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Journal articles on the topic 'Acné rosacée'

Author: Grafiati

Published: 4 June 2021

Last updated: 15 February 2022

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1

Meunier, B., A. Darque, C. Bornet, G. Kaplanski, V. Devauchelle-Pensec, A. Saraux, L. Hoffart, and L. Chiche. "Une acné rosacée oculaire réfractaire traitée par collyre à l’anakinra." La Revue de Médecine Interne 35 (June 2014): A157. http://dx.doi.org/10.1016/j.revmed.2014.03.261.

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2

CEDEF. "Item 109 – UE 4 Dermatoses faciales : acné, rosacée, dermatite séborrhéique." Annales de Dermatologie et de Vénéréologie 142 (June 2015): S32—S41. http://dx.doi.org/10.1016/j.annder.2015.02.012.

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3

Yang, Lu, Yan-Hong Shou, Yong-Sheng Yang, and Jin-Hua Xu. "Elucidating the immune infiltration in acne and its comparison with rosacea by integrated bioinformatics analysis." PLOS ONE 16, no. 3 (March 24, 2021): e0248650. http://dx.doi.org/10.1371/journal.pone.0248650.

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Background Acne vulgaris and rosacea are common inflammatory complications of the skin, both characterized by abnormal infiltration of immune cells. The two diseases can be differentiated based on characteristic profile of the immune cell infiltrates at the periphery of disease lesions. In addition, dysregulated infiltration of immune cells not only occur in the acne lesions but also in non-lesional areas of patients with the disease, thus characterizing the immune infiltration in these sites can further enhance our understanding on the pathogenesis of acne. Methods Five microarray data-sets (GSE108110, GSE53795, GSE65914, GSE14905 and GSE78097) were downloaded from Gene Expression Omnibus. After removing the batch effects and normalizing the data, we applied the CIBERSORT algorithm combined with signature matrix LM22, to describe 22 types of immune cells’ infiltration in acne less than 48 hour (H) old, in comparation with non-lesional skin of acne patients, healthy skin and rosacea (including erythematotelangiectatic rosacea, papulopustular rosacea and phymatous rosacea) and we compared gene expression of Th1 and Th17-related molecules in acne, rosacea and healthy control. Results Compared with the non-lesional skin of acne patients, healthy individuals and rosacea patients, there is a significant increase in infiltration of neutrophils, monocytes and activated mast cells around the acne lesions, less than 48 H after their development. Contrarily, few naive CD4+ T cells, plasma cells, memory B cells and resting mast cells infiltrate acne sites compared to the aforementioned groups of individuals. Moreover, the infiltration of Regulatory T cells (Tregs) in acne lesions is substantially lower, relative to non-lesional sites of acne patients and skin of healthy individuals. In addition, non-lesional sites of acne patients exhibit lower infiltration of activated memory CD4+ T cells, plasma cells, memory B cells, M0 macrophages, neutrophils, resting mast cells but higher infiltration of Tregs and resting dendritic cells relative to skin of healthy individuals. Intriguingly, we found that among the 3 rosacea subtypes, the immune infiltration profile of papulopustular rosacea is the closest to that of acne lesions. In addition, through gene expression analysis of acne, rosacea and skin tissues of healthy individuals, we found a higher infiltration of Th1 and Th17 cells in acne lesions, relative to non-lesional skin areas of acne patients. Conclusions Our study provides new insights into the inflammatory pathogenesis of acne, and the difference between acne and rosacea, which helps in differentiating the two diseases. Our findings also guide on appropriate target therapy of the immune cell infiltrates in the two disease conditions.

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4

Copeland, Robert A. "ACNE/ROSACEA." Southern Medical Journal 86, Supplement (September 1993): 69. http://dx.doi.org/10.1097/00007611-199309001-00181.

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5

Webster, Guy F. "ACNE AND ROSACEA." Medical Clinics of North America 82, no. 5 (September 1998): 1145–54. http://dx.doi.org/10.1016/s0025-7125(05)70407-7.

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6

Thiboutot, Diane M. "ACNE AND ROSACEA." Dermatologic Clinics 18, no. 1 (January 2000): 63–71. http://dx.doi.org/10.1016/s0733-8635(05)70147-9.

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7

Picardo, Mauro, Lawrence F. Eichenfield, and Jerry Tan. "Acne and Rosacea." Dermatology and Therapy 7, S1 (January 2017): 43–52. http://dx.doi.org/10.1007/s13555-016-0168-8.

