Academic literature on the topic 'Acetaldehyde Scavengers'

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Journal articles on the topic "Acetaldehyde Scavengers"

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Mrozinski, Brent A., Yong-Wah Kim, Elizabeth A. Lofgren, and Saleh A. Jabarin. "Chemistry of the interactions of acetaldehyde scavengers for poly(ethylene terephthalate)." Journal of Applied Polymer Science 130, no. 6 (2013): 4191–200. http://dx.doi.org/10.1002/app.39702.

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Mrozinski, Brent A., Elizabeth A. Lofgren, and Saleh A. Jabarin. "Acetaldehyde scavengers and their effects on thermal stability and physical properties of poly(ethylene terephthalate)." Journal of Applied Polymer Science 125, no. 3 (2012): 2010–21. http://dx.doi.org/10.1002/app.36287.

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Neill, M. A., and S. J. Klebanoff. "The effect of phenolic glycolipid-1 from Mycobacterium leprae on the antimicrobial activity of human macrophages." Journal of Experimental Medicine 167, no. 1 (1988): 30–42. http://dx.doi.org/10.1084/jem.167.1.30.

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Purified PGL-1 and dPGL from M. leprae can prevent bacterial killing by intact phagocytes and cell-free antimicrobial systems. Both glycolipids completely abolished the antimicrobial effect of the acetaldehyde-XO-Fe2+ system. Because the cytotoxicity of this system is inhibited by catalase, SOD, mannitol, and ethanol, but not by heated SOD or catalase, these data suggest that toxicity is due to OH. generated by the Haber-Weiss reaction. That the antimicrobial killing in the XO system is completely blocked by the addition of PGL-1 or dPGL suggests that these glycolipids can act as OH. scavengers. A modest protective effect against the cytotoxicity of the MPO-H2O2-halide system by both PGL-1 and dPGL was also observed. The antimicrobial activity of the MPO system was abolished with chloride, but not iodide, as the halide. The effect of the M. leprae-derived glycolipid on bacterial killing by intact phagocytes was examined. Two linking antibodies were used to bind the dPGL to a rapidly growing test organism, S. aureus, a murine IgM mAb specific for the terminal glycoside of PGL-1, and a rabbit IgG anti-mouse IgM which bound the staphylococcal protein A via its Fc region. Examination by transmission EM of human monocyte-derived macrophages which had ingested staphylococci either coated with both antibodies and dPGL, or coated only with the IgG and IgM antibodies, demonstrated the presence of bacteria in phagosomes of control and IFN-gamma-activated macrophages. Activation of the macrophage monolayers by pretreatment with IFN-gamma markedly increased their staphylocidal activity. When dPGL coated staphylococci were ingested, killing by both control and IFN-gamma-activated macrophages was completely blocked. These results, suggesting that PGL-1 can scavenge reactive oxygen species and prevent microbial death within the phagosome, may in part explain the intracellular survival of M. leprae in certain cell types.
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Clemens, Dahn, Michael Duryee, Cleofes Sarmiento, et al. "Novel Antioxidant Properties of Doxycycline." International Journal of Molecular Sciences 19, no. 12 (2018): 4078. http://dx.doi.org/10.3390/ijms19124078.

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Doxycycline (DOX), a derivative of tetracycline, is a broad-spectrum antibiotic that exhibits a number of therapeutic activities in addition to its antibacterial properties. For example, DOX has been used in the management of a number of diseases characterized by chronic inflammation. One potential mechanism by which DOX inhibits the progression of these diseases is by reducing oxidative stress, thereby inhibiting subsequent lipid peroxidation and inflammatory responses. Herein, we tested the hypothesis that DOX directly scavenges reactive oxygen species (ROS) and inhibits the formation of redox-mediated malondialdehyde-acetaldehyde (MAA) protein adducts. Using a cell-free system, we demonstrated that DOX scavenged reactive oxygen species (ROS) produced during the formation of MAA-adducts and inhibits the formation of MAA-protein adducts. To determine whether DOX scavenges specific ROS, we examined the ability of DOX to directly scavenge superoxide and hydrogen peroxide. Using electron paramagnetic resonance (EPR) spectroscopy, we found that DOX directly scavenged superoxide, but not hydrogen peroxide. Additionally, we found that DOX inhibits MAA-induced activation of Nrf2, a redox-sensitive transcription factor. Together, these findings demonstrate the under-recognized direct antioxidant property of DOX that may help to explain its therapeutic potential in the treatment of conditions characterized by chronic inflammation and increased oxidative stress.
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Moretto, Nadia, Fabrizio Facchinetti, Thomas Southworth, Maurizio Civelli, Dave Singh та Riccardo Patacchini. "α,β-Unsaturated aldehydes contained in cigarette smoke elicit IL-8 release in pulmonary cells through mitogen-activated protein kinases". American Journal of Physiology-Lung Cellular and Molecular Physiology 296, № 5 (2009): L839—L848. http://dx.doi.org/10.1152/ajplung.90570.2008.

