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Dissertations / Theses on the topic 'Acid and bile tolerance'

Author: Grafiati

Published: 10 January 2023

Last updated: 31 July 2025

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1

Chou, Lan-Szu. "Isolation and Biochemical Characterization of Acid- and Bile- Tolerant Strains of Lactobacillus Acidophilus and Bifidobacterium Bifidum." DigitalCommons@USU, 1997. https://digitalcommons.usu.edu/etd/5427.

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Lactic acid bacteria have been reported to be used as a health adjunct in food for u many years. However, these health benefits have not been proven. and how these bacteria pass through the digestion process and remain viable in the human intestinal tract is still not clear. The aim of this work was to isolate mutants from Lactobacillus acidophilus or Bifidobacterium bifidum that could tolerate the conditions of the digestion process (low pH and bile conduction) and to characterize these isolated mutants. Acid- and bile-tolerant mutants of L. acidophilus were isolated from parental strains suc

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2

Grossová, Marie. "Tvorba biofilmu u probiotických bakterií a jejich zpracování do pevné lékové formy." Doctoral thesis, Vysoké učení technické v Brně. Fakulta chemická, 2016. http://www.nusl.cz/ntk/nusl-263349.

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The aim of present work is cultivation of probiotic bacteria L. acidophilus, B. breve and B. longum in such a way that the culture forms cells clusters or comprehensive biofilm on the variety of free carriers. Biofilm formation of L. acidophilus on the silica from point of view bile and acid tolerance in gastrointestinal tract was studied. While the number of living cells in planktonic form (planktonic form) at pH 1 fell by 30 %, the viability of the biofilm cells was maintained to 90 % under the same environmental conditions. The biofilm culture showed also the protection against environment

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3

Villeger, Romain. "Etude in vitro des propriétés probiotiques de bactéries du genre Bacillus : Interaction avec l’hôte et effets de l’association avec un prébiotique." Thesis, Limoges, 2014. http://www.theses.fr/2014LIMO0066/document.

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Les probiotiques sont des microorganismes vivants qui, lorsqu’ils sont ingérés en quantité adéquate, peuvent exercer des propriétés bénéfiques sur la santé de l’hôte. Les souches de Bacillus utilisées en tant que probiotiques ne sont pas colonisatrices du tractus intestinal, mais sont des résidents transitoires du microbiote. Ce travail fait l’investigation in vitro de l’association, qualifiée de synbiotique, entre une souche probiotique de Bacillus subtilis et une source carbonée prébiotique, composé alimentaire peu digéré par les enzymes intestinales mais utilisable par les bactéries dans l’

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4

Benson, Gregory Martin. "Studies on bile acid sequestrants and bile acid metabolism in the hamster." Thesis, Royal Veterinary College (University of London), 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.518089.

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5

Torchia, Enrique C. "The role of intracellular bile acid binding proteins in bile acid transport and cytoprotection." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ60354.pdf.

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6

Trusova, Tatyana. "Quantitative estimation of bile acid conjugates in human bile using HPLC /." Connect to online version, 1995. http://hdl.handle.net/1989/3555.

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7

Zheng, Zhi-Ying 1957. "Bile acid-induced DNA damage in bacteria." Thesis, The University of Arizona, 1990. http://hdl.handle.net/10150/291421.

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Bile acids have been implicated by epidemiologic evidence as causative agents in colon cancer. Previous studies have indicated that the bile acids damage DNA. However, the conjugated forms of bile acids (eg. tauro conjugates) have not been tested for interaction with DNA. The present study compared the DNA-damaging ability of unconjugated and conjugated bile acids using the E. coli SOS test system. The E. coli tester strain was incubated with the bile acids and conjugated bile acids. Both cell survival and induction of the SOS response was measured. Among unconjugated bile acids, deoxycholate,

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8

Kiroff, George Kosta. "Oesophageal mucosal injury by acid and bile salt /." Title page, table of contents and summary only, 1986. http://web4.library.adelaide.edu.au/theses/09MS/09msk59.pdf.

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Thesis (M.S.)--University of Adelaide, Dept. of Surgery, 1989.<br>The experimental work described was performed in the Department of Surgery of the University of Adelaide during 1982-1983. Typescript (photocopy). Includes bibliographical references (leaves 191-211).

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9

Bajor, Antal. "Bile acid induced diarrhoea : pathophysiological and clinical aspects /." Göteborg : Dept. of Internal Medicine, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, 2008. http://hdl.handle.net/2077/9840.

