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Dissertations / Theses on the topic 'Acetyl derivatives'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

Gregar, Travis Quinton. "Synthesis and structural characterization of amide-linked derivatives of N-acetyl neuraminic acid." Diss., The University of Arizona, 2001. http://hdl.handle.net/10150/279827.

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Amide linked carbohydrates represent a tremendously different type of compound. Sugars have traditionally been linked together as either N or O linked via the anomeric carbon to make larger compounds, i.e. Sialyl Lewis X. This linkage leads to great instability under acidic and biological conditions. N-Acetyl neuraminic acid is a naturally occurring delta peptide. Colominic acid is the naturally occurring O linked polymer of N-acetyl neuraminic acid. This polymer has been found to possess a helical structure starting at the hexamer length. Changing from an O linkage to an amide linkage provid

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2

Drieman, Johannes Cornelis. "Drug targeting to the kidney N-acetyl-L-[gamma]-glutamyl derivatives as kidney-selective prodrugs /." Maastricht : Maastricht : Datawyse ; University Library, Maastricht University [Host], 1989. http://arno.unimaas.nl/show.cgi?fid=6187.

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3

Cox, Glen Adam. "Towards the Synthesis of N-Acetyl-2-amino-2-deoxy-D-mannopyranose uronic acid (D-ManNAcA) and Derivatives." Youngstown State University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1217344144.

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4

Buabeng, Emmnauel Ramsey. "Towards the Synthesis of Novel Glycomimetics of N-Acetyl-2-amino-2-deoxy-D-mannopyranose uronic acid (D-ManNAcA) and Derivatives." Youngstown State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1471478050.

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5

Chaudhry, Humayun Iqbal. "An evaluation of the performance and mechanistic action of the costabiliser N-phenyl-3-acetyl pyrrolidine-2,4-dione and its derivatives in poly(vinyl chloride)." Thesis, Manchester Metropolitan University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311051.

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6

Mann, S. E. "New reactions of cyclic oxygen, nitrogen and sulfur acetal derivatives." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1317775/.

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This thesis describes the development of new reactions of cyclic oxygen, nitrogen and sulfur acetal derivatives and their applications in a diverse range of synthetic organic and organometallic chemistry. Detailed herein are advances in three main areas of acetal chemistry, namely: studies towards a new methodology for the synthesis of medium ring heterocycles; the use of thioacetals as directing groups for the palladium-mediated oxidation of olefins; and multi-component reactions for the synthesis of drug-like heterocyclic compounds. A brief overview of the chemistry of cyclic acetal derivati

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7

Duarte, Claudimar Junker 1984. "Análise conformacional de alguns ésteres metílicos de aminoácidos e seus N-acetil-derivados." [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/249202.

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Orientador: Roberto Rittner Neto<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Química<br>Made available in DSpace on 2018-08-27T10:22:25Z (GMT). No. of bitstreams: 1 Duarte_ClaudimarJunker_D.pdf: 13121295 bytes, checksum: 3401d9f1581d3385c70c6c859f152c76 (MD5) Previous issue date: 2015<br>Resumo: Neste trabalho, o equilíbrio conformacional de alguns ésteres metílicos de aminoácidos não acetilados (L-Serina, L-Treonina e L-Triptofano) e N-acetilados (Glicina, L-Alanina, L-Serina, L-Treonina e L-Triptofano) foi avaliado através de cálculos teóricos e técnicas experimen

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8

Appleton, Martin Lee. "Part 1, NMR assignments of acetyl and trityl groups in derivatized carbohydrates via proton-carbon long-range couplings ; Part 2, the conformational equilibria of 1,2,3,4-tetra-O?-acetyl-?-D-ribopyranose and 1,2,3,4-tetra-O?-acetyl-?-D-xylopyranose /." The Ohio State University, 1988. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487591658173866.

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9

Sardessai, R. S. "Inositol 1,3-acetals as versatile intermediates for the synthesis of cyclitol derivatives." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2017. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/5877.

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10

Wilson, David William Joseph. "Synthesis and anti-tumour activity of some new derivatives of flavone-8-acetic acid." Thesis, University of St Andrews, 1995. http://hdl.handle.net/10023/15461.

