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Journal articles on the topic 'Acridine(amino-9 chloro-6 methoxy-2)'

Author: Grafiati

Published: 4 June 2021

Last updated: 7 February 2022

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1

Busto, Natalia, Begoña García, José M. Leal, et al. "ACMA (9-amino-6-chloro-2-methoxy acridine) forms three complexes in the presence of DNA." Physical Chemistry Chemical Physics 13, no. 43 (2011): 19534. http://dx.doi.org/10.1039/c1cp22158b.

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2

Constant, J. F., T. R. O'Connor, J. Lhomme, and J. Laval. "9-[(10-(aden-9-yl)-4,8-diazadecyl)amino]-6-chloro-2-methoxy-acridine incises DNA at apurinic sites." Nucleic Acids Research 16, no. 6 (1988): 2691–703. http://dx.doi.org/10.1093/nar/16.6.2691.

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3

Aly, Enayat I., and Ashraf H. Abadi. "Synthesis and antitubercular activity of 6-chloro (unsubstituted)-2-methoxy-9-substituted acridine derivatives." Archives of Pharmacal Research 27, no. 7 (2004): 713–19. http://dx.doi.org/10.1007/bf02980137.

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4

Lisboa, Thaís, Daiana Silva, Sâmia Duarte, et al. "Toxicity and Antitumor Activity of a Thiophene–Acridine Hybrid." Molecules 25, no. 1 (2019): 64. http://dx.doi.org/10.3390/molecules25010064.

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The antitumor effects of thiophene and acridine compounds have been described; however, the clinical usefulness of these compounds is limited due to the risk of high toxicity and drug resistance. The strategy of molecular hybridization presents the opportunity to develop new drugs which may display better target affinity and less serious side effects. Herein, 2-((6-Chloro-2-methoxy-acridin-9-yl)amino)-5,6,7,8-tetrahydro-4H-cyclohepta[b]-thiophene-3-carbonitrile (ACS03), a hybrid thiophene–acridine compound with antileishmanial activity, was tested for toxicity and antitumor activity. The toxic

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5

Jayat-Vignoles, Chantal, Marie-H�l�ne Ratinaud, and Raymond Julien. "3-Amino-6-methoxy-9-(2-hydroxyethylamino) acridine: A new fluorescent dye to detect mycoplasma contamination in cell cultures." Cytotechnology 4, no. 2 (1990): 191–94. http://dx.doi.org/10.1007/bf00365100.

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6

Zhang, Wei, Bin Zhang, Wei Zhang, et al. "Synthesis and antiproliferative activity of 9-benzylamino-6-chloro-2-methoxy-acridine derivatives as potent DNA-binding ligands and topoisomerase II inhibitors." European Journal of Medicinal Chemistry 116 (June 2016): 59–70. http://dx.doi.org/10.1016/j.ejmech.2016.03.066.

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7

Matthijs, Hans C. P., Jan Maarten Van Steenbergen, and Ruud Kraayenhof. "Studies on 9-amino-6-chloro-2-methoxy acridine fluorescence quenching and enhancement in relation to energy transduction in spheroplasts and intact cells of the cyanobacterium Plectonema boryanum." Photosynthesis Research 7, no. 1 (1985): 59–67. http://dx.doi.org/10.1007/bf00032922.

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8

Golcs, Ádám, Panna Vezse, Bálint Árpád Ádám, Péter Huszthy, and Tünde Tóth. "Comparison in practical applications of crown ether sensor molecules containing an acridone or an acridine unit – a study on protonation and complex formation." Journal of Inclusion Phenomena and Macrocyclic Chemistry 101, no. 1-2 (2021): 63–75. http://dx.doi.org/10.1007/s10847-021-01086-2.

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AbstractCrown ethers containing an acridone or an acridine unit are successfully applied opto- and electrochemical cation sensors. The heteroaromatic unit of these macrocycles can be in different forms during the applications, which have a strong influence on the sensing behavior. Moreover, in the case of acridono-macrocycles a prototropic equilibrium takes place upon complexation, which is effected by the physicochemical characteristics. A Pb2+-selective acridono-18-crown-6 ether and its 9-phenylacridino-analogue were used as model compounds for comparing the different forms of the heterocycl

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9

Di Giorgio, Carole, Florence Delmas, Nathalie Filloux, et al. "In Vitro Activities of 7-Substituted 9-Chloro and 9-Amino-2-Methoxyacridines and Their Bis- and Tetra-Acridine Complexes against Leishmania infantum." Antimicrobial Agents and Chemotherapy 47, no. 1 (2003): 174–80. http://dx.doi.org/10.1128/aac.47.1.174-180.2003.

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ABSTRACT 9-Chloro and 9-amino-2-methoxyacridines bearing different substituents in position 7, as well as their corresponding unsubstituted dimeric and tetrameric complexes, were investigated for in vitro antiproliferative properties against Leishmania infantum compared to toxicity towards human monocytes. The results clearly confirmed that several compounds of the 2-methoxyacridine series, together with their corresponding dimeric and tetrameric derivatives, had strong in vitro antiparasitic properties. Antileishmanial activity was shown to depend on the nature of both 7- and 9-substituted gr

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10

Kitchen, S. E., Yuehhwa Wang, A. L. Baumstark, W. D. Wilson, and David W. Boykin. "The intercalation of 6-chloro-2-substituted-9-[[3-(dimethylamino)propyl]amino]acridines with DNA." Journal of Medicinal Chemistry 28, no. 7 (1985): 940–44. http://dx.doi.org/10.1021/jm00145a016.