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10

Pattni, Sanjeev. "Mechanisms of idiopathic bile acid malabsorption and diarrhoea." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/11109.

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Bile acid malabsorption or diarrhea (BAM or BAD) is a syndrome of chronic watery diarrhoea diagnosed predominantly by a SeHCAT test and less commonly by measuring levels of 7-hydroxy-4-cholesten-3-one (C4) and furthermore responds to bile acid sequestrants (BAS). Primary bile acid diarrhoea (PBAD) is the condition with no definitive cause and is under diagnosed, often being labelled as IBS-diarrhoea with an associated burden of disease for patients. Recently an alternative mechanism for PBAD involving impaired Fibroblast Growth Factor (FGF19) production has been proposed. Aims: The primary aim

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11

PULEO, Gianluigi. "Synthesis and use of bile acid derived organocatalysts." Doctoral thesis, Scuola Normale Superiore, 2009. http://hdl.handle.net/11384/85788.

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The central idea of this work was design, synthesis and study of catalytic activity and enantioselectivity of new organocatalysts containing a chiral cavity mimicking the enzymatic pocket of Aldolase I. Following the longstanding interest of our research group in the use of bile acid derivatives in enantioselective processes, attention was addressed to the development of organocatalysts having bile acid structure, where, because of its concave structure, due to the cis junction of the A and B cyclohexanic rings (Figure 3), the cholestanic backbone and the appended substituents should form a ch

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12

D'Souza, Lawrence Joseph. "Bile Acid Based Molecular Tweezers And Crown Ethers." Thesis, Indian Institute of Science, 1995. https://etd.iisc.ac.in/handle/2005/114.

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Chapter 1. Introduction to Molecular Tweezers Whitlock and Zimmerman developed a class of molecular hosts, popularly known as molecular tweezers, which sandwich aromatic guests by ii=ii interaction. Chapter 1 summarizes molecular tweezers of various kinds which have recently been synthesized. Chapter 2. Design and synthesis of "Bile Acid-Based Molecular Tweezers" Bile acids have a rigid backbone, and the array of hydroxyl groups separated by 5-7 A provides opportunities for the attachment of binding surfaces such as two extended chromophoric units.

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13

D'Souza, Lawrence Joseph. "Bile Acid Based Molecular Tweezers And Crown Ethers." Thesis, Indian Institute of Science, 1995. http://hdl.handle.net/2005/114.

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Chapter 1. Introduction to Molecular Tweezers Whitlock and Zimmerman developed a class of molecular hosts, popularly known as molecular tweezers, which sandwich aromatic guests by ii=ii interaction. Chapter 1 summarizes molecular tweezers of various kinds which have recently been synthesized. Chapter 2. Design and synthesis of "Bile Acid-Based Molecular Tweezers" Bile acids have a rigid backbone, and the array of hydroxyl groups separated by 5-7 A provides opportunities for the attachment of binding surfaces such as two extended chromophoric units.

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14

Morgan, Sherif. "The Bile Acid, Deoxycholic Acid, Modulates IGF-IR Function in Colon Cancer Cells." Diss., The University of Arizona, 2009. http://hdl.handle.net/10150/194122.

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Deoxycholic acid (DCA) is a secondary bile acid postulated to be involved in the etiology and the progression of colorectal cancer, but its specific mechanisms are not fully understood. DCA has been shown to induce apoptosis allowing selection for apoptosis-resistant cells, which highlights the importance of understanding the mechanisms of action of DCA. Previously, it has been demonstrated that DCA perturbs the plasma membrane, leading to the activation of receptor tyrosine kinases. Because the insulin-like growth factor-1 receptor (IGF-IR), a receptor tyrosine kinase, is demonstrated to pl

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15

Lundåsen, Thomas. "Studies on the hormonal regulation of bile acid synthesis /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-053-4/.

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16

Geenes, Victoria Louise. "Placental bile acid homeostasis in norma and pathological pregnancy." Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.508943.

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17

Jolly, Arthur James. "The role of acid and bile in oesophageal carcinogenesis." Thesis, University of Leeds, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.436434.

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18

Schultz, Francisca. "Bile acid signalling in the fetal heart and myometrium." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/58279.

