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Journal articles on the topic 'Acetaminophen'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Myers, Wade C., Terrance A. Otto, Elaine Harris, Daniel Diaco, and Anthony Moreno. "ACETAMINOPHEN OVERDOSE AS A SUICIDAL GESTURE: A SURVEY OF ADOLESCENTS' KNOWLEDGE OF ITS POTENTIAL FOR TOXICITY." Pediatrics 93, no. 6 (1994): A36. http://dx.doi.org/10.1542/peds.93.6.a36.

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Acetaminophen is a popular nonprescription analgesic that is often taken in overdose by adolescents during suicidal gestures. The authors hypothesized that most adolescents are naive about the toxic and lethal potential of acetaminophen in overdose. A one-page, 12-item questionnaire was administered to 169 high school students to evaluate their perceptions and knowledge in this area. Whereas only 22% of the sample underestimated the dose of acetaminophen necessary to cause harm, 40.5% underestimated the potential lethality of acetaminophen in overdose. Moreover, 17% of the sample did not belie

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S.T., Schultz. "Can autism be triggered by acetaminophen activation of the endocannabinoid system?" Acta Neurobiologiae Experimentalis 70, no. 2 (2010): 227–31. http://dx.doi.org/10.55782/ane-2010-1793.

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Acetaminophen use in children has been associated with increased autism risk. Recent evidence suggests that acetaminophen's analgesic actions result from activation of the endocannabinoid system, and activation of this system can have neuromodulatory consequences during development. This investigation was performed to determine if there is evidence to support the hypothesis that acetaminophen use can trigger autism by activation of the endocannabinoid system.

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Thibault, Céline, Élaine Pelletier, Christina Nguyen, et al. "The Three W's of Acetaminophen In Children: Who, Why, and Which Administration Mode?" Journal of Pediatric Pharmacology and Therapeutics 28, no. 1 (2023): 20–28. http://dx.doi.org/10.5863/1551-6776-28.1.20.

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Acetaminophen is one of the oldest medications commonly administered in children. Its efficacy in treating fever and pain is well accepted among clinicians. However, the available evidence supporting the use of acetaminophen's different modes of administration remains relatively scarce and poorly known. This short report summarizes the available evidence and provides a framework to guide clinicians regarding a rational use of acetaminophen in children.

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Keaveney, Alexis, Ellen Peters, and Baldwin Way. "Effects of acetaminophen on risk taking." Social Cognitive and Affective Neuroscience 15, no. 7 (2020): 725–32. http://dx.doi.org/10.1093/scan/nsaa108.

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Abstract Acetaminophen, an analgesic and antipyretic available over-the-counter and used in over 600 medicines, is one of the most consumed drugs in the USA. Recent research has suggested that acetaminophen’s effects extend to the blunting of negative as well as positive affect. Because affect is a determinant of risk perception and risk taking, we tested the hypothesis that acute acetaminophen consumption (1000 mg) could influence these important judgments and decisions. In three double-blind, placebo-controlled studies, healthy young adults completed a laboratory measure of risk taking (Ball

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Harris, Hope Elaine, and Wade C. Myers. "Adolescents' Misperceptions of the Dangerousness of Acetaminophen in Overdose." Suicide and Life-Threatening Behavior 27, no. 3 (1997): 274–77. http://dx.doi.org/10.1111/j.1943-278x.1997.tb00409.x.

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Clinical observations suggest that adolescents commonly and naively use acetaminophen in suicide attempts even when they do not wish to die. It is estimated that 18 500‐mg acetaminophen tablets can lead to hepatotoxicity, while death is usually associated with ingestion of 50 or more tablets. A sample comprising 569 adolescent students completed an author‐designed survey assessing teenagers' knowledge of acetaminophen's therapeutic and harmful effects. The findings support our original data that adolescents have ready access to acetaminophen and use it in suicide attempts, but underestimate it

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Sahara, Mia Putri, Siska Julia Cindy Winangsih, Siti Jaisy Millah Hadaina, Komang Pranayoga Prandhana Putra, Rizqi Al Kasiron, and Catarina Budyono. "Tatalaksana Non-Acetaminophen Induced Acute Liver Failure Dengan Menggunakan Nacetylcysteine." Unram Medical Journal 11, no. 4 (2022): 1183–86. http://dx.doi.org/10.29303/jk.v11i4.4750.

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Gagal hati akut merupakan suatu kondisi dimana terjadi disfungsi hati yang bersifat akut. Terdapat dua jenis dari gagal hati akut ini yaitu acetaminophen induced acute liver failure dan non acetaminophen induced acute liver failure.Gagal hati akut memiliki penilaian angka insidensi sebanyak 1-6 kasus per 1 juta orang setiap tahunnya pada berbagai negara maju, sedangkan untuk Negara berkembang penilaian angka insidensi diperkiraan lebih besar karena memiliki angka insidensi hepatitis yang tinggi, di Amerika, diperkirakan sebanyak 2500 kasus gagal hati akut per tahunnya. Sampai saat ini, tidak a

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Sahara, Mia Putri. "Tatalaksana Non-Acetaminophen Induced Acute Liver Failure Dengan Menggunakan N-acetylcysteine." Unram Medical Journal 11, no. 4 (2022): 1183–86. http://dx.doi.org/10.29303/jku.v11i4.801.

