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Journal articles on the topic 'Accuracy; Precision; Robustness analysis'

Author: Grafiati

Published: 4 June 2021

Last updated: 15 February 2022

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1

Vishnumulaka, Srinivas, Narasimha Rao Medicherla, Allam Appa Rao, and G. Edela Srinubabu. "Development and Validation of LC Method for the Determination of Famciclovir in Pharmaceutical Formulation Using an Experimental Design." E-Journal of Chemistry 5, no. 1 (2008): 58–67. http://dx.doi.org/10.1155/2008/858462.

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A rapid and sensitive RP-HPLC method with UV detection (242 nm) for routine analysis of famciclovir in pharmaceutical formulations was developed. Chromatography was performed with mobile phase containing a mixture of methanol and phosphate buffer (50:50,v/v) with flow rate 1.0 mL min−1. Quantitation was accomplished with internal standard method. The procedure was validated for linearity (correlation coefficient =0.9999), accuracy, robustness and intermediate precision. Experimental design was used for validation of robustness and intermediate precision. To test robustness, three factors were

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Chew, Yik-Ling, Hon-Kent Lee, and Subrahmanya Lokesh Bontha Venkata. "NEW STABILITY INDICATING METHOD FOR ESTIMATION OF PURITY OF FLIBANSERIN ACTIVE PHARMACEUTICAL INGREDIENT." INDIAN DRUGS 57, no. 04 (2020): 40–44. http://dx.doi.org/10.53879/id.57.04.12147.

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Flibanserin has been recently approved by the USFDA for treating female sexual interest disorder. It is currently not included in any of the Pharmacopoeias. No stability indicating method information about flibanserin has been reported in the literature. Flibanserin stock solution (1 mg/mL) was prepared and serially diluted (concentration ranged 1-20 μg/mL). Flibanserin solutions (1-20 μg/mL) were analysed using RP-HPLC under isocratic elution of mobile phase acetonitrile and ammonium acetate (60:40; V/V) at 1 mL/minute. This HPLC method was validated for linearity, accuracy, precision, robust

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Chen, Yu Dong, and S. H. Chen. "Robustness Analysis of Responses of Structures with Uncertain Parameters." Advanced Materials Research 44-46 (June 2008): 303–10. http://dx.doi.org/10.4028/www.scientific.net/amr.44-46.303.

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In the engineering structures, the design parameters may be uncertain because of the manufacture errors and inaccuracy in measurement, etc. The uncertainties of structural parameters may lead to large and unexpected excursion of responses that may lead to drastic reduction in accuracy and precision of the operations. Uncertainties in the design parameters are often considered to ensure that the structure is robust with respect to response errors. The paper discusses the robustness of responses of structures with uncertainties, which are described with three models, the random, convex, and inte

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4

De Souza Barbosa, Fábio, Vanise Coty Rodrigues, Nadia Maria Volpato, et al. "UV SPECTROPHOTOMETRIC METHOD FOR QUANTITATIVE DETERMINATION OF AGOMELATINE IN COATED TABLETS." Drug Analytical Research 1, no. 2 (2017): 24–29. http://dx.doi.org/10.22456/2527-2616.79219.

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UV spectrophotometry is an analytical technique used routinely for qualitative and quantitative assay due the low cost and reliability during analysis. In this work, it was validated a quantitative UV method for determination of agomelatine in coated tablets. The parameters specificity, linearity, precision, accuracy and robustness were evaluated according to official guidelines. Methanol was selected as solvent and the maximum wavelength for drug analysis was 230 nm. The purposed assay showed to be specific and the linearity was proved in a range of 0.5 - 2.5 µg/mL. The RSD values obtained du

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Gomes, Patrícia, Carla M. U. Negretto, Zanandria B. Naisinger, Ricardo Lorenzoni, Nathalie Ribeiro Wingert, and Renata P. Raffin. "Second-derivative spectrophotometry for the analysis of simvastatin in polymeric nanocapsules." Drug Analytical Research 3, no. 2 (2019): 12–17. http://dx.doi.org/10.22456/2527-2616.98057.

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Conventional spectrophotometry methods are very susceptible to the presence of interferences in complex mixtures such as nanoparticules, requiring prior treatment or extraction of the analyte, and not always providing an adequate response. Derivative spectrophotometry method is capable to eliminate its interference; it is an alternative method for drugs determination in complex matrices. This work investigated the utility of derivate spectrophotometry in assay of simvastatin in polymeric nanocapsules (SIVNC). Shimadzu® UV-1650 double-beam spectrophotometer with 1.0 cm quartz cells was used in

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Ghante, Minal R., Akash C. Masale, Supriya G. Jagtap, Sanjay D. Sawant, and Vandana S. Nikam. "SIMPLE, COST EFFECTIVE UV-VIS METHOD FOR ESTIMATION OF ELVITEGRAVIR (EVG) IN PURE AND DOSAGE FORM BY QBD APPROACH AND IN PRESENCE OF MAMMALIAN PLASMA." INDIAN DRUGS 57, no. 01 (2020): 51–58. http://dx.doi.org/10.53879/id.57.01.11738.

