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Journal articles on the topic 'Acanthosis nigricans- AN'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Callanan, Niamh, and Neil Wright. "Single-centre case–control study investigating the association between acanthosis nigricans, insulin resistance and type 2 diabetes in a young, overweight, UK population." BMJ Paediatrics Open 6, no. 1 (2022): e001574. http://dx.doi.org/10.1136/bmjpo-2022-001574.

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ObjectiveTo determine the extent to which the presence of acanthosis nigricans confers additional risk for insulin resistance, in addition to obesity alone (body mass index, BMI) within a young, overweight, UK population.Research design and methodsRetrospective data were collected to compare the degree of insulin resistance within a sample of 94 young people with acanthosis nigricans, and a matched cohort of 94 participants with obesity alone. Insulin resistance was assessed by fasting glucose, fasting insulin and Homeostatic Model Assessment of insulin resistance (HOMA-IR) score (a mathematic

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2

Doležel, Zdeněk, Jana Šťastná, Jan Papež, and Petra Konečná. "Acanthosis nigricans." Pediatrie pro praxi 21, no. 1 (2020): 54–55. http://dx.doi.org/10.36290/ped.2020.005.

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3

Gibson, Lawrence E. "Acanthosis Nigricans." Mayo Clinic Proceedings 79, no. 12 (2004): 1571. http://dx.doi.org/10.4065/79.12.1571.

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4

Fargnoli, Maria Concetta, and Pasquale Frascione. "Acanthosis Nigricans." New England Journal of Medicine 353, no. 26 (2005): 2797. http://dx.doi.org/10.1056/nejmicm050300.

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5

Schwartz, Robert A. "Acanthosis nigricans." Journal of the American Academy of Dermatology 31, no. 1 (1994): 1–19. http://dx.doi.org/10.1016/s0190-9622(94)70128-8.

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6

Vinzio, S., F. Luca, B. Cribier, and J. L. Schlienger. "Acanthosis nigricans." Médecine des Maladies Métaboliques 3, no. 5 (2009): 519. http://dx.doi.org/10.1016/s1957-2557(09)73301-2.

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7

De Schepper, S., and J. M. Naeyaert. "Acanthosis nigricans." EMC - Dermatologie 1, no. 1 (2006): 1–7. http://dx.doi.org/10.1016/s0246-0319(06)41636-8.

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8

Matsuoka, Lois Y., Jacobo Wortsman, and Jose Goldman. "Acanthosis nigricans." Clinics in Dermatology 11, no. 1 (1993): 21–25. http://dx.doi.org/10.1016/0738-081x(93)90076-o.

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9

Sedano, Heddie O., and Robert J. Gorlin. "Acanthosis nigricans." Oral Surgery, Oral Medicine, Oral Pathology 63, no. 4 (1987): 462–67. http://dx.doi.org/10.1016/0030-4220(87)90259-3.

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10

Marimuthu, S., and B. S. Menon. "Acanthosis nigricans." Archives of Disease in Childhood 94, no. 6 (2009): 477. http://dx.doi.org/10.1136/adc.2008.155713.

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11

Rappoport, Lisa, Thomas Jansen, Joachim Dissemond, et al. "Acanthosis nigricans." hautnah dermatologie 26, no. 2 (2010): 72–74. http://dx.doi.org/10.1007/bf03358021.

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12

Holdiness, M. R. "Acanthosis nigricans." Archives of Dermatology 121, no. 5 (1985): 588b—588. http://dx.doi.org/10.1001/archderm.121.5.588b.

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13

Holdiness, Mack R. "Acanthosis Nigricans." Archives of Dermatology 121, no. 5 (1985): 588. http://dx.doi.org/10.1001/archderm.1985.01660050036005.

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14

Mazer, Jean-Michel. "Acanthosis nigricans." EMC - Dermatologie 1, no. 4 (1999): 1–9. https://doi.org/10.1016/s0246-0319(19)30036-6.

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15

Kumar, Piyush, Rajesh Kumar, Shahid Hassan, Vikas Anand, and Anupam Das. "Acral acanthosis nigricans (acral acanthotic anomaly)." Indian Dermatology Online Journal 5, no. 6 (2014): 140. http://dx.doi.org/10.4103/2229-5178.146201.

