Assignment of (+)‐Tronocarpine Enabled by an Asymmetric Michael/Aldol Reaction." Angewandte Chemie International Edition 59, no. 10 (2020): 3834–39. http://dx.doi.org/10.1002/anie.201914868.

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22

Morimoto, Masakazu, Seiya Kobatake, and Masahiro Irie. "Absolute asymmetric photocyclization in chiral diarylethene co-crystals with octafluoronaphthalene." Chem. Commun., no. 3 (2008): 335–37. http://dx.doi.org/10.1039/b713694c.

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23

Hintermann, Lukas, Mauro Perseghini та Antonio Togni. "Development of the titanium–TADDOLate-catalyzed asymmetric fluorination of β-ketoesters". Beilstein Journal of Organic Chemistry 7 (17 жовтня 2011): 1421–35. http://dx.doi.org/10.3762/bjoc.7.166.

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Titanium-based Lewis acids catalyze the α-fluorination of β-ketoesters by electrophilic N–F-fluorinating reagents. Asymmetric catalysis with TADDOLato–titanium(IV) dichloride (TADDOL = α,α,α',α'-tetraaryl-(1,3-dioxolane-4,5-diyl)-dimethanol) Lewis acids produces enantiomerically enriched α-fluorinated β-ketoesters in up to 91% enantiomeric excess, with either F–TEDA (1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)) in acetonitrile solution or NFSI (N-fluorobenzenesulfonimide) in dichloromethane solution as fluorinating reagents. The effects of various reaction p

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24

Wang, Jocelyn, Erica Benedetti, Lucas Bethge, et al. "DNA vs. Mirror-Image DNA: A Universal Approach to Tune the Absolute Configuration in DNA-Based Asymmetric Catalysis." Angewandte Chemie International Edition 52, no. 44 (2013): 11546–49. http://dx.doi.org/10.1002/anie.201306232.

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25

Charlton, James L., Guy L. Plourde та Glenn H. Penner. "Asymmetric induction in Diels–Alder reactions of α-alkoxyorthoquinodimethanes". Canadian Journal of Chemistry 67, № 6 (1989): 1010–14. http://dx.doi.org/10.1139/v89-153.

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It has been shown that dienophiles cycloadd selectively to one face of o-quinodimethanes (o-QDMs) bearing chiral α-alkoxy groups. The face selectivity (diastereoselectivity) increases for the series of chiral groups -OCH(Ph)CH3, -OCH(Ph)CH(CH3)2, and -OCH(Ph)C(CH3)3. A similar effect on the face selectivity of the Diels–Alder reactions of chiral alkoxy vinyl ethers for the same series of chiral groups has been noted previously by others. A mechanism has been proposed to explain the face selectivity in the cycloaddition reactions of the alkoxy o-QDMs. Abinitio molecular orbital calculations wit

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26

Dokli, Irena, Radek Pohl, Blanka Klepetářová, and Ullrich Jahn. "First total synthesis of ent-asperparaline C and assignment of the absolute configuration of asperparaline C." Chemical Communications 55, no. 27 (2019): 3931–34. http://dx.doi.org/10.1039/c9cc00945k.

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27

Wang, Jocelyn, Erica Benedetti, Lucas Bethge, et al. "DNA vs. Mirror-Image DNA: A Universal Approach to Tune the Absolute Configuration in DNA-Based Asymmetric Catalysis." Angewandte Chemie 125, no. 44 (2013): 11760–63. http://dx.doi.org/10.1002/ange.201306232.

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28

Fu, Tai Y., Zhaoqing Liu, John R. Scheffer, and James Trotter. "Supramolecular photochemistry of crystalline host-guest assemblies: absolute asymmetric photorearrangement of the host component." Journal of the American Chemical Society 115, no. 25 (1993): 12202–3. http://dx.doi.org/10.1021/ja00078a084.

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29

Yamamoto, Satoshi, Kenji Matsuda, and Masahiro Irie. "Cover Picture: Absolute Asymmetric Photocyclization of a Photochromic Diarylethene Derivative in Single Crystals (Angew. Chem. Int. Ed. 14/2003)." Angewandte Chemie International Edition 42, no. 14 (2003): 1551. http://dx.doi.org/10.1002/anie.200390373.

