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1

Morales, Wilfredo. A molecular orbital study on the interaction between BF₃ and the compounds dimethyl ether and perfluorodimethyl ether. [Washington, DC]: National Aeronautics and Space Administration, 1996.

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2

Augustinsson, Olof. A study of interactions concerning the control of acid/base, salt/water and body temperature homeostasis inthe goat. Uppsala: Sveriges Lantbruksuniversitet, 1989.

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3

Hyvönen, Riitta. Interactions between nematodes and other soil organisms in coniferous forest soils in relation to acid/base and nutrient status. Uppsala: Sveriges lantbruksuniversitet, Institutionen för ekologi och miljövård, 1994.

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4

Saluz, H. P. A laboratory guide for in vivo studies of DNA methylation and protein/DNA interactions. Basel: Birkhäuser Verlag, 1990.

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5

Acid-Base Interactions: Relevance to Adhesion Science & Technology. Brill Academic Publishers, 2000.

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6

Acid-Base Interactions: Relevance to Adhesion Science and Technology. Brill Academic Publishers, 1991.

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7

Olkkola, Klaus T., Hugo E. M. Vereecke, and Martin Luginbühl. Drug interactions in anaesthetic practice. Edited by Michel M. R. F. Struys. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199642045.003.0021.

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When two or more drugs are administered simultaneously, the pharmacological response may be greater or less than the sum of the effects of the individual drugs. One drug may antagonize or potentiate the effects of the other and there may be also qualitative differences in response. Although some drug interactions increase the toxicity or result in loss of therapeutic effect, others are beneficial. Indeed, modern anaesthetic techniques depend on beneficial drug interactions. A sound combination of drugs helps clinicians to increase both the efficacy and safety of drug treatment. Drugs may interact on a pharmaceutical, pharmacodynamic, or pharmacokinetic basis. Many pharmacodynamic interactions are predictable and can be avoided by the use of common sense. However, it is much more difficult to predict the likelihood of pharmacokinetic and pharmaceutical interactions despite good prior knowledge of pharmacokinetics and chemical properties of individual drugs. Pharmaceutical drug interactions usually occur before the drug is given to the patient and they are caused by chemical (such as acid–base, salt formation, oxidation–reduction, hydrolysis, or epimerization) or physical (such as adsorption/absorption or emulsion breaking) reactions. When drugs have a pharmacokinetic interaction, one drug alters the absorption, distribution, or the elimination of the other drug. Many pharmacokinetic drug interactions are due to inhibition or induction of cytochrome P450 enzymes. Pharmacodynamic drug interactions are caused by drugs having an effect on the same receptors or the same physiological system. This chapter gives anaesthetists an overview of clinically relevant perioperative drug interactions.
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8

Sanner, Martha Depecol, and Christine Hooper. A.D.A.M.(R) Interactive Physiology CD: Fluid, Electrolyte, and Acid/Base Balance. Benjamin-Cummings Pub Co, 1999.

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9

Mazzarelli, Joan. The use of base-modified nucleosides in studying protein-nucleic acid interactions / by Joan Mazzarelli. 1990.

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10

Interactive Physiology: Fluid, Electrolyte, & Acid/base Balance (Cd-rom for Windows And Macintosh)cd-rom. Addison Wesley Longman, 1999.

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11

Simbiosys. ABG Bloodgas Interpretation: An Interactive Tutorial for Blood Gas & Acid-Base Analysis (CD-ROM for Windows). Critical Concepts, Incorporated, 1997.

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12

(Editor), Herman F. Mark, Norbert Bikales (Editor), Charles G. Overberger (Editor), Georg Menges (Editor), and Jacqueline I. Kroschwitz (Editor), eds. Acid-Base Interactions to Vinyl Chloride Polymers, Supplement Volume, Encyclopedia of Polymer Science and Engineering, 2nd Edition. 2nd ed. Wiley-Interscience, 1989.

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13

Rodriguez, A. A., and A. A. Rodriguez. ABGs Interactive: Acid-Base & Renal Formulas and Med Interactive 2001: Interactive Clinical Applets for Healthcare Professionals (Card with mini CD-ROM for Windows 95/98/00/ME). 2nd ed. Scymed, 2001.

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14

Winyard, Paul. Human kidney development. Edited by Adrian Woolf. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0343.

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The kidneys perform diverse functions including excretion of nitrogenous waste products, homeostasis of water, electrolytes and acid–base balance, and hormone secretion. The simplest functional unit within the kidneys is the nephron, which consists of specialized segments from glomerulus, through proximal tubule, loop of Henle, and distal tubule. Human nephrogenesis starts with two stages of transient kidneys, termed the pronephros and mesonephros, and ends with development of a permanent organ from the metanephros on each side. The latter consists of just a few hundred cells when it is formed in the fifth week of pregnancy but progresses to a nephron endowment of between 0.6 to 1.3 million by the time nephrogenesis is completed at 32–36 weeks of gestation. Key events during this process include outgrowth of the epithelial ureteric bud from the mesonephric duct, interactions between the bud and the metanephric blastema (a specific region of mesenchyme) that cause the bud to branch and mesenchyme to condense, epithelialization of the mesenchyme to form proximal parts of the nephron, and differentiation of segment specific cells. Molecular control of these events is being unpicked with data from human genetic syndromes and animal models, and this chapter highlights several of the most important factors/systems involved. Increased understanding of development is not just relevant to congenital kidney malformations, but may also be important in designing rational therapies for diseases of the mature kidney where recapitulation of developmental pathways is common.
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15

Ryutaro, Utsumi, ed. Bacterial signal transduction: Networks and drug targets. New York: Springer Science+Business Media, 2008.

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