Relevant bibliographies by topics / Acridine Compounds

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Academic literature on the topic 'Acridine Compounds'

Author: Grafiati
Published: 4 June 2021
Last updated: 9 February 2022

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Journal articles on the topic "Acridine Compounds"

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Golcs, Ádám, Panna Vezse, Bálint Árpád Ádám, Péter Huszthy, and Tünde Tóth. "Comparison in practical applications of crown ether sensor molecules containing an acridone or an acridine unit – a study on protonation and complex formation." Journal of Inclusion Phenomena and Macrocyclic Chemistry 101, no. 1-2 (2021): 63–75. http://dx.doi.org/10.1007/s10847-021-01086-2.

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AbstractCrown ethers containing an acridone or an acridine unit are successfully applied opto- and electrochemical cation sensors. The heteroaromatic unit of these macrocycles can be in different forms during the applications, which have a strong influence on the sensing behavior. Moreover, in the case of acridono-macrocycles a prototropic equilibrium takes place upon complexation, which is effected by the physicochemical characteristics. A Pb2+-selective acridono-18-crown-6 ether and its 9-phenylacridino-analogue were used as model compounds for comparing the different forms of the heterocycl
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Othman, Salem, and Maria Kozurkova. "Sulfur Containing Acridine Derivatives in Preclinical Studies with Cancer Cell Lines." Current Medicinal Chemistry 25, no. 17 (2018): 1968–75. http://dx.doi.org/10.2174/0929867324666170414165019.

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Background: The possible use of acridines as anticancer agents was first considered in the 1920´s. Since then, a large number of acridine drugs have been tested as antitumour agents, including compounds containing sulphur on the acridine chromophore. In this review, we will discuss recent studies which have investigated the anticancer activity of this class of acridine derivatives. Methods: We present the results both of our own decade-long research and also of existing research literature into the anticancer activity of acridine derivatives containing sulphur. The evidence of specific tumor-c
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Caffrey, Conor R., Dietmar Steverding, Ryan K. Swenerton, et al. "Bis-Acridines as Lead Antiparasitic Agents: Structure-Activity Analysis of a Discrete Compound Library In Vitro." Antimicrobial Agents and Chemotherapy 51, no. 6 (2007): 2164–72. http://dx.doi.org/10.1128/aac.01418-06.

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ABSTRACT Parasitic diseases are of enormous public health significance in developing countries—a situation compounded by the toxicity of and resistance to many current chemotherapeutics. We investigated a focused library of 18 structurally diverse bis-acridine compounds for in vitro bioactivity against seven protozoan and one helminth parasite species and compared the bioactivities and the cytotoxicities of these compounds toward various mammalian cell lines. Structure-activity relationships demonstrated the influence of both the bis-acridine linker structure and the terminal acridine heterocy
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Gabriel, Iwona. "‘Acridines’ as New Horizons in Antifungal Treatment." Molecules 25, no. 7 (2020): 1480. http://dx.doi.org/10.3390/molecules25071480.

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Frequent fungal infections in immunocompromised patients and mortality due to invasive mycosis are important clinical problems. Opportunistic pathogenic Candida species remain one of the leading causes of systemic mycosis worldwide. The repertoire of antifungal chemotherapeutic agents is very limited. Although new antifungal drugs such as lanosterol 14α-demethylase and β-glucan synthase inhibitors have been introduced into clinical practice, the development of multidrug resistance has become increasingly significant. The urgency to expand the range of therapeutic options for the treatment of f
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Khunnawutmanotham, Nisachon, Watthanachai Jumpathong, Chatchakorn Eurtivong, Nitirat Chimnoi, and Supanna Techasakul. "Synthesis, cytotoxicity evaluation, and molecular modeling studies of 2,N10-substituted acridones as DNA-intercalating agents." Journal of Chemical Research 44, no. 7-8 (2020): 410–25. http://dx.doi.org/10.1177/1747519820902674.