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11

Bernát, Juraj, Eva Balentová, Pavol Kristian, et al. "Methylation of Acridin-9-ylthioureas. Structure, Fluorescence and Biological Properties of Products." Collection of Czechoslovak Chemical Communications 69, no. 4 (2004): 833–49. http://dx.doi.org/10.1135/cccc20040833.

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The structure, fluorescence, biological properties and S(N)-methylation reactions of ten 1,1-alkyl/aryl-disubstituted 3-(acridin-9-yl)thioureas 4 have been studied. Various reaction conditions allowed to obtain corresponding S-methyl 5 and S,N-dimethyl derivatives 6 in good yields. Structure and stereochemistry of the synthesized products are demonstrated by ab initio quantum chemical calculations and NMR techniques including PDQF-COSY, selective INEPT and NOE-difference experiments. Remarkable upfield 13C shifts of resonance signals of carbons C-4a, C-10a adjacent to acridine N-10 are charact

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12

Abdelhamid, Antar A., Shaaban K. Mohamed, and Jim Simpson. "Crystal structure of 9-(3-bromo-5-chloro-2-hydroxyphenyl)-10-(2-hydroxyethyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione." Acta Crystallographica Section E Structure Reports Online 70, no. 8 (2014): 44–47. http://dx.doi.org/10.1107/s1600536814009556.

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The title compound C25H29BrClNO4, comprises a 3,3,6,6-tetramethyltetrahydroacridine-1,8-dione ring system that carries a hydroxyethyl substituent on the acridine N atom and a 3-bromo-5-chloro-2-hydroxyphenyl ring on the central methine C atom of the dihydropyridine ring. The benzene ring is inclined to the acridine ring system at an angle of 89.84 (6)° and this conformation is stabilized by an intramolecular O—H...O hydrogen bond between the hydroxy substituent on the benzene ring and one of the carbonyl groups of the acridinedione unit. In the crystal, O—H...O, C—H...O and C—H...Br hydrogen b

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13

Česnek, Michal, Michal Hocek, and Antonín Holý. "Synthesis of Acyclic Nucleotide Analogues Derived from 2-Amino-6-C-substituted Purines via Cross-Coupling Reactions of 2-Amino-9-{2-[(diisopropoxyphosphoryl)methoxy]ethyl}-6-halopurines with Diverse Organometallic Reagents." Collection of Czechoslovak Chemical Communications 65, no. 8 (2000): 1357–73. http://dx.doi.org/10.1135/cccc20001357.

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Cross-coupling reactions of 2-amino-6-chloro-9-{2-[(diisopropoxyphosphoryl)methoxy]ethyl}purine (1) and 2-amino-9-{2-[(diisopropoxyphosphoryl)methoxy]ethyl}-6-iodopurine (2) with diverse types of organometallic reagents have been studied. Arylboronic acids reacted with 1 to give the corresponding 2-amino-6-arylpurines 3a-3d in good yields. Analogously, trialkylaluminium reagents were used for the preparation of 6-alkyl-2-aminopurines 3k and 3l from 1. Hetarylzinc halides and hetarylstannanes required the use of 2-amino-6-iodopurine 2 to give the corresponding 2-amino-6-hetarylpurines 3e-3j in

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14

Roggen, Heidi, Lars Bohlin, Robert Burman, et al. "2-Substituted agelasine analogs: Synthesis and biological activity, and structure and reactivity of synthetic intermediates." Pure and Applied Chemistry 83, no. 3 (2011): 645–53. http://dx.doi.org/10.1351/pac-con-10-09-25.

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2-Substituted N-methoxy-9-methyl-9H-purin-6-amines were synthesized either from their corresponding 6-chloro-9-methyl-9H-purines or 2-chloro-N-methoxy-9-methyl-9H-purin-6-amine. Great diversity in the amino/imino tautomeric ratios was observed and calculated based on 1H NMR. The tautomers were identified by 1D and 2D 1H, 13C, and 15N NMR techniques, and showed significant variation both in 13C and 15N shift values. Comparison of the tautomeric ratios with Hammett F values revealed that as the field/inductive withdrawing abilities of the 2-substituent increased, the ratio of amino:imino tautome

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15

Jin, Yibao, Xudong Luan, Hongxia Liu, et al. "Pharmacokinetics and metabolite identification of a novel VEGFR-2 and Src dual inhibitor 6-chloro-2-methoxy-N-(2-methoxybenzyl) acridin-9-amine in rats by liquid chromatography tandem mass spectrometry." Talanta 89 (January 2012): 70–76. http://dx.doi.org/10.1016/j.talanta.2011.11.061.

