Journal articles: 'Academic Metabolism'

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Urrutia, Raul. "Academic Skills: Focusing." Pancreatology 6, no. 6 (January 2006): III—IV. http://dx.doi.org/10.1159/000099368.

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Au, Nicole. "Childhood obesity and academic performance." Obesity Research & Clinical Practice 7 (December 2013): e47. http://dx.doi.org/10.1016/j.orcp.2013.12.589.

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Nagelberg, Jodi, Robert Hakim, Brad Kimura, Karen C. McCowen, and Shanna Block. "Assessment of Hypercalcemia Management at an Academic Institution." Journal of the Endocrine Society 5, Supplement_1 (May 1, 2021): A255. http://dx.doi.org/10.1210/jendso/bvab048.518.

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Abstract Background: Currently, there is no widely accepted clinical practice guideline for the management of severe hypercalcemia in hospitalized patients. Objective: The purpose of this project was to analyze management of hypercalcemia in hospitalized patients at an academic medical center, then establish and implement a clinical practice guideline for hypercalcemia treatment. Design: Retrospective chart review of all patients admitted for management of hypercalcemia over 37 consecutive months. Setting: Urban academic tertiary referral center Measurements: We examined which calcium- lowering medications were used, how often 2 medications were needed, average time to normocalcemia, incidence of hypocalcemia post treatment, serum phosphorus nadir and serum creatinine peak. We also assessed medication appropriateness (dose and frequency). Results: Seventy-two patients were included; 58 patients with hypercalcemia of malignancy and 14 patients with hypercalcemia of other diagnoses. In the malignancy group the most common treatment was a combination of calcitonin + bisphosphonate (43%), followed by bisphosphonate alone (29%) and calcitonin alone (24%). In the non-malignancy group, calcitonin alone was used in 50%, calcitonin + bisphosphonate in 21% and a bisphosphonate alone in 14%. Denosumab was rarely used in both groups. The median time to normocalcemia was 3.0 days irrespective of diagnostic group. Seventy two percent of the patients with malignancy and 86% of the non-malignancy group achieved normocalcemia. The incidence of hypocalcemia was 21% (12/58) in the malignancy subgroup and 29% (4/14) in the others after treatment. Serum creatinine did not change from baseline to post-treatment in either population. Median serum phosphorus dropped from 2.9 mg/dL to 1.8 mg/dL in the malignancy group and 4.2 mg/dL to 2.1 mg/dL in the non-malignancy group. Only 41% of patients that received calcitonin, were given recommended dose, route, and frequency. Conclusion: Based on the results of this study, a hypercalcemia treatment guideline was developed, highlighting appropriate medication dose and frequency. This guideline recommends zoledronic acid alone for asymptomatic malignancy patients, and in combination with calcitonin for symptomatic patients. In contrast, calcitonin alone is considered first line for non-malignant conditions.

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Shane, Elizabeth J., Sylvia Christakos, Steven R. Goldring, Joseph A. Lorenzo, Karen R. Hasson, Marc K. Drezner, Lawrence G. Raisz, and John A. Eisman. "Biomedical, Academic, and Industry Interaction." Journal of Bone and Mineral Research 21, no. 3 (January 17, 2006): 353. http://dx.doi.org/10.1359/jbmr.060113.

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Ringel, Matthew D., Elizabeth J. Murphy, and Stephen R. Hammes. "Compensation, Productivity, and Other Demographics of Academic Divisions of Endocrinology, Diabetes, and Metabolism." Journal of the Endocrine Society 3, no. 8 (June 7, 2019): 1485–502. http://dx.doi.org/10.1210/js.2019-00095.

