Journal articles: 'Acalypha india'

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Gantala, Srilatha R., Shilpa Kalukuri, Wilcina G. Dommat, et al. "Therapeutic and Biological Aspects of Leaf Extracts from Indian Copper leaf Plant (Acalypha Indica)." INTERNATIONAL JOURNAL OF PLANT AND ENVIRONMENT 9, no. 02 (2023): 150–56. http://dx.doi.org/10.18811/ijpen.v9i02.07.

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Acalypha indica is found extensively in India and the Indian subcontinent. The whole plant has medicinal values with many ethnobotanical importance which has been described in many ancient and modern literatures. Most medicinal and therapeutic capabilities are present in leaves compared to other plant parts such as roots, stems, seeds and flowers. Various studies have been proposed to establish the therapeutic capabilities of the Indian Copper leaf plant (Acalypha indica). This research paper focuses on studying different phytochemicals present in acetone and hydro-alcohol leaf extracts of Acalypha indica with quantification of Phenol and Flavonoid content in the plant extracts. This experimental evidence also quantifies the antioxidant properties by DPPH methodology for given extracts and the plants’ importance as antibacterial and anti-inflammatory activities. The study also gives insight into the capability of the solvent extracts for the greener synthesis of silver nanoparticles (AgNP’s) from molecular silver solution with characterization and morphological characteristics of synthesized silver nanoparticles.

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Estari, Mamidala, and Paindla Prasad. "Phytochemical and Chromatographic Studies in the Leaves Extract of Acalypha Indica." International Interdisciplinary Research Journal 4, no. 1 (2014): 1750182. https://doi.org/10.5281/zenodo.7213379.

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ABSTRACT Acalypha indica is herb found in tropical countries. This plant used traditionally for treats various diseases. In the present study we carried out phytochemical analysis and TLC profiling were performed on different solvent extractions like n-hexane, chloroform, ethyl acetate, acetone and methanol of Acalypha indica leaves extracts. Fresh matured leaves were collected and shade dried. The leaves powder was successively extracted with different solvents. This study involves the preliminary screening of phytochemical and the qualitative thin layer chromatographic separation of secondary metabolites from the leaves of Acalypha indica. TLC profiling of the Acalypha indica was carried out using sequential extracts of solvents with varying polarity; n-hexane, ethyl acetate and acetic acid respectively. Qualitative phytochemical analysis of this plant confirm the presence of various phytochemical like alkaloids, carbohydrates, glycosides, saponins, proteins, tannins, phenols, amino acids, and starch in their leaf extracts. The TLC chromatograms constituted different coloured phytochemical compounds with different Rf values. It can be conveniently used to evaluate the quality of different area samples. For TLC, new solvent system developed for the best separation of the phytoconstituents present in the extracts. KEYWORDS: Acalypha indica, Phytochemicals, TLC, Plant extracts, Retention factor (Rf) References: Amin Mir M, Sawhney S.S, Jassal M M S. (2013), Qualitative and quantitative analysis of phttochemicals of taraxacum officinale.001-005. 2. Bauer RW, Caius JF, Mhaskar KS. (1923). The correlation between chemical composition and antihelmintics and their therapeutic values in connection with the Hookworm. 11:103-110. 3. Bourdy G, Walter A. (1992); Maternity and medicinal plants in Vanuatu. 37:179- 196. Chandra Mohan S., Dinakar S., Anand T., Elayaraja R. And Sathiya priya B., (2012). Phytochemical, GC-MS analysis and Anti bacterial activity of a medicinal plant Acalypha indica, 1050-1054. Chopra RN, Nayar SI, Chopra IC. (1956).Glossary of Indian Medical plants. 6. Chopra R. N., Nayar S. L., Chopra IC. (2006), Glossary of Indian Medicinal Plants, National Institute of Science Communication and Information Resources, page no.54. Das AK Ahmed F, Biswas NN, Dev S, Masud MM.(2005); Diuretic activity of Acalypha indica.4:1-2. De S, Dey Y. N., Ghosh A. K. (2010), Phytochemical investigation and chromatographic evaluation of the different extracts of tuber of Amorphaallus paeonifolius, 150-157. Govindarajan M., Jebanesan A., Reetha D, Amsath. R., Pushpanathan T and Samidurai K. (2008). Anti bacterial activity of Acalypha indica. 12:299-302. 11. Gupta R.K. (2010), Medicinal & Aromatic plants, CBS publishers &distributors116-117. Hiremath SP, Badami S, Swamy HKS, Biradar JS. (1993). Antimicrobial activity of various extracts of Acalypha indica. 33:75-77. John De Britto A, Steena Roshan Sebastian and Mary Sujin, (2011).Phytochemical analysis of medicinal Plants of Lamiaceae, 001-006. 14. Khare C P. Indian medicinal plants, Springer, (2007), Gupta. A. K., N. Tondon, M. Sharma. Quality Standards of Indian Medicinal Plants. 128. 15. Kirtikar K.R, Basu B.D, (2006), Indian Medicinal Plants, International book distributors, 2,856-860.  Lingaiah M and Nagaraja Rao P. An ethnobotanical survey of medicinal plants used by traditional healers of Adilabad district, Andhra Pradesh, India. Biolife. 1(1):17-23, 2013. Manisha Masin, Tanushree Banerjee, Bhasker Banerjee and Anita PAL,(2011).Antidiabetic activity of Acalypha indica on normal and alloxan induced diabetic rats;51-54. Mohana Vamsi N, Venkata Sunil kumar M, Kodandaram N, Padmanbha Reddy Y, (2008).Evalution of anti-inflammatory activity of Acalypha indica. 7:89- 91. Nadkarni K.M. (2009), Indian Materia Medica, Bombay Popular PrakashamVol.1, 285-286. 20. Pongtip Sithisarn et al. (2006); Medicinal Principles Practice 15: 219-222. Prasad Paindla, Rajendra Chary Vijayagiri and Estari Mamidala (2013), Ethnobotanical survey in different mandals of Adilabad district, Andhra Pradesh, India, International Journal of Sciences. 77-82. Prashant Tiwari and Bimlesh kumar, Mandeep kaur, Gurpreet kaur, Harleen kaur (2011), Phytochemical screening and extraction. 98-106. Rajendra Chary Vijayagiri and Estari Mamidala. Preliminary phytochemical and in vitro anti-diabetic activity of Ficus racemosa (L.) stems bark extract. Online International Interdisciplinary Research Journal, Voll-III, Nov 2013. 134-141. Rajendra Prasad Gujjeti and Estari Mamidala. Phytochemical Screening and Thin Layer Chromatographic Studies of Aerva lanata root extract. International Journal of Innovative Research in Science, Engineering and Technology. 2(10), 2013. 5725-5730. Ruchi GM, Majekodunmi, Ramia, Gouri BV, Hussain A, Suad khamis SB. (2007), Antioxidant capacity of some edibile and wound healing plants in Oman. 101:465-470.  Singh DAP, Raman M, Saradha V, Jayabharathi P, Kumar VRS, (2004); Acarcidal Property of kuppaimemeni (Acalypha indica) against natural Psoroptes cuniculi infestion in broiler Rabbits. 74(10):1003-1006. Suresh Reddy J, Rajeswara Rao P, Mada SR.(2002); Wound healing effects of Heliotropium indicum, Plumbago zeylanicum and Acalypha indica in rats. 79:249-251. Wagner H and Bladt S. (2004). Plant drug analysis-A thin layer chromatography atlas, 2nd Ed., 29. Yan-Ling Wang et al. (2010); J Medicinal Plants Research. 4(4): 304-308.

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S., Thuraisingam, Prabagar S., J.Nanthakumar, and Prabagar J. "Evaluation of antimicrobial activity of aqueous extracts of Acalypha indica." INTERNATIONAL JOURNAL OF AGRICULTURE AND BIOLOGICAL SCIENCES 4, March & April 2020 (2020): 155–62. https://doi.org/10.5281/zenodo.3986633.

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Acalypha indica is a small herb which is distributed in most of Asian countries such as Sri Lanka, India, and Pakistan. It is commonly known as Indian Copper leaf and it is used in traditional medicines for bacterial and fungal diseases. Aqueous extraction of plant materials such as leaf and whole plant were investigated for anti-microbial property without changing concentration. Results of this study revealed that all extracts had good inhibitory activity against gram positive and gram negative bacteria. The clear zone for Staphylococcus aureus and Klebsiella were found with the diameter of 1.85cm and 1.9cm respectively, though the inhibitory diameters of these bacteria were smaller than the streptomycin control. Antifungal activity of whole plant and leaf extract of Acalypha indica against all fungal species showed the inhibitory growth less than 20%. The findings exhibit that aqueous extracts have broad spectrum activity and there is a possibility in treatment of infectious diseases.

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Hegde, Dr Guruprasad. "Exploring the Hepatoprotective Activity of Harita Manjari (Acalypha indica.L): Review of an Anukta Dravya." International Journal for Research in Applied Science and Engineering Technology 13, no. 6 (2025): 2147–51. https://doi.org/10.22214/ijraset.2025.72579.

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Ayurveda system is a unique means to maintain health by usingHerbal preparations, Mineral preparation and animal products. Hence the knowledge of plants becomes essential in Ayurveda. InAyurveda system medicinal plants are documented by means of Rasapanchaka and Karma. Chronological upgradation of knowledge on medicinal plants has been observed from Vedic Kala to Samhita Kala and up to Nighantu(lexicon) Kala, in fact during Nighantu period added a great number of valuable exotic as well as folklore plants. India officially recognizes over 3500 plants for their medicinal value. It is generally estimated that over 6000 plants in India are in use for folk, traditional and herbal medicine. Such undocumented or unexplained drugs are known as Anukta Dravya (extra pharmacopeial drugs). Liver disease is the tenth most common cause of death in India as per the World Health Organization. Liver disease affects every one in five Indians; Liver diseases do not usually cause any obvious signs or symptoms until it's advanced and the liver is damaged. Haritha Manjari (Acalypha indica L) belongs to family Euphorbiaceae and is a common weed found in Asia, including India. So, this article aims to Explore the Hepatoprotective activity of Haritha Manjari (Acalypha indica L) - An Anukta dravya

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Prasad, Paindla, and Mamidala Estari. "Inhibition of Human Immunodeficiency Virus (HIV-1) Reverse Transcriptase by Acalypha indica (L.) Plant Leaves Extract." American Journal of Science and Medical Research 8, no. 3 (2022): 1–4. https://doi.org/10.5281/zenodo.7213389.