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16

Holý, Antonín, Ivan Votruba, Eva Tloušťová, and Milena Masojídková. "Synthesis and Cytostatic Activity of N-[2-(Phosphonomethoxy)alkyl] Derivatives of N6-Substituted Adenines, 2,6-Diaminopurines and Related Compounds." Collection of Czechoslovak Chemical Communications 66, no. 10 (2001): 1545–92. http://dx.doi.org/10.1135/cccc20011545.

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N6-Substituted adenine and 2,6-diaminopurine derivatives of 9-[2-(phosphonomethoxy)- ethyl] (PME), 9-[(R)-2-(phosphonomethoxy)propyl] [(R)-PMP] and enantiomeric (S)-PMP series were synthesized by reactions of primary or secondary amines with 6-chloro-9-{[2-(diisopropoxyphosphoryl)methoxy]alkyl}purines (26-28) or 2-amino-6-chloro-9-{[2-(diisopropoxy- phosphoryl)methoxy]alkyl}purines (29-31) followed by treatment of the diester intermediates32with bromo(trimethyl)silane and hydrolysis. Diesters32were also obtained by reaction ofN6-substituted purines with synthons23-25bearing diisopropoxyphospho

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17

Ritter, Ronald L., Thomas C. Harris, and Lisa M. Kaufman. "Chlorsulfuron and Metsulfuron Residues on Double-Cropped Soybeans (Glycine max)." Weed Technology 2, no. 1 (1988): 49–52. http://dx.doi.org/10.1017/s0890037x00030074.

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In field experiments in 1981, 36 g ai/ha of chlorsulfuron {2-chloro-N-[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino] carbonyl] benzenesulfonamide} applied to winter wheat (Triticum aestivumL. ‘Arthur’) in early spring reduced seed yield in conventional and no-till plantings of double-cropped soybeans [Glycine max(L.) ‘Essex’]. From 1982 to 1984, three rates of chlorsulfuron (9, 18, and 36 g/ha) were applied at three different times (preemergence, early winter, and early spring) to study their residual effects on double-cropped soybeans. Chlorsulfuron at 36 g/ha applied preemergence or early s

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18

Smetanin, Nikolay, Sofia Tokarieva, Svetlana Varenichenko, Oleg Farat, and Victor Markov. "IN SILICO PREDICTION AND MOLECULAR DOCKING STUDIES OF BIOLOGICAL ACTIVITY OF HYDROACRIDINE (QUINOLINE) DERIVATIVES." Ukrainian Chemistry Journal 87, no. 5 (2021): 38–52. http://dx.doi.org/10.33609/2708-129x.87.05.2021.38-52.

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To find biological activity among easily available 2-[(4S,4’S/4R,4’R)-2’,5’-dioxo-2,3,5,6,7,8-hexahydro-1H-spiro[acridine-4,3’-pyrrolidin]-4’-yl]-N-aryl-acetamide, (4S/4R)-4-[(3R/3S)-1-(2-aryl)-2,5-dioxopyrrolidin-3-yl]-1,2,3,4,5,6,7,8-octahydroacridine-4-carbonitrile, (3S/4R)-3-[(3R/4S)-9-chloroacridine(quinoline)-4-yl]-1-N-aryl)pyrrolidine-2,5-diones. Methods: Organic synthesis, spectral methods, and molecular docking. We investigated by molecular docking the potential biological activity of previously synthesized compounds containing acridine and pyrrolidine-2,5-diones fragments in their st

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19

PANDEY, SWAROOP KUMAR, SUBHASISH BISWAS, SARIKA GUNJAN, et al. "Pyrrolidine-Acridine hybrid in Artemisinin-based combination: a pharmacodynamic study." Parasitology 143, no. 11 (2016): 1421–32. http://dx.doi.org/10.1017/s0031182016000937.

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SUMMARYAiming to develop new artemisinin-based combination therapy (ACT) for malaria, antimalarial effect of a new series of pyrrolidine-acridine hybrid in combination with artemisinin derivatives was investigated. Synthesis, antimalarial and cytotoxic evaluation of a series of hybrid of 2-(3-(substitutedbenzyl)pyrrolidin-1-yl)alkanamines and acridine were performed and mode of action of the lead compound was investigated. In vivo pharmacodynamic properties (parasite clearance time, parasite reduction ratio, dose and regimen determination) against multidrug resistant (MDR) rodent malaria paras

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20

Sondhi, Sham, Gurudas Bhattacharjee, Rafid Jameel, et al. "Antiinflammatory, analgesic and kinase inhibition activities of some acridine derivatives." Open Chemistry 2, no. 1 (2004): 1–15. http://dx.doi.org/10.2478/bf02476181.

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Abstract9-Chloro-2,4-(un)substituted acridines (1) on condensation with sulpha- diazine, sulphathiazole, and sulphaacetamide gave condensation products 3a-h. 3-Aryl-4-phenyl-2-imino-4-thiazolines (4) on condensation with 9-chloro-2,4-(un)substituted acridines (1) gave condensation products 5a–5o. Both 3a–3h and 5a–5o were purified by crystallization or by chromatography. Structures assigned to 3a–3h and 5a–5o are supported by correct spectral data. Antiinflammatory and analgesic activity screening of 3a, 3e, 3f and 5a–5c, 5e, 5g, 5i, 5m, 5n were carried out using carrageenin induced paw oedema

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21

Naga Raju, Gollapalli. "GREEN SYNTHESIS, CHARACTERIZATION, AND ANTHELMINTHIC ACTIVITY OF NEWER QUINOLINE DERIVATIVES CONTAINING ACRIDINE MOIETY." Asian Journal of Pharmaceutical and Clinical Research 10, no. 9 (2017): 377. http://dx.doi.org/10.22159/ajpcr.2017.v10i9.17226.