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Abstract The landscape for academic endocrinology divisions has continued to evolve rapidly;thus, finding reliable data that can be used as benchmarks has become more difficult. Resources are available for salary and relative value units, with the Association of American Medical Colleges, Medical Group Management Association, and Faculty Practice Solutions Center the most commonly used databases. However, details regarding how these data are collected and what they include are unclear. For example, does the income include bonus and/or incentive payments? How are work relative value units defined (individual rendering vs supervising advanced practitioners or fellows or residents)? How is a clinical full-time equivalent defined? In addition, other important data that would be relevant to running an academic division of endocrinology are not available from these, or any other resources, including support staff numbers and compensation or fellowship funding and training information. Therefore, an unmet need exists for reliable data that divisions can use to help shape their visions and goals. To address this demand, the Association of Endocrine Chiefs and Directors, in collaboration with the Endocrine Society, developed a detailed survey for members to address the financial, productivity, composition, and educational issues that they regularly face. Twenty academic institutions throughout the United States completed in the survey in 2018. In the present report, we have provided the results of the survey and some initial interpretations of the findings. Our hope is that the information presented will prove useful as academic endocrinology divisions continue to evolve.

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Gregg, W., J. Jirjis, and G. W. Garriss. "Experiences With the Academic Chronic Care Collaborative." Clinical Diabetes 25, no. 2 (April 1, 2007): 72–73. http://dx.doi.org/10.2337/diaclin.25.2.72.

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McNally, D. N., A. M. Kenny, and J. A. Smith. "Adherence of academic geriatric practitioners to osteoporosis screening guidelines." Osteoporosis International 18, no. 2 (October 17, 2006): 177–83. http://dx.doi.org/10.1007/s00198-006-0215-x.

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Snyders, Travis, Daniel Chakos, Umang Swami, Emile Latour, Yiyi Chen, Maria Fleseriu, Mohammed Milhem, Yousef Zakharia, and Roula Zahr. "Ipilimumab-induced hypophysitis, a single academic center experience." Pituitary 22, no. 5 (July 20, 2019): 488–96. http://dx.doi.org/10.1007/s11102-019-00978-4.

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González, G., R. Baudrand, M. F. Sepúlveda, N. Vucetich, F. J. Guarda, P. Villanueva, O. Contreras, et al. "Tumor-induced osteomalacia: experience from a South American academic center." Osteoporosis International 28, no. 7 (March 25, 2017): 2187–93. http://dx.doi.org/10.1007/s00198-017-4007-2.

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Benya, Richard V. "Book Reviews: MODERN METHODS IN PROTEIN NUTRITION AND METABOLISM. Ed by Steven Nissen. Academic." Journal of Parenteral and Enteral Nutrition 18, no. 2 (March 1994): 199–200. http://dx.doi.org/10.1177/014860719401800221.

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Urrutia, Raul. "Academic Skills: A Concise Guide to Grant Writing." Pancreatology 7, no. 4 (September 2007): 307–10. http://dx.doi.org/10.1159/000106761.

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Verkman, A. S. "Drug discovery in academia." American Journal of Physiology-Cell Physiology 286, no. 3 (March 2004): C465—C474. http://dx.doi.org/10.1152/ajpcell.00397.2003.

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Drug discovery and development is generally done in the commercial rather than the academic realm. Drug discovery involves target discovery and validation, lead identification by high-throughput screening, and lead optimization by medicinal chemistry. Follow-up preclinical evaluation includes analysis in animal models of compound efficacy and pharmacology (ADME: administration, distribution, metabolism, elimination) and studies of toxicology, specificity, and drug interactions. Notwithstanding the high-cost, labor-intensive, and non-hypothesis-driven aspects of drug discovery, the academic setting has a unique and expanding niche in this important area of investigation. For example, academic drug discovery can focus on targets of limited commercial value, such as third-world and rare diseases, and on the development of research reagents such as high-affinity inhibitors for pharmacological “gene knockout” in animal models (“chemical genetics”). This review describes the practical aspects of the preclinical drug discovery process for academic investigators. The discovery of small molecule inhibitors and activators of the cystic fibrosis transmembrane conductance regulator is presented as an example of an academic drug discovery program that has yielded new compounds for physiology research and clinical development.

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Eisman, John A., and Joseph A. Lorenzo. "Challenges in Science and Academic-Industry Interactions." Journal of Bone and Mineral Research 22, no. 11 (October 1, 2007): 1654–55. http://dx.doi.org/10.1359/jbmr.07090a.

