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Journal articles on the topic 'Acetohydrazide'

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1

Hoan, Duong Quoc. "SYNTHESIS AND BIOLOGICAL ACTIVITY EVALUATION OF SOME DERIVATIVES SYNTHESIZED FROM CURCUMIN AND CURCUMIN ANALOG." Hue University Journal of Science: Natural Science 126, no. 1B (2017): 127. http://dx.doi.org/10.26459/hueuni-jns.v126i1b.4139.

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The acetohydrazides <strong>A5 </strong>containing an isoxazole ring and<strong> B5</strong> containing an indazole ring were synthesized from the corresponding acetohydrazide derivatives with acetic anhydride in about 80% high yield. Also, two acetohydrazones <strong>B6</strong> and <strong>B7</strong> were driven from acetohydrazide <strong>B4</strong> by condensation reaction. Bioactivity testes showed that none of them were active against on bacteria except acetohydrazones <strong>B7</strong> showing moderate reactivit
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2

Aleksandrova, K. V., Ye K. Mykhalchenko, O. S. Shkoda, and D. A. Vasyliev. "Synthesis and physical-chemical properties of (3-benzyl-8-propylxanthin-7-yl)acetohydrazide derivatives and their evaluation for antimicrobial and diuretic activities." Current issues in pharmacy and medicine: science and practice 14, no. 1 (2021): 17–22. http://dx.doi.org/10.14739/2409-2932.2021.1.226742.

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One of the most important tasks of our indigenous pharmaceutical science is the necessity for new medicines because existing drugs are characterized by various side effects, resistance, high toxicity, and so on. New bioactive molecule synthesis utilizes substances of natural origin as well as chemically modified ones. Thus, the researcher’s attention is mainly focused on 3-,7-,8-substituted derivatives of the natural heterocyclic xanthine system, which possess a wide range of pharmacological action. Synthesis of a novel of (3-benzyl-8-propylxanthin-7-yl)acetohydrazides with antimicrobial and d
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3

Fuloria, Neeraj Kumar, Vijender Singh, M. Shaharyar, and Mohd Ali. "SYNTHESIS AND ANTIMICROBIAL STUDIES OF NOVEL IMINES AND OXADIAZOLES." SOUTHERN BRAZILIAN JOURNAL OF CHEMISTRY 16, no. 16 (2008): 11–22. http://dx.doi.org/10.48141/sbjchem.v17.n17.2008.14_2008.pdf.

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N-benzylidene-2-(4-chloro-3-methylphenoxy)acetohydrazides (3a-e), obtained by arylation of 2-(4-chloro-3-methyl phenoxy)acetohydrazide (2), was cyclized with acetic anhydride to yield 1-(5-(( 4-chloro-3-methylphenoxy)methyl)-2-phenyl-l ,3,4-oxadiazol- 3(2H)-yl)ethanones (4a-e). All the newly synthesized compounds were analytically and spectrally characterized and evaluated for anti-bacterial and anti-fungal activities.
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4

Zhou, Bao-Han. "Acetohydrazide." Acta Crystallographica Section E Structure Reports Online 65, no. 11 (2009): o2821. http://dx.doi.org/10.1107/s1600536809042469.

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5

Mor, Satbir, Suchita Sindhu, Mohini Khatri, Ravinder Punia, and Komal Jakhar. "Synthesis, Type II diabetes inhibitory activity, antimicrobial evaluation, and docking studies of N'-arylidene-2-((7-methylbenzo[4,5]thiazolo[2,3-c] [1,2,4]triazol-3-yl)thio)acetohydrazides." European Journal of Chemistry 13, no. 4 (2022): 426–34. http://dx.doi.org/10.5155/eurjchem.13.4.426-434.2315.