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Objectives: Synthesis of newer 3,4,6,7-tetrahydro-3,3,6,6-tetramethyl-9-(2-chloro-6-substituted-quinolin-3-yl)-acridine-1,8(2H,5H,9H,10H)-diones were synthesized by reacting 5,5-dimethylcyclohexane-1,3-dione with substituted 2-chloro-quinoline-3-carbaldehyde in presence of ammonium acetate.Methods: Synthesis was carried out by microwave irradiation method and the synthesized compounds have been characterized using elemental analysis, FT-IR, 1H NMR, and 13C NMR spectroscopy and further supported by mass spectroscopy. Purity of all the compounds has been checked on thin layer chromatographic pla

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22

Maresca, Luciana, Concetta Pacifico, Maria C. Pappadopoli, and Giovanni Natile. "Endocyclic versus exocyclic N-coordination to platinum(II) of some nitro-9-[(2-dialkylaminoethyl)amino]acridines." Inorganica Chimica Acta 304, no. 2 (2000): 274–82. http://dx.doi.org/10.1016/s0020-1693(00)00100-6.

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23

Danihel, Ivan, Kalevi Pihlaja, Ján Imrich, et al. "Configuration and Conformation Study of S-Allyl O-Methyl N-(2- and 4-Substituted Acridin-9-yl)thiocarbonimidates in Relation to Their [3,3] Sigmatropic Rearrangement." Collection of Czechoslovak Chemical Communications 63, no. 3 (1998): 387–93. http://dx.doi.org/10.1135/cccc19980387.

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Configuration and conformations of S-allyl O-methyl N-(2- and 4-substituted acridin-9-yl)thiocarbonimidates were studied by means of NMR spectroscopy, dipole moments and quantum chemical calculations. The E configuration was proved for the unsubstituted and 2-chloro derivatives from the NOE-difference spectra. Experimental values of dipole moments were related to those obtained from vector addition. Quantum chemical calculations pointed to the chair conformation of these compounds in transition state for above-mentioned rearrangement.

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24

Biniak, Barbara M., and Richard J. Aldrich. "Reducing Velvetleaf (Abutilon theophrasti) and Giant Foxtail (Setaria faberi) Seed Production with Simulated-Roller Herbicide Applications." Weed Science 34, no. 2 (1986): 256–59. http://dx.doi.org/10.1017/s0043174500066789.

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The potential of preventing seed production and reducing seed viability of weeds that commonly grow taller than soybeans [Glycine max(L.) Merr. ‘Williams 82’] was evaluated. Chlorflurenol (2-chloro-9-hydroxy-9H-fluorene-9-carboxylic acid), chlorsulfuron {2-chloro-N-[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino] carbonyl] benzenesulfonamide}, and glyphosate [N-(phosphonomethyl)glycine] were evaluated against sparse stands of velvetleaf (Abutilon theophrastiMedik. # ABUTH) and giant foxtail (Setaria faberiHerrm. # SETFA) growing in soybeans. Simulated-roller applications of all three herbicides

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25

Bharathi, A., Selvaraj Mohana Roopan, Abdul Abdul Rahuman, and Govindasamy Rajakumar. "In VitroLarvicidal and Antioxidant Activity of Dihydrophenanthroline-3-carbonitriles." BioMed Research International 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/915797.

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Many naturally occurring and synthetic compounds containing dihydrocyanopyridine and cyanopyran moiety show pharmacological properties. The aim of this study is to investigate the larvicidal and antioxidant potential of dihydrophenanthroline-3-carbonitrile derivatives4a–f. A novel series of 2-amino-10-chloro-4,12-diphenyl-1,4,5,6-tetrahydrobenzo[j][1,7]phenanthroline-3-carbonitrile derivatives were synthesized by reacting different substituted acridine chalcones through Michel addition. The compounds were synthesized in excellent yields and the structures were corroborated on the basis of FT-I

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26

Sharma, Anamika, Sonika Jain, Reenu Sirohi, and D. Kishore. "Synthesis of [2′-(N-Ethylamino)-5′-Alkyl]phenyl-5,6,7,8-Tetrahydroacridine-9-Carboxy-2-Sulfone Derivatives by the Proton-Catalyzed Rearrangement of Corresponding Sulfonamides." Organic Chemistry International 2011 (January 11, 2011): 1–5. http://dx.doi.org/10.1155/2011/614627.

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Synthesis of a new series of heteroaryl sulfones 6(a–f) in which the heteroaryl part is represented by acridine derivatives has been developed and reported here. The key step of this transformation involves the proton-catalyzed rearrangement of the sulphonamide derivatives 5(a–f) to the corresponding sulfones 6(a–f).

