Relevant bibliographies by topics / Acridine Derivatives

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Academic literature on the topic 'Acridine Derivatives'

Author: Grafiati
Published: 4 June 2021
Last updated: 26 July 2025

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Journal articles on the topic "Acridine Derivatives"

1

Galenko, Ekaterina E., Mikhail S. Novikov, Alexander S. Bunev, and Alexander F. Khlebnikov. "Acridine–Isoxazole and Acridine–Azirine Hybrids: Synthesis, Photochemical Transformations in the UV/Visible Radiation Boundary Region, and Anticancer Activity." Molecules 29, no. 7 (2024): 1538. http://dx.doi.org/10.3390/molecules29071538.

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Easy-to-handle N-hydroxyacridinecarbimidoyl chloride hydrochlorides were synthesized as convenient nitrile oxide precursors in the preparation of 3-(acridin-9/2-yl)isoxazole derivatives via 1,3-dipolar cycloaddition with terminal alkynes, 1,1-dichloroethene, and acrylonitrile. Azirines with an acridin-9/2-yl substituent attached directly or via the 1,2,3-triazole linker to the azirine C2 were also synthesized. The three-membered rings of the acridine–azirine hybrids were found to be resistant to irradiation in the UV/visible boundary region, despite their long-wave absorption at 320–420 nm, in
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Khunnawutmanotham, Nisachon, Watthanachai Jumpathong, Chatchakorn Eurtivong, Nitirat Chimnoi, and Supanna Techasakul. "Synthesis, cytotoxicity evaluation, and molecular modeling studies of 2,N10-substituted acridones as DNA-intercalating agents." Journal of Chemical Research 44, no. 7-8 (2020): 410–25. http://dx.doi.org/10.1177/1747519820902674.

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Acridine-based compounds possess anticancer activities by intercalating to DNA. Although they have chemotherapeutic potential, acridine-based compounds are not used to treat cancer. In this study, 2, N10-acridone derivatives are designed and synthesized based on acridone, a ketone derivative of acridine. Herein, acridone is functionalized with alkyl side chains containing terminal nitrogen-based moieties at the N10-position and substituted at the C2-position. The products are evaluated for in vitro cytotoxicity against four cancer cell lines: Molt-3, HepG2, A549, and HuCCA-1. The derivative be
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Varakumar, Potlapati, Kalirajan Rajagopal, Baliwada Aparna, et al. "Acridine as an Anti-Tumour Agent: A Critical Review." Molecules 28, no. 1 (2022): 193. http://dx.doi.org/10.3390/molecules28010193.

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This review summarized the current breakthroughs in the chemistry of acridines as anti-cancer agents, including new structural and biologically active acridine attributes. Acridine derivatives are a class of compounds that are being extensively researched as potential anti-cancer drugs. Acridines are well-known for their high cytotoxic activity; however, their clinical application is restricted or even excluded as a result of side effects. The photocytotoxicity of propyl acridine acts against leukaemia cell lines, with C1748 being a promising anti-tumour drug against UDP-UGT’s. CK0403 is repor
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Othman, Salem, and Maria Kozurkova. "Sulfur Containing Acridine Derivatives in Preclinical Studies with Cancer Cell Lines." Current Medicinal Chemistry 25, no. 17 (2018): 1968–75. http://dx.doi.org/10.2174/0929867324666170414165019.

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Background: The possible use of acridines as anticancer agents was first considered in the 1920´s. Since then, a large number of acridine drugs have been tested as antitumour agents, including compounds containing sulphur on the acridine chromophore. In this review, we will discuss recent studies which have investigated the anticancer activity of this class of acridine derivatives. Methods: We present the results both of our own decade-long research and also of existing research literature into the anticancer activity of acridine derivatives containing sulphur. The evidence of specific tumor-c
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Gabriel, Iwona. "‘Acridines’ as New Horizons in Antifungal Treatment." Molecules 25, no. 7 (2020): 1480. http://dx.doi.org/10.3390/molecules25071480.

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Frequent fungal infections in immunocompromised patients and mortality due to invasive mycosis are important clinical problems. Opportunistic pathogenic Candida species remain one of the leading causes of systemic mycosis worldwide. The repertoire of antifungal chemotherapeutic agents is very limited. Although new antifungal drugs such as lanosterol 14α-demethylase and β-glucan synthase inhibitors have been introduced into clinical practice, the development of multidrug resistance has become increasingly significant. The urgency to expand the range of therapeutic options for the treatment of f
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Magesh M and Gandhimathi R. "An overview of pharmacological activities of acridine derivatives." International Journal of Research in Pharmaceutical Sciences 11, no. 4 (2020): 6922–31. http://dx.doi.org/10.26452/ijrps.v11i4.3683.