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Acridine-based compounds possess anticancer activities by intercalating to DNA. Although they have chemotherapeutic potential, acridine-based compounds are not used to treat cancer. In this study, 2, N10-acridone derivatives are designed and synthesized based on acridone, a ketone derivative of acridine. Herein, acridone is functionalized with alkyl side chains containing terminal nitrogen-based moieties at the N10-position and substituted at the C2-position. The products are evaluated for in vitro cytotoxicity against four cancer cell lines: Molt-3, HepG2, A549, and HuCCA-1. The derivative be
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Magesh M and Gandhimathi R. "An overview of pharmacological activities of acridine derivatives." International Journal of Research in Pharmaceutical Sciences 11, no. 4 (2020): 6922–31. http://dx.doi.org/10.26452/ijrps.v11i4.3683.

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The derivatives of acridine can be served as a lead molecule of an antibacterial, anti-viral antiprotozoal, anti-viral, antitubercular, anti-fungal, anti-malarial and anti-cancer agents. Even though the usage of acridine becomes limited due to its side effects, so many potent and safe compounds can be derived through molecular modification in the acridine ring. Since the resistance of pathogens and tumour cells has become more common nowadays, it necessitates the search of new drug candidates. Since the treatment and management of Alzheimer's disease is such a complicated and proper drug regim
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Chen, Rui, Lini Huo, Yogini Jaiswal, et al. "Design, Synthesis, Antimicrobial, and Anticancer Activities of Acridine Thiosemicarbazides Derivatives." Molecules 24, no. 11 (2019): 2065. http://dx.doi.org/10.3390/molecules24112065.

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Background: Acridine and thiourea derivatives are important compounds in medicinal chemistry due to their diverse biological properties including anticancer and antimicrobial effects. However, literature reveals some side effects associated with use of acridines. It is suggested that hybrid molecules may reduce the side effects and enhance the beneficial properties due to synergistic activity. The objectives of the present study are to synthesize and evaluate the anticancer and antimicrobial properties of new hybrids of acridine thiosemicarbazides derivatives. Results: The structures of the sy
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Němcová, Irena, Karel Nesměrák, Božena Kafková, and Jan Sejbal. "Physicochemical Properties of 9-(Alkylsulfanyl)- and 9-(Arylsulfanyl)acridine Derivatives and Their Interaction with (2-Hydroxypropyl)cyclodextrins." Collection of Czechoslovak Chemical Communications 71, no. 2 (2006): 179–89. http://dx.doi.org/10.1135/cccc20060179.

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Acid-base properties and aggregations of 9-(alkylsulfanyl)- and 9-(arylsulfanyl)acridine derivatives were studied as a part of systematic study of physicochemical properties of these compounds synthesized as potential drugs. The effect of the (2-hydroxypropyl)cyclodextrins on these properties and their association with the acridines was also followed.
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Lahmy, S., J. M. Salmon, and P. Viallet. "Microspectrofluorometric comparison of benzo(a)pyrene and dibenzo(c,h)acridine metabolism in single living 3T3 fibroblasts." Journal of Histochemistry & Cytochemistry 35, no. 2 (1987): 197–201. http://dx.doi.org/10.1177/35.2.3794313.

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The purpose of this study was to determine if dibenzo(c,h)acridine could be used as a probe for the N-heterocyclic aromatic compound detoxification system. The determination was achieved by cell population studies (histograms) using microspectrofluorimetry on single living cells. The results show a similar metabolic distribution pattern between dibenzo(c,h)acridine and benzo(a)pyrene, whereas important differences appear between 6-aminochrysene and dibenzo(c,h)acridine, respectively amine aromatic and N-heterocyclic aromatic compounds. No differences were observed in the metabolism of benzo(a)
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Silva, Daiana K. Frade, Sâmia S. Duarte, Thaís M. H. Lisboa, et al. "Antitumor Effect of a Novel Spiro-Acridine Compound is Associated with Up-Regulation of Th1-Type Responses and Antiangiogenic Action." Molecules 25, no. 1 (2019): 29. http://dx.doi.org/10.3390/molecules25010029.