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27

Jindřich, Jindřich, Hana Dvořáková, and Antonín Holý. "Synthesis of Isomeric N-(3-Fluoro-2-hydroxypropyl) and N-(2-Fluoro-3-hydroxypropyl) Derivatives of Purine and Pyrimidine Bases." Collection of Czechoslovak Chemical Communications 57, no. 7 (1992): 1466–82. http://dx.doi.org/10.1135/cccc19921466.

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Reaction of fluoromethyloxirane (III) with heterocyclic bases in the presence of potassium carbonate afforded N-(3-fluoro-2-hydroxypropyl) derivatives of adenine (VI), 3-deazaadenine (VII), 2-amino-6-chloropurine (XII), 6-nitro-1-deazapurine (IX), 4-methoxy-2-pyrimidone (XVIII) and its 5-methyl derivative (XIX). Acid hydrolysis of compounds XII, XVIII, and XIX gave 9-(3-fluoro-2-hydroxypropyl)guanine (XIII), 1-(3-fluoro-2-hydroxypropyl)uracil (XX) and -thymine (XXI). The intermediates XVIII and XIX were ammonolyzed to give 1-(3-fluoro-2-hydroxypropyl)cytosine (XXII) and -5-methylcytosine (XXII

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28

Donald, William W. "Effect of Soil-Applied Chlorsulfuron on Canada Thistle (Cirsium arvense) Root and Root Bud Growth." Weed Technology 1, no. 2 (1987): 154–61. http://dx.doi.org/10.1017/s0890037x00029365.

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Chlorsulfuron [2-chloro-N-[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)-amino] carbonyl] benzenesulfonamide], applied at 9 to 560 g ai/ha to the soil surface, stopped shoot elongation of well established Canada thistle [Cirsium arvense(L.) Scop. #4CIRAR] plants in the greenhouse. Root fresh weight decreased progressively as chlorsulfuron rate was increased when measured 1 month after treatment. In contrast, the number of visible root buds plus secondary shoots increased 1.9- to 2.3-fold between 9 and 67 g/ha chlorsulfuron 1 month after soil surface treatment. Despite more numerous root buds, the n

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29

CHOLODY, W. M., S. MARTELLI, and P. V. GARIBOLDI. "ChemInform Abstract: Substituted 1,4-Diazepino(5,6,7-kl)acridines as Unexpected Side Products in Reaction of 2-(Dialkylamino)ethylamine with 1-Chloro-7- methoxy-4-nitro-9-phenoxyacridine." ChemInform 23, no. 31 (2010): no. http://dx.doi.org/10.1002/chin.199231207.

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30

Almeida, Marcel L., Douglas C. F. Viana, Valécia C. M. da Costa, et al. "Synthesis, Antitumor Activity and Molecular Docking Studies on Seven Novel Thiazacridine Derivatives." Combinatorial Chemistry & High Throughput Screening 23, no. 5 (2020): 359–68. http://dx.doi.org/10.2174/1386207323666200319105239.

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Aim and Objective: In the last decades, cancer has become a major problem in public health all around the globe. Chimeric chemical structures have been established as an important trend on medicinal chemistry in the last years. Thiazacridines are hybrid molecules composed of a thiazolidine and acridine nucleus, both pharmacophores that act on important biological targets for cancer. By the fact it is a serious disease, seven new 3-acridin-9-ylmethyl-thiazolidine-2,4-dione derivatives were synthesized, characterized, analyzed by computer simulation and tested in tumor cells. In order to find ou

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31

Caruso, Joseph A., Patricia A. Mathieu, and John J. Reiners. "Sphingomyelins suppress the targeted disruption of lysosomes/endosomes by the photosensitizer NPe6 during photodynamic therapy." Biochemical Journal 392, no. 2 (2005): 325–34. http://dx.doi.org/10.1042/bj20050313.

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Recent studies have described a biochemical pathway whereby lysosome disruption and the released proteases initiate the intrinsic apoptotic pathway. Irradiation of murine hepatoma 1c1c7 cells preloaded with the lysosomal photosensitizer NPe6 (N-aspartyl chlorin e6) caused a rapid loss of Acridine Orange staining of acidic organelles, release of cathepsin D from late endosomes/lysosomes and the activation of procaspase-3. Pretreatment of NPe6-loaded cultures with 10–50 μM 3-O-MeSM (3-O-methylsphingomyelin) caused a concentration-dependent suppression of apoptosis following irradiation. This sup

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32

Zeng, Zijian, and Steven C. Zimmerman. "Convenient synthesis of 9-alkyl and 9-arylacridines from [2 - (trimethylsilyl) ethoxy] methyl (sem) protected acridone." Tetrahedron Letters 29, no. 40 (1988): 5123–24. http://dx.doi.org/10.1016/s0040-4039(00)80696-6.

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33

Healy, PC, C. Pakawatchai, and AH White. "Structural Characterization of a [Cl3CuL]- (L=Nitrogen Base) Species. A Novel Coordination Environment for Copper(II)." Australian Journal of Chemistry 38, no. 5 (1985): 669. http://dx.doi.org/10.1071/ch9850669.