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The derivatives of acridine can be served as a lead molecule of an antibacterial, anti-viral antiprotozoal, anti-viral, antitubercular, anti-fungal, anti-malarial and anti-cancer agents. Even though the usage of acridine becomes limited due to its side effects, so many potent and safe compounds can be derived through molecular modification in the acridine ring. Since the resistance of pathogens and tumour cells has become more common nowadays, it necessitates the search of new drug candidates. Since the treatment and management of Alzheimer's disease is such a complicated and proper drug regim
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SANTANU, BHATTACHARYA, and THOMAS MINI. "DNA Binding Properties of Some Cationic Acridine Derivatives." Journal of Indian Chemical Society Vol. 75, Oct-Dec 1998 (1998): 716–24. https://doi.org/10.5281/zenodo.5917140.

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Department of Organic Chemistry, Indian Institute of Science, Bangalore-560 012<strong> </strong> <em>Manuscript received 17 August 1998</em> Four cationic acridine derivatives have been synthesized. The positively charged amine residue in one of these is connected directly on to the acridine nucleus and in three other acridines, the amines are connected via a 9-CH<sub>2</sub> unit to acridine. We have investigated the binding of these acridines with mammalian DNA by absorption titration, UV- and induced-CD spectroscopy and competitive ethidium bromide displacement fluorescence assay. The effe
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Galy, Jean-Pierre, Sandrine Morel, Gérard Boyer, and José Elguero. "Tetracyclic derivatives of acridine. Heterofused acridines." Journal of Heterocyclic Chemistry 33, no. 6 (1996): 1551–60. http://dx.doi.org/10.1002/jhet.5570330601.

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Rádl, Stanislav. "Preparation of 1-Hydroxyxanthen-9(9H)-ones and 1-Hydroxyacridin-9(10H)-ones via Corresponding 3,4-Dihydro-1,9(2H)-diones." Collection of Czechoslovak Chemical Communications 60, no. 12 (1995): 2127–36. http://dx.doi.org/10.1135/cccc19952127.

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Target 10-cyclopropyl-7-fluoro-1-hydroxy-6-(4-methyl-1-piperazinyl)acridin-9(10H)-one (IVc) and 7-fluoro-1-hydroxy-6-(4-methyl-1-piperazinyl)-9H-xanthen-9-one (IVd) were obtained from corresponding difluoro derivatives IVa and IVb, respectively. These intermediates were synthesized via respective 3,4-dihydro-1,9(2H)-diones Va and Vb. Acridine derivative (10-cyclopropyl-6,7-difluoro-3,4-dihydro-1H-acridine-1,9(2H,10H)-dione, Va) was synthesized from 1-cyclopropyl-6,7-difluoroisatoic anhydride (XI) and xanthene derivative (6,7-difluoro-3,4-dihydro-1H-xanthen-1,9(2H)-dione, Vb) from cyclohexenone
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Krochtová, Kristína, Annamária Halečková, Ladislav Janovec, Michaela Blizniaková, Katarína Kušnírová, and Mária Kožurková. "Novel 3,9-Disubstituted Acridines with Strong Inhibition Activity against Topoisomerase I: Synthesis, Biological Evaluation and Molecular Docking Study." Molecules 28, no. 3 (2023): 1308. http://dx.doi.org/10.3390/molecules28031308.

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A series of novel 3,9-disubstituted acridines were synthesized and their biological potential was investigated. The synthetic plan consists of eight reaction steps, which produce the final products, derivatives 17a–17j, in a moderate yield. The principles of cheminformatics and computational chemistry were applied in order to study the relationship between the physicochemical properties of the 3,9-disubstituted acridines and their biological activity at a cellular and molecular level. The selected 3,9-disubstituted acridine derivatives were studied in the presence of DNA using spectroscopic (U
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Dissertations / Theses on the topic "Acridine Derivatives"

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Hagan, Damien James. "The synthesis of novel anti-cancer acridine derivatives." Thesis, University of Nottingham, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284428.

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Modi, Chetna. "Structure selective DNA recognition by a novel class of polycyclic acridine derivatives." Thesis, University of Nottingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395583.

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Leontiou, Chrysoula. "Mechanisms of drug resistance to acridine derivatives mediated by human DNA topoisomerase IIβ." Thesis, University of Newcastle Upon Tyne, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273685.

