Academic literature on the topic 'Acinetobacter baumannii, RNA binding protein'

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Journal articles on the topic "Acinetobacter baumannii, RNA binding protein"

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Ciani, Caterina, Anna Pérez-Ràfols, Isabelle Bonomo, et al. "Identification and Characterization of an RRM-Containing, RNA Binding Protein in Acinetobacter baumannii." Biomolecules 12, no. 7 (2022): 922. http://dx.doi.org/10.3390/biom12070922.

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Acinetobacter baumannii is a Gram-negative pathogen, known to acquire resistance to antibiotics used in the clinic. The RNA-binding proteome of this bacterium is poorly characterized, in particular for what concerns the proteins containing RNA Recognition Motif (RRM). Here, we browsed the A. baumannii proteome for homologous proteins to the human HuR(ELAVL1), an RNA binding protein containing three RRMs. We identified a unique locus that we called AB-Elavl, coding for a protein with a single RRM with an average of 34% identity to the first HuR RRM. We also widen the research to the genomes of
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De Silva, P. Malaka, Rakesh Patidar, Christopher I. Graham, Ann Karen C. Brassinga, and Ayush kumar. "A response regulator protein with antar domain, AvnR, in Acinetobacter baumannii ATCC 17978 impacts its virulence and amino acid metabolism." Microbiology 166, no. 6 (2020): 554–66. http://dx.doi.org/10.1099/mic.0.000913.

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Acinetobacter baumannii, a Gram-negative coccobacillus, is notorious for its involvement in opportunistic infections around the world. Its resistance to antibiotics makes treatment of infections challenging. In this study, we describe a novel response regulator protein, AvnR (A1S_2006) that regulates virulence-related traits in A. baumannii ATCC17978. Sequence analysis suggests that AvnR is a CheY-like response regulator and contains the RNA-binding ANTAR (AmiR and NasR transcription anti-termination regulators) domain. We show that AvnR plays a role in regulating biofilm formation (on glass a
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Gao, Lili, and Xiaochun Ma. "Transcriptome Analysis of Acinetobacter baumannii in Rapid Response to Subinhibitory Concentration of Minocycline." International Journal of Environmental Research and Public Health 19, no. 23 (2022): 16095. http://dx.doi.org/10.3390/ijerph192316095.

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The increasing emergence of multidrug-resistant Acinetobacter baumannii brings great threats to public health. Minocycline is a kind of semisynthetic derivative of the antibacterial drug tetracycline and is often used to treat infections caused by multidrug-resistant A. baumannii with other antibiotics. However, minocycline-resistant A. baumannii appears constantly. To rapidly explore the response of A. baumannii to minocycline stress, RNA-seq was carried out to compare the difference in the transcriptome of A. baumannii ATCC19606 in the presence or absence of minocycline. The results showed t
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Roja, Pathakota, and V. Santhosh Kumar. "In-silico Docking and Toxicity Analysis of N-acetyl D- glucosamine with Antimicrobial Proteins- A Novel Targeting against Antimicrobial Resistance." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 14, no. 01 (2023): 66–75. http://dx.doi.org/10.25258/ijpqa.14.1.12.

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Nutraceuticals are popular health-promoting agents for various disease ailments such as food supplements, health promoters, etc. The rising antimicrobial resistance concerns are a serious challenge to researchers and need of the hour to be addressed by developing novel antimicrobial agents. One prospective nutraceutical that has been chosen as a candidate for development as an antibacterial agent is N-acetyl-D-glucosamine. GlcNAc is a monomer of chitin, a substance found in the cell walls of several fungi, mollusks, and cephalopod beaks. The present study aimed to evaluate NAG’s antimicrobial
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Oh, Kyu-Wan, Kyeongmin Kim, Md Maidul Islam, et al. "Transcriptional Regulation of the Outer Membrane Protein A in Acinetobacter baumannii." Microorganisms 8, no. 5 (2020): 706. http://dx.doi.org/10.3390/microorganisms8050706.

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Acinetobacter baumannii is known for its virulence in severely ill, hospitalized patients and for exhibiting multidrug resistance. A. baumannii infection treatment poses a serious problem in clinical environments. The outer membrane protein A (OmpA) of the Acinetobacter genus is involved in bacterial virulence. Regulatory factors of OmpA in the post-transcriptional stage have been previously identified. However, the regulatory factors that act before the transcriptional stage remain unclear. We investigated the A1S_0316 gene that encodes a putative transcription factor for OmpA expression in A
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Twana Salih and Hawzhin A. Salih. "In Silico Design and Molecular Docking Studies of Carbapenem Analogues Targeting Acinetobacter baumannii PBP1A Receptor." Al Mustansiriyah Journal of Pharmaceutical Sciences 20, no. 3 (2020): 35–50. http://dx.doi.org/10.32947/ajps.v20i3.759.