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16

Schwartz, Robert A. "Acral acanthosis nigricans (acral acanthotic anomaly)." Journal of the American Academy of Dermatology 56, no. 2 (2007): 349–50. http://dx.doi.org/10.1016/j.jaad.2006.09.027.

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17

Noviarti, Dini, Eka Agustia Rini, and Fadil Oenzil. "Association of resistin level with acanthosis nigricans in obese adolescents." Paediatrica Indonesiana 56, no. 1 (2016): 32. http://dx.doi.org/10.14238/pi56.1.2016.32-6.

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Background Childhood obesity is associated with increased risk of cardiovascular diseases and metabolic syndrome, such as insulin resistance. Clinically, insulin resistance may be manifested as acanthosis nigricans. Resistin has a biological activity that is important in glucose and lipid metabolisms and closely related to the incidence of insulin resistance.Objective To find out the association of resistin level with scale of acanthosis nigricans in adolescents obesity.Methods A cross-sectional study was conducted on 53 obese adolescents with acanthosis nigricans in senior high schools in Pad

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18

Daye, Munise, Beray Selver Eklioglu, and Mehmet Emre Atabek. "Relationship of acanthosis nigricans with metabolic syndrome in obese children." Journal of Pediatric Endocrinology and Metabolism 33, no. 12 (2020): 1563–68. http://dx.doi.org/10.1515/jpem-2020-0154.

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AbstractObjectivesAcanthosis nigricans is a skin symptom in obesity that helps to identify patients at high risk for dyslipidemia, hypertension, insulin resistance, and diabetes. It is the most important complication of obesity in metabolic syndrome. Studies investigating the relationship between acanthosis nigricans and metabolic syndrome in obese children are insufficient. In our study, the relationship of acanthosis nigricans and metabolic syndrome was evaluated in children.MethodsObese children aged between 6 and 18 years old, who were examined in the pediatric endocrinology outpatient cli

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19

Yadav, Priyanka Yogananda, Mukunda Ranga Swaroop, Nikitha Reddy, Shaikh Mohammed Obeidullan, Tarandeep Kaur Kalra, and Shaila Shree Devendra. "Clinicoepidemiological study of acanthosis nigricans in pre and primary school children and its association with body mass index, waist circumference and insulin resistance." IP Indian Journal of Clinical and Experimental Dermatology 8, no. 3 (2022): 152–61. http://dx.doi.org/10.18231/j.ijced.2022.033.

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Acanthosis nigricans is characterised by hyperpigmentation and velvet like thickening of skin. It is seen symmetrically involving the neck, axilla, groins, antecubital and popliteal fossae, umbilical, perianal areas and in advanced conditions, even dorsum of hands and fingers.To evaluate the clinical features and epidemiological factors of acanthosis nigricans in pre and primary school children and to evaluate the association of acanthosis nigricans with body mass index, waist circumference and insulin resistance. A total of 100 children with acanthosis nigricans meeting defined inclusion and

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20

Mustafa, Manal, Nabil Moghrabi, and Bassam Bin-Abbas. "Hypochondroplasia, Acanthosis Nigricans, and Insulin Resistance in a Child with FGFR3 Mutation: Is It Just an Association?" Case Reports in Endocrinology 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/840492.

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FGFR3 mutations cause wide spectrum of disorders ranging from skeletal dysplasias (hypochondroplasia, achondroplasia, and thanatophoric dysplasia), benign skin tumors (epidermal nevi, seborrhaeic keratosis, and acanthosis nigricans), and epithelial malignancies (multiple myeloma and prostate and bladder carcinoma). Hypochondroplasia is the most common type of short-limb dwarfism in children resulting from fibroblast growth factor receptor 3 (FGFR3) mutation. Acanthosis nigricans might be seen in severe skeletal dysplasia, including thanatophoric dysplasia and SADDAN syndrome, without a biochem

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21

Choudhary, Sanjiv V., Vikrant Saoji, Adarshlata Singh, and Shivani Mane. "Acanthosis nigricans: a clinical marker of insulin resistance." International Journal of Research in Dermatology 3, no. 2 (2017): 161. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20171497.