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Gagal hati akut merupakan suatu kondisi dimana terjadi disfungsi hati yang akut. Terdapat dua jenis akut dari gagal hati akut ini yaitu acetaminophen induced acute liver failure dan non acetaminophen induced acute liver failure.Gagal hati memiliki penilaian angka insidensi sebanyak 1-6 kasus per 1 juta setiap tahun pada berbagai negara maju, sedangkan untuk Negara berkembang angka insidensi diperkiraan lebih besar karena memiliki angka insidensi hepatitis yang tinggi, di Amerika, diperkirakan sebanyak 2.500 kasus gagal hati akut per tahun. Sampai saat ini, tidak ada pengobatan yang mampu untuk

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8

Osahon Stanley Usiobeigbe, Kingsley O. Airhomwanbor, Lucky Eromosele Omolumen, Raphael O. Ikyaagba, Ernest Asibor, and Daniella Damilola Ogunsina. "Effects of Garnoderma lucidum on Acetaminophen-Induced Liver Injury in Wistar Rats." World Journal of Advanced Research and Reviews 21, no. 3 (2024): 2599–608. http://dx.doi.org/10.30574/wjarr.2024.21.3.0977.

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Introduction: Ganoderma lucidum is considered to be a medicinal mushroom, widely used to prevent or treat different types of diseases including cancer, cardiovascular disease and hepatic dysfunction. This study aimed to evaluate the effect of Ganoderma lucidum on acetaminophen-induced liver injury in wistar rats. Methods: Forty (40) male wistar rats were used for this study. Hepatoxicity was induced by oral administration of acetaminophenn (3000 mg/kg of body weight) for the last 21 consecutive days of the dietary of regimen Ganoderma lucidum. These rats were divided into eight cages each cont

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Osahon, Stanley Usiobeigbe, O. Airhomwanbor Kingsley, Eromosele Omolumen Lucky, O. Ikyaagba Raphael, Asibor Ernest, and Damilola Ogunsina Daniella. "Effects of Garnoderma lucidum on Acetaminophen-Induced Liver Injury in Wistar Rats." World Journal of Advanced Research and Reviews 21, no. 3 (2024): 2599–608. https://doi.org/10.5281/zenodo.14182157.

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<strong>Introduction: </strong><em>Ganoderma lucidum</em> is considered to be a medicinal mushroom, widely used to prevent or treat different types of diseases including cancer, cardiovascular disease and hepatic dysfunction. This study aimed to evaluate the effect of <em>Ganoderma</em> <em>lucidum</em> on acetaminophen-induced liver injury in wistar rats. <strong>Methods</strong>: Forty (40) male wistar rats were used for this study. Hepatoxicity was induced by oral administration of acetaminophenn (3000 mg/kg of body weight) for the last 21 consecutive days of the di

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Iqbal, Sohail, Rao Salman Aziz, Liaquat Ali, et al. "ACETAMINOPHEN." Professional Medical Journal 25, no. 12 (2018): 1923–27. http://dx.doi.org/10.29309/tpmj/18.4807.

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Introduction: Nephrotoxicity is an important side effect of many medicine and chemotherapeutic agents. Active ingredients from natural sources have shown promising results to alleviate these side effects. Objectives: We aimed to investigate the effects of aqueous Date fruit extract in animal model of paracetamol induced nephrotoxicity in rats. Study Design: Experimental. Setting: Sargodha Institute of Health Sciences Sargodha. Period: January 2017-September 2017. Material & Methods: 30 rats were randomly divided into five groups treatment groups. Treatments were given daily for two weeks.

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Anker, Anthony L., and Martin J. Smilkstein. "Acetaminophen." Emergency Medicine Clinics of North America 12, no. 2 (1994): 335–49. http://dx.doi.org/10.1016/s0733-8627(20)30431-4.

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Turkoski, Beatrice B. "Acetaminophen." Orthopaedic Nursing 29, no. 1 (2010): 41–43. http://dx.doi.org/10.1097/nor.0b013e3181c8cd75.

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&NA;. "Acetaminophen." Orthopaedic Nursing 29, no. 1 (2010): 44–45. http://dx.doi.org/10.1097/nor.0b013e3181cd36aa.

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Rajpal, Bhumika, Manas Mitra, Arun Kaushik, and Kishalay Datta. "Acetaminophen Ingestion Turns Toxic." Indian Journal of Emergency Medicine 9, no. 3 (2023): 123–26. http://dx.doi.org/10.21088/ijem.2395.311x.9323.14.

