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1

Crosland, Maurice. "Assessment by peers in nineteenth-century France: The manuscript reports on candidates for election to the Acad�mie des sciences." Minerva 24, no. 4 (1986): 413–32. http://dx.doi.org/10.1007/bf01096705.

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2

Laouini, D. "Report on the International Symposium on Vaccinology, November 18–20 1998, Paris, France, organized by the Académie des Sciences." Microbes and Infection 1, no. 5 (1999): 361–65. http://dx.doi.org/10.1016/s1286-4579(99)80052-5.

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3

Echavarri-Erasun, Carlos, and Eiko E. Kuramae. "Yeast Genome 10th Anniversary, Académie Royale des Sciences, des Letters et des Beaux-Arts de Belgique in Brussels (Belgium), 7–8 September 2006." FEMS Yeast Research 6, no. 7 (2006): 1103–4. http://dx.doi.org/10.1111/j.1567-1364.2006.00169.x.

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Hall, Kevin. "�tude de la cryoclastie et de l'haloclastie par m�thode dilatom�trique. Ang�lique Prick. M�moire de la Classe des Sciences, 3� s�rie, tome XIX. Acad�mie royale de Belgique, Louvain-la-Neuve, 1999. 311?pp." Permafrost and Periglacial Processes 11, no. 4 (2000): 377. http://dx.doi.org/10.1002/1099-1530(200012)11:4<377::aid-ppp360>3.0.co;2-m.

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5

Konchits, V. V., and E. N. Volnyanko. "50th anniversary of V. A. Belyi Metal-Polymer Research Institute of National Acade-my of Sciences of Belarus." Polymer materials and technologies 5, no. 2 (2019): 87–93. http://dx.doi.org/10.32864/polymmattech-2019-5-2-87-93.

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6

Dyrud, Marilyn A. "An Exploration of Gender Bias in Computer Clip Art." Business Communication Quarterly 60, no. 4 (1997): 30–51. http://dx.doi.org/10.1177/108056999706000402.

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A growing body of literature presenting the results of research regarding text book illustrations indicates that visual gender bias is obvious in several acade mic fields, including business communication. To date, however, no study has extended those observations to clip art files in popular computer programs. The current study examines over 14,000 clip art images for gender bias from six different Windows-based programs: WordPerfect Presentations, PowerPoint 4.0, Microsoft Publisher 2.0, Harvard Graphics 3.0, Power Up!, and Corel 3.0, CD-ROM. Tabulations indicate that only 4.54% of total images depict women and that they are typically presented in stereotypical roles, such as secretaries, nurses, teachers. Reasons include a male bias in the computer science field (a 3:1 ratio in programming), apparent gender-based differences in relationships with machines, and a societal gap in traruitioning between old and new media.
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7

Correll, Denys. "The politics of poverty and social development." International Social Work 51, no. 4 (2008): 453–66. http://dx.doi.org/10.1177/0020872808090239.

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English The Copenhagen World Summit for Social Development established detailed commitments to facilitate social development. In 2000 these commitments were replaced by random and minimalist targets that became known as the Millennium Development Goals. Leading acade mics, policy-makers and the International Council on Social Welfare are seeking to re-establish the commitments made in Copenhagen. French Le sommet mondial de Copenhague pour le développement social établit des engagements détaillés afin de faciliter le développement social. En 2000 ces engagements ont été remplacés par des buts aléatoires et minimalistes devenus connus sous l'appellation d'Objectifs de Développement du Millénaire. Des universitaires importants, des décideurs politiques et le Conseil International de la Protection sociale cherchent à rétablir les engagements pris à Copenhague. Spanish La Cumbre Mundial para el Desarrollo Social, de Copenhague, estableció compromisos detallados para facilitar el desarrollo. En al año 2000, tales compromisos fueron remplazados con objetivos tomados al azar y minimalistas, conocidos como los Objetivos de Desarrollo del Milenio. Líderes académicos, políticos y el Concilio Internacional de Bienestar Social intentan restablecer los compromisos tomados en Copenhague.
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8

Sandeep, S., and A. J. Gasiewski. "Fast Jacobian Mie Library for Terrestrial Hydrometeors." IEEE Transactions on Geoscience and Remote Sensing 50, no. 3 (2012): 747–57. http://dx.doi.org/10.1109/tgrs.2011.2162417.

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9

Monmasson, Eric. "Prof. Okyay Kaynak Receives the Prestigious 2020 TUBA Prize of the Turkish Academy of Sciences [Society News]." IEEE Industrial Electronics Magazine 15, no. 2 (2021): 82–83. http://dx.doi.org/10.1109/mie.2021.3071285.

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10

Holland, John. "Luci mie traditrici by Salvatore Sciarrino (review)." Notes 69, no. 3 (2013): 611–12. http://dx.doi.org/10.1353/not.2013.0041.

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11

Goburdhun, Seema, and Jay Ramsaha. "The Relevance of Social Sciences Teacher Education Programme in Preparing Effective Secondary School Educators." International Journal of Knowledge Society Research 8, no. 2 (2017): 1–12. http://dx.doi.org/10.4018/ijksr.2017040101.

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In Mauritius, the teaching of social studies presents educators with a unique set of challenges, as they are expected to have multi-disciplinary knowledge and multi-dimensional skills to be effective in classrooms. Many of these social studies educators have undertaken the PGCE (Post Graduate Certificate in Education) course offered by the Mauritius Institute of Education (MIE), which is the leading teacher training institute in the country. This paper explores the relevance of the social sciences teacher education programme offered by the MIE in preparing secondary school educators to meet the challenges in their practice in the wake of current curricular reforms. The study used focus group discussions as the main tool to gather in depth views of the participants. Preliminary findings tend to show that although educators may possess skills, lack of mastery in multi-disciplinary knowledge influences their proficiency in classrooms. An analysis of the different modules of the social sciences programme also shows a gap between the educators' needs and the modules offered.
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Baldacchino, Godfrey. "Book Review: Floating islands; a global bibliography, with an edition and translation of G.C. Munz’s Exercitatio acade-mica de insulis natantibus (1711)." Progress in Physical Geography: Earth and Environment 29, no. 1 (2005): 134–35. http://dx.doi.org/10.1177/030913330502900117.

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13

Cheng, Haoyuan, Jinkui Chu, Ran Zhang, Lianbiao Tian, and Xinyuan Gui. "Turbid Underwater Polarization Patterns Considering Multiple Mie Scattering of Suspended Particles." Photogrammetric Engineering & Remote Sensing 86, no. 12 (2020): 737–43. http://dx.doi.org/10.14358/pers.86.12.737.

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It is still unclear how water turbidity affects the underwater polarization pattern. Current simulations only consider single Rayleigh scattering of water molecules and ignore multiple Mie scattering of suspended particles. In this study, a method based on a combination of Monte Carlo numerical simulation and Mie scattering theory is used to establish a model of the turbid underwater polarization distribution. Stokes vector and Mueller matrix are used to simulate the underwater polarization patterns within Snell's window. The distribution patterns and dynamic changes of the simulation are consistent with field measurements. The maximum depth that the polarization pattern can be maintained is calculated for different water types. The influence of water turbidity on polarization patterns is discussed. This model provides a tool for researchers to quantitatively analyze the distribution of turbid underwater polarization. In addition, the study is valuable for remote sensing and marine surveillance.
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Nuraihan Mior Ibrahim, Emma, Nor Laila, and Shafie Mehad. "Trust or distrust in the web‐mediated information environment (W‐MIE)." Journal of Enterprise Information Management 22, no. 5 (2009): 523–47. http://dx.doi.org/10.1108/17410390910993527.