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A robust six-step synthesis of substituted flavone-8-acetic acid sodium salts has been developed and optimised to allow preparation of a wide variety of products for testing as anti-tumour agents. The condensation and cyclisation steps have been combined in an efficient one-pot procedure and efficient procedures for subsequent oxidative cleavage of an allyl group and salt formation have been developed. Using this method a total of 18 derivatives bearing substituents on the 2-phenyl ring have been prepared. Based on encouraging activity from methoxy substituted compounds, attention has been con

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11

Milroy, Lech-Gustav. "Molecular diversity in drug discovery : design synthesis and biological evaluation of novel natural product derived bicyclic acetal derivatives." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612280.

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12

Conley, Matthew. "Supercritical Water Gasification of Two-Carbon Carboxylic Acid Derivatives." Ohio University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1542202432022198.

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13

Sutton, Peter William. "Ketene cycloadditions to cyclohexa-3,5-diene-cis-1,2-diol acetals : preparation of polyhydroxylated cyclohexane derivatives." Thesis, University of Exeter, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294477.

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14

Nieto-Jacobo, Maria F., Johanna M. Steyaert, Fatima B. Salazar-Badillo, et al. "Environmental Growth Conditions of Trichoderma spp. Affects Indole Acetic Acid Derivatives, Volatile Organic Compounds, and Plant Growth Promotion." FRONTIERS MEDIA SA, 2017. http://hdl.handle.net/10150/622867.

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Trichoderma species are soil-borne filamentous fungi widely utilized for their many plant health benefits, such as conferring improved growth, disease resistance and abiotic stress tolerance to their hosts. Many Trichoderma species are able to produce the auxin phytohormone indole-3-acetic acid (IAA), and its production has been suggested to promote root growth. Here we show that the production of IAA is strain dependent and diverse external stimuli are associated with its production. In in vitro assays, Arabidopsis primary root length was negatively affected by the interaction with some Trich

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15

Langham, Jennifer. "Effects of aspirin and its derivatives in combination with electroporation for drug delivery in cultured cells." [Tampa, Fla.] : University of South Florida, 2004. http://purl.fcla.edu/fcla/etd/SFE0000614.

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16

Namazi, Hassan. "Novel regioselective syntheses of carbohydrate clusters and ß-cyclodextrin derivatives and studies of the reactions of dialkylstannylene acetals of carbohydrate-derived cis-1,2-diols." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq24757.pdf.

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17

Bukataru, J. S. "The study of the derivatives of 2-benzamide-2-(2-oxoindolin-3-iliden) acetic acid on the antihypoxic activity under the conditions of hypobaric hypoxia." Thesis, Буковинський державний медичний університет, 2014. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/7915.

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18

Bukataru, Yu S. "Influence of the derivative of 2-benzamido-2-(2-oxoindolin-3-iliden) acetic acid on the activity of free-radical processes in traumatic brain injury." Thesis, БДМУ, 2017. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/17345.

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19

Burns, Kristi Lee. "An exploration of biochemistry including biotechnology, structural characterization, drug design, and chromatographic analyses." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2006. http://hdl.handle.net/1853/29593.

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Thesis (Ph. D.)--Chemistry and Biochemistry, Georgia Institute of Technology, 2007.<br>Committee Chair: Sheldon W. May ; Committee Members: Donald F. Doyle, Leslie T. Gelbaum, Stanley H. Pollock, and James Powers. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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20

YU, CHUNG FEN, and 鍾芬裕. "Synthesis of Novel N-Acetyl-N-hydroxy amino Thymidine Derivatives." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/61563394564179423330.

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碩士<br>朝陽科技大學<br>應用化學系碩士班<br>89<br>Abstract In this thesis we discuss on the synthesis of compound 42 ,which contains bicyclic deoxynucleose. Two other new compounds, 20 and 21,were obtained during the synthesis process. By applying Mitsunobu method , we have synthesized compound 43. The acetyl group of compound 43 was then hydrolyzed and became compound 42. By cooperating with pharmacologists , we are now evaluating the biological activities of these compounds. We hope that some useful compounds could be su

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21

彭明玲. "Synthesis of acetyl derivatives of anthraquinone by various methods were examined." Thesis, 1987. http://ndltd.ncl.edu.tw/handle/72690481756278471309.