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8

Danby, F. W. "Rosacea, acne rosacea, and actinic telangiectasia." Journal of the American Academy of Dermatology 52, no. 3 (March 2005): 539–40. http://dx.doi.org/10.1016/j.jaad.2004.08.043.

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9

Rosen, Ted, and Mary Seabury Stone. "Acne rosacea in blacks." Journal of the American Academy of Dermatology 17, no. 1 (July 1987): 70–73. http://dx.doi.org/10.1016/s0190-9622(87)70173-x.

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10

Nuttall, Dilyse. "Calculation Skills: Acne Rosacea." Nurse Prescribing 14, no. 10 (October 2, 2016): 483. http://dx.doi.org/10.12968/npre.2016.14.10.483.

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11

Olisova, O. Yu, E. S. Snarskaya, O. V. Grabovskaya, N. P. Tepluyk, Anfisa A. Lepekhova, and A. S. Gasymova. "A rare combination of inverse acne and infiltrative-productive stage of rosacea." Russian Journal of Skin and Venereal Diseases 19, no. 3 (June 15, 2016): 158–61. http://dx.doi.org/10.18821/1560-9588-2016-19-3-158-161.

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The analysis of literature and exceptional clinical case of combination of inverse acne and infiltrative-productive stage of rosacea are presented. The historical facts, ethiopathogenesis, comorbidity, treatment, clinical picture and diagnostics with use of both standard and invasive methods of research (histological method) are described. Successful treatment of combination of inverse acne and an infiltrative-productive stage of rosacea with antibiotics and actinolyzat is reported.

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12

Ehlinger-Martin, A., JD de Korwin, E. Kué, A. Lozniewski, B. Legras, M. Weber, MC Conroy, JL Schmutz, and A. Ehlinger-Mart. "Absence d'association entre infection à Helicobacter pylori et acné rosaćée." La Revue de Médecine Interne 18 (May 1997): s218. http://dx.doi.org/10.1016/s0248-8663(97)80526-7.

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13

Odom, Richard. "Rosacea, acne rosacea, and actinic telangiectasia: In reply." Journal of the American Academy of Dermatology 53, no. 6 (December 2005): 1103–4. http://dx.doi.org/10.1016/j.jaad.2005.07.002.

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14

Watson, Kendra, Rachel Miest, and Megha Tollefson. "Isotretinoin for acne and rosacea." Seminars in Cutaneous Medicine and Surgery 35, no. 2 (June 2016): 79–86. http://dx.doi.org/10.12788/j.sder.2016.023.

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15

Diana Draelos, Zoe. "Cosmetics in acne and rosacea." Seminars in Cutaneous Medicine and Surgery 20, no. 3 (September 2001): 209–14. http://dx.doi.org/10.1053/sder.2001.27556.

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16

Roihu, Tia, and Arja-Leena Kariniemi. "Demodex mites in acne rosacea." Journal of Cutaneous Pathology 25, no. 10 (November 1998): 550–52. http://dx.doi.org/10.1111/j.1600-0560.1998.tb01739.x.

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17

Plewig, Gerd. "Management of severe acne rosacea." Clinical and Experimental Dermatology 27, no. 4 (June 2002): 328–37. http://dx.doi.org/10.1046/j.1365-2230.2002.104312.x.

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18

Ionescu, Marius-Anton A., M. Feuiolley, J. Enault, P. Wolkenstein, G. Robert, and L. Lefeuvre. "Acne, the microbiome and innate immunity." Russian Journal of Skin and Venereal Diseases 19, no. 5 (October 15, 2016): 279–82. http://dx.doi.org/10.18821/1560-9588-2016-19-5-279-282.

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In the laste years several articles focalized on human microbioma - the microorganisms from skin, mucosae, bowel - and on its role in chronic inflammatory diseases of the skin as acne, rosacea, atopic dermatitis, seborrheic dermatitis. In this article the authors present an update on particular acne skin’s microbioma, on innate immunity in acne and new physiopathology mecanisms described in inflammatory process in acne, and at the end we present in vitro, ex vivo and in vivo studies on the microbioma modulation and microbiofilm of pathogenic ribotypes of P. acnes leading to a significant improvement of acne in a series of 74 acne patients.