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15

Pan, Xiaolong, Haiyan Wang, Dezhao Zhang, et al. "Microwave Bandpass Filter Based on Mie-Resonance Extraordinary Transmission." PLOS ONE 11, no. 12 (2016): e0166696. http://dx.doi.org/10.1371/journal.pone.0166696.

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16

Molin, Magnus, Maria C. Shoshan, Karin Öhman-Forslund, Stig Linder, and Göran Akusjärvi. "Two Novel Adenovirus Vector Systems Permitting Regulated Protein Expression in Gene Transfer Experiments." Journal of Virology 72, no. 10 (1998): 8358–61. http://dx.doi.org/10.1128/jvi.72.10.8358-8361.1998.

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ABSTRACT Two new adenovirus vector systems based on the tetracycline-regulated Tet-ON- (Gossen, M., et al., Science 268:1766–1769, 1995) and the RU 486-regulated progesterone antagonist (Wang, Y., et al., Proc. Natl. Acad. Sci. USA 91:8180–8184, 1994)-induced gene expression systems are described. We show that both systems permit a tight control of chloramphenicol acetyltransferase reporter gene expression in a variety of cell types, with induction levels of approximately 1,800-fold (Tet-ON system) and 600-fold (RU 486-regulated system), respectively. A significant advantage of our vector systems is that reporter protein expression can be adjusted over a wide range by varying the amount of inducer. The Tet-ON system is also shown to permit an efficient control of reporter gene expression in mice.
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Jaimes Suarez, Oslen Dilayder, and Heriberto Peña-Pedraza. "Mie scattering study of dielectric nanoparticles and nanoantennas applications." Revista de la Academia Colombiana de Ciencias Exactas, Físicas y Naturales 44, no. 173 (2020): 974–83. http://dx.doi.org/10.18257/raccefyn.1265.

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The development of devices for focusing radiation on desired targets is of great importance in different fields of science and communication technologies as it would allow the creation of more efficient optical instruments. In this study, we explored the dispersion of dielectric spherical nanoparticles using elements from Mie’s theory. There was evidence that the form of dispersed radiation patterns depends on factors such as the size of particles and the wavelength of incident radiation. The knowledge regarding radiation dispersion could be applied in the development of nanoantennas, as well as new nanotechnology devices and arrangements.
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Funabiki, Ayako, Shigeko Haruyama, and Hung Thai Dinh. "Holocene evolution of the Kumozu River delta, Mie Prefecture, central Japan." Quaternary Research (Daiyonki-Kenkyu) 49, no. 4 (2010): 201–18. http://dx.doi.org/10.4116/jaqua.49.201.

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19

von Zahn, U., G. von Cossart, J. Fiedler, et al. "The ALOMAR Rayleigh/Mie/Raman lidar: objectives, configuration, and performance." Annales Geophysicae 18, no. 7 (2000): 815–33. http://dx.doi.org/10.1007/s00585-000-0815-2.

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Abstract. We report on the development and current capabilities of the ALOMAR Rayleigh/Mie/Raman lidar. This instrument is one of the core instruments of the international ALOMAR facility, located near Andenes in Norway at 69°N and 16°E. The major task of the instrument is to perform advanced studies of the Arctic middle atmosphere over altitudes between about 15 to 90 km on a climatological basis. These studies address questions about the thermal structure of the Arctic middle atmosphere, the dynamical processes acting therein, and of aerosols in the form of stratospheric background aerosol, polar stratospheric clouds, noctilucent clouds, and injected aerosols of volcanic or anthropogenic origin. Furthermore, the lidar is meant to work together with other remote sensing instruments, both ground- and satellite-based, and with balloon- and rocket-borne instruments performing in situ observations. The instrument is basically a twin lidar, using two independent power lasers and two tiltable receiving telescopes. The power lasers are Nd:YAG lasers emitting at wavelengths 1064, 532, and 355 nm and producing 30 pulses per second each. The power lasers are highly stabilized in both their wavelengths and the directions of their laser beams. The laser beams are emitted into the atmosphere fully coaxial with the line-of-sight of the receiving telescopes. The latter use primary mirrors of 1.8 m diameter and are tiltable within 30° off zenith. Their fields-of-view have 180 µrad angular diameter. Spectral separation, filtering, and detection of the received photons are made on an optical bench which carries, among a multitude of other optical components, three double Fabry-Perot interferometers (two for 532 and one for 355 nm) and one single Fabry-Perot interferometer (for 1064 nm). A number of separate detector channels also allow registration of photons which are produced by rotational-vibrational and rotational Raman scatter on N2 and N2+O2 molecules, respectively. Currently, up to 36 detector channels simultaneously record the photons collected by the telescopes. The internal and external instrument operations are automated so that this very complex instrument can be operated by a single engineer. Currently the lidar is heavily used for measurements of temperature profiles, of cloud particle properties such as their altitude, particle densities and size distributions, and of stratospheric winds. Due to its very effective spectral and spatial filtering, the lidar has unique capabilities to work in full sunlight. Under these conditions it can measure temperatures up to 65 km altitude and determine particle size distributions of overhead noctilucent clouds. Due to its very high mechanical and optical stability, it can also employed efficiently under marginal weather conditions when data on the middle atmosphere can be collected only through small breaks in the tropospheric cloud layers.Key words: Atmospheric composition and structure (aerosols and particles; pressure · density · and temperature; instruments and techniques)
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Huang, Zhiji, Yafang Ma, and Chunbao Li. "Kappa-Carrageenan Inhibited the High-Fat-Diet-Induced Obesity Through Up-Regulating the Hepatic Sirt1 Gene Expression." Current Developments in Nutrition 5, Supplement_2 (2021): 503. http://dx.doi.org/10.1093/cdn/nzab041_018.

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Abstract Objectives Kappa-Carrageenan(CGN) is a widely used food additive in the meat industry and a highly viscous soluble dietary fiber which can hardly be fermented. It has been shown to be able to regulate the energy metabolism and inhibit diet-induced obesity. However, the mechanism is not well understood. The purpose of this study is to investigate the mechanisms of κ-carrageenan to inhibit the body weight gain. Methods A high-fat diet incorporated with lard, pork protein and CGN (2% or 4%, w/w) was given to C57BL/6J mice for 90 days. The energy intake and weight changes were measured every three days. After the dietary intervention, mice were sacrificed, liver and epididymal adipose tissues were taken for real-time polymerase chain reaction (RT-qPCR) analysis. Results The CGN in the high-fat diet restricted weight gain by decreasing liver and adipose mass without inhibiting energy intake. The genes involving energy expenditure such as Acox1, Acadl, CPT-1A and Sirt1 were upregulated in the mice fed with carrageenan. However, the genes responsible for lipid synthesis were not significantly different compared to the diet-induced obese model. Conclusions The anti-obesity effect of the CGN in high-fat diet could be highly related to the enhancement of energy expenditure through up-regulating the downstream genes which promote β-oxidation by increasing the Sirt1 gene expression in liver. Funding Sources Ministry of Science and Technology of the People's Republic of China (10000 Talent Project)
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Liu, Zhi, Limei Li, Hui Li, and Liang Mei. "Preliminary Studies on Atmospheric Monitoring by Employing a Portable Unmanned Mie-Scattering Scheimpflug Lidar System." Remote Sensing 11, no. 7 (2019): 837. http://dx.doi.org/10.3390/rs11070837.

