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Dissertations / Theses on the topic 'Acide α-aminé'

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Published: 4 June 2021

Last updated: 11 February 2022

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1

Patino, Nadia. "Peptides fluorés : intérêt et synthèse de peptides incorporant dans leur structure un acide α-aminé β-fluoré". Nice, 1989. http://www.theses.fr/1989NICE4274.

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2

Capra, Julien. "Synthèse biomimétique de composés azotés biologiquement actifs." Phd thesis, Université Paris Sud - Paris XI, 2011. http://tel.archives-ouvertes.fr/tel-00711703.

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Ce travail de thèse est consacré à la synthèse de composés azotés biologiquement actifs s'inspirant notamment d'une réaction biosynthétique. Dans un premier temps, nos travaux avaient pour but de développer une nouvelle voie d'accès aux acides α-aminés par une réaction d'isomérisation énantiosélective d'imines. Après différentes études préliminaires, les meilleurs précurseurs d'acides a-aminés par cette méthode que nous ayons identifiés sont les α-céto amides. L'isomérisation 1,3 d'une imine formée à partir d'un α-céto amide et de la diphénylméthanamine à l'aide de différents alcoolates chirau

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3

Liron, Mélanie. "Synthèse totale de la quinocarcine." Phd thesis, Ecole Polytechnique X, 2006. http://pastel.archives-ouvertes.fr/pastel-00002175.

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La quinocarcine appartient à la famille des tétrahydroisoquinoléines, produits naturels qui constituent de puissants agents cytotoxiques et possèdent de nombreuses activités biologiques telles qu'antitumorales et antibiotiques. Son intérêt biologique ainsi qu'un faible rendement d'extraction du milieu naturel ont fait d'elle une cible attrayante en synthèse organique. Dans le but d'effectuer la synthèse totale de la quinocarcine, plusieurs stratégies ont été envisagées pour construire la structure tétracyclique ABCD. Ces stratégies se sont appuyées sur différentes étapes clé comme des réaction

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4

Hu, Xiaobo. "Synthèse, analyses structurales et assemblage de foldamères oligoamide hydrosolubles à base de quinolines." Thesis, Bordeaux, 2017. http://www.theses.fr/2017BORD0611/document.

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La chimie des foldamères est un domaine de recherche en pleine expansion où les chimistes explorent la construction d’architectures artificielles variées mimant les structures repliées des biopolymères naturels. Les foldamères d’oligoamides quinoline, constituent une branche importante des foldamères montrant de nombreuses caractéristiques attractives, incluant la stabilité et la prédictibilité de leurs conformations repliées, qui en font de bons candidats pour des applications biologiques. Jusqu’à présent, la plupart des études sur les foldamères d’oligoamides quinolines ont été menées dans d

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5

Mai, Thi thoa. "Nouvelles voies d’accès à des acides alpha-aminés énantioenrichis par mémoire de chiralité ou chiralité gelée." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA112045.

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Les acides α-aminés non protéinogènes sont des composés riches d’applications et peuvent donner accès à des composés possédant des propriétés biologiques intéressantes ou à des analogues de peptides. Ainsi, de nombreuses méthodes de synthèse asymétrique ont été développées. Parmi celles-ci, seulement quelques méthodes utilisent la chiralité d’acides α -aminés tertiaires naturels pour accéder à des acides α -aminés quaternaires et il n’existe que peu de synthèses asymétriques absolues d’acides α -aminés tertiaires.Notre équipe a précédemment développé une méthode de synthèse d’acides α-aminés q

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6

Bease, Michael Kenneth. "Host structures for α-amino acids". Thesis, Heriot-Watt University, 2004. http://hdl.handle.net/10399/319.

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7

Bailey-Regnaut, Helene. "Host structures for α-amino acids". Thesis, Heriot-Watt University, 1998. http://hdl.handle.net/10399/607.

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8

Berthelot, Didier. "Synthesis of novel heterocyclic α-amino acids". Thesis, Open University, 2001. http://oro.open.ac.uk/19072/.