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A simple, cost effective, UV-VIS spectrophotometric method for analysis of elvitegravir (EVG) in the presence of plasma was developed to facilitate the assessment of clinical samples or as a routine alternative tool in drug quality control laboratories for quantitative estimation of EVG. The present work delineates the estimation of EVG in 50μl of rat plasma that is directly dissolved in dimethyl sulfoxide (DMSO) and subjected to analysis. Firstly, estimation of EVG in pure and dosage form was developed and validated using analytical quality by design (QbD) as per ICH Q2 (R1), Q8 (R2) guidelin

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Džodić, Predrag Lj, Ljiljana J. ivanovi, Ana D. Proti, Mira L. Zeevi, and Biljana M. Joci. "Determination of Carbamazepine and Its Impurities Iminostilbene and Iminodibenzyl in Solid Dosage Form by Column High-Performance Liquid Chromatography." Journal of AOAC INTERNATIONAL 93, no. 4 (2010): 1059–68. http://dx.doi.org/10.1093/jaoac/93.4.1059.

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Abstract An accurate and precise RP-HPLC method was developed and validated for the determination of carbamazepine and its impurities iminostilbene and iminodibenzyl in a tablet formulation with fluphenazine as an internal standard. Buffermethanol (50 + 50, v/v) was used as the mobile phase. During validation, specificity, linearity, precision, accuracy, LOD, LOQ, and robustness of the method were tested. The method was proven to be specific against placebo interference. Linearity was evaluated over the concentration range of 100500, 0.050.25, and 0.10.5 g/mL, and the r values were 0.9994, 0.9

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8

Marques, Morgana Souza, Fernando Dal Pont Morisso, Fernanda Poletto, and Irene Clemes Külkamp Guerreiro. "Development of derivative spectrophotometric method for simultaneous determination of pyrazinamide and rifampicin in cubosome formulation." Drug Analytical Research 5, no. 1 (2021): 46–50. http://dx.doi.org/10.22456/2527-2616.111454.

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The ultraviolet spectrophotometry analysis for quantitative assay of drugs is a method accurate, sensitive, selective and reproductive with the advantage of being a simple and less expensive method. In this study, a derivative ultraviolet spectrophotometric method was developed for simultaneous determination of pyrazinamide (PYZ) and rifampicin (RIF). The spectrophotometric method was evaluated according to validation guidelines for specificity, linearity, limits of detection and quantification, precision, accuracy and robustness. The first-derivative spectra were obtained and by the zerocross

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9

Rupareliya, Reema H., and Hitendra S. Joshi. "Development and Validation of UV Spectrophotometric Method for Estimation of Agomelatine in Bulk and Pharmaceutical Dosage Form." International Letters of Chemistry, Physics and Astronomy 56 (July 2015): 113–19. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.56.113.

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A simple, rapid, accurate, precise, sensitive and economical UV Spectrophotometric method has been developed for estimation of agomelatine from bulk and pharmaceutical formulation. The λmax of agomelatine in water was found to be 233 nm. The parameters linearity, precision, accuracy, robustness were studied according to International Conference on Harmonization guidelines. The drug follows linearity in the concentration range 2-8μg/ml with correlation coefficient value 0.9981. The accuracy of the method was checked by recovery experiment performed at three different levels i.e., 50%, 100% and

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Rasheed, Anas, and Osman Ahmed. "UPLC Method Optimisation and Validation for the Estimation of Sodium Cromoglycate in Pressurized Metered Dosage Form." INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH 2, no. 02 (2017): 18–24. http://dx.doi.org/10.21477/ijapsr.v2i2.7774.

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UPLC assay method optimised and validated for sodium cromoglycate in metered dose inhaler (MDI) using metronidazoleas an internal standard.The separation of Sodium Cromoglycate was achieved on Hypersil BDS C18 (100 mm x 2.1 mm, 1.7 μm) with gradient mobile phase containing methanol, orthophosphoric acid and acetonitrile in the ratio of 50:15:35 %v/v/v. The flow rate was 0.25 mLmin-1, injection volume 20μl and detection wavelength was set at 326nm, at ambient temperature. The validation of the proposed method was carried outfor linearity, accuracy, precision, robustness, limit of detection and

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11

Zhang, Yan Feng, and Ting Ting Li. "A Kind of Classification Algorithms of Data Mining and Quantitative Analysis." Advanced Materials Research 655-657 (January 2013): 963–68. http://dx.doi.org/10.4028/www.scientific.net/amr.655-657.963.

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C4.5, Bayesian network and Sequential Minimal Optimization (SMO) are three typical classification algorithms in data mining. Using cross-validation method with 10 folds get analysis and calculation results of the experiments for the three classification algorithms in the same training set and test set. The main metrics include accuracy, precision, speed, robustness, scalability and comprehensibility, we use margin curve show these. It provides a theoretical and experimental basis for users to select a proper classification algorithm with different training sets in quality and amount.

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Moldovan, Constantin Catalin, and Ionel Staretu. "Analysis of the Accuracy and Robustness of Kinect Sensor Used with the Scope of Robot Manipulation." Applied Mechanics and Materials 555 (June 2014): 170–77. http://dx.doi.org/10.4028/www.scientific.net/amm.555.170.

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This paper describes in details the evaluation procedure developed in this paper for the measurement of the Kinect sensors accuracy and robustness in the detection process of the user hand and recognizing human hand gestures. Furthermore, the results are transferred to a robotic gripper in virtual environment for visualization. The research started with consideration on the current state of the methods and sensors used for the detection of the hand gestures. It was seen that the detection of human hand and gestures recognition represent an important research study in the field of robotics cont

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Bharani Pandilla, Chitra K, Nalini C N, Ashok P, and Vadivelan R. "Method development and validation of Ifetroban by RP-UPLC." International Journal of Research in Pharmaceutical Sciences 11, no. 3 (2020): 3158–63. http://dx.doi.org/10.26452/ijrps.v11i3.2429.