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ABSTRACT HIV (Human Immunodeficiency Virus) the virus that bases AIDS, is one of the newest zones of medical research nowadays. The objective of the study is to test the HIV-1 reverse transcriptase inhibitory efficiency of Acalypha indica leaves extracts. The leaves of Acalypha indica, were collected from the selected places of Adilabad District. Leaves were exposed to size reduction to get coarse powder and extracted by sequential maceration method using non-polar to polar solvents. Cell viability was determined in contradiction of PBMC cells by the trypan-blue dye exclusion technique and by MTT assay. The HIV reverse transcriptase enzyme inhibition due to each extract was determined by HIV- 1 RT inhibition assay by using of Retro Sys HIV-1 RT activity kit. At 50 µg/mL n-hexane extract presented the uppermost percentage of HIV-1 RT enzyme inhibition (88.26%) followed by methanol (75%), chloroform (67.3%), ethyl acetate (67.3%) and acetone (63.4%). The weak inhibition was establish at 3.125 µg/mL concentration for all extracts, except n-hexane. At this concentration n-hexane displays more than 50% inhibition. The control drug AZT shows highest inhibition (88.26% and 92.6%) at 25 and 50 µg/mL concentrations. These results achieves that n-hexane crude extract taking more effective activity among the other crude extracts. Keywords: Acalypha india, HIV, MTT assay, reverse transcriptase, trypan blue References: Khare VS Singh VP, Sharma SK. Medicinal plants from Ujjain district Madhya Pradesh - part II. Indian Drugs Pharm Ind 1980; 5: 7-12. Gupta K. and P.J. Klasse. (2006). How do viral and host factors modulate the sexual transmission of HIV? Can transmission be blocked? PLoS Med, 3(2): 79.  Kirtikar K.R., Basu B.D., Indian Medicinal Plants, International book distributors, 2006,   (2), 856 -860.   K. M. Nadkarni. Indian Materia Medica, Bombay Popular Prakashan, 2009, Vol.1, 285-    286 R. N. Chopra, S. L. Nayar, I. C. Chpora. Glossary of Indian Medicinal Plants, NationalInstitute of Science Communication and Information Resources, 2006, page no.54-56. S. S. Agarwal, M. Paridhavi, Clinically useful herbal drugs, Ahuja Publishing House, 2005, 281-282. Ben Erik, Van Wyk, Michael Wink, Medicinal Plants of the World, Briza Publications, 2009, page no. 403.   Anazetti MC, Melo PS, Duran N, Haun M (2003). Comparative cytotoxicity dimethylamide-crotonin in the promyelocytic leukemia cell line (HL60) and human peripheral blood mononuclear cells. Toxicology 188: 261-274 Liu CP, Tsai WJ, Lin YL, Liao JF, Chen CF, Kuo YC (2004). The extracts from Nelumbo nucifera suppress cell cycle progression, cytokine genes expression, and cell proliferation in human peripheral blood mononuclear cells. Life Sci. 75: 699-716. Estari Mamidala, & Prasad Paindla. (2013). Ethnobotanical Survey In Different Mandals Of Adilabad District, Andhra Pradesh, India. Dr. Estari Mamidala, Ethnobotanical Survey in Different Mandals of Adilabad District, Andhra Pradesh, India, International Journal of Sciences 01(2013):77-83, 2(1), 77–83. https://doi.org/10.5281/zenodo.7213355  Estari Mamidala, & Prasad Paindla. (2014). Phytochemical and Chromatographic Studies in the Leaves Extract of Acalypha Indica. International Interdisciplinary Research Journal, 4(1), 1750182. https://doi.org/10.5281/zenodo.7213379 WHO, (2014).  Report on the global HIV/AIDS, Epidemic. NACO, (2011).  Annual Report 2010-2011 AVERT, (2011). AIDS Virus Education and Research Trust History of AIDS.

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Setiawaty, Natasya Nadia Poetri, Jindrayani Nyoo Putro, and Shella Permatasari Santoso. "The Effect of Hydrothermal Treatment on the Biological Properties of Anting-Anting (Acalypha indica Linn.) Plant Extract Containing Carbon Dots." Widya Teknik 22, no. 2 (2023): 42–51. http://dx.doi.org/10.33508/wt.v22i1.4854.

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Anting-anting plant (Acalypha indica Linn.) is shrubs that grow as a weed in most parts of tropical countries. The plant has a record of ethno-pharmacological uses by native Asians, the plant has especially been used widely in the therapeutically practice in India. Owing to its rich biological active compounds content, Acalypha indica is rendered as a wild-plants with excellent antioxidant activities. In this work, hydrothermal extraction was performed to obtained liquid products containing high biological active compounds and carbon dots from Acalypha indica plant powder. The effect of hydrothermal temperature of 100, 110, 120, 130, and 140°C was evaluated on the optical properties and biological activity of the resultant liquid products from A. indica. The results imply that the liquid products obtained at highest investigated hydrothermal temperature of 140°C had the highest total phenolic and total flavonoid content, specifically the calculated total phenolic content is 5.50 mg GAE/g and total flavonoid content is 0.53 mg QE/g; that is higher than the non-hydrothermally treated extract. Owing to the high biological active compounds, the liquid products also show high radical scavenging activity, that is 78.5% against DPPH and 47.2% against superoxide radicals. The antibacterial assays show that the liquid product obtained from hydrothermal treatment at 140°C has better activity than the extract, with inhibition rate of 61.1 and 97.2% against Escherichia coli and Staphylococcus aureus, respectively.

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De, Manna, Lata Sharma, and Chandan Kumar Acharya. "A Comprehensive Chemical Characterization of Leaves of Five Potential Medicinal Plants in Paschim Medinipur District, W. B., India." International Journal of Experimental Research and Review 36 (December 30, 2023): 20–36. http://dx.doi.org/10.52756/ijerr.2023.v36.002.

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The physico-chemical and spectroscopic characterization of five selected medicinal plants viz., Acalypha indica, Senna tora, Euphorbia hirta, Physalis angulata and Ziziphus mauritina are the essence and has been carried out to assess bioactive potential and to establish traditional belief in the light of scientific interpretation. Fresh leaves were collected from Paschim Medinipur district of West Bengal, India, dried and powdered for Proximate analysis, ultimate analysis and compositional analysis, FTIR and GCMS. The study revealed that the highest concentration of Volatile matter (75.452%), Bulk density (0.256 %), Swelling index (1.456 %), Cellulose content (61.727 %), Hemicellulose content (4.372 %) and Tannins (0.635 g/ 100g) was observed to occur in Acalypha indica leaf than other experimental plants. In Physalis angulata the percentage composition of fixed carbon (15.251%) and extractive content (1.974 %) was higher than others. Ash content (12.327 %), hemicellulose content (4.372 %), and lignin content (5.531 %) were observed to be higher in the Senna tora leaf than others. Total carbohydrate concentrations (9.619 gm/100 gm) and nitrogen content (2.050 %) were observed to be higher in Euphorbia hirta than others. Total protein (2.321 gm/100 gm), total fat (0.655 gm/100 gm), oxygen content (34.222 %) and Higher heat value (HHV) (16.546 %) were higher in Ziziphus mauritina than others. The existence of functional groups and the relevance of the presence of a specific bioactive component were determined using FTIR (Fourier Transform Infrared Spectroscopy) of the leaves of five plant samples. According to GCMS (Gas Chromatography Mass Spectroscopy), five different medicinal plants contain significant bioactive chemicals. By using GC-MS analysis, a total of 10 bioactive compounds (Acalypha indica, Senna tora) and 8 bioactive compounds (Ziziphus mauritina, Euphorbia hirta, Physalis Angulata) were found in the peaks of methanolic extracts of five potential medicinal plants. The bioactive compounds like Cyclotrisiloxane, Hexamethyl-, Dodecane, 1-Fluoro-, Myo-Inositol, 4-C-Methyl obtained from Acalypha indica leaf extract, Palmitic Acid, Phthalic Acid, Cyclopentadecanol obtained from Senna tora leaf extract and 4-Tert-Octylphenol, TMS Derivative obtained from Euphorbia hirta leaf extract has no records of individual bioactivity as per Dr. Duke’s ethnobotanical and pharmaceutical database and are considered as novel bioactive compounds. Isolation of these compounds and successive bioactivity studies should be the thrust area for future researchers. Also, the current study confirms that specific plant leaves are a great source of important phytochemicals and can be used to make herbal formulations, practical medications, and complementary medicines.

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De, Manna, and Lata Sharma. "A comparative physico-chemical, phytochemical and spectroscopic analysis of two medicinal plants belongs to Euphorbiaceae family: Acalypha indica L. and Euphorbia hirta L. growing in Paschim Medinipur District, West Bengal, India." International Journal of Experimental Research and Review 32 (August 30, 2023): 206–15. http://dx.doi.org/10.52756/ijerr.2023.v32.018.

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Plants belong to Euphorbiaceae family, bearing enormous Medicinal potential due to the presence of various pharmacologically important secondary metabolites. Now a days, with the help of various tools and techniques like FTIR, GCMS researchers are engaged to systematically find out various biologically active phytoconstituents. The present study investigated Acalypha indica L. and Euphorbia hirta L. leaf to establish the fact. Physico-chemical parameters of the experimental plants have been investigated. The result shows that Acalypha indica possesses maximum values on Swelling index, volatile matter, ash contents, fixed carbon, higher heat value, hydrogen content, oxygen content, carbon content, hemicellulose content, lignin content and extractive values. In contrast, the percentage composition of bulk density, carbon content, and nitrogen content is higher in Euphorbia hirta. In the present investigation, the FTIR analysis reveals that Acalypha indica L. possessed different chemical classes like Sulfoxide, Alkene, Carbon Dioxide, Alkane, Alcohol etc., whereas FTIR analysis reveals the presence Alkene, Secondary Alcohol, Conjugated Alkene, Carbon Dioxide, Alkene, Alcohol in Euphorbia hirta L. The methanolic leaf extracts of two different plants have been screened through GC-MS, revealing many important bioactive phytoconstituents. Acalypha indica L. possesses Cyclotrisiloxane, Hexamethyl-, cis-2,4-dimethylamine, S, S-dioxide, 1- nonadecanamine, n, n-dimethyl-, tridecane, 2,2,4,10,12,12-hexamethyl-7-(3,5,5-trimethylsilyl)-, dodecane, 1-fluoro-, whereas, Euphorbia hirta L. possesses myo- inositol, 4-c-methyl-, z,z-6,28-heptatriactontadien-2-one, phytylpalmitate, hexasiloxane, 1,1,3,3,5,5,7,7,9,9,11,11-dodecamethyl-, 4-tert-octylphenol, TMS derivative. Both these plants have chemical substances that have proven bioactivity in human welfare. The GC-MS of leaf methanolic extract reveals that the phytochemical cis-2,4-dimethylthiane, S, S-dioxide have Anticancer (stomach) activities, 1-nonadecanamine, N, N-dimethyl bears Antitumor (nasopharynx) activities, myo-inositol, 4-C- methyl bearing Myo-neuro-stimulant activities and Z, Z-6,28-heptatriactontadien-2-one having Increase zinc bioavailability activities. These activities of individual phytoconstituents have been proven through Dr. Duke's Phytochemical and Ethno-botanical Databases: U.S. Department of Agriculture. This information might be helpful to the pharmacologists, chemists, etc., for future novel drug discovery.

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FLECHTMANN, CARLOS H. W., and GILBERTO J. DE MORAES. "Three new species of eriophyid mites (Acari: Eriophyidae) from the State of São Paulo, Brazil." Zootaxa 23, no. 1 (2002): 1. http://dx.doi.org/10.11646/zootaxa.23.1.1.

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Three new species of eriophyid mites are described from the State of São Paulo, Brazil. Abacarus nectandrae n. sp. and Aceria megalops n. sp. were found on Nectandra membranacea (Sw.) Griseb (Lauraceae) and Guapira opposita (Vell.) Reitz (Nyctaginaceae), respectively, both native trees of the Atlantic Forest. Aceria korykis n. sp. was found on the ornamental Acalypha reptans Sn. (Euphorbiaceae), introduced from India and commonly cultivated in Brazil.

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Isaiarasu, L., N. Sakthivel, J. Ravikumar, and P. Samuthiravelu. "EFFECT OF HERBAL EXTRACTS ON THE MICROBIAL PATHOGENS CAUSING FLACHERIE AND MUSCARDINE DISEASES IN THE MULBERRY SILKWORM, BOMBYX MORI L." Journal of Biopesticides 04, no. 02 (2011): 150–55. http://dx.doi.org/10.57182/jbiopestic.4.2.150-155.

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ABSTRACT A preliminary survey on the incidence of silkworm diseases in ten selected sericulture farms near Srivilliputhur, a hub of sericulture activity in the Virudhunagar district of Tamilnadu, India showed that the incidence of the bacterial diseases, flacherie is quiet common in this region followed by the fungal diseases, muscardine and the viral diseases, Grassarie. Biochemical characterization of the microbes in the haemolymph of diseased silkworm collected during the survey indicated the presence of Bacillus sp., Streptococcus sp., Staphylococcus sp. and Pseudomonas sp. in the culture. The nature of fungal species however, could not be ascertained due to several handicaps including the difficulties encountered during their culture. Studies were carried out in vitro to assess the efficacy of some herbal extracts for the containment of these microbes through turbidimetry analysis and zone of inhibition test. The observations made during this study revealed that the aqueous and alcoholic crude extracts of three herbs such as, Acalypha indica, Ocimum sanctum and Tridax procumbens are effective against these microbes causing flacherie and muscardine diseases in silkworm. The comparison of their effects indicated that alcoholic extracts were generally more effective than aqueous extracts and that the extracts of Tridax procumbens are very effective against these microbial pathogens followed by the extracts from Ocimum sanctum and Acalypha indica. Extensive studies using these extracts on the growth and cocoon production of the mulberry silkworm, Bombyx mori L. are likely to throw much light on the possibility of using such extracts as a prophylactic measure during silkworm rearing to improve silk production.