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Acetaminophen, commonly called “Paracetamol” is an over the counter medication available in all the pharmacies in the Indian subcontinent. The emergency and critical care department is commonly involved in the diagnosis and treatment of acetaminophen poisoning patients. The treatment guidelines are ages old but in recent times, the presentation for acetaminophen poisoning has been varied. In this case report, we will discuss the diagnosis and management of acetaminophen poisoning in a child, along with review of literature.

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Bertholf, Roger L., Laura M. Johannsen, Alireza Bazooband, and Vafa Mansouri. "False-Positive Acetaminophen Results in a Hyperbilirubinemic Patient." Clinical Chemistry 49, no. 4 (2003): 695–98. http://dx.doi.org/10.1373/49.4.695.

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Abstract Background: Acetaminophen was falsely detected in the plasma of a severely jaundiced patient, and a methodologic interference from bilirubin was suspected. Methods: Acetaminophen was measured by an enzymatic method (GDS Diagnostics). The putative bilirubin interference was investigated in 12 hyperbilirubinemic specimens and in bilirubin linearity calibrators. The analytical method was modified to correct for background absorbance at a second wavelength. Hyperbilirubinemic specimens were fortified with acetaminophen to assess the effect of the interference on acetaminophen measurements

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Chan, Thomas YK. "Interactions of Acetaminophen, Opiates, and Their Combinations with Warfarin and other Oral Anticoagulants." Journal of Pharmacy Technology 13, no. 2 (1997): 89–92. http://dx.doi.org/10.1177/875512259701300211.

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Objective: To determine whether acetaminophen, opiates, or acetaminophen–opiate combinations potentiate the effect of warfarin. Data Sources: Previous studies or reports of interactions between warfarin and acetaminophen, opiates, or acetaminophen–opiate combinations (MEDLINE search, January 1976 to January 1996). Study Selection: All articles were included in the review. Pertinent information was selected for discussion. Data Synthesis: Studies of the effects of acetaminophen on anticoagulation with warfarin and other oral anticoagulants have yielded conflicting results. In three placebo-cont

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Jo, Seung Jik, Hyun Young Gang, Si Jin Lee, et al. "Continuous Control of Acetaminophen Poisoning after Implementation of Regulation for Ease Access of Acetaminophen: Cohort Study from Emergency Department Based in-depth Injury Surveillance." Journal of The Korean Society of Clinical Toxicology 18, no. 2 (2020): 57–65. http://dx.doi.org/10.22537/jksct.2020.18.2.57.

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Purpose: Since 2012, acetaminophen can be accessed easily not only at pharmacies but also at convenience stores. The relationship between the easy access of acetaminophen and the risk of poisoning has been controversial. Several studies also reported different results regarding the risk of acetaminophen poisoning after access to acetaminophen was relaxed. This study examined the long-term effects on the risk of acetaminophen poisoning after easy access to acetaminophen was implemented. Methods: This was a retrospective analysis of an emergency department (ED)-based in-depth Injury Surveillance

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Bentur, Yedidia, Yael Lurie, Ada Tamir, Daniel C. Keyes, and Fuad Basis. "Reliability of history of acetaminophen ingestion in intentional drug overdose patients." Human & Experimental Toxicology 30, no. 1 (2010): 44–50. http://dx.doi.org/10.1177/0960327110366784.

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The objective of this study was to determine the reliability of denial of acetaminophen ingestion in intentional drug overdose patients. All intentional drug overdose patients admitted to an emergency department who were able to provide a history were included. A detailed history was obtained on names, timing and number of medications ingested, and serum acetaminophen was assayed. Multidrug ingestion was defined as the reporting of ≥2 medications. Patients were considered ‘reliable’ if they reported acetaminophen ingestion and had detectable acetaminophen levels or the other way around. Validi

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Arun, Oguzhan, Ozgur Canbay, Nalan Celebi, et al. "The Analgesic Efficacy of Intra-Articular Acetaminophen in an Experimental Model of Carrageenan-Induced Arthritis." Pain Research and Management 18, no. 5 (2013): e63-e67. http://dx.doi.org/10.1155/2013/148392.

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BACKGROUND: Acetaminophen is one of the most common drugs used for the treatment of pain and fever.OBJECTIVES: To examine the effects of intra-articular (IA) acetaminophen on carrageenan-induced arthritic pain-related behaviour and spinal c-Fos expression in rats.METHODS: The present study was performed using 20 Sprague Dawley rats. Forty microlitres of IA 0.9% NaCl was injected in the control group, and 40 μL of IA carrageenan was injected in the carrageenan group. One hour after carrageenan injection, 400 μg of IA acetaminophen was injected in the IA acetaminophen group, and 400 μg of intrap

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Srikanth, Chittur V., Asit K. Chakraborti, and Anand K. Bachhawat. "Acetaminophen toxicity and resistance in the yeast Saccharomyces cerevisiae." Microbiology 151, no. 1 (2005): 99–111. http://dx.doi.org/10.1099/mic.0.27374-0.

