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Journal articles on the topic 'Act on the Safety of Regenerative Medicine'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Tobita, Morikuni, Kenji Konomi, Yasuhiro Torashima, Kenichi Kimura, Masaomi Taoka, and Masahiro Kaminota. "Japan's challenges of translational regenerative medicine: Act on the safety of regenerative medicine." Regenerative Therapy 4 (June 2016): 78–81. http://dx.doi.org/10.1016/j.reth.2016.04.001.

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Hosoya, Satoshi, Sena Awano-Kim, Ryo Yokomizo, et al. "Regenerative medicine in Obstetrics & Gynecology: Current status under the Act on the Safety of Regenerative Medicine in Japan." Regenerative Therapy 26 (June 2024): 564–70. http://dx.doi.org/10.1016/j.reth.2024.08.003.

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3

Raut, Sayali, Anuja Ikhar, and Jay Bhopatkar. "Glass that Heals: Exploring the Wonders of Bioactive Glass." Journal of Datta Meghe Institute of Medical Sciences University 18, no. 4 (2023): 860–63. http://dx.doi.org/10.4103/jdmimsu.jdmimsu_189_23.

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Abstract In today’s world, dental and bone defect incidences have become very common, and regenerative treatment has shown very effective results. As such, it might affect the whole quality of life of an individual. Moreover, the present studies show that now, it is possible to heal or treat certain dental diseases by use of some regenerative material and bioactive glass (BAG) is one of them and also is proved to be helpful in various dermatological conditions. Its safety and effectiveness are more as compared to other biomaterials. This review focuses on one of the versatile materials which a

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4

Lebiedzińska, Julia. "Polydeoxyribonucleotides – the future of regenerative medicine." Aesthetic Cosmetology and Medicine 14, no. 3 (2025): 115–20. https://doi.org/10.52336/acm.2025.017.

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Polydeoxyribonucleotides (PDRN) are fragments of deoxyribonucleic acid (DNA) obtained from fish sperm. They have the ability to stimulate angiogenesis, i.e., the formation of new blood vessels. The article aimed to present the current state of knowledge of the potential use of PDRN in regenerative and aesthetic medicine. Their mechanisms of action were discussed, including their ability to stimulate angiogenesis, collagen synthesis, and anti-inflammatory effects. The results of the latest scientific research indicate the effectiveness of PDRN in anti-aging treatments, scars, stretch marks, and

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5

Khushi, Patel* Hitesh Raval. "An Overview on Japan's Regenerative Medicine Policies: Cellular and Tissue-Based Products Examined." International Journal of Pharmaceutical Sciences 3, no. 2 (2025): 1290–311. https://doi.org/10.5281/zenodo.14878652.

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Human cells and tissue products belong to a relatively new class of medical products. The products were classified as human cells, tissue, and cellular and tissue-based products (HCT/Ps) in the US, advanced therapy medicinal products (ATMPs) in the EU, and cell/tissue-engineered products in Japan. The Ministry of Health, Labour and Welfare (MHLW) and the Pharmaceuticals and Medical Devices Agency (PMDA) are the key regulatory authorities overseeing these products. The Pharmaceutical and Medical Device Act, Japan 2013 Chapter 9: Section 6 Handling of Cellular and Tissue-based Products (Articles

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Sameshima, Tadashi. "The Change of Research and Development Environment by Act on the Safety of Regenerative Medicine and Revised Pharmaceutical Affairs Act:." Iryo To Shakai 28, no. 1 (2018): 103–13. http://dx.doi.org/10.4091/iken.29.033.

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7

Thomas, Nebu George, Lekshmi M, Thomas George.V, and Kavya S. "Biological modifiers in bone graft for periodontal regeneration." IP International Journal of Periodontology and Implantology 8, no. 2 (2023): 86–93. http://dx.doi.org/10.18231/j.ijpi.2023.018.

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Periodontal diseases such as gingivitis and periodontitis leads to degradation of periodontal tissues, causing tooth movement, and eventually tooth loss. Regenerative periodontal therapies aim to promote the healing and regeneration of the damaged periodontal tissues. These therapies focus on restoring the lost periodontal structures, including the gum tissue, periodontal ligament, and bone, to a functional state. To promote periodontal regeneration and healing, the application of biologic modifiers such as growth factors has been investigated. Biologic modifiers-primarily growth factors are b

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8

Tobita, Morikuni. "Current state and issues related to cell therapy under the Act on the Safety of Regenerative Medicine." Personalized Medicine Universe 7 (July 2018): 37–38. http://dx.doi.org/10.1016/j.pmu.2018.04.003.