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T. Sivakumar. "A updated review of Acalypha indica L. as traditional/Ethnomedicinal plant and its pharmacological activities." international journal of engineering technology and management sciences 8, no. 6 (2024): 78–85. https://doi.org/10.46647/ijetms.2024.v08i06.011.

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Acalypha indica L., is an vital Indian medicinal plant and is broadly used in Traditional/Ethnomedicinal, Ayurveda, and Siddha to manage various diseases. It has a wide range of chemical constituents, pharmacological and medicinal applications. Various pharmacological tests have been carried out both in vitro and in vivo and phytoconstituents of medical importance have been identified. Many biological components in good yield and some mainly belonging to cyanogenic glucoside (acalyphin), tannins, flavonoids, pyranoquinolinone alkaloid (flindersin) have been shown to have beneficial biological activities. The extracts and chemical constituents of this plant have useful pharmacological activities. The key pharmacological activities of Acalypha indica are antivenom property and antiobecity activity. Several pharmacological studies of Acalypha indica have demonstrated their antioxidant, antimicrobial, antidiabetic, and antivenom in support of its traditional uses. Suggest a wide range of medicinal uses for cathartic, diuretic, anthelmintic, emetic, expectorant treatment. Therefore, this review contributes to the knowledge of Acalypha indica plant and their Traditional and ethnomedicinal use..

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S., Raveendran. "BIOCONTROL ACTIVITY OF SOLVENT EXTRACTS OF DATURA METEL AND ACALYPHA INDICA AGAINST FUNGAL LEAF PATHOGEN OF ARACHIS HYPOGEA." International Journal of Zoology and Applied Biosciences 2, no. 1 (2017): 1–7. https://doi.org/10.5281/zenodo.1311019.

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Datura metel and Acalypha indica are medicinal plants. These plants are rich in a wide variety of secondary metabolites such as tannins, terpenoid, alkaloids and flavonoid. Among the commercial crops, Groundnut (Arachis hypogea) is economically important and it is grown in India. The seeds contain 50% of non-drying oil and about 35% protein. Fungi are the most important common plant disease causing pathogen. 18 fungal species were isolated from infected Arachis hypogea plants. Bio control activities of the organic solvent plants extracts of D. metel, A. indica was carried out on the various test micro organism using agar well diffusion technique. The extracts restricted the growth of pathogen on the media. The maximum inhibition zone was observed in the extracts of D. metel and A. Indica against Aspergillus niger and Fusarium oxysporum. The minimum inhibition zone was observed in Trichoderma harzianum. Increased concentration of extracts was more effective against fungi. Extracts of D. metel have max zone of inhibition compare to that of A. Indica. The present study concludes that Datura metel was an effective Bio control agent.

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Lingaiah, Guniganti Devender, and Mamidala Estari. "Invitro anti-diabetic activity of selected medicinal plant extracts used by tribals of Adilabad district, Telangana state, India." Biolife 2, no. 4 (2022): 1398–404. https://doi.org/10.5281/zenodo.7228079.

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ABSTRACT Diabetes mellitus is a metabolic disorder characterized by increased blood glucose levels with instability in carbohydrate, fat and protein metabolism. The current study was conducted to find out α-glucosidase and α-amylase inhibitory effect of selected plants (Ficus Religiosa -Stem bark, and Acalypha indica-Leaves) to asses anti-diabetic activity by in vitro. Each plant powder was successively extracted with different organic solvents in increasing polarity by Soxhlet extraction method. The different solvent extracts were further subjected for α-glucosidase and α-amylase enzyme inhibitory assay to assess invitro anti-diabetic activity. The percentage yield of Ficus religiosa stem bark Hexane, chloroform, ethyl acetate, acetone and methanol crude extracts were 23.43%, 27.56%, 12.14%, 14.12% and 2.10% respectively. The IC50 values of Acalypha indica n-hexane, chloroform, ethyl acetate, acetone and methanol extracts were 59 µg/ml, 45 µg/ml, 65 µg/ml, 66 µg/ml and 72 µg/ml, respectively. All extracts inhibited enzyme activity in a dose-dependent manner. Out of the two plant species Acalypha indica chloroform extract was the most active followed by Ficus religiosa based on the IC50 values. A. indica should be further investigated to identify the compounds responsible for its promising in vivo anti-diabetic activity. Keywords: Diabetes mellitus, Acalypha indica, Ficus religiosa, Soxhlet extraction method. REFERENCES Adisakwattana S, Lerdsuwankij O, Poputtachai U, Minipun A, Suparpprom C:Inhibitory activity of cinnamon bark species and their combination effect with acarbose against intestinal α -glucosidase and pancreatic α -amylase. Plant Foods Hum Nutr 2011, 66:143 – 148. Alberti KGMM, Zimmet PZ: Definition, diagnosis and classification of diabetes mellitus and its complications. Report of a WHO Consultation Geneva: WHO, 1999. Ali, H., Houghton, P.J., Soumyanath, A., 2006. [1]-Amylase inhibitory activity of some Malaysian plants used to treat diabetes; with particular reference to Phyllanthus amarus. Journal of Ethnopharmacology 107, 449–455. Asano, N., Ikeda, K., Kasahara, M., Arai, Y., Kizu, H., 2004. Glycosidase-inhibiting pyrrolidines and pyrrolizidines with a long side chain in Scilla peruviana. Journal of Natural Products 67, 846–850. Conforti, F., Statti, G., Loizzo, M.R., Sacchetti, G., Poli, F., Menichini, F., 2005. In Vitro antioxidant effect and inhibition of α-amylase of two varieties of Amaranthus caudatus seeds. Biological and Pharmaceutical Bulletin 28, 1098–1102. E. Sucharitha and M. Estari. 2013. Evaluation of antidiabetic activity of medicinal plant extracts used by tribal communities in rural areas of Warangal district, Andhra Pradesh. Biology and Medicine, 5 (20-25). Gerrits PM, Tsalikian E: Diabetes and fructose metabolism. Am J Clin Nutr 1993, 58:796S – 799S. Ghosal S, Tripathi VK, Chauhan S. Active constituent of Emblica officinalis: Part I. The chemistry and antioxidant effects of two new hydrolysable tannins, emblicanin A and B. Indian J Chem 1996;35:941-8 Hungeling M. cyanogenic and non‐cyanogenic pyridone glucosides  from Acalypha indica (Euphorbiaceae). Phytochemistry 2009; 70(2): 270‐277  Koh LW, Wong LL, Loo YY, Kasapis S, Huang D: Evaluation of different teas against starch digestibility by mammalian glycosidases. J Agric Food Chem 2010, 58:148 – 154. Kotowaroo, M.I., Mahomoodally, M.F., Gurib-Fakim, A., Subratty, A.H., 2006. Screening of traditional antidiabetic medicinal plants of mauritius for possible α-amylase inhibitory effects in vitro. Phytotherapy Research 20, 228–231. Lebovitz HE: Α-glucosidase inhibitors. Endocrinology and Metabolism Clinics of North America. 1997, 26:539-551. Lee, Y.A., Cho, E.J., Tanaka, T., Yokozawa, T., 2007. Inhibitory activities of proanthocyanidinis from persimmon against oxidative stress and digestive enzyme related to diabetes. Journal Nutritional Science Vitaminology 53, 287–292. Pathmanathan  MK,  Uthayarasa  K, Jeyadevan  JP,  Jeyaseelan  EC.  In Vivo Analysis of Some Selected Medicinal Plants.  International Journal of Pharmaceutical & Biological Archives 2010; 1(3):291 – 299. Pereira DF, Cazarolli LH, Lavado C, Mengatto V, Figueiredo MS, Guedes A, Pizzolatti MG, Silva FR: Effects of flavonoids on α -glucosidase activity: potential targets for glucose homeostasis. Nutrition 2011, 27:1161 – 1167. Porika Raju and Estari Mamidala (2015). Anti-diabetic activity of compound isolated from Physalis angulata fruit extracts in alloxan induced diabetic rats. The Ame J Sci & Med Res, 2015,1(1); Pages 1-6. doi:10.17812/ajsmr2015.11.1. Raj J. and Singh KP. Acalypha indica. Central Council of Research in Homeopathic 2000; 22 (1&2) Rajendra Chary Vijayagiri and Estari Mamidala. Preliminary phytochemical and in vitro anti-diabetic activity of Ficus racemosa (L.) stems bark extract. Online International Interdisciplinary Research Journal, Voll-III, Nov 2013. 134-141 Ramasubbu, N., Ragunath, C., Mishra, P.J., Thomas, L.M., Gyemant, G., Kandra, L., 2004. Human salivary α-amylase Trp58 situated at subsite-2 is critical for enzyme activity. European Journal Biochemistry 271, 2517–2529. Raptis SA, Dimitriadis GD: Oral hypoglycemic agents: insulin secretagogues, α-glucosidase inhibitors and insulin sensitizers. Exp Clin Endocrinol Diabetes 2001, 109(Suppl 2):S265 – 87. Sateesh Poojari, Raju Porika and Estari Mamidala. Phytochemical Analysis and in Vitro Antidiabetic Activities of Physalis angulata Fruit Extracts. National Journal of Integrated Research in Medicine (NJIRM) 2014; Vol. 5(2). 34-38. Schmelzer  GH.  Acalypha  indica  Linn.  Plant  Resources  Trop  Africa 2007. Scorpiglione N, Belfiglio M, Carinci F, Cavaliere D, De Curtis A, Franciosi M, Mari E, Sacco M, Tognoni G, Nicolucci A: The effectiveness, safety and epidemiology of the use of acarbose in the treatment of patients with type II diabetes mellitus. A model of medicine-based evidence. Eur J Clin Pharmacol 1999, 55:239 – 249. Sudhir R, Mohan V: Postprandial hyperglycemia in patients with type 2 diabetes mellitus. Treat Endocrinol 2002, 1:105 – 116. WHO Expert Committee on Diabetes Mellitus. Technical Report Series World Health Organization, Geneva, 1980. Zhang Y, Tanaka T, Iwamoto Y, Yang C, Kouno I. Phyllaemblic acid, a novel highly oxygenated norbisabolane from the roots of Phyllanthus emblica. Tetrahedron Lett 2000;41:1781-4

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Prof:, Anarse P. S. "To Study the Effect of Different Plant Extract On Fungal Disease of Brinjal." International Journal of Advance and Applied Research 10, no. 2 (2022): 133–35. https://doi.org/10.5281/zenodo.7462888.

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Abstract :                          In present study the pathogenic fungus was isolated from infected plant parts and deification based on morphological and cultural characters. The efficacy of different plant extracts such as Adhatoda vasica, Aloe Vera, Andrographis paniculate, Azima tetracantha and Cadala India etc were tested to control  brinjal fungal disease. Different concentration of plant extract viewed in the study. All the plant extract showed significant reduction in the growth of fungal plant. Aong the different extracts Adhatoda vasica, Jetropha curcas L, Sapindus emarginatus, Acalypha indica,Cissus quadraqularis was found most effective. Application of plant extract which are easily available for controlling plant diseases are non-pollutive, cost effective, non-hazardous not disturb ecological balance.

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PANT, R. P., ANUJ BHATNAGAR, and MURARI LAL. "Role of alternate host plants in the transmission of apical leaf curl disease of potato caused by tomato leaf curl New Delhi virus - potato (ToLCNDV-pot.) in Northern India." Indian Journal of Agricultural Sciences 88, no. 8 (2018): 1258–62. http://dx.doi.org/10.56093/ijas.v88i8.82565.

