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Journal articles on the topic 'Acide pyrazolique'

Author: Grafiati

Published: 4 June 2021

Last updated: 4 February 2022

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1

El Mahdi, O., J. P. Lavergne, P. H. Viallefont, and M. Akssira. "SYNTHESE D'AMINO ACIDES PYRAZOLIQUES." Bulletin des Sociétés Chimiques Belges 104, no. 1 (2010): 31–37. http://dx.doi.org/10.1002/bscb.19951040107.

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2

Hajalsiddig, Tawassl Tajelsir Hassan, and Ahmed Elsadig Mohammed Saeed. "Synthesis of new 6-substituent 2-phenyl and 2-(furan-2-yl)-3-phenyl-quinoline-4-carboxylic acid derivatives." European Journal of Chemistry 10, no. 1 (2019): 57–63. http://dx.doi.org/10.5155/eurjchem.10.1.57-63.1816.

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A synthesis of substituted quinolines has been achieved by the Doebner reaction which is a three component coupling of arylaldehyde, p-amino-acetophenone and phenyl pyruvic acid. The products of 2,3-diary-6-acetyl-quinoline-4-carboxylic acids were obtained by Claisen Schmidt condensation reaction with aldehydes in the presence of sodium hydroxide in order to give the corresponding α,β-unsaturated carbonyls. The substituted α,β-unsaturated carbonyls were condensed with urea, thiourea, hydrazine, phenyl hydrazine, semicarbazide hydrochloride and ethanolamine to synthesized 2-pyrimidinone, 2-pyri

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3

KANG, YOUNG SOO, SUN WHA OH, and JONG HWA SUH. "PREPARATION AND CHARACTERIZATION OF ORGANIC THIN FILM OF STEARIC ACID/PYRAZOLINE NANOPARTICLES." International Journal of Nanoscience 05, no. 02n03 (2006): 199–205. http://dx.doi.org/10.1142/s0219581x06004243.

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The organic thin films of stearic acid/pyrazoline nanoparticles were prepared by transferring Langmuir monolayer of stearic acid/pyrazoline nanoparticle onto the solid substrate. The complex of stearic acid/pyrazoline nanoparticle was studied with pressure–area isotherm at the air/water interface and identified with linearly increasing optical absorbance around 370 nm by increasing the number of deposited layers. The in situ domain structure and molecular orientation of the complex were measured with BAM. The surface morphology of the Langmuir–Blodgett film was observed with AFM. The dispersio

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4

Nurlaili, Jasril, and Hilwan Yuda Teruna. "UJI AKTIVITAS ANTIOKSIDAN SENYAWA PIRAZOLIN 3-(2- METOKSI-FENIL)-5-NAFTALEN-1-IL-4,5-DIHIDRO-1H-PIRAZOL." Photon: Jurnal Sain dan Kesehatan 8, no. 2 (2018): 53–58. http://dx.doi.org/10.37859/jp.v8i2.716.

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Pyrazoline compounds are reported to have many useful biological activities such as antimicrobials, antihyperglycemia, antioxidants, anti-inflammatory, anticancer and anticonvulsants. The pyrazoline analogues of 3- (2-methoxy-phenyl) -5-naphthalene-1-yl-4,5-dihydro-1H-pyrazol were synthesized usingglacial acetic acid as catalyst and assisted by microwave irradiation. The structures of the compounds were obtainedby UV, IR and HRMS spectroscopy data. Antioxidant activity test using DPPH method showed that pyrazoline compound had IC50 value of 27.41 μg/mL.

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5

Park, Sang Won, Soong-Hyun Kim, Jaeyoung Song, et al. "Hypervalent iodine-mediated Ritter-type amidation of terminal alkenes: The synthesis of isoxazoline and pyrazoline cores." Beilstein Journal of Organic Chemistry 14 (May 11, 2018): 1028–33. http://dx.doi.org/10.3762/bjoc.14.89.

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Hypervalent iodine-mediated olefin functionalization provides a rapid gateway towards accessing both various heterocyclic cores and functional groups. In this regard, we have developed a Ritter-type alkene functionalization utilizing a PhI(OAc)2 ((diacetoxyiodo)benzene, PIDA)/Lewis acid combination in order to access isoxazoline and pyrazoline cores. Based on allyl ketone oximes and allyl ketone tosylhydrazones, we have developed an alkene oxyamidation and amido-amidation protocol en route to accessing both isoxazoline and pyrazoline cores. Additionally, acetonitrile serves as both the solvent

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6

Sultan, Mohammed Ibrahim, Ahmed M. Abdula, Rana I. Faeq, and Mahdi F. Radi. "New Pyrazoline Derivatives Containing Imine Moiety: Synthesis, Characterization and Antimicrobial Study." Al-Mustansiriyah Journal of Science 32, no. 3 (2021): 8. http://dx.doi.org/10.23851/mjs.v32i3.955.

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A new series of pyrazoline derivatives (3-10) have been synthesized and characterized on the basis of FT-IR, 1H-NMR, and Mass techniques. 1-(4-Aminophenyl)-3-(pyridin-4-yl)prop-2-en-1-one (1) as a starting material was prepared by the reaction of 4-aminoacetophenone and 4-pyridinecarboxaldehyde in ethanol, using sodium hydroxide as a catalyst. Pyrazoline derivatives 2 was obtained via the cyclization reaction of compound 1 by the action of hydrazine hydrate 80% in ethanol. The target derivatives (3-8) were obtained by the reaction of pyrazoline derivative (2) with the corresponding aldehyde in

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7

Guo, Shengmei, Yuyang Zhang, Jianyan Huang, Lin Kong, and Jiaxiang Yang. "High dual-state blue emission of a functionalized pyrazoline derivative for picric acid detection." CrystEngComm 23, no. 1 (2021): 221–26. http://dx.doi.org/10.1039/d0ce01195a.

