Relevant bibliographies by topics / Acetonitrile And Validation

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Acetonitrile And Validation'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Acetonitrile And Validation"

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Jeong, Min Kyu, Chan Uk Park, Min Hee Park, et al. "Validation of HPLC Methods for Ascorbic Acid and Its Derivatives in Foods." Food Engineering Progress 15, no. 1 (2011): 75–79. http://dx.doi.org/10.13050/foodengprog.2011.15.1.75.

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Analytical methods for food antioxidants including ascorbic acid, erythorbic acid, ascorbyl palmitate (AP), and ascorbyl stearate (AS), were validated using high performance liquid chromatography. Validation parameters such as linearity, limit of detection (LOD), limit of quantification (LOQ), and recovery were tested using lard and cider as food model systems. Linearity of ascorbic acid and erythorbic acid were both higher than (R2> 0.99), LOD of these compounds were 0.46 and 0.48 μg/mL, respectively and LOQ were 1.39 and 1.45 μg/mL, respectively. The recovery rates of these compounds were
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Suryawanshi, Shivraj Vithal, Omprakash G. Bhusnure, S. M. Vijayendra Swamy, Sachin B. Gholve, Padmaja S. Girm, and Mahesh J. Birajdar. "Development and Validation of a RP-UPLC Method for Determination of Linezolid in Pharmaceutical Formulation." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 654–58. http://dx.doi.org/10.22270/jddt.v9i3-s.3072.

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A simple, sensitive and accurate RP-UPLC method has been developed for the determination of Linezolid in Tablet formulation. The mix of the Linezolid was found to be 251nm in Acetonitrile: Buffer [40:60(v/v)]. The method shows high sensitivity with linearity 5 to 30μg/ml (regression r2 = 0.999). This method was tested and validated for various parameters according to ICH guidelines and USP. The Detection limit and quantitation limit were found to be 50mg ml–1 and 150 mg ml–1 in Acetonitrile: Buffer [40:60(v/v)] respectively. The results demonstrated that the procedure is accurate, precise and
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Mayuri, Bhokare* Dr. Pradyumna Ige. "Analytical Method Development and Validation of Dapagliflozin By RP-HPLC Method In Tablet Dosage Form." International Journal of Pharmaceutical Sciences 2, no. 7 (2024): 1718–28. https://doi.org/10.5281/zenodo.12801306.

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The main aim of the present research work is to develop a sensitive, precise and accurate HPLC (High-Performance Liquid Chromatography) procedure for the selective estimation of Dapagliflozin. An isocratic separation of Dapagliflozin through column used was a Inertsil ODS-3V with dimensions of 150 mm length and 4.6 mm inner diameter, packed with 5μm particle utilizing mobile phase composition of Acetonitrile and Water, with a proportion of 50% Acetonitrile and 50% water (v/v).  The detection of the analyte was processed at the maximum wavelength of 223 nm and with 1 ml/min flow of the
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Abd El-Mageed, Nasra M., Ideisan I. Abu-Abdoun, Khawla A. O. Al Shurafa, Dinesh K. Saseendran, Arwa Y. A. Binbasher, and Jalal H. Khataibeh. "Validation of Commercial Formulation of Difenoconazole Using HPLC Equipped with Dad." Global Research in Environment and Sustainability 2, no. 6 (2024): 18–30. http://dx.doi.org/10.63002/gres.26.507.

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Effective, selective, precise, and accurate liquid chromatographic analytical methods for the determination of difenoconazole fungicide in the formulation have been optimized and validated to meet the accreditation requirements, the performance characteristics of the analytical method were validated which is also one of the basic requirements of ISO Standard 17025:2017, for the rapid determination of difenoconazole by HPLC-DAD. The used method involves the extraction of the substances by sonication of the sample with acetonitrile, followed by dilution in acetonitrile, and direct injection on a
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Ogale, Shital Ashokrao* Madhav A. Shetkar. "Method Development And Validation Of Asciminib By RPHPLC." International Journal in Pharmaceutical Sciences 2, no. 6 (2024): 278–86. https://doi.org/10.5281/zenodo.11486334.