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Whitefly (Bemisia tabaci Gennadius) is a plant sap-sucking insect and transmits begomovirus, tomato leaf curl New Delhi virus-potato (ToLCNDV-potato) causing potato apical leaf curl disease has been posing serious threat to potato production in Northern India. Therefore, a field survey was conducted in Northern India during 2013-14 and 2014-15 potato offseason to identify the host plants, activity of whitefly on these plants with confirmation of ToLCNDV-potato through PCR. The presence of whitefly and PCR results revealed that cultivable host plants Abelmoschus esculentus, Capsicum annum, Dahlia pinnata, Luffa cylindrica, Solanum melongena, Tagetes erecta, Vigna radiata and non-cultivable host plants Phyllanthus niruri, Trifolium repens, Acalypha indica and Commelina benghalensis acquired ToLCNDV-potato in due course of time, however some of the alternate host plants were found negative, while whitefly collected from these plant showed positive reaction or vice versa. The findings of this study would help in studying the movement of whitefly and survival of ToLCNDV-potato on alternate host plants for better management of this disease in potato. As a precaution, a care should be taken to remove these plants in the vicinity of potato breeder seed crop in whitefly endemic area for the effective management of apical leaf curl disease of potato.

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Brahmam, Pasumarthi, and Kanikaram Sunita. "Phytochemical Investigation and In vitro Antimalarial Activity of Acalypha indica (L.) and Cocculus hirsutus (L.) From Prakasam District, Andhra Pradesh, India." Biomedical and Pharmacology Journal 11, no. 4 (2018): 2123–34. http://dx.doi.org/10.13005/bpj/1592.

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The present study, report the phytochemical analysis and in vitro antimalarial activity of plants Acalypha indica (L.) and Cocculus hirsutus (L.). The A. indica and C. hirsutus plant was collected from Kadaparajupalle at Dornala mandal, Prakasam district, Andhra Pradesh, India. Leaf, stem bark and root crude extracts prepared in Soxhlet apparatus with chloroform, ethyl acetate and methanol solvents. The preliminary phytochemical screening of these extracts was conducted by following the standard methods. These extracts were tested for in vitro antimalarial activity against 3D7 and K1 strains of Plasmodium falciparum by standard laboratory protocol. In vitro cytotoxicity of the extracts was also tested by following standard laboratory method. The phytochemical screening has revealed the presence of alkaloids, saponins, terpenoids & steroids, tannins, anthocyanidins, phenolic compounds, coumarins, quinones, resins and glycosides. Amongst all the extracts screened for antimalarial activity, the leaf chloroform and ethyl acetate extracts of A. indica shown IC50 values of 3.34 µg/mL and 3.71 µg/mL respectively against 3D7 strain; the leaf chloroform and ethyl acetate extracts of A. indica shown IC50 values of 1.47 µg/mL and 2.32 µg/mL respectively against K1 strain; the root chloroform and methanol extracts of C. hirsutus shown IC50 values of <0.78 µg/mL and 3.714 µg/mL respectively against 3D7 strain; the root chloroform and methanol extracts of C. hirsutus shown IC50 values of <0.78 µg/mL and 2.10 µg/mL respectively against K1 strain. Thus, the above extracts have shown very active antimalarial activity against 3D7 and K1 strains. And all the extracts were non-toxic showing CC50 values of >20 µg/mL against Vero cell line. The presence of high alkaloids, flavonoids and terpenoids of the plant extracts suggest their antioxidant potential and justifies their therapeutic action which could be used for the drug formulation. The chloroform root extract of C. hirsutus has shown excellent antimalarial activity which can be used for the development of new antimalarial drug policies.

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Singh, Devpal, and Sarika Yadav. "Ethno-botanical survey of some useful plants of Soor Sarovar Bird Sanctuary, Agra District, U.P., India." International Journal of Agricultural Invention 7, no. 2 (2022): 138–43. https://doi.org/10.46492/ijai/2022.7.2.4.

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Soor Sarovar Bird Sanctuary (SSBS) is situated on the way of Agra to Delhi about 20 Km from Agra. It has been recently recognized as “Ramsar Site” and includes a large lake (7.99 Km2) surrounded by dense forest extending up to Yamuna river. This forest area was surveyed during July 2021 to June 2022 to enumerate plant species used by local villages for medicinal use. A total of 60 plant species were recorded which belong to 27 angiospermic families. These plants include 41 herbs, 3 shrubs, 12 trees and 4 climbers. On the basis of interview with hakim, Vaidh and local elderly people (villages), the most common medicinal plant species are Abutilon indicum, Acalypha indica, Achyranthus aspara, Argemone mexicana, Asparagus racemosus, Azadirachta indica, Bauhinia variegate, Boerhavia diffusa, Calotropis procera, Cassia fistula, Cassia tora, Catharanthus roseus, Eclipta alba, Eucalyptus globules, Euphorbia hirta, Evolvulus alsinoides, Ficus carica, Ficus glomerata, Portulaca oleracea, Prosopis juliflora, Rumex dentatus, Solanum nigrum and Vernonia anthelmentica.

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Saranya, S., R. Raja JeyaSekar, and S. M. Vijila. "Synergistic Effect of Herbals and Nanoparticles - Zinc Oxide on Silkworm Pathogens." UTTAR PRADESH JOURNAL OF ZOOLOGY 44, no. 23 (2023): 236–46. http://dx.doi.org/10.56557/upjoz/2023/v44i233784.

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Acalypha indica L. is an annual herbaceous weed and widely distributed throughout the tropical region of India. It has been wound healing activity, antibacterial activity and antiurolithiatic activity. The herbal plant Murrayakoenigii have been used as analgescis, astringents, antidysenterics or febrifuges in folk medicine in China and other Asian countries. The antibacterial responses of Zinc oxide (ZnO) against Staphylococcus sp. SA 3were investigated. The acetone, ethyl acetate and methanol extracts of A. indica showed minimum inhibitory activity4 ±0.31mm, 10±0.18 mm and 6±0.23 mm respectively and maximum inhibitory activity 8±0.15 mm, 20±0.37 mm and 12±0.14mm at different concentration (0.5, 1.0, 1.5 and 2.0 µl) against the bacterial pathogen Staphylococcus sp. SA 3. The acetone and methanol extracts of M. koenigii showed minimum inhibitory activity 6±0.25 mm and 6±0.25 mm and maximum inhibitory activity 10± 0.18 mm and 8±0.15 mm. The ethyl acetate extract of M. koenigii did not showed inhibitory activity. In the combined effect of acetone, ethyl acetate and methanol extracts of A. indica and ZnO showed minimum inhibitory activity 4±0.31 mm, 10±0.13 mm and 4±0.31 mm respectively and maximum inhibitory activity 10± 0.13 mm, 22± 0.30 mm and 8±0.15 mm respectively. The combined effect of acetone, ethyl acetate and methanol extracts of M. koenigii and ZnO showed minimum inhibitory activity 16±0.08 mm and 6± 0.23 mm. The ethyl acetate extract of M. koenigii showed no inhibitory activity and maximum inhibitory 20± 0.37 mm, 2± 0.04 mm and 10± 0.13 mm respectively. The GC-MS analysis of methanol extract of A. indica showed the presence of 8 phytoconstituents and the nanoparticle ZnO impregnated ethyl acetate extract of A. indica showed the presence of 11 phytoconstituents.

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Kantwa, Suman, C. K. Jadon, J. P. Tetarwal, Baldev Ram, S. R. Kantwa, and R. K. Yadav. "Effect of Weed Management Practices on Weed Dynamics, Yield Attributes and Yield of Maize." International Journal of Bio-resource and Stress Management 11, no. 5 (2020): 488–93. http://dx.doi.org/10.23910/1.2020.2133.

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A field experiment was conducted at Research Farm of Agricultural Research Station, Ummedganj, Kota (Agriculture University, Kota), Rajasthan, India during kharif 2019 to find out the most effective herbicide combination for limiting the menace of weeds in maize. Results showed that density of monocot weeds were observed more than dicot weeds during the experimentation. The prominent weeds were Echinochloa colona, Cyperus rotundus, Digera arvensis, Amaranthus viridis, Acalypha indica and Trianthema portulacastrum etc. caused about 58.3% reduction in grain yield as over two hand weeding at 20 and 40 DAS. In general, grassy weeds were better controlled by herbicides than broad leaves weeds. Among herbicides, maximum weed control efficiency (72.18%) was achieved with application of atrazine 500 g a.i. ha-1 (PE) followed by topramezone 25.2 g a.i. ha-1 at 20-25 DAS (72.18%) which is very close to two hand weeding at 20 and 40 DAS. Furthermore, this treatment also produced higher grain (3496 kg ha-1) and stover yield (6460 kg ha-1) which was at par with atrazine 500 g a.i. ha-1 (PE) followed by tembotrione 120.75 g a.i. ha-1 (20-25 DAS) and atrazine 500 g a.i. ha-1 (PE)+hand weeding 30 DAS with in-situ weeds mulching. Thus, pre-emergence application of atrazine 500 g a.i. ha-1 (PE) followed by topramezone 25.2 g a.i. ha-1 at 20-25 DAS is recommended for better weed control and yield of maize.

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Thambiraj, J., S. Paulsamy, and R. Sevukaperumal. "Evaluation of in vitro antioxidant activity in the traditional medicinal shrub of western districts of Tamilnadu, India, Acalypha fruticosa Forssk. (Euphorbiaceae)." Asian Pacific Journal of Tropical Biomedicine 2, no. 1 (2012): S127—S130. http://dx.doi.org/10.1016/s2221-1691(12)60142-7.

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Rahmi Nurhaini, Muchson Arrosyid, and Titik Susanti. "Identifikasi Golongan Senyawa Flavonoid Ekstrak Etanol Daun Anting-Anting (Acalypha indica L.)." CERATA Jurnal Ilmu Farmasi 12, no. 1 (2021): 42–46. http://dx.doi.org/10.61902/cerata.v12i1.225.

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    Anting-anting leaf is one type of plant that has medicinal properties and has not been widely used by the community. Previous research stated that the ethanol extract of Anting-anting has secondary metabolite compounds such as saponins, flavonoids, alkaloids, tannins. Flavonoids are a source of antioxidants that can inhibit premature aging caused by free radicals produced by pollution. Flavonoids can be used to avoid deadly diseases including heart disease and cancer. The purpose of this study was to determine the class of flavonoid compounds present in anting-anting leaf (Acalypha indica L.). The method used in this study was a color reaction, the material used was anting-anting leaf (Acalypa indica L.), CH3COONa. , FeCl3, Na2CO3, NaOH 0.1 N, CH3COOPb, H2¬SO4. The results of this study indicate that the Anting-anting extract (Acalypa Indica L.) positively contains flavonoids of the anthocyanidin group, using Na2CO3 reagent, the color formed is green, and positive contains flavonol and flavone groups using H2SO4 and NaOH reagents, the color formed is yellow.    

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Poonam, Charde Namrata Waghmare* Pooja Mahajan Kavita Mate Poonam Pise. "Analyzing potential phyto-constituents from Acalypha indica Linn (Haritamanjari) in management of Asthma: computational approach." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 1258–70. https://doi.org/10.5281/zenodo.15365708.