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Salinas, Leopoldo M. Cobos, Fernando Reyes San Martin, Merri Pendergrass, and Dinkar Rupakula. "Time to Reach Glycemic Goal on an Outpatient Academic Endocrinology Clinic." Journal of the Endocrine Society 5, Supplement_1 (May 1, 2021): A479—A480. http://dx.doi.org/10.1210/jendso/bvab048.981.

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Abstract Background: The achievement of the A1C goals in the US did not improve in 2017 compared to 2014. Guidelines for which patients with T2DM to refer to an endocrinologist are not well defined. Furthermore, there is no consensus about how long patients should be followed by an endocrinologist. Experts have recommended referral to an endocrinologist for new diagnosis, acute hyperglycemia, A1C > 7.0, > 8.0 for 6 months, or A1C 1.4 times the upper limit of normal. However, with the current number of board-certified endocrinologists in the US, it would be impossible for patients with those criteria to be seen even once. To determine which patients should be followed by an endocrinologist, it would help to know which patients are most likely to achieve ongoing benefit. To focus on patients that have a higher chance of improvement, it is important to know the average time it would take to reach an individualized A1C goal and focus on patients more likely to improve. Objective: We performed this quality improvement assessment to 1) determine the percentage of patients with T2DM who achieved their individualized A1C goals (Age 18–55: 7.0% +/- .5%, 55–75: 7.5% +/- .5%, >75: 9.0% +/- .5%) at 12 months after their initial endocrinologist visit and 2) compare characteristics of patients who achieved A1C goals by 12 months versus those who did not achieve goals. Material and Methods: We performed a retrospective chart review of patients with T2DM who had an initial visit at an academic endocrinology clinic between 10/1/2017 and 05/31/2018 (N= 48, 52% female, baseline 9.6%, 48% male, baseline [BL] HbA1c 9.9%). Data for 12 months following the initial visit were collected. Results: Following their initial visit, 21/48 (44%, BL A1c 10.3%) were lost to follow-up. Of those with at least one additional visit, 12/27 (44%, BL A1c 11.3%, P<0.05) achieved A1C goal by the 12-month period. Of those, 6/12 (50%, BL A1c 10.3%), 1/12 (8%, BL A1c 9.9%), 4/12 (25%, BL A1c 9.0%), 1/12 (8%, BL A1c 8.8%) achieved goals by 3, 6, 9, and 12 months respectively. Those who did achieve their goals were slightly older (52 +/- 25yrs) than those who did not (50 +/- 12yrs), p< 0.05. No significant differences between those who were lost to follow-up, achieved goals, or who did not achieve goals with respect to gender, insurance coverage, or regimen. However, those who did continued care had a worse A1c of 11.3%. Conclusion: Of patients with T2DM and uncontrolled hyperglycemia presenting to an academic endocrine clinic, nearly half are lost to follow-up after the initial visit. Future efforts should be made to better understand and potentially improve this. Of additional concern, only about half of patients with at least one additional visit achieved their A1C goal after 12 months, and 91% of those achieved their goals by 9 months. Further study will be needed to determine whether patients who are uncontrolled after 9–12 months will have any further benefit from endocrine follow-up.

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Arky, Ronald. "A Productive Example of Industry and Academic Cooperation." Endocrine Practice 15, no. 4 (May 2009): 291. http://dx.doi.org/10.4158/ep09144.co.

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Antshel, Kevin M. "ADHD, learning, and academic performance in phenylketonuria." Molecular Genetics and Metabolism 99 (2010): S52—S58. http://dx.doi.org/10.1016/j.ymgme.2009.09.013.

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Günter, Tuğçe. "Effectiveness of a Problem-Based Learning (PBL) Scenario for Enhancing Academic Achievement of Energy Metabolism." Research in Science Education 50, no. 5 (August 1, 2018): 1713–37. http://dx.doi.org/10.1007/s11165-018-9750-7.

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Urrutia, Raul. "Academic skills: I got my own laboratory! And now … what?" Pancreatology 6, no. 5 (October 2006): III—V. http://dx.doi.org/10.1159/000096073.