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Hussein, Belal Hussein Mohamed. "Cyclic and linear photoionizations of acridine derivatives and xanthone investigated by nanosecond laser flash photolysis." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=984723420.

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Rocha, Eleusa Maria Ferreira. "Mecanismo molecular envolvido na resistência aos derivados de acridina e ao antimicótico tioconazol em Aspergillus nidulans." Universidade de São Paulo, 2002. http://www.teses.usp.br/teses/disponiveis/17/17135/tde-06032003-092850/.

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A humanidade tem aumentado drasticamente o uso de antibióticos, antifúngicos, inseticidas, herbicidas e agentes quimioterápicos para tratar infecções, câncer e obter ganho econômico com a produção agrícola e industrial. O repetido uso destas substâncias leva freqüentemente à sua ineficiência devido à seleção de organismos resistentes ou tolerantes, com graves conseqüências econômicas e sociais. Os mecanismos envolvidos no processo de resistência à antifúngicos são pouco conhecidos. A compreensão destes mecanismos auxiliará no desenvolvimento de estratégias para a identificação de isolados clí
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Komati, Rajesh. "Cu (II) Catalyzed Gateways In The Synthesis of Acridine Derivatives and Their Biological Evaluation as Anti-Cancer Drugs." ScholarWorks@UNO, 2014. http://scholarworks.uno.edu/td/1818.

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Telomeres are nucleoprotein complexes found at the ends of linear eukaryotic chromosomes. Telomeres consist of a short sequence of repetitive double stranded DNA, TTAGGG repeats in humans (and all mammals), and a complex of 6 proteins, termed the shelterin complex. The length of the telomeres varies greatly between species, from approximately 300 base pairs in yeast to many 10-15 kilo bases in humans, because of the end replication problem this length get shorten with each cell division and ultimately leads to cell death. However the immortal eukaryotic cells and some transformed human cells o
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Tatibouët, Arnaud. "Synthèse et étude de bases de Troger comme sondes de chiralité de l'ADN." Université Joseph Fourier (Grenoble), 1996. http://www.theses.fr/1996GRE10245.

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Dans un programme de recherche de nouveaux heterocycles intercalants de l'adn, nous avons observe une totale regioselectivite de substitution electrophile en position 4 de la 3-aminoacridine. Ce resultat a ete utilise pour la synthese de bases de troger derivees d'aminoacridine. Les acridines etant connues pour leur affinite pour l'adn, les bases de troger correspondantes pourraient egalement interagir avec l'adn et grace a leur chiralite, leurs enantiomeres pourraient presenter differents modes d'association avec la macromolecule. Un enantiomere de la molecule pourrait alors reconnaitre speci
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Ndlebe, Thabisile S. "Oxidative Damage in DNA: an Exploration of Various DNA Structures." Diss., Available online, Georgia Institute of Technology, 2006, 2006. http://etd.gatech.edu/theses/available/etd-05112006-154326/.

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Thesis (Ph. D.)--Chemistry and Biochemistry, Georgia Institute of Technology, 2007.<br>Donald F. Doyle, Committee Member ; Bridgette Anne Barry, Committee Member ; Dr. Gary B. Schuster, Committee Chair ; Nicholas V. Hud, Committee Member ; Roger M. Wartell, Committee Member.
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Jourdan, Muriel. "Les lésions abasiques de l'ADN : étude par RMN et interaction avec des drogues." Université Joseph Fourier (Grenoble ; 1971-2015), 1998. http://www.theses.fr/1998GRE10255.

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Notre travail s'inscrit dans le cadre de l'etude par resonance magnetique nucleaire (rmn) d'une des lesions majeures de l'adn : le site abasique. Celui-ci resulte de la perte d'une base nucleique conduisant a la formation du 2-desoxyribose ou de sa forme oxyde, la 2-desoxyribonolactone. La 2-desoxyribonolactone fait l'objet de nombreux travaux mais reste une lesion mal connue, tant d'un point de vue chimique, biologique que structural. Nous avons determine par rmn et modelisation moleculaire, la premiere structure d'un oligonucleotide contenant cette lesion. Par comparaison avec la structure d
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Fixler, Noémie. "Recherche de nouveaux agents anticancéreux dérivés d'acridine et de benzo(b)(1,7)phénanthroline : synthèse et étude de réactivité." Université Joseph Fourier (Grenoble), 1994. http://www.theses.fr/1994GRE10091.