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Background and Aim: Asthma is a major global health concern, necessitating the exploration of natural alternative to synthetic drugs due to their side effects. This study investigates the anti-asthmatic potential of Acalypha indica Linn through in-silico molecular docking. Material and Methods: Six phytoconstituents from Acalypha indica Linn and standard drugs used as anti-asthmatic agents were selected. Molecular docking was performed using AutoDock 4.5.6 against key asthmatic targets including, PDE4B, M3 receptor, IL-13, and ALOX. Interactions were visualized using Biovia discovery studio. Result: The phytoconstituents exhibited higher binding affinities with target proteins compared to standard drugs. Notably, Stigmasterol, Aurantiamide, and Kaempferol showed strong interactions with PDE4B, with binding energies of -12.00, -9.78, and -6.53 kcal/mol, respectively, surpassing Theophylline’s -4.98 kcal/mol. For the M3 muscarinic receptor Aurantiamide, Acalyphin, and Kaempferol demonstrated binding energies of -10.68, -7.09, and -6.55 kcal/mol, outperforming Ipratropium bromide’s -8.48 kcal/mol. Stigmasterol, and Aurantiamide exhibited robust binding with the IL-13, with energies of -7.47, and -6.37 kcal/mol, respectively, compared to Fluticasone’s -5.93 kcal/mol. Additionally, Stigmasterol, Aurantiamide, and Caffeic acid interacted strongly with the ALOX5, with binding energies of -10.53, -8.41, and -6.27 kcal/mol, respectively, exceeding Montekulast’s -9.14 kcal/mol. Conclusion: This research highlights the therapeutic potential of Acalypha indica Linn in management of asthma, offering a promising alternative to synthetic drugs. The findings support further experimental validation and clinical application, paving the way for novel anti-asthmatic drug discovery.

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R, Kurnijasanti, Winarti D, Wahyuni R.S., et al. "Hispathology of Coronary artery of male rat (Ratus Norvegicus) with high fat diet after being given ethanol extract of Indian acalypha (Acalipha indica. L)." KnE Life Sciences 3, no. 6 (2017): 241. http://dx.doi.org/10.18502/kls.v3i6.1133.

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This research aims to know the effect of ethanol extract of Indian acalypha (Acalipha indica L) to histopathology of coronary artery of male rat (Ratus norvegicus) with high fat diet. Twenty male rats (Rattus Norvegicus) males aged 3-5 months with mean weight 200 grams were divided into 5 groups and 4 replications. Group 1 (negative control) was only given standard feed and distilled on ad libidum. Four groups (Positive control, Treatment 1, 2 and 3) were made hypercholesterolaemia by administering 1 mL peroral pork oil for 56 days. On day 14, the cholesterol levels were checked. After hypercholesterolaemia, from day 15 to day 56, each group was given ethanol extract of Indian acalypha peroral with a dose of 200 g / kg BW (P1), 400 g / kg BW (P2) and 800 g / kgBW (P3), whereas the positive control groups were not given ethanol extract of Indian acalypha. On day 57, the dying rat was dissected for the removal of the cardiac organ and the making of coronary artery histopathological preparation. Data on histopathologic observation of coronary artery were analyzed by the Kruskal Wallis test, and if there was a significant difference between treatment groups (p <0.05), then it continued with the Mann-Whitney test. The results showed that in infiltration of fat cells and endothelial cells that experienced damage treatment P1, P2, and P3 which were given extracts of Indian acalypha experienced decrease compared to positive control treatment groups. The result of statistical test of fat cells and endothelial cells in the coronary artery that experienced damage showed significant differences between treatment groups (p <0.05), whereas in the statistical test of coronary artery foam cells showed no significant differences between treatment groups (P> 0 , 05). From the research, it can be concluded that ethanol extract of Indian acalypha (Acalipha indica L) can improve histopathology coronary artery of rat fed high fat diet.

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Mu'nisa, A., Alimuddin Ali, A. Muflihunna, Balqis Dinarty Jamaluddin, and Maulyda Awwaliah P. "Efektivitas Ekstrak Daun Acalypha Indica dan Tanaman Imperata Cylindrica terhadap Kadar Glukosa Mencit (Mus Musculus L) Hiperglikemia." Sainsmat : Jurnal Ilmiah Ilmu Pengetahuan Alam 9, no. 1 (2020): 39. http://dx.doi.org/10.35580/sainsmat91141892020.

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Penelitian ini bertujuan untuk mengetahui efektivitas ekstrak Acalypha indica dan tanaman Imperata cylindrica terhadap kadar glukosa mencit (Mus musculus L) hiperglikemia. Penelitian ini menggunakan mencit jantan strain ICR sebanyak 40 ekor yang dibagi dalam 8 kelompok perlakuan, yaitu kelompok mencit normal, kelompok mencit hiperglikemia, dan kelompok mencit dengan pemberian ekstrak methanol Acalypha indica dan tanaman Imperata cylindrical pada masing-masing dosis 150 dan 250 mg/Kg bb. Hasil penelitian menunjukkan bahwa ekstrak daun Acalypha indicadan tanaman Imperata cylindrica menunjukkan penurunan kadar glukosa darah mencit sebesar 47-49%. Kesimpulan penelitian ini adalah adanya efektivitas ekstrak methanol Acalypha indica dan tanaman Imperata cylindrical berpengaruh terhadap penurunan kadar glukosa darah pada mencit hiperglikemia. Kata Kunci: Acalypha Indica,Imperata Cylindrical,Kadar Glukosa This study aims to determine the effectiveness of the extract of Acalypha indica and plant Imperata cylindrica on glucose levels of mice (Mus musculus L) hyperglycemia. This study used 40 male ICR strain male mice which were divided into 8 treatment groups, namely normal mice group, hyperglycemia mice group, and mice group by giving methanol extract Acalypha indica and Imperata cylindrical plants at each dose of 150 and 250 mg / Kg bb. The results showed that the extract of the leaves of Acalypha indica and Imperata cylindrica plants showed a decrease in blood glucose levels of mice by 47-49%. The conclusion of this research is the effectiveness of the methanol extract of Acalypha indica and the Imperata cylindrical plant influences the decrease in blood glucose levels in hyperglycemia mice.Keywords: Acalypha Indica, Cylindrical Imperata, Glucose Level

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Mani, M., A. Krishnamoorthy, and C. Shivaraju. "Biological Suppression of Major Mealybug Species on Horticultural Crops in India." Journal of Horticultural Sciences 6, no. 2 (2011): 85–100. http://dx.doi.org/10.24154/jhs.v6i2.412.

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Mealybugs, known to be 'hard to kill pests', live in protected areas and most stages in their life cycle are covered in a waxy coating. Several insecticides are found ineffective against mealybugs. Fortunately, mealybugs - being sessile insects - are more amenable to biological control. The exotic parasitoid, Leptomastix dactylopii How., was found to be highly effective in suppressing citrus mealybug, Planococcus citri (Risso.) permanantly on citrus, sapota, guava, pomegranate and coffee. This is one of the recent successes in classical biological control attempts in India. However, the Australian ladybird beetle, Cryptolaemus montrouzieri Muls., often provides spectacular control of heavy infestation of P. citri on acid lime, lemon, sweet orange, pummelo, Crossandra and custard apple. Though Anagyrus dactylopii (How.), is a potential parasitoid of pink hibiscus mealybug, Maconellicoccus hirsutus (Green), on grapes, releases of C. montrouzieri only help in suppression of the pink hibiscus mealybug on grapes, ber, guava, sapota, custard apple, citrus and hibiscus. The encyrtid parasitoid, Tetracnemoidea indica (Ayyar), was able to check the oriental mealybug, Planococcus lilacinus (Ckll.) on acid lime and pomegranate. The predators, C. montrouzieri and Spalgis epeus Westwood, also play a major role in suppression of P. lilacinus on guava, ber, sapota and chow-chow. The local parasitoid, A. dactylopii was seen to play a major role in suppression of spherical mealybug, Nipaecoccus viridis (Maskell) on citrus and jackfruit. Nevertheless, releases of C. montrouzieri are found highly effective in controlling N. viridis on acid lime and pummelo. Similarly release of C. montrouzieri is found to be highly effective in controlling striped mealybug, Ferrisia virgata (Ckll.), on guava, tuberose and Acalypha in 30-40 days of release. A local parasitoid, Aenasius advena Comp., also plays a major role in suppression of F. virgata on guava, mango, guava, hibiscus, fig, citrus, etc. Release of the coccinellid predator, C. montrouzieri, was found very effective in controlling the mango coccid, Rastrococcus iceryoides (Green) on mango and also on the medicinal plant Decalepis hamiltonii. The encyrtid, Praleurocerus viridis (Agarwal), was found very effective in reducing populations of R. iceryoides on guava. Spalgis epeus was found to be the predominant predator of the papaya mealybug, Paracoccus marginatus Williams and de Granara Willink, but releases of the exotic parasitoid, Acerophagus papayae(Noyes&Schauff), only provide excellent control of P. marginatus within 3-4 months of release. The second successful classical biological control attempt on mealybugs in India. The brinjal mealybug, Coccidohystrix insolita (Green), is known to attack brinjal, Coleus, Hibiscus, etc. Cryptolaemus montrouzieri effectively controlled mealybugs on these three crops in 30-40 days of release. Verticillium lecanii Zimm. (Phule bugicide @ 2g/L) is found to be effective in killing the mealybug. Other fungal pathogens, viz., Beauveria bassiana (Bals.) Vuill and Metarhizium anisopliae (Metch.), are also seen to infect mealybugs in rainy season under humid conditions.

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G., Supriya Reddy, Sai Nandini Akula, Haripriya Bommidi та ін. "In-Vitro Anti-Diabetic Activity of Acalypha indica by Using Α - Amylase Inhibition Assay". In-Vitro Anti-Diabetic Activity of Acalypha indica by Using Α - Amylase Inhibition Assay 8, № 11 (2023): 3. https://doi.org/10.5281/zenodo.10353398.

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Medicinal plants have been used as remedies for many illnesses for a very long time all throughout the world. Acalypha indica is a kind of plant with an inflorescence resembling catkins. Despite being a weed, Acalypha indica is recognized by the locals as a valuable source of medication for a number of therapeutic therapies. Acalypha indica Linn is a plant that may have the ability to lower blood glucose levels. Acalypha indica Linn is one of the alternative herbal treatments for type-2 diabetes mellitus. Acalypha indica extract can be used to treat type-2 diabetes in addition to metformin therapy as well as to avoid insulin resistance in healthy individuals. According to this research, the findings of the alpha amylase enzyme test using the ethanol and pet ether extracts of the Acalypha indica plant suggested possible anti-diabetic efficacy based on its inhibitory activity (%). When acarbose and the potential for its anti-diabetic effects were evaluated, pet ether extract shown a better potential for suppressing alpha amylase's enzymatic activity. This was in contrast to ethanol extract.Keywords:- Acalypha indica, Diabetes, Phytochemical Screening, α - amylase inhibition assay.

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Sisein, Eboh Abraham, Azibanasamesa D. C. Owaba, and Robert Owabhel Faith. "HPLC Profile of Bioactives and Antioxidant Potential in Acalypha indica Extract." Asian Journal of Biochemistry, Genetics and Molecular Biology 16, no. 10 (2024): 35–41. http://dx.doi.org/10.9734/ajbgmb/2024/v16i10411.

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Acalypha indica is a plant found in many parts of Africa and Asia. The plant is used for the treatment of many respiratory diseases, management of cancers, diabetes and other diseases. The leaves of Acalypha indica were harvested, washed and shade dried. They were later extracted with methanol. The methanolic extract of Acalypha indica was subjected to DPPH radical scavenging assay, total antioxidant and HPLC quantification of phenols and flavonoids. The result showed a percentage yield of 5.72 %. Also the antioxidant capacity of Acalypha indicia based on the phosphomolybdenum method showed 13.60 ± 0.21 mg AAE/g extract. The DPPH radical scavenging potential of Acalypha indica showed that at 100 – 1000 µg/ml, the extract of Acalypha indica inhibited 7.2 ± 0.35 – 65.13 ± 1.53 % of DPPH radical as compared with standard gallic acid. The phenolics and flavonoids detected through HPLC are shown in Table 3. The phenolics and polyphenols with higher quantity in Extract of Acalypha indica are naringenin (169.91 mg/100 g), gallic acid (131.51 mg/100 g), rutin (76.72 mg/100 g), syringic acid (35.75 mg/100 g), ferulic acid (30.10 mg/100 g) and quercetin (11.36 mg/100 g). The results showed that Acalypha indica possesses antiradical, total antioxidant properties including a wide range of phenols and polyphenols. Therefore the extract can be a source of dietary supplement. This plant extract is a source of medicine if further research is applied.