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A portable unmanned Mie-scattering Scheimpflug lidar system has been designed and implemented for atmospheric remote sensing. The Scheimpflug lidar system employs a continuous-wave high-power 808 nm laser diode as the light source and the emitted laser beam is collimated by an F6 lens with a 100 mm aperture. Atmospheric backscattering light is collected by a F5 lens with a 150 mm aperture and then detected by a 45° tilted image sensor. The separation between the transmitting and the receiving optics is about 756 mm to satisfy the Scheimpflug principle. Unmanned outdoor atmospheric measurements were performed in an urban area to investigate system performance. Localized emissions can be identified by performing horizontal scanning measurements over the urban atmosphere for 107° approximately every 17 min. The temporal variation of the vertical aerosol structure in the boundary layer has also been studied through zenith scanning measurements. The promising result shows great potential of the present portable lidar system for unmanned atmospheric pollution monitoring in urban areas.
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Lu, Xiaoman, Xiaoyang Zhang, Fangjun Li, Mark A. Cochrane, and Pubu Ciren. "Detection of Fire Smoke Plumes Based on Aerosol Scattering Using VIIRS Data over Global Fire-Prone Regions." Remote Sensing 13, no. 2 (2021): 196. http://dx.doi.org/10.3390/rs13020196.

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Smoke from fires significantly influences climate, weather, and human health. Fire smoke is traditionally detected using an aerosol index calculated from spectral contrast changes. However, such methods usually miss thin smoke plumes. It also remains challenging to accurately separate smoke plumes from dust, clouds, and bright surfaces. To improve smoke plume detections, this paper presents a new scattering-based smoke detection algorithm (SSDA) depending mainly on visible and infrared imaging radiometer suite (VIIRS) blue and green bands. The SSDA is established based on the theory of Mie scattering that occurs when the diameter of an atmospheric particulate is similar to the wavelength of the scattered light. Thus, smoke commonly causes Mie scattering in VIIRS blue and green bands because of the close correspondence between smoke particulate diameters and the blue/green band wavelengths. For developing the SSDA, training samples were selected from global fire-prone regions in North America, South America, Africa, Indonesia, Siberia, and Australia. The SSDA performance was evaluated against the VIIRS aerosol detection product and smoke detections from the ultraviolet aerosol index using manually labeled fire smoke plumes as a benchmark. Results show that the SSDA smoke detections are superior to existing products due chiefly to the improved ability of the algorithm to detect thin smoke and separate fire smoke from other surface types. Moreover, the SSDA smoke distribution pattern exhibits a high spatial correlation with the global fire density map, suggesting that SSDA is capable of detecting smoke plumes of fires in near real-time across the globe.
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Lu, Xiaoman, Xiaoyang Zhang, Fangjun Li, Mark A. Cochrane, and Pubu Ciren. "Detection of Fire Smoke Plumes Based on Aerosol Scattering Using VIIRS Data over Global Fire-Prone Regions." Remote Sensing 13, no. 2 (2021): 196. http://dx.doi.org/10.3390/rs13020196.

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Smoke from fires significantly influences climate, weather, and human health. Fire smoke is traditionally detected using an aerosol index calculated from spectral contrast changes. However, such methods usually miss thin smoke plumes. It also remains challenging to accurately separate smoke plumes from dust, clouds, and bright surfaces. To improve smoke plume detections, this paper presents a new scattering-based smoke detection algorithm (SSDA) depending mainly on visible and infrared imaging radiometer suite (VIIRS) blue and green bands. The SSDA is established based on the theory of Mie scattering that occurs when the diameter of an atmospheric particulate is similar to the wavelength of the scattered light. Thus, smoke commonly causes Mie scattering in VIIRS blue and green bands because of the close correspondence between smoke particulate diameters and the blue/green band wavelengths. For developing the SSDA, training samples were selected from global fire-prone regions in North America, South America, Africa, Indonesia, Siberia, and Australia. The SSDA performance was evaluated against the VIIRS aerosol detection product and smoke detections from the ultraviolet aerosol index using manually labeled fire smoke plumes as a benchmark. Results show that the SSDA smoke detections are superior to existing products due chiefly to the improved ability of the algorithm to detect thin smoke and separate fire smoke from other surface types. Moreover, the SSDA smoke distribution pattern exhibits a high spatial correlation with the global fire density map, suggesting that SSDA is capable of detecting smoke plumes of fires in near real-time across the globe.
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24

Tomkins, Matt D., Jason M. Dortch, Philip D. Hughes, et al. "Rapid age assessment of glacial landforms in the Pyrenees using Schmidt hammer exposure dating (SHED)." Quaternary Research 90, no. 1 (2018): 26–37. http://dx.doi.org/10.1017/qua.2018.12.

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AbstractSchmidt hammer (SH) sampling of 54 10Be-dated granite surfaces from the Pyrenees reveals a clear relationship between exposure and weathering through time (n=52, R2=0.96, P<0.01) and permits the use of the SH as a numerical dating tool. To test this 10Be-SH calibration curve, 100 surfaces were sampled from five ice-front positions in the Têt catchment, eastern Pyrenees, with results verified against independent 10Be and 14C ages. Gaussian modelling differentiates Holocene (9.4±0.6 ka), Younger Dryas (12.6±0.9 ka), Oldest Dryas (16.1±0.5 ka), last glacial maximum (LGM; 24.8±0.9 ka) and Würmian maximum ice extent stages (MIE; 40.9±1.1 ka). These data confirm comparable glacier lengths during the LGM and MIE (~300 m difference), in contrast to evidence from the western Pyrenees (≥15 km), reflecting the relative influence of Atlantic and Mediterranean climates. Moreover, Pyrenean glaciers advanced significantly during the LGM, with a local maximum at ~25 ka, driven by growth of the Laurentide Ice Sheet, southward advection of the polar front, and a solar radiation minimum in the Northern Hemisphere. This calibration curve is available online (http://shed.earth) to enable wider application of this method throughout the Pyrenees.
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Pawar, Suraj B., Kiran G. Bagul, Yogesh S. Anap, et al. "Minimally Invasive Esophagectomy in Semi-Prone Position (Pawar Technique): Technical Aspects and Outcome in 224 Patients." South Asian Journal of Cancer 09, no. 04 (2020): 213–21. http://dx.doi.org/10.1055/s-0041-1726164.