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Acetaminophen (paracetamol), one of the most widely used analgesics, is toxic under conditions of overdose or in certain disease conditions, but the mechanism of acetaminophen toxicity is still not entirely understood. To obtain fresh insights into acetaminophen toxicity, this phenomenon was investigated in yeast. Acetaminophen was found to be toxic to yeast cells, with erg mutants displaying hypersensitivity. Yeast cells grown in the presence of acetaminophen were found to accumulate intracellular acetaminophen, but no metabolic products of acetaminophen could be detected in these extracts. T

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Holubek, William J., and Lewis S. Nelson. "Acetaminophen Protein Adducts: Is Acetaminophen to Blame?" Gastroenterology 131, no. 4 (2006): 1360. http://dx.doi.org/10.1053/j.gastro.2006.08.056.

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Patel, Anita K., Jiaxiang Gai, Eduardo Trujillo-Rivera, et al. "National Intravenous Acetaminophen Use in Pediatric Inpatients From 2011–2016." Journal of Pediatric Pharmacology and Therapeutics 27, no. 4 (2022): 358–65. http://dx.doi.org/10.5863/1551-6776-27.4.358.

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OBJECTIVE To 1) determine current intravenous (IV) acetaminophen use in pediatric inpatients; and 2) determine the association between opioid medication duration when used with or without IV acetaminophen. METHODS A retrospective analysis of pediatric inpatients exposed to IV acetaminophen from January 2011 to June 2016, using the national database Health Facts. RESULTS Eighteen thousand one hundred ninety-seven (2.0%) of 893,293 pediatric inpatients received IV acetaminophen for a median of 14 doses per patient (IQR, 8–56). A greater proportion of IV acetaminophen patients were admitted to th

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Taylor, Brock M., Shawn R. Chakraborty, Aaron A. Harthan, Sandeep Tripathi, Huaping Wang, and Anil Kumar Swayampakula. "Effect of IV Acetaminophen Usage on Opioid Requirements, Outcomes and Costs of Care for Postoperative Children in a Pediatric Intensive Care Unit." Journal of Pediatric Pharmacology and Therapeutics 25, no. 6 (2020): 514–20. http://dx.doi.org/10.5863/1551-6776-25.6.514.

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OBJECTIVE Children admitted to the ICU are commonly treated with opioids for postoperative pain. We hypothesized that administration of IV acetaminophen in the immediate postoperative period is effective in lowering cumulative opioid use leading to other benefits. METHODS This was a retrospective chart review of patients admitted to the PICU between December 2016 and April 2019. For each patient, data including demographics, cumulative opioid usage per kilogram, oral or rectal acetaminophen, x-ray findings, hospital costs, and surgical procedure were collected. Cumulative opioid usage was dete

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Nabavi, Nima, Mohammad Moshiri, Shahrad Tajoddini, and Bita Dadpour. "A Basis for the Decision to Rule in or out Acetaminophen Toxicity: Assessment of the Serum Level Within 4 Hours Post Overdose." Iranian Journal of Toxicology 15, no. 4 (2021): 265–70. http://dx.doi.org/10.32598/ijt.15.4.820.1.

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Background: Acetaminophen is a popular antipyretic and analgesic medication worldwide; however, its therapeutic window is narrow, which may lead to overdose or toxicity. This study was conducted to assess the correlation between the serum acetaminophen levels before and 4 hours after the acute toxicity with this drug. The objective of this study was to test the validity of the serum level to arrive at a clinical decision on the toxicity with acetaminophen. Methods: This cross-sectional study was performed on patients hospitalized and treated with a diagnosis of acute acetaminophen overdose dur

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Yao, Hsien-Tsung, Chien-Chun Li, and Chen-Hui Chang. "Epigallocatechin-3-Gallate Reduces Hepatic Oxidative Stress and Lowers CYP-Mediated Bioactivation and Toxicity of Acetaminophen in Rats." Nutrients 11, no. 8 (2019): 1862. http://dx.doi.org/10.3390/nu11081862.

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Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenol in green tea. To investigate the effects of dietary EGCG on oxidative stress and the metabolism and toxicity of acetaminophen in the liver, rats were fed diets with (0.54%) or without EGCG supplementation for four weeks and were then injected intraperitoneally with acetaminophen (1 g/kg). The results showed that EGCG lowered hepatic oxidative stress and cytochrome P450 (CYP) 1A2, 2E1, and 3A, and UDP-glucurosyltransferase activities prior to acetaminophen injection. After acetaminophen challenge, the elevations in plasma alanine

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Kis, Bela, James A. Snipes, Steve A. Simandle, and David W. Busija. "Acetaminophen-sensitive prostaglandin production in rat cerebral endothelial cells." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 288, no. 4 (2005): R897—R902. http://dx.doi.org/10.1152/ajpregu.00613.2004.