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Tumor cells have specific features, including angiogenesis induction, cell cycle dysregulation, and immune destruction evasion. By inducing a T helper type 2 (Th2) immune response, tumor cells may favor immune tolerance within the tumor, which allows progression of cancer growth. Drugs with potential antitumor activity are the spiro-acridines, which is a promising new class of acridine compounds. Herein, the novel spiro-acridine (E)-5′-oxo-1′-((3,4,5-trimethoxybenzylidene)amino)-1′,5′-dihydro-10H-spiro[acridine-9,2′-pyrrole]-4′-carbonitrile (AMTAC-17) was synthesized and tested for antitumor e
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Dissertations / Theses on the topic "Acridine Compounds"

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OCAMPO, IVETTE Z. "Comparação e validação de técnicas clássicas e modificadas para estudos de potencial genotóxico de peptídeos utilizados na produção de radiofármacos." reponame:Repositório Institucional do IPEN, 2016. http://repositorio.ipen.br:8080/xmlui/handle/123456789/26378.

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Submitted by Claudinei Pracidelli (cpracide@ipen.br) on 2016-06-22T12:24:34Z No. of bitstreams: 0<br>Made available in DSpace on 2016-06-22T12:24:34Z (GMT). No. of bitstreams: 0<br>Dissertação (Mestrado em Tecnologia Nuclear)<br>IPEN/D<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP
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Barros, Francisco Washington AraÃjo. "Estudo do potencial anticÃncer de novos derivados acridÃnicos sintÃticos em modelos experimentais in vitro." Universidade Federal do CearÃ, 2010. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=4750.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>Acridinas sÃo molÃculas policÃclicas aromÃticas planares que possuem a capacidade de intercalar no DNA nuclear. Muitos dos seus representantes apresentam propriedades antibacterianas, antiparasitÃrias e antitumorais. O presente estudo avaliou o potencial citotÃxico de 22 novos compostos acridÃnicos em linhagens de cÃlulas tumorais humanas. Dentre esses, quatro compostos [5-(acridin-9-il-metileno)-3-(4-metil-benzil)-tiazolidina-2,4-diona, AC4; 5-(acridin-9-il-metileno)
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Tatibouët, Arnaud. "Synthèse et étude de bases de Troger comme sondes de chiralité de l'ADN." Université Joseph Fourier (Grenoble), 1996. http://www.theses.fr/1996GRE10245.

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Dans un programme de recherche de nouveaux heterocycles intercalants de l'adn, nous avons observe une totale regioselectivite de substitution electrophile en position 4 de la 3-aminoacridine. Ce resultat a ete utilise pour la synthese de bases de troger derivees d'aminoacridine. Les acridines etant connues pour leur affinite pour l'adn, les bases de troger correspondantes pourraient egalement interagir avec l'adn et grace a leur chiralite, leurs enantiomeres pourraient presenter differents modes d'association avec la macromolecule. Un enantiomere de la molecule pourrait alors reconnaitre speci
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Machado, Rafael Carvalhaes. "Síntese, caracterização e avaliações biológicas de 4-piridinil, 7-cloro-4-quinolinil e 9-acridinil, semicarbazidas e tiossemicarbazidas." Universidade Federal de Juiz de Fora, 2016. https://repositorio.ufjf.br/jspui/handle/ufjf/1143.

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Submitted by Renata Lopes (renatasil82@gmail.com) on 2016-04-12T18:36:46Z No. of bitstreams: 1 rafaelcarvalhaesmachado.pdf: 15330554 bytes, checksum: b28797a7ed7a97cc333b801efe362c9b (MD5)<br>Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2016-04-24T03:30:09Z (GMT) No. of bitstreams: 1 rafaelcarvalhaesmachado.pdf: 15330554 bytes, checksum: b28797a7ed7a97cc333b801efe362c9b (MD5)<br>Made available in DSpace on 2016-04-24T03:30:09Z (GMT). No. of bitstreams: 1 rafaelcarvalhaesmachado.pdf: 15330554 bytes, checksum: b28797a7ed7a97cc333b801efe362c9b (MD5)
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Demonchaux, Patrice. "Recherche d'agents radioprotecteurs : synthèse et mécanisme d'action de composés de type intercalant-aminothiol." Grenoble 1, 1988. http://www.theses.fr/1988GRE10016.