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Abstract Background and Objectives There are two patient positions described for minimally invasive esophagectomy (MIE) for esophageal cancer, viz., left lateral and prone positions. To retain the benefits and overcome the disadvantages of these positions, a semi-prone position was developed by us. Our objective was to analyze the feasibility of performing MIE in this position. Materials and Methods A retrospective review of patients who underwent MIE at our center from January 2007 to December 2017 was done. A semi-prone position is a left lateral position with an anterior inclination of 45 degrees. Intraoperative parameters including conversion rate, immediate postoperative outcomes, and long-term oncological outcomes were analyzed. Statistical Analysis Statistical Package for the Social Sciences version 19 (IBM SPSS, IBM Corp., Armonk, New York, United States) was utilized for analysis. Survival analysis was done using Kaplan-Meier graph. Quantitative data were described as mean or median with standard deviation, and qualitative data were described as frequency distribution tables. Results Consecutive 224 patients with good performance status were included. After excluding those who required conversion (14 [6.6%]), 210 patients were further analyzed. Median age was 60 years (range: 27–80 years). Neoadjuvant treatment recipients were 160 (76%) patients. Most common presentation was squamous cell carcinoma (146 [70%]) of lower third esophagus (140 [67%]) of stage III (126 [60%]). Median blood loss for thoracoscopic dissection and for total operation was 101.5 mL (range: 30–180 mL) and 286 mL (range: 93–480 mL), respectively. Median operative time for thoracoscopic dissection alone was 67 minutes (range: 34–98 minutes) and for entire procedure was 215 minutes (range: 162–268 minutes). There was no intraoperative mortality. Median 16 lymph nodes were dissected (range: 5–32). Postoperative complication rate and mortality was 50% and 3.3%, respectively. Disease-free interval was 18 months (range: 3–108 months) and overall survival was 22 months (range: 6–108 months). Conclusion MIE with mediastinal lymphadenectomy in a semi-prone position is feasible, convenient, oncologically safe, which can combine the benefits of the two conventional approaches. Further prospective and comparative studies are required to support our findings.
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Iaccarino, Guido, Howard A. Rockman, Kyle F. Shotwell, Eric D. Tomhave, and Walter J. Koch. "Myocardial overexpression of GRK3 in transgenic mice: evidence for in vivo selectivity of GRKs." American Journal of Physiology-Heart and Circulatory Physiology 275, no. 4 (1998): H1298—H1306. http://dx.doi.org/10.1152/ajpheart.1998.275.4.h1298.

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Transgenic mice were generated with cardiac-specific overexpression of the G protein-coupled receptor kinase 3 (GRK3) to explore the in vivo role of this GRK in cardiac function. GRK3 is expressed in the heart along with the β-adrenergic receptor kinase (β-ARK1) and GRK5. We have previously demonstrated that myocardial-targeted overexpression in transgenic mice of β-ARK1 (Koch, W.J., H. A. Rockman, P. Samama, R. A. Hamilton, R. A. Bond, C. A. Milano, and R. J. Lefkowitz. Science 268: 1350–1353, 1995) or GRK5 (Rockman, H.A., D.-J. Choi, N. U. Rahman, S. A. Akhter, R. J. Lefkowitz, and W. J. Koch. Proc. Natl. Acad. Sci. USA 93: 9954–9959, 1996) results in significant attenuation of β-adrenergic signaling and in vivo cardiac function and selective desensitization of angiotensin (ANG) II-mediated cardiac responses. Surprisingly, myocardial overexpression of GRK3 resulted in normal biochemical signaling through β-adrenergic receptors (β-ARs), and in vivo hemodynamic function in response to a β-AR agonist was indistinguishable from that in nontransgenic controls. Furthermore, in vivo signaling and functional responses to ANG II were unaltered. However, myocardial thrombin signaling, as assessed by p42/p44 mitogen-activated protein (MAP) kinase activation, was significantly attenuated in GRK3 transgenic mouse hearts, indicating a distinct in vivo substrate specificity for GRK3.
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Adnan, Nur Adila, Mohd Izuan Effendi Halmi, Siti Salwa Abd Gani, Uswatun Hasanah Zaidan, Radziah Othman, and Mohd Yunus Abd Shukor. "Statistical Modeling for the Optimization of Bioluminescence Production by Newly Isolated Photobacterium sp. NAA-MIE." Proceedings of the National Academy of Sciences, India Section B: Biological Sciences 90, no. 4 (2019): 797–810. http://dx.doi.org/10.1007/s40011-019-01154-1.

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Gabriel, G., M. Abram, B. Keiner, R. Wagner, H. D. Klenk, and J. Stech. "Differential Polymerase Activity in Avian and Mammalian Cells Determines Host Range of Influenza Virus." Journal of Virology 81, no. 17 (2007): 9601–4. http://dx.doi.org/10.1128/jvi.00666-07.

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ABSTRACT As recently shown, mutations in the polymerase genes causing increased polymerase activity in mammalian cells are responsible for the adaptation of the highly pathogenic avian influenza virus SC35 (H7N7) to mice (G. Gabriel et al., Proc. Natl. Acad. Sci. USA 102:18590-18595, 2005). We have now compared mRNA, cRNA, and viral RNA levels of SC35 and its mouse-adapted variant SC35M in avian and mammalian cells. The increase in levels of transcription and replication of SC35M in mammalian cells was linked to a decrease in avian cells. Thus, the efficiency of the viral polymerase is a determinant of both host specificity and pathogenicity.
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Hodnebrog, Ø., T. K. Berntsen, O. Dessens, et al. "Future impact of non-land based traffic emissions on atmospheric ozone and OH – an optimistic scenario and a possible mitigation strategy." Atmospheric Chemistry and Physics 11, no. 21 (2011): 11293–317. http://dx.doi.org/10.5194/acp-11-11293-2011.

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Abstract. The impact of future emissions from aviation and shipping on the atmospheric chemical composition has been estimated using an ensemble of six different atmospheric chemistry models. This study considers an optimistic emission scenario (B1) taking into account e.g. rapid introduction of clean and resource-efficient technologies, and a mitigation option for the aircraft sector (B1 ACARE), assuming further technological improvements. Results from sensitivity simulations, where emissions from each of the transport sectors were reduced by 5%, show that emissions from both aircraft and shipping will have a larger impact on atmospheric ozone and OH in near future (2025; B1) and for longer time horizons (2050; B1) compared to recent time (2000). However, the ozone and OH impact from aircraft can be reduced substantially in 2050 if the technological improvements considered in the B1 ACARE will be achieved. Shipping emissions have the largest impact in the marine boundary layer and their ozone contribution may exceed 4 ppbv (when scaling the response of the 5% emission perturbation to 100% by applying a factor 20) over the North Atlantic Ocean in the future (2050; B1) during northern summer (July). In the zonal mean, ship-induced ozone relative to the background levels may exceed 12% near the surface. Corresponding numbers for OH are 6.0 × 105 molecules cm−3 and 30%, respectively. This large impact on OH from shipping leads to a relative methane lifetime reduction of 3.92 (±0.48) on the global average in 2050 B1 (ensemble mean CH4 lifetime is 8.0 (±1.0) yr), compared to 3.68 (±0.47)% in 2000. Aircraft emissions have about 4 times higher ozone enhancement efficiency (ozone molecules enhanced relative to NOx molecules emitted) than shipping emissions, and the maximum impact is found in the UTLS region. Zonal mean aircraft-induced ozone could reach up to 5 ppbv at northern mid- and high latitudes during future summer (July 2050; B1), while the relative impact peaks during northern winter (January) with a contribution of 4.2%. Although the aviation-induced impact on OH is lower than for shipping, it still causes a reduction in the relative methane lifetime of 1.68 (±0.38)% in 2050 B1. However, for B1 ACARE the perturbation is reduced to 1.17 (±0.28)%, which is lower than the year 2000 estimate of 1.30 (±0.30)%. Based on the fully scaled perturbations we calculate net radiative forcings from the six models taking into account ozone, methane (including stratospheric water vapour), and methane-induced ozone changes. For the B1 scenario, shipping leads to a net cooling with radiative forcings of −28.0 (±5.1) and −30.8 (±4.8) mW m−2 in 2025 and 2050, respectively, due to the large impact on OH and, thereby, methane lifetime reductions. Corresponding values for the aviation sector shows a net warming effect with 3.8 (±6.1) and 1.9 (±6.3) mW m−2, respectively, but with a small net cooling of -0.6 (±4.6) mW m−2 for B1 ACARE in 2050.
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Lhermitte, Roger M. "Observation of rain at vertical incidence with a 94 GHz Doppler radar: An insight on Mie scattering." Geophysical Research Letters 15, no. 10 (1988): 1125–28. http://dx.doi.org/10.1029/gl015i010p01125.