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8

Maleki, Behrooz, Davood Azarifar, Khodaverdian Moghaddam, Fatemeh Hojati, Mostafa Gholizadeh, and Hafezeh Salehabadi. "Synthesis and characterization of a series of 1,3,5-trisubstituted-2-pyrazolines derivatives using methanoic acid under thermal condition." Journal of the Serbian Chemical Society 74, no. 12 (2009): 1371–76. http://dx.doi.org/10.2298/jsc0912371m.

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An efficient and practical synthesis of 1,3,5-trisubstituted 2-pyrazoline structures was achieved through cyclization of phenylhydrazine with ?,? -unsaturated ketones (chalcones) using methanoic acid (formic acid) as catalyst under thermal condition.

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9

Daneshfar, Zahra, and Ali Rostami. "Cellulose sulfonic acid as a green, efficient, and reusable catalyst for Nazarov cyclization of unactivated dienones and pyrazoline synthesis." RSC Advances 5, no. 127 (2015): 104695–707. http://dx.doi.org/10.1039/c5ra19773b.

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10

Lohidakshan, Krishnakumar, Manju Rajan, Andhale Ganesh, Mathew Paul, and Jithu Jerin. "Pass and Swiss ADME collaborated in silico docking approach to the synthesis of certain pyrazoline spacer compounds for dihydrofolate reductase inhibition and antimalarial activity." Bangladesh Journal of Pharmacology 13, no. 1 (2018): 23. http://dx.doi.org/10.3329/bjp.v13i1.33625.

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<p class="Abstract">New series of pyrazoline spacer compounds were prepared by the reaction between benzimidazole chalcones and (2-methyl-5-nitro-imidazole-1-yl)-acetic acid hydrazide by the sensible use of Michael addition. The building blocks used for the synthesis of pyrazoline derivatives were opted by using virtual screening by molinspiration search engine. The hypothetically resulted pyrazoline spacer compounds from this list are checked for their reliability on other in silico drug designing online web services like PASS online bioactivity, Swiss ADME predictor. The docking study

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11

Varghese, Beena, Saleh N. Al-Busafi, Fakhr Eldin O. Suliman, and Salma Al-Kindy. "Study on the Reactivity of Amino Acid Chemosensor, NPFNP, with Ethanol: Structural Elucidation through Single Crystal XRD and DFT Calculations." Sultan Qaboos University Journal for Science [SQUJS] 22, no. 1 (2017): 16. http://dx.doi.org/10.24200/squjs.vol22iss1pp16-28.

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A novel ethoxy derivative of an amino acid chemosensor, 3-naphthyl-1-phenyl-5-(2ʹ-fluoro-5ʹ-nitrophenyl)-2-pyrazoline (NPFNP), has been synthesized and characterized by different spectroscopic methods. A single crystal of the ethoxy derivative, 3-naphthyl-1-phenyl-5-(2ʹ-ethoxy-5ʹ-nitrophenyl)-2-pyrazoline NPENP, has been obtained and characterized. The structure holds interest as it carries biologically active pyrazoline as a central ring attaching to electron donating and withdrawing substituents. The major motivation for this work was to gain detailed insight into the structural parameters o

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12

Rathinamanivannan, S., K. Megha, Raja Chinnamanayakar, Ashok Kumar, and M. R. Ezhilarasi. "Synthesis and Characterization of 2-Pyrazoline Derivatives and their in silico and in vitro Studies on Antimicrobial and Anticancer Activities." Asian Journal of Chemistry 31, no. 10 (2019): 2191–96. http://dx.doi.org/10.14233/ajchem.2019.22082.

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The new series of 1-(4,5-dihydro-5-phenyl-3-diphenylpyrazol-1-yl)butan-1-one derivatives were synthesized by cyclization method using biphenyl chalcone with n-butyric acid and hydrazine hydrate. The synthesized 1-(4,5-dihydro-5-phenyl-3-diphenylpyrazol-1-yl)butan-1-one derivatives chemical structures were confirmed from spectral data such as FT-IR, 1H and 13C NMR. 2-Pyrazoline derivatives were docked with bacterial (1UAG) and breast cancer (1OQA) protein. Based on high binding affinity score, the best compound was subjected to in vitro anticancer activity by MTT assay. Also, antimicrobial acti

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13

Mistry, Rakesh N., and K. R. Desai. "Studies on Synthesis of Some Novel Heterocyclic Chalcone, Pyrazoline, Pyrimidine - 2 - One, Pyrimidine - 2 - Thione,para-Acetanilide Sulphonyl and Benzoyl Derivatives and their Antimicrobial Activity." E-Journal of Chemistry 2, no. 1 (2005): 30–41. http://dx.doi.org/10.1155/2005/953107.