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Recherchant de nouveaux anticancereux reagissant sur l'adn, nous avons synthetise differents derives de la 3-aminoacridine, de la proflavine, de la 10-hydroxy-benzo(b)(1,7)phenanthroline, et de la 6,9-dichloro-2-methoxyacridine. A une partie intercalante, nous avons ainsi associe une fonction alkylante dans le but d'augmenter l'activite biologique. Certains des nouveaux composes prepares sont des precurseurs potentiels de quinone-methides ou quinone-imine-methides, connus dans la litterature pour etre tres reactives. La reactivite des derives de type alcool benzylique, les plus interessants au
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Books on the topic "Acridine Derivatives"

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Ježek, Jan, Jan Hlaváček, and Jaroslav Šebestík. Biomedical Applications of Acridines: Derivatives, Syntheses, Properties and Biological Activities with a Focus on Neurodegenerative Diseases. Springer, 2017.

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Ježek, Jan, Jan Hlaváček, and Jaroslav Šebestík. Biomedical Applications of Acridines: Derivatives, Syntheses, Properties and Biological Activities with a Focus on Neurodegenerative Diseases. Springer, 2018.

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Book chapters on the topic "Acridine Derivatives"

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Gundermann, Karl-Dietrich, and Frank McCapra. "Acridine Derivatives." In Reactivity and Structure: Concepts in Organic Chemistry. Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-71645-4_8.

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Missailidis, S., E. Giménez-Arnau, D. J. Hagan, A. F. Drake, and M. F. G. Stevens. "Spectroscopic Studies of the Interactions Between DNA and Novel Polycyclic Acridine Derivatives." In Spectroscopy of Biological Molecules: Modern Trends. Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-011-5622-6_175.

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Simoes, H. Agudo, C. B. C. Silva, and R. M. Chaloub. "Effects of Acridine Derivatives on Energy Transduction in Thylakoid Membranes of Anabaena sp." In Current Research in Photosynthesis. Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-009-0511-5_414.

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Gooch, Jan W. "Acridine Derivative." In Encyclopedic Dictionary of Polymers. Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_13044.

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Dzierzbicka, Krystyna, Aleksander M. Kolodziejczyk, Danuta Sosnowska, and Andrzej Mysliwski. "Anti-HIV and anticancer activity of MDP and acridine derivative conjugates." In Peptides 1992. Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1470-7_408.

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Wang, L., and M. Liu. "15.9.5 Acridines (Update 2024)." In Knowledge Updates 2024/1. Georg Thieme Verlag KG, 2023. http://dx.doi.org/10.1055/sos-sd-115-01517.

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Abstract Acridine derivatives form a class of nitrogen-containing compounds with a broad spectrum of biological activity, including against cancer, bacteria, parasites, HIV, fungi, and Alzheimer’s disease. This is an update to the previous Science of Synthesis contribution covering methods for the preparation of acridines, focusing on advances reported between 2005 and 2022.
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Conference papers on the topic "Acridine Derivatives"

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Géci, Imrich, Vyacheslav V. Filichev, and Erik B. Pedersen. "Synthesis of twisted intercalating nucleic acids (TINA) possesing acridine derivatives." In XIIIth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2005. http://dx.doi.org/10.1135/css200507401.

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Pereira, Ana Ligia da, Ricardo Moura, Francisco Mendonça Júnior, Luciana Scotti, and Marcus Scotti. "Antimalarial acridine N-acylidrazonic derivatives: ADME in silico studies and molecular." In MOL2NET 2018, International Conference on Multidisciplinary Sciences, 4th edition. MDPI, 2018. http://dx.doi.org/10.3390/mol2net-04-05524.

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Teletina, Karmelina, Nikola Fišić, Maja Ranković, Jelena Rupar, Maja Milojević-Rakić, and Anka Jevremović. "INVESTIGATION OF THE RELEASE OF NOVEL ACRIDINE DERIVATIVE SUPPORTED ONTO Y ZEOLITE." In 17th International Conference on Fundamental and Applied Aspects of Physical Chemistry. Society of Physical Chemists of Serbia, 2024. https://doi.org/10.46793/phys.chem24i.321t.

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This study investigated 2-(acridin-9-ylamino)-3-(1H-indol-3-yl)propanoic acid, acridine derivative as a potential anticancer drug supported on FAU type zeolite Y. Y zeolite before and after the drug impregnation was characterized with the scanning electron microscopy and thermogravimetry, while HPLC/FL and spectrofluorimetry were employed for drug quantification. The morphology of the zeolite did not change during the drug impregnation process, and the resulting drug loading was 17.9 mg/g. The release of 1.2 µM acridine derivative concentration necessary for targeted cancer cytotoxicity and fa
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