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30

Shustov, G. V., S. V. Varlamov, I. I. Chervin, et al. "Asymmetric nitrogen. 72. Geminal systems. 46. N-Chlorooxaziridines: optical activation, absolute configuration, and chiroptical properties." Journal of the American Chemical Society 111, no. 12 (1989): 4210–15. http://dx.doi.org/10.1021/ja00194a009.

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31

Nakai, Hidetaka, Mayu Hatake, Yousuke Miyano, and Kiyoshi Isobe. "The absolute asymmetric photoisomerization of a photochromic dithionite complex in chiral crystals." Chemical Communications, no. 19 (2009): 2685. http://dx.doi.org/10.1039/b901756a.

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32

Cheng, Maosheng, Qiang Li, Bin Lin, et al. "Assignment of the absolute configuration of (−)-linarinic acid by theoretical calculation and asymmetric total synthesis." Tetrahedron: Asymmetry 17, no. 2 (2006): 179–83. http://dx.doi.org/10.1016/j.tetasy.2005.11.029.

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33

Fuglseth, Erik, Eirik Sundby, Per Bruheim, and Bård Helge Hoff. "Asymmetric reduction using (R)-MeCBS and determination of absolute configuration of para-substituted 2-fluoroarylethanols." Tetrahedron: Asymmetry 19, no. 16 (2008): 1941–46. http://dx.doi.org/10.1016/j.tetasy.2008.07.019.

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34

Pinedo-Rivilla, Cristina, Mariana Carrara Cafêu, Josefina Aleu Casatejada, Ângela Regina Araujo, and Isidro G. Collado. "Asymmetric microbial reduction of ketones: absolute configuration of trans-4-ethyl-1-(1S-hydroxyethyl)cyclohexanol." Tetrahedron: Asymmetry 20, no. 23 (2009): 2666–72. http://dx.doi.org/10.1016/j.tetasy.2009.11.001.

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35

Rey, Allan W., Walter A. Szarek та David B. MacLean. "Total synthesis and establishment of the absolute stereochemistry of (+)-mostueine. Addition of chiral nucleophiles to 3,4-dihydro-2-methyl-9-(p-toluenesulfonyl)-β-carbolinium iodide". Canadian Journal of Chemistry 70, № 12 (1992): 2922–28. http://dx.doi.org/10.1139/v92-374.

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A highly convergent synthesis of the pentacyclic indole alkaloid (+)-mostueine (1) is described. The key step involved the coupling of the dianion derived from (1′S)-3-(1′-hydroxyethyl)-4-methylpyridine (4) with the iminium salt 3,4-dihydro-2-methyl-9-(p-toluenesulfonyl)-β-carbolinium iodide (3). Low asymmetric induction (15% de) at the C-1 position of the β-carboline ring system (C-3 of mostueine) was obtained. The nonfermenting baker's yeast-mediated reduction of 3-acetyl-4-methylpyridine provided the hydroxyethylpyridine component in acceptable yield (67%) and high optical purity (99.0% ee)

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36

Bui, Vu P., Minh Nguyen, Jeff Hansen, John Baker, and Tomas Hudlicky. "Enzymatic oxidation of cyclopropylbenzene: structures of new metabolites and possible mechanistic implications." Canadian Journal of Chemistry 80, no. 6 (2002): 708–13. http://dx.doi.org/10.1139/v02-098.

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Cyclopropylbenzene was subjected to whole-cell fermentation with either Escherichia coli JM109 (pDTG601) or E. coli JM109 (pDTG602), expressing toluene dioxygenase and toluene dioxygenase dihydrodiol dehydrogenase enzymes, respectively. The corresponding metabolites, 3-cyclopropylcyclohexa-3,5-diene-1,2-diol (3) and 3-cyclopropylbenzene-1,2-diol (5) have been isolated in yields of 2.5 and 1 g L1, respectively. The absolute stereochemistry correlation for 3 is provided, along with a preliminary discussion of its potential in asymmetric synthesis. Possible mechanistic implications are indicat

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37

Charlton, James L. "Diastereoselectivity and asymmetric induction in the Diels–Alder reaction of o-quinodimethanes." Canadian Journal of Chemistry 64, no. 4 (1986): 720–25. http://dx.doi.org/10.1139/v86-116.