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19

Kim, Young Jae, Ik Jun Moon, Hae Woong Lee, Chong Hyun Won, Sung Eun Chang, Mi Woo Lee, Jee Ho Choi, and Woo Jin Lee. "The Efficacy and Safety of Dual-Frequency Ultrasound for Improving Skin Hydration and Erythema in Patients with Rosacea and Acne." Journal of Clinical Medicine 10, no. 4 (February 18, 2021): 834. http://dx.doi.org/10.3390/jcm10040834.

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Inflammatory skin diseases, such as rosacea and acne, are major causes of facial erythema and accompanying skin barrier dysfunction. Several methods to restore the impaired skin barrier and improve facial erythema, such as medication, radiofrequency, laser, and ultrasound therapy were attempted. This study evaluated the efficacy and safety of dual-frequency ultrasound with impulse mode, for improving skin hydration and erythema in Asian subjects with rosacea and acne. Twenty-six subjects with facial erythema received an ultrasound treatment once per week, for 4 weeks, over both cheeks. The erythema index and transepidermal water loss (TEWL) were measured at each visit. Clinicians assessed the erythema improvement and patients evaluated their satisfaction level. The average decrease in TEWL and erythema index at 6 weeks was 5.37 ± 13.22 g·h−1·m−2 (p = 0.020) and 39.73 ± 44.21 (p = 0.010), respectively. The clinician’s erythema assessment and the subject satisfaction questionnaire score significantly improved at final follow-up (p < 0.001; p = 0.003, respectively). No serious adverse effects were observed during the treatment and follow-up periods. The dual-frequency ultrasound with impulse mode appears to be effective and safe for improving skin hydration and erythema in patients with rosacea and acne.

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20

Aronson, Iris K., Jean A. Rumsfield, Dennis P. West, Julia Alexander, James H. Fischer, and Frank P. Paloucek. "Evaluation of Topical Metronidazole Gel in Acne Rosacea." Drug Intelligence & Clinical Pharmacy 21, no. 4 (April 1987): 346–51. http://dx.doi.org/10.1177/106002808702100410.

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Topical metronidazole gel (0.75%) was compared to placebo gel in a randomized, double-blind, placebo-controlled, split-face clinical trial for the treatment of 59 patients with acne rosacea. Statistically significant differences in inflammatory lesions, erythema, and global assessments were seen at three, six, and nine weeks post-baseline in favor of the active treatment side. It did not, however, alter the telangiectatic component of the disease. No known drug-related side effects were detected, and the low topical dose along with low serum levels of metronidazole indicate a high safety profile for this therapeutic agent. This work suggests that metronidazole gel, as specifically formulated, is safe and effective in reducing the symptomatology of acne rosacea.

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21

Bernardini, Francesco P., Robert C. Kersten, Lucie M. Khouri, Muhammad Moin, Dwight R. Kulwin, and Diya F. Mutasim. "Chronic eyelid lymphedema and acne rosacea." Ophthalmology 107, no. 12 (December 2000): 2220–23. http://dx.doi.org/10.1016/s0161-6420(00)00429-2.

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22

Keri, Jonette. "What’s new in acne and rosacea?" Seminars in Cutaneous Medicine and Surgery 35, no. 2 (June 2016): 103–6. http://dx.doi.org/10.12788/j.sder.2016.030.

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23

Stein Gold, MD,, Linda F., Andrew F. Alexis, MD, MPH, Julie C. Harper, MD, and Jerry K. L. Tan, MD, FRCPC. "Advances in Acne and Rosacea Therapy." Seminars in Cutaneous Medicine and Surgery 37, no. 3S (June 1, 2018): S63—S66. http://dx.doi.org/10.12788/j.sder.2018.025.

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24

PARISH, LAWRENCE CHARLES, and JOSEPH A. WITKOWSKI. "ACNE ROSACEA AND HELICOBACTER PYLORI BETROTHED." International Journal of Dermatology 34, no. 4 (April 1995): 236–37. http://dx.doi.org/10.1111/j.1365-4362.1995.tb01586.x.

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25

Buxton, P. K. "ABC of Dermatology: Acne and rosacea." BMJ 296, no. 6614 (January 2, 1988): 41–45. http://dx.doi.org/10.1136/bmj.296.6614.41.

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26

Wolf, Ronni. "Acne Rosacea and Helicobacter Pylori Betrothed." International Journal of Dermatology 35, no. 4 (April 1996): 302. http://dx.doi.org/10.1111/j.1365-4362.1996.tb03010.x.