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Acetaminophen is a widely used antipyretic and analgesic drug whose mechanism of action has recently been suggested to involve inhibitory effects on prostaglandin synthesis via a newly discovered cyclooxygenase variant (COX-3). Because COX-3 expression is high in cerebral endothelium, we investigated the effect of acetaminophen on the prostaglandin production of cultured rat cerebral endothelial cells (CECs). Acetaminophen dose-dependently inhibited both basal and LPS-induced PGE2 production in CECs with IC50 values of 15.5 and 6.9 μM, respectively. Acetaminophen also similarly inhibited the s

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Tan, Huiling, Paul Stathakis, Benoj Varghese, Nicholas A. Buckley, and Angela L. Chiew. "Delayed Acetaminophen Absorption Resulting in Acute Liver Failure." Case Reports in Critical Care 2022 (May 7, 2022): 1–6. http://dx.doi.org/10.1155/2022/3672248.

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Introduction. Acetaminophen is a common medication involved in deliberate and accidental self-poisoning. The acetaminophen treatment nomogram is used to guide acetylcysteine treatment. It is rare to develop hepatotoxicity with an initial acetaminophen concentration below the nomogram line. We present a case of acetaminophen ingestion with an initial concentration below the nomogram line that developed hepatic failure, due to a delayed peak acetaminophen concentration secondary to coingesting medications that slow gastric emptying. Case Report. A 43-year-old (55 kg) female presented after inges

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Allen, Keith B., A. Michael Borkon, David J. Cohen, et al. "Intravenous Acetaminophen Improves Outcomes after Transapical Transcatheter Aortic Valve Replacement." Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery 13, no. 4 (2018): 287–91. http://dx.doi.org/10.1097/imi.0000000000000513.

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Objective Complications with opioid-based postoperative pain management have led to guideline recommendations for a multimodal analgesia strategy incorporating nonopioid agents. We evaluated the opioid-sparing effect of intravenous acetaminophen in patients undergoing transapical transcatheter aortic valve replacement. Methods A multimodal pain management strategy that incorporated intravenous acetaminophen was retrospectively evaluated in 43 patients undergoing transapical transcatheter aortic valve replacement between November 2012 and March 2014. Before intravenous acetaminophen formulary a

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Kim, Jee Hyun, Won-joon Jeong, Seung Ryu, et al. "Is it Adequate to Determine Acetaminophen Toxicity Solely on Patients' History? An Analysis on Clinical Manifestation of Intoxication Patients with Positive Serum Acetaminophen Concentrations." Journal of The Korean Society of Clinical Toxicology 15, no. 2 (2017): 94–100. http://dx.doi.org/10.22537/jksct.15.2.94.

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Purpose: Acute acetaminophen intoxication is a common occurrence that can cause lethal complications. In most domestic emergency departments, clinicians tend to treat acetaminophen intoxication based on patients' history alone, simply due to the lack of a rapid acetaminophen laboratory test. We performed a 20-month study of intoxication patients to determine the correlation between the history of patients and serum laboratory tests for acetaminophen. Methods: We took blood samples from 280 intoxication patients to evaluate whether laboratory findings detected traces of acetaminophen in the sam

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Maduka Chike Joachim, Onah Livinus Nnanyereugo, and Eze Obiechina Chijioke. "A randomized controlled study of intramuscular acetaminophen- diclofenac versus acetaminophen-pentazocine for pain relief during manual vacuum aspiration in university of Maiduguri teaching hospital." GSC Biological and Pharmaceutical Sciences 30, no. 3 (2025): 261–71. https://doi.org/10.30574/gscbps.2025.30.3.0114.

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The management of first trimester miscarriages using manual vacuum aspiration is a cheap, fast and safe surgical method of uterine evacuation. However, this procedure generate pain as a result of cervical manipulation, insertion of cannula and suctioning of uterine cavity. This pain quite often, is intolerable to the patient. Therefore, an effective pain management intervention is necessary to abolish this pain. Aim: The aim of this study was to compare combined acetaminophen-diclofenac with acetaminophen-pentazocine for pain relief during manual vacuum aspiration in a randomised controlled st

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Jones, John P., Lauren Williamson, Zacharoula Konsoula, Rachel Anderson, Kathryn J. Reissner, and William Parker. "Evaluating the Role of Susceptibility Inducing Cofactors and of Acetaminophen in the Etiology of Autism Spectrum Disorder." Life 14, no. 8 (2024): 918. http://dx.doi.org/10.3390/life14080918.

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More than 20 previously reported lines of independent evidence from clinical observations, studies in laboratory animal models, pharmacokinetic considerations, and numerous temporal and spatial associations indicate that numerous genetic and environmental factors leading to inflammation and oxidative stress confer vulnerability to the aberrant metabolism of acetaminophen during early development, leading to autism spectrum disorder (ASD). Contrary to this conclusion, multivariate analyses of cohort data adjusting for inflammation-associated factors have tended to show little to no risk of acet

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Ahmed, Hafsa, and Hamidullah. "Implications and future direction of the effect of reducing acetaminophen dosage in prescription combination drugs on mitigating hepatotoxicity." Journal of the Pakistan Medical Association 73, no. 12 (2023): 2524–25. http://dx.doi.org/10.47391/jpma.9763.