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The extent of asymmetric induction in the bimolecular Diels–Alder reactions of chiral o-quinodimethanes with dimethyl fumarate, methyl acrylate, and maleic anhydride has been studied. o-Quinodimethanes with chiral α-alkoxy groups were prepared from 1-alkoxy-1,3-dihydrobenzo[c]thiophene-2,2-dioxides 4a–f or 1-alkoxy-3-phenyl-1,3-dihydrobenzo[c]thiophene-2,2-dioxides 4g–h by thermolysis. These alkoxybenzosulfones were prepared from the corresponding hydroxybenzosulfones 8 and 1-phenylethanol, 2-phenyl-1-propanol, 4-phenyl-2-butanol, 1-phenyl-2-propanol, 3,3-dimethyl-2-butanol, or 1-cyclo-hexylet

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38

Yamaguchi, Junichiro, Hideaki Kakeya, Takao Uno, Mitsuru Shoji, Hiroyuki Osada, and Yujiro Hayashi. "Determination by Asymmetric Total Synthesis of the Absolute Configuration of Lucilactaene, a Cell-Cycle Inhibitor in p53-Transfected Cancer Cells." Angewandte Chemie International Edition 44, no. 20 (2005): 3110–15. http://dx.doi.org/10.1002/anie.200500060.

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39

Nicolaou, K. C., Jae-Kyu Jung, Won Hyung Yoon, Yun He, Yong-Li Zhong, and Phil S. Baran. "The Absolute Configuration and Asymmetric Total Synthesis of the CP Molecules (CP-263,114 and CP-225,917, Phomoidrides B and A)." Angewandte Chemie International Edition 39, no. 10 (2000): 1829–32. http://dx.doi.org/10.1002/(sici)1521-3773(20000515)39:10<1829::aid-anie1829>3.0.co;2-6.

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40

Baglai, Iaroslav, Michel Leeman, Klaus Wurst, Bernard Kaptein, Richard M. Kellogg, and Willem L. Noorduin. "The Strecker reaction coupled to Viedma ripening: a simple route to highly hindered enantiomerically pure amino acids." Chemical Communications 54, no. 77 (2018): 10832–34. http://dx.doi.org/10.1039/c8cc06658b.

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We introduce a methodology based on a combination of the classical Strecker reaction, simple condensation and Viedma ripening, which allows absolute asymmetric synthesis of highly sterically hindered α-amino acids. As proof-of-principle, enantiomerically pure unnatural α-amino acids tert-leucine and α-(1-adamantyl)glycine have been obtained.

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41

Vaida, M., L. J. W. Shimon, J. Van Mil, et al. "Absolute asymmetric photochemistry using centrosymmetric single crystals. The host/guest system (E)-cinnamamide/E-cinnamic acid." Journal of the American Chemical Society 111, no. 3 (1989): 1029–34. http://dx.doi.org/10.1021/ja00185a036.

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42

Sakamoto, Masami, Shuichiro Kobaru, Takashi Mino, and Tsutomu Fujita. "Absolute asymmetric synthesis by nucleophilic carbonyl addition using chiral crystals of achiral amides." Chem. Commun., no. 8 (2004): 1002–3. http://dx.doi.org/10.1039/b315729f.

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43

Huber, Dominik, and Antonio Mezzetti. "Chiral monodentate phosphoramidite ligands control the absolute configuration at pseudotetrahedral ruthenium: asymmetric catalytic cyclopropanation of olefins." Tetrahedron: Asymmetry 15, no. 14 (2004): 2193–97. http://dx.doi.org/10.1016/j.tetasy.2004.05.040.

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44

Génisson, Yves, Valérie Maraval, Remi Chauvin, et al. "From Natural to Artificial Antitumor Lipidic Alkynylcarbinols: Asymmetric Synthesis, Enzymatic Resolution, and Refined SARs." Synthesis 50, no. 16 (2018): 3114–30. http://dx.doi.org/10.1055/s-0037-1610006.

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Among acetylenic natural products, chiral lipidic alkynylcarbinol (LAC) metabolites, mostly extracted from marine sponges, have revealed a broad spectrum of biological activities, in particular, remarkable antitumor cytotoxicity. With reference to one of the simplest natural representatives, [(S)-eicos-(4E)-en-1-yn-3-ol], and a given cancer cell line (HCT116), combined extensive efforts in chemical synthesis (relying on the use of a large chemical toolbox) and biological analysis (in vitro tests), have provided systematic structure–activity relationships (SARs) where the initially selected fou

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45

McConnell, Oliver, Alvin Bach, Carl Balibar, et al. "Enantiomeric separation and determination of absolute stereochemistry of asymmetric molecules in drug discovery—Building chiral technology toolboxes." Chirality 19, no. 9 (2007): 658–82. http://dx.doi.org/10.1002/chir.20399.