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Intrahepatic Cholestasis of Pregnancy (ICP) is a liver disease that affects approximately 1% pregnancies in the United Kingdom. ICP is characterised by an increase in maternal serum bile acids (BA), as well as a change in bile acid composition, whereby the increase in primary bile acids, taurocholic acid (TC) and taurochenodeoxycholic acid (TCDCA) is most pronounced. ICP is characterised by maternal symptoms and can be complicated by adverse events for the fetus, the latter of which occur more commonly in pregnancies complicated by high maternal serum bile acid levels. Adverse events that may

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19

Opiyo, Monica Naomi. "The role of glucocorticoid metabolism in bile acid homeostasis." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25673.

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Alterations in glucocorticoid (GC) biosynthesis and metabolism are associated with a variety of pathophysiological disorders including cholestasis, diabetes and other metabolic disorders. Bile acids (BA) are also important modulators of metabolic functions and regulate cholesterol, triglyceride and glucose homeostasis as well as being critical for dietary fat digestion, enterohepatic function, and postprandial thermogenesis. In intact cells and in vivo, the 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme converts inactive GC precursors (cortisone in humans, and 11-dehydrocorticostero

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20

Watts, Joseph. "The synthesis of A-ring fluorinated bile acid analogues." Thesis, University of Southampton, 2016. https://eprints.soton.ac.uk/410301/.

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Bile acids are physiological detergent molecules with a function to absorb dietary lipids and hydrophobic molecules in the gastrointestinal tract. It has emerged that bile acids are also agonists for the FXR nuclear receptor and the TGR5 membrane-bound receptor, and are key in regulating metabolism via both genomic and non-genomic factors. It is also apparent that bile acids could play an important role in the treatment of Parkinson’s disease and some cancers. A number of pharmaceutical companies have developed selective BA receptor agonists, with some progressing through clinical trials for a

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21

li, qingjiang. "Chemical investigations into the physiology of bile acid skeletons." Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1354810854.

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22

Li, Tiangang. "PREGNANE X RECEPTOR REGULATION OF BILE ACID METABOLISM AND CHOLESTEROL HOMEOSTASIS." Kent State University / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=kent1132160196.

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23

Werry, Brian Scott. "Characterizing Bile Acid Association as a Ligand and in Micellization." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1386186690.

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24

Qian, Jiang. "Studies of Sulfur Reduction of Taurine and Taurine-Conjugated Bile Acids by Bile acid 7α-Dehydroxylating Bacteria". TopSCHOLAR®, 2000. http://digitalcommons.wku.edu/theses/694.

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Bile acids are C24 steroids that are derived in the liver from cholesterol and secreted into the intestinal lumen to aid in emulsification of dietary lipids and lipid-soluble vitamins. The indigenous intestinal microflora modify bile acids, producing up to 20 unique bile acid metabolites. The 7α-dehydroxylation of the bile acids is the most physiologically important bile acid biotransformation. All known intestinal bacteria capable of bile acid 7α-dehydroxylation are anaerobic, gram-positive rods of the genera Clostridium and Eubcicterium. Bile acid 7α-dehydroxylating bacteria often contain bi

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25

Ellis, Ewa C. S. "Use of primary human hepatocytes for elucidation of bile acid synthesis /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-424-0.

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26

Neilands, Jessica. "Acid tolerance of Streptococcus mutans biofilms /." [Malmö, Sweden] : Malmö University, Faculty of Odontology, Department of Oral Biology, 2007. http://www.mah.se/muep.

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27

Donnellan, Clare Fiona. "Gene expression in oesophageal cells following acid and bile exposure." Thesis, University of Leeds, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432643.

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28

Fitzpatrick, W. J. F. "Intrajejunal bile acid precipitation in health and following ileal resection." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599061.

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29

Hurley, J. P. "Novel bile acid-hydrogel systems as potential nedical device biomaterials." Thesis, Queen's University Belfast, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269055.

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30

Chaudhury, Saima. "The effect of ispaghula husk upon faecal bile acid excretion." Thesis, London South Bank University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367902.

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31

Wertheim, Betsy Chaitkin. "Physical Activity as a Determinant of Fecal Bile Acid Levels." Thesis, The University of Arizona, 2008. http://hdl.handle.net/10150/193380.

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Physical activity is protective against colon cancer, whereas colonic bile acid exposure is considered a risk factor. However, the relationship between physical activity and bile acid levels has not been well studied. A cross-sectional analysis of fecal bile acid levels was conducted for 735 colorectal adenoma formers of the ursodeoxycholic acid chemoprevention trial. Hours of recreational activity was found to be inversely related to total fecal bile acid concentrations among participants with low triglycerides, but not for those with high triglycerides. The distinct effects of physical activ

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32

Tierney, Juliann Jude. "The synthesis and testing of novel cholic acid based stationary phases." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247854.