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This thesis describes the incorporation of heterocycles as part of an α-amino acid side-chain. Two methods were adopted. The first involved the alkylation of a pseudoephedrine glycinamide enolate using haloalkanes. The method was validated by making the naturally occurring amino acid phenylalanine. Subsequently naphthyl-, pyridyl-, biphenyl- and isoxazolyl- groups were successfully incorporated into the amino acid side chain. The enantiomeric excess of the product amino acids was found to be moderate (10-87%) due to poor diastereoselectivity in the key alkylation step. Moreover, the strict exp

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9

Goubet, D. C. M. "Asymmetric synthesis of α-amino acid derivatives". Thesis, Swansea University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.637081.

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A general background to α-amino acids is discussed in the first chapter. After a brief account on classification, properties and applications of these compounds, asymmetric processes leading to optically enriched residues are reviewed in detail. The second chapter describes the envisaged stereoselective approach towards these substrates involving Michael-type addition onto a chiral didehydroalanine derivative. Syntheses of α,β-unsaturated amino acids are reviewed after a brief section on Michael-type reactions. The preparation of a chiral didehydroamino acid residue has been investigated using

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10

Atkinson, Rachel Clare. "Asymmetric α-arylation of α-amino acids via rearrangement of urea derivatives". Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/asymmetric-alphaarylation-of-alphaamino-acids-via-rearrangement-of-urea-derivatives(0a24a74d-ad3e-4db8-9b56-a0dea53be889).html.

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Quaternary amino acids are biologically important and useful building blocks for both natural product and pharmaceutical targets. They can be made from their naturally occurring proteinogenic tertiary counterparts through methods such as alkylation. However, α-arylation of amino acids is challenging with only a small number of methods available, which are far from general and access only a limited substrate scope. The N to C rearrangement chemistry established in the Clayden group allowed us to develop a transition metal-free arylation of amino acid enolates. This works by intramolecular deliv

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11

Clayson, Joanne. "Synthetic approaches to α-fluorinated amino acids and peptides". Thesis, Heriot-Watt University, 1996. http://hdl.handle.net/10399/628.

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12

Mas-Roselló, Josep. "C-arylation and alkenylation of α-amino acid derivatives". Thesis, University of Bristol, 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.738542.

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13

Lewis, Kirk Alexander. "Stereoselective synthesis using aminyl radicals derived from α-amino acids". Thesis, Loughborough University, 1997. https://dspace.lboro.ac.uk/2134/32976.

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Chapter 1 is the introduction to the thesis. It contains an overview of amino acids and aminyl radicals. The amino acids section includes material on their synthesis through traditional methods and asymmetric syntheses, as well as the use of radical reactions in their formation. The aminyl radical section gives a description of the nature of the radical and then proceeds with general techniques for aminyl radical formation. A more detailed account of our own group's use of sulfenamides and imines in aminyl radical formation is ·covered and the chapter is ended with a look at the work of aminyl

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14

Takeuchi, Mifune. "Practical synthesis of optically active α,α-disubstituted α-amino acid derivatives by phase-transfer-catalyzed asymmetric alkylation". 京都大学 (Kyoto University), 2005. http://hdl.handle.net/2433/145113.

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15

Yu, Heewon. "Pseudopoly(amino acids) : a study of the synthesis and characterization of polyesters made from α-L-amino acids". Thesis, Massachusetts Institute of Technology, 1988. http://hdl.handle.net/1721.1/16498.

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16

Hallinan, Keith Oliver. "Synthetic and metabolic studies on β,γ-unsaturated α-amino acids". Thesis, University of Warwick, 1992. http://wrap.warwick.ac.uk/110385/.

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(1) Chapter three describes the attempted investigation of the mechanism of cepham formation catalysed by the enzyme isopenicillin N synthase of Acremonium cephalosporium. The stereochemistry of this cyclisation was to be investigated with a specifically labelled butyrate residue in the unnatural substrate. 8-(a-amino) adipoyl-cysteinyl- a-aminobutyric acid. The chiral methyl and methylene groups were to be synthesised by the tritiation of specifically deuterated vinylglycine. This, in turn, was to be prepared from phenyl (2-lrimcthylsilylethynyl) sulphone. Scrambling of the deuterium labellin

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17

Jumnah, Roshan. "Palladium-catalysed allylic amination in the formation of α-amino acids". Thesis, Loughborough University, 1995. https://dspace.lboro.ac.uk/2134/31905.