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46

Ohrai, Kazuhiko, Kazuhiro Kondo, Mikiko Sodeoka, and Masakatsu Shibasaki. "Effects of Solvents and Additives in the Asymmetric Heck Reaction of Alkenyl Triflates: Catalytic Asymmetric Synthesis of Decalin Derivatives and Determination of the Absolute Stereochemistry of (+)-Vernolepin." Journal of the American Chemical Society 116, no. 26 (1994): 11737–48. http://dx.doi.org/10.1021/ja00105a014.

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47

Rauk, Arvi, Thomas Eggimann, Helmut Wieser, Gennadii V. Shustov, and Danya Yang. "The vibrational circular dichroism spectra of 2-methylaziridine: dominance of the asymmetric centre at nitrogen." Canadian Journal of Chemistry 72, no. 3 (1994): 506–13. http://dx.doi.org/10.1139/v94-073.

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The experimental VCD spectrum of (2R)-2-methylaziridine has been measured in the region 800–1500 cm−1. The ab initio implementation of the Vibronic Coupling Theory (VCT) of Nafie and Freedman, using the 6-31G*(0.3) basis set, in the common origin and distributed origin gauges and with uniformly and optimally scaled quantum mechanical force fields, is used to investigate the chiroptical properties. VCD spectra are computed for both cis and trans invertomers. The predicted VCD spectrum of 2-methylaziridine (the equilibrium mixture) is dominated by that of the trans diastereomer, not simply becau

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48

Bucciarelli, M., A. Forni, I. Moretti, F. Prati та G. Torre. "Substituent Effect on the Absolute Stereochemistry of the Asymmetric Reduction of Fluorine-Containing β-Diketones by Bakers' Yeast". Biocatalysis 9, № 1-4 (1994): 313–20. http://dx.doi.org/10.3109/10242429408992130.

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49

Roy, René, та Allan W. Rey. "Controlled diastereoselection in 2-lithio-1,3-dithiane additions onto α-substituted γ-lactols. Model studies toward bryostatins from (R)-pantolactone". Canadian Journal of Chemistry 69, № 1 (1991): 62–69. http://dx.doi.org/10.1139/v91-009.

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Homochiral α-substituted γ-lactols 3 and 4 derived from (R)-pantolactone 1 were used in 2-lithio-1,3-dithiane additions to afford very high controls in diastereoselectivities arising from 1,2-asymmetric inductions. Thus non-chelation controlled nucleophilic addition on 3 gave the anti diastereomer 5 as the major product (92% de), while the chelation controlled addition on 4 furnished the syn diastereomer 7 (96% de) as the almost exclusive product. The stereochemical outcomes of these reactions were proven unambiguously by locking the conformation of the syn- and anti-triol adducts 7 and 8 thro

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Cao, Gao, Ai-Xi Hu, and Xin-Rong Xiao. "Asymmetric synthesis, crystal structure, and antidepressant activity of 2-aryl-3-alkyl-5-methyl-2-morpholinol hydrochlorides." Canadian Journal of Chemistry 85, no. 1 (2007): 29–36. http://dx.doi.org/10.1139/v06-184.

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Abstract:

2-Aryl-3-alkyl-5-methyl-2-morpholinols were synthesized from the reactions of chiral 2-aminopropan-1-ol with 2-bromo-1-phenylpropan-1-one, 2-bromo-1-(3-chlorophenyl)propan-1-one, 1-(4-(benzyloxy)phenyl)-2-bromopropan-1-one, 2-bromo-1-(6-methoxy- naphthalen-2-yl)propan-1-one, and 1-(4-(benzyloxy)phenyl)pentan-1-one in N-methyl-2-pyrrolidone (NMP), respectively. The 2-aryl-3-alkyl-5-methyl-2-morpholinols were reacted with hydrogen chloride to give the hydrochloride salts with yields of 56%–77%. The structures of the products were proven by means of their 1H NMR, IR, and MS spectroscopic data. Th

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