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The purpose of this work is to develop and validate reverse phase Ultra performance liquid chromatography (UPLC) method for the rapid and precise determination of ifetroban sodium in its pure form and in formulations. A simple, specific, accurate, precise isocratic UPLC method for analysis of Ifetroban sodium was developed and validated using a Phenomenex C18 column (50 mm x 3.0 mm, 3µ) as the stationary phase, in conjunction using Triethyl amine buffer: methanol in the proportion of 25:75 with a flow rate of 1.0 mL/min, run time is 3 min and UV detector is used at 235 nm wavelength. The devel

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Donaldson, Douglas, Shobha Purushothama, Eric David, et al. "Well-developed ligand-binding assays demonstrate robust performance using singlet analysis." Bioanalysis 11, no. 22 (2019): 2075–86. http://dx.doi.org/10.4155/bio-2019-0189.

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Aim: Replicate sample testing has long been regarded as a necessity for bioanalytical laboratory testing, especially in the realm of ligand-binding assays (LBAs). In an era in which results were derived from crude test tube-based assays, the replication of results was warranted. Those assays were often imprecise and required multiple replicates to arrive at results that approached accuracy. However, given technological advancements and excellent accuracy and precision of many modern LBAs, the practice of replicate testing should be re-evaluated. Although most regulatory guidelines allow for si

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15

Onjia, Antonije, Tatjana Vasiljevic, Djuro Cokesa, and Mila Lausevic. "Validation of chromatographic analysis." Chemical Industry 56, no. 2 (2002): 76–79. http://dx.doi.org/10.2298/hemind0202076o.

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The parameters for the development of a chromatographic (HPLC) method and its validation are discused in the paper. Chromatographic analysis involves a multi-step procedure consisting of sample collection, pretreatment instrumental measurements and data processing. Emphasize was placed on the instrumental part of the analysis presuming that the contributions of the other variables were minor. The roles of precision, accuracy, detection limit, quantification limit, specificity, selectivity, range, linearity and robustness, as well as system suitability in the analytical application of chromatog

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16

Uçaktürk, Ebru. "Development of Sensitive and Specific Analysis of Vildagliptin in Pharmaceutical Formulation by Gas Chromatography-Mass Spectrometry." Journal of Analytical Methods in Chemistry 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/707414.

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A sensitive and selective gas chromatography-mass spectrometry (GC-MS) method was developed and fully validated for the determination of vildagliptin (VIL) in pharmaceutical formulation. Prior to GC-MS analysis, VIL was efficiently derivatized with MSTFA/NH4I/β-mercaptoethanol at 60°C for 30 min. The obtained O-TMS derivative of VIL was detected by selected ion monitoring mode using the diagnostic ionsm/z223 and 252. Nandrolone was chosen as internal standard. The GC-MS method was fully validated by the following validation parameters: limit of detection (LOD) and quantitation (LOQ), linearity

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Oliveira, Agna Heliade, Valmir Gomesde Souza, FÁbio Santosde Souza, and Rui Oliveira Macedo. "DEVELOPMENT AND VALIDATION OF HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY WITH DIODE ARRAY DETECTOR METHOD TO ANALYSIS OF KAEMPFEROL MARKER FROM EXTRACTS OF POINCIANELLA PYRAMIDALIS (TUL) L.P QUEIROZ." Asian Journal of Pharmaceutical and Clinical Research 10, no. 12 (2017): 252. http://dx.doi.org/10.22159/ajpcr.2017.v10i12.21321.

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Objective: This study aims to develop the extraction of the marker kaempferol in the fluid extract (FE) and validate an analytical method that monitors the quality of extracts of P. pyramidalis. Methods: The P. pyramidalis leaves were collected and then were dried to milling process. The extracts were drawn up at 20% weight: Volume (w/v) by maceration, and the extraction system used was hydroethanol solution ratio at 50:50 volume: Volume (v: v). From the hydroalcoholic extract, a method of extracting the kaempferol biomarker was developed and validated by high-performance liquid chromatography

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18

Jagnade, Sneha, Pushpendra Soni, and Lavakesh Kumar Omray. "Development and Validation of a Green Analytical Method for the Determination of Aspirin and Domperidone Bulk or Formulation Using UV and HPLC." Journal of Drug Delivery and Therapeutics 10, no. 6 (2020): 49–56. http://dx.doi.org/10.22270/jddt.v10i6.4374.

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The aim of present study was to investigate the development and validation of a green analytical method for the determination of aspirin and domperidone. Method Development and Validation for Estimation of Domperidone and Aspirin in bulk or formulation by using RP-HPLC. The RP-HPLC method was developed for estimation of Aspirin and Domperidone in synthetic mixture by isocratically using 10 mM KH2PO4: Acetonitrile (20:80) as mobile phase, Prontosil C-18 column (4.6 x 250 mm, 5μparticle size) column as stationary phase and chromatogram was recorded at 231 nm. Then developed method was validated

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E Souza, marinês J., Natália Canedo, Paulo S. Souza Filho, and Ana M. Bergold. "Development of an Ultraviolet Spectrophotometric Method for the Determination of Ceftiofur Sodium Powder." Journal of AOAC INTERNATIONAL 92, no. 6 (2009): 1673–80. http://dx.doi.org/10.1093/jaoac/92.6.1673.