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The review of this thesis describes palladium catalysed allylic amination in the context of the mechanism and synthetic utility. Examples of alkene geometry, regioselectivity and net retention have been illustrated as a consequence of the amination mechanism. The synthetic aspects of palladium catalysed allylic amination consists of other examples of the formation of enantiomerically enriched allylic amines and amino acids.

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18

Basvani, Kaleswara Rao [Verfasser]. "Novel Cyclic α-Phosphino-α-amino Acids and α-Phosphonium Glycolates, P,O Ligands and Nickel Complexes / Kaleswara Rao Basvani". Greifswald : Universitätsbibliothek Greifswald, 2012. http://d-nb.info/1021298913/34.

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19

Parada, André Luís Duarte. "Caracterização da qualidade nutricional da carne de codorniz." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2019. http://hdl.handle.net/10400.5/18074.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>Dentro das aves de capoeira, a codorniz é simultaneamente usada para a produção de carne e ovo. A codorniz europeia (Coturnix coturnix) é simultaneamente uma espécie cinegética, sendo a caça à codorniz uma actividade venatória que agrega o interesse de muitos caçadores na Península Ibérica. A Codorniz japonesa (Coturnix japonica) é a espécie usada para produção de carne e ovo, sendo a Codorniz europeia criada essencialmente para a produção de carne. A ausência de estudo que compare a codorniz europeia silvática com a proveniente da p

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20

Brown, Stuart Andrew. "Dynamic kinetic resolution : synthesis of optically active α-amino acid derivatives". Thesis, University of Edinburgh, 1999. http://hdl.handle.net/1842/13058.

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The dynamic kinetic resolution of 2-phenyl-4-subsittuted-5(4<I>H</I>)-oxazolones 89a-g has been investigated as a method for the synthesis of optically active α-amino acid derivatives. The effects of lipase, [either Novozyme (<I>Candida antarctica </I>lipase B), or Lipozyme (<I>Rhizomucor miehei</I> lipase)], solvent, nucleophile, and the addition of external triethylamine to the reaction is described. When R<SUP>1</SUP> = Ph, an 88% yield and 98% enantiomeric excess (e.e.) of α-amino acid ester 96a was obtained with Novozyme<SUP>®</SUP> in acetonitrile as solvent. The synthesis of novel 5(4<I

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21

Olszewski, Tomasz Krzysztof. "Original syntheses of new biomolecules : from imidazole and thiazole derivatives of α-aminophosphonic acids and γ-amino-α, β-dihydroxy carboxylic acid derivatives to disaccharide mimics". Montpellier 2, 2006. http://www.theses.fr/2006MON20017.

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22

Gresika, Alexandra. "Nouveaux synthons contraints de type α-amino acides et PNA en vue de l’élaboration de bio-foldamères". Thesis, Université Côte d'Azur (ComUE), 2018. http://www.theses.fr/2018AZUR4104/document.

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Le but de cette thèse a concerné le développement de deux types de structures oligomériques contraintes, basées soit sur des dérivés non naturels d’acides aminés cycliques, soit sur des dimères cycliques de Peptide Nucleic Acids (PNA), en vue d’analyser leur tendance à adopter des conformations pré-organisées, imitant les conformations actives des protéines ou des acides nucléiques. La première partie de cette thèse a trait à l’élaboration de synthons clefs dérivant d’acides α-aminés cycliques non naturels (acides 4-oxopipécoliques 6-substitués), à leur utilisation potentielle dans la synthèse

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23

Mambrini, Antonin. "Couplage oxydant d'énolates et chimie microfluidique : deux nouvelles approches pour la synthèse énantiosélective d'acides α-aminés quaternaires par Mémoire de Chiralité". Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS456/document.

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Les acides α-aminés quaternaires permettent l’accès à des structures et dérivés peptidiques présentant des propriétés biologiques intéressantes. De nombreuses voies de synthèses asymétriques sont décrites dans la littérature. La voie de synthèse la plus utilisée est l’alkylation d’acides α-aminés tertiaires. Dans les versions énantioselectives décrites, peu utilisent la chiralité initiale des acides α-aminés tertiaires comme inducteurs de chiralité. La mémoire de chiralité est un des principes permettant l’accès à des acides α-aminés quaternaires énantioenrichis avec, comme unique source de ch

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24

Riccioli, Riccardo. "Stereodivergent synthesis of β-trifluoromethyl-α- amino acids by sequential catalytic processes". Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/16194/.