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Another methodology was set up for synchronous estimation of a Asciminib by RP-HPLC system. The chromatographic conditions were viably created for the unit of Asciminib by using Inertsil - ODS C18(250 x 4.6 mm, 5µ), stream is 1.0 ml/min, convenient stage extent was Methanol: Acetonitrile (60:40), recognizable proof wave length was 274nm.
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Mehendale, P. C., R. B. Athawale, and K. K. Singh. "DEVELOPMENT AND VALIDATION OF RAPID AND SIMPLE BIOANALYTICAL METHOD FOR DOCETAXEL WITH ONE STEP PROTEIN PRECIPITATION." INDIAN DRUGS 56, no. 07 (2019): 23–32. http://dx.doi.org/10.53879/id.56.07.11501.

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A rapid and simple bio-analytical method with one step protein precipitation and extraction using acetonitrile as extraction solvent was developed for docetaxel. The extraction efficiency was 87.81% with satisfactory separation of docetaxel and IS peaks by isocratic elution with C18 column (25 cm X 4.5 mm, 0.5μm), acetonitrile and water (53:47 % V/V) as a mobile phase at ambient temperature and flow rate of 1mL/min. Paclitaxel solution in acetonitrile (10 mcg/ mL) was used as internal standard. The calibration curve was linear over the concentration range 50 – 5000 ng/mL, regression coefficien
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Simranjeet, Singh Muskan Sood Anu Jindal* Rajmeet Singh Satvinder Kaur Jaswinder Singh Shaveta Bhardwaj. "Analytical Method Validation of Tablet Dosage Form of Lurasidone HCl." International Journal in Pharmaceutical Sciences 1, no. 11 (2023): 240–45. https://doi.org/10.5281/zenodo.10112998.

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This research is mainly focused on development of an Excellent Gradient method by reverse phase - high performance liquid chromatography (RP-HPLC) using UV Visible Detector. The main objective of method validation of Lurasidone HCl as a tablet dosage form is to validate the method as in-house method. As this tablet dosage form is not registered in any of Pharmacopeia, so the method is developed and validated for further studies. The sample is analyzed by RP-HPLC using octadecylsilane (C18) column (Inertsil LC-GC) as stationary phase with UV-Visible detector. The 'Gradient Method' is used as in
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Posyniak, Andrzej, Jan Zmudzki, Richard L. Ellis, et al. "Validation Study for the Determination of Tetracycline Residues in Animal Tissues." Journal of AOAC INTERNATIONAL 82, no. 4 (1999): 862–65. http://dx.doi.org/10.1093/jaoac/82.4.862.

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Abstract An interlaboratory study of the liquid chromatographic (LC) determination of tetracyclines—oxytetracycline (OTC), tetracycline (TTC), and chlortetracycline (CTC)—in animal tissues was conducted. Isolation was performed with oxalic buffer followed by dechelation and deproteination with oxalic acid–acetonitrile. The extract was cleaned with a styrene–divinylbenzene cartridge. LC analysis was performed with a PLRP-S column and 0.01 M oxalic acid–acetonitrile (75 + 25, v/v) as mobile phase. Participants analyzed 2 control and 10 fortified porcine muscle and kidney samples. Additionally, p
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Vázquez-Villegas, Paola T., Rocío Meza-Gordillo, María C. Luján-Hidalgo, et al. "Optimization and Validation of an Extraction Method for Endosulfan Lactone on a Solid Substrate." Processes 9, no. 2 (2021): 284. http://dx.doi.org/10.3390/pr9020284.

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Endosulfan lactone is a metabolite obtained from the biological oxidation of the insecticide endosulfan by action of the microorganisms present in the soil. This metabolite is more toxic and persistent than the parent compound. Therefore, it is extremely important to be able to determine the presence of this metabolite in the soil. However, accessible methods for extraction of endosulfan lactone in soil were not found in published literature. For this reason, the aim of this study was to evaluate two conventional methods of liquid–solid extraction for the determination of endosulfan lactone in
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Simranjeet, Singh Muskan Sood Anu Jindal* Rajmeet Singh Satvinder Kaur Jaswinder Singh Shaveta Bhardwaj. "Analytical Method Validation of Tablet Dosage Form of Lurasidone HCl." International Journal in Pharmaceutical Sciences 1, no. 11 (2023): 240–45. https://doi.org/10.5281/zenodo.10113218.

