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Relevant bibliographies by topics / Acidic tumor microenvironment / Dissertations / Theses

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Dissertations / Theses on the topic 'Acidic tumor microenvironment'

Author: Grafiati

Published: 15 June 2024

Last updated: 31 July 2025

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1

Audero, Madelaine. "Acidic tumor microenvironment and Ca2+ signaling interplay in Pancreatic Ductal Adenocarcinoma (PDAC) progression." Electronic Thesis or Diss., Université de Lille (2022-....), 2023. http://www.theses.fr/2023ULILS105.

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L'adénocarcinome canalaire pancréatique (PDAC) est une maladie mortelle caractérisée par un micro-environnement tumoral (TME) extrêmement acide (˂pHe 6,5) qui joue un rôle important dans son début et sa progression. Dans ce contexte, les canaux ioniques perméables au Ca2+ représentent de bons candidats cibles en raison de leur capacité à intégrer des signaux provenant de la TME. Les canaux Ca2+ sont en effet des capteurs de pH capables d'intégrer les signaux de la TME pour activer les voies intracellulaires en aval liées à la progression du PDAC. Bien que les rôles de l'acidose tumorale et de

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2

Schnipper, Julie. "The impact of the acidic tumor microenvironment on ion channel expression and regulation, in the progression of pancreatic ductal adenocarcinoma." Electronic Thesis or Diss., Amiens, 2022. http://www.theses.fr/2022AMIE0071.

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Le canal TRPC1 (pour transient receptor potential canonical 1) est l'un des canaux cationiques non sélectifs les plus impliqués dans plusieurs maladies, y compris la progression du cancer. Les TRPC peuvent être activés par différents stimuli physico-chimiques dont le pH. Par ailleurs, l'une des caractéristiques du cancer représente les variations pH extracellulaire, notamment dans l'adénocarcinome canalaire pancréatique (ACP). Il existe de fortes indications quant à l'agressivité de l'ACP qui est causée par l'interaction entre le microenvironnement acide de la tumeur et la dérégulation des can

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3

Assi, E. "ROLE OF ACID SPHINGOMYELINASE IN THE TUMOUR MICROENVIRONMENT." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/229416.

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Defective apoptosis represents one of the major causative factors in the development and progression of cancer. The ability of tumour cells to evade engagement of apoptosis can play a significant role in their resistance to conventional therapeutic regimens. In the last few years, preclinical and clinical studies have indicated ceramide and the enzymes of its metabolism, in particular Acid Sphingomyelinase (A-SMase) which hydrolyzes sphingomyelin to ceramide and phosphocoline, as key players in tumour physiopathology. Different cancers have been shown to have reduced ceramide levels and, of in

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4

Al-Husari, Maymona. "Mathematical modelling of the tumour microenvironment : the causes and consequences of tumour acidity." Thesis, University of Strathclyde, 2012. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=18965.

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Extracellular acidity and high levels of lactate are commonly observed in solid tumours. Some tumours also exhibit a reversed cellular pH gradient with an intracellular pH that is higher than the extracellular. This has been shown to play a crucial part in not only the invasive and metastatic cascade of tumours, but also on their response to therapies. In this thesis, we present four different mathematical models that examine the possible causes of tumour acidity and its effect on cell metabolism and tumour invasion. In the second chapter, we derive an ordinary differential equation model that

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5

Timosenko, Elina. "Tryptophan catabolism and amino acid transporter reprogramming in the tumour microenvironment." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:33745777-7aab-4342-b997-fc4317ec34fb.

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A large proportion of human tumours exploit tryptophan catabolism as a means to suppress T cell activity in the tumour microenvironment. However, the mechanisms that allow tumour cells to resist the detrimental effects of local tryptophan depletion have so far remained obscure. Here we demonstrate that shortage of tryptophan induced by the expression of tryptophan-degrading enzymes indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) results in ATF4-dependent reprogramming of the amino acid transporter expression profile in tumour cells. Specifically, we show that tumour cell

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6

Silva, Lídia [Verfasser], and Rüdiger [Akademischer Betreuer] Hell. "Branched-chain amino acid metabolism in the tumor microenvironment interaction / Lidia Silva ; Betreuer: Rüdiger Hell." Heidelberg : Universitätsbibliothek Heidelberg, 2018. http://d-nb.info/1177148897/34.

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7

Alruwaili, Waad A. "Conjugated Bile Acid and Sphingosine 1-phosophate prompt Cholangiocarcinoma Cell Growth via Releasing Exosomes." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5715.

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Cholangiocarcinoma (CCA) is a fatal primary malignancy that is formed in the bile ducts. Cancer-associated myofibroblasts play a crucial role in CCA proliferation and invasion. Furthermore, there is a growing interest in the role of the exosome in the interaction between the cancer-associated myofibroblasts and cholangiocarcinoma which lead to CCA growth. However how cholangiocarcinoma-derived exosome affect the cancer-associated myofibroblasts in the tumor microenvironment remain unknown. In this study, we examined whether exosome produced by cholangiocarcinoma could involve in the prompt of

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8

Dong, Jihu. "Physiopathologie de cellules souches cancéreuses isolées de glioblastomes primitifs et évaluation pré-clinique de molécules "tête de série" par une approche de biologie et de chimie médicinale." Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAJ036/document.

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Les glioblastomes sont des tumeurs primaires du cerveau les plus malignes. L’identification des cellules souches cancéreuses de glioblastome (CSGs) a transformé notre vision globale des glioblastomes en révélant une hiérarchie cellulaire au sein de ces tumeurs. Les CSGs sont douées de propriétés d’auto-renouvellement, de différenciation et peuvent entrer en quiescence. Elles sont considérées comme les cellules entretenant les tumeurs, responsables de leur dissémination et des rechutes après traitement. La découverte des CSGs a conduit à un changement de paradigme dans le développement des thér

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9

Sadiq, Barzan A. "A dissection of class I phosphoinositide 3-kinase signalling in mouse embryonic fibroblasts and prostate organoids." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/278056.