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Abstract A UV spectrophotometric method was developed for determination of ceftiofur sodium in the drug substance and sterile powder for injection. The method validation, which yielded good results, included evaluation of the range, linearity, intraand interday precision, accuracy, recovery, specificity, robustness, LOQ, and LOD. The UV spectrophotometric determinations were performed at 292 nm. Good linearity was obtained between 2.5 and 20.0 g/mL. A prospective validation showed that the method is linear (r = 0.9999) and precise, with RSD values of 0.3 for product A and 0.4 for product B. Th

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Fiorante, Pedro de Freitas, Rodrigo Dias Martins, and Mauri Sergio Alves Palma. "Development and validation of analytical methodology with focus on the qualification of powder mixers." Brazilian Journal of Pharmaceutical Sciences 51, no. 2 (2015): 273–84. http://dx.doi.org/10.1590/s1984-82502015000200004.

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<p>This study aims at developing an analytical procedure capable of quantifying the ferric oxide present in the mixture of ferric oxide/lactose monohydrate (0.4% w/w). The analytical procedure was checked for specificity, linearity, precision (system repeatability, procedure repeatability and intermediate precision), accuracy, stability of solutions and robustness of the procedure. The concentration of Fe (III) was determined by spectrophotometry at 480 nm based on calibration curves. The specificity was verified. The linearity was obtained in the range of 11.2 to 16.8 µg of ferric oxide

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Gupta, N. K., A. Peepliwal, D. S. Rathore, and P. Gupta. "Simultaneous Spectrophotometric Estimation of Telmisartan and Amlodipine Besylate in Tablet Dosage Form." Indian Journal of Pharmaceutical and Biological Research 3, no. 03 (2015): 50–54. http://dx.doi.org/10.30750/ijpbr.3.3.8.

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A simple, accurate and reproducible spectrophotometric methods have been developed for the simultaneous estimation of Telmisartan (TEL) and Amlodipine Besylate (AML) in combined tablet dosage forms. The method involves determination using the simultaneous equation method, the sampling wavelengths selected are ‘TLM’ = 297nm.and ‘AML’ =238nm., over the concentration ranges of 8-48μg/ml for ‘TEL’ and 1-6 μg/ml for ‘AML’ respectively. The method was validated for linearity, accuracy, precision, robustness and application for assay as per ICH guidelines. The proposed method is simple, economical, a

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22

Qadeer, Abdul, and Yaseen Jan. "ANALYSIS OF DETERMINING CONCENTRATION OF 3QUINUCLIDINOL IN DRUG SUBSTANCES." Chemistry & Material Sciences Research Journal 2, no. 2 (2020): 60–65. http://dx.doi.org/10.51594/cmsrj.v2i2.139.

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The goal of the study was to determine low level concentrations of 3-quinuclidinol in solifenacin succinate drug substance by using gas chromatography system. 3-quinuclidinol was used as an intermediate in the process of synthesis of solifenacin succinate. The method development was initiated with solifenacin succinate, solubility of 3-quinuclidinol, extraction and miscibility studies, chosen with 6 N sodium hydroxide solution and chloroform solvents. The method of the study was validated based on the guidelines provided by ICH. The criteria were method precision, robustness, accuracy, lineari

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Raju, V. Bhaskara, and A. Lakshmana Rao. "Development, Estimation and Validation of Lisinopril in Bulk and its Pharmaceutical Formulation by HPLC Method." E-Journal of Chemistry 9, no. 1 (2012): 340–44. http://dx.doi.org/10.1155/2012/292754.

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An accurate and preciseHPLCmethod was developed for the determination of lisinopril. Separation of the drug was achieved on a reverse phase C8column using a mobile phase consisting of phosphate buffer and methanol in the ratio of 35:65v/v. The flow rate was 0.8 mL/min and the detection wavelength was 215 nm. The linearity was observed in the range of 20-60 μ g/mL with a correlation coefficient of 0.9992. The proposed method was validated for its linearity, accuracy, precision and robustness. This method can be employed for routine quality control analysis of lisinopril in tablet dosage forms.

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S. Khadeerunnisa, T. VimalakKannan, and T. Vijaya Lakshmi. "Spectrophotometric determination and estimation of minoxidil in tablet dosage form by UV." International Journal of Research In Pharmaceutical Chemistry and Analysis 1, no. 2 (2019): 47–51. http://dx.doi.org/10.33974/ijrpca.v1i2.73.

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A simple, precise, accurate and economical UV spectrophotometric method has been developed and validated for the estimation of Minoxidil in the tablet dosage form. Minoxidil shows maximum absorbance at 279.4nm. The method was carried out by using 0.1N HCl as a solvent. The drug shows linearity from the concentration range of 1-6µg/ml and correlation coefficient was found to be 0.9992. The proposed method was statistically validated for precision, accuracy, ruggedness, robustness, the limit of detection, quantitation as per the ICH guidelines. Hence this method can be successfully applied for r

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Osmanović Omerdić, Ehlimana, Larisa Alagić-Džambić, Marko Krstić, Maja Pašić-Kulenović, Jadranka Odović, and Dragana Vasiljević. "In Vitro Dissolution Study of Acetylsalicylic Acid and Clopidogrel Bisulfate Solid Dispersions: Validation of the RP-HPLC Method for Simultaneous Analysis." Applied Sciences 10, no. 14 (2020): 4792. http://dx.doi.org/10.3390/app10144792.