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Dear editor, Acetaminophen is the most widely used pain relief medication around the globe. It is used as an antipyretic and treat various medical ailments, including mild to moderate pain [1]. However, studies have shown that acetaminophen is associated with several adverse consequences, among which hepatotoxicity is the most pronounced [2]. However, despite its well know side-effects and risk of hepatotoxicity, acetaminophen is widely prescribed and its overdosing is a serious issue. Moreover, many combination of medications prescribed for pain relief do contain acetaminophen as its componen

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Stern, Stephan T., Mary K. Bruno, Gayle E. Hennig, Robert A. Horton, Jeanette C. Roberts, and Steven D. Cohen. "Contribution of acetaminophen-cysteine to acetaminophen nephrotoxicity in CD-1 mice: I. Enhancement of acetaminophen nephrotoxicity by acetaminophen-cysteine." Toxicology and Applied Pharmacology 202, no. 2 (2005): 151–59. http://dx.doi.org/10.1016/j.taap.2004.06.030.

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McPherson, Christopher, Caitlyn M. Luecke, Caren J. Liviskie, Brandy N. Zeller, and Zachary A. Vesoulis. "Acetaminophen Serum Concentrations in Infants Treated Intravenously for Patent Ductus Arteriosus." Journal of Pediatric Pharmacology and Therapeutics 24, no. 2 (2019): 134–37. http://dx.doi.org/10.5863/1551-6776-24.2.134.

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OBJECTIVE Although acetaminophen has emerged as a therapeutic option for treating hemodynamically significant patent ductus arteriosus (PDA) in preterm infants, limited data exist on pharmacodynamics. The objective of this research is to report serum acetaminophen concentrations at steady state in infants treated with intravenous acetaminophen for PDA and to examine associations with clinical outcomes. METHODS This retrospective study evaluated all infants admitted during the study period who received intravenous acetaminophen for the treatment of PDA. Acetaminophen dosing was 15 mg/kg every 6

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Sudyk, Roksolana, Kamal Safah, John Garber, Cristian Meghea, and Omayma Alshaarawy. "Association Between Acetaminophen Exposure in Pregnancy and Adverse Birth Outcomes [ID 751]." Obstetrics & Gynecology 145, no. 6S (2025): 1S. https://doi.org/10.1097/aog.0000000000005916.003.

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INTRODUCTION: It is estimated that 65% of women use acetaminophen during their pregnancy in the United States. Mounting evidence has indicated that acetaminophen exposure in pregnancy may affect fetal development, culminating in a consensus statement in Nature calling for increased vigilance. This prospective population study aims to understand the association between maternal acetaminophen use and adverse birth outcomes. METHODS: The population includes women aged 15–45 from the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-To-Be. First-trimester pregnant women were enrolled across

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Rumbeiha, Wilson K., Yu-Shang Lin, and Frederick W. Oehme. "Comparison of N-acetylcysteine and methylene blue, alone or in combination, for treatment of acetaminophen toxicosis in cats." American Journal of Veterinary Research 56, no. 11 (1995): 1529–33. http://dx.doi.org/10.2460/ajvr.1995.56.11.1529.

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SUMMARY Acetaminophen is widely used in human beings for analgesic purposes, but is one of the most frequent causes of poisoning in cats. Acetaminophen-poisoned cats develop methemoglobinemia and sometimes hepatic failure. To determine the benefit of using methylene blue, a treatment for methemoglobinemia, along with N-acetylcysteine (nac), the recommended treatment for acetaminophen-poisoned cats, groups of 3 male and 3 female cats each were given methylene blue nac, or both after administration of acetaminophen (120 mg/kg of body weight, po). Male cats seemed more susceptible than female cat

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Wells, Peter G., Barry Wilson, Louise M. Winn, and Barry M. Lubek. "In vivo murine studies on the biochemical mechanism of acetaminophen cataractogenicity." Canadian Journal of Physiology and Pharmacology 73, no. 8 (1995): 1123–29. http://dx.doi.org/10.1139/y95-160.

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C57BL/6 and DBA/2 mice are, respectively, susceptible and resistant both to the induction of aryl hydrocarbon hydroxylase (cytochrome P450 1A1, or CYP1A1) and to the cataractogenicity of acetaminophen, which may involve its bioactivation to a toxic reactive intermediate, catalysed by P450 and (or) prostaglandin H synthase (PHS). Following induction of P450 using β-naphthoflavone, the cataractogenicity of acetaminophen (400 mg/kg ip) in C57BL/6 mice was reduced by pretreatment with the P450 inhibitors SKF 525A and metyrapone, the glutathione precursor N-acetylcysteine, the antioxidant vitamin E

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Burger, David M., Pieter L. Meenhorst, Cornells H. W. Koks, and Jos H. Beijnen. "Pharmacokinetics of Zidovudine and Acetaminophen in a Patient on Chronic Acetaminophen Therapy." Annals of Pharmacotherapy 28, no. 3 (1994): 327–30. http://dx.doi.org/10.1177/106002809402800306.