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27

Patrinely, James R. "Granulomatous Acne Rosacea of the Eyelids." Archives of Ophthalmology 108, no. 4 (April 1, 1990): 561. http://dx.doi.org/10.1001/archopht.1990.01070060109059.

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28

Erzurum, Sergul A. "Acne Rosacea With Keratitis in Childhood." Archives of Ophthalmology 111, no. 2 (February 1, 1993): 228. http://dx.doi.org/10.1001/archopht.1993.01090020082028.

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29

Crawford, Capt Kevin M., Lt Col Brian Russ, and Maj Paul Bostrom. "Pimecrolimus for Treatment of Acne Rosacea." SKINmed: Dermatology for the Clinician 4, no. 3 (May 2005): 147–50. http://dx.doi.org/10.1111/j.1540-9740.2005.03740.x.

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30

Edwards, D. R. "Granulomatous acne rosacea of the eyelids." Journal of Oral and Maxillofacial Surgery 48, no. 12 (December 1990): 1350. http://dx.doi.org/10.1016/0278-2391(90)90517-6.

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31

Bhattarai, S., S. Agrawal, A. Rijal, S. Majhi, B. Pradhan, and SS Dhakal. "The Study of Prevalence of Helicobacter Pylori in Patients with Acne Rosacea." Kathmandu University Medical Journal 10, no. 4 (September 3, 2014): 49–52. http://dx.doi.org/10.3126/kumj.v10i4.10995.

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Background Acne rosacea is an inflammatory disease affecting the central part of the face characterized by erythema, papules, papulo pustules and telangiectasias of unknown etiology. More recently numerous studies have described an association with Helicobacter pylori (Hp) and the extra gastric symptoms of cutaneous origin. Objectives To establish the prevalence of Helicobacter pylori (Hp) infection in the stomach in patients with rosacea based on standard Hp serological test. Methods All patients with the clinical staging of 2, 3 and 4 rosacea attending the Dermatology Out Patient Department from May 2009 – April 2010 were included in the study. Quantitative serological test using the SERION ELISA classic Helicobacter pylori IgG was done. Result A total of 26 patients were enrolled in the study with the age ranging from 26- 82 years. There were 14 males and 12 females and the male: female ratio was 1.6:1. Three (11.53%) patients presented with Grade IV rosacea, a severe clinical presentation and symptoms suggestive of acid peptic diseases were found in 14/26 (53.8%) patients. A positive serology to H. pylori was found in 17/26 (65.4%) of patients. A statistically significant correlation was found when association of H.pylori positivity in patients of rosacea compared with the seropositivity in controls. However correlation in the seropositivity was not found amongst the patients having gastritis and rosacea. Conclusion There still proves to find a correlation of Hp infection with patients with rosacea but it can still be hypothesised as a cutaneous manifestation of an internal peptic ulcer disease . DOI: http://dx.doi.org/10.3126/kumj.v10i4.10995 Kathmandu Univ Med J 2012;10(4):49-52

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32

Lukaviciute, Laura, Ruta Ganceviciene, Petras Navickas, Alvydas Navickas, Jurate Grigaitiene, and Christos C. Zouboulis. "Anxiety, Depression, and Suicidal Ideation amongst Patients with Facial Dermatoses (Acne, Rosacea, Perioral Dermatitis, and Folliculitis) in Lithuania." Dermatology 236, no. 4 (2020): 314–22. http://dx.doi.org/10.1159/000506627.