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Solid dispersions were prepared via a solvent evaporation method, employing ethanol (96%, v/v) as solvent, with three different polymers as carrier: povidone, copovidone, and poloxamer 407. Previously developed reversed-phase HPLC (RP-HPLC) methods were modified and used for the simultaneous determination of acetylsalicylic acid and clopidogrel bisulfate and after release from solid dispersions. Chromatography was carried out on a C-18 column, with a mobile phase of acetonitrile–methanol–phosphate buffer pH 3.0, UV detection at 240 nm, and a run time of 6 min. The method was validated accordin

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Gan, Shu Chuan, Ai Hua Zhou, Hui Guo, and Ling Tang. "Application of Variable Precision Rough Set in Power Transformer Fault Diagnosis." Applied Mechanics and Materials 373-375 (August 2013): 824–28. http://dx.doi.org/10.4028/www.scientific.net/amm.373-375.824.

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The variable precision rough set theory is introduced into the fault diagnosis of power transformer. Using the reduction method of the variable precision rough set,the hidden information in power transformer faults data is reduced , and the information which plays a major role in fault classification can be obtained. This approach can overcome the defects of the classical rough set, such as the sensitivity to noise of input information, and accordingly improves the accuracy of fault diagnosis. The example shows that the variable precision rough set used in the power transformer fault diagnosis

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Usmani, Muneeba, Sofia Ahmed, Muhammad Ali Sheraz, and Iqbal Ahmad. "Development and Validation of a Pre-Column Derivatization HPLC Method for the Assay of Amikacin Sulfate in Pure and Parenteral Dos age Forms." Current Pharmaceutical Analysis 15, no. 5 (2019): 511–20. http://dx.doi.org/10.2174/1573412914666180314121213.

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Background: Amikacin sulfate (AMK) belongs to the class of aminoglycoside antibiotics. It is effective against the infections caused by Gram-negative and positive bacteria. AMK lacks a chromophore group in its structure and, therefore, it does not absorb light in the 200-800 nm region which makes it a difficult molecule to analyze by UV detector using high performance liquid chromatography (HPLC). Objective: This study has been carried out to develop and validate a relatively simple, accurate, precise, rapid, economical, and stability-indicating pre-column derivatization HPLC method for the de

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Horvath, Peter, Thomas Wild, Ulrike Kutay, and Gabor Csucs. "Machine Learning Improves the Precision and Robustness of High-Content Screens." Journal of Biomolecular Screening 16, no. 9 (2011): 1059–67. http://dx.doi.org/10.1177/1087057111414878.

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Imaging-based high-content screens often rely on single cell-based evaluation of phenotypes in large data sets of microscopic images. Traditionally, these screens are analyzed by extracting a few image-related parameters and use their ratios (linear single or multiparametric separation) to classify the cells into various phenotypic classes. In this study, the authors show how machine learning–based classification of individual cells outperforms those classical ratio-based techniques. Using fluorescent intensity and morphological and texture features, they evaluated how the performance of data

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Tangyuenyongwatana, Prasan, Vichien Keeratinijakal, and Wandee Gritsanapan. "Thin-Layer Chromatography-Densitometry Analysis of Dimethoxyphenylbutadiene Content in Zingiber cassumunar Rhizomes." Journal of AOAC INTERNATIONAL 95, no. 6 (2012): 1614–17. http://dx.doi.org/10.5740/jaoacint.11-188.

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Abstract Zingiber cassumunar (Zingiberaceae) has been widely used as a traditional medicine in southeast Asia, especially Thailand, for treatment of asthma, inflammation, and joint pain. (E)-4-(3,4-dimethoxyphenyl)butadiene, or DMPBD, a major component in the rhizome, has been reported to be an active anti-inflammatory agent. This research developed a TLC-densitometry method for the simultaneous quantification of DMPBD in the rhizome extracts of four varieties of Z. cassumunar. DMPBD was found in the range of 1.80 ± 0.01 to 3.23 ± 0.10% (w/w). The method was validated for linearity, precision,

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Wang, He Nian, Guo Xing Yi, Chang Hong Wang, and Yang Guang Xie. "Adaptive H₂/H_∞ Hybrid Filter Based on Convex Optimization." Advanced Materials Research 739 (August 2013): 586–91. http://dx.doi.org/10.4028/www.scientific.net/amr.739.586.

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The INS/GPS integrated navigation as the research object, based on in-depth analysis of the multiple model filter method, the convex optimization hybrid filtering method based on adaptive optimization. OLS-SVM method utilizes real-time to obtain the weighted value of the hybrid filter, enables the weight value can be varied with the real-time filtering effect of changes. Therefore, it can effectively improve the system robustness, thus affecting the estimation precision of the whole system. The simulation results show that, the method of state model instability and filter unreliable has strong

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Lo, Wing-Cheong, Shaohua Zhou, Frederic Y. M. Wan, Arthur D. Lander, and Qing Nie. "Robust and precise morphogen-mediated patterning: trade-offs, constraints and mechanisms." Journal of The Royal Society Interface 12, no. 102 (2015): 20141041. http://dx.doi.org/10.1098/rsif.2014.1041.

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The patterning of many developing tissues is organized by morphogens. Genetic and environmental perturbations of gene expression, protein synthesis and ligand binding are among the sources of unreliability that limit the accuracy and precision of morphogen-mediated patterning. While it has been found that the robustness of morphogen gradients to the perturbation of morphogen synthesis can be enhanced by particular mechanisms, how such mechanisms affect robustness to other perturbations, such as to receptor synthesis for the same morphogen, has been little explored. Here, we investigate the int

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Garcia, Cássia V., Clésio S. Paim, and Martin Steppe. "New Liquid Chromatographic Method for Determination of Rabeprazole Sodium in Coated Tablets." Journal of AOAC INTERNATIONAL 87, no. 4 (2004): 842–46. http://dx.doi.org/10.1093/jaoac/87.4.842.