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Karthika K, Karthika K., Ragul B. Ragul B, Swetha S. Swetha S, Wishwaa J. Wishwaa J, and Wishwaa J. Wishwaa J. "Formulation and Development of Facecream using Borassus Flabellifer and Acalpha Indica." International Journal of Pharmaceutical Research and Applications 09, no. 06 (2024): 303–6. https://doi.org/10.35629/4494-0906303306.

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This study aimed to develop a face cream using natural extracts from Borassus flabellifer (palmyra palm) and Acalypha indica (Indian nettle) due to their skin benefits. Borassus flabellifer is rich in vitamins, minerals, and antioxidants that aid in skin nourishment, hydration, and protection against oxidative stress, while Acalypha indica has anti-inflammatory, antimicrobial, and wound-healing properties beneficial for treating acne and irritation. Active compounds were extracted from both plants using solvent extraction techniques and incorporated into a cream base. Various formulations were created by adjusting extract concentrations to find the optimal combination for efficacy and stability, with physicochemical properties such as pH, viscosity, spreadability, and stability evaluated to ensure quality and safety. Preliminary tests showed good stability and maintained beneficial properties, and in vitro studies indicated potential for enhancing skin hydration, reducing inflammation, and providing antimicrobial effects. Future in vivo testing and consumer trials are planned to validate the formulation's efficacy and safety. In conclusion, the face cream with Borassus flabellifer and Acalypha indica extracts shows promise as a natural and effective skincare product, highlighting the potential of traditional medicinal plants in modern cosmetics.

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Kumar N, Ramesh. "Evaluation of Antioxidant and Antidiabetic Potential of Acalypha indica leaf extract: Identification of Bioactive Factors." Bioscience Biotechnology Research Communications 16, no. 3 (2023): 197–206. http://dx.doi.org/10.21786/bbrc/16.3.10.

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The present investigation is intended to prepare Acalypha indica leaf extract and assess the antioxidant and glucose-lowering effects utilizing in vitro models. The plant methanolic extract of Acalypha indica leaves was exposed to phytochemical examination to identify the bioactive factors by GC-MS. We assessed the antioxidant properties of the extract by using the DPPH scavenging method, ABTS assay, TBARS assay and NO assay. Likewise, the anti-diabetic activity was assessed by ɑ-amylase and α-glucosidase enzyme inhibition and glucose diffusion inhibitory techniques. We found that methanolic extract of Acalypha indica leaves contains a high measure of phenolics, flavonoids and tannins. The GC-MS assay identified the bioactive components. We also found that methanolic extract of Acalypha indica leaves had significant higher antioxidant and glucose-lowering effects. In conclusion, it could be reasoned that due to the nearness of antioxidant components, the methanolic leaf extract of Acalypha indica has good potential in the control of hyperglycemia, diabetes and the related state of oxidative stress.

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S. SENTHILKUMAR, P. KUMAR SINGH, and C. KIRUBA RANI. "Pharmacological evaluation of the anti-ulcer and anti-arthritic potential of ethanolic extract of acalypha indica linn." World Journal of Biology Pharmacy and Health Sciences 22, no. 2 (2025): 147–54. https://doi.org/10.30574/wjbphs.2025.22.2.0471.

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The objective of present study to evaluate the anti-ulcer and anti-arthritic activity of ethanolic leaf extract of Acalypha indica. The anti-ulcer activity of ethanolic extract of Acalypha indica was investigated by pylorous ligation and indomethacin induced gastric ulcer in rats. The cause of ulceration in patients is mainly due to hyper secretion of gastric acid and pepsin. Acalypha indica plant extract some of the most attractive sources of new drugs and have been shown to produce promising results in the treatment of gastric ulcers. Rheumatoid arthritis is a systemic auto immune disease characterized by articular inflammation that eventually leads to the destructions of joints. The present work is aimed to evaluate the anti-arthritic effect of plant Acalypha indica extract by Freund’s Complete Adjuvant (FCA) induced arthritis in rats. Medicinal plants possess numerous active phyto constituents that are responsible for several biological activities. Acalypha indica is very important medicinal plant, to possess anti-ulcer and anti-arthritic activity.

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Nahrstedt, A., M. Hungeling, and F. Petereit. "Flavonoids from Acalypha indica." Fitoterapia 77, no. 6 (2006): 484–86. http://dx.doi.org/10.1016/j.fitote.2006.04.007.

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Edhiatmi, Marsetyo, Wawaimuli Arozal, and Erni H. Purwaningsih. "Efek Kombinasi Ekstrak Etanol Acalypha indica dan Centella asiatica pada Jantung Tikus Pascahipoksia: Gen Hif-1a, Troponin I dan Stres Oksidatif." Jurnal Jamu Indonesia 1, no. 2 (2016): 20–29. http://dx.doi.org/10.29244/jji.v1i2.15.

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Hipoksia meningkatkan pembentukan dan pelepasan spesies oksigen reaktif (ROS). Sel mempunyai mekanisme melindungi diri terhadap kerusakan akibat pembentukan ROS yang terjadi secara alami. Jika pembentukan radikal bebas terjadi berlebihan maka dapat menyebabkan stres oksidatif yang memicu kerusakan sel terutama pada jantung. Sehingga tubuh memerlukan asupan antioksidan. Acalypha indica dan Centella asiatica terbukti memiliki efek antioksidan dan melindungi banyak organ dari kondisi hipoksia, sehingga penelitian ini dilakukan dengan tujuan untuk mengetahui efek antioksidan kombinasi ekstrak etanol Acalypha indica dan Centella asiatica pada organ jantung tikus Spraque-Dawley pascahipoksia. Tiga puluh lima ekor tikus Sprague-Dawley jantan diinduksi hipoksia selama 7 hari dalam ruang khusus, kemudian diberi perlakuan. Ekstrak Acalypha indica, ekstrak Centella asiatica dan kombinasinya diberikan kepada kelompok tikus yang telah dibagi menjadi grup A (hipoksia dan diberi air), B (hipoksia dan diberi kombinasi Acalypha indica 200 mg/kgBB dan Centella asiatica 150 mg/kgBB), C (hipoksia dan diberi kombinasi Acalypha indica 250 mg/kgBB dan Centella asiatica 100 mg/kgBB), D (hipoksia dan diberi Acalypha indica 250 mg/kgBB), E (hipoksia dan diberi Centella asiatica 150 mg/kgBB), F (hipoksia dan diberi vitamin C 100mg/kgBB) dan kelompok normal. Perlakuan diberikan secara oral selama 7 hari setelah hipoksia. Parameter yang diamati adalah ekspresi mRNA HIF-1α, kadar MDA, aktivitas enzim SOD dan ekspresi mRNA cTnI. Tidak terdapat perbedaan bermakna pada ekspresi HIF-1α antara grup A dan kelompok tikus normal (p>0,05). Kadar MDA meningkat signifikan pada grup A (p<0,05) dibanding tikus normal. Kadar MDA grup D mengalami penurunan secara signifikan (p<0,05) dibanding grup A. Aktivitas SOD menurun signifikan pada grup A (p<0,05) dibanding tikus normal. Aktivitas SOD grup B dan E (p<0,05) mengalami peningkatan secara signifikan dibanding grup A. Grup B meningkat signifikan (p<0,05) dibanding grup E. Tidak terdapat perbedaan bermakna antar kelompok perlakuan pada Ekspresi cTnI. Tidak terdapat korelasi antara kadar MDA dan aktivitas SOD serta ekspresi mRNA HIF-1a dan mRNA cTnI. Pemberian kombinasi ekstrak Acalypha indica dan Centella asiatica tidak dapat membantu memproteksi kerusakan jantung pascahipoksia.

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Edhiatmi, Marsetyo, Wawaimuli Arozal, and Erni H Purwaningsih. "Efek Kombinasi Ekstrak Etanol Acalypha indica dan Centella asiatica pada Jantung Tikus Pascahipoksia: Gen Hif-1a, Troponin I dan Stres Oksidatif." Jurnal Jamu Indonesia 1, no. 2 (2016): 20–30. http://dx.doi.org/10.29244/jjidn.v1i2.30609.

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Hipoksia meningkatkan pembentukan dan pelepasan spesies oksigen reaktif (ROS). Sel mempunyai mekanisme melindungi diri terhadap kerusakan akibat pembentukan ROS yang terjadi secara alami. Jika pembentukan radikal bebas terjadi berlebihan maka dapat menyebabkan stres oksidatif yang memicu kerusakan sel terutama pada jantung. Sehingga tubuh memerlukan asupan antioksidan. Acalypha indica dan Centella asiatica terbukti memiliki efek antioksidan dan melindungi banyak organ dari kondisi hipoksia, sehingga penelitian ini dilakukan dengan tujuan untuk mengetahui efek antioksidan kombinasi ekstrak etanol Acalypha indica dan Centella asiatica pada organ jantung tikus Spraque-Dawley pascahipoksia. Tiga puluh lima ekor tikus Sprague-Dawley jantan diinduksi hipoksia selama 7 hari dalam ruang khusus, kemudian diberi perlakuan. Ekstrak Acalypha indica, ekstrak Centella asiatica dan kombinasinya diberikan kepada kelompok tikus yang telah dibagi menjadi grup A (hipoksia dan diberi air), B (hipoksia dan diberi kombinasi Acalypha indica 200 mg/kgBB dan Centella asiatica 150 mg/kgBB), C (hipoksia dan diberi kombinasi Acalypha indica 250 mg/kgBB dan Centella asiatica 100 mg/kgBB), D (hipoksia dan diberi Acalypha indica 250 mg/kgBB), E (hipoksia dan diberi Centella asiatica 150 mg/kgBB), F (hipoksia dan diberi vitamin C 100mg/kgBB) dan kelompok normal. Perlakuan diberikan secara oral selama 7 hari setelah hipoksia. Parameter yang diamati adalah ekspresi mRNA HIF-1α, kadar MDA, aktivitas enzim SOD dan ekspresi mRNA cTnI. Tidak terdapat perbedaan bermakna pada ekspresi HIF-1α antara grup A dan kelompok tikus normal (p>0,05). Kadar MDA meningkat signifikan pada grup A (p<0,05) dibanding tikus normal. Kadar MDA grup D mengalami penurunan secara signifikan (p<0,05) dibanding grup A. Aktivitas SOD menurun signifikan pada grup A (p<0,05) dibanding tikus normal. Aktivitas SOD grup B dan E (p<0,05) mengalami peningkatan secara signifikan dibanding grup A. Grup B meningkat signifikan (p<0,05) dibanding grup E. Tidak terdapat perbedaan bermakna antar kelompok perlakuan pada Ekspresi cTnI. Tidak terdapat korelasi antara kadar MDA dan aktivitas SOD serta ekspresi mRNA HIF-1a dan mRNA cTnI. Pemberian kombinasi ekstrak Acalypha indica dan Centella asiatica tidak dapat membantu memproteksi kerusakan jantung pascahipoksia.

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Dewi, Dewa Ayu Agung Puspita, Ari Estuningtyas, and Erni H. Purwaningsih. "EFFECT OF EXTRACT ACALYPHA INDICA L. ON LIPID PROFILE AND CARDIAC TROPONIN-T OF RATS FED WITH HIGH FRUCTOSE AND CHOLESTEROL DIET." Journal of Southwest Jiaotong University 57, no. 1 (2022): 426–33. http://dx.doi.org/10.35741/issn.0258-2724.57.1.39.