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In this work, a sequential organocatalytic process for the stereodivergent synthesis of β-trifluoromethyl-α-amino acids using Erlenmeyer azlactones as starting material is presented. The strategy developed consists of a sequential catalytic approach, employing two catalysts that act independently to control the absolute configuration of two different stereocenters. The first step is a catalytic asymmetric hydrogen transfer of the activated double bond of the azlactone promoted by a Jacobsen type thiourea and Hantzsch ester as hydride donor. The second step involves a nucleophilic addition of a

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25

Kumano, Takeshi. "Enantioselective Synthesis of Cyclic α-Amino Acids through Asymmetric Phase-Transfer Catalysis". 京都大学 (Kyoto University), 2013. http://hdl.handle.net/2433/179375.

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26

Fowler, Lindsay S. "Synthesis of unnatural enone-containing α-amino acids : precursors to chiral N-heterocycles". Thesis, University of Glasgow, 2011. http://theses.gla.ac.uk/2524/.

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A fast and efficient synthetic route was developed for the synthesis of a novel class of enone-containing alpha-amino acid. An amino acid-derived beta-ketophosphonate ester was subjected to Horner-Wadsworth-Emmons conditions using a variety of aldehydes to produce a diverse library of alpha,beta-unsaturated amino acids. E-Configured enone-containing amino acids were also deprotected using a two-stage approach to give the parent alpha-amino acids. A minor modification to the route enabled the synthesis of Z-configured enones via the Still-Gennari reaction. A small library of Z-enones was produc

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27

Xie, Sheng-Xue. "Enzymatic production of optically active acetylenic alcohols and α, β-diastereomeric amino acids". Kyoto University, 1999. http://hdl.handle.net/2433/181386.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第8010号<br>農博第1079号<br>新制||農||788(附属図書館)<br>学位論文||H11||N3314(農学部図書室)<br>UT51-99-S300<br>京都大学大学院農学研究科農芸化学専攻<br>(主査)教授清水昌, 教授上野民夫, 教授加藤暢夫<br>学位規則第4条第1項該当

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28

Roff, Geoffrey John. "A versatile chemo-enzymatic route to enantiomerically pure β-branched-α-amino acids". Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/12879.

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Enantiomerically pure β-branched-α-amino acids are important synthetic targets and a challenging group of compounds to prepare. A series of diastereoisomers of β-methylphenylalanine analogues have been prepared in enantiomerically pure form using a combination of chemo-and bio-catalysis. Starting from L-threonine methyl ester and proceeding <i>via </i>the vinyl halide with Suzuki chemistry, a range of β,β-disubstituted didehydroamino acids were obtained as their (<i>Z</i>)-isomers. Asymmetric hydrogenation of these alkenes, using either the [Rh(<i>R,R</i>)-Et-DuPhos(COD)BF<sub>4</sub> or [Rh(<

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29

Zhang, Ting, та 张婷. "Amphiphilic peptides containing alternating α-aminoxy acids and α-amino acids to mimic the α-helix of bak BH3 domain and disulfide bondas covalent linkage for stabilizing 7/8 helix". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47869409.

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The binding between the survival protein Bcl-xL and the death-promoting region of the Bcl-2-related protein Bak is one of the key protein-protein interactions in the regulation of programmed cell death (apoptosis). Since it is well recognized that the BH3 domain of Bak adopts an amphipathic α-helix to interact with Bcl-xL through hydrophobic and electrostatic effects, conformational studies and possible applications of the α-aminoxy acid-containing peptides as mimics of the α-helix of Bak BH3 domain have been carried out. The main results are summarized below. Four short peptides ZT1?Z

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30

Courant, Thibaut. "Multi-fonctionnalisation d’imines : synthèse de composés aminés α-β-fonctionnalisés par procédé photocatalysé et réactions asymétriques organocatalysées". Thesis, Paris 11, 2013. http://www.theses.fr/2013PA112308.