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Tridon, Frédéric, Alessandro Battaglia, and Pavlos Kollias. "Disentangling Mie and attenuation effects in rain using a Ka-W dual-wavelength Doppler spectral ratio technique." Geophysical Research Letters 40, no. 20 (2013): 5548–52. http://dx.doi.org/10.1002/2013gl057454.

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Fiedler, M., H. Frank, T. Gomer, M. Hausmann, K. Pfeilsticker, and U. Platt. "The “Minihole” event on 6. Feb. 1990: Influence of Mie-scattering on the evaluation of spectroscopic measurements." Geophysical Research Letters 20, no. 10 (1993): 959–62. http://dx.doi.org/10.1029/92gl00087.

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33

Fujiwara, Yuki, Toshiaki Irizuki, Hiroki Hayashi, Yuichiro Tanaka, Mayuko Watanabe, and Kenjiro Shimizu. "Stratigraphy and age of the Miocene Awa Group, eastern Iga City, Mie Prefecture, central Japan." Journal of the Geological Society of Japan 111, no. 12 (2005): 779–91. http://dx.doi.org/10.5575/geosoc.111.779.

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Graßl, Sandra, and Christoph Ritter. "Properties of Arctic Aerosol Based on Sun Photometer Long-Term Measurements in Ny-Ålesund, Svalbard." Remote Sensing 11, no. 11 (2019): 1362. http://dx.doi.org/10.3390/rs11111362.

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On the basis of sun photometer measurements located at the German-French polar research base AWIPEV in Ny-Ålesund ( 78.923 ° N, 11.928 ° E), Svalbard, long-term changes (2001–2017) of aerosol properties in the European Arctic are analyzed with the main focus on physical aerosol properties like Aerosol Optical Depth (AOD) and the Ångström exponent during the Arctic haze season in spring compared with summer and autumn months. In order to gain more information from the photometer data and to reduce the error of fitting the data to the Ångström law, a new approach with an Ångström exponent, which depends linearly on wavelength, is presented in this paper. With the Mie program of libRadtran, a calculator for long- and short-wave radiation through the Earth’s atmosphere, artificial aerosol size distributions were created to extend the physical understanding of this modified Ångström law. Monthly means of the measured AOD of the years 1994–2017 are presented to analyze long-term changes of aerosol properties and its load. Because photometer data in general have no height information, a comparison with a Lidar located at the same site is presented. The so-obtained data are then compared with the previous Mie calculus. More homogeneous aerosol properties were found during spring and more heterogeneous in summer. To study possible aerosol sources and sinks, five-day back-trajectories were calculated with the FLEXPART model at three different arriving heights at 11 UTC in the village Ny-Ålesund. Besides the pollution pathway of the aerosol into the European Arctic based on the calculated back-trajectories, the influence of the boundary layer parameterized by the lowermost 100 hPa atmospheric layer is analyzed and compared to the measured aerosol load by the photometer in Ny-Ålesund additionally. During spring, the open ocean acts as a sink for aerosols, whereas sea ice clearly reduces their sinks. Hence, trajectories over sea ice are correlated to higher aerosol loads. Thus, both sources and sinks must be considered to understand aerosol occurrences in the Arctic.
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Chang, Wenmo, Kung-Hau Ding, Leung Tsang, and Xiaolan Xu. "Microwave Scattering and Medium Characterization for Terrestrial Snow With QCA–Mie and Bicontinuous Models: Comparison Studies." IEEE Transactions on Geoscience and Remote Sensing 54, no. 6 (2016): 3637–48. http://dx.doi.org/10.1109/tgrs.2016.2522438.

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Maksyutov, Nikolai, Aleksandr Zorov, Vitali Skorokhodov, and Dmitri Mitrofanov. "PRECURSORS AND NUTRITIENT STATUS EFFECT ON THE YIELD OF HARD SPRING WHEAT IN THE URAL ORENBURG ARID STEPPE." Bulletin Samara State Agricultural Academy 5, no. 3 (2020): 11–17. http://dx.doi.org/10.12737/38763.

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The purpose of the research is the yield increase of spring wheat under arid steppe of the Orenburg pre-Urals con-ditions. Stationary long term field experience was laid on the site of the Kuibyshev's experimental production farm located in Orenburg district. Crop rotations and hard spring wheat monocrop have been studied for 30 years. The two-factor experimental design, consisting of four repetitions was developed. The results of long-term stationary studies for 1990-2019 involving five rotations and hard spring wheat monocrop are presented. Weather conditions, the precursor type and nutrient status are the major factors affecting the hard spring wheat yield. The number of hyperarid years when hard spring wheat yield was less than 5 C per 1 ha in the first rotation amounted to 1 year, in the second – 2, in the third and the fourth – 3 years, in the fifth – 5 years. A significant hard spring wheat increase in yield on the basis of fertilized ground over 30 years was noted on weedfree fallow – 6 years, conservation tillage – 10, green manured – 8, winter – 12, corn – 13 and peas – 4 years, monocrop – 10 years. The highest yield of hard spring wheat for five rotations was on weedfree fallow, conservation tillage and green manured areas (average for two nutrient status), respectively, 11.4, 11.4 and 11.6 C per 1 ha, after winter crops – 10.3 C, corn for silage – 9.3 C, peas – 9.0 C and monocrop – 7.7 C per 1 ha. The yield increase from the fertilized ground was obtained within five rotations respectively for these precursors: 0.4, 0.6, 0.6, 1.0, 0.8, 0.3 and 0.9 C from 1 ha. The research was carried out in accordance with the plan for 2020-2021developed by the Federal State Budgetary Scientific Institution «Federal Scientific Center of Biological Systems and Agrotechnologies of the Russian Acade-my of Sciences» (№ 0761-2019-0003).
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Gust, Kurt A., Qing Ji, and Xiao Luo. "Example of Adverse Outcome Pathway Concept Enabling Genome-to-Phenome Discovery in Toxicology." Integrative and Comparative Biology 60, no. 2 (2020): 375–84. http://dx.doi.org/10.1093/icb/icaa064.