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N'-Arylidene-2-((7-methylbenzo[4, 5]thiazolo[2,3-c][1, 2, 4]triazol-3-yl)thio)acetohydrazides (6a-j) were prepared by condensation of 2-((7-methylbenzo[4,5]thiazolo[2,3-c][1,2,4] triazol-3-yl)thio)acetohydrazide with appropriately substituted benzaldehydes in dry methanol and a catalytic amount of glacial acetic acid. The prepared compounds tested for in vitro Type II diabetes inhibition and antimicrobial (antibacterial and antifungal) activities employing α-amylase inhibition assay and the serial dilution method, respectively. Type II diabetes inhibitory assay results of all the tested deriva
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6

Lokanath, N. K., M. A. Sridhar, J. Shashidhara Prasad, H. S. Nagaraja, and P. Mohan Rao. "(2,4-Dichlorophenoxy)acetohydrazide." Acta Crystallographica Section C Crystal Structure Communications 54, no. 5 (1998): 669–70. http://dx.doi.org/10.1107/s0108270197018416.

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7

Vu Quoc, Trung, Linh Nguyen Ngoc, Duong Tran Thi Thuy, et al. "Crystal structure of two N′-(1-phenylbenzylidene)-2-(thiophen-3-yl)acetohydrazides." Acta Crystallographica Section E Crystallographic Communications 75, no. 8 (2019): 1090–95. http://dx.doi.org/10.1107/s2056989019008892.

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The synthesis, spectroscopic data, crystal and molecular structures of two N′-(1-phenylbenzylidene)-2-(thiophen-3-yl)acetohydrazides, namely N′-[1-(4-hydroxyphenyl)benzylidene]-2-(thiophen-3-yl)acetohydrazide, C13H10N2O2S, (3a), and N′-[1-(4-methoxyphenyl)benzylidene]-2-(thiophen-3-yl)acetohydrazide, C14H14N2O2S, (3b), are described. Both compounds differ in the substituent at the para position of the phenyl ring: –OH for (3a) and –OCH3 for (3b). In (3a), the thiophene ring is disordered over two orientations with occupancies of 0.762 (3) and 0.238 (3). The configuration about the C=N bond is
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8

SOGO, Masahiro. "2-(Trimethylammonio)acetohydrazide Chloride." Journal of Synthetic Organic Chemistry, Japan 52, no. 6 (1994): 539–40. http://dx.doi.org/10.5059/yukigoseikyokaishi.52.539.

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9

Lv, Lu-Ping, Tie-Ming Yu, Wen-Bo Yu, Wei-Wei Li, and Xian-Chao Hu. "N′-(3,4-Dimethoxybenzylidene)acetohydrazide." Acta Crystallographica Section E Structure Reports Online 65, no. 8 (2009): o1989. http://dx.doi.org/10.1107/s1600536809027366.

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10

Zhou, Bao-Cheng, Lu-Ping Lv, Wen-Bo Yu, Wei-Wei Li, and Xian-Chao Hu. "N′-(3,4-Dimethoxybenzylidene)acetohydrazide." Acta Crystallographica Section E Structure Reports Online 65, no. 8 (2009): o1964. http://dx.doi.org/10.1107/s1600536809028608.

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11

Lv, Lu-Ping, Tie-Ming Yu, Wen-Bo Yu, Wei-Wei Li, and Xian-Chao Hu. "N′-(3-Methoxybenzylidene)acetohydrazide." Acta Crystallographica Section E Structure Reports Online 65, no. 8 (2009): o1990. http://dx.doi.org/10.1107/s1600536809028864.

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12

Li, Wei-Wei, Lu-Ping Lv, Wen-Bo Yu, Yong-Zhao Zhang, and Xian-Chao Hu. "N′-(3,4-Dihydroxybenzylidene)acetohydrazide." Acta Crystallographica Section E Structure Reports Online 65, no. 9 (2009): o2097. http://dx.doi.org/10.1107/s1600536809030712.

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13

Fun, Hoong-Kun, Chin Sing Yeap, Shridhar Malladi, Mahesh Padaki, and Arun M. Isloor. "2-(4-Methylanilino)acetohydrazide." Acta Crystallographica Section E Structure Reports Online 65, no. 9 (2009): o2234. http://dx.doi.org/10.1107/s1600536809033169.