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Abstract Rabeprazole sodium is a proton pump inhibitor that covalently binds and inactivates the gastric parietal cell proton pump (H+/K+ ATPase). Little has been published about the quantitative determination of this drug. The aim of this research was to develop a new liquid chromatographic method for quantitative determination of rabeprazole in coated tablets. The system consisted of a Hypersil Keystone Betabasic C8 column (250 × 4.6 mm, 5 μm particle size), an isocratic acetonitrile–water (35 + 65) mobile phase at a flow rate of 1.0 mL/min, and a diode array detector set at 282 nm. The foll

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Wang, Xuezhen, Feixue Chen, RenFeng Zhu, et al. "A Review on Disturbance Analysis and Suppression for Permanent Magnet Linear Synchronous Motor." Actuators 10, no. 4 (2021): 77. http://dx.doi.org/10.3390/act10040077.

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In high-end testing and manufacturing equipment, a trend exists whereby the traditional servo feed system with a ball screw and rotary motor will gradually be replaced by a direct drive system. The precision motion system driven by a permanent magnet linear synchronous motor (PMLSM) offers several advantages, including high speed, high acceleration, and high positioning accuracy. However, the operating precision of the feed device will be affected by the PMLSM robustness to nonlinear and uncertain disturbances, such as cogging force, friction, thermal effects, residual vibration, and load dist

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Nallathambi, Gayathri, V. Sekar, and Surendra kumar.M. "Method Development and Validation of Quantitative Estimation of Vilazodone Hydrochloride by UV and RP-HPLC." International Journal of PharmTech Research 13, no. 4 (2020): 362–73. http://dx.doi.org/10.20902/ijptr.2019.130408.

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The aim of the study is to develop some new analytical method development and Validation of Quantitative Estimation of Anti-depressant Drug Vilazodone by UV and HPLC was found to be simple, specific, precise, accurate, rapid and economical. The method was developed and validated as per ICH guidelines, concerning accuracy, precision, linearity, ruggedness, limit of detection, limit of quantification and robustness and forced degradation studies. The GRACE ODS phenyl column (4.6 x 150mm,5μm) column was maintained at an ambient temperature and 232 nm λ max conditions. The mixture of di-potassium

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Housheh, Samer, Daoud Ali, Saleh Trefi, Haroun Mohammad, and M. Fawaz Chehna. "Optimization of RP-HPLC Assay for Pharmaceutical Analysis of Clopidogrel." International Journal of Pharmaceutical Sciences and Nanotechnology 7, no. 1 (2014): 2371–76. http://dx.doi.org/10.37285/ijpsn.2014.7.1.9.

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An accurate, sensitive, precise and stability-indicating reversed phase high performance liquid chromatographic (RP-HPLC) method for the analysis of clopidogrel bisulfate was developed and validated. The chromatographic conditions comprised of a reversible phase C18 column (250 × 4.6 mm, 5 μm) with a mobile phase consisting of a mixture of 50 mM potassium di-hydrogen phosphate and acetonitrile in the ratio of 75:25 at pH 3.0 adjusted with phosphoric acid. The flow rate was 1ml/min, the detection was carried out at 247 nm and the retention time of clopidogrel was 6.5 min. Clopidogrel was subjec

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Deng, Jiang Hai, Wen Jun Yan, and Qiang Yang. "A Micro-Resistance Measurement Based Design Approach of Digital Micro-Ohmmeter." Advanced Materials Research 339 (September 2011): 36–42. http://dx.doi.org/10.4028/www.scientific.net/amr.339.36.

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This paper presents a novel design solution of digital micro-ohmmeter based on the micro-resistance measurements. Through the system analysis, two key factors which have impacts on the measurement accuracy are identified: constant-current source circuit and A/D converter. Therefore, we suggest a design approach to improve the common constant-current source circuit to obtain enhanced system linearity, stability, precision and robustness and use high resolution A/D converter to ensure converting accurately. The proposed design approach is assessed and demonstrates that the load disturbance can b

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Rubert Nogueira-Librelotto, Daniele, Laís Engroff Scheeren, Clarice Madalena Bueno Rolim, Letícia Bueno Macedo, and Joana Rodrigues Fernandes. "DETERMINATION OF DOXORUBICIN HYDROCHLORIDE IN PHARMACEUTICA DOSAGE FORMS BY A SIMPLE STABILITY-INDICATING MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY METHOD." Drug Analytical Research 3, no. 1 (2019): 29–35. http://dx.doi.org/10.22456/2527-2616.91896.

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A stability-indicating micellar electrokinetic capillary chromatography (MEKC) method was developed and validated for the analysis of doxorubicin hydrochloride in injectable pharmaceutical dosage forms, using methotrexate as internal standard. A fused-silica capillary (50 µm i.d.; effective length, 40 cm) and a running electrolyte solution consisting of 10 mM borate buffer and 20 mM anionic surfactant SDS, at pH 9.3, were set as the best experimental conditions. Moreover, the capillary temperature was maintained at 26 ºC, while the applied voltage was +26 kV. Hydrodynamic sample injection (6 s

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Kang, Cheng Ming, Chun Yu Zhao, and Jun Qian Zhang. "Thermal behavior analysis and experimental study on the vertical machining center spindle." Transactions of the Canadian Society for Mechanical Engineering 44, no. 3 (2020): 344–51. http://dx.doi.org/10.1139/tcsme-2019-0124.