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<p><strong>Background:</strong> Very little information is available regarding the association of acanthosis nigricans with insulin resistance from rural areas of India. Therefore this study was carried out with the aim and objectives to study the association between acanthosis nigricans and insulin resistance and to evaluate correlation of acanthosis nigricans severity, neck severity and neck texture severity with fasting blood sugar &amp; serum insulin especially in this rural part of central India.</p><p><strong>Methods:</strong> In this cross s

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22

Butt, Nauman Ismat, Khalid Mahmood, Nimra Kanwal, and Fahmina Ashfaq. "Acanthosis Nigricans in Patients with Type II Diabetes Mellitus at a Tertiary Care Hospital of Lahore." Journal of Bahria University Medical and Dental College 13, no. 01 (2022): 13–17. http://dx.doi.org/10.51985/jbumdc202266.

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Objective: Acanthosis Nigricans is characterized by skin thickening with hyperpigmentation dermatosis predominantly seen on flexural aspects & nape of neck. The objective of present study was to determine frequency of Acanthosis Nigricans among patients of type II diabetes mellitus. Study Design and Setting: This observational cross-sectional study was undertaken at Department of Medicine Azra Naheed Medical College, Superior University Lahore from August 2021 to April 2022. Methodology: Type II diabetes mellitus was defined as patients with HbA1c 7.0%, or two blood glucose random readings

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23

Das, JayantaKumar, Sujata Sengupta, and Asok Gangopadhyay. "Nevoid acanthosis nigricans." Indian Journal of Dermatology, Venereology and Leprology 74, no. 3 (2008): 279. http://dx.doi.org/10.4103/0378-6323.41392.

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24

Turan, Enver, Yavuz Yeşilova, and Sezen Koçarslan. "Nevoid Acanthosis Nigricans." Turkish Journal of Dermatology / Türk Dermatoloji Dergisi 8, no. 3 (2014): 176–77. http://dx.doi.org/10.4274/tdd.2017.

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25

Taylor, G., M. P. James, and H. Simpson. "Familial Acanthosis Nigricans." Journal of the Royal Society of Medicine 87, no. 3 (1994): 169. http://dx.doi.org/10.1177/014107689408700319.

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26

Павлов, Стоян. "Acanthosis nigricans benigna." Редки болести и лекарства сираци 12, no. 2 (2021): 15–18. http://dx.doi.org/10.36865/2021.v12i2.140.

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Acanthosis nigricans (AN) е рядко вродено или придобито вторично кожно заболяване, характеризиращо се с потъмняване (хиперпигментация) и удебеляване (хиперкератоза) на кожата. Ангажирани са симетрично гънките: в подмишницата (аксилата), слабините и задната част на врата. Подразделя се на доброкачествен („pseudoacanthosis nigricans“) и злокачествен AN. Представя се случай на 43-годишна жена с AN – симетрични пигментирани плаки с папиломатозна повърхност в аксилите, тила, гърба на ходилата, на фона на клинични прояви на обезитас IІІ степен (ИТМ > 40 кг/м2) и инсулинорезистентен диабет с

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27

Schnopp, Christina, and Julia Baumstark. "Oral Acanthosis Nigricans." New England Journal of Medicine 357, no. 9 (2007): e10. http://dx.doi.org/10.1056/nejmicm062917.

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28

Wedge, Charlotte C. I., David S. Rootman, William Hunter, and Garry Sibbald. "Malignant Acanthosis Nigricans." Ophthalmology 100, no. 10 (1993): 1590–92. http://dx.doi.org/10.1016/s0161-6420(93)31439-9.

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29

DHAR, SANDIPAN, GOUTAM DAWN, AMRINDER J. KANWAR, and RITAMBHARA NADA. "FAMILIAL ACANTHOSIS NIGRICANS." International Journal of Dermatology 35, no. 2 (1996): 126–27. http://dx.doi.org/10.1111/j.1365-4362.1996.tb03278.x.

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30

Ozhan, Bayram, Sebahat Yilmaz Agladioglu, Selcuk Yuksel, and Berna Sanli. "Perioral Acanthosis nigricans." Journal of Pediatrics 167, no. 6 (2015): 1453. http://dx.doi.org/10.1016/j.jpeds.2015.08.046.

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31

Das, Anupam, Priyankar Misra, and Saumya Panda. "Childhood acanthosis nigricans." Indian Journal of Paediatric Dermatology 20, no. 3 (2019): 199. http://dx.doi.org/10.4103/ijpd.ijpd_34_18.