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Ce projet scientifique concerne le développement de nouvelles méthodes efficaces de fonctionnalisation d’imines par des procédés organocatalysés et photocatalysésDans un premier temps la réaction photocatalysée d’alkylation d’énamines en conditions douces à été étudiée. L’utilisation de photocatalyseurs sous forme de complexes organométalliques d’Iridium a permis de réaliser la double fonctionnalisation d’ènecarbamates, permettant ainsi d’obtenir des substituts d’imines hautement substitués. Ce procédé permet de s’affranchir de l’utilisation de métaux lourds et ne nécessite qu’une activation p

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31

Ishikawa, Kazuhiko. "STUDIES ON FUNCTIONAL AMINO ACID RESIDUES AND CATALYTIC MECHANISM OF MAMMALIAN α-AMYLASES". Kyoto University, 1992. http://hdl.handle.net/2433/78041.

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32

Duodu, Portia. "Site-specific photo-proteolysis of proteins and peptides by incorporation of unnatural amino acid : synthesis and characterization of photo-activatable α-amino acid". Strasbourg, 2010. http://www.theses.fr/2010STRA6228.

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Les structures protéiques impliquées dans les phénomènes physiologiques comme la coagulation sanguine, l’apoptose ou la signalisation membranaire, nécessitent souvent une activation préliminaire de leurs formes pro-protéines inactives. Le présent travail de thèse s’inscrit dans le domaine de la biochimie, et porte sur le développement d’une photo-protéase comme un outil moléculaire original et efficace pour l’étude dynamique de protéines par photorégulation de leur activité. Les photo-protéases adoptent un concept identique à celui des précurseurs photolabile de biomolécules; En effet, l’irrad

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33

Cadart, Timothée. "Fonctionnalisation énantiosélective des isoxazolidin-5-ones α-substituées dans des conditions de catalyse par transfert de phase : accès aux acides β2,2-aminés". Thesis, Normandie, 2017. http://www.theses.fr/2017NORMIR11.

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Le principal objectif de cette thèse a été d'exploiter des isoxazolidin-5-ones α-substituées aisément accessibles comme plateformes originales pour la synthèse d'acides β2,2-aminés énantiomériquement enrichis. Pour cela, nous avons montré que la catalyse par transfert de phase, avec l'utilisation de faibles quantités (2-3 mol%) d'un sel d'ammonium quaternaire énantiopur dédié, était l'outil adéquate pour la fonctionnalisation énantiosélective de la position α des isoxazolidin-5-ones et ainsi générer un centre quaternaire stéréogène. Cette stratégie organocatalytique a été appliquée à la créati

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34

Pingali, Subramanya. "Towards the Synthesis of Magnesidin." ScholarWorks@UNO, 2011. http://scholarworks.uno.edu/td/447.

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Magnesidin is a magnesium chelate of the 3-hexanoyl and 3-octanoyl tetramic acid derivatives isolated from Psuedomonas magensiorubra. Its activity against grampositive bacteria was found to be a specific target for Gingivitis, a dental plaque.Although the synthesis of magnesidin has been reported earlier, it was not reproducible. The highly polar nature and it’s ability to exhibit tautomerization makes their chemical behavior complex and difficult to predict its structure. A variety of reactions and an in depth understanding of the chemical structure is necessary to attain the synthesis of the

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35

Harding, Christopher Iain. "Development of a butanedione derived chiral glycine equivalent for the synthesis of α-amino acids". Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603689.

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Chapter one introduces non-proteinogenic α-amino acids and outlines strategies for their synthesis. It focuses in depth on anionic chiral glycine equivalents and examines their advantages and disadvantages. It also introduces the recent developments of a new chiral glycolic acid equivalent with the Ley group. Chapter two details the development of a new chiral glycine equivalent and the subsequent improvements to the synthetic route. Chapter three describes the use of the equivalent in metal enolate mono and dialylation reactions, and the deprotection of these products to form α-amino acids an

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36

Enright, Alexis. "Deracemisation of amines and α-amino acids using enzymes in combination with chemical reducing agents". Thesis, University of Edinburgh, 2001. http://hdl.handle.net/1842/13802.