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9

Uno, Y., K. Nakamura, M. Tobita, et al. "Compilation and Issue of Basic Points to Consider for Cell Storage under the Act on the Safety of Regenerative Medicine by the Japanese Society for Regenerative Medicine." Cytotherapy 27, no. 5 (2025): S130—S131. https://doi.org/10.1016/j.jcyt.2025.03.257.

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10

Wang, Lei, Yefan Duan, Shujie Lu, and Jianfei Sun. "Magnetic Nanomaterials Mediate Electromagnetic Stimulations of Nerves for Applications in Stem Cell and Cancer Treatments." Journal of Functional Biomaterials 14, no. 2 (2023): 58. http://dx.doi.org/10.3390/jfb14020058.

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Although some progress has been made in the treatment of cancer, challenges remain. In recent years, advancements in nanotechnology and stem cell therapy have provided new approaches for use in regenerative medicine and cancer treatment. Among them, magnetic nanomaterials have attracted widespread attention in the field of regenerative medicine and cancer; this is because they have high levels of safety and low levels of invasibility, promote stem cell differentiation, and affect biological nerve signals. In contrast to pure magnetic stimulation, magnetic nanomaterials can act as amplifiers of

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11

Arita, Anna, and Morikuni Tobita. "Current status of platelet-rich plasma therapy under the act on the safety of regenerative medicine in Japan." Regenerative Therapy 23 (June 2023): 37–43. http://dx.doi.org/10.1016/j.reth.2023.03.001.

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12

Uno, Yuki, Kazuaki Nakamura, Morikuni Tobita, et al. "Basic Points to Consider for Cell Storage under the Act on the Safety of Regenerative Medicine in Japan." Regenerative Therapy 30 (December 2025): 252–58. https://doi.org/10.1016/j.reth.2025.06.011.

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13

Kawase, Tomoyuki, and Kazuhiro Okuda. "Comprehensive Quality Control of the Regenerative Therapy Using Platelet Concentrates: The Current Situation and Prospects in Japan." BioMed Research International 2018 (2018): 1–10. http://dx.doi.org/10.1155/2018/6389157.

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Platelet concentrates (PCs), represented by platelet-rich plasma (PRP), have been widely applied in the fields of regenerative and aesthetic therapies. PCs’ mechanisms of action, however, are too complicated, and it is not easy to present the whole picture; besides, clinical outcomes are hardly reproducible in many cases. Therefore, several medically advanced countries seemingly intend to regulate PC therapies weakly or strictly because of the increasing popularity. Japan established laws and regulations for PC therapy in the “Act on the Safety of Regenerative Medicine” along with the “Pharmac

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Bua, Gloria, Pasquale Marrazzo, Elisabetta Manaresi, et al. "Non-Permissive Parvovirus B19 Infection: A Reservoir and Questionable Safety Concern in Mesenchymal Stem Cells." International Journal of Molecular Sciences 24, no. 9 (2023): 8204. http://dx.doi.org/10.3390/ijms24098204.

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Mesenchymal stromal/stem cells (MSCs) are multipotent cells with differentiation, immunoregulatory and regenerative properties. Because of these features, they represent an attractive tool for regenerative medicine and cell-based therapy. However, MSCs may act as a reservoir of persistent viruses increasing the risk of failure of MSCs-based therapies and of viral transmission, especially in immunocompromised patients. Parvovirus B19V (B19V) is a common human pathogen that infects bone marrow erythroid progenitor cells, leading to transient or persistent anemia. Characteristics of B19V include

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15

Yokomizo, Ryo, Satoshi Hosoya, Akihiro Umezawa, and Aikou Okamoto. "Amendment of the Act on the Safety of Regenerative Medicine: A new voyage of regenerative medicine in Japan and the dawn of a new era for young investigators." Regenerative Therapy 29 (June 2025): 237–46. https://doi.org/10.1016/j.reth.2025.03.011.

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16

Kawamata, Shin. "FACILITY REQUIREMENTS FOR SPECIFIED CELL PROCESSING PRODUCT MANUFACTURING FACILITIES OPERATED UNDER THE ACT ON SECURING SAFETY OF REGENERATIVE MEDICINE." Japanese Journal of Transfusion and Cell Therapy 67, no. 6 (2021): 567–72. http://dx.doi.org/10.3925/jjtc.67.567.