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Finn, Kristin E., Myles S. Faith, and Young S. Seo. "School Engagement in Relation to Body Mass Index and School Achievement in a High-School Age Sample." Journal of Obesity 2018 (October 1, 2018): 1–7. http://dx.doi.org/10.1155/2018/3729318.

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Purpose. Research has documented an inverse relationship between body mass index (BMI) and school achievement but has failed to empirically explain it. We tested whether this association among adolescents can be explained in part by student engagement. Methods. A self-report survey about health and school behaviors was completed by 196 high school students; BMI and achievement data were obtained from school records. Three forms of engagement were assessed: behavioral, presenteeism, and affective. Associations of engagement with BMI and achievement were examined, and mediation analyses were conducted. Results. The simple relationship between BMI and achievement was confirmed and demonstrated that BMI was negatively related to academic achievement. Higher BMI was also significantly correlated with lower classroom participation. Mediation tests showed the significant relationship between BMI and achievement was reduced after accounting for behavioral engagement but not affective engagement. Conclusions. These novel findings shed light on why heavier students often experience lower academic achievement. Intervention studies targeting barriers to classroom engagement among overweight and obese youth are needed so that their academic potential is not compromised.

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Pătărlăgeanu, Simona Roxana, Costel Negrei, Mihai Dinu, and Roxana Chiocaru. "Reducing the Carbon Footprint of the Bucharest University of Economic Studies through Green Facades in an Economically Efficient Manner." Sustainability 12, no. 9 (May 6, 2020): 3779. http://dx.doi.org/10.3390/su12093779.

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This paper focuses on the current environmental issues, more specifically the amount of greenhouse gases humanity is being confronted with at the moment. The research was carried out on a niche of the topic, namely on the carbon footprint of public buildings. The concept of a sustainable university is new and insufficiently explored, and as part of the environmental metabolism, it influences anthropic sustainability in a directly proportional manner. This indicator’s monitoring systems reveal how vulnerable humanity is in front of the latency of an unprecedented and inevitable environmental catastrophe. The ecological effects may be mitigated by the academic community through green urban design. The ecological performance can be expressed in an economically efficient manner, which can, at the same time, create a precious channel of communication within the entire academic community though volunteering for sustainability. Moreover, this research has identified several solutions for optimizing the carbon footprint, which do not hinder the necessary economic development. Within the current context, when most economic activities are leading to ecological collapse, sustainability should be reprioritized with the help of the academic society, through the examples offered by applied research. The premises of this research were represented by bibliometric analyses and the results obtained have proven its importance, as well as the importance of certain scenarios involving solutions for improving the metabolism of nature.

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Martinez-Zamora, Marcos D., Pedro L. Valenzuela, Tania Pinto-Escalona, and Óscar Martinez-de-Quel. "The “Fat but Fit” paradox in the academic context: relationship between physical fitness and weight status with adolescents’ academic achievement." International Journal of Obesity 45, no. 1 (September 2, 2020): 95–98. http://dx.doi.org/10.1038/s41366-020-00666-5.

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Frezza, Eldo Ermenegildo, and Matthew Robinson. "Bariatric and Associated Operations in Private and Academic Practices." Obesity Surgery 14, no. 10 (November 1, 2004): 1406–8. http://dx.doi.org/10.1381/0960892042584058.

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AHMAD, Mehrunnisha, Faizan Zaffar KASHOO, Mazen ALQAHTANI, Waqas SAMI, Moattar RIZVI, and Amira BUSHRA. "Relation Between Night Eating Syndrome and Academic Grades Among University Students." Turkish Journal of Endocrinology and Metabolism 23, no. 2 (2019): 85–91. http://dx.doi.org/10.25179/tjem.2018-63015.

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Saidi, Mavadat. "Appraisal Resources in an Academic Genre: English versus Persian Nutrition Research Articles." Journal of Nutrition and Metabolism 2021 (February 25, 2021): 1–8. http://dx.doi.org/10.1155/2021/6659796.