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<i>RS</i>-a<i>-</i>Amino acids bearing a b- or g-substituent have been prepared using standard methods for a-amino acid synthesis. The deracemisation of <i>RS</i>-a-amino acids, using D-amino acid oxidase (DAAO) from <i>Trigonopsis variabilis</i> and hydride reducing agents, has been investigated. The enzyme has been shown to tolerate the b- and g-substituted a-amino acids as substrates. The use of NaCNBH<sub>3</sub> for the deracemisation of acyclic a-amino acids has been demonstrated for the first time. Screening of a random library of organisms was undertaken to identify novel oxidase enzym

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37

Navin, V. "One-Pot Synthesis Of Chiral Disulfides & Diselenides From α-Amino Acids Mediated By Ammonium Tetrathiomolybdate In Water". Thesis, Indian Institute of Science, 2001. http://hdl.handle.net/2005/268.

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We have described herein a convenient one-pot synthesis of lisulfides/diselenides from a-amino acids mediated by ammonium etrathiomolybdate in water. (Figure 1) (Figure) Figure 1 Transformation of α-amino acids into the corresponding tiiocyanates/selenocyanates/disulfides/diselenides Halo-de-amination of a-amino acids using HBr/NaNCte followed by treatment with ammonium tetrathiomolybdate (NH4)2]VloS4 jLb provided a general route for the the one-pot synthesis of chiral a,a' bis (dithio) carboxylic acids (Figure 1, 2b). The yields were moderate, limited mainly the moderate conversi

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38

Hirner, Sebastian. "New Methodologies in Organic Chemistry: Applications to the Synthesis of α-Amino Acids and Natural Products". Doctoral thesis, KTH, Organisk kemi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-11112.

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This thesis deals with the development and application of new synthetic methodology in organic chemistry. The first part describes the development of a new protocol for the synthesis of 3-pyrrolines by means of a microwave-assisted ring-expansion reaction of 2-vinylaziridines. In addition, this methodology is implemented as a key-step in a formal total synthesis of the antibiotic (-)-anisomycin. In the second part, a new methodology for the synthesis of arylglycines from Weinreb amides is described. In this procedure, a Grignard reagent is added to the iminium ion formed from the Weinreb amide

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39

Marshall, Liam R. "Synthesis of unnatural amino acids for the design of multi-metal binding α-helical coiled coils". Thesis, University of Sheffield, 2017. http://etheses.whiterose.ac.uk/19509/.

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40

Rezaei, Araghi Raheleh [Verfasser]. "α-helical coiled coil mimicry by alternating sequences of β- and γ-amino acids / Raheleh Rezaei Araghi". Berlin : Freie Universität Berlin, 2011. http://d-nb.info/1026069661/34.

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41

Harkiss, Alexander Hugh. "Synthesis of novel fluorescent heterocyclic-derived α-amino acids and the total syntheses of piperidine natural products". Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/8629/.

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During the course of this PhD, methodology for the synthesis of a series of novel, highly fluorescent pyridine-derived α-amino acids was developed. Enone-derived α-amino acids were subjected to an inverse electron demand hetero-Diels-Alder cycloaddition and aromatisation reaction, which led to a twelve-membered library of pyridine analogues. The optical properties of these compounds were analysed, with several exhibiting interesting fluorescent characteristics. One of the analogues was incorporated into a cell penetrating pentapeptide via solid phase peptide synthesis. The resulting hexapeptid

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Douat, Céline. "Nouvelle synthèse d' α-amino aldéhydes N-protégés/ incorporation post-synthèse de chaînes lipidiques dans des peptides sur support solide". Montpellier 1, 2001. http://www.theses.fr/2001MON13515.

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La première partie de cette thèse est consacrée à la mise au point d'une nouvelle méthode de synthèse d'a-aminoaldéhydes N-protégés. Les a-aminoaldéhydes interviennent dans la synthèse d'amino acides non naturels et dans la préparation de liaisons peptidiques modifiées. Nous proposons une méthode de formation d'a-aminoaldéhydes N-protégés ( Boc, Z ou Fmoc) par réduction de leurs amides de morpholine correspondants. Cette synthèse donne des résultats similaires, au niveau rendements et pureté optique, à ceux obtenues par la méthode de réduction des amides de Weinreb mais présente un avantage pa

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Baranovic, Jelena. "Structural and functional characterization of reconstituted α - amino - 3 - hydroxy - 5 - methyl - 4 - isoxazole propionic acid receptors". Thesis, University of Oxford, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.669954.