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1, 2 - Dichloro benzene on chlorosulphonation by chlorosulphonic acid gives 1, 2 - [dichloro] - benzene sulphonyl chloride which on condensation withp–amino acetophenone gives 1-[acetyl] - 1’ , 2’ - [dichloro] - dibenz sulphonamide derivative. This derivative undergo condensation with 2,4- dichloro benzaldehyde gives 1- [3” - (sub. phenyl) - 2” - propene - 1” - one] - 1’ , 2’ - [dichloro] - dibenz sulphonamide derivative which on reaction with 99% hydrazine hydrate and glacial acetic acid gives 1-[acetyl]-3- [1’ , 2’ - (dichloro) - dibenz sulphonamide] -5 - [2” , 4” - dichloro phenyl] - 2 - py

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14

Revanasiddappa, B. C., M. Vijay Kumar, and Hemanth Kumar. "Synthesis and Antioxidant activity of novel Pyrazoline derivatives." Hygeia J. D.Med.10 (1) August 2018 - January 2019 10, no. 1 (2018): 43–49. http://dx.doi.org/10.15254/h.j.d.med.10.2018.177.

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Plan: A novel series of pyrazolines were synthesized through chalcones. The synthesized compounds were evaluated for various antioxidant activities. Preface: Pyrazolines belongs to five-membered nitrogen classes of compounds. Pyrazolines were reported with widespread chemotherapeutic activities. Methodology: A new series of Chalcones (2a-j) were prepared by reacting substituted aldehydes and ketones in alcohol medium in presence of NaOH. The chalcones (2a-j) undergoes selective cyclization with benzhydrazide (1) in glacial acetic acid medium to yield the title compounds 1, 3, 5-trisubstituted

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15

Journal, Baghdad Science. "Synthesis of New Pyrazoline - Phenoxathiin Derivatives." Baghdad Science Journal 10, no. 2 (2013): 405–19. http://dx.doi.org/10.21123/bsj.10.2.405-419.

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Phenoxathiin was prepared by the reaction of diphenyl ether with sulfur in the presence of anhydrous aluminum chloride. This work comprised the synthesis of new phenoxathiin derivatives containing heterocyclic moieties. These heterocyclic compounds were synthesized in three groups. The first group was made up of 2-(oxoalken-1-yl) phenoxathiin derivatives (3a-3j) obtained from the reaction of 2-acetylphenoxathiin with different aromatic aldehyde in the presence of sodium hydroxide. The other two groups involved compounds produced from the reaction of (3a-3j) with hydrazine hydrate in acetic aci

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16

Sonawane, V. D., B. D. Sonawane, M. J. Dhanavade, K. D. Sonawane, and R. B. Bhosale. "Design, Synthesis, Characterization, Anti-Inflammatory and Antioxidant Evaluation of Certain Novel Pyrazoline Derivatives Containing Imidazo[2,1-b]thiazole Moiety." Asian Journal of Organic & Medicinal Chemistry 5, no. 1 (2020): 45–50. http://dx.doi.org/10.14233/ajomc.2020.ajomc-p233.

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In present study, a novel series of substituted imidazo[2,1-b]thiazole pyrazoline derivatives (2a-e) and (3a-e) from the reference compound imidazo[2,1-b]thiazole chalcones (1a-e) in PEG-400 by using hydrazine hydrate and phenyl hydrazine was synthesized. Characterization of newly synthesized compounds was done using IR and 1H NMR. Further, imidazo[2,1-b]thiazole pyrazoline derivatives were subjected to check their in vitro antioxidant activities at a concentration of 0.5 mmol/L in methanol. Compounds 2c, 2d, 3c, 3d and 3e showed comparatively good activity than standard drug diclofenac. The a

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17

Gorpinchenko, V. A., D. V. Petrovcx, S. S. Lozhkin, E. G. Galkin, and V. A. Dokichev. "Catalytic hydrogenation of methyl esters of some 1h-pyrazoline-3-carboxylic acids." Chemistry of Heterocyclic Compounds 45, no. 10 (2009): 1202–7. http://dx.doi.org/10.1007/s10593-010-0408-2.

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18

Peerzade, Nargisbano Ayyub, Shravan Yegu Jadhav, Raghunath Bhikaji Bhosale, Amol Anantrao Kulkarni, and Bhushan Dnyandeo Varpe. "Synthesis, Docking, in silico ADMET and Pharmacological Evaluation of Some N-acetyl Pyrazole and Quinoline Conjugates." Letters in Drug Design & Discovery 17, no. 8 (2020): 1015–26. http://dx.doi.org/10.2174/1570180817666200228123347.

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Background: Pyrazolines are reported having anti-inflammatory, anti-oxidant and antidiabetic activities in the literature. Drugs like celecoxib, antipyrine, etc. are structurally similar to the designed compounds. Objectives: To synthesize and characterize N-acetyl pyrazole and quinoline conjugates and test them for Anti-inflammatory, Antioxidant, Antibacterial, Antiamylase and Antimalarial activities. Methods: A series of methoxy substituted quinoline based pyrazoline derivatives (2a-2j) were synthesized in good to excellent yield from corresponding quinoline chalcones (1a-1j). The synthesize

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19

Jois, Vidyashree, Balakrishna Kalluraya, and K. S. Girisha. "Synthesis and antioxidant activity study of pyrazoline carrying arylfuran/thiophene moiety." Journal of the Serbian Chemical Society 79, no. 12 (2014): 1469–75. http://dx.doi.org/10.2298/jsc140109090j.