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Background/Objective: Skin diseases, especially those with visible manifestation, are considered to cause a major influence on global mental health. Therefore, we determined the prevalence and severity of anxiety, depression, and suicidal ideation in a large sample of patients with facial dermatoses, namely acne, rosacea, folliculitis, and perioral dermatitis. Methods: The mental health of patients with facial dermatoses and respective controls was assessed using the Hospital Anxiety and Depression Scale and questions concerning suicidal ideation. Results: The study included 543 patients with facial dermatoses and 497 healthy individuals. Anxiety was present in 37.6% of the patients (14.9% of controls), depression in 21.7% (6.8%), and suicidal thoughts in 9.8% (3.2%) (p < 0.001). Acne patients demonstrated the highest anxiety and depression subscale scores (mean ± standard deviation: 7.1 ± 0.25, 95% confidence interval (CI): 6.58–7.56; controls: 5 ± 0.23, 95% CI: 4.57–5.49). In rosacea 30% of the patients had depression symptoms (adjusted odds ratio (OR): 7.216, 95% CI: 4.122–12.632, p < 0.001), while in folliculitis patients 15.4% (OR: 3.138, 95% CI: 1.241–7.936, p = 0.016) had suicidal thoughts. Patients with anxiety symptoms and suicidal thoughts were on average younger than those without (28.3 ± 0.76 vs. 31.2 ± 0.66 years, p = 0.001 and 25.3 ± 0.98 vs. 30.5 ± 0.55 years, p = 0.007, respectively). Conclusion: Acne and rosacea are associated with anxiety, depression, and suicidal ideation in Lithuanian patients. Younger patients are more prone to report such symptoms than older ones.

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33

Webster, Guy F. "Acne vulgaris and rosacea: Evaluation and management." Clinical Cornerstone 4, no. 1 (January 2001): 15–22. http://dx.doi.org/10.1016/s1098-3597(01)90003-1.

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34

Jalian, H. Ray, Yakir Levin, and Molly Wanner. "Physical modalities for treating acne and rosacea." Seminars in Cutaneous Medicine and Surgery 35, no. 2 (June 2016): 96–102. http://dx.doi.org/10.12788/j.sder.2016.028.

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35

Graber, Emmy. "Therapeutic Approach to Acne and Rosacea, Introduction." Seminars in Cutaneous Medicine and Surgery 35, no. 2 (June 2016): 49. http://dx.doi.org/10.12788/j.sder.2016.040.

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36

Harvey, David T., Neil A. Fenske, and L. Frank Glass. "PERSISTENT FACIAL EDEMA DUE TO ACNE ROSACEA." Southern Medical Journal 88 (October 1995): S33. http://dx.doi.org/10.1097/00007611-199510001-00058.

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37

Parish, Lawrence Charles, and Joseph A. Witkowski. "Reply: Acne Rosacea and Helicobacter Pylori Betrothed." International Journal of Dermatology 35, no. 4 (April 1996): 302. http://dx.doi.org/10.1111/j.1365-4362.1996.tb03011.x.

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38

Rebora, Alfredo, and Francesco Drago. "Reply: Acne Rosacea and Helicobacter Pylori Betrothed." International Journal of Dermatology 35, no. 4 (April 1996): 302–3. http://dx.doi.org/10.1111/j.1365-4362.1996.tb03012.x.

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39

Joseph B., Bikowski. "Subantimicrobial Dose Doxycycline for Acne and Rosacea." SKINmed: Dermatology for the Clinician 2, no. 4 (July 2003): 234–46. http://dx.doi.org/10.1111/j.1540-9740.2003.03014.x.

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40

Rollins, Susan D., and Patricia Sheets. "Fine-needle aspiration cytology of acne rosacea." Diagnostic Cytopathology 23, no. 2 (2000): 106–7. http://dx.doi.org/10.1002/1097-0339(200008)23:2<106::aid-dc8>3.0.co;2-t.

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41

LAW, TERESA H., IAN T. JACKSON, and SIGFRID A. MULLER. "Nasal Septal Carcinoma Masquerading as Acne Rosacea." Journal of Dermatologic Surgery and Oncology 13, no. 9 (September 1987): 1021–25. http://dx.doi.org/10.1111/j.1524-4725.1987.tb00580.x.

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42

MAYS, RANA MAJD, RACHEL A. GORDON, JANICE M. WILSON, and SIRUNYA SILAPUNT. "New antibiotic therapies for acne and rosacea." Dermatologic Therapy 25, no. 1 (January 2012): 23–37. http://dx.doi.org/10.1111/j.1529-8019.2012.01497.x.

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43

Lomeo, Paul, John McDonald, and Judith Finneman. "Rhinophyma: Treatment with CO2 Laser." Ear, Nose & Throat Journal 76, no. 10 (October 1997): 740–43. http://dx.doi.org/10.1177/014556139707601010.

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Rhinophyma is an acne rosacea which primarily affects the midface of elderly men, and causes disfigurement as well as obstruction. There are numerous ways of treating this condition and, in our institution, a CO2 laser is the treatment of choice.