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Academic study writers utilize a specific set of discursive resources backed up by both cultural and professional norms to be endorsed by the intended audience. The current study aimed to investigate if there were any significant differences between English and Persian academic research articles published in peer-reviewed journals in the field of nutrition in light of appraisal theory. To this end, a corpus of 40 English and 40 Persian academic research articles was analyzed in terms of three categories and subcategories of appraisal theory. The results revealed that the authors of both English and Persian research articles included more attitude resources followed by graduation and engagement resources. Furthermore, no significant difference was observed between these two sets of articles in terms of three major appraisal categories. The findings carry pedagogical implications for English for academic purposes courses to provide the academic discourse communities with the required discursive competencies.

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Schlenker, Evelyn Heymann. "From metabolism and behavior to respiratory physiology: an educational and research perspective." Advances in Physiology Education 44, no. 4 (December 1, 2020): 540–44. http://dx.doi.org/10.1152/advan.00047.2020.

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Throughout my academic career, I have been extremely fortunate to have as mentors, teachers, and advisors, remarkable individuals who helped me develop into a competent researcher and passionate teacher. This essay describes a period in my career as a graduate student that was challenging, but also rewarding. I was fortunate to have contact with world-class researchers and teachers, including Drs. Clyde Herried, Leon Fahri, Hermann Rahn, Donald Riggs, Verner Noell, and Barbara Howell. In addition, I attended excellent University of Buffalo Department of Physiology seminars presented by world-renown scientists. Looking back on the experience, allows me to appreciate the large impact they made on my subsequent career in education and research in physiology and neurobiology.

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Kenney, E. L., S. L. Gortmaker, K. K. Davison, and S. Bryn Austin. "The academic penalty for gaining weight: a longitudinal, change-in-change analysis of BMI and perceived academic ability in middle school students." International Journal of Obesity 39, no. 9 (May 18, 2015): 1408–13. http://dx.doi.org/10.1038/ijo.2015.88.

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Turti, Tatyana V., Irina A. Belyaeva, Marina A. Snovskaya, Olga L. Lukoyanova, Elena P. Zimina, Elena A. Bakovich, Zulfiya F. Zokirova, Maria D. Mitish, Ekaterina G. Bokuchava, and Anastasia G. Selivanovа. "Implication of Modern Complementary Foods in Critical Period for Child Health Programming." Pediatric pharmacology 15, no. 3 (July 6, 2018): 270–76. http://dx.doi.org/10.15690/pf.v15i3.1909.

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The current development of medicine and the results of recent large-scale academic research in pediatrics provide the convincing conclusions that the formation of human health begins in the antenatal period of ontogenesis and continues throughout the infancy. The ideas and subsequent academic research on the influence of nutrition during the first thousand days of life on the programming of metabolism and the development of some chronic somatic diseases such as obesity, hypertension, coronary heart disease have become widespread. In addition, at the same period of life immune abnormalities with a predominance of one of the subpopulations, Th1 or Th2, can possibly form in children at risk of developing allergies when immune response is developing. The predominance of the Th2 cytokine profile (hyperproduction of interleukins 4, 5, 13, etc.) suggests the possibility of stable formation of the atopic status in a child afterwards. Consequently, the application of academic knowledge on the health status programming by nutrition during early ontogenesis is an important tool in preventive pediatric practice.

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Al-Awwad, Narmeen Jamal, Hiba Fathi Al-Sayyed, Zeinah Abu Zeinah, and Reema Fayez Tayyem. "Dietary and lifestyle habits among university students at different academic years." Clinical Nutrition ESPEN 44 (August 2021): 236–42. http://dx.doi.org/10.1016/j.clnesp.2021.06.010.

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Jain, R. K., and T. J. Vokes. "African Americans have lower TBS than whites among densitometry patients at a Chicago academic center." Osteoporosis International 28, no. 3 (October 14, 2016): 917–23. http://dx.doi.org/10.1007/s00198-016-3796-z.

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Ooka, Masato, Caitlin Lynch, and Menghang Xia. "Application of In Vitro Metabolism Activation in High-Throughput Screening." International Journal of Molecular Sciences 21, no. 21 (October 31, 2020): 8182. http://dx.doi.org/10.3390/ijms21218182.