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A novel series of N-acetyl-3-aryl-5-(5-(p/o-nitrophenyl)-2-arylfuryl/thienyl) substituted pyrazoline (3a-o) were synthesized by the reaction of 1-aryl-3-(5-(p/o-nitrophenyl)-2-furyl/thienyl)-2-propene-1-one with hydrazine hydrate in acetic acid medium. The structures of the newly synthesized compounds were established by IR, 1H NMR, mass spectra and single crystal X-ray study. The synthesized compounds were subjected to antioxidant activity using DPPH scavenging assay. The compounds 3a, 3f, 3h and 3o showed moderate activity.

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20

Abdel-Rahman, Reda M., Mohammad Saleh I. T. Makki, and Wafa A. Bawazir. "Synthesis of Some More Fluorine Heterocyclic Nitrogen Systems Derived From Sulfa Drugs as Photochemical Probe Agents for Inhibition of Vitiligo Disease-Part I." E-Journal of Chemistry 8, no. 1 (2011): 405–14. http://dx.doi.org/10.1155/2011/586063.

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Some more new bioactive fluorine heterocyclic systems containing sulfur and nitrogen as five-membered rings: pyrazoline, imidazole, imidazolopyrimidine, thiazolidinone and 1,2,4-triazole derivatives (3-13) have been synthetically derived from the interaction of sulfa drugs with fluorine aromatic aldehyde and/or hexa fluoroacetic anhydride followed by heterocyclization reactions. Former structures of the targets have been deduced upon the help of elemental and spectral data.. Compounds 7a-f, 10c and 13 could be used as photochemical probe agents for inhibition of Vitiligo diseases, in compare w

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21

Conti, P., A. Pinto, L. Tamborini, V. Rizzo, and C. De Micheli. "A regioselective route to 5-substituted pyrazole- and pyrazoline-3-phosphonic acids and esters." Tetrahedron 63, no. 25 (2007): 5554–60. http://dx.doi.org/10.1016/j.tet.2007.04.027.

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22

Gorpinchenko, V. A., D. V. Petrov, S. S. Lozhkin, E. G. Galkin, and V. A. Dokichev. "ChemInform Abstract: Catalytic Hydrogenation of Methyl Esters of Some 1H-Pyrazoline-3-carboxylic Acids." ChemInform 41, no. 29 (2010): no. http://dx.doi.org/10.1002/chin.201029124.

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23

Revanasiddappa, BC, MS Jisha, M. Vijay Kumar, and Hemanth Kumar. "Synthesis, Antibacterial and Antifungal Evlaution of Novel Pyrazoline Derivatives." Dhaka University Journal of Pharmaceutical Sciences 17, no. 2 (2018): 221–26. http://dx.doi.org/10.3329/dujps.v17i2.39179.

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A new series of chalcones (2a-j) were prepared by reacting substituted aldehydes and substituted ketones in alcohol medium in presence of NaOH. The chalcones underwent selective cyclization with guanicol hydrazide (1) in glacial acetic acid medium to yield the title compounds 1,3,5-trisubstituted pyrazolines (3a-j). The new compounds were characterized on the basis of 1H-NMR, IR and mass spectral data. All the newly synthesized compounds were evaluated for their in-vitro antibacterial and antifungal activities. Some of the tested compounds 3a and 3e showed good activity against bacterial strai

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24

Mantzanidou, Martha, Eleni Pontiki, and Dimitra Hadjipavlou-Litina. "Pyrazoles and Pyrazolines as Anti-Inflammatory Agents." Molecules 26, no. 11 (2021): 3439. http://dx.doi.org/10.3390/molecules26113439.

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The five-membered heterocyclic group of pyrazoles/pyrazolines plays important role in drug discovery. Pyrazoles and pyrazolines present a wide range of biological activities. The synthesis of the pyrazolines and pyrazole derivatives was accomplished via the condensation of the appropriate substituted aldehydes and acetophenones, suitable chalcones and hydrazine hydrate in absolute ethanol in the presence of drops of glacial acetic acid. The compounds are obtained in good yields 68–99% and their structure was confirmed using IR, 1H-NMR, 13C-NMR and elemental analysis. The novel derivatives were

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25

Zaib Un Nisa and Tashfeen Akhtar. "para-Aminobenzoic Acid-A Substrate of Immense Significance." Mini-Reviews in Organic Chemistry 17, no. 6 (2020): 686–700. http://dx.doi.org/10.2174/1570193x16666190828201234.

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PABA (p-aminobenzoic acid) is an important substrate for the synthesis of various biological scaffolds. Its pharmacological significance is apparent form the drugs like folic acid and benzocaine, which are used for certain biological disorders. Although, it is not a vitamin but still it is referred as a member of vitamin B. The deficiency of PABA leads to several disorders like erratic white areas of skin, grey hair, fatigue, depression and irritability. Besides its medicinal importance, PABA has been used in the synthesis of various biologically active heterocyclic nuclei like benzimidazoles,

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26

Masumoto, Eiichi, Hiroshi Maruoka, Fumi Okabe, et al. "A Novel Synthesis of 4-Pyridazineacetic AcidsviaRing Expansion ofN-Cyanomethylated 3-Pyrazoline-4-acetic Acids." Journal of Heterocyclic Chemistry 49, no. 4 (2012): 893–99. http://dx.doi.org/10.1002/jhet.894.