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14

Lv, Lu-Ping, Tie-Ming Yu, Wen-Bo Yu, Wei-Wei Li, and Xian-Chao Hu. "N′-(2-Furylmethylene)acetohydrazide." Acta Crystallographica Section E Structure Reports Online 65, no. 9 (2009): o2272. http://dx.doi.org/10.1107/s1600536809033571.

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15

Zia-ur-Rehman, Muhammad, Mark R. J. Elsegood, Shahid Mahmud, and Hamid Latif Siddiqui. "N′-(2,4-Dinitrophenyl)acetohydrazide." Acta Crystallographica Section E Structure Reports Online 64, no. 8 (2008): o1441. http://dx.doi.org/10.1107/s1600536808019685.

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16

Salim, Muhammad, Zaid Mahmood, M. Nawaz Tahir, Saeed Ahmad, and Muhammad Yaseen. "2-(3,4-Dimethylanilino)acetohydrazide." Acta Crystallographica Section E Structure Reports Online 65, no. 10 (2009): o2595. http://dx.doi.org/10.1107/s1600536809038963.

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17

Dutkiewicz, Grzegorz, C. S. Chidan Kumar, B. Narayana, H. S. Yathirajan, and Maciej Kubicki. "2-(4-Chlorophenoxy)acetohydrazide." Acta Crystallographica Section E Structure Reports Online 65, no. 12 (2009): o3189. http://dx.doi.org/10.1107/s1600536809049538.

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18

Fun, Hoong-Kun, Ching Kheng Quah, Arun M. Isloor, Dhanya Sunil, and Prakash Shetty. "2-(2-Chlorophenoxy)acetohydrazide." Acta Crystallographica Section E Structure Reports Online 66, no. 1 (2009): o31—o32. http://dx.doi.org/10.1107/s1600536809051356.

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19

Yu, Tie-Ming, and Lu-Ping Lv. "N′-(2-Methoxybenzylidene)acetohydrazide." Acta Crystallographica Section E Structure Reports Online 66, no. 10 (2010): o2666. http://dx.doi.org/10.1107/s1600536810038092.

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20

Yang, Jie, Zhao-De Jiang, Fu-Gong Zhang, and Fang-Fang Jian. "N′-(2-Fluorobenzylidene)acetohydrazide." Acta Crystallographica Section E Structure Reports Online 66, no. 4 (2010): o927. http://dx.doi.org/10.1107/s1600536810010627.

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21

Qadeer, Ghulam, Nasim Hasan Rama, and Wen-Tong Chen. "2-(2,4-Dichlorophenylsulfanyl)acetohydrazide." Acta Crystallographica Section E Structure Reports Online 63, no. 6 (2007): o2932. http://dx.doi.org/10.1107/s1600536807022891.

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22

Guo, Huan-Mei. "N′-(1-Phenylethylidene)acetohydrazide." Acta Crystallographica Section E Structure Reports Online 63, no. 7 (2007): o3123. http://dx.doi.org/10.1107/s1600536807026748.

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23

Hanif, Muhammad, Ghulam Qadeer, Nasim Hasan Rama, Muhammad Farman, and Aleš Ružička. "2-(3-Methoxyphenyl)acetohydrazide." Acta Crystallographica Section E Structure Reports Online 63, no. 12 (2007): o4828. http://dx.doi.org/10.1107/s1600536807058990.

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24

Fun, Hoong-Kun, Ching Kheng Quah, Shridhar Malladi, Vijesh A. M., and Arun M. Isloor. "2-(4-Methylphenoxy)acetohydrazide." Acta Crystallographica Section E Structure Reports Online 67, no. 1 (2010): o165. http://dx.doi.org/10.1107/s1600536810051937.

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25

Praveen, A. S., Jerry P. Jasinski, Amanda C. Keeley, H. S. Yathirajan, and B. Narayana. "2-(2-Nitrophenyl)acetohydrazide." Acta Crystallographica Section E Structure Reports Online 68, no. 12 (2012): o3436. http://dx.doi.org/10.1107/s1600536812047381.