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This research is mainly focused on development of an Excellent Gradient method by reverse phase - high performance liquid chromatography (RP-HPLC) using UV Visible Detector. The main objective of method validation of Lurasidone HCl as a tablet dosage form is to validate the method as in-house method. As this tablet dosage form is not registered in any of Pharmacopeia, so the method is developed and validated for further studies. The sample is analyzed by RP-HPLC using octadecylsilane (C18) column (Inertsil LC-GC) as stationary phase with UV-Visible detector. The 'Gradient Method
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Dissertations / Theses on the topic "Acetonitrile And Validation"

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Guedes, Ana Isabel Coutinho. "Determinação post mortem de etanol em diferentes tipos de amostras biológicas: desenvolvimento e validação de uma metodologia analítica por HS-GC-FID em contexto forense." Master's thesis, 2020. http://hdl.handle.net/10316/94308.

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Dissertação de Mestrado em Medicina Legal e Ciências Forenses apresentada à Faculdade de Medicina<br>Embora o procedimento de ensaio para a quantificação do etanol seja um processo relativamente simples, segundo a literatura existem algumas dúvidas relativamente à origem do etanol determinado post mortem, uma vez que há a possibilidade de formação e eliminação post mortem desta substância, o que pode levar a uma incorreta interpretação dos resultados analíticos. Assim, como referido na literatura, é recomendado analisar para além do sangue outras matrizes biológicas. O uso de diferentes tipos
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Book chapters on the topic "Acetonitrile And Validation"

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Gopal, N. Madana, L. Siva Sanker Reddy, and R. Nageswara Rao. "METHOD DEVELOPMENT AND VALIDATION OF CILNIDIPINE IN TABLET DOSAGE FORM BY USING ULTRA VIOLET SPECTROPHOTOMETRY." In Futuristic Trends in Pharmacy & Nursing Volume 3 Book 11. Iterative International Publisher, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bgpn11p2ch5.

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A simple, quick, and accurate UV Spectroscopic method was developed to quantify celecoxib in API and tablet formulations. Celecoxib was used to treat rheumatoid arthritis and osteoarthritis. The proposed procedure was developed using acetonitrile and distilled water as the solvents in a 50:50 volume-to-volume ratio, and it was optimized using a Shimadzu UV-1800 ENG240V at a maximum wavelength of 240 nm with an absorbance of 0.558. The sensitivity, robustness, accuracy, and precision of the improved technique Degradation studies were also conducted and determined to be within the constraints. T
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G, Sowmya. "NOVEL RP - HPLC METHOD AND DEVELOPMENT AND VALIDATION FOR ESTIMATION OF PHENTERMINE USING BULK AND PHARMACEUTICAL DOSAGE FORM." In Futuristic Trends in Pharmacy & Nursing Volume 3 Book 15. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bapn15p7ch2.

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A simple and focused HPLC method is described for phentermine measurement. With a C18 column and a mobile phase made up of 40 volumes of methanol, 40 volumes of acetonitrile, and 20 volumes of water, the chromatographic separation was completed at a wavelength of 263 nm. For Phentermine, the method demonstrated linearity in the 50–150 µg/ml range (r2 = 0.990), and the drug amounts found using this suggested method nearly matched the label claim. It is clear from the previously described testing results and parameters that this newly developed approach for phentermine estimate is simple, accura
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Mohammed, Jahasultana, and Buchi N. Nalluri. "Development and Validation of RP-HPLC-PDA Method for the Estimation of Fluoxetine Hydrochloride in Bulk, Mouth Dissolving Films and in Dissolution Samples." In Current Trends in Drug Discovery, Development and Delivery (CTD4-2022). Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/9781837671090-00283.

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Selective serotonin reuptake inhibitor, fluoxetine hydrochloride (FLX) is a drug of choice for treating depression, obsessive-compulsive disorder (OCD), bulimia nervosa, etc. Even though FLX dosage forms such as tablets, capsules, oral solutions, and syrups are already available commercially, there is a considerable need for developing modified or immediate-release formulations with a quick onset of action and high bioavailability. The goal of this research is to provide a quick, practical, and cost-effective RP-HPLC-PDA approach for determining Fluoxetine hydrochloride (FLX) in bulk, mouth di
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K, Shah Chandra, Dr Dedania Zarna, Dr Dedania Ronak, and Dr Jain Vineet C. "ANALYTICAL QBD APPROACH TO HPLC METHOD DEVELOPMENT AND VALIDATION FOR PREGABALIN." In Futuristic Trends in Pharmacy & Nursing Volume 3 Book 19. Iterative International Publisher, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bgpn19p1ch6.