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Tinajero, Díaz Ernesto. "Hybrid block and graft copolymers made from macrolactones and α-amino acids for applications as drug delivery nanosystems". Doctoral thesis, Universitat Politècnica de Catalunya, 2019. http://hdl.handle.net/10803/667299.

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Naturally produced peptides or proteins can be regarded as highly refined polymers. When synthetic polymers are married to proteins or peptides, the resulting bioconjugates can synergistically combine the properties of the individual components and overcome their separate limitations. This Thesis is focused on the study of hybrid copolymers based on polypeptides and polymacrolactones. Block and graft copolymers have been synthesized by making use of the ring opening polymerization method (ROP) mainly and extensively characterized including both their chemical structure and their structure in t

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Wilson, Karen E. "Investigations into the role of α-amino acids as chiral modifiers for Ni-based enantioselective heterogeneous hydrogenation catalysts". Thesis, University of St Andrews, 2011. http://hdl.handle.net/10023/3108.

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The hydrogenation of β-ketoesters over chirally modified Ni catalysts is a celebrated and thoroughly researched example of an enantioselective heterogeneous catalytic reaction. Enantioselective heterogeneous processes, although extremely attractive in terms of fewer complications in the separation of products from the catalyst, are hindered in their viability as industrial applications due to the lack of detailed knowledge on how chirality is conferred to the metal surface. Surface science techniques have afforded substantial progress into determining mechanisms between modifier, reactant and

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Flamant-Robin, Céline. "Synthèse asymétrique d' α-acides aminés conformationnellement contraints et de lactames dipeptidiques avec incorporation dans les peptides bioactifs". Paris 11, 2003. http://www.theses.fr/2003PA112038.

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Les peptides jouent un rôle primordial dans divers systèmes biologiques en tant qu'hormones, neurotransmetteurs et neuromodulateurs. . . Ce qui leur confère un intérêt considérable. Néanmoins, certaines caractéristiques intrinsèques empêchent leur développement en médicaments. Certains de ces inconvénients peuvent être évités dans les composés peptidomimétiques. Ces composés peuvent être obtenus par l'introduction de contraintes conformationnelles dans les peptides bioactifs. Beaucoup de peptides bioactifs prennent la conformation en coude qui joue un rôle important dans la reconnaissance du r

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Khuphe, Mthulisi. "Biodegradable materials created by the controlled ring opening polymerisation of α-amino acid N-carboxyanhydrides and O-carboxyanhydrides". Thesis, University of Leeds, 2017. http://etheses.whiterose.ac.uk/17653/.

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Polymeric materials are excellent candidates for use as biomaterials. They are often employed as drug carriers to provide protection to encapsulated therapeutic molecules against premature metabolism, inactivation and clearance, and to reduce drug leakage and burst release, in vivo. Although significant progress in the medical sector has been registered, challenges still abound for the delivery of therapeutics. As such, the development of requisite nanocarriers and improvement of existing ones is crucial. NCA ROP and OCA ROP provide an alternative to solid phase peptide synthesis for the synth

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Kameda, Minoru. "Molecular design of N-spiro C2-symmetric chiral phase-transfer catalysts for practical asymmetric synthesis of α-amino acids". 京都大学 (Kyoto University), 2004. http://hdl.handle.net/2433/147838.

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Engqvist, Magnus. "Direct Amino Acid-Catalyzed Enantioselective α-Oxidation Reactions and Asymmetric de novo Synthesis of Carbohydrates". Doctoral thesis, Stockholms universitet, Institutionen för organisk kemi, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-449.

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The ability of amino acids to form nucleophilic enamines with aldehydes and ketones has been used in the development of asymmetric α-oxidation reactions with electrophilic oxidizing agents. Singlet molecular oxygen has for the first time been asymmetrically incorporated into aldehydes and ketones, and the products were isolated as their corresponding diols in good yields and ee’s. Organocatalytic α-oxidations of cyclic ketones with iodosobenzene and N-sulfonyloxaziridine were also possible and furnished after reduction the product diols in generally low yields and in low to good ee’s. Amino ac

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Nyakatura, Elisabeth K. [Verfasser]. "Studying the Interaction Profiles of Nonnatural Amino Acids – Towards Predicting their Specific Applications at α-Helical Interfaces / Elisabeth K. Nyakatura". Berlin : Freie Universität Berlin, 2013. http://d-nb.info/1045195049/34.

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