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26

Praveen, A. S., Jerry P. Jasinski, Shannon T. Krauss, H. S. Yathirajan, and B. Narayana. "2-(4-Methylphenyl)acetohydrazide." Acta Crystallographica Section E Structure Reports Online 68, no. 12 (2012): o3467. http://dx.doi.org/10.1107/s160053681204799x.

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27

Liu, Gang, and Jie Gao. "2-(4-Methoxyphenoxy)acetohydrazide." Acta Crystallographica Section E Structure Reports Online 68, no. 6 (2012): o1969. http://dx.doi.org/10.1107/s160053681202435x.

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The title compound, C9H12N2O3, was synthesized by the reaction of ethyl 2-(4-methoxyphenoxy)acetate with hydrazine hydrate in ethanol. In the acetohydrazide group, the N—N bond is relatively short [1.413 (2) Å], suggesting some degree of electronic delocalization in the molecule. In the crystal, molecules are linked into sheets lying parallel to the ab plane by N—H...N and N—H...O hydrogen bonds.
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28

Ahmad, Shakeel, Abdul Jabbar, Muhammad Tahir Hussain, and M. Nawaz Tahir. "2-(4-Bromophenyl)acetohydrazide." Acta Crystallographica Section E Structure Reports Online 68, no. 7 (2012): o2269. http://dx.doi.org/10.1107/s1600536812027006.

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29

Guo, Huan-mei, Li Liu, Jie Yang, and Yang-chun Liu. "N′-(4-Fluorobenzylidene)acetohydrazide." Acta Crystallographica Section E Structure Reports Online 66, no. 11 (2010): o2952. http://dx.doi.org/10.1107/s1600536810042765.

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30

Theppitak, Chatphorn, Sakchai Laksee та Kittipong Chainok. "Crystal structure and Hirshfeld surface analysis of tris(acetohydrazide-κ2 N,O)(nitrato-κO)(nitrato-κ2 O,O′)terbium(III) nitrate". Acta Crystallographica Section E Crystallographic Communications 78, № 4 (2022): 354–58. http://dx.doi.org/10.1107/s2056989022002298.

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In the title lanthanide(III) compound, [Tb(NO3)2(C2H6N2O)3]NO3, the asymmetric unit contains one Tb3+ ion, three acetohydrazide (C2H6N2O) ligands, two coordinated nitrate anions, and an isolated nitrate anion. The Tb3+ ion is in a ninefold coordinated distorted tricapped trigonal–prismatic geometry formed by three oxygen atoms and three nitrogen atoms from three different acetohydrazide ligands and three oxygen atoms from two nitrate anions. In the crystal, the complex molecules and the non-coordinated nitrate anions are assembled into a three-dimensional supramolecular architecture through ex
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31

Sukuroglu, Murat, Tijen Onkol, Fatma Kaynak Onurdağ, Gulsen Akalın, and M. Fethi Şahin. "Synthesis and in vitro Biological Activity of New 4,6-Disubstituted 3(2H)-Pyridazinone-acetohydrazide Derivatives." Zeitschrift für Naturforschung C 67, no. 5-6 (2012): 257–65. http://dx.doi.org/10.1515/znc-2012-5-604.

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New 3(2H)-pyridazinone derivatives containing a N’-benzyliden-acetohydrazide moiety at position 2 were synthesized. The structures of these newly synthesized compounds were confi rmed by IR, 1H NMR, and MS data. These compounds were tested for their antibacterial, antifungal, antimycobacterial, and cytotoxic activities. The compounds 2-[4-(4-chlorophenyl)- 6-(morpholin-4-yl)-3-oxo-(2H)-pyridazin-2-yl]-N’-(4-tert-butylbenzyliden)acetohydrazide and 2-[4-(4-chlorophenyl)-6-(morpholin-4-yl)-3-oxo-(2H)-pyridazin-2-yl]-N’-(4-chlorobenzyliden) acetohydrazide exhibited activity against both Gram-posit
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32

Šermukšnytė, Aida, Ilona Jonuškienė, Kristina Kantminienė, Zigmuntas Jonas Beresnevičius, and Ingrida Tumosienė. "2-((4-Phenyl-5-(2-(p-tolylamino)ethyl)-4H-1,2,4-triazol-3-yl)thio)-N′-(1-phenylethylidene)acetohydrazide." Molbank 2022, no. 2 (2022): M1380. http://dx.doi.org/10.3390/m1380.