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27

Girisha, Marisiddaiah, Hemmige S. Yathirajan, Jerry P. Jasinski, and Christopher Glidewell. "Different acid–base behaviour of a pyrazole and an isoxazole with organic acids: crystal and molecular structures of the salt 3-(4-fluorophenyl)-1H-pyrazolium 2,4,6-trinitrophenolate and of the cocrystal 4-amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide–3,5-dinitrobenzoic acid (1/1)." Acta Crystallographica Section C Structural Chemistry 72, no. 8 (2016): 612–18. http://dx.doi.org/10.1107/s2053229616010494.

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Pyrazole and isoxazole rings differ only in the notional replacement of a potential hydrogen-bond-donor NH unit in pyrazole by a potential hydrogen-bond-acceptor O atom in isoxazole. It is thus of interest to compare the hydrogen-bonding characteristics of these rings. (4-Fluorophenyl)pyrazole undergoes protonation in the presence of 2,4,6-trinitrophenol to yield the salt 3-(4-fluorophenyl)-1H-pyrazolium 2,4,6-trinitrophenolate, C9H8FN2+·C6H2N3O7−, (I), whereas there is no proton transfer between 4-amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide and 3,5-dinitrobenzoic acid, whose reac

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28

Bhandarkar, Subodh, and Bhavana Khobragade. "Synthesis and Biological Study of 2-( 5-aryl-4,5-dihydro-1-substituted-pyrazol-3-yl )-Substituted-Naphthalene-1-Ol." Advanced Materials Research 1110 (June 2015): 306–10. http://dx.doi.org/10.4028/www.scientific.net/amr.1110.306.

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The literature survey reveals that pyrazoline derivatives have been studied extensively because of their ready accessibility, diverse chemical reactivity, broad spectrum of biological activity and variety of Industrial applications. Pyrazolines with sulphonamidoaryl substituent at 3-position show cerebroprotective, antidepressant activity , anti-implantation activity, hypoglycemic activity. Due to this vital biological roll of pyrazoline derivatives it was thought to synthesized titled pyrazolines. 2-Acetyl-1-naphthol is prepared by Modified Nenchi’s method which on treatment with furfuraldehy

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29

Appendino, Giovanni, Elisabetta Ghilardi, Giancarlo Cravotto та Pierluigi Gariboldi. "11,13-Methylenation of sesquiterpene exomethylene-γ-lactones: Synthesis of sesquiterpene cyclopropyl-γ-lactones". Collection of Czechoslovak Chemical Communications 56, № 5 (1991): 1052–63. http://dx.doi.org/10.1135/cccc19911052.

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11,13-Methylene derivatives of sesquiterpene exomethylene-γ-lactones were prepared by reaction of diazomethane and photolysis of the resulting pyrazoline adduct(s). Variable amounts of exomethylene- and ethylidene-γ-lactones were also formed in the photolysis reaction. These compounds could bee removed after reaction with diethylamine and chromatography on a bilayer (basic alumina/silica gel) column. Also 11,13-methylene derivatives of acid-and thermolabile germacranolides could be prepared in good yield with this procedure. Results obtained using alternative methods of methylenation are repor

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30

Patel, Pineshkumar N., and Denish C. Karia. "Synthesis and Antimicrobial Activity of Novel Series of Diversely Substituted Acetyl Pyrazoline Bearing Biphenyl Carbonitrile Motif." International Letters of Chemistry, Physics and Astronomy 69 (August 2016): 42–48. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.69.42.

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Novel series of diversely substituted acetyl pyrazoline having biphenyl carbonitrile motif have been synthesized. The reaction of 2-cyno-4’-bromomethyl biphenyl with1-(4-hydroxy-phenyl)-ethanone resulted in acetophenone derivative of biphenyl-2-carbonitrile. This acetophenone derivative was condensed with substituted aromatic aldehyde in mixed solvent resulted in various substituted chalcones. These chalcones were further cyclized using hydrazine hydrate in presence of glacial acetic acid to produce titled compound derivatives. The chemical structures of synthesized compounds were elucidated b

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31

Masumoto, Eiichi, Hiroshi Maruoka, Fumi Okabe, et al. "ChemInform Abstract: A Novel Synthesis of 4-Pyridazineacetic Acids (V) via Ring Expansion of N-Cyanomethylated 3-Pyrazoline-4-acetic Acids (IV)." ChemInform 44, no. 6 (2013): no. http://dx.doi.org/10.1002/chin.201306122.

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32

Journal, Baghdad Science. "Synthesis of New Heterocyclic Derivatives from 4-(3, 5-Dimethyl-1-phenyl-1H-pyrazol-4-ylazo)- benzoic acid." Baghdad Science Journal 7, no. 1 (2010): 727–36. http://dx.doi.org/10.21123/bsj.7.1.727-736.

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In this work pyrazolin derivatives were prepared from the diazonium chloride salt of 4-aminobenzoic acid. Azo compounds were prepared from the reaction of an ethanolic solution of sodium acetate and calculated amount of active methylene compound namely, acetyl acetone to obtain the corresponding hydrazono derivative (1). Cyclocondensation reaction of compounds (1) with hydrazine hydrate and phenyl hydrazine in boiling ethanol affording the corresponding pyrazoline-5-one derivatives of 4-aminobenzoic acid (2,3). Then compound (3) was reacted with thionyl chloride to give the corresponding acid

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33

Herfindo, Noval, Riska Prasetiawati, Daniel Sialagan, Neni Frimayanti та Adel Zamri. "Synthesis, Antiproliferative Activity and Molecular Docking Studies of 1,3,5-Triaryl Pyrazole Compound as Estrogen α Receptor Inhibitor Targeting MCF-7 Cells Line". Molekul 15, № 1 (2020): 18. http://dx.doi.org/10.20884/1.jm.2020.15.1.585.