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In vitro methods which incorporate metabolic capability into the assays allow us to assess the activity of metabolites from their parent compounds. These methods can be applied into high-throughput screening (HTS) platforms, thereby increasing the speed to identify compounds that become active via the metabolism process. HTS was originally used in the pharmaceutical industry and now is also used in academic settings to evaluate biological activity and/or toxicity of chemicals. Although most chemicals are metabolized in our body, many HTS assays lack the capability to determine compound activity via metabolism. To overcome this problem, several in vitro metabolic methods have been applied to an HTS format. In this review, we describe in vitro metabolism methods and their application in HTS assays, as well as discuss the future perspectives of HTS with metabolic activity. Each in vitro metabolism method has advantages and disadvantages. For instance, the S9 mix has a full set of liver metabolic enzymes, but it displays high cytotoxicity in cell-based assays. In vitro metabolism requires liver fractions or the use of other metabolically capable systems, including primary hepatocytes or recombinant enzymes. Several newly developed in vitro metabolic methods, including HepaRG cells, three-dimensional (3D) cell models, and organ-on-a-chip technology, will also be discussed. These newly developed in vitro metabolism approaches offer significant progress in dissecting biological processes, developing drugs, and making toxicology studies quicker and more efficient.

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Allen, P. I. M., K. A. Batty, C. A. S. Dodd, J. Herbert, C. J. Hugh, G. F. Moore, M. J. Seymour, H. M. Shiers, P. M. Stacey, and S. K. Young. "Dissociation between emotional and endocrine responses preceding an academic examination in male medical students." Journal of Endocrinology 107, no. 2 (November 1985): 163–70. http://dx.doi.org/10.1677/joe.0.1070163.

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ABSTRACT A study was made in 2 consecutive years of the emotional states and morning and afternoon serum levels of prolactin, cortisol and testosterone of male medical students during a 4- to 5-week period preceding a major university examination. 'Distress', 'anxiety' and, to a lesser degree, 'depression' increased during the 2 weeks immediately preceding the examination and were positively correlated with personality anxiety or neuroticism traits. Group means for hormones showed no consistent change over the same period. Neither was there evidence for a correlation between endocrine and emotional changes within individual students during the pre-examination period. A restricted study showed that there were significant increments in cortisol in samples taken during the examination itself. Changes in emotional state before an examination occurred in the absence of equally dramatic changes in levels of the three hormones studied, though this relationship may have altered during the examination itself. This suggests that the factors controlling the two categories of response may relate differently, in some way, to the imminence of this stressful event. J. Endocr. (1985) 107, 163–170

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Pun, Nicole, Amel Arnaout, Christopher Tran, Clare Liddy, and Erin Keely. "Comparing the content of traditional faxed consultations to eConsults within an academic endocrinology clinic." Journal of Clinical & Translational Endocrinology 24 (March 2021): 100260. http://dx.doi.org/10.1016/j.jcte.2021.100260.

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Mason, Edward E. "Acceptance of Surgery for Obesity by Academic Surgeons in North America." Obesity Surgery 6, no. 3 (June 1, 1996): 218–23. http://dx.doi.org/10.1381/096089296765556791.

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RODEMAN, KATHRYN, AMITH RAO, ANNA KONIGSBERG, LYNN ANG, INAS H. THOMAS, SCOTT SOLEIMANPOUR, and JENNIFER J. IYENGAR. "769-P: Diabetes Distress Screening in an Academic Young Adult Diabetes Transition Program." Diabetes 69, Supplement 1 (June 2020): 769—P. http://dx.doi.org/10.2337/db20-769-p.

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Nguyen, Cynthia T., Anna Seto, Robert Rushakoff, and Heidemarie Windham MacMaster. "Pharmacists’ Impact on Glycemic Control Among Surgical Patients at a Large Academic Institution." Clinical Diabetes 34, no. 2 (April 2016): 105–8. http://dx.doi.org/10.2337/diaclin.34.2.105.

