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Dissertations / Theses on the topic 'Acridine Derivatives'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Hagan, Damien James. "The synthesis of novel anti-cancer acridine derivatives." Thesis, University of Nottingham, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284428.

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2

Modi, Chetna. "Structure selective DNA recognition by a novel class of polycyclic acridine derivatives." Thesis, University of Nottingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395583.

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3

Leontiou, Chrysoula. "Mechanisms of drug resistance to acridine derivatives mediated by human DNA topoisomerase IIÎ²." Thesis, University of Newcastle Upon Tyne, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273685.

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4

Hussein, Belal Hussein Mohamed. "Cyclic and linear photoionizations of acridine derivatives and xanthone investigated by nanosecond laser flash photolysis." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=984723420.

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5

Rocha, Eleusa Maria Ferreira. "Mecanismo molecular envolvido na resistência aos derivados de acridina e ao antimicótico tioconazol em Aspergillus nidulans." Universidade de São Paulo, 2002. http://www.teses.usp.br/teses/disponiveis/17/17135/tde-06032003-092850/.

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A humanidade tem aumentado drasticamente o uso de antibióticos, antifúngicos, inseticidas, herbicidas e agentes quimioterápicos para tratar infecções, câncer e obter ganho econômico com a produção agrícola e industrial. O repetido uso destas substâncias leva freqüentemente à sua ineficiência devido à seleção de organismos resistentes ou tolerantes, com graves conseqüências econômicas e sociais. Os mecanismos envolvidos no processo de resistência à antifúngicos são pouco conhecidos. A compreensão destes mecanismos auxiliará no desenvolvimento de estratégias para a identificação de isolados clí

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6

Komati, Rajesh. "Cu (II) Catalyzed Gateways In The Synthesis of Acridine Derivatives and Their Biological Evaluation as Anti-Cancer Drugs." ScholarWorks@UNO, 2014. http://scholarworks.uno.edu/td/1818.

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Telomeres are nucleoprotein complexes found at the ends of linear eukaryotic chromosomes. Telomeres consist of a short sequence of repetitive double stranded DNA, TTAGGG repeats in humans (and all mammals), and a complex of 6 proteins, termed the shelterin complex. The length of the telomeres varies greatly between species, from approximately 300 base pairs in yeast to many 10-15 kilo bases in humans, because of the end replication problem this length get shorten with each cell division and ultimately leads to cell death. However the immortal eukaryotic cells and some transformed human cells o

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7

Tatibouët, Arnaud. "Synthèse et étude de bases de Troger comme sondes de chiralité de l'ADN." Université Joseph Fourier (Grenoble), 1996. http://www.theses.fr/1996GRE10245.

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Dans un programme de recherche de nouveaux heterocycles intercalants de l'adn, nous avons observe une totale regioselectivite de substitution electrophile en position 4 de la 3-aminoacridine. Ce resultat a ete utilise pour la synthese de bases de troger derivees d'aminoacridine. Les acridines etant connues pour leur affinite pour l'adn, les bases de troger correspondantes pourraient egalement interagir avec l'adn et grace a leur chiralite, leurs enantiomeres pourraient presenter differents modes d'association avec la macromolecule. Un enantiomere de la molecule pourrait alors reconnaitre speci

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8

Ndlebe, Thabisile S. "Oxidative Damage in DNA: an Exploration of Various DNA Structures." Diss., Available online, Georgia Institute of Technology, 2006, 2006. http://etd.gatech.edu/theses/available/etd-05112006-154326/.

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Thesis (Ph. D.)--Chemistry and Biochemistry, Georgia Institute of Technology, 2007.<br>Donald F. Doyle, Committee Member ; Bridgette Anne Barry, Committee Member ; Dr. Gary B. Schuster, Committee Chair ; Nicholas V. Hud, Committee Member ; Roger M. Wartell, Committee Member.

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9

Jourdan, Muriel. "Les lésions abasiques de l'ADN : étude par RMN et interaction avec des drogues." Université Joseph Fourier (Grenoble ; 1971-2015), 1998. http://www.theses.fr/1998GRE10255.

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Notre travail s'inscrit dans le cadre de l'etude par resonance magnetique nucleaire (rmn) d'une des lesions majeures de l'adn : le site abasique. Celui-ci resulte de la perte d'une base nucleique conduisant a la formation du 2-desoxyribose ou de sa forme oxyde, la 2-desoxyribonolactone. La 2-desoxyribonolactone fait l'objet de nombreux travaux mais reste une lesion mal connue, tant d'un point de vue chimique, biologique que structural. Nous avons determine par rmn et modelisation moleculaire, la premiere structure d'un oligonucleotide contenant cette lesion. Par comparaison avec la structure d

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10

Fixler, Noémie. "Recherche de nouveaux agents anticancéreux dérivés d'acridine et de benzo(b)(1,7)phénanthroline : synthèse et étude de réactivité." Université Joseph Fourier (Grenoble), 1994. http://www.theses.fr/1994GRE10091.