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This research has been successfully synthesized three compounds of 1,3,5-triaryl pyrazole derivatives by two steps reaction. Firstly, pyrazoline (4a-c) compound was obtained by one-pot reaction of aromatic ketones, aldehyde and hydrazine in basic condition. Then, pyrazole (5a-c) compound was obtained by oxidative aromatization of compound 4 in the presense of acetic acid. Chemical structure of predicted molecules was confirmed by FTIR, NMR and HRMS spectroscopy data analysis. Antiproliferative activity of compound 5a-c were evaluated by in vitro assay against MCF-7 cells line and molecular doc

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34

Feng, Qi, Jiali Wang, Shiyuan Ding, Yang Chen, Guowang Diao, and Pingting Zhu. "Polymorphism and solvates of 1-acetyl-3-(phenyl)-5-(1-pyrenyl)pyrazoline: the structures, thermal and optical-physical properties." CrystEngComm 20, no. 5 (2018): 661–67. http://dx.doi.org/10.1039/c7ce01990d.

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Guerrero-Villalobos, Liliana Rocio, and FabiĂˇn Orozco LĂłpez. "RATIONAL DESIGN, SYNTHESIS AND CHARACTERIZATION OF HYBRID MOLECULES WITH PYRAZOLINE, PYRIMIDINE AND THIAZOLIDINE NUCLEI AS POTENTIAL ANTIBACTERIAL AGENTS." CBU International Conference Proceedings 5 (September 24, 2017): 1096–103. http://dx.doi.org/10.12955/cbup.v5.1077.

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In this paper, a set of computational tools were used to design and evaluate molecular structures resulting from the combination of the biologically interesting pyrazoline, aminopyrimidine and thiazolidine nuclei (molecular modification) to obtain new bioactive compounds. Key physicochemical properties were calculated (absorption, distribution, metabolism, excretion and toxicity), to determine the bioavailability of the designed compounds and to perform a preselection of 12 derivatives which were then optimized and studied by molecular docking with the receptor PBP3 (4bjp) from Escherichia col

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Jagdale, Deepali M., and Ramaa C. S. "QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP ANALYSIS OF NOVEL PYRAZOLINE DERIVATIVES USING K NEAREST NEIGHBOUR MOLECULAR FIELD ANALYSIS METHOD." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 12 (2017): 87. http://dx.doi.org/10.22159/ijpps.2017v9i12.19401.

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Objective: Malonyl CoA decarboxylase (MCD) enzyme plays important role in fatty acid and glucose oxidation. Inhibition of MCD might turn to a novel approach to treat ischemia. The main objective of this research article was to develop a novel pharmacophore for enhanced activity.Methods: Three-dimensional quantitative structure-activity relationships (3D-QSAR) was performed for pyrazoline derivatives as MCD inhibitors using VLife MDS 4.6 software. The QSAR model was developed using the stepwise 3D-QSAR kNN-MFA method.Results: The statistical results generated from kNN-MFA method indicated the s

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Yaster, Myron, Xiaowei Guan, Ronald S. Petralia, Jeffery D. Rothstein, Wei Lu, and Yuan-Xiang Tao. "Effect of Inhibition of Spinal Cord Glutamate Transporters on Inflammatory Pain Induced by Formalin and Complete Freund's Adjuvant." Anesthesiology 114, no. 2 (2011): 412–23. http://dx.doi.org/10.1097/aln.0b013e318205df50.

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Background Spinal cord glutamate transporters clear synaptically released glutamate and maintain normal sensory transmission. However, their ultrastructural localization is unknown. Moreover, whether and how they participate in inflammatory pain has not been carefully studied. Methods Immunogold labeling with electron microscopy was carried out to characterize synaptic and nonsynaptic localization of glutamate transporters in the superficial dorsal horn. Their expression and uptake activity after formalin- and complete Freund's adjuvant (CFA)-induced inflammation were evaluated by Western blot

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Jasril, Jasril, Hilwan Yuda Teruna, Aisyah Aisyah, Nurlaili Nurlaili, and Rudi Hendra. "Microwave Assisted Synthesis and Evaluation of Toxicity and Antioxidant Activity of Pyrazoline Derivatives." Indonesian Journal of Chemistry 19, no. 3 (2019): 583. http://dx.doi.org/10.22146/ijc.34285.

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Four pyrazoline analogues, 3-(4-methoxyphenyl)-5-naphthalene-1-yl-1-phenyl-4,5-dihydro-pyrazole (3), 3-(4-methoxyphenyl)-5-naphthalene-1-yl-4,5-dihydro-1H-pyrazole (4), 3-(2-methoxyphenyl)-5-naphthalene-1-yl-1-phenyl-4,5-dihydro-pyrazole (5) and 3-(2-methoxyphenyl)-5-naphthalene-1-yl-4,5-dihydro-1H-pyrazole (6) were synthesized via intermolecular cyclization between substituted chalcones and hydrazine derivatives. The compounds were synthesized in two steps. In the first step, the chalcones were synthesized by Claisen-Schmidt reaction. In the second step, they were cyclized with some hydrazine

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Clay, Sharon A., Donald C. Thill, and Verlan L. Cochran. "Response of Spring Barley (Hordeum vulgare) to Herbicides." Weed Technology 2, no. 1 (1988): 68–71. http://dx.doi.org/10.1017/s0890037x00030116.