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PALERMO, NADINE E., MELANIE GOODBERLET, GRACE CROMWELL, COLLEEN M. SMITH, AMY BILODEAU, PAUL M. SZUMITA, and MARIE E. MCDONNELL. "1200-P: Use of SGLT2 Inhibitors in Hospitalized Patients in an Academic Center." Diabetes 69, Supplement 1 (June 2020): 1200—P. http://dx.doi.org/10.2337/db20-1200-p.

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Huynh, Peter, Andrea Toulouse, and Irl B. Hirsch. "ONE-YEAR TIME ANALYSIS IN AN ACADEMIC DIABETES CLINIC: QUANTIFYING OUR BURDEN." Endocrine Practice 24, no. 5 (May 2018): 489–91. http://dx.doi.org/10.4158/ep-2017-0267.

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Toledo, Frederico G. S., and Andrew F. Stewart. "The Academic and Clinical Endocrinology Physician Workforce in the U.S." Journal of Clinical Endocrinology & Metabolism 96, no. 4 (April 1, 2011): 942–44. http://dx.doi.org/10.1210/jc.2011-0516.

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Weber, Michael A. "Academic Physicians Confront a Hostile World: The Creation of ACRE." Journal of Clinical Hypertension 11, no. 10 (October 2009): 533–36. http://dx.doi.org/10.1111/j.1751-7176.2009.00192.x.

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Giles, Thomas D. "Health Care Reform Requires Renaissance of Flexnerian Academic Medical Centers." Journal of Clinical Hypertension 11, no. 12 (December 2009): 695–97. http://dx.doi.org/10.1111/j.1751-7176.2009.00194.x.

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Probasco, John C., Lilja Solnes, Abhinav Nalluri, Jesse Cohen, Krystyna M. Jones, Elcin Zan, Mehrbod S. Javadi, and Arun Venkatesan. "Decreased occipital lobe metabolism by FDG-PET/CT." Neurology - Neuroimmunology Neuroinflammation 5, no. 1 (November 15, 2017): e413. http://dx.doi.org/10.1212/nxi.0000000000000413.

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Objective:To compare brain metabolism patterns on fluorodeoxyglucose (FDG)-PET/CT in anti–NMDA receptor and other definite autoimmune encephalitis (AE) and to assess how these patterns differ between anti–NMDA receptor neurologic disability groups.Methods:Retrospective review of clinical data and initial dedicated brain FDG-PET/CT studies for neurology inpatients with definite AE, per published consensus criteria, treated at a single academic medical center over a 10-year period. Z-score maps of FDG-PET/CT were made using 3-dimensional stereotactic surface projections in comparison to age group–matched controls. Brain region mean Z scores with magnitudes ≥2.00 were interpreted as significant. Comparisons were made between anti–NMDA receptor and other definite AE patients as well as among patients with anti–NMDA receptor based on modified Rankin Scale (mRS) scores at the time of FDG-PET/CT.Results:The medial occipital lobes were markedly hypometabolic in 6 of 8 patients with anti–NMDA receptor encephalitis and as a group (Z = −4.02, interquartile range [IQR] 2.14) relative to those with definite AE (Z = −2.32, 1.46; p = 0.004). Among patients with anti–NMDA receptor encephalitis, the lateral and medial occipital lobes were markedly hypometabolic for patients with mRS 4–5 (lateral occipital lobe Z = −3.69, IQR 1; medial occipital lobe Z = −4.08, 1) compared with those with mRS 0–3 (lateral occipital lobe Z = −0.83, 2; p < 0.0005; medial occipital lobe Z = −1.07, 2; p = 0.001).Conclusions:Marked medial occipital lobe hypometabolism by dedicated brain FDG-PET/CT may serve as an early biomarker for discriminating anti–NMDA receptor encephalitis from other AE. Resolution of lateral and medial occipital hypometabolism may correlate with improved neurologic status in anti–NMDA receptor encephalitis.

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Bisset, S., M. Fournier, L. Pagani, and M. Janosz. "Predicting academic and cognitive outcomes from weight status trajectories during childhood." International Journal of Obesity 37, no. 1 (July 17, 2012): 154–59. http://dx.doi.org/10.1038/ijo.2012.106.