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Thermal errors caused by spindle rotation is a major factor that influences the precision stability of CNC machine tools. To determine an effective method for reducing thermal errors, a thermal experiment was carried out on the spindle of a vertical drilling center. The thermal deformation mechanism and thermal error variations of the spindle are presented. Based on the generation, convection, and conduction theory of heat, the thermal field model of a spindle system is derived. The relationship between the thermal field and the radial thermal error is established using a physically based meth

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Li, Yu, Jinggang Chu, Guozhen Wei, Sifan Jin, Tiantian Yang, and Bo Li. "Robust Placement of Water Quality Sensor for Long-Distance Water Transfer Projects Based on Multi-Objective Optimization and Uncertainty Analysis." Sustainability 13, no. 4 (2021): 1834. http://dx.doi.org/10.3390/su13041834.

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It is important to place water quality sensors along open channels in long-distance water transfer projects optimally for rapid source identification and efficient management of sudden water contamination. A new framework which considers multiple objectives, including earliest detection time, lowest missing detection rate and lowest sensor cost, and combines the randomness of injected contaminant type and contaminant incident consisting of contaminant intrusion location, time and mass, was established to obtain optimal placement of water quality sensor with better robustness in this paper. The

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Afshar, Minoo, Niloufar Salkhordeh, and Mehdi Rajabi. "An Ecofriendly and Stability-Indicating HPLC Method for Determination of Permethrin Isomers: Application to Pharmaceutical Analysis." Journal of Chemistry 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/697831.

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A green, simple, and stability-indicating RP-HPLC method was developed for simultaneous determination of permethrin isomers in pharmaceutical preparations. The separation was based on a C18analytical column (150 × 4.6 mm, i.d., 5 μm). The mobile phase consisted of ethanol: phosphoric acid solution (pH = 3) (67 : 33, v/v). The elution was carried out at 30°C temperature with a flow rate of 1.0 mL/min. Quantitation was achieved with UV detection at 215 nm. In forced degradation studies, the drug was subjected to oxidation, hydrolysis, photolysis, and heat. The method was validated for specificit

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Weiss, Caryn L., Mark R. Fairchild, Brian Stanton, Bertil S. Nshime, and Paul D. Parkanzky. "Innovative Method for the Analysis of Dexpanthenol in Hair Care Products." Journal of AOAC INTERNATIONAL 102, no. 2 (2019): 633–37. http://dx.doi.org/10.5740/jaoacint.18-0053.

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Abstract Background: Dexpanthenol is a widely used humectant in hair care products, especially anti-hairfall products. The hair care industry is highly regulated in East Asia and treats products containing the combination of dexpanthenol, zinc pyrithione, and nicotinamide (vitamin B3) as quasi-drugs. Objective: Because dexpanthenol lacks a UV chromophore, existing methodologies for analysis in finished products include pretreatments and/or HPLC-UV analysis at low wavelengths at which poor signal-to-noise is observed.These time-consuming methods lack the robustness needed for routine use in qua

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Patro, S. K., S. K. Kanungo, V. J. Patro, and N. S. K. Choudhury. "Stability Indicating RP-HPLC Method for Determination of Valsartan in Pure and Pharmaceutical Formulation." E-Journal of Chemistry 7, no. 1 (2010): 246–52. http://dx.doi.org/10.1155/2010/487197.

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A simple, rapid and accurate and stability indicating RP-HPLC method was developed for the determination of valsartan in pure and tablet forms. The method showed a linear response for concentrations in the range of 50-175 µg/mL using 0.01 M NH4H2PO4(pH 3.5) buffer: methanol [50:50] as the mobile phase with detection at 210 nm and a flow rate of 1 mL/min and retention time 11.041 min. The method was statistically validated for accuracy, precision, linearity, ruggedness, robustness, forced degradation, solution stability and selectivity. Quantitative and recovery studies of the dosage form were

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Rubim, Alexandre Machado, Jaqueline Bandeira Rubenick, Luciane Varine Laporta, and Clarice Madalena Bueno Rolim. "A simple method for the quantification of diclofenac potassium in oral suspension by high-performance liquid chromatography with UV-detection." Brazilian Journal of Pharmaceutical Sciences 49, no. 3 (2013): 589–97. http://dx.doi.org/10.1590/s1984-82502013000300021.

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A rapid, simple and low cost method was developed to determine diclofenac potassium (DP) in oral suspension, using a reverse-phase column (C8, 150 mm x 4.6 mm, 5 µm), mobile phase containing methanol/buffer phosphate (70:30 v/v, pH 2.5), at a flow rate of 1.0 mL/min, isocratic method, and ultraviolet detection at 275 nm. A linear response (r = 1.0000) was observed in the range of 10.0-50.0 µg/mL. Validation parameters such as linearity, specificity, precision, accuracy and robustness were evaluated. The method presented precision (repeatability: relative standard deviation = 1.21% and intermed

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Sahu, Prafulla Kumar, M. Mathrusri Annapurna, and Dillipkumar Sahoo. "A Simple and Sensitive HPLC Method for Simultaneous Analysis of Nabumetone and Paracetamol in Pharmaceutical Formulations." E-Journal of Chemistry 8, s1 (2011): S41—S46. http://dx.doi.org/10.1155/2011/607069.