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The crystal structure of [C13H10N] [CuCl3(C13H9N)].H2O(C13H9N ≡ acridine ) has been determined by single-crystal X-ray diffraction methods at 295 K, being refined by least squares to a residual of 0.037 for 1942 independent 'observed' reflections. Crystals are triclinic, Pī , a 16.27(2), b 10.080(8), c 7.236(5) Ǻ, α 88.85(6), β 82.68(8), γ 81.12(9)°, Z 2. The metal atom stereochemistry is unusual, being of pseudo-m symmetry; one of the chlorine atoms is coplanar with the copper and the acridine [Cu- Cl 2.237(2) Ǻ, N-Cu- Cl 143.5(1)°], with the other two disposed to either side of that plane [C

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34

Hafez, Hend N., and Abdel-Rhman B. A. El-Gazzar. "Synthesis and evaluation of antitumor activity of new 4-substituted thieno[3,2-d]pyrimidine and thienotriazolopyrimidine derivatives." Acta Pharmaceutica 67, no. 4 (2017): 527–42. http://dx.doi.org/10.1515/acph-2017-0039.

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Abstract 3-Methyl-6-phenyl-2-thioxo-2,3-dihydrothieno[3,2-d]pyrimidin- 4(1H)-one (2), on treatment with phosphorous oxychoride, affored 4-chloro-3-methyl-6-phenyl -thieno[3,2-d]pyrimidine- 2(3H)-thione (3). A series of novel 6-phenyl-thieno[3,2-d]pyrimidine derivatives 4-9 bearing different functional groups were synthesized via treatment of compound 3 with different reagents. On the other hand, compound 2 was used to synthesize ethyl-[(3-methyl-6-phenyl-2-thioxo-2,3-dihydrothieno[ 3,2-d]pyrimidin-4-yl)-oxy]acetate (10), 2-hydrazinyl- -3-methyl-6-phenyl-thieno[3,2-d]pyrimidin-4(3H)-one (11), 3

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Berrington, Danielle, and Namrita Lall. "Anticancer Activity of Certain Herbs and Spices on the Cervical Epithelial Carcinoma (HeLa) Cell Line." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–11. http://dx.doi.org/10.1155/2012/564927.

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Acetone extracts of selected plant species were evaluated for theirin vitrocytotoxicity against a noncancerous African green monkey kidney (Vero) cell line and an adenocarcinoma cervical cancer (HeLa) cell line. The plants studied wereOriganum vulgareL. (Oregano),Rosmarinus officinalisL. (Upright and ground cove rosemary),Lavandula spicaL. (Lavender),Laurus nobilisL. (Bay leaf),Thymus vulgarisL. (Thyme),Lavandula x intermediaL. (Margaret Roberts Lavender),Petroselinum crispumMill. (Curly leaved parsley),Foeniculum vulgareMill. (Fennel), andCapsicum annuumL. (Paprika). Antioxidant activity was

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Ghosh, Subhajit, Tapas Das, Shishu K. Suman, Chandan Kumar, Haladhar D. Sarma, and Ashutosh Dash. "Targeted Tumor Therapy with Radiolabeled DNA Intercalator: A Possibility? Preclinical Investigations with 177Lu-Acridine." BioMed Research International 2020 (July 25, 2020): 1–13. http://dx.doi.org/10.1155/2020/9514357.

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Objective. A DNA intercalating agent reversibly stacks between the adjacent base pairs of DNA and thus is expected to exhibit preferential localization in the tumorous lesions as tumors are associated with enhanced DNA replication. Therefore, radiolabeled DNA intercalators are supposed to have potential to be used in targeted tumor therapy. Working in this direction, an attempt was made to radiolabel 9-aminoacridine, a DNA intercalator, with 177Lu, one of the most useful therapeutic radionuclides, and study the potential of 177Lu-acridine in targeted tumor therapy. Experiments. 9-Aminoacridine

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Liebl, Rex, and A. Douglas Worsham. "Effect of Chlorsulfuron on the Movement and Fate of Diclofop in Italian Ryegrass (Lolium multiflorum) and Wheat (Triticum aestivum)." Weed Science 35, no. 5 (1987): 623–28. http://dx.doi.org/10.1017/s0043174500060689.

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The basis for chlorsulfuron {2-chloro-N-[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino] caronyl] benzenesulfonamide} antagonism of diclofop {(±)-2-[4-(2,4-dichlorophenoxy)phenoxy] propanoic acid} was investigated in Italian ryegrass [Lolium multiflorum(Lam.) # LOLMU] and wheat (Triticum aestivumL. ‘McNair 1813′). Chlorsulfuron did not affect the chemical stability or volatility of diclofop in spray mixtures over the time and concentration ranges evaluated. Addition of chlorsulfuron (0.11 μg/μl) to a diclofop (2.0 μg/μl) foliar-applied spotting solution did not affect the absorption, translocat

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Lee, Sullim, Hiroyuki Morita, and Yasuhiro Tezuka. "Preferentially Cytotoxic Constituents of Andrographis paniculata and their Preferential Cytotoxicity against Human Pancreatic Cancer Cell Lines." Natural Product Communications 10, no. 7 (2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000704.