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Cigarette smoking is the major risk factor for chronic obstructive pulmonary disease (COPD), a syndrome characterized by pulmonary neutrophil infiltration, chronic inflammation, and progressive tissue destruction. We examined here the acute effect of aqueous cigarette smoke extract (CSE) and of two α,β-unsaturated aldehydes (acrolein and crotonaldehyde) contained in CSE in cultured normal human lung fibroblasts and small airway epithelial cells. By examining a panel of 19 cytokines and chemokines, we found that IL-8 release was elevated by CSE as well as by acrolein, whereas other inflammatory mediators were mostly unaffected. CSE-evoked IL-8 release was mimicked by acrolein and crotonaldehyde at concentrations (3–60 μM each) found in CSE and fully prevented by 1 mM α,β-unsaturated aldehydes scavengers N-acetylcysteine (NAC) or sodium 2-mercaptoethanesulfonate. Neither the saturated aldehyde acetaldehyde nor H2O2 evoked IL-8 release. In addition, CSE or crotonaldehyde upregulated the release of IL-8 from alveolar macrophages from both COPD patients and healthy nonsmokers, indicating that this is a response common to cells involved in lung inflammation. CSE-evoked IL-8 release was accompanied by increased phosphorylation of p38 MAPK and ERK1/2. CSE-evoked p38 and ERK1/2 phosphorylation was mimicked by acrolein and inhibited by NAC. IL-8 release elicited by both acrolein and CSE was blocked by pharmacological inhibition of p38 and ERK1/2 phosphorylation. In summary, our data show that α,β-unsaturated aldehydes-evoked phosphorylation of p38 and ERK1/2 underlies IL-8 release elicited by CSE, thus shedding light on the mechanisms through which cigarette smoke can initiate inflammation in the lung.
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Sapkota, Muna, Kusum K. Kharbanda, and Todd A. Wyatt. "Malondialdehyde-Acetaldehyde-Adducted Surfactant Protein Alters Macrophage Functions Through Scavenger Receptor A." Alcoholism: Clinical and Experimental Research 40, no. 12 (2016): 2563–72. http://dx.doi.org/10.1111/acer.13248.

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Bao, Hui-Fang, John Z. Song, Billie J. Duke, He-Ping Ma, Donald D. Denson, and Douglas C. Eaton. "Ethanol stimulates epithelial sodium channels by elevating reactive oxygen species." American Journal of Physiology-Cell Physiology 303, no. 11 (2012): C1129—C1138. http://dx.doi.org/10.1152/ajpcell.00139.2012.

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Alcohol affects total body sodium balance, but the molecular mechanism of its effect remains unclear. We used single-channel methods to examine how ethanol affects epithelial sodium channels (ENaC) in A6 distal nephron cells. The data showed that ethanol significantly increased both ENaC open probability ( Po) and the number of active ENaC in patches ( N). 1-Propanol and 1-butanol also increased ENaC activity, but iso-alcohols did not. The effects of ethanol were mimicked by acetaldehyde, the first metabolic product of ethanol, but not by acetone, the metabolic product of 2-propanol. Besides increasing open probability and apparent density of active channels, confocal microscopy and surface biotinylation showed that ethanol significantly increased α-ENaC protein in the apical membrane. The effects of ethanol on ENaC Po and N were abolished by a superoxide scavenger, 4-hydroxy-2,2,6,6-tetramethylpiperidinyloxy (TEMPOL) and blocked by the phosphatidylinositol 3-kinase inhibitor LY294002. Consistent with an effect of ethanol-induced reactive oxygen species (ROS) on ENaC, primary alcohols and acetaldehyde elevated intracellular ROS, but secondary alcohols did not. Taken together with our previous finding that ROS stimulate ENaC, the current results suggest that ethanol stimulates ENaC by elevating intracellular ROS probably via its metabolic product acetaldehyde.
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Willis, Monte S., Geoffrey M. Thiele, Dean J. Tuma, and Lynell W. Klassen. "T cell proliferative responses to malondialdehyde–acetaldehyde haptenated protein are scavenger receptor mediated." International Immunopharmacology 3, no. 10-11 (2003): 1381–99. http://dx.doi.org/10.1016/s1567-5769(03)00136-x.

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Willis, Monte S., Lynell W. Klassen, Deborah L. Carlson, Chad F. Brouse, and Geoffrey M. Thiele. "Malondialdehyde–acetaldehyde haptenated protein binds macrophage scavenger receptor(s) and induces lysosomal damage." International Immunopharmacology 4, no. 7 (2004): 885–99. http://dx.doi.org/10.1016/j.intimp.2004.04.004.

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Berger, John P., Samantha M. Simet, Jane M. DeVasure, et al. "Malondialdehyde-acetaldehyde (MAA) adducted proteins bind to scavenger receptor A in airway epithelial cells." Alcohol 48, no. 5 (2014): 493–500. http://dx.doi.org/10.1016/j.alcohol.2014.02.005.

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Dissertations / Theses on the topic "Acetaldehyde Scavengers"

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Mrozinski, Brent A. "Acetaldehyde Scavengers for Poly(ethylene terephthalate): Chemistry of Reactions, Capacity, and Modeling of Interactions." University of Toledo / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1288955969.