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This paper describes a high-performance liquid chromatographic method for simultaneous estimation of nabumetone and paracetamol in binary mixture. The method was based on RP-HPLC separation and quantitation of the two drugs on hypersil C-18 column (250 mm × 4.6 mm) using a mobile phase consisting of acetonitrile and 0.05% aqueous acetic acid (70:30v/v) at flow rate of 1 mL min-1. Quantitation was achieved with PDA detector at 238 nm based on peak area with linear calibration curves at concentration ranges 5-25 µg mL-1for both the drugs. Naproxen sodium was used as internal standard. The method

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Todeschini, Vitor, Regiane Leite, Maximiliano Sangoi, Paulo Oliveira, and Thiago Barth. "MULTICOMPONENT SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ANALYSIS OF DELAPRIL AND INDAPAMIDE IN TABLETS." Drug Analytical Research 1, no. 1 (2017): 50–55. http://dx.doi.org/10.22456/2527-2616.74119.

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A multicomponent ultraviolet (UV) spectrophotometric method was developed and validated for simultaneous determination of delapril (DEL) and indapamide (IND) in tablets employing the partial least squares regression (PLSR) approach. The PLSR method was developed by a multilevel factorial design using 25 synthetic mixtures of drugs and a significant predict model (p < 0.05) were obtained at 225 nm for DEL (r2 = 0.9992) and 243 nm for IND (r2 = 0.9997). Validation parameters such as the specificity, linearity, precision, accuracy and robustness were evaluated in accordance with the ICH requir

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Bharani Pandilla, Chitra K, Nalini C N, and Ashok P. "Method development and validation of droxidopa by HPLC technique." International Journal of Research in Pharmaceutical Sciences 11, no. 4 (2020): 6227–32. http://dx.doi.org/10.26452/ijrps.v11i4.3302.

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The purpose of this work is to develop and validate stability, indicating reverse phase High-performance liquid chromatography (HPLC) method for the rapid and precise determination of droxidopa in its pure form and formulations. A simple, fast, accurate and economical way has been developed and validated for the quantification of droxidopa by HPLC technique. The chromato graphic system was equipped with Shimpack columnC18((250x 4.6) mm, 5µ) as stationary phase and UV detector at 220 nm, in conjunction with a mobile phase of phosphate buffer pH 2.0:acetonitrile (60:40,% v/v) at a flow rate of 1

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Canavan, Seal J., and Carl W. Ramm. "Accuracy and Precision of 10 Year Predictions for Forest Vegetation Simulator—Lake States." Northern Journal of Applied Forestry 17, no. 2 (2000): 62–70. http://dx.doi.org/10.1093/njaf/17.2.62.

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Abstract This study is a followup to the 5 yr validation of the Lake States TWIGS (The Woodsman's Ideal Growth Projection System) projection system by Guertin and Ramm (1996). Accuracy and precision of 10 yr diameter growth, basal area growth and mortality predicted by the Lake States variant of the Forest Vegetation Simulator (FVS) were evaluated for seven upland hardwood species in Michigan's northern Lower Peninsula. The robustness of FVS predictions was examined by varying projection cycle length and the level of detail of stand and tree-information included in growth projections.The data

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Mishra, Kaushelendra, Himesh Soni, Govind Nayak, Sita Sharan Patel, and A. K. Singhai. "Method Development and Validation of Metformin Hydrochloride in Tablet Dosage Form." E-Journal of Chemistry 8, no. 3 (2011): 1309–13. http://dx.doi.org/10.1155/2011/768014.

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A simple, reproducible and efficient method for the determination of metformin hydrochloride (MET) was developed and validated. The analysis complied with Beer's law in the concentration range of 8-13 μg/mL at 233 nm for MET. In our study the validation of analytical method for determination of MET by UV in tablets formulation was performed in accordance the parameters including-system suitability, specificity, limit of quantification, limit of detection, linearity of response, accuracy, precision (reproducibility & repeatability), robustness (change of wave length±2 nm).

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Jain, P. S., P. R. Badreshiya, S. S. Chalikwar, A. A. Todarwal, and S. J. Surana. "Validation of a dissolution method with RP-HPLC analysis for Perindopril erbumine and Indapamide combination tablet." Chemical Industry and Chemical Engineering Quarterly 18, no. 1 (2012): 19–25. http://dx.doi.org/10.2298/ciceq110628042j.

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A Dissolution method with high performance liquid chromatography (HPLC) analysis was validated for perindopril erbumine and indapamide in combination tablet formulation. The method was validated to meet requirements for a global regulatory filing and this validation included specificity, linearity, accuracy, precision, range, robustness and solution stability studies. The dissolution method, which uses USP apparatus 1 with basket rotating at 100 rpm, 1000 ml of phosphate buffer pH 6.8 as the dissolution medium, and reversed-phased HPLC was carried out at 50?C on a 4.6mm?250mm 5?m cyano column

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Yilmaztekin, Murat, and Turgut Cabaroglu. "Confirmatory Method for the Determination of Volatile Congeners and Methanol in Turkish Raki According to European Union Regulation (EEC) No. 2000R2870: Single-Laboratory Validation." Journal of AOAC INTERNATIONAL 94, no. 2 (2011): 611–17. http://dx.doi.org/10.1093/jaoac/94.2.611.

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Abstract A method described by European Union Regulation (EEC) No. 2000R2870 was validated and supported by GC/MS analysis for the determination of volatile congeners and methanol in Turkish raki. The method was validated in terms of specificity, accuracy, precision, LOD, LOQ, linearity, and robustness. The specificity of the method was demonstrated, and the method showed excellent accuracy (97.5100.1). Linearity was checked in the ranges of 0.20026.390 mg/100 mL for more volatile compounds and 1.15548.00 mg/100 mL for less volatile compounds, after concentrations found in Turkish raki were ta

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