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32

Hall, J. Michael, Adele Moreland, Gregory J. Cox, Thomas R. Wade, and Brad Neville. "Oral Acanthosis Nigricans." American Journal of Dermatopathology 10, no. 1 (1988): 68–73. http://dx.doi.org/10.1097/00000372-198802000-00009.

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33

Sinha, Smeeta, and Robert A. Schwartz. "Juvenile acanthosis nigricans." Journal of the American Academy of Dermatology 57, no. 3 (2007): 502–8. http://dx.doi.org/10.1016/j.jaad.2006.08.016.

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34

Lenzner, Ursula, Julia Ramsauer, Wiebke Petzoldt, and Wilhelm Meigel. "Acanthosis nigricans maligna." Der Hautarzt 49, no. 1 (1998): 41–47. http://dx.doi.org/10.1007/s001050050699.

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35

Valejo Coelho, Margarida Moura, Joanna Prokop, and Cândida Fernandes. "Acanthosis Nigricans Maligna." JAMA Dermatology 155, no. 9 (2019): 1069. http://dx.doi.org/10.1001/jamadermatol.2019.1127.

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36

Wang, Huei-Jing, and S. Chu-Sung Hu. "Malignant Acanthosis Nigricans." New England Journal of Medicine 388, no. 11 (2023): 1031. http://dx.doi.org/10.1056/nejmicm2207017.

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37

Noguez, Bonifacio Caballero, Marco A. Cardoso-Gomez, María L. Ponce-Lopez, Antonio Mendez Duran, and Ulises Reyes Gomez. "Blood glucose levels in children with acanthosis nigricans associated with obesity." International Journal of Contemporary Pediatrics 7, no. 12 (2020): 2255. http://dx.doi.org/10.18203/2349-3291.ijcp20204941.

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Background: A body mass index ≥95 percentile increases 40 times the risk of diabetes. The hyperinsulinemia secondary to the resistance of insulin and obesity is associated to the development of acanthosis nigricans. The objective of current study was to associate acanthosis nigricans with childhood obesity with alterations in the curve of glucose tolerance.Methods: In current study 90 children were evaluated with obesity and acanthosis nigricans of which only 34 concluded the study. Glucose, cholesterol and triglycerides levels were determined while in fasting state, and glucose tolerance curv

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38

Kluczynik, Caroline Evelin Nascimento, Larissa Soares Mariz, Larissa Camila Ferreira Souza, Gabriela Beserra Solano, Fernanda Cruz de Lira Albuquerque, and Carla Campos Muniz Medeiros. "Acanthosis nigricans and insulin resistance in overweight children and adolescents." Anais Brasileiros de Dermatologia 87, no. 4 (2012): 531–37. http://dx.doi.org/10.1590/s0365-05962012000400002.

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BACKGROUND: Studies have suggested an association between the presence of acanthosis nigricans (AN) and the development of diabetes. OBJECTIVE: To investigate the association between AN and insulin resistance (IR) in overweight children and adolescents receiving care at the Center for Childhood Obesity, Campina Grande, PB. METHODS: This cross-sectional study was conducted between April 2009 and April 2010 including 194 individuals of 2 to 18 years of age receiving care within the Brazilian national health network. The presence of acanthosis nigricans was verified and anthropometric measurement

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39

Gautam, Manjyot, Sejal Kumar, and Vedant Ghuse. "Nevoid Acanthosis Nigricans - A rare case and successful treatment using fractional CO₂ laser." Indian Journal of Postgraduate Dermatology 1 (February 7, 2023): 54–56. http://dx.doi.org/10.25259/ijpgd_42_2022.

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Nevoid acanthosis nigricans is a rare variant of acanthosis nigricans that may develop at birth or before puberty. An 18-year-old boy with a lean built presented with asymptomatic hyperpigmented lesion on the left lateral aspect of the trunk since 15 years of age. There was no systemic involvement. The diagnosis of unilateral nevoid acanthosis nigricans variant was made which was confirmed by dermoscopy and histopathology.

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40

Sivadas, S., K. Rao, V. Ajila, and Y. Jain. "Lelis Syndrome: Unveiling a Rare Phenomenon." Acta Medica Bulgarica 52, s1 (2025): 31–34. https://doi.org/10.2478/amb-2025-0021.