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Consumption of high-fructose and high-fat foods has increased dramatically in the last decade has been developing metabolic syndrome. This study aimed to investigate how Acalypha indica L. impacts cardiac damage and hyperlipidemia, leading to metabolic syndrome through a high-fructose-cholesterol diet (HFCD) in rats. Twenty-four Sprague-Dawley rats were induced with HFCD for 12 weeks. These rats were randomly classified into four treatment groups: HFCD, 31 mg/kg BW/day of gemfibrozil, 400 mg/kg BW/day of Acalypha indica, and 400 mg/kg BW/day of Acalypha indica combined with 31 mg/kg BW/day of gemfibrozil. They were then treated according to their respective groups for eight weeks. Cardiac damage parameters used in this study were troponin and lipid profile. After eight weeks of treatment, there were significant reductions in lipid profile (p<0.001), the most significant in the Acalypha indica + gemfibrozil group, with triglyceride levels decreasing as much as 63.57%, low-density lipoprotein 55.33%, total cholesterol 51.59%, troponin 73.17%, and high-density lipoprotein level increased by 80.55% compared to the group without therapy. Therefore, it was concluded that HFCD could increase the risk of cardiac damage through rising lipid profile and troponin-T levels. Administration of Acalypha indica as an adjuvant to gemfibrozil was proven to give the highest protection to the heart.

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Nambiar, Mandeth Kodiyil Geetha, and Vijesh Varghese. "In Vitro Hepatoprotective Activity of Methanolic Leaf Extract of Acalypha indica Against CCl4 Induced Hepatotoxicity in Goat Liver Slice Culture." Trends in Sciences 20, no. 4 (2023): 4562. http://dx.doi.org/10.48048/tis.2023.4562.

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Plants used in traditional medicine may constitute an important source of new biologically active compounds. Acalypha indica is one of the weed plants that contain important medicinal values for human health applications. The present study was undertaken to assess the hepatoprotective activity of methanolic leaf extract of Acalypha indica in goat liver slice culture against carbon tetrachloride (CCl4) to prove its efficacy against liver disorders CCl4 was used to induce hepatotoxicity in liver slice of goat. The cytotoxicity induced by CCl4 was estimated by quantifying the release of marker enzymes such as alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), acid phosphatase (ACP) and lactate dehydrogenase (LDH). Also, the degree of hepatic damage was measured by estimating the levels of lipid peroxidation (LPO) of hepatocytes membrane lipids. The treatment of liver cells with CCl4 caused twice increase in LPO of cells besides release of LDH, ALT, AST, ACP and ALP by 6.55, 3.89, 3.31, 2.69 and 2.50 times, respectively as compared to untreated liver cells. Thus, a toxic effect of CCl4 was significantly reduced by the treatment of methanolic leaf extract of Acalypha indica, silymarin and quercetin. The free radical scavenging activity of plant extract was estimated by 2, 2-diphenylpicrylhydrazyl (DPPH) method and IC50 is 65.12 ± 2.27 μg/mL. Qualitative analysis of flavonoid indicates the presence of flavonoids in plant extract. These results indicate that all concentration of plant extract of Acalypha indica, silymarin and quercetin protect the liver cells from CCl4 induced oxidative/free radical mediated damage in vitro. The hepatoprotective activity of methanolic extract of Acalypha indica extract is due to the presence of flavonoids which have remarkable antioxidant and anti-inflammatory activity. HIGHLIGHTS Liver disorders are the most common health hazard found in developing countries due to dietary habits, alcohol ingestion, poor hygiene, unsupervised drug use and smoking. Liver diseases can be non-inflammatory, inflammatory and degenerative Acalypha indica is one of the weed plants that contain important medicinal values for human health applications In vitro study of methanolic leaf extract of Acalypha indica against CCl4 induced hepatic damage in goat liver slice culture proven its efficacy against liver diseases GRAPHICAL ABSTRACT

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Hindrawan, Yanto, Rina Priastini Susilowati, and Monica Puspa Sari. "Tinjauan Pustaka: Kajian in Vivo dari Obat Luka Kulit Berbahan Acalypha Indica, Aloe Vera, dan Centella Asiatica." Jurnal Kedokteran Meditek 27, no. 1 (2021): 73–80. http://dx.doi.org/10.36452/jkdoktmeditek.v27i1.1928.

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Luka merupakan gangguan pada sel dan jaringan anatomi yang dapat disebabkan oleh beberapa hal baik disengaja maupun tidak disengaja. Luka terutama pada kulit jika tidak diobati dengan baik maka dapat menimbulkan infeksi. Hal ini disebabkan oleh proses penyembuhan luka yang kompleks dan dinamis. Proses ini memerlukan bantuan berupa obat yang terbuat dari bahan sintesis ataupun alami. Tinjauan pustaka ini ditulis dengan tujuan untuk mengevaluasi kemanjuran tiga tanaman obat yang sering digunakan untuk mengobati luka, yaitu Acalypha indica, Aloe vera , dan Centella asiatica. Penelusuran dan penapisan pustaka di lakukan dengan Proquest, Pubmed dan Google Scholar dengan kata kunci wound healing AND Acalypha indica OR Centella asiatica OR wound healing OR Aloe vera. Sebanyak 25 makalah dipilih untuk penulisan tinjauan pustaka ini. Acalypha indica, Aloe vera , dan Centella asiatica merupakan tanaman obat yang efektif untuk mengobati luka luar. Hal in telah dibuktikan dalam berbagai studi in vivo bahwa ekstrak tanaman herbal ini memiliki efektivitas yang baik untuk menyembuhkan luka dibandingkan obat medis. Penggunaa tanaman herbal untuk pengobatan juga dianggap lebih murah, aman, mudah didapat dan diolah. Acalypha indica, Aloe vera dan Centella asiatica merupakan tanaman obat yang efektif untuk mengobati luka luar.

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Astuti, Luluk Tri, Rahmi Sugihartuti, Lianny Nagoi, Nunuk Dyah Retno Lastuti, Dewa Ketut Meles, and Agus Sunarso. "The Potential of Anting – Anting (Acalypha indica L.) Leaf Extract as Anti-Scabies to Sarcoptes scabiei var. Cuniculi in vitro." Journal of Parasite Science 3, no. 2 (2019): 67. http://dx.doi.org/10.20473/jops.v3i2.16520.

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The Aim of research to determine the potential of anting-anting (Acalypha indica L.) leaf extract as anti-scabies to Sarcoptes scabiei var. Cuniculi in vitro by observing the mortality rates and lethal concentration of Sarcoptes scabiei. There were 5 treatments namely DMSO 0.5% (PN). Amitraz (P0), anting-anting (Acalypha indica L.) leaf extract concentratrion of 6,25% (P1), 12,5% (P2) and 25% (P3). Observations were carried out for 8 hours with stereomicroscope. The data was analyzed using rpobit analysis with SPSS 20.0 software. The results showed that the fastest mortality rate of S. Scabiei was group p3 at 4.6 mites/hour., then P0, P2, P1 and PN respectively 3.5, 3.1, 1.9, and 1.3 mites/ hour. The smallest concentration of anting-anting (Acalypha indica L.) leaf extract was not significantly different compared to amitraz for killing of 50% and 90% S. Scabiei was 12.5% with lethal time (LT50) 1.82 hours and (LT90) 3.69 hours. In conclusion, anting-anting (Acalypha indica L.) leaf extract has mortality rate against S. Scabiei var. Cuniculi of 3.1 mites/hour, lethal concentration of 12.5% and potential as anti-scabies in vitro.

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Rajasekar P, Jebanesan A, Mohamed Shamsudin, et al. "Ovicidal response effects of selected plant essential oils against Aedes aegypti." JOURNAL OF ADVANCED APPLIED SCIENTIFIC RESEARCH 1, no. 5 (2021): 1–3. http://dx.doi.org/10.46947/joaasr15201631.

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The ovicidal response of selected plant essential oils was evaluated under laboratory conditions against Aedes aegypti. Three plant oils viz., Abutilon indicum, Acacia nilotica and Acalypha indica were tested for ovicidal response assays at six different concentrations viz., 75, 125, 175, 225, 275 and 325 ppm concentrations. The ovicidal activity degreasing of essential oils against Aedes aegypti were Acacia nilotica > Acalypha indica and Abutilon indicum.

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Silalahi, Marina. "Acalypha Indica: Pemanfaatan dan Bioaktivitasnya." Titian Ilmu: Jurnal Ilmiah Multi Sciences 11, no. 2 (2019): 81–86. http://dx.doi.org/10.30599/jti.v11i2.478.

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Acalypha indica (AI) atau yang dikenal dengan nama daun anting-anting telah lama digunakan masyarakat Indonesia sebagai obat tradisional. Pemanfaatan tumbuhan sebagai obat tradisional berhubungan dengan kandungan metabolit sekunder dan bioaktivitasnya. Penulisan artikel ini didasarkan pada kajian literatur yang diperoleh dari jurnal ilmiah yang terbit secara online maupun offline, sehingga diperoleh informasi yang komprehensif mengenai bioaktivitas AI. Sebagai obat tradisional AI digunakan untuk obat kolesterol dan rematik. Kandungan metabolit sekunder AI berupa saponin, flavonoid, steroid, fenol, alkaloid, tanin, dan glikosida jantung. Bioaktivitas AI antara lain: anti mikroba, antioksidan, anti diabetes melitus, anti kanker, anti stroke dan meningkatkan kualitas sperma. Aktivitas anti mikroba AI berhubungan dengan kandungan flavonoid dan alkaloid. Mikroba merupakan salah satu penyebab keracunan makanan, oleh karena itu bioaktivitasnya AI sebagai anti mikroba berpotensi sebagai pengawet makanan.

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Dini Afriliza, Rina Herowati, and Ana Indrayati. "Network Pharmacology Approach to Acalypha indica L. and Plumbago zeylanica L. As Anti-Rheumatoid Arthritis Candidates." JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA 11, no. 2 (2024): 204–18. https://doi.org/10.20473/jfiki.v11i22024.204-218.

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Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease that can reduce quality of life. Currently, the goal of therapy is to achieve remission and prevent joint damage and disability. Acalypha indica L. and Plumbago zeylanica L. are known to be involved in rheumatoid pathogenesis. Objective: This study aimed to determine the compounds in Acalypha indica L. and Plumbago zeylanica L. that correlate with target proteins and anti-rheumatoid arthritis mechanisms. Methods: Plant compound data were collected from the KNApSAcK and IMPPAT databases, target protein data were collected using the KEGG pathway, validated using UniProt, and protein-protein interactions were analyzed using STRING. Target protein prediction using SwissTarget Prediction and SEA. Visualization of network pharmacology profiles using Cytoscape software based on the correlation between plant compounds and target proteins. Results: Acalypha indica L., which correlates with target proteins, contained quinine, gallotannin, 1,4 benzoquinone, chrysin, and kaempferol. For Plumbago zeylanica L., the compounds were vanillic acid, cinnamic acid, plumbagin, isoaffinetin, isoorientin, isovitexin, methylnaphthazarin, l-tryptophan, beta-sitosterol, stigmasterol, ficusin, suberosin, and quercetin 3-ol-rhamnoside. Conclusion: Network pharmacology visualization results showed that both Acalypha indica L. and Plumbago zeylanica L. correlated with disease target proteins in their respective rheumatoid arthritis signaling pathways.

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Montero-Muñoz, Iris, Geoffrey A. Levin, and José M. Cardiel. "Four new species of Acalypha L. (Euphorbiaceae, Acalyphoideae) from the West Indian Ocean Region." PhytoKeys 140 (February 24, 2020): 57–73. http://dx.doi.org/10.3897/phytokeys.140.50229.

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Four new species of Acalypha (Euphorbiaceae, Acalyphoideae) from the Western Indian Ocean Region, based on morphological and molecular evidence, are described, illustrated, and mapped. Acalypha gillespieae sp. nov., A. leandrii sp. nov. and A. nusbaumeri sp. nov. are endemic to Madagascar, and A. mayottensis sp. nov. is known only from Mbouzi islet (Mayotte), in the Comoros Archipelago. We also describe for the first time in Acalypha the presence of membranous or chartaceous perules covering the axillary buds. Preliminary conservation assessments of the new species are also provided.

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Montero-Muñoz, Iris, Geoffrey A. Levin, and José M. Cardiel. "Four new species of Acalypha L. (Euphorbiaceae, Acalyphoideae) from the West Indian Ocean Region." PhytoKeys 140 (February 24, 2020): 57–73. https://doi.org/10.3897/phytokeys.140.50229.