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OBJECTIVE: To report a case of a potential interaction between acetaminophen and zidovudine in a patient who had used high daily doses of acetaminophen over many years. CASE SUMMARY: A 43-year-old man presented with HIV-1 infection, recurrent oral candidiasis, and chronic use of acetaminophen, codeine, and diazepam before he started zidovudine therapy. Although literature was available regarding short-term combined use of acetaminophen and zidovudine, information was lacking on zidovudine therapy and kinetics after long-term use of acetaminophen. Acetaminophen and zidovudine pharmacokinetics w

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Maduka Chike Joachim, Onah Livinus Nnanyereugo, and Ezugwu Ifeanyi Anthony. "A comparative study of safety and patient satisfaction of combined intramuscular acetaminophen- diclofenac versus acetaminophen-pentazocine for pain relief during manual vacuum aspiration in university of Maiduguri teaching hospital: Randomised controlled." World Journal of Biology Pharmacy and Health Sciences 22, no. 1 (2025): 242–52. https://doi.org/10.30574/wjbphs.2025.22.1.0378.

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Background. The management of first trimester miscarriages using manual vacuum aspiration is a cheap, fast and safe surgical method of uterine evacuation. However, this procedure cause pain as a result of cervical manipulation, insertion of cannula and suctioning of uterine cavity. Therefore, an effective and safe pain management intervention is necessary to minimise this pain and reduces side effect of the medication. Objective: To determine and compare the side effects and participants’ satisfaction of combined acetaminophen-diclofenac versus acetaminophen-pentazocine for pain relief during

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Young, Malcolm A., Sally Lettis, and Richard Eastmond. "Coadministration of Acetaminophen and Troglitazone: Pharmacokinetics and Safety." Journal of Clinical Pharmacology 38, no. 9 (1998): 819–24. http://dx.doi.org/10.1002/j.1552-4604.1998.tb00015.x.

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Troglitazone, a PPAR‐g agonist, enhances the actions of insulin on muscle and liver. It is metabolized predominantly in the liver to a sulfate conjugate and a quinone metabolite. Acetaminophen also undergoes metabolism by conjugation. This three‐way crossover study in 12 healthy male volunteers was conducted to investigate the effects of acetaminophen on the metabolism of troglitazone and vice versa. No statistically or clinically relevant differences in area under the concentrationtime curve extrapolated to infinity (AUC0‐∞ were observed for troglitazone, its quinone metabolite, or acetaminop

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Ishida, Yuko, Siying Zhang, Yumi Kuninaka, et al. "Essential Involvement of Neutrophil Elastase in Acute Acetaminophen Hepatotoxicity Using BALB/c Mice." International Journal of Molecular Sciences 24, no. 9 (2023): 7845. http://dx.doi.org/10.3390/ijms24097845.

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Intense neutrophil infiltration into the liver is a characteristic of acetaminophen-induced acute liver injury. Neutrophil elastase is released by neutrophils during inflammation. To elucidate the involvement of neutrophil elastase in acetaminophen-induced liver injury, we investigated the efficacy of a potent and specific neutrophil elastase inhibitor, sivelestat, in mice with acetaminophen-induced acute liver injury. Intraperitoneal administration of 750 mg/kg of acetaminophen caused severe liver damage, such as elevated serum transaminase levels, centrilobular hepatic necrosis, and neutroph

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Toda, Katsuhiro. "Is acetaminophen safe in pregnancy?" Scandinavian Journal of Pain 17, no. 1 (2017): 445–46. http://dx.doi.org/10.1016/j.sjpain.2017.09.007.

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AbstractAcetaminophen is thought to be the safest analgesic and antipyretic medicine for pregnant women, and it is widely used all over the world. However, prenatal acetaminophen was reported to be associated with asthma, lower performance intelligence quotient (IQ), shorter male infant anogenital distance (predicting poor male reproductive potential), autism spectrum disorder, neurodevelopmental problems (gross motor development, communication), attention-deficit/hyperactivity disorder, poorer attention and executive function, and behavioral problems in childhood. Each article has poor power

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Leshnower, Bradley G., Hiroaki Sakamoto, Ahmad Zeeshan, et al. "Role of acetaminophen in acute myocardial infarction." American Journal of Physiology-Heart and Circulatory Physiology 290, no. 6 (2006): H2424—H2431. http://dx.doi.org/10.1152/ajpheart.00962.2005.