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Synopsis The following article represents a mini-review of an intensive 10-year progression of genome-to-phenome (G2P) discovery guided by the adverse outcome pathway (AOP) concept. This example is presented as a means to stimulate crossover of this toxicological concept to enhance G2P discovery within the broader biological sciences community. The case study demonstrates the benefits of the AOP approach for establishing causal linkages across multiple levels of biological organization ultimately linking molecular initiation (often at the genomic scale) to organism-level phenotypes of interest. The case study summarizes a US military effort to identify the mechanism(s) underlying toxicological phenotypes of lethargy and weight loss in response to nitroaromatic munitions exposures, such as 2,4,6-trinitrotoluene. Initial key discoveries are described including the toxicogenomic results that nitrotoluene exposures inhibited expression within the peroxisome proliferator activated receptor α (PPARα) pathway. We channeled the AOP concept to test the hypothesis that inhibition of PPARα signaling in nitrotoluene exposures impacted lipid metabolic processes, thus affecting systemic energy budgets, ultimately resulting in body weight loss. Results from a series of transcriptomic, proteomic, lipidomic, in vitro PPARα nuclear signaling, and PPARα knock-out investigations ultimately supported various facets of this hypothesis. Given these results, we next proceeded to develop a formalized AOP description of PPARα antagonism leading to body weight loss. This AOP was refined through intensive literature review and polished through multiple rounds of peer-review leading to final international acceptance as an Organisation for Economic Cooperation and Development-approved AOP. Briefly, that AOP identifies PPARα antagonist binding as the molecular initiating event (MIE) leading to a series of key events including inhibition of nuclear transactivation for genes controlling lipid metabolism and ketogenesis, inhibition of fatty acid beta-oxidation and ketogenesis dynamics, negative energy budget, and ultimately the adverse outcome (AO) of body-weight loss. Given that the PPARα antagonism MIE represented a reliable indicator of AO progression within the pathway, a phylogenetic analysis was conducted which indicated that PPARα amino acid relatedness generally tracked species relatedness. Additionally, PPARα amino acid relatedness analysis using the Sequence Alignment to Predict Across Species Susceptibility predicted susceptibility to the MIE across vertebrates providing context for AOP extrapolation across species. Overall, we hope this illustrative example of how the AOP concept has benefited toxicology sows a seed within the broader biological sciences community to repurpose the concept to facilitate enhanced G2P discovery in biology.
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Ghia, Emanuela M., Laura Z. Rassenti, Liguang Chen, et al. "ROR1 Negative Chronic Lymphocytic Leukemia (CLL) Have a Distinctive Gene Expression Signature and May Represent an Indolent-Disease Subtype." Blood 126, no. 23 (2015): 2932. http://dx.doi.org/10.1182/blood.v126.23.2932.2932.

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Abstract ROR1 is a type-1 tyrosine kinase-like orphan-receptor that ordinarily is expressed during embryogenesis, but that also is found on leukemia cells of patients (pts) with chronic lymphocytic leukemia (CLL). We identified patients with CLL cells that had negligible expression of ROR1, despite otherwise satisfying all standard criteria for diagnosis of CLL by iwCLL criteria. We performed next-generation-sequencing on the transcriptomes of 12 CLL cases that had negligible expression of ROR1 and 12 cases that expressed levels of ROR1 comparable to that typically observed in CLL. Eight of the 12 ROR1-negative cases expressed unmutated immunoglobulin heavy-chain variable region genes (IGHV) and 4 used mutated IGHV. Similarly, 7 of the 12 ROR1-positive cases used unmutated IGHV and 5 had mutated IGHV. We identified 3,094 genes that were differentially expressed between the ROR1-positive and ROR1-negative samples out of 14,761 protein-coding genes tested (DESeq2, BH-adjusted p < 0.05). Subnetwork analyses revealed 55 subnetworks that were differentially expressed between ROR1-positive and ROR1-negative cases. ROR1-positive CLL cells had higher-level expression of subnetworks associated with protein-kinase activation or proliferation of tumor cells, but lower-level expression of subnetworks associated with induction of apoptosis or RNA degradation and/or processing, than did ROR1-negative CLL cells. ROR1 and AKT1 were included in 7 subnetworks associated with proliferation, hematologic cancer, or inhibition of cell death. Fourteen (25%) of the 55 differentially expressed subnetworks previously were identified as being differentially expressed between ROR1-positve leukemias of ROR1xTCL1 transgenic mice and ROR1-negative leukemias of Eµ-TCL1-transgenic mice (see Widhopf et al, Proc Natl Acad Sci USA, 2014, PMC3896194). Gene-set enrichment analysis (GSEA) of genes encoding proteins involved in targeted signaling pathways in the BIOCARTA and Reactome database revealed that the ROR1+ leukemias had higher expression levels of genes encoding proteins in the AKT pathway than did the ROR1-negative cases. Immunoblot analysis revealed higher levels of activated pAKT relative to total AKT in representative cases of ROR1-positive CLL (8.8 ± 2.8, N = 7) than that detected in ROR1-negative CLL samples (1.0 ± 0.4, N = 4, P<0.01) (the ratios of pAKT/AKT were normalized to the mean ratio observed for ROR1-negative CLL samples); this is comparable to what we observed for ROR1-positive leukemias of ROR1xTCL1 mice, which had higher levels of activated AKT than the ROR1-negative leukemias of Eµ-TCL1 transgenic mice (Widhopf et al, Proc Natl Acad Sci USA, 2014, PMC3896194). Despite the small size of these two cohorts, it is noteworthy that the median time from diagnosis to initial therapy of the 12 patients with ROR1-negative CLL (9.4 years) was significantly longer than that noted for the 12 ROR1-positive CLL cases (2.5 years, (p < 0.01) used in this comparative analysis. In summary, this study describes a potentially new subtype of ROR1-negative CLL that has a distinctive gene expression signature and apparently indolent clinical course. Disclosures Kipps: Pharmacyclics Abbvie Celgene Genentech Astra Zeneca Gilead Sciences: Other: Advisor.
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39

Martina, Y., K. T. Marcucci, S. Cherqui, et al. "Mice Transgenic for a Human Porcine Endogenous Retrovirus Receptor Are Susceptible to Productive Viral Infection." Journal of Virology 80, no. 7 (2006): 3135–46. http://dx.doi.org/10.1128/jvi.80.7.3135-3146.2006.

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ABSTRACT Porcine endogenous retrovirus (PERV) is considered one of the major risks in xenotransplantation. No valid animal model has been established to evaluate the risks associated with PERV transmission to human patients by pig tissue xenotransplantation or to study the potential pathogenesis associated with PERV infection. In previous work we isolated two genes encoding functional human PERV receptors and proved that introduction of these into mouse fibroblasts allowed the normally nonpermissive mouse cells to become productively infected (T. A. Ericsson, Y. Takeuchi, C. Templin, G. Quinn, S. F. Farhadian, J. C. Wood, B. A. Oldmixon, K. M. Suling, J. K. Ishii, Y. Kitagawa, T. Miyazawa, D. R. Salomon, R. A. Weiss, and C. Patience, Proc. Natl. Acad. Sci. USA 100:6759-6764, 2003). In the present study we created mice transgenic for human PERV-A receptor 2 (HuPAR-2). After inoculation of transgenic animals with infectious PERV supernatants, viral DNA and RNA were detected at multiple time points, indicating productive replication. This establishes the role of HuPAR-2 in PERV infection in vivo; in addition, these transgenic mice represent a new model for determining the risk of PERV transmission and potential pathogenesis. These mice also create a unique opportunity to study the immune response to PERV infection and test potential therapeutic or preventative modalities.
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Tang, Yuming, Ruru Deng, Jun Li, et al. "Estimation of Ultrahigh Resolution PM2.5 Mass Concentrations Based on Mie Scattering Theory by Using Landsat8 OLI Images over Pearl River Delta." Remote Sensing 13, no. 13 (2021): 2463. http://dx.doi.org/10.3390/rs13132463.