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A synthesis of 2-((4-phenyl-5-(2-(p-tolylamino)ethyl)-4H-1,2,4-triazol-3-yl)thio)-N’-(1-phenylethylidene)acetohydrazide from 2-[(3-{2-[(4-methylphenyl)amino]ethyl}-4-phenyl-4,5-dihydro-1H-1,2,4-triazol-5-yl)sulfanyl]acetohydrazide and acetophenone is reported. The title compound has been tested to possess 1.5-fold higher antioxidant ability than the control, butylated hydroxytoluene, as determined by a Ferric reducing antioxidant power assay.
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33

My, Pham Thi Thanh, Chu Dinh Kinh, Thanh Thi Thu Thuy, Nguyen Ngoc Vinh, and Nguyen Thi Phuong Chi. "APPLICATION OF NMR IN THE INVESTIGATION OF DYNAMIC TAUTOMERISM OF 4(3H)-QUINAZOLINONE SYSTEM." ASEAN Journal on Science and Technology for Development 25, no. 2 (2017): 445–55. http://dx.doi.org/10.29037/ajstd.275.

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Tautomerism of 4(3H)-quinazolinone system with [(2-hydroxyphenyl)methylene]-2-(4oxoquinazolin-3(4H)-yl)acetohydrazide and N’-[(1E)-(4-hydroxy-3-methoxyphenyl)methylene]-2-(4-oxoquinazolin-3(4H)-yl)acetohydrazide as two representative compounds was investigated on the basis of 1H NMR method at coalescence with the help of line formprogramme. The dynamic parameters such as k, Ea, DG*, DH*, DS* were fully calculated with high reliability.
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34

Šermukšnytė, Aida, Kristina Kantminienė, Ilona Jonuškienė, Ingrida Tumosienė, and Vilma Petrikaitė. "The Effect of 1,2,4-Triazole-3-thiol Derivatives Bearing Hydrazone Moiety on Cancer Cell Migration and Growth of Melanoma, Breast, and Pancreatic Cancer Spheroids." Pharmaceuticals 15, no. 8 (2022): 1026. http://dx.doi.org/10.3390/ph15081026.

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4-Phenyl-3-[2-(phenylamino)ethyl]-1H-1,2,4-triazole-5(4H)-thione was used as a starting compound for the synthesis of the corresponding 1,2,4-triazol-3-ylthioacetohydrazide, which reacts with isatins and various aldehydes bearing aromatic and heterocyclic moieties provided target hydrazones. Their cytotoxicity was tested by the MTT assay against human melanoma IGR39, human triple-negative breast cancer (MDA-MB-231), and pancreatic carcinoma (Panc-1) cell lines. The selectivity of compounds towards cancer cells was also studied. In general, the synthesized compounds were more cytotoxic against
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35

Journal, Baghdad Science. "Synthesis of Some New 1,2,4-Triazoles Derived from 2-Mercaptobenzimidazole." Baghdad Science Journal 6, no. 1 (2009): 200–208. http://dx.doi.org/10.21123/bsj.6.1.200-208.

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New 1,2,4-triazole derivatives of 2-mercaptobenzimidazole (MB) are reported. Ethyl (benzimidazole-2-yl thio) acetate (1) has been prepared by condensing 2-mercaptobenzimidazole with ethylchloroacetate. The ester (1) on reacting with hydrazine hydrate gave the corresponding acetohydrazide(2)which was reacted separately with phenylisocyanate and phenylisothiocyanate, followed by ring closure in an alkaline medium giving 3-[(benzimidazole-2-yl thio) methyl]-4-phenyl-1,2,4-triazole-5-ol and 3-[(benzimidazole-2-yl thio) methyl]-4-phenyl-1,2,4-triazole-5-thiol respectively (6,7). Reaction of acetohy
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36

Nahle, Ayssar, Fadoua El-Hajjaji, Abdeslam Ghazoui, et al. "Effect of substituted methyl group by phenyl group in pyridazine ring on the corrosion inhibition of mild steel in 1.0 M HCl." Anti-Corrosion Methods and Materials 65, no. 1 (2018): 87–96. http://dx.doi.org/10.1108/acmm-03-2017-1769.