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33

Slabbert, R. S. "Acid tolerance and organic acid susceptibility of selected food-borne pathogens." Interim : Interdisciplinary Journal, Vol 13, Issue 2: Central University of Technology Free State Bloemfontein, 2013. http://hdl.handle.net/11462/296.

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Published Article<br>The development of tolerance to low pH levels and the existence of cross-resistance may promote survival of bacteria in acidic foodstuff and in acidic environments such as the human stomach, in so doing escalating the probability of food poisoning. Similar to antimicrobial resistance developing, there is growing concern that effectiveness of organic acids may decrease as a result of the emergence of acid-tolerant food-borne pathogens. The objectives of this study were to determine the development of acid tolerance in selected food-borne pathogenic bacteria and to explore t

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34

Kaya, Yasemin. "Study of the baiE Gene in Bile Acid 7α-Dehydroxylating Bacteria". TopSCHOLAR®, 1998. http://digitalcommons.wku.edu/theses/315.

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Intestinal bile acid 7α-dehydroxylating bacteria have recently been implicated in cholesterol allstone disease. Eubacterium sp. V.P.I. 12708, a bile acid 7α-dehydroxylating bacterium, contains multiple bile acid inducible (bai) genes which encode the enzymes responsible for bile acid 7a-dehydroxylation. The baiE gene encodes a bile acid dehydratase activity in Eubacterium sp.V.P.I. 12708. Using the polymerase chain reaction assay we determined the presence or absence of baiE-like genes in five clostridial bile-acid 7α-dehydroxylating strains: Clostridium sp. TO-931, Clostridium sp. HD-17, Clos

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35

David, Michael. "Study of the baiG Gene in Bile Acid 7α-Dehydroxylating Bacteria". TopSCHOLAR®, 1999. http://digitalcommons.wku.edu/theses/747.

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Recently, intestinal bile acid 7α-dehydroxylating bacteria have been implicated in cholesterol gallstone disease. Eubacterium sp. strain V.P.I. 12708, a bile acid 7α-dehydroxylating bacteria, contains multiple bile acid inducible (bai) genes which are located on a large bai operon. Genes of this operon encode the enzymes responsible for bile acid 7α-dehydroxylation. The baiG gene encodes a bile acid transporter in Eubacterium sp. strain V.P.I. 12708. Utilizing the polymerase chain reaction I determined the presence or absence of baiG-like genes in six bile acid 7α-dehydroxylating strains: Clos

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36

Gälman, Cecilia. "Modulation of bile acid and cholesterol metabolism in health and disease /." Stockholm ; Karolinska institutet, 2004. http://diss.kib.ki.se/2004/91-7349-948-x.

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37

Styles, Nathan Allen. "The characterization of the subcellular localization of bile acid CoA:N-acyltransferase." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2007p/styles.pdf.

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38

Liu, Ju-Ling. "A conserved bile acid biosynthesis and secretion pathway in Caenorhabditis elegans." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=117035.

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The clk-1 mutants of the nematode Caenorhabditis elegans display a highly pleiotropic phenotype that includes an average slowing down, and deregulation of a number of physiological processes, including embryonic and post-embryonic development, aging, and several rhythmic behaviors. clk-1 encodes a conserved enzyme that is necessary for the biosynthesis of ubiquinone (coenzyme Q), a lipid-like molecule that functions as a transporter of electrons in the respiratory chain. One of the features affected in clk-1 mutants is the defecation cycle. Several defecation suppressors of clk-1 genes (dsc) w

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39

Aldhahrani, Adil Abdullah. "Studies on the pathophysiology of bile acid-induced inflammatory airways disease." Thesis, University of Newcastle upon Tyne, 2017. http://hdl.handle.net/10443/3949.

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Background: Gastro-oesophageal reflux and aspiration may be associated with airway disease. Bile acid aspiration has been shown to be prevalent among patients with advanced airway disease, which raises the concern that recurrent microaspiration of bile acids may cause airway epithelial injury which may lead to inflammatory airway disease. Objectives: To investigate the possible links between bile acids and lung injury which may cause pro-inflammatory cytokine release using BEAS- 2B, NCI-H292, 16HBE14o- and Calu-3 cell lines. Moreover, this study aimed at exploring whether primary bronchial epi

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40

Dempster, Andrew William. "The antimicrobial and bile acid mediated control of Clostridium difficile infection." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/52418/.