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The aerosol optical depth (AOD), retrieved by satellites, has been widely used to estimate ground-level PM2.5 mass concentrations, due to its advantage of large-scale spatial continuity. However, it is difficult to obtain urban-scale pollution patterns from the coarse resolution retrieval results (e.g., 1 km, 3 km, or 10 km) at present, and little research has been conducted on PM2.5 mass concentration retrieval from high resolution remote sensing data. In this study, a physical model is proposed based on Mie scattering theory to evaluate the PM2.5 mass concentrations by using Landsat8 Operational Land Imager (OLI) images. First, the Second Simulation of the Satellite Signal in the Solar Spectrum (6S) model (which can simulate the transmission process of solar radiation in the Earth-atmosphere system and calculate the radiance at the top of the atmosphere) is used to build a lookup table to retrieve the AOD of the coast and blue bands based on the improved deep blue (DB) method. Then, the Angstrom formula is used to obtain the AOD of the green and red bands. Second, the dry near-surface AOD of four bands (coast, blue, green, red) is obtained through vertical correction and humidity correction. Third, aerosol particles are divided into four types based on the standard radiation atmosphere (SRA) model, and the optical properties of different aerosol types are analyzed to derive the volume distribution of aerosol particles. Finally, the relationship between the dry near-surface AOD of each band and the volume distribution of four aerosol particles is correlated, based on Mie scattering theory, and a physical model is established between the AOD and PM2.5 mass concentrations. Then, the distribution of PM2.5 mass concentrations is obtained. The retrieval results show that the distribution of AOD and PM2.5 at the urban scale in detail. The AOD results show that a reasonable relationship with a correlation coefficient (R2) of 0.66 and root mean square error (RMSE) of 0.1037 between Landsat8 OLI AOD and MODO4 DB AOD at 550 nm. The PM2.5 retrieval results are compared with the PM2.5 values measured by ground monitoring stations. The RMSEs for a certain day in different years, including 2017, 2018, 2019, and 2020, are 11.9470 μg/m³, 11.9787 μg/m³, 7.4217 μg/m³, and 5.4723 μg/m³, respectively. The total RMSE is 10.0224 μg/m³. The ultrahigh resolution PM2.5 results can provide pollution details at the urban scale and support better decisions on urban atmospheric environmental governance.
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41

Addis, Sisay. "An exploration of quality management practices in the manufacturing industry of Ethiopia." TQM Journal 32, no. 1 (2019): 127–42. http://dx.doi.org/10.1108/tqm-01-2019-0031.

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Purpose Total quality management (TQM) has long been viewed as a strategy to attain business excellence. However, it is relatively a new concept in the context of emerging economies. Particularly, this is far beyond the reality in the context of African countries, in general. The purpose of this paper is to study the current state of TQM implementation in the manufacturing industry of Ethiopia (MIE). The study also focuses on several comparisons, between large and medium companies, and ISO and non-ISO companies with regard to the adoption of TQM practices. Design/methodology/approach The study draws on top- and middle-level managers from sample companies. Data were collected using a structured survey questionnaire. After testing scale reliability and validity, descriptive and factor analysis were used for the data analysis. Findings The findings, in general, indicated that Ethiopian manufacturers have implemented TQM at a moderate level (grand mean value of 2.86 on 0–5 scale). It is revealed that ISO companies are significantly adopted TQM practices than non-ISO companies, whereas no difference was found between large and medium companies. Originality/value Given the importance of understanding TQM and paucity of research on the topic in Ethiopia, the study provides practical insights and groundwork that can guide practitioners to understand the drivers of TQM in the region. Particularly, the study is useful to plan corrective actions on practices that are likely to obstruct TQM implementation in the MIE. Moreover, the study adds to the empirical literature that may yield important insights on TQM for under-researched emerging economies, particularly for the eastern part of Africa, where nations share similar cross-cultural norms, economic, social and ethnic settings.
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Bangia, Tarun. "Study of atmospheric aerosols over the central Himalayan region using a newly developed Mie light detection and ranging system: preliminary results." Journal of Applied Remote Sensing 5, no. 1 (2011): 053521. http://dx.doi.org/10.1117/1.3579158.

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43

Ervik, Åsmund, Andrés Mejía та Erich A. Müller. "Bottled SAFT: A Web App Providing SAFT-γ Mie Force Field Parameters for Thousands of Molecular Fluids". Journal of Chemical Information and Modeling 56, № 9 (2016): 1609–14. http://dx.doi.org/10.1021/acs.jcim.6b00149.

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44

Mori, Yuichi. "Fossils for Cold-adapted Beetles Obtained from the Plio-Pleistocene Tokai Group in Tado-cho, Mie Prefecture, Central Japan." Quaternary Research (Daiyonki-Kenkyu) 35, no. 5 (1996): 373–81. http://dx.doi.org/10.4116/jaqua.35.373.

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45

Kataoka, Kyoko, and Shusaku Yoshikawa. "Fluvial Terrace Deposits along the Suzuka River, Mie Prefecture, Central Japan: Chronology of Terraces Rarely Intercalted with Volcanic Ash." Quaternary Research (Daiyonki-Kenkyu) 36, no. 4 (1997): 263–76. http://dx.doi.org/10.4116/jaqua.36.263.

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46

Nakajima, Kaori, Taku Kawakami, Hirofumi Suzuki, and Katsutoshi Kuroda. "Tomato leaf mold fungus (Passalora fulva) sensitivity to succinate dehydrogenase inhibitor fungicide in Mie Prefecture, Japan." Annual Report of The Kansai Plant Protection Society 63 (May 31, 2021): 67–73. http://dx.doi.org/10.4165/kapps.63.67.

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47

Bloom, Kaitlyn, Anuradha Karunanidhi, Kimimasa Tobita, et al. "ACAD10 protein expression and Neurobehavioral assessment of Acad10-deficient mice." PLOS ONE 15, no. 12 (2020): e0242445. http://dx.doi.org/10.1371/journal.pone.0242445.

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Acyl-CoA dehydrogenase 10 (Acad10)-deficient mice develop impaired glucose tolerance, peripheral insulin resistance, and abnormal weight gain. In addition, they exhibit biochemical features of deficiencies of fatty acid oxidation, such as accumulation of metabolites consistent with abnormal mitochondrial energy metabolism and fasting induced rhabdomyolysis. ACAD10 has significant expression in mouse brain, unlike other acyl-CoA dehydrogenases (ACADs) involved in fatty acid oxidation. The presence of ACAD10 in human tissues was determined using immunohistochemical staining. To characterize the effect of ACAD10 deficiency on the brain, micro-MRI and neurobehavioral evaluations were performed. Acad10-deficient mouse behavior was examined using open field testing and DigiGait analysis for changes in general activity as well as indices of gait, respectively. ACAD10 protein was shown to colocalize to mitochondria and peroxisomes in lung, muscle, kidney, and pancreas human tissue. Acad10-deficient mice demonstrated subtle behavioral abnormalities, which included reduced activity and increased time in the arena perimeter in the open field test. Mutant animals exhibited brake and propulsion metrics similar to those of control animals, which indicates normal balance, stability of gait, and the absence of significant motor impairment. The lack of evidence for motor impairment combined with avoidance of the center of an open field arena and reduced vertical and horizontal exploration are consistent with a phenotype characterized by elevated anxiety. These results implicate ACAD10 function in normal mouse behavior, which suggests a novel role for ACAD10 in brain metabolism.
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Miller, Brent J., Elisabeth Georges-Labouesse, Paul Primakoff та Diana G. Myles. "Normal Fertilization Occurs with Eggs Lacking the Integrin α6β1 and Is Cd9-Dependent". Journal of Cell Biology 149, № 6 (2000): 1289–96. http://dx.doi.org/10.1083/jcb.149.6.1289.