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Recherchant de nouveaux anticancereux reagissant sur l'adn, nous avons synthetise differents derives de la 3-aminoacridine, de la proflavine, de la 10-hydroxy-benzo(b)(1,7)phenanthroline, et de la 6,9-dichloro-2-methoxyacridine. A une partie intercalante, nous avons ainsi associe une fonction alkylante dans le but d'augmenter l'activite biologique. Certains des nouveaux composes prepares sont des precurseurs potentiels de quinone-methides ou quinone-imine-methides, connus dans la litterature pour etre tres reactives. La reactivite des derives de type alcool benzylique, les plus interessants au

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11

Hevér, Aniko. "Inhibition of P-glycoprotein mediated efflux and modulation of MDR-1 gene expression in tumor cells by newly synthesised azaheteroyclic derivatives." Aix-Marseille 2, 1998. http://theses.univ-amu.fr.lama.univ-amu.fr/PHA_1998_1512.pdf.

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12

Pedro, Maria Beatriz Pinto Lopes. "Computational Study of the interaction of acridine derivatives with DNA." Master's thesis, 2020. http://hdl.handle.net/10773/29324.

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DNA is a significant target for the treatment of many diseases, including cancer. DNA intercalation is the process by which small molecules containing planar aromatic or heteroaromatic systems, are inserted between the adjacent DNA base pairs. Intercalation leads to many conformational changes in DNA with concomitant interference with its biological functions. Experimental procedures to evaluate the binding mode between drug candidates and DNA involve risks and are time and money consuming. These drawbacks can be avoided with the use of computer-aided techniques. Acridines and its derivatives

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13

江子昂. "Synthesis and Characterization of Novel Polycyclic Aza-Aromatic Compounds and Acridine Derivatives." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/23dypd.

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14

Hussein, Belal Hussein Mohamed [Verfasser]. "Cyclic and linear photoionizations of acridine derivatives and xanthone investigated by nanosecond laser flash photolysis / von Belal Hussein Mohamed Hussein." 2005. http://d-nb.info/984723420/34.

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15

Chih-BoKao and 高至柏. "Synthesis of Benzo[b]acridines Derivatives from2-Amino-1,4-naphthoquinones via MetallicOxidation Reaction." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/25408958886311084812.

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碩士<br>國立成功大學<br>化學系碩博士班<br>101<br>Metallic oxidatioin reaction is an important method in organic synthesis. In the past decades, it has been widely used for synthesis of various organic compounds. This thesis will be developed in different metallic oxidation reaction to synthesize benzo[b]acridine derivatives. This thesis is divided into four parts, the first three parts is using different metallic oxidation reaction to synthesize benzo[b]acridine compounds, the fourth part is synthesis of benzo[b]naphtho[2,3-f]azepine via iodine promoted cyclization.

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16

Chang-YouSie and 謝昌佑. "Synthesis of Acridines and Azepines from 1,4- Quinone Derivatives via Free Radical Reaction and Electrophilic Reaction." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/4xv5z6.

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碩士<br>國立成功大學<br>化學系<br>105<br>SUMMARY The methods which use free radicals for cyclization reaction can be found in many literatures. Herein we used sulfonyl radical with the compounds that contain triple bond in the presence of silver(I) nitrate and potassium persulfate via the oxidative free radical cyclization reaction to synthesis benzo[b]acridine derivatives. Surprisingly, we found that azepine derivatives were produced as the by-products under certain conditions. So we divided the reaction into two steps to synthesis benzo[b]naphtho[2,3-f]azepine derivatives alone. Keywords: silver(I) nit

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17

JHANG, JIA-WEI, and 張家瑋. "Part 1: Design and Attempted Synthesis of Acridone Derivatives as Potential ABC Transporters Inhibitors,Part 2: Design and Synthesis of Pyrazole Derivatives as System xc- Inhibitors." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/qg9258.

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碩士<br>東海大學<br>化學系<br>105<br>Part 1: ABC(ATP-binding cassette) transporter proteins are responsible for the cellular efflux of metabolites or toxic substances to protect cells. Overexpression of ABC transporter protein occur when tumor cells are stimulated continuously by chemotherapeutic drugs,that to causing lack of drug accumulation drugs which lead to development of multidrug resistance (MDR). The development of MDR is a major obstacle to successful chemotherapeutic treatment of cancer patients. Acridones are naturally occurring alkaloids and one of its derivatives, Elacridar was shown to

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