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‘Karla’, ‘Klages', ‘Morex’, and ‘Steptoe’ cultivars of spring barley (Hordeum vulgareL.) differed in susceptibility to postemergence recommended application rates of diclofop {(±)-2-[4-(2,4-dichlorophenoxy) phenoxy] propanoic acid}, difenzoquat [1,2-dimethyl-3,5-diphenyl-1H-pyrazolium], chlorsulfuron {2-chloro-N-[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino] carbonyl] benzenesulfonamide}, and metribuzin [4-amino-6-(1,1-dimethylethyl)-3-(methylthio)-1,2,4-triazin-5(4H)-one] in 1981 and 1982. Metribuzin injured Morex, and difenzoquat injured all cultivars within 2 weeks after herbicide applicat

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Lakshminarayanan B, Kannappan N, Subburaju T, and Kalaichelvan V K. "Synthesis of some novel 3- (4-ethoxyphenyl) -5- (4-substituted) -4,5-dihydro-1H-pyrazole derivatives as potent antioxidant agents." International Journal of Research in Pharmaceutical Sciences 11, no. 2 (2020): 1571–77. http://dx.doi.org/10.26452/ijrps.v11i2.2035.

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Pyrazolines are the most useful heterocyclic moiety in Pharmaceutical and Chemical fields and as the most potential molecules for the design of new chemical entities. Nitrogen-containing heterocyclic compounds, pyrazolines and their derivatives showed a variety of pharmacological activities, including antioxidant properties. In the present study, eleven novel ethoxylated pyrazoline derivatives were synthesized by condensing chalcones with electron releasingethoxy group at one end and different electron-donating, electron-withdrawing groups in another end with hydrazine hydrate andalcohol. The

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El-Ossaily, Y. A. B., R. M. Zaki, and S. A. Metwally. "Investigation and Synthesis of Some Novel Spiro Heterocycles Related to Indoline Moiety." Journal of Scientific Research 6, no. 2 (2014): 293–307. http://dx.doi.org/10.3329/jsr.v6i2.17590.

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Reactions of indole-2,3-dione 1 with 2-mercaptobenzimidazole, o-phenylenediamine, 2-aminophenol, 2-aminobenzothiazole, 2-aminobenzimidazole and 3-methyl-1-phenyl-2-pyrazolin-5-one were carried out to give compounds spiroindolethiazetobenzimidazole 2, spirobenzimidazole(oxazole)indoline 3a,b, benzothiazol(imidazol) iminoindolinone 4a,b and methyloxoindolylidenepyrazolone 5 respectively. Compound 5 was reacted with 2-aminophenol as well as o-phenylenediamine to give new spirooxazepine and diazepine derivatives 6a,b respectively. Reaction of 5 with nitrogen nucleophiles as well as carbon nucleoph

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Ekawati, Linda, Bambang Purwono, and Muhammad Idham Darussalam Mardjan. "Synthesis N-Phenyl Pyrazoline from Dibenzalacetone and Heme Polymeration Inhibitory Activity (HPIA) Assay." Key Engineering Materials 840 (April 2020): 245–50. http://dx.doi.org/10.4028/www.scientific.net/kem.840.245.

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The synthesis of 1,5-diphenyl-3-styryl-4,5-dihydro-1H-pyrazole (B1) and 5-(3,4-dimethoxyphenyl)-3-(3,4-dimethoxystyryl)-1-phenyl-4,5-dihydro-1H-pyrazole (B2) have been conducted from 1,5-diphenylpenta-1,4-dien-3-on (A1) and 1,5-bis(3,4-dimethoxyphenyl)penta-1,4-dien-3-one (A2). Heme polymerization inhibitory activity (HPIA) assay of the synthesized compounds has also been carried out. The first step of reaction was Claisen-Schmidt condensation of benzaldehyde derivatives and acetone using NaOH 20% and ethanol as solvent. Dibenzalacetone derivatives were reacted with phenylhydrazine using aceti

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Chen, Jun, Philip R. Weinstein, and Steven H. Graham. "Attenuation of postischemic brain hypoperfusion and reperfusion injury by the cyclooxygenase—lipoxygenase inhibitor BW755C." Journal of Neurosurgery 83, no. 1 (1995): 99–104. http://dx.doi.org/10.3171/jns.1995.83.1.0099.

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✓ Arachidonic acid metabolites are believed to be important mediators of tissue injury during reperfusion after cerebral ischemia. To determine whether inhibiting the oxygen-dependent metabolism of arachidonic acid would reduce reperfusion injury, we administered the mixed cyclooxygenase—lipoxygenase inhibitor BW755C (3-amino-1-[m(trifluoromethyl) phenyl]-2-pyrazoline) near the time of reperfusion in a rat model of temporary focal ischemia. The duration of ischemia + reperfusion was 2 hours + 22 hours, 3 hours + 3 hours, or 3 hours + 21 hours. The effects of drug or saline treatment on infarct

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S. AL-Rawi, Muna, Huda A. Hassan, Dheefaf F. Hassan та Ismaeel Y. Majeed. "New Series of Substituted Heterocyclics Derived from α , β – Unsaturated Ketone and Their Cytotoxic Activity Tumor Cell Lines". Oriental Journal of Chemistry 34, № 6 (2018): 2826–31. http://dx.doi.org/10.13005/ojc/340620.