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17

Ikka, Tsunakuni, Misao Fujita, Taichi Hatta, et al. "Difficulties in ensuring review quality performed by committees under the Act on the Safety of Regenerative Medicine in Japan." Stem Cell Reports 18, no. 5 (2023): 1247. http://dx.doi.org/10.1016/j.stemcr.2023.04.006.

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18

Zhao, Ashley G., Kiran Shah, Brett Cromer, and Huseyin Sumer. "Mesenchymal Stem Cell-Derived Extracellular Vesicles and Their Therapeutic Potential." Stem Cells International 2020 (August 24, 2020): 1–10. http://dx.doi.org/10.1155/2020/8825771.

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Extracellular vesicles (EVs) are cell-derived membrane-bound nanoparticles, which act as shuttles, delivering a range of biomolecules to diverse target cells. They play an important role in maintenance of biophysiological homeostasis and cellular, physiological, and pathological processes. EVs have significant diagnostic and therapeutic potentials and have been studied both in vitro and in vivo in many fields. Mesenchymal stem cells (MSCs) are multipotent cells with many therapeutic applications and have also gained much attention as prolific producers of EVs. MSC-derived EVs are being explore

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19

Hosoya, Satoshi, Yuichiro Ukon, Kazuki Morita, Eisuke Minegishi, Jun Sugihara, and Manabu Hasegawa. "Detailed revisions to the subordinate regulation following the amendment of the Act on the Safety of Regenerative Medicine in Japan." Regenerative Therapy 30 (December 2025): 217–23. https://doi.org/10.1016/j.reth.2025.06.006.

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20

Homma, Yasuhiro, Takuma Yamasaki, Ken Tashiro, et al. "Autologous concentrated bone marrow injection for precollapse osteonecrosis of the femoral head concurrent with contralateral total hip arthroplasty: protocol for a clinical trial." BMJ Open 14, no. 5 (2024): e082243. http://dx.doi.org/10.1136/bmjopen-2023-082243.

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IntroductionThe femoral head contralateral to the collapsed femoral head requiring total hip arthroplasty (THA) often manifests in the precollapse stage of osteonecrosis of the femoral head (ONFH). It is not yet demonstrated how autologous concentrated bone marrow injection may prevent collapse of the femoral head concurrent with contralateral THA. The primary objective is to evaluate the efficacy of autologous concentrated bone marrow injection for the contralateral, non-collapsed, femoral head in patients with bilateral ONFH, with the ipsilateral collapsed femoral head undergoing THA.Methods

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21

Sasai, Masao, Mina Okamoto, Shunsuke Tanigawa, Satoshi Okada, Daisuke Sugiyama, and Akira Myoui. "Remote audit practice for inspection of structural and equipment standards for cell processing facilities under the act on the safety of regenerative medicine in Japan." Regenerative Therapy 25 (March 2024): 85–91. http://dx.doi.org/10.1016/j.reth.2023.12.001.

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22

Sibiak, Rafał, Katarzyna Stefańska, Kornel Ratajczak, et al. "Recent findings on perinatal mesenchymal stem cells – their possible application in current advanced medicine." Medical Journal of Cell Biology 9, no. 2 (2021): 48–55. http://dx.doi.org/10.2478/acb-2021-0008.

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Abstract The mature human placenta and umbilical cord are rich sources of perinatal mesenchymal stem cells (MSCs). Both cell populations have similar characteristics and cellular properties. Each population can differentiate into multiple mesenchymal subpopulations and retain their self-renewal capacities. Perinatal stem cells can be isolated from tissues obtained from the planned cesarean sections and vaginal deliveries. Their isolation is relatively easy, making them readily available for implementation in various in vitro studies and clinical trials. Their differentiation abilities could be

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23

張凱鑫, 張凱鑫. "再生醫療製劑之附附款許可制度——以日本藥機法為比較對象". 月旦醫事法報告 80, № 80 (2023): 019–31. http://dx.doi.org/10.53106/241553062023060080002.

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24

Berta, Lavinia, Năstaca-Alina Coman, Aura Rusu, and Corneliu Tanase. "A Review on Plant-Mediated Synthesis of Bimetallic Nanoparticles, Characterisation and Their Biological Applications." Materials 14, no. 24 (2021): 7677. http://dx.doi.org/10.3390/ma14247677.