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Acetaminophen, the active ingredient in Tylenol, is a widely used drug that is well known for its analgesic and antipyretic properties. Acetaminophen is a commonly used alternative to nonsteroidal anti-inflammatory drugs, which have recently been demonstrated to increase mortality after acute myocardial infarction (AMI). The safety and potential cardioprotective properties of acetaminophen in the setting of AMI have recently been investigated; however, the results from these studies have been inconclusive. Using both large (ovine) and small (rabbit) collateral-deficient animal models, we studi

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Waters, Eoin, Jiang Huai Wang, H. Paul Redmond, Qiong Di Wu, Elaine Kay, and David Bouchier-Hayes. "Role of taurine in preventing acetaminophen-induced hepatic injury in the rat." American Journal of Physiology-Gastrointestinal and Liver Physiology 280, no. 6 (2001): G1274—G1279. http://dx.doi.org/10.1152/ajpgi.2001.280.6.g1274.

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Acetaminophen overdose causes acute liver injury in both humans and animals. This study was designed to investigate the potential role of the conditionally essential amino acid taurine in preventing acetaminophen-induced hepatotoxicity. Male Sprague-Dawley rats were administered acetaminophen (800 mg/kg) intraperitoneally. Taurine (200 mg/kg) was given 12 h before, at the time of, and 1 or 2 h after acetaminophen injection. Acetaminophen treatment increased the plasma levels of aspartate transaminase, alanine aminotransferase, and alkaline phosphatase and caused hepatic DNA fragmentation and h

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Fusco, Nicholas M., Kristine Parbuoni, and Jill A. Morgan. "Drug Utilization, Dosing, and Costs After Implementation of Intravenous Acetaminophen Guidelines for Pediatric Patients." Journal of Pediatric Pharmacology and Therapeutics 19, no. 1 (2014): 35–41. http://dx.doi.org/10.5863/1551-6776-19.1.35.

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OBJECTIVES The objectives of this evaluation of medication use were to characterize the use of intravenous acetaminophen at our institution and to determine if acetaminophen was prescribed at age-appropriate dosages per institutional guidelines, as well as to evaluate compliance with restrictions for use. Total acquisition costs associated with intravenous acetaminophen usage is described as well. METHODS This retrospective study evaluated the use of acetaminophen in pediatric patients younger than 18 years of age, admitted to a tertiary care hospital, who received at least 1 dose of intraveno

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Orandi, Babak J., M. Chandler McLeod, Paul A. MacLennan, et al. "Association of FDA Mandate Limiting Acetaminophen (Paracetamol) in Prescription Combination Opioid Products and Subsequent Hospitalizations and Acute Liver Failure." JAMA 329, no. 9 (2023): 735. http://dx.doi.org/10.1001/jama.2023.1080.

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ImportanceIn January 2011, the US Food and Drug Administration (FDA) announced a mandate to limit acetaminophen (paracetamol) to 325 mg/tablet in combination acetaminophen and opioid medications, with manufacturer compliance required by March 2014.ObjectiveTo assess the odds of hospitalization and the proportion of acute liver failure (ALF) cases with acetaminophen and opioid toxicity prior to and after the mandate.Design, Setting, and ParticipantsThis interrupted time-series analysis used hospitalization data from 2007-2019 involving ICD-9/ICD-10 codes consistent with both acetaminophen and o

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Hashiba, Kimberlee A., Shane R. Wo, and Loren G. Yamamoto. "Taste of Clindamycin and Acetaminophen." Clinical Pediatrics 56, no. 2 (2016): 146–49. http://dx.doi.org/10.1177/0009922816657151.

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This study evaluated the taste palatability of liquid clindamycin and acetaminophen products on the market. Subjects rated the palatability of 3 clindamycin suspensions, 1 amoxicillin suspension (tasted twice), an acetaminophen elixir, and an acetaminophen suspension in a randomized blinded fashion on a 0 to 5 scale. Forty-six adults aged 20 to 82 years volunteered for this study. Means (and 95% confidence intervals) were as follows: amoxicillin-first taste 3.6 (3.3-3.9), amoxicillin-second taste 3.5 (3.2-3.7). Clindamycin Rising, Perrigo, Greenstone; 2.0 (1.6-2.5), 3.0 (2.7-3.3), and 2.2 (1.8

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Chiew, Angela L., and Nicholas A. Buckley. "Acetaminophen Poisoning." Critical Care Clinics 37, no. 3 (2021): 543–61. http://dx.doi.org/10.1016/j.ccc.2021.03.005.

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Nadler, Ariella, and Daniel M. Fein. "Acetaminophen Poisoning." Pediatrics in Review 39, no. 6 (2018): 316–18. http://dx.doi.org/10.1542/pir.2017-0093.

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Mortensen, M. E., and J. L. Cullen. "Acetaminophen Recommendation." PEDIATRICS 110, no. 3 (2002): 646. http://dx.doi.org/10.1542/peds.110.3.646.

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