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Les intercalants utilises sont des amino-9 chloro-6 methoxy-2 acridines des amino-4 chloro-7 quinoleines et des amino-4 chloro-7 methyl-1 quinoleiniums sur lesquels ont ete introduites des chaines analogues a celles de la cysteamine et du wr 2727; etude de l'affinite de ces composes avec l'adn
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Fixler, Noémie. "Recherche de nouveaux agents anticancéreux dérivés d'acridine et de benzo(b)(1,7)phénanthroline : synthèse et étude de réactivité." Université Joseph Fourier (Grenoble), 1994. http://www.theses.fr/1994GRE10091.

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Recherchant de nouveaux anticancereux reagissant sur l'adn, nous avons synthetise differents derives de la 3-aminoacridine, de la proflavine, de la 10-hydroxy-benzo(b)(1,7)phenanthroline, et de la 6,9-dichloro-2-methoxyacridine. A une partie intercalante, nous avons ainsi associe une fonction alkylante dans le but d'augmenter l'activite biologique. Certains des nouveaux composes prepares sont des precurseurs potentiels de quinone-methides ou quinone-imine-methides, connus dans la litterature pour etre tres reactives. La reactivite des derives de type alcool benzylique, les plus interessants au
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Guillier, Fabrice. "Synthèse de produits naturels par association des réactions de métallation et de couplage. Accès à des alcaloïdes marins de type pyridoacridinique." Rouen, 1996. http://www.theses.fr/1996ROUES075.

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Ce travail décrit la préparation de structures de type pyridoacridone par fonctionnalisation de benzo[c][2,7]naphthyridines disubstituées en 4 et 5. Ces composés tétracycliques forment les structures de base pour un grand nombre d'alcaloïdes marins. La méthodologie employée pour la préparation de ces molécules repose sur l'utilisation des réactions de métallation et de couplage biarylique. Un nombre important de systèmes tricycliques de type benzo[c][2,7]naphthyridinique disubstitués en 4 et 5 sont synthétisés en une ou deux étapes à partir de pyridines trisubstituées. Au cours de ce travail,
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Hunter, Douglas Ralph. "Sorption of acridine to unbonded silica and the influence of pH and counterion concentration." 1989. http://etd.library.arizona.edu/etd/GetFileServlet?file=file:///data1/pdf/etd/azu_e9791_1989_365_sip1_w.pdf&type=application/pdf.

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江子昂. "Synthesis and Characterization of Novel Polycyclic Aza-Aromatic Compounds and Acridine Derivatives." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/23dypd.

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Book chapters on the topic "Acridine Compounds"

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Henry, David W. "Acridine Antimalarials." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186596.ch19.

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Tilak, B. D., and N. R. Ayyangar. "Acridine Dyes." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186596.ch9.

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Saxton, J. E. "The Acridine Alkaloids." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186596.ch5.

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Raulins, N. R. "Acridines." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186596.ch2.

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Nicholson, B. H. "Acridines and Enzymes." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186596.ch16.

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Mccapra, Frank. "Chemiluminescent Reactions of Acridines." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186596.ch10.

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Robinson, D. A. "Benzacridines and Condensed Acridines." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186596.ch8.

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Acheson, R. M. "The Infrared Spectra of Acridines." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186596.ch12.

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Bolton, R. G. "The Mass Spectra of Acridines." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186596.ch14.

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Dean, A. C. R. "The Antibacterial Action of Acridines." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186596.ch17.

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