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Purpose The purpose of this paper is to study the inhibition effect of (6-phenyl-3-oxopyridazin-2-yl) acetohydrazide (GP4) on the corrosion of mild steel in acidic medium by gravimetric measurements, potentiodynamic polarization, and electrochemical impedance spectroscopy (EIS). Design/methodology/approach Weight loss measurements, potentiodynamic tests and EIS were performed during this study. Findings (6-phenyl-3-oxopyridazin-2-yl) acetohydrazide (GP4) was found to be a very efficient inhibitor for mild steel in 1.0 M HCl solution, reaching about 85 per cent with inhibitor concentration 1.0
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37

Saeed, Saeed El-Sayed, Meaad Aldubayyan, Ahmed N. Al-Hakimi, and Marwa M. Abd El-Hady. "Synthesis and Characterization of Pyridine Acetohydrazide Derivative for Antimicrobial Cotton Fabric." Materials 16, no. 13 (2023): 4885. http://dx.doi.org/10.3390/ma16134885.

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An increase in textile resistance to antimicrobial agents has posed a pressing need for the development of new antimicrobials. Therefore, the antimicrobial characteristics of thiophene and pyridine acetohydrazide derivatives have been developed as novel textile-modified complexes exhibiting antibacterial agents. Synthesis and characterization of pyridyl-thienyl acetohydrazide derivative (AHZ) using NMR (13C and 1H) and FTIR. Modification of cotton fabric (CF) with acetohydrazide (AHZ) and metal chlorides of divalent Cr, Mn, Co, Ni, Cu, and Zn and trivalent Fe, and Cr. SEM-EDX and Fourier-trans
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38

Al-Messri, Zainab, A. K. "Synthesis of Some New 1,2,4-Triazoles Derived from 2-Mercaptobenzimidazole." Baghdad Science Journal 6, no. 1 (2009): 200–208. http://dx.doi.org/10.21123/bsj.2009.6.1.200-208.

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New 1,2,4-triazole derivatives of 2-mercaptobenzimidazole (MB) are reported. Ethyl (benzimidazole-2-yl thio) acetate (1) has been prepared by condensing 2-mercaptobenzimidazole with ethylchloroacetate. The ester (1) on reacting with hydrazine hydrate gave the corresponding acetohydrazide(2)which was reacted separately with phenylisocyanate and phenylisothiocyanate, followed by ring closure in an alkaline medium giving 3-[(benzimidazole-2-yl thio) methyl]-4-phenyl-1,2,4-triazole-5-ol and 3-[(benzimidazole-2-yl thio) methyl]-4-phenyl-1,2,4-triazole-5-thiol respectively (6,7). Reaction of acetohy
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39

Şahin, Onur, Orhan Büyükgüngör, Selami Şaşmaz, Nurhan Gümrükçüoğlu, and Cihan Kantar. "2′-[Ethoxy(phenyl)methylene]acetohydrazide." Acta Crystallographica Section E Structure Reports Online 63, no. 3 (2007): o1488—o1489. http://dx.doi.org/10.1107/s1600536807008045.

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40

Lv, Lu-Ping, Tie-Ming Yu, Wen-Bo Yu, Wei-Wei Li, and Xian-Chao Hu. "N′-(3,4-Dihydroxybenzylidene)acetohydrazide monohydrate." Acta Crystallographica Section E Structure Reports Online 65, no. 8 (2009): o1897. http://dx.doi.org/10.1107/s1600536809027299.

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41

Lv, Lu-Ping, Tie-Ming Yu, Wen-Bo Yu, Wei-Wei Li, and Xian-Chao Hu. "N′-(4-Hydroxybenzylidene)acetohydrazide monohydrate." Acta Crystallographica Section E Structure Reports Online 65, no. 8 (2009): o2007. http://dx.doi.org/10.1107/s160053680902892x.