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Araújo, Stefano Mota. "Revestimentos para reduzir os odores no ambiente." Master's thesis, 2014. http://hdl.handle.net/1822/35482.

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Dissertação de mestrado integrado em Engenharia Biológica (área de especialização em Tecnologia Química e Alimentar)<br>A Organização Mundial de Saúde (OMS) reconheceu a poluição do ar interior como sendo o quarto problema ambiental mais crucial do planeta. Em ambientes interiores existem diversas fontes emissoras de odores como processos de combustão ou fumos emitidos durante a realização de cozinhados, fumo do cigarro e presença de animais de estimação que, por sua vez, perturbam a qualidade do ar. Deste modo, aliada também à maior exigência por parte dos consumidores na utilização de revestimentos, o presente trabalho teve como principal objetivo o desenvolvimento de tintas que permitam reduzir os odores presentes no ambiente interior e, por conseguinte, contribuam para a melhoria da sua qualidade. Complementarmente, o projeto teve também como objetivo implementar métodos experimentais que permitam avaliar o nível de captação dos odores. Entre os vários compostos químicos associados às fontes emissoras de odores, os compostos orgânicos voláteis (COV) constituem os principais poluentes químicos, onde o formaldeído e o acetaldeído se destacam como os mais nocivos para a saúde humana. Os revestimentos estudados foram reproduzidos com material não captador (Resina A) e com diferentes materiais captadores de odores (Resina B, C e D), incorporados nas mesmas proporções na formulação dos revestimentos. De seguida, os mesmos foram submetidos a ensaios de captação dos compostos químicos associados aos odores, sendo a capacidade de captação quantificada através do método do exsicador (JIS A 1460:2001) com os COV determinados por espectrofotometria e pelo método adaptado de ensaio interno em vials e em serum bottles por cromatografia gasosa (GC) com detetor de ionização de chama (FID). Para cada material testado foi estudada a influência do tempo de secagem da película de tinta na capacidade de captação. No que diz respeito ao método do exsicador, a Resina C incorporada na tinta foi o material que apresentou maior capacidade de captação dos compostos químicos associados aos odores. No caso do método adaptado de ensaio interno, as tintas reproduzidas com as Resinas C e D foram as que apresentaram maior capacidade de captação. Por outro lado, tendo em conta o composto analisado e o tempo de secagem das películas de tinta, constatou-se, na maior parte dos ensaios, que os revestimentos apresentaram um maior poder de captação para o composto formaldeído e para películas com um maior tempo de secagem. Assim, concluiu-se que a tinta reproduzida com a Resina C constitui o revestimento com maior potencial para reduzir os odores em ambientes interiores, apresentando boas características de resistência e aplicabilidade (apesar da formulação não se encontrar totalmente otimizada).<br>The World Health Organization (WHO) has recognized indoor air pollution as the fourth most critical environmental problem in the world. In indoor environments there are several odour emission sources, such as combustion processes or cooking activities, cigarette smoke and presence of domestic animals, which harm the quality of indoor air. Thus, also allied to greater demand from consumers in the use of coatings, this study had as the main objective the development of paints that allow reducing odours present in indoor environment, thereby making it healthier and cleaner. Furthermore, the project also had as objective the implementation of experimental methods to assess the level of reduction capacity. Among the various chemicals associated with the sources of odours, VOCs are the main pollutants, where formaldehyde and acetaldehyde stand out as the most harmful to human health. The paints studied were reproduced with a material without odour removal ability (Resin A) and with different odour scavengers (Resin B, C and D), incorporated in the same amounts. Then, they were tested in terms of decreasing the chemical compounds associated with odours and, subsequently, the reduction capacity was quantified by the desiccator method (JIS A 1460: 2001) per spectrophotometry and by adapted method of internal assay in vials and serum bottles per gas chromatography (GC) with flame ionization detector (FID). For each type of scavenger was studied the influence of the drying time of the paint film. Regarding to the desiccator method, the resin C incorporated in the paint was the material that showed a higher reduction capacity of chemical compounds related to odour. In the case of the adapted method of internal assay, the paints reproduced with the resins C and D showed the highest reduction capacity. Moreover, taking into account the drying time of the paint film and the analysed chemical compound, it was observed, for most assays, that the coatings had a greater potential to reduce chemical compounds for films with a longer drying time and for formaldehyde compound. In summary, it was concluded that the paint reproduced with the resin C shows the greatest potential for lowering the odours present in indoor environments, presenting good characteristics of resistance and applicability (although the formulation is not yet fully optimized).
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Book chapters on the topic "Acetaldehyde Scavengers"

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Gehring, Carina, and Frank Welle. "Migration of Acetaldehyde Scavengers From PET Bottles." In Reference Module in Food Science. Elsevier, 2017. http://dx.doi.org/10.1016/b978-0-08-100596-5.21428-5.

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Conference papers on the topic "Acetaldehyde Scavengers"

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Berger, John P., Samantha M. Simet, Joseph H. Sisson, and Todd A. Wyatt. "Malondialdehyde-Acetaldehyde Adducted Protein Binds To Scavenger Receptor-A On Bronchial Epithelial Cells." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2093.

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