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Carbapenems are considered as the most effective antibiotic against Acinetobacter baumannii infections, as the pathogen has a resistance to the most of the other beta-lactam antibiotics; however, recent studies proved that this pathogen has developed
 resistance to carbapenems, as well. Therefore, development of novel therapeutics targeting A. baumannii resistant strains is an urgent global requirement. One of the causes responsible for this bacterial resistance against beta-lactam antibiotics is the decreased strength of interactions between A. baumannii Penicillin-Binding Proteins 1A (P
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Koenigs, Arno, Peter F. Zipfel, and Peter Kraiczy. "Translation Elongation Factor Tuf of Acinetobacter baumannii Is a Plasminogen-Binding Protein." PLOS ONE 10, no. 7 (2015): e0134418. http://dx.doi.org/10.1371/journal.pone.0134418.

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Suvaithenamudhan, Suvaiyarasan, Sivapunniyam Ananth, Vanitha Mariappan, et al. "In Silico Evaluation of Bioactive Compounds of Artemisia pallens Targeting the Efflux Protein of Multidrug-Resistant Acinetobacter baumannii (LAC-4 Strain)." Molecules 27, no. 16 (2022): 5188. http://dx.doi.org/10.3390/molecules27165188.

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Acinetobacter baumannii (A. baumannii) is one of the major representative aetiologies of recalcitrant nosocomial infections. Genotypic and phenotypic alterations in A. baumannii have resulted in a significant surge in multidrug resistance (MDR). Of all the factors responsible for the development of antimicrobial resistance (AMR), efflux protein pumps play a paramount role. In pursuit of a safe alternative for the prevention and control of A. baumannii infections, bioactive compounds from the aerial parts of the medicinal plant Artemisia pallens were studied. GC-MS analysis of the ethanol extra
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Patching, Simon G. "Spermidine Binding to the Acetinobacter baumannii Efflux Protein AceI Observed by Near-UV Synchrotron Radiation Circular Dichroism Spectroscopy." Radiation 2, no. 2 (2022): 228–33. http://dx.doi.org/10.3390/radiation2020016.

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The aim of this work was to test polyamines as potential natural substrates of the Acinetobacter baumannii chlorhexidine efflux protein AceI using near-UV synchrotron radiation circular dichroism (SRCD) spectroscopy. The Gram-negative bacterium A. Baumannii is a leading cause of hospital-acquired infections and an important foodborne pathogen. A. Baumannii strains are becoming increasingly resistant to antimicrobial agents, including the synthetic antiseptic chlorhexidine. AceI (144-residues) was the founding member of the recently recognised PACE family of bacterial multidrug efflux proteins.
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Gupta*, Debdoot, and Priya Mondal. "Drug Repurposing against Anhydro-N-acetylmuramic Acid Kinase of Multi-Drug Resistant Acinetobacter baumannii: An in Silico Approach." Biosciences Biotechnology Research Asia 20, no. 4 (2023): 1383–94. http://dx.doi.org/10.13005/bbra/3184.

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ABSTRACT: Acinetobacter baumannii, a gram-negative coccobacillus is accountable for different nosocomial diseases. It has been enlisted in the ‘critical’ category in WHO published list depending on the urgency for novel drug development as it becomes multidrug resistant (MDR). The aim of this study was to find a drug which can be repurposed against any drug target of these bacteria and thus the time and cost required for typical drug development procedure can be bypassed. In this study, Anhydro-N-acetylmuramic acid kinase (AnmK) of Acinetobacter baumannii was analyzed to be a good drug target
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Dissertations / Theses on the topic "Acinetobacter baumannii, RNA binding protein"

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Ciani, Caterina. "CHARACTERIZATION OF A NEW PUTATIVE ELAV-LIKE BINDING PROTEIN IN ACINETOBACTER BAUMANNII." Doctoral thesis, Università degli studi di Trento, 2022. http://hdl.handle.net/11572/335960.

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Post-transcriptional regulations (PTRs) have always been considered features of organisms with higher complexity. However recently, the interest toward the post- transcriptional mechanisms in prokaryotes increased. The bacterial proteome is much more complex compared to the genome size, suggesting a tight and articulate regulation of proteins production, extremely important for the bacterial adaptation to an always changing environment. Bacterial PTRs are responsible of modulation of mRNA stability and decay, translation initiation and elongation, modulation of the access of ribosome to the ri
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Book chapters on the topic "Acinetobacter baumannii, RNA binding protein"

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O.M. Al-Dahmoshi, Hussein, Noor S.K. Al-Khafaji, and Farah T. Al-Alaq. "Virulence and Antibiotic Resistance of Acinetobacter baumannii among Urinary Tract Infections." In Urinary Tract Infections - the Imbalance Between the Pathogen Virulence and the Host Defense [Working Title]. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.94508.

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Acinetobacter baumannii is one of the opportunistic bacteria firstly related with the hospital acquired infection influencing primarily to weakening the patient in the ICU. It is sometimes transferred to the patient by transient colonization of hands of the workers of healthcare, and persistence on eco-surfaces. Acinetobacter baumannii inhalation aerosolized through endo-tracheal suctioning of the ventilated patient is widespread among ventilator-related pneumonia (VAP). It is infections mainly associated with ventilator-related pneumonia (VAP), community Acquired Pneumonia (CAP), invasive bac
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