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44

Zouboulis, Christos C., Síona Ní Raghallaigh, Gerd Schmitz, and Frank C. Powell. "The Pro-Differentiation Effect of Doxycycline on Human SZ95 Sebocytes." Dermatology 237, no. 5 (October 22, 2020): 792–96. http://dx.doi.org/10.1159/000510885.

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<b><i>Background:</i></b> Despite their widespread clinical use in both acne vulgaris and rosacea, the effects of tetracyclines on sebocytes have not been investigated until now. Sebaceous glands are central to the pathogenesis of acne and may be important in the development of rosacea. <b><i>Objective:</i></b> The aim of this study was to assess the effects of doxycycline on the immortalized SZ95 sebaceous gland cell line as a model for understanding possible effectiveness on the sebaceous glands in vivo. <b><i>Methods:</i></b> The effects of doxycycline on SZ95 sebocyte numbers, viability, and lipid content as well as its effects on the mRNA levels of peroxisome proliferator-activated receptors α and γ, in comparison to the peroxisome proliferator-activated receptor γ agonist troglitazone, were investigated. <b><i>Results:</i></b> Doxycycline reduced the cell number and increased the lipid content of SZ95 sebocytes in vitro after 2 days of treatment. These doxycycline effects may be explained by an upregulation of peroxisome proliferator-activated receptor γ mRNA levels at 12 and 24 h, whereas troglitazone already upregulated peroxisome proliferator-activated receptor γ levels after 6 h. Both compounds did not influence peroxisome proliferator-activated receptor α mRNA levels. <b><i>Conclusion:</i></b> These new findings illustrate a previously unknown effect of doxycycline on sebocytes, which may be relevant to their modulation of disorders of the pilosebaceous unit, such as acne vulgaris and rosacea.

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45

Negi, Nalini, Sumir Kumar, Sourabh Kosey, and Vir Vikram Sharma. "Evaluation of Prescription Pattern and Quality of life in Acne in Tertiary Care Hospital in North Indian population." Research in Pharmacy and Health Sciences 3, no. 4 (November 15, 2017): 392–400. http://dx.doi.org/10.32463/rphs.2017.v03i04.24.

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Objective: The aim of this study was to evaluate the prescription pattern and Quality of Life of patients and severity of the disease by using Cardiff Acne Disability Index and Global Acne Grading System score respectively. Methods: A cross-sectional study was conducted in North India with 150 samples of patients included into the study. The prescription pattern comprehends the information about the prescribed drugs and also their dosing pattern for different indications that are currently being used in clinical practice. The prescription pattern varies according to the severity of the disease. Results: The cases in the study diagnosed were mostly of acne vulgaris (96.7%), followed by acne conglobata (1.3%), acne rosaceae (1.3%) and acne fulminans (0.7%). Conclusion: It was noted that oral Isotretinoin was the drug of choice for the treatment of moderate and severe forms and antibiotics included into the therapy were minocycline, clindamycin, azithromycin and erythromycin for mild and severe forms. There was not a strong degree of association between therapy and improvement in Cardiff Acne Disability Index and Global Acne Grading System but by observing overall Cardiff Acne Disability Index improvement it can be estimated that the prescription practice used for therapy enhances Quality of Life of the patient.

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46

&NA;. "Topical permethrin may be useful for acne rosacea." Inpharma Weekly &NA;, no. 1009 (October 1995): 15. http://dx.doi.org/10.2165/00128413-199510090-00036.

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47

Erel, A. "Helicobacter pylori seroprevalence in patients with acne rosacea." Journal of the European Academy of Dermatology and Venereology 5, no. 1 (October 1995): S151. http://dx.doi.org/10.1016/0926-9959(95)96388-o.

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48

SCHNEIDER, MARY ELLEN. "Minimize Side Effects From Treatment of Acne, Rosacea." Family Practice News 39, no. 5 (March 2009): 16. http://dx.doi.org/10.1016/s0300-7073(09)70174-4.

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49

Rosamilia, Lorraine. "Over-the-counter treatments for acne and rosacea." Seminars in Cutaneous Medicine and Surgery 35, no. 2 (June 2016): 87–95. http://dx.doi.org/10.12788/j.sder.2016.026.

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50

Elewski, Boni E. "A novel treatment for acne vulgaris and rosacea." Journal of the European Academy of Dermatology and Venereology 14, no. 5 (September 2000): 423–24. http://dx.doi.org/10.1046/j.1468-3083.2000.00086-2.x.

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