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22

Shieh, Chung-Yee, and 謝忠益. "The study and synthesis of N-acetyl-leucyl-leucyl-norleucinal derivatives." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/y5u4jc.

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碩士<br>國立成功大學<br>臨床藥學研究所<br>90<br>英文摘要 P-glycoprotein (Pgp), the multidrug resistance gene (mdr1) product, reduces the intracellular accumulation of a variety of drugs by pumping drugs out of membranes. Studies have demonstrated that hydrophobic tripeptides N-acetyl- leucyl- leucyl-norleucinal (ALLN), N-acetyl- leucyl-leucyl-methiminal (ALLM) and N-acetyl-leucyl-leucyl-arginal (leupeptin) are Pgp substrates/inhibitors. We would like to synthesize a series of tripeptides (N-acetyl-leu-leu-X ) and to study the interaction between the tripeptides and Pgp. We employ liquid-phase peptide synthesis

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23

Fidalgo, Lara Gião. "Sulfonate and acetyl derivatives of the vasopressin antagonist tolvaptan: reactivity towards DNA and 2’-deoxynucleosides." Master's thesis, 2015. http://hdl.handle.net/10362/18454.

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Tolvaptan is an orally effective nonpeptide arginine vasopressin (AVP) V2-receptor antagonist, used in the treatment of clinically significant euvolemic and hypervolemic hyponatremia. Nonetheless, Tolvaptan was reported to be associated with a high risk of liver injury, prompting the U. S. Food and Drug Administration (FDA) to issue a black box label warning. Whereas the mechanisms of tolvaptan-induced liver injury remain to be elucidated, preliminary results obtained in cytochrome P450 (CYP)-deficient liver cell lines have shown evidence of tolvaptaninduced DNA damage without the need for Pha

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24

Chan, Chien-Ching, and 詹前慶. "Substituent and Solvent Effects on Keto-Enol Tautomerism of Acetyl, Carbamoyl Derivatives, and Their Radical Cations." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/41560203078684144988.

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碩士<br>國立清華大學<br>化學系<br>87<br>Abstract The results of DFT study of the substituent effects on molecular structures, relative stabilities, and mechanisms of intramolecular proton transfer in isolated acetyl and carbamoyl drivatives, for both neutral molecules and their radical cations, are reported. The reaction in the presence of one and two water molecules is also investigated. Furthermore, the effect of bulk water is considered for the system with two water molecules using the PCM continuum models. All of geometries of the local minima and transition states were optimized without

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25

Wu, Cheng-Cang, and 吳承倉. "Theoretical studies on the keto enol intramolecular tautomerism of some acetyl derivatives ,CH3COR,(R=H ,F,Cl,OH,CN,NC,BH2,NH2, CH3)." Thesis, 1993. http://ndltd.ncl.edu.tw/handle/37138703972617407809.

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26

Liu, Fu-Chien, and 劉福千. "Efficient 1H NMR method for quality analysis of the enzyme hydrolyzed products of chitin and using 1H-NMR to study the dynamic behavior of N-acetyl-D-glucosamine derivatives." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/74267706736676243129.

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碩士<br>國立成功大學<br>化學系碩博士班<br>95<br>Chitinase (EC 3.2.1.14) hydrolyzes ��-1,4-glycosidic linkages of chitin .The most widely used method for the analysis of the chitinase-catalyzed hydrolysis products of ��- and ��-chitin is HPLC. However, this method associated with disadvantages such as the enzyme must be deactivated and filtered by dialytic membrane before going to separate by HPLC analysis and also needed the calibration curves to determine quantitatively the contents of chitin hydrolysis products. In the present study, a 1H NMR method was developed to analyze the chitinase-catalyzed chitin h

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27

Ribeiro, Morais Goreti, Inês P. F. Oliveira, Andrew J. Humphrey, and Robert A. Falconer. "Identification of an acetyl disulfide derivative in the synthesis of thiosialosides." 2009. http://hdl.handle.net/10454/4614.