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Class I PI3Ks are a family (α, β, δ and γ) of ubiquitous lipid kinases that can be activated by cell surface receptors to 3-phosphorylate PI(4,5)P2 (phosphatidylinositol(4,5)-bisphosphate) and generate the signalling lipid PI(3,4,5)P3. The PI(3,4,5)P3 signal then activates a diverse collection of effector proteins involved in regulation of cell migration, metabolism and growth. The importance of this network is evidenced by the relatively high frequency with which cancers acquire gain-of-function mutations in this pathway and huge efforts to make PI3K inhibitors to treat cancer. The canonical

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10

Tang, Ching-Chun, and 湯景鈞. "Study on Acidic Tumor Microenvironment in Oral Cancer." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/m37yv5.

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碩士<br>國立臺灣大學<br>口腔生物科學研究所<br>107<br>The microenvironment of cancer cells is considered to be an important indicator of cancer progression. Studies have shown that due to the specific metabolic mechanisms of cancer cells, the extracellular matrix of cell has a higher hydrogen ion concentration than the cytoplasm. Exposure of cancer cells to this environment has an effect on their function, including changing in the metabolic system, mediating the growth processes, and expression of autophagy proteins. Compared with cancer within other parts of the body, the oral cavity is the only access to the

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11

Chen, Yu-Hsuan, and 陳羽萱. "Roles of Matrix Metalloproteinase 1 (MMP-1) in Acidic Pancreatic Tumor Microenvironment." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/j3hdvg.

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12

Wen-JuChung and 鍾雯如. "Clinical implication of squamous cell carcinoma antigen(SCCA)overexpression in acidic tumor microenvironment." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/07924706339876000152.

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碩士<br>國立成功大學<br>口腔醫學研究所<br>100<br>In clinical, tumor markers can be use to help cancer diagnosis , predict the patient’s response to particular therapies and follow-up disease. The squamous cell carcinoma antigen (SCCA) is a tumor marker and has a clinical value. In clinical diagnosis, patients with higher expression of SCCA show poor prognosis. However, SCCA in clinical use was more than 20 years, but the biological function and mechanism still remain unclear. Our previous studies, we found that overexpression of SCCA led to drug resistance, such as RSV (Resveratrol) and Cisplatin. Cancer cel

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13

BOUSSADIA, ZAIRA. "A new cell labelling strategy to study the biogenesis of exosomes and their role in human melanoma progression driven by microenvironmental acidic pH." Doctoral thesis, 2019. http://hdl.handle.net/11573/1227652.

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Gli esosomi sono nanovescicole di origine endosomiale, che rappresentano un mezzo importante di comunicazione cellula-cellula. Essendo coinvolti in diversi tipi di processi, sia fisiologici che patologici, sono diventati oggetto di sperimentazione clinica, nonostante molti meccanismi alla base della loro biogenesi rimangono tuttora sconosciuti. Quindi nel nostro laboratorio è stata messa a punto una metodica atta a produrre esosomi fluorescenti, in modo da poterne seguire la biogenesi nei diversi compartimenti intracellulari, il rilascio nell’ambiente extracellulare e la fusione con la

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14

BELLENGHI, MARIA. "Fatty acids role in cancer: Stearoyl-CoA desaturase 5 and its product oleic acid reduce melanoma dissemination by impairing tumor microenvironment." Doctoral thesis, 2017. http://hdl.handle.net/11573/936855.

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ABSTRACT Breakthroughs in the understanding of the basic biology of melanoma have yielded continue progresses on a variety of fronts. In the past decade, several specific inhibitors have been utilized against melanoma. However, after a short period of remission, their clinical use inevitably evidenced drug resistance and disease exacerbation. Finding new arms against the advanced phase of melanoma is one of the major challenges in the struggle against this cancer. New insight highlighted the rewiring of cellular signaling and the reprogramming of metabolic pathways in cancer. In normal cells

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15

Lima, Beatriz Vargas Cruz Antunes de. "Engineering Chitosan/Poly-(y-glutamic acid) nanoparticles to reshape the tumor microenvironment." Master's thesis, 2020. https://hdl.handle.net/10216/131418.

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Lima, Beatriz Vargas Cruz Antunes de. "Engineering Chitosan/Poly-(y-glutamic acid) nanoparticles to reshape the tumor microenvironment." Dissertação, 2020. https://hdl.handle.net/10216/131418.

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17

Bai, Yu-Chi, and 白育齊. "Mechanism analysis and effect of tumor microenvironment properties on the uptake of boric acid in human hepatoma HepG2 cells." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/7yt4a3.

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18

Hsieh, Chia-Yuan, and 謝佳芫. "Betulinic acid, a potent anticancer triterpenoid, induces endoplasmic reticulum stress in human gastric cancer cells and modulates the tumor microenvironment." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/6266aw.

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碩士<br>高雄醫學大學<br>藥學研究所<br>102<br>Gastric cancer is a high prevalent carcinoma and the leading cause of cancer-related mortality in Taiwan. Betulinic acid (BA), a triterpene isolated from the white birch tree, has been reported to exhibit anti-inflammatory and anti-tumor properties. However, the mechanisms of BA responsible for the induction of gastric cancer death remain unclear. The endoplasmic reticulum (ER) is a membranous network within cells, and it is important for several cellular functions, including translation, folding of secretory proteins and sequestration of Ca2+. ER homeostasis is

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