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In the course of our search for anticancer agents based on a novel anti-austerity strategy, we found that the 70% EtOH extract of the crude drug Andrographis Herba (aerial parts of Andrographis paniculata), used in Japanese Kampo medicines, killed PANC-1 human pancreatic cancer cells preferentially in nutrient-deprived medium (NDM). Phytochemical investigation of the 70% EtOH extract led to the isolation of 21 known compounds consisting of six labdane-type diterpenes (11, 15, 17-19, 21), six flavones (5, 7, 10, 12, 14, 20), three flavanones (2, 6, 16), two sterols (3, 8), a fatty acid (1), a p

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Reisch, Johannes, and Reza A. Salehi-Artimani. "Acetylenchemie 2. Mitt.: Sigmatrope Umlagerungen bei der phasentransferkatalysierten Umsetzung von 9(10H)-Acridinon mit 3-Chlor-3-methylbut-1-in." Monatshefte f�r Chemie Chemical Monthly 116, no. 8-9 (1985): 1099–102. http://dx.doi.org/10.1007/bf00809200.

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40

Dearmond, Patrick D., Graham M. West, Victor Anbalagan, Michael J. Campa, Edward F. Patz, and Michael C. Fitzgerald. "Discovery of Novel Cyclophilin A Ligands Using an H/D Exchange– and Mass Spectrometry–Based Strategy." Journal of Biomolecular Screening 15, no. 9 (2010): 1051–62. http://dx.doi.org/10.1177/1087057110382775.

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Cyclophilin A (CypA) is an overexpressed protein in lung cancer tumors and as a result is a potential therapeutic and diagnostic target. Described here is use of an H/D exchange– and a matrix assisted laser desorption/ionization (MALDI) mass spectrometry–based assay, termed single-point SUPREX (Stability of Unpurified Proteins from Rates of H/D Exchange), to screen 2 chemical libraries, including the 1280-compound LOPAC library and the 9600-compound DIVERSet library, for binding to CypA. This work represents the first application of single-point SUPREX using a pooled ligand approach, which is

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41

Cholody, Wieslaw M., Sante Martelli, and Pierluigi V. Gariboldi. "Substituted 1,4-diazepino[5,6,7-kl]acridines as unexpected side products in reaction of 2-(dialkylamino)ethylamine with 1-chloro-7-methyoxy-4-nitro-9-phenoxyacridine." Journal of Heterocyclic Chemistry 29, no. 1 (1992): 161–65. http://dx.doi.org/10.1002/jhet.5570290129.

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Strekowski, Lucjan, Jianguo Zhang, Jaroslaw Saczewski, and Ewa Wolinska. "Acridine Synthesis by the Reaction of 2-(Perfluoroalkyl)aniline with ortho-Alkyl-Substituted Aromatic Grignard Reagent: Mechanistic Studies." Australian Journal of Chemistry 68, no. 2 (2015): 196. http://dx.doi.org/10.1071/ch14401.

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The reaction of 2-(perfluoroethyl)aniline and its higher perfluoroalkyl analogues with an arylmagnesium bromide substituted with a methyl or ethyl group at the ortho position furnishes an acridine containing a shorter perfluoroalkyl group at the 9-position and devoid of the methyl or ethyl group of the Grignard reagent. Yields are in the range of 46–93 %. The intermediary of a substituted aza-ortho-xylylene has been postulated for related transformations in the literature previously, but this intermediate product has never been isolated. As part of this work, the labile product E-27 (half-life

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43

Pichla, Monika, Łukasz Pulaski, Katarzyna Dominika Kania, et al. "Nitroxide Radical-Containing Redox Nanoparticles Protect Neuroblastoma SH-SY5Y Cells against 6-Hydroxydopamine Toxicity." Oxidative Medicine and Cellular Longevity 2020 (April 24, 2020): 1–19. http://dx.doi.org/10.1155/2020/9260748.

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Parkinson’s disease (PD) patients can benefit from antioxidant supplementation, and new efficient antioxidants are needed. The aim of this study was to evaluate the protective effect of selected nitroxide-containing redox nanoparticles (NRNPs) in a cellular model of PD. Antioxidant properties of NRNPs were studied in cell-free systems by protection of dihydrorhodamine 123 against oxidation by 3-morpholino-sydnonimine and protection of fluorescein against bleaching by 2,2-azobis(2-amidinopropane) hydrochloride and sodium hypochlorite. Model blood-brain barrier penetration was studied using hCME

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Shahriar, Mohammad Shahriar, Mohiuddin Ahmed Bhuiyan, and Md Sohel Rana. "Isolation and identification of different compounds from Citrus assamensis leaf." Journal of Bangladesh Academy of Sciences 44, no. 2 (2021): 85–93. http://dx.doi.org/10.3329/jbas.v44i2.51453.