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42

Li, Wei-Wei, Tie-Ming Yu, Wen-Bo Yu, Lu-Ping Lv, and Xian-Chao Hu. "N′-[4-(Dimethylamino)benzylidene]acetohydrazide." Acta Crystallographica Section E Structure Reports Online 65, no. 9 (2009): o2197. http://dx.doi.org/10.1107/s1600536809032619.

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43

Essid, Manel, Houda Marouani, Salem S. Al-Deyab, and Mohamed Rzaigui. "N′-(2,4-Dinitrophenyl)acetohydrazide monohydrate." Acta Crystallographica Section E Structure Reports Online 69, no. 8 (2013): o1249. http://dx.doi.org/10.1107/s1600536813018916.

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44

Arif, Mubeen, Furukh Jabeen, Aamer Saeed, Irfan Zia Qureshi, and Nadia Mushtaq. "A new class of potential antidiabetic acetohydrazides: Synthesis, in vivo antidiabetic activity and molecular docking studies." Bangladesh Journal of Pharmacology 12, no. 3 (2017): 319. http://dx.doi.org/10.3329/bjp.v12i3.31428.

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<p class="Abstract">Two new pharmacologically active series of tetrazolopyridine-acetohydrazide conjugates [9 (a-n), 10 (a-n)] were synthesized by reacting a variety of suitably substituted benzaldehydes and isomeric 2-(5-(pyridin-3/4-yl)-2H-tetrazol-2-yl)acetohydrazides (7, 8). The synthesized compounds were analyzed through FTIR, <sup>1</sup>H NMR, <sup>13</sup>C NMR and elemental techniques. These acetohydrazides were screened for their in vivo antidiabetic activity and molecular docking studies. An excellent agreement was obtained as the best docked poses show
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45

Altıntop, Mehlika Dilek, Belgin Sever, Halide Edip Temel, Zafer Asım Kaplancıklı, and Ahmet Özdemir. "Design, Synthesis and In vitro COX Inhibitory Profiles of A New Series of Tetrazole-based Hydrazones." European Journal of Life Sciences 1, no. 1 (2022): 20–27. http://dx.doi.org/10.55971/ejls.1095818.

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Inhibition of cyclooxygenases (COXs), by selective and nonselective inhibitors, is a favorable approach for pharmacologic intervention in a variety of disorders such as cancer. For this purpose, a new class of tetrazole-hydrazone hybrids (1-12) was designed. A facile and efficient procedure was applied for the preparation of compounds 1-12, which were tested for their inhibitory activities towards cyclooxygenases (COXs) by means of an in vitro colorimetric method. The most potent and selective COX-1 inhibitors were determined as 2-[(1-methyl-1H-tetrazol-5-yl)thio]-N'-(4-(piperidin-1-yl)benzyli
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46

Oliveira, Ana P. A., Isabella P. Ferreira, Angel A. Recio Despaigne, et al. "Structural studies and antileishmanial activity of 2-acetylpyridine and 2-benzoylpyridine nitroimidazole-derived hydrazones." Acta Crystallographica Section C Structural Chemistry 75, no. 3 (2019): 320–28. http://dx.doi.org/10.1107/s2053229619001529.

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Three imidazole hydrazone compounds, namely 2-(4-nitro-1H-imidazol-1-yl)-N′-[1-(pyridin-2-yl)ethylidene]acetohydrazide, C12H12N6O3, (1), 2-(2-nitro-1H-imidazol-1-yl)-N′-[1-(pyridin-2-yl)ethylidene]acetohydrazide, C12H12N6O3, (2), and 2-(2-nitro-1H-imidazol-1-yl)-N′-[(phenyl)(pyridin-2-yl)methylidene]acetohydrazide, C17H14N6O3, (3), were obtained and fully characterized, including their crystal structure determinations. While all the compounds proved not to be cytotoxic to J774.A1 macrophage cells, (1) and (3) exhibited activity against Leishmania chagasi, whereas (2) was revealed to be inactiv
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47

Fathima, Anees, H. M. Vagdevi, R. Mohammed Shafeeulla, Lubna Afroz, and S. H. Shreedhara. "Design, Synthesis, Computational Docking and Biological Evaluation of Novel 4-Chloro-1,3-Benzoxazole Derivatives as Anticancer Agents." Biosciences Biotechnology Research Asia 19, no. 4 (2022): 895–915. http://dx.doi.org/10.13005/bbra/3040.