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Cass, Amanda S., Johlee S. Odinet, John M. Valgus, and Daniel J. Crona. "Infusion reactions following administration of intravenous rolapitant at an academic medical center." Journal of Oncology Pharmacy Practice 25, no. 7 (October 22, 2018): 1776–83. http://dx.doi.org/10.1177/1078155218808084.

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Abstract:

In 2017, due to a fluid shortage secondary to Hurricane Maria's devastation of Puerto Rico, hospitals and health-systems began to substitute rolapitant for fosaprepitant as part of chemotherapy-induced nausea and vomiting prevention and treatment strategies. However, despite advantageous pharmacologic and formulation (e.g. long half-life, quicker time to onset, and lack of first-pass hepatic metabolism) profiles, there seems to be significant risk of infusion-related hypersensitivity reactions associated with the administration of intravenous rolapitant. In January 2018, the U.S. FDA issued a Health Care Provider Letter stating that anaphylaxis, anaphylactic shock, and other serious hypersensitivity reactions have been reported in the postmarketing setting. Importantly, these reactions were observed at a higher rate than initially reported in the phase 1 bioequivalence study that led to FDA approval of intravenous rolapitant (2.8%), with many resulting in hospitalizations. At our institution, rolapitant-induced infusion-related reactions also occurred in more patients than expected (8.7%). Described herein are six cases of infusion-related hypersensitivity reactions with intravenous rolapitant at the North Carolina Cancer Hospital. Due to the quick onset of the infusion-related hypersensitivity reactions with intravenous rolapitant, interpatient differences in pharmacokinetics or pharmacodynamics are unlikely to be the cause. An objective assessment utilizing the Naranjo Causality Scale rates these infusion-related hypersensitivity reactions as definite adverse drug reactions.

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Hendrickson, Chase D., Saumya Saini, Avin Pothuloori, and John N. Mecchella. "ASSESSING REFERRALS AND IMPROVING INFORMATION AVAILABILITY FOR CONSULTATIONS IN AN ACADEMIC ENDOCRINOLOGY CLINIC." Endocrine Practice 23, no. 2 (February 2017): 190–98. http://dx.doi.org/10.4158/ep161514.or.

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Rajab, Hussein. "Abstract #142: Cortisol Level and Academic Stress in Medical Vs Non-Medical Students." Endocrine Practice 23 (April 2017): 25. http://dx.doi.org/10.1016/s1530-891x(20)44316-2.

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Ryan, Christopher M. "A Team Approach to the Child With Diabetes Who Is Having Academic Difficulties." Diabetes Educator 13, no. 1 (January 1987): 58–60. http://dx.doi.org/10.1177/014572178701300112.

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Rudolph, Justen W., and Irl B. Hirsch. "ASSESSMENT OF THERAPY WITH CONTINUOUS SUBCUTANEOUS INSULIN INFUSION IN AN ACADEMIC DIABETES CLINIC." Endocrine Practice 8, no. 6 (November 2002): 401–5. http://dx.doi.org/10.4158/ep.8.6.401.

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Pietras, Sara, Patricia Hanrahan, Lindsay Arnold, Elliot Sternthal, and Marie McDonnell. "State-of-the-Art Inpatient Diabetes Care: The Evolution of an Academic Hospital." Endocrine Practice 16, no. 3 (May 2010): 512–21. http://dx.doi.org/10.4158/ep09319.co.

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Karlin, Nina, Amylou Dueck, and Curtiss Cook. "Cancer with Diabetes: Prevalence, Metabolic Control, and Survival in an Academic Oncology Practice." Endocrine Practice 18, no. 6 (November 2012): 898–905. http://dx.doi.org/10.4158/ep12128.or.

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Kern, F. "Cholesterol metabolism, LDL, and the LDL receptor Edited by N.B. Myant, 465 pp. New York: Academic Press, 1990. $70." Hepatology 13, no. 6 (June 1991): 1262. http://dx.doi.org/10.1016/0270-9139(91)92505-3.

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Journal articles on the topic 'Academic Metabolism'

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