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Previous results, based on inhibition of fertilization by an anti–α6 integrin mAb (GoH3), suggest that the α6β1 integrin on mouse eggs functions as the receptor for sperm (Almeida, E.A., A.P. Huovila, A.E. Sutherland, L.E. Stephens, P.G. Calarco, L.M. Shaw, A.M. Mercurio, A. Sonnenberg, P. Primakoff, D.G. Myles, and J.M. White. 1995. Cell. 81:1095–1104). Because the egg surface tetraspanin CD9 is essential for gamete fusion (Kaji, K., S. Oda, T. Shikano, T. Ohnuki, Y. Uematsu, J. Sakagami, N. Tada, S. Miyazaki, and A. Kudo. 2000. Nat. Genet. 24:279–282; Le Naour, F., E. Rubinstein, C. Jasmin, M. Prenant, and C. Boucheix. 2000. Science. 287:319–321; Miyado, K., G. Yamada, S. Yamada, H. Hasuwa, Y. Nakamura, F. Ryu, K. Suzuki, K. Kosai, K. Inoue, A. Ogura, M. Okabe, and E. Mekada. 2000. Science. 287:321–324) and CD9 is known to associate with integrins, recent models of gamete fusion have posited that egg CD9 acts in association with α6β1 in fusion (Chen, M.S., K.S. Tung, S.A. Coonrod, Y. Takahashi, D. Bigler, A. Chang, Y. Yamashita, P.W. Kincade, J.C. Herr, and J.M. White. 1999. Proc. Natl. Acad. Sci. USA. 96:11830–11835; Kaji, K., S. Oda, T. Shikano, T. Ohnuki, Y. Uematsu, J. Sakagami, N. Tada, S. Miyazaki, and A. Kudo. 2000. Nat. Genet. 24:279–282; Le Naour, F., E. Rubinstein, C. Jasmin, M. Prenant, and C. Boucheix. 2000. Science. 287:319–321; Miyado, K., G. Yamada, S. Yamada, H. Hasuwa, Y. Nakamura, F. Ryu, K. Su- zuki, K. Kosai, K. Inoue, A. Ogura, M. Okabe, and E. Mekada. 2000. Science. 287:321–324). Using eggs from cultured ovaries of mice lacking the α6 integrin subunit, we found that the fertilization rate, fertilization index, and sperm binding were not impaired compared with wild-type or heterozygous controls. Furthermore, a reexamination of antibody inhibition, using an assay that better simulates in vivo fertilization conditions, revealed no inhibition of fusion by the GoH3 mAb. We also found that an anti-CD9 mAb completely blocks sperm fusion with either wild-type eggs or eggs lacking α6β1. Based on these results, we conclude that the α6β1 integrin is not essential for sperm–egg fusion, and we suggest a new model in which CD9 acts by itself, or interacts with egg protein(s) other than α6β1, to function in sperm–egg fusion.
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Jacoby, Meagan A., Herbert W. Virgin, and Samuel H. Speck. "Disruption of the M2 Gene of Murine Gammaherpesvirus 68 Alters Splenic Latency following Intranasal, but Not Intraperitoneal, Inoculation." Journal of Virology 76, no. 4 (2002): 1790–801. http://dx.doi.org/10.1128/jvi.76.4.1790-1801.2002.

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ABSTRACT Infection of mice with murine gammaherpesvirus 68 (γHV68; also referred to as MHV68) provides a tractable small-animal model with which to address the requirements for the establishment and maintenance of gammaherpesvirus infection in vivo. The M2 gene of γHV68 is a latency-associated gene that encodes a protein lacking discernible homology to any known viral or cellular proteins. M2 gene transcripts have been detected in latently infected splenocytes (S. M. Husain, E. J. Usherwood, H. Dyson, C. Coleclough, M. A. Coppola, D. L. Woodland, M. A. Blackman, J. P. Stewart, and J. T. Sample, Proc. Natl. Acad. Sci. USA 96:7508-7513, 1999; H. W. Virgin IV, R. M. Presti, X. Y. Li, C. Liu, and S. H. Speck, J. Virol. 73:2321-2332, 1999) and peritoneal exudate cells (H. W. Virgin IV, R. M. Presti, X. Y. Li, C. Liu, and S. H. Speck, J. Virol. 73:2321-2332, 1999), as well as in a latently γHV68-infected B-lymphoma cell line (S. M. Husain, E. J. Usherwood, H. Dyson, C. Coleclough, M. A. Coppola, D. L. Woodland, M. A. Blackman, J. P. Stewart, and J. T. Sample, Proc. Natl. Acad. Sci. USA 96:7508-7513, 1999). Here we describe the generation of γHV68 mutants with disruptions in the M2 gene. Mutation of the M2 gene did not affect the ability of the virus to replicate in tissue culture, nor did it affect γHV68 virulence in B6.Rag1 deficient mice. However, we found that M2 was differentially required for acute replication in vivo. While mutation of M2 did not affect acute phase of virus replication in the lungs of mice following intranasal inoculation, acute-phase virus replication in the spleen was decreased compared to that of the wild-type and marker rescue viruses following intraperitoneal inoculation. Upon intranasal inoculation, M2 mutant viruses exhibited a significant decrease in the establishment of latency in the spleen on day 16 postinfection, as measured by the frequency of viral genome-positive cells. In addition, M2 mutant viral genome-positive cells reactivated from latency inefficiently compared to wild-type and marker rescue viruses. By day 42 after intranasal inoculation, the frequencies of M2 mutant and wild-type viral genome-positive cells were nearly equivalent and little reactivation was detected from either population. In sharp contrast to the results obtained following intranasal inoculation, after intraperitoneal inoculation, no significant defect was observed in the establishment or reactivation from latency with the M2 mutant viruses. These results indicate that the requirements for the establishment of latency are affected by the route of infection.
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Sandhya, M., S. Sridharan, M. Indira Devi, K. Niranjan, and A. Jayaraman. "A case study of formation and maintenance of a lower stratospheric cirrus cloud over the tropics." Annales Geophysicae 33, no. 5 (2015): 599–608. http://dx.doi.org/10.5194/angeo-33-599-2015.

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Abstract. A rare occurrence of stratospheric cirrus at 18.6 km height persisting for about 5 days during 3–7 March 2014 is inferred from the ground-based Mie lidar observations over Gadanki (13.5° N, 79.2° E) and spaceborne observations. Due to the vertical transport by large updrafts on 3 March in the troposphere, triggered by a potential vorticity intrusion, the water vapour mixing ratio shows an increase around the height of 18.6 km. Relative humidity with respect to ice is ~ 150%, indicating that the cirrus cloud may be formed though homogeneous nucleation of sulfuric acid. The cirrus cloud persists due to the cold anomaly associated with the presence of a 4-day wave.
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