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ABSTRACT: An efficient, cost effective and ecologically safe method for the design of series of novel 2-[(4-chloro-1,3-benzoxazol-2-yl)sulfanyl]-N'-[phenylmethylidene] acetohydrazides 5(a-j) have been synthesized by fusing 2-[(4-chloro-1,3-benzoxazol-2-yl)sulfanyl] acetohydrazide with substituted aromatic aldehyde. The prepared compounds were characterized via LC-MS, IR, 1H NMR, 13C NMR and C, H, N analysis technique. All the synthesized compounds were evaluated for biological potency, which includes antimicrobial, antifungal, antioxidant and anticancer activities. The compounds 5a, 5b, 5d, 5e
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48

Singh, Shailesh Kumar, and Laxmi Tripathi. "Synthesis, Anticonvulsant Evaluation and Molecular Docking Studies of Novel Benzo[1,3]dioxol-5-yloxy-N′-(4-substituted benzylidene)acetohydrazide Derivatives." Asian Journal of Chemistry 32, no. 1 (2019): 199–204. http://dx.doi.org/10.14233/ajchem.2020.22407.

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Novel (benzo[1,3]dioxol-5-yloxy)-N′-(4-substituted benzylidene)acetohydrazide derivatives were synthesized and their anticonvulsant activity evaluated by MES and scMET seizure models. Compound 2-(benzo[d][1,3]dioxol-5-yloxy)-N′-benzylideneacetohydrazide (4a) was found to be most potent in MES seizure test and showed no neurotoxicity at the highest administered dose. All the compounds showed high docking score with γ-aminobutyric acid receptor, GABAAR-β3 homopentamer (PDB ID: 4COF). Thus, the probable mechanism of action of benzo[1,3]dioxol-5-yloxy-N′-(4-substituted benzylidene)acetohydrazide d
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49

Kapoor, D., and P. Gupta. "Synthesis and Characterization of Phenothiazine Derivatives." Pharmaceutical and Chemical Journal 3, no. 2 (2016): 57–70. https://doi.org/10.5281/zenodo.13742728.

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A series of new phenothiazine derivatives have been synthesized in which diphenylamine on treatment with sulphur give 10<em>H</em>-phenothiazinewhich on reaction with ethylchloro acetate yielded 2-(10<em>H</em>-phenothiazin-10-yl)acetate which on further treatment with hydrazine hydrate produced 2-(10<em>H</em>-phenothiazin-10-yl) acetohydrazide<strong>. </strong>Condensation of chief intermediate with various benzaldehyde derivatives afforded<em> N'</em>-(substitutedbenzylidene)-2-(10<em>H-</em>phenothiazin-10-yl) acetohydrazide. All the synthesized derivatives have been characterized by FTIR
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50

Dalal, Meinaa Jaber, and Athraa Hameed Mekky. "Synthesis, Characterization and Antioxidant Evaluation of Some Tetrazole Derivatives." Indonesian Journal of Chemistry 22, no. 6 (2022): 1596. http://dx.doi.org/10.22146/ijc.74912.

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The present study introduces the synthesis of two series of tetrazole derivatives. Firstly, monosubstituted S1 was prepared by the reaction of ethyl 4-aminobenzoate with an amount of sodium azide and triethyl orthoformate in hot glacial acetic acid. Then, ethyl 4-(1H-tetrazol-1-yl) benzoate S1 was treated with a solution of hydrazine hydrate to prepare acetohydrazide S2. After that, tetrazole derivatives S3-S4 were prepared via the reaction of acetohydrazide S2 with various aromatic aldehydes. Secondly, compound 1,5-disubstituted tetrazole S5 was prepared from the reaction of aryl isothiocyana
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