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Abstract Background Lelis Syndrome is a rare hereditary disorder, distinguished by the coexistence of acanthosis nigricans and ectodermal dysplasia with a recessive mode of inheritance. Clinical characteristics seen are hypodontia, perioral and periorbital hyperpigmentation, leukoderma, palmoplantar hyperkeratosis, nail dystrophy, and intellectual disability. Clinical case description A male patient in his 30s who was initially diagnosed with acanthosis nigricans was referred to the authors’ department for dental evaluation and opinion. The patient manifested features of Ectodermal Dysplasia w

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41

Mørk, NJ, G. Rajka, and J. Halse. "Treatment of acanthosis nigricans with etretinate (Tigason) in a patient with Lawrence-Seip syndrome (generalized lipodystrophy)." Acta Dermato-Venereologica 66, no. 2 (1986): 173–74. http://dx.doi.org/10.2340/0001555566173174.

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The major symptoms of Lawrence-Seip syndrome or generalized lipodystrophy consist of muscle hypertrophy, loss of subcutaneous fat, hyperlipaemia, diabetes mellitus and acanthosis nigricans. We have successfully treated acanthosis nigricans in a patient with Lawrence-Seip syndrome.

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42

Blume-Peytavi, U., T. Spieker, H. Reupke, and CE Orfanos. "Generalised acanthosis nigricans with vitiligo." Acta Dermato-Venereologica 76, no. 5 (1996): 377–80. http://dx.doi.org/10.2340/0001555576377380.

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We report on a 19-year-old woman with generalised acanthosis nigricans of the inherited type and concomitant vitiligo. Cutaneous velvety thickening of the skin with intensification of skin markings and progressive development of hyperpigmented papillomatous, verrucoid lesions in the body folds started to develop in early childhood. These hyperpigmentations were continuously replaced by a progressive vitiligo, finally leaving most of the acanthosis nigricans lesions completely depigmented. Generalised, pachyderma-like acanthosis nigricans with concomitant vitiligo is an association which to the

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43

Wankhade, VaishaliH, PriyankaA Kowe, and ShashankK Agrawal. "Midline nevoid acanthosis nigricans." Pigment International 9, no. 2 (2022): 141. http://dx.doi.org/10.4103/pigmentinternational.pigmentinternational_20_20.

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44

Jyotsna, VivekaP, Nishant Raizada, Semanti Chakraborty, and S. Pal. "Acanthosis nigricans in insulinoma." Indian Journal of Endocrinology and Metabolism 18, no. 5 (2014): 739. http://dx.doi.org/10.4103/2230-8210.139223.

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45

Pote, A., and PD Cruz. "What causes acanthosis nigricans?" Journal of the European Academy of Dermatology and Venereology 15, no. 4 (2001): 302. http://dx.doi.org/10.1046/j.1468-3083.2001.00244.x.

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46

Pote, A., and PD Cruz. "What causes acanthosis nigricans?" Journal of the European Academy of Dermatology and Venereology 15, no. 4 (2001): 302. http://dx.doi.org/10.1046/j.0926-9959.2001.00244.x.

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47

Krishnaram, A. S. "Unilateral Nevoid Acanthosis Nigricans." International Journal of Dermatology 30, no. 6 (1991): 452–53. http://dx.doi.org/10.1111/j.1365-4362.1991.tb03911.x.

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48

Füeßl, H. S. "Acanthosis nigricans und Hyperandrogenismus." MMW - Fortschritte der Medizin 158, no. 14 (2016): 36. http://dx.doi.org/10.1007/s15006-016-8577-2.

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49

Mondal, Avijit, Panchami Debbarman, and Piyush Kumar. "Generalized benign acanthosis nigricans." Indian Pediatrics 49, no. 10 (2012): 853. http://dx.doi.org/10.1007/s13312-012-0182-6.

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50

Somaï, M., H. Hammami Ghorbel, L. Belhadj, A. Zaouak, and S. Fenniche. "Acanthosis nigricans et insulinorésistance." Annales d'Endocrinologie 77, no. 4 (2016): 519. http://dx.doi.org/10.1016/j.ando.2016.07.816.

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