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Four new species of Acalypha (Euphorbiaceae, Acalyphoideae) from the Western Indian Ocean Region, based on morphological and molecular evidence, are described, illustrated, and mapped. Acalypha gillespieae sp. nov., A. leandrii sp. nov. and A. nusbaumeri sp. nov. are endemic to Madagascar, and A. mayottensis sp. nov. is known only from Mbouzi islet (Mayotte), in the Comoros Archipelago. We also describe for the first time in Acalypha the presence of membranous or chartaceous perules covering the axillary buds. Preliminary conservation assessments of the new species are also provided.

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Solihah, Riyadatus, Rizal Umar Rahmadani, and Metta Kristina. "Effect Of Anting-Anting Leaf Extract (Acalypha Indica L.) On Lowering Blood Glucose Rats (Rattus Norvegicus) Induced By Sukrosa." Journal of Scientific Research, Education, and Technology (JSRET) 3, no. 2 (2024): 692–97. http://dx.doi.org/10.58526/jsret.v3i2.399.

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Anting-anting leaves (Acalypha indica L.) are weeds that have various properties, one of which is as a lowering blood glucose levels. The chemical content contained in the form of flavonoids that function as inhibitors of α-glucosidase, maltase, α-amylase enzymes, tannin substances are also known to function as astrigents that can inhibit glucose intake is not excessive. The purpose of this study is to determine whether there is an effect of anting-anting leaf extract (Acalypha indica L.) on reducing blood glucose levels in rats (Rattus norvegicus) induced by sucrose. This research used 20 rats (Rattus norvegicus) as test animals which were divided into 5 groups. The group consisted of negative control group, positive control and 3 dose groups. The doses used were 500 mg/kgBB, 1000 mg/kgBB and 1200 mg/kgBB. Mice were made hyperglycemia with sucrose induction which was then given anting-anting leaf extract (Acalypha indica L.) according to lower glucose levels in mice. The results obtained were continued with the two-way ANOVA test and obtained significant results indicated by p < 0.05 (0.005) which showed there was a significant effect of anting-anting leaf extract (Acalypha indica L.) on reducing blood glucose levels in sucrose-induced rats (Rattus norvegicus). Significant results were continued with the post hoc test and obtained significant results.

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Jancy, Mary E., and L. Inbathamizh. "Phytochemistry and Pharmacology of Five Traditionally Valuable Herbal Plants: A Review." Research Journal of Biotechnology 17, no. 3 (2022): 141–72. http://dx.doi.org/10.25303/1703rjbt141172.

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Herbal plants are used by traditional medical practitioners for the treatment of various diseases. The present review summarizes information about the phytochemistry, biological properties, traditional and medicinal uses of five herbal plants: Plectranthus amboinicus (Indian Borage), Ocimum tenuiflorum (Holy Basil), Mentha piperita (Peppermint), Trigonella foenum-graecum (Fenugreek) and Acalypha indica (Indian Acalypha). The therapeutic uses of plants are considered inexpensive and efficient due to their ease of availability and wide range of biological activities. These herbs are used in medicine for the treatment of various disorders such as asthma, flu, eczema and cardiovascular disorders. They possess medicinal properties and are pharmacologically beneficial through their antioxidant, antimicrobial, antibacterial, antiviral, antifungal, anti-inflammatory, antidiabetic, anticancer, analgesic, antimalarial, antibiofilm, antidiuretic, wound healing activity, skincare, hepatoprotective and hypolipidemic activities. This is due to the presence of various secondary metabolites such as flavonoids, terpenoids, glycosides, phenols, alkaloids, tannins and steroids which have been identified through various spectroscopic methods. The different parts of these herbs have been used to prepare medicines. Due to the presence of various important phytochemicals, they are used in food, nutrition and medicine without side effects. These further find applications in drug discovery, novel drug development, nanodiagnostics and nanotherapy.

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Aghade, Karveer, Uttara Joshi, Ashish Kandalkar, and Ramdas Pandhare. "Invitro Evaluation of Ethanolic extract of Acalypha Indica Linn. Leaves for Antilithiatic Activity." YMER Digital 21, no. 07 (2022): 132–43. http://dx.doi.org/10.37896/ymer21.07/10.

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To give scientific background to the above traditional claim, the aerial parts of Acalypha Indica Linn. were evaluated for its antilithiatic activity. In the present study, aerial parts of Acalypha Indica Linn. were subjected to morphological, microscopically, phytochemical investigations and evaluated for in vivo antilithiaticactivity. The plant material after defatting with pet. Ether (60-80) extracted with ethanol and then fractionated with chloroform, ethyl acetate and n-butanol. Qualitative chemical examination of various extracts revealed the presence of Alkaloids, Steroids, Flavonoids, Glycosides, Tannins, and Carbohydrates. Acute toxicity studies were carried out as per OECD guidelines and the doses were fixed at 200 mg/kg b.w. and 400 mg/kg b.w. The Ethanolic extract was evaluated for in vivoantilithiatic activity by using CCl4 induced antilithiatic model. The ethanolic extract showed better effect at the dose of 10 mg/kg b.w in lowering elevated level of kidney stones in the kidney. Keywords: - Acalypha indica Linn, Phytochemical, antilithiatic, Ethanolic extract

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Montero-Muñoz, Iris, Geoffrey A. Levin, Concepción Vaquero Lorenzo, Laura González, and José M. Cardiel. "Novelties in the genus Acalypha (Euphorbiaceae, Acalyphoideae): two new species from northern Madagascar." Plant Ecology and Evolution 156, no. 3 (2023): 365–73. http://dx.doi.org/10.5091/plecevo.108024.

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Background and aims – Taxonomic knowledge of Acalypha in the Western Indian Ocean Region (WIOR; including Madagascar, Comoros, Mascarenes, Seychelles, and the Scattered Islands) has increased greatly in the last few years. This paper is the latest in a series of publications that have contributed to create a robust taxonomic framework for Acalypha in this region. Material and methods – The descriptions and illustrations of the new species are based on herbarium specimens and on some field images. Descriptions were made following standard procedures. Maps was prepared using QGIS software and preliminary conservation assessments was made following IUCN guidelines and criteria. Key results – Two species of Acalypha from northern Madagascar are described as new to science: Acalypha bardotiana sp. nov., found on the Montagne des Français (Diana region), and Acalypha inaequibracteata sp. nov., found in the Binara forest (Sava region). Line drawings, field images, distribution maps, and a discussion of their morphological and phylogenetic affinities, as well as the preliminary conservation assessments are provided.

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M., B. Patil, and A. Khan P. "ETHNOMEDICINAL STUDIES OF ACALYPHA INDICA L. (EUPHORBIACEAE)." Review Of Research 4, no. 7 (2015): 1–6. https://doi.org/10.5281/zenodo.7559024.

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The present work deals with review of ethno botanical uses of Acalypha indica L. family Euphorbiaceae is commonly known as Kupi, Khokali. The plant has been used widely by traditional practitioners for the treatment of various diseases. The Leaves, root, stalks (young shoots) and flowers are used in medicine. It has Cathartic, Anthelmintic, expectorant, emetic, anodyne and hypnotic properties. The therapeutic properties of Acalypha in Ayurveda and Siddha texts are discussed in detail in this article. The plants also used in the treatment of domestic animals.

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SIVALINGAM, SIVAKUMAR, JYOTI KAVIRAJWAR, K. SEETHALAKSHMI, R. KAYALVIZHI, and M. NAGOOR MEERAN AND R. NAGALAKSHMI. "Green Synthesis and Characterization of Calcium Oxide Nanoparticles from Acalypha indica Leaves Extract: Their Antimicrobial Activity." JOURNAL OF ENVIRONMENT AND BIO-SCIENCE 38, no. 02 (2024): 311. https://doi.org/10.59467/jebs.2024.38.311.

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This study is focused on synthesizing calcium oxide nanoparticles (CaO NPs) using Acalypha indica leaf extract in an eco-friendly way. CaO NPs s obtained were characterized by ultraviolet-visible spectroscopy, Fourier transform infrared, X-ray diffraction, and scanning electron microscopy studies. Their antibacterial activity was screened using the Kirby-Bauer disk diffusion method. Results confirmed the significant antibacterial activity of CaO Nps against various strains of bacteria like Bacillus subtilis, Staphylococcus aureus, Salmonella typhi, and Escherichia coli. . KEYWORDS :Acalypha indica, Calcium oxide nanoparticles, Diffusion, Green synthesis

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Suhesti, Iin, Anisa Hariyani, Aisyah Nur Hidayah, and Arofah Frisca Sahara. "POTENSI PENGGUNAAN TANAMAN ANTING-ANTING (Acalypha indica L) SEBAGAI ZAT AKTIF PADA PEMBUATAN LIP BALM DAN SEDIAAN KOSMETIK LAINNYA." Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat 4, no. 2 (2020): 7–11. http://dx.doi.org/10.46808/farmasindo.v4i2.37.

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Lip balm merupakan salah satu produk kosmetik yang paling sering digunakan saat ini, terutama oleh kaum wanita. Tujuan penggunaan lip balm yaitu untuk melembabkan bibir dan mengurangi bibir pecah-pecah. Tetapi banyak sediaan lip balm yang menggunakan bahan kimia berbahaya sehingga dapat mengakibatkan bibir menjadi hitam, iritasi sampai ke kanker kulit, sehingga diperlukan lip balm yang menggunakan zat aktif dari bahan alam salah satunya adalah tanaman Anting-anting (Acalypha indica L). Penelitian ini dilakukan dengan metode narative review yang bertujuan untuk mengetahui potensi penggunaan tanaman anting-anting (Acalypha indica L) sebagai zat aktif pada pembuatan lip balm dan sediaan kosmetik lainnya. Hasil dari beberapa literatur diperoleh golongam flavonoid yang berhasil diidentifikasi dari tanaman anting-anting (Acalypha indica L) adalah isoflavon, flavon, flanolol, flavanon, dihidroksiflavonol, khalkon dan antosianidin. Ditemukan juga kandungan antioksidan dengan persen inhibisi (IC50) menggunakan pelarut etanol fraksi TH, HB, HA secara berturut-turut adalah 127,87 ppm; 132,97 ppm; dan 133,68 ppm dengan kategori sedang. Sedangkan dengan pelarut heksana, kloroform dan methanol diperoleh aktivitas antioksidan yang signifikan dengan nilai IC50 yaitu 6,19 ± 0,010 mg/ml; 5,70 ± 0,050 mg/ml; dan 7,79 ± 0,020 mg/ml. Kadar antioksidan pada daun dengan konsentrasi 200, 400, dan 600 μg yaitu 17,12%; 26,87%; dan 31,14%. Sedangkan pada akar dengan konsentrasi 200, 400, dan 600 μg yaitu 26,16%; 41,84%; dan 53,27%. Berdasarkan kandungan flavonoid dan antioksidan, tanaman anting-anting (Acalypha indica L) berpotensi sebagai zat aktif pada pembuatan lip balm dan sediaan kosmetik lainnya.

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Montero Muñoz, Iris, José María Cardiel, and Geoffrey A. Levin. "Nomenclatural review of Acalypha (Euphorbiaceae) of the Western Indian Ocean Region (Madagascar, the Comoros Archipelago, the Mascarene Islands and the Seychelles Archipelago)." PhytoKeys 108 (September 10, 2018): 85–116. http://dx.doi.org/10.3897/phytokeys.108.27284.

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This work presents a critical nomenclatural review of the Acalypha species of the Western Indian Ocean Region (Madagascar, the Comoros Archipelago, the Mascarene Islands and the Seychelles Archipelago). This is the first treatment of Acalypha of Madagascar since Leandri’s monograph in 1942. A total of 151 scientific names related to Acalypha from this region are treated. We recognise 35 species (28 native and seven introduced), treat 93 names as synonyms (28 of them for the first time) and identify three as doubtful or excluded names. We designate lectotypes for 41 names, make two new combinations and propose one new name.

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Journal articles on the topic 'Acalypha india'

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