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The aldol condensation of 2-acetylnaphthalene with 9-anthracene carboxaldehyde afforded α, β-unsaturated keton (1) . New heterocyclic compounds containing: cyclohexenone[2], indazole[3], pyrimidinethion [4], thiazolo fused pyrimidine[5], isoxazoline[6], substituted pyrazoline[7]a-d and pyrimidinone[8] rings system were synthesized from α, β-unsaturated keton[1]. Cyclization of [1] with ethylacetoacetate gave the mentioned heterocycle cyclohexanone [2]. The cyclo condensation of [2] with hydrazine gave the new indazole derivative [3]. furthermore, the reation of [1]with thiourea gives thiopyrmi

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Zammit, Ramon, Maria Pappova, Esther Zammit, John Gabarretta, and David C. Magri. "1,3,5-Triarylpyrazolines — pH-driven off-on-off molecular logic devices based on a “receptor1-fluorophore-spacer-receptor2” format with internal charge transfer (ICT) and photoinduced electron transfer (PET) mechanisms." Canadian Journal of Chemistry 93, no. 2 (2015): 199–206. http://dx.doi.org/10.1139/cjc-2014-0266.

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The excited state photophysical properties of the 1,3,5-triarylpyrazolines 1–4 were studied in methanol and 1:1 (v/v) methanol–water, as well as 1:4 (v/v) methanol–water and water by fluorescence spectroscopy. The molecules 2–4 incorporate a “receptor1-fluorophore-spacer-receptor2” format while 1 is a reference compound based on a “fluorophore-receptor1” design. The molecular probes operate according to photoinduced electron transfer (PET) and internal charge transfer (ICT) processes. At basic and neutral pHs, 2–4 are essentially nonfluorescent due to PET from the electron-donating dimethylami

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Bajia, Birbal, and Y. K. Srivastava. "A Facile Solvent Free Microwave Induced Synthesis and Antibacterial Activity of Some 3-(2’-Hydroxyphenyl)-5-(Substituted Aryl)-2-Pyrazoline-N1-Caboxaldehydes." E-Journal of Chemistry 4, no. 2 (2007): 187–91. http://dx.doi.org/10.1155/2007/618289.

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A novel one pot formylation of 3-(2’-hydroxyphenyl)-5-(substituted 2-pyrazolines has been carried out using microwave irradiation with formic acid. solvent free reaction afforded title compounds in 80-90% yield with high purity.synthesized compounds were tested for their antibacterial activity using standard drug.

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Metwally, Saoud A. M., Moustafa F. Aly, Mohamed A. Abd-Alla, Ferial M. Atta та Maisa E. Abd-El-Monem. "Azomethine ylides from the reaction of 4-(dicyanomethylene)-3-methyl-1-phenyl-2-pyrazoline-5-one with α-amino acids and their esters". Liebigs Annalen der Chemie 1991, № 4 (1991): 387–89. http://dx.doi.org/10.1002/jlac.199119910168.

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Holt, Neal W., and Jim H. Hunter. "Annual Canarygrass (Phalaris canariensis) Tolerance and Weed Control Following Herbicide Application." Weed Science 35, no. 5 (1987): 673–77. http://dx.doi.org/10.1017/s004317450006077x.

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Field studies were conducted in Saskatchewan to evaluate the effect of herbicides on annual canarygrass (Phalaris canariensisL.) and associated weeds. Bromoxynil (3,5-dibromo-4-hydroxybenzonitrile) at 0.35 kg ai/ha, tank mixes of bromoxynil at 0.28 kg/ha plus the ester of MCPA [(4-chloro-2-methylphenoxy)acetic acid] at 0.28 kg ae/ha, linuron [N′-(3,4-dichlorophenyl)-N-methoxy-N-methylurea] at 0.28 kg ai/ha plus MCPA amine at 0.56 kg/ha, or propanil [N-(3,4-dichlorophenyI)propanamide] at 1.0 kg ai/ha plus MCPA ester at 0.28 kg/ha resulted in annual canarygrass seed and dry matter yields equal t

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DELGADO, G. E., P. DELGADO-NIÑO, R. LOBATON, S.-M. LIEW, and J. JAMALIS. "X-RAY POWDER DIFFRACTION DATA FOR A NEW PIRAZOLINE COMPOUND." Periódico Tchê Química 16, no. 33 (2019): 524–29. http://dx.doi.org/10.52571/ptq.v16.n33.2019.539_periodico33_pgs_524_529.pdf.

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Pyrazolines are important agents in medicinal chemistry as a promising scaffold for structural modification and drug development studies due to their wide range of biological activities such as anticancer, antifungal, antibacterial, antidepressant, anticonvulsant, antitubercular, antioxidant, antileishmanial and antiinflammatory activity. These heterocyclic compounds can be prepared by refluxing chalcone with hydrazine hydrate and anhydrous sodium acetate in the presence of glacial acetic acid. The structural characterization, molecular and crystalline structure, of these organic compounds, al

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METWALLY, S. A. M., M. F. ALY, M. A. ABD-ALLA, F. M. ATTA та M. E. ABD-EL-MONEM. "ChemInform Abstract: Azomethine Ylides from the Reaction of 4-(Dicyanomethylene)-3-methyl-1- phenyl-2-pyrazoline-5-one with α-Amino Acids and Their Esters." ChemInform 22, № 32 (2010): no. http://dx.doi.org/10.1002/chin.199132157.

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