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Six coumarins, one benzene, one flavone, one acridone, one limonoid, one triterpene and two phytosterol derivatives were isolated from the methanol, ethanol and chloroform leaf extracts of Citrus assamensis. Extensive spectroscopic studies, including high field 1H NMR and 13C NMR analyses, allowed the identification of thirteen known compounds as bergapten (1), umckalin (2), citropten (3), 4-hydroxybenzaldehyde (4), bergamottin (5), β-amyrin (6), umbeliferone (7), scopoletin (8), citrusinol (9), citracridone-III (10), limonin (11), stigmasterol (12), and β-sitosterol (13). The identity of thes

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Rimmer, Elizabeth L., Rosa D Bailey, Timothy W. Hanks, and William T Pennington. "Complexes of Acridine and 9-Chloroacridine with I2: Formation of Unusual I6 Chains through Charge-Transfer Interactions Involving Amphoteric I2." Chemistry 6, no. 22 (2000): 4071–81. http://dx.doi.org/10.1002/1521-3765(20001117)6:22<4071::aid-chem4071>3.0.co;2-#.

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46

Jakob, N. J., R. G. Kleespies, C. A. Tidona, K. Müller, H. R. Gelderblom, and G. Darai. "Comparative analysis of the genome and host range characteristics of two insect iridoviruses: Chilo iridescent virus and a cricket iridovirus isolate." Journal of General Virology 83, no. 2 (2002): 463–70. http://dx.doi.org/10.1099/0022-1317-83-2-463.

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The iridovirus isolate termed cricket iridovirus (CrIV) was isolated in 1996 from Gryllus campestris L. and Acheta domesticus L. (both Orthoptera, Gryllidae). CrIV DNA shows distinct DNA restriction patterns different from those known for Insect iridescent virus type 6 (IIV-6). This observation led to the assumption that CrIV might be a new species within the family Iridoviridae. CrIV can be transmitted perorally to orthopteran species, resulting in specific, fatal diseases. These species include Gryllus bimaculatus L. and the African migratory locust Locusta migratoria migratorioides (Orthopt

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47

Smetanin, N. V., and A. V. Mazepa. "Functionalization of N-arylmaleimides by sp3 C–H bonds of hydroacridines(qinolines)." Voprosy Khimii i Khimicheskoi Tekhnologii, no. 6 (December 2020): 165–70. http://dx.doi.org/10.32434/0321-4095-2020-133-6-165-170.

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The catalyst-free sp3 C–H functionalization of tetrahydroacridine(quinolines) derivatives has been achieved using a Michael-type reaction with N-arylmaleimides. This method enables the facile synthesis of biologically important N-aryl bearing tetrahydroacridine(quinolines) moieties in a single step with high yields. The reaction occurs under non-catalytic conditions by heating of hydroacridines(quinolines) in DMSO within 4 h at 100–1200C. The reaction between starting compounds allows synthesizing (3S/4R)-3-[(3R/4S)-9-chloroacridine(quinoline)-4-yl]-1(-N-aryl)pyrrolidine-2,5-diones with a good

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48

Tangelder, G. J., C. J. Janssens, D. W. Slaaf, M. G. oude Egbrink, and R. S. Reneman. "In vivo differentiation of leukocytes rolling in mesenteric postcapillary venules." American Journal of Physiology-Heart and Circulatory Physiology 268, no. 2 (1995): H909—H915. http://dx.doi.org/10.1152/ajpheart.1995.268.2.h909.

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A method is presented to assess in vivo in transparent tissues the leukocyte subtypes that roll in microvessels. In nine rabbits anesthetized with ketamine-xylazine, leukocyte nuclei were stained in situ with acridine yellow (3 mg/kg i.v. for 5 min). Intravital fluorescence video microscopy in 24 mesenteric venules (17–29 microns, median 21) indicated labeling of all rolling leukocytes. On the basis of the shape of their nucleus, 67–100% (median 89) could be classified unequivocally (13366 cells analyzed, median 77) as polymorphonuclear (PMN, i.e., granulocytes) or monomorphonuclear (lymphocyt

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Sivaraman, Mahalingam, Doraiswamy Muralidharan, and Paramasivan T. Perumal. "Synthesis of novel 9-(1-iodovinyl)acridin-(2H)-one through iodine mediated cascade 6-endo-dig cyclization followed by condensation and 3,3-sigmatropic migration of 2-aminophenyl propynyl oxyenone." Tetrahedron Letters 53, no. 45 (2012): 6039–43. http://dx.doi.org/10.1016/j.tetlet.2012.08.107.

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Maula, Yuliana Musrifatul, Ari Hayati, and Hasan Zayadi. "Identifikasi Serangga Pada Lahan Tanaman Jagung (Zea mays L.) di Unit Pelaksana Teknis Pengembangan Benih Palawija Singosari Kabupaten Malang." BIOSAINTROPIS (BIOSCIENCE-TROPIC) 5, no. 2 (2019): 24–29. http://dx.doi.org/10.33474/e-jbst.v5i2.208.

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Corn is a seasonal plant. Corn is one of the crop commodities that has an important role in agriculture and the economy in Indonesia. Problems that often occur in the cultivation of corn (Zea mays) are such as water availability, land area, weather, disease and pest attacks. Insects are animals which include an important role in the agricultural ecosystem, but not all insects are beneficial for these plants. Insects also consist of several types of Orders, namely the Order of Coleoptera, Order of Diptera, Order of Lepidoptera, Order of Homoptera, Order of Hemiptera, and Order of Thysanoptera.

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