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The study of bimetallic nanoparticles (BNPs) has constantly been expanding, especially in the last decade. The biosynthesis of BNPs mediated by natural extracts is simple, low-cost, and safe for the environment. Plant extracts contain phenolic compounds that act as reducing agents (flavonoids, terpenoids, tannins, and alkaloids) and stabilising ligands moieties (carbonyl, carboxyl, and amine groups), useful in the green synthesis of nanoparticles (NPs), and are free of toxic by-products. Noble bimetallic NPs (containing silver, gold, platinum, and palladium) have potential for biomedical appli

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25

Geng, Jingping, Xiangli Guo, Lidan Wang, et al. "Intracellular Delivery of DNA and Protein by a Novel Cell-Permeable Peptide Derived from DOT1L." Biomolecules 10, no. 2 (2020): 217. http://dx.doi.org/10.3390/biom10020217.

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Cellular uptake and intracellular release efficiency of biomacromolecules is low because of hurdles in the cell membrane that result in limited access to intra-cellular targets with few functional effects. Cell-penetrating peptides (CPPs) act as cargo delivery vehicles to promote therapeutic molecule translocation. Here, we describe the novel CPP-Dot1l that not only penetrates by itself, but also mediates cargo translocation in cultured cells, as confirmed by fluorescence microscopy and fluorescence spectrophotometry. We conducted cytotoxicity assays and safety evaluations, and determined pept

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26

Fernandes, Fiona, Pooja Kotharkar, Adrija Chakravorty, Meenal Kowshik, and Indrani Talukdar. "Nanocarrier Mediated siRNA Delivery Targeting Stem Cell Differentiation." Current Stem Cell Research & Therapy 15, no. 2 (2020): 155–72. http://dx.doi.org/10.2174/1574888x14666191202095041.

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Stem cell-based regenerative medicine holds exceptional therapeutic potential and hence the development of efficient techniques to enhance control over the rate of differentiation has been the focus of active research. One of the strategies to achieve this involves delivering siRNA into stem cells and exploiting the RNA interference (RNAi) mechanism. Transport of siRNA across the cell membrane is a challenge due to its anionic property, especially in primary human cells and stem cells. Moreover, naked siRNA incites immune responses, may cause off-target effects, exhibits low stability and is e

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27

Shivam Rongpi, Injamul Islam, Ananta Choudhury, and Charlisar Teron. "Unraveling the Frontiers of Nanomedicine: Exploring Advancements and Envisioning the Future." Asian Journal of Pharmaceutical Research and Development 12, no. 4 (2024): 126–32. http://dx.doi.org/10.22270/ajprd.v12i4.1452.

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Nanomedicine is an emerging field at the junction of nanotechnology and medicine that provides high-order therapeutic solutions for different diseases. This review discusses the latest developments and future directions in nanomedicine applications in diverse areas of drug delivery, diagnostics, and tissue regeneration.Nanoparticles are engineered at the nanoscale level and, hence, play a very significant role in targeted drug delivery, improving the efficacy of drugs with reduced side effects. This has resulted in recent developments that include the functionalization of nanoparticles that ca

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28

Laurent, Alexis, Corinne Scaletta, Philippe Abdel-Sayed, Wassim Raffoul, Nathalie Hirt-Burri, and Lee Ann Applegate. "Primary Progenitor Tenocytes: Cytotherapeutics and Cell-Free Derivatives." Encyclopedia 3, no. 1 (2023): 340–61. http://dx.doi.org/10.3390/encyclopedia3010021.

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Primary progenitor tenocytes are diploid cells that may be cultured in vitro and therapeutically used for allogeneic musculoskeletal regenerative medicine. Firstly, technical aspects of cell banking, biotechnological manufacturing, and extensive preclinical characterization data have confirmed that FE002-Ten primary progenitor tenocytes may be safely considered for human cytotherapeutic use (e.g., in tissue engineering products, standardized transplants). Parallelly, lyophilized progenitor tenocyte extracts (e.g., stabilized cells or cell-free derivatives) were shown to optimally act as potent

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Aziz-Andersen, Kaiser J. "Stem-cells Research and Therapies." Journal of Drug Delivery and Therapeutics 14, no. 2 (2024): 244–46. http://dx.doi.org/10.22270/jddt.v14i2.6413.

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Studies with leucogenenol, a compound isolated from the metabolic products of Penicillium gilmanii and human liver showed that leucogenenol accelerated the rate at which the “functional” cells, neutrophils, red blood cells and lymphocytes developed in the bone marrow from their corresponding committed precursor cells. It was found that the neutrophils that appear in the peripheral blood circulation following injection of leucogenenol originated from the neutrophils in the bone marrow. A scheme was presented to show that leucogenenol and adroