Relevant bibliographies by topics / Acetylation α-Tubulin

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Academic literature on the topic 'Acetylation α-Tubulin'

Author: Grafiati
Published: 22 June 2024
Last updated: 31 July 2025

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Journal articles on the topic "Acetylation α-Tubulin"

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Chu, Chih-Wen, Fajian Hou, Junmei Zhang та ін. "A novel acetylation of β-tubulin by San modulates microtubule polymerization via down-regulating tubulin incorporation". Molecular Biology of the Cell 22, № 4 (2011): 448–56. http://dx.doi.org/10.1091/mbc.e10-03-0203.

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Dynamic instability is a critical property of microtubules (MTs). By regulating the rate of tubulin polymerization and depolymerization, cells organize the MT cytoskeleton to accommodate their specific functions. Among many processes, posttranslational modifications of tubulin are implicated in regulating MT functions. Here we report a novel tubulin acetylation catalyzed by acetyltransferase San at lysine 252 (K252) of β-tubulin. This acetylation, which is also detected in vivo, is added to soluble tubulin heterodimers but not tubulins in MTs. The acetylation-mimicking K252A/Q mutants were inc
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Calogero, Alessandra Maria, Milo Jarno Basellini, Huseyin Berkcan Isilgan та ін. "Acetylated α-Tubulin and α-Synuclein: Physiological Interplay and Contribution to α-Synuclein Oligomerization". International Journal of Molecular Sciences 24, № 15 (2023): 12287. http://dx.doi.org/10.3390/ijms241512287.

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Emerging evidence supports that altered α-tubulin acetylation occurs in Parkinson’s disease (PD), a neurodegenerative disorder characterized by the deposition of α-synuclein fibrillary aggregates within Lewy bodies and nigrostriatal neuron degeneration. Nevertheless, studies addressing the interplay between α-tubulin acetylation and α-synuclein are lacking. Here, we investigated the relationship between α-synuclein and microtubules in primary midbrain murine neurons and the substantia nigra of post-mortem human brains. Taking advantage of immunofluorescence and Proximity Ligation Assay (PLA),
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Yang, Wulin, Xiangxiang Guo, Shermaine Thein та ін. "Regulation of adipogenesis by cytoskeleton remodelling is facilitated by acetyltransferase MEC-17-dependent acetylation of α-tubulin". Biochemical Journal 449, № 3 (2013): 605–12. http://dx.doi.org/10.1042/bj20121121.

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Cytoskeleton remodelling is a prerequisite step for the morphological transition from preadipocytes to mature adipocytes. Although microtubules play a pivotal role in organizing cellular structure, regulation of microtubule dynamics during adipogenesis remains unclear. In the present paper we show that acetylation of α-tubulin is up-regulated during adipogenesis, and adipocyte development is dependent on α-tubulin acetylation, as expression of an acetylation-resistant α-tubulin mutant significantly inhibits adipogenesis. Moreover, acetylation of α-tubulin is under the control of the acetyltran
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Carmona, Bruno, H. Susana Marinho, Catarina Lopes Matos, Sofia Nolasco, and Helena Soares. "Tubulin Post-Translational Modifications: The Elusive Roles of Acetylation." Biology 12, no. 4 (2023): 561. http://dx.doi.org/10.3390/biology12040561.

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Microtubules (MTs), dynamic polymers of α/β-tubulin heterodimers found in all eukaryotes, are involved in cytoplasm spatial organization, intracellular transport, cell polarity, migration and division, and in cilia biology. MTs functional diversity depends on the differential expression of distinct tubulin isotypes and is amplified by a vast number of different post-translational modifications (PTMs). The addition/removal of PTMs to α- or β-tubulins is catalyzed by specific enzymes and allows combinatory patterns largely enriching the distinct biochemical and biophysical properties of MTs, cre
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Antel, Matthew, Taylor Simao, Muhammed Burak Bener, and Mayu Inaba. "Drosophila CG17003/leaky (lky) is required for microtubule acetylation in early germ cells in Drosophila ovary." PLOS ONE 17, no. 11 (2022): e0276704. http://dx.doi.org/10.1371/journal.pone.0276704.

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Microtubule acetylation is found in populations of stable, long-lived microtubules, occurring on the conserved lysine 40 (K40) residue of α-tubulin by α-tubulin acetyltransferases (αTATs). α-tubulin K40 acetylation has been shown to stabilize microtubules via enhancing microtubule resilience against mechanical stress. Here we show that a previously uncharacterized αTAT, Drosophila CG17003/leaky (lky), is required for α-tubulin K40 acetylation in early germ cells in Drosophila ovary. We found that loss of lky resulted in a progressive egg chamber fusion phenotype accompanied with mislocalizatio
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Niu, Xiaoxiao, Chuan-Xi Mao, Shan Wang та ін. "α-Tubulin acetylation at lysine 40 regulates dendritic arborization and larval locomotion by promoting microtubule stability in Drosophila". PLOS ONE 18, № 2 (2023): e0280573. http://dx.doi.org/10.1371/journal.pone.0280573.

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Posttranslational modification of tubulin increases the dynamic complexity and functional diversity of microtubules. Acetylation of α-tubulin at Lys-40 is a highly conserved posttranslational modification that has been shown to improve the flexibility and resilience of microtubules. Here we studied the in vivo functions of α-tubulin acetylation by knocking-out Atat, the Drosophila α-tubulin acetyltransferase, and by mutating Lys-40 to Arg in α1-tubulin. We found a reduction in the dendritic arborization of larval class I dendritic arborization (da) neurons in both mutants. The dendritic develo
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Fernández-Barrera, Jaime, Miguel Bernabé-Rubio, Javier Casares-Arias та ін. "The actin-MRTF-SRF transcriptional circuit controls tubulin acetylation via α-TAT1 gene expression". Journal of Cell Biology 217, № 3 (2018): 929–44. http://dx.doi.org/10.1083/jcb.201702157.

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The role of formins in microtubules is not well understood. In this study, we have investigated the mechanism by which INF2, a formin mutated in degenerative renal and neurological hereditary disorders, controls microtubule acetylation. We found that silencing of INF2 in epithelial RPE-1 cells produced a dramatic drop in tubulin acetylation, increased the G-actin/F-actin ratio, and impaired myocardin-related transcription factor (MRTF)/serum response factor (SRF)–dependent transcription, which is known to be repressed by increased levels of G-actin. The effect on tubulin acetylation was caused
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Even, Aviel, Giovanni Morelli, Loïc Broix, et al. "ATAT1-enriched vesicles promote microtubule acetylation via axonal transport." Science Advances 5, no. 12 (2019): eaax2705. http://dx.doi.org/10.1126/sciadv.aax2705.

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Microtubules are polymerized dimers of α- and β-tubulin that underlie a broad range of cellular activities. Acetylation of α-tubulin by the acetyltransferase ATAT1 modulates microtubule dynamics and functions in neurons. However, it remains unclear how this enzyme acetylates microtubules over long distances in axons. Here, we show that loss of ATAT1 impairs axonal transport in neurons in vivo, and cell-free motility assays confirm a requirement of α-tubulin acetylation for proper bidirectional vesicular transport. Moreover, we demonstrate that the main cellular pool of ATAT1 is transported at
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Elesinnla, Abosede, Rehana Khatoon, Nicholas Kleinert, Junfang Wu, Jaylyn Waddell та Tibor Kristian. "Ethanol Administration in Mice Leads to Sex-Specific Changes in the Acetylation of α-Tubulin in the Cerebellum". Brain Sciences 15, № 4 (2025): 326. https://doi.org/10.3390/brainsci15040326.

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Background: Acetylation of α-tubulin is an important post-translational modification that helps maintain microtubules’ stability and dynamics, including axonal transport, cell signaling, and overall neuronal integrity. This study investigates sex-based differences in alcohol-induced acetylation of α-tubulin in mouse cerebellum. Methods: Adult, 3-month-old male and female C57BL/6 mice were administered 20% ethanol intraperitoneally. The cerebellum was dissected at 30 min, 1 h, 2 h, and 4 h post-injection. Expression levels of cerebellar acetylation of α-tubulin and enzymes mediating acetylation
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Olenieva, V. D., D. I. Lytvyn, A. I. Yemets, and Ya B. Blume. "Expression profiling of kinesins, involved in the development of autophagy in Arabidopsis thaliana, and the role of tubulin acetylation in the interaction of Atg8 protein with microtubules." Faktori eksperimental'noi evolucii organizmiv 22 (September 9, 2018): 162–68. http://dx.doi.org/10.7124/feeo.v22.942.

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Aim. To investigate the interrelation between changes in the expression levels of kinesin genes that are potentially involved in the development of stress-induced autophagy in Arabidopsis thaliana by means of microtubules, and the structural biology analysis of the role of α-tubulin acetylation in the regulation of interaction of α-tubulin with Atg8. Methods. The simulation of the influence of abiotic stresses. PCR analysis of changes in expression levels of kinesin genes. The molecular dynamics simulations of α-tubulin and Atg8 complexes were performed using the GROMACS 4.5.5 program. Results
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Dissertations / Theses on the topic "Acetylation α-Tubulin"

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Francis, Sarah Louise. "The role of α-tubulin acetylation in the regulation of murine sperm motility". Thesis, Durham University, 2019. http://etheses.dur.ac.uk/12953/.

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Sperm motility is a vital function required for fertility and is a consequence of interactions between components of the axoneme in the sperm flagellum. Microtubules, made up of α and β-tubulin, are a central component of the axoneme and undergo various post translational modifications. One such modification is the acetylation of the lysine 40 residue of α-tubulin which is carried out by α-tubulin acetyltransferase (α-TAT1), and is deacetylated by the activities of histone deacetylase 6 (HDAC6) and SIRT2. Recently, research has implicated α-tubulin acetylation in the regulation of sperm motili
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Chatterjee, Shruti. "Restoration of autophagic flux in vascular endothelial cells to prevent atherosclerosis lesion development." Electronic Thesis or Diss., Université Paris Cité, 2020. http://www.theses.fr/2020UNIP5149.

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Les lésions athéroscléreuses se développent préférentiellement dans les zones de bifurcation et au niveau des arcades artérielles, où les cellules endothéliales sont exposées à un écoulement turbulent, et par conséquent à une faible contrainte de cisaillement. Les cellules endothéliales exposées à une faible contrainte de cisaillement expriment des marqueurs pro-inflammatoires, libèrent des cytokines, et présentent, en plus d'un phénotype pro-inflammatoire, un phénotype pro-sénescent. Notre équipe a précédemment démontré qu'un processus autophagique défectueux est le lien entre l'existence d'u
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Wu, Yu-Ting, та 吳雨亭. "Increase in Mitochondrial Mass and α-tubulin Acetylation of Human Cells in Response to Oxidative Stress". Thesis, 2003. http://ndltd.ncl.edu.tw/handle/86269180229037111337.

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碩士<br>中山醫學大學<br>生物化學研究所<br>91<br>Recent results suggest that both the mitochondrial mass and the mitochondrial DNA (mtDNA) copy number are increased during in vivo aging process and in vitro cellular replicative senescence. During the aging process, oxidative damage and mutation of mtDNA are accumulated and they contribute to the decline in mitochondrial respiratory function. Moreover, the increase in mitochondrial mass and mtDNA copy number in aged tissues was suggested as a result of a feedback mechanism to compensate for the impaired mitochondrial function with age. In a previous study, non
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Bílková, Karolína. "Vliv suplementace karotenoidy a oxidačního stresu na morfologii, kvalitu spermií a spermatogenezi u zebřičky pestré." Master's thesis, 2018. http://www.nusl.cz/ntk/nusl-380194.

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The phenotype-linked fertility hypothesis predicts that both, male carotenoid-based sexual ornamentation and their spermatozoa are phenotypically plastic and may be co-affected by the environment. One of the factors affecting their phenotype may be oxidative stress and the ability of organism to eliminate its effect. Oxidative stress may reduce sperm quality because sperm lack the ability to repair DNA, but it can also affect spermatogenesis itself. However, some substances may function as antioxidants, and thus eliminate effect of reactive oxygen species (oxidative stress) in the body. In thi
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Palma, Andreia Filipa Martins. "The role of SIRT2 in alpha-tubulin, Tau and alpha-synuclein post-translational modifications in parkinson's disease." Master's thesis, 2015. http://hdl.handle.net/10316/30668.

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Trabalho final de mestrado integrado em Medicina (Biologia Molecular), apresentado à Faculdade de Medicina da Universidade de Coimbra.<br>Sporadic Parkinson’s disease (sPD) is characterized by mitochondrial dysfunction and the accumulation of protein aggregates in a specific group of neurons. It has already been demonstrated by our group that microtubule (MT) - dependent dynamics disruption due to mitochondrial dysfunction have a major role in sPD etiopathogenesis. Given that the MT network is disrupted in sPD cells and that microtubule associated proteins (MAPs) allow MT stabilization we aim
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Conference papers on the topic "Acetylation α-Tubulin"

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Boggs, Amanda E., Michele I. Vitolo, Rebecca A. Bettes, Jana Slovic, Monica S. Charpentier та Stuart S. Martin. "Abstract 2627: Acetylation of α-tubulin contributes to microtentacle formation and re-attachment in suspended breast tumor cells." У Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-2627.

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Chang, Jang-Yang, та Yun-Ching Cheng. "Abstract 4379: MPT0B292 enhances acetylation of α-tubulin through up-regulation of acetyltransferase gene, MEC-17 and exhibits potent anti-tumor, anti-angiogenesis and anti-metastatic effects in vitro and in vivo". У Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-4379.

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