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Analytical QbD helps to provideanalytical life cycle management by systemic method development and maintenance. An efficient CCD - Central Composite Design was developed at 23 factorial designs; mobile phase composition and pH kept as two different factors at law(-1), medium(0) and high(+1) at three levels for RP-HPLC method. The response to be evaluated being retention time, peak asymmetry and theoretical plates. The chromatographic separation conditions were optimized with the Design Expert Software version10.0.1.0, i.e. Inertsil ODS column C18 (250×4.6mm, 5.0µm), mobile phase used werephosp
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D. China Babu, Dr, G. Sai Sri Harsha, G. Venkateswarlu, M. Alagusundaram, Shailendra Singh Narwariya, and SK Aleesha. "STABILITY INDICATING BIO-ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE QUANTIFICATION OF APALUTAMIDE - APALUTAMIDE D3 BY USING ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY IN HUMAN PLASMA." In Futuristic Trends in Pharmacy & Nursing Volume 3 Book 4. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bipn4p1ch3.

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A simple, convenient, specific,precise and highly conventional stability indicating ultra performance liquid chromatographic diode array method was developed for the quantification of Apalutamide in human plasma. The phenomenex Luna (100x4.6x5µ) column was used for apalutamide separation and mobile phase was composed with 5 mM ammonium fumarate and acetonitrile in the ratio of 15:85 v/v and buffer pH 3.5 was adjusted with glacial acetic acid and detected at 345 nm. The Apalutamide D3 used as internal standard and K2 EDTA used as coagulant.The liquid liquid extraction process used for extractio
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Jain, Paras, N. V. D. Prasad Ketha, and Buchi N. Nalluri. "A High-Performance Liquid Chromatographic Method for Dissolution Testing of Lurasidone Tablets." In Current Trends in Drug Discovery, Development and Delivery (CTD4-2022). Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/9781837671090-00296.

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A simple, rapid, selective, and reproducible HPLC method for Lurasidone Hydrochloride tablet release estimation has been developed and validated. An Agilent, X-Bridge column C18,150*4.6 mm, 3.5m was used to produce a symmetrical peak form at a regulated column temperature of 25°C with a flow rate of 1.5 mL/min, a mobile phase component of A and B in the ratio of 30:70, a run time of 14 minutes, and an isocratic elution. Mobile phase A is 0.2% ammonia in water with a pH of 8.5, and mobile phase B is 98:2 acetonitrile and water. At 232 nm, 25 μL sample solutions were injected. A two-stage acid-b
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Rajasekhar, K., Ch Gangu Naidu, Ch Naga Sesha Sai Pavan Kumar, K. Varaprasada Rao, and Y. Srinivasa Rao. "Development and Validation of A RP-HPLC Method for the Simultaneous Determination of Twenty Related Substances of Sulfamethoxazole and Trimethoprim in Injection Dosage Form." In Current Trends in Drug Discovery, Development and Delivery (CTD4-2022). Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/9781837671090-00246.

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A simple, robust and for the quantification of experimentally 20 related impurities of sulfamethoxazole (SM) and trimethoprim (TM) in liquid pharmaceutical dosage form, a novel RP-HPLC method was developed. Utilizing gradient elution on a Kromasil 100-5-C18; 5.0 m, (4.0x250) mm, column, chromatographic separation was accomplished. Solvent A (solution of 0.08% orthophosphoric acid in water) and Solvent B (mixture of acetonitrile and methanol, 80:20 v/v), given at a flow rate of 0.8 ml/min, respectively, make up the mobile phase. Using a photodiode array (PDA) detector, the analytes were identif
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Conference papers on the topic "Acetonitrile And Validation"

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Atia, Fathy Atia Mohamed, Ahmad Ali Ahmadi, and Mohammed AlSafran. "Method Validation of Drug Quantification Poster." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0058.

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A lowest detection limit with straight linearity was obtained by developing a method to analyze Phenacetin (Phe) in both aqueous and organic extraction by using Liquid chromatography Triple Quoadrpole mass with electrospray ionization (LCMSMS/ESI). The validation of the developed method was carried out according to ICH Harmonized Tripartite guideline. Validation criteria obtained were; the method detection limit MDL is 0.089 ng/ml, method quantification limit MQL is 0.19 ng/ml while the calibration curve linear from 0.1 to 1000 ng/mL with correlation coefficient R2 is 0.9994, Accuracy and prec
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