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No<br>The first report of the formation of an acetyl disulfide sialoside during the synthesis of thioglycosides is described. This compound is a by-product in the synthesis of the 2-thioacetyl sialoside commonly used in thioglycoside preparation. Our investigations into the identification of this novel disulfide are described.

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28

Tafazoli, Shahrzad. "Prooxidant activity and cellular effects of indole-3-acetic acid derivative radicals." 2004. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=81154&T=F.

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29

Ting, Chen Chien, and 陳建廷. "Synthesis and Biological activity of 2-(2'-Fluorophenyl)-4-quinolone-8-acetic acid Derivatives." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/83331142549866230516.

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碩士<br>中國醫藥大學<br>藥物化學研究所<br>93<br>Abstract In the present study, 2-(2'-fluorophenyl)-4-quinolone-8-acetic acid was synthesized and cytotoxicity was evaluated. The result showed significant activity. Encouraged by the initial result, 2-(2'-fluorophenyl) -4-quinolone-8-acetic acid derivatives were synthesized。 Reaction of substituted acetophenones 1-6 with diethylcarbonate yielded the substituted ethyl benzoylacetates 8-13. Esterification of 2-nitrophenylacetic acid 14 with methanol got the compound 15. Then, reduction of comupound 15 got the compound 16 that reacted with compounds 8-13 via cyc

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30

Nien, Chih-Ying, and 粘知盈. "Synthesis of Bis-(di-acetic acid) and Bis-malonic Acid Sodium Salt Derivatives as Potential Metal Chelators." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/58828990691580343400.

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碩士<br>國防醫學院<br>藥學研究所<br>94<br>Metal ions are essential cofactors for many functional metalloproteins. Thus, removel of metal ions may be a useful way to alter the function of metalloproteins. Metal ions chelators are a class of chemical agents that are able not only to bind and remove metal ions from the body, even from metalloproteins. In the past decade, many new viable utilities for metal ions chelators have been reported. This includes the use of iron chelators as antiviral, antiproliferative, antifibrotic, and photoprotective. EDTA has been shown to be a powerful chelators, which chelates

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31

Yeh, Sue-Min, and 葉素敏. "Chelation Assisied Reactions of Acetals,Ketals and Orthoesters with Grignard Reagents-Selective syntheses of myo-Inositol Derivatives." Thesis, 1997. http://ndltd.ncl.edu.tw/handle/40585062219964316124.

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博士<br>國立臺灣大學<br>化學系<br>85<br>Chelation assisted reactions of acetals,ketals and orthoesters with Grignard reagents afford the corresponding ring-opening products in highly regioselectivity. Contiguous diols can thus be differentiated easily by theses procedures. Reactions of orthoesters of myo-inositol with Grignard reagents yield regio- and stereoselective the corresponding products having a free group at C-1. The regioselectivity is rationalized owning to the presence of 2-methoxy

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32

Hsien, Wu Shu, та 吳姝嫻. "Part 1：The synthesis of α-hydroxyl acetic acid derivativesPart 2：The synthesis of 6-ethoxycarbonyl-5H-azuleno [1,8a,8-c,d]pyridazine derivatives". Thesis, 2001. http://ndltd.ncl.edu.tw/handle/76548925108250377053.

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碩士<br>中原大學<br>化學研究所<br>89<br>Abstract This thesis includes two parts. The first part discusses the synthesis of α-hydroxyl acetic acid derivatives: The reaction of methyl benzoylformate with isopropylmagnesium chloride at 0℃ afforded a mixture of methyl 2-hydroxy-3-methyl-2-phenylburate and methyl benzoylformate, which can not be separated chromatographically. The methyl 2-hydroxy-3-methyl-2-phenylburate was finally purified by addition of primary amine to the reaction mixture to remove methyl benzoylformate. The methyl 2-hydroxy-3-methyl -2-phenylburate was then acidified to give me

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