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Clostridium difficile is an anaerobic, Gram-positive, endospore forming bacillus and is the leading cause of nosocomial infection. Symptoms range from mild diarrhoea to the potentially fatal intestinal complications pseudomembranous colitis and toxic megacolon. The prerequisite for C. difficile infection (CDI) is the perturbation of the healthy microbiota of the gut by broad spectrum antibiotics. It is therefore important to develop therapies which take this in to account, either by minimal disruption of the resident gut microbiota, or by reinstating the protective nature of the gut microbiota

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41

Elderedge, Emelyn R. "Molecular, cellular and regulatory characterization of cholesterol 7#alpha#-hydroxylase." Thesis, University of Edinburgh, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328759.

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42

Jiang, Zhao-Yan. "Studies on cholesterol and bile acid metabolism in Chinese cholesterol gallstone patients." Stockholm, 2010. http://diss.kib.ki.se/2010/978-91-7409-844-0/.

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43

Modica, Salvatore. "Intestinal nuclear bile acid receptor FXR activity and regulation in colorectal cancer." Thesis, Open University, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.520777.

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44

Duncan, Kenneth William. "Development of a synthetic methodology towards novel bile acid and cholesterol analogues." Thesis, University of Strathclyde, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248838.

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45

Kandell, Risa Lynne. "Bile acid-induced DNA damage and repair in bacterial and mammalian cells." Diss., The University of Arizona, 1990. http://hdl.handle.net/10150/184976.

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Colon cancer is the second most common type of cancer in the United States. Its incidence is linked epidemiologically to high levels of bile acids in the feces. Bile acids have been implicated as promoters and cocarcinogens in the etiology of colon cancer and as comutagens and mutagens in bacteria. These observations suggest the hypothesis that bile acids may damage DNA. By using the DNA-damage inducible SOS system in Escherichia coli, this study shows that when bacteria are exposed to bile acids there is induction of the SOS repair system and preferential survival of cells undergoing repair.

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46

Sekiguchi, Yusuke. "Structural and functional studies of the Apical Sodium Dependent Bile Acid Transporter." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/30646.

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The apical sodium dependent transporter (ASBT) is responsible for the uptake of bile acids from the apical membrane of the ileum cell. Loss of function mutations of ASBT relate to several diseases, such as Crohn's disease and Primary Bile Acid Malabsorption (PBAM). It is also a target for drugs aimed at lowering cholesterol. The X-ray crystal structure of a bacterial homologue of ASBT, ASBTNM, was previously solved at 2.2Å. In order to understand mechanism of ASBT transport in more detail, further structural and functional information are required. In this thesis, a proteoliposome transport a

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47

Itoh, Shinji. "Roles of βklotho in the negative feedback regulation of bile acid synthesis". Kyoto University, 2005. http://hdl.handle.net/2433/144721.

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48

Krähenbühl, Stephan. "Impaired bile acid transport in an animal model of defective debrisoquine hydroxylation /." [S.l : s.n.], 1985. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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49

Sagar, Nidhi. "Describing the gut microbiome and metabolomic changes in bile acid diarrhoea (BAD)." Thesis, University of Warwick, 2017. http://wrap.warwick.ac.uk/101543/.

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The diagnosis of BAD is often missed or misdiagnosed for IBS-D as these conditions present similarly with chronic diarrhoea. The principal hindrance to diagnosis of BAD is limited access to the diagnostic SeHCAT scan. Mechanisms of aetiology underlying BAD have not been fully elucidated and to date, an alternative biomarker for BAD that is more accessible and patient preferable, has yet to make its way into clinical practice. One of the greatest scientific challenges this decade has been understanding the relationship between the gut microbiome, its functionality and role in human health. BAs

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50

COGLIATI, CLELIA. "NMR study of chicken Liver Bile Acid Binding Protein: interaction and dynamics." Doctoral thesis, Università degli Studi di Verona, 2010. http://hdl.handle.net/11562/343942.

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Il principale obiettivo di questo lavoro di tesi è lo studio del ruolo giocato da un ponte disolfuro sulle proprietà di legame di una proteina citosolica, la Liver Bile Acid Binding Protein (L-BABP), nella quale è naturalmente presente. In particolare si vuole far luce sulle capacità della proteina di legare Acidi Biliari (BA) e sulle sue proprietà funzionali. Gli acidi biliari circolano tra il fegato e l’intestino attraverso un meccanismo definito “circolazione enteroepatica”, il quale è fortemente regolato dagli stessi acidi biliari. Gli acidi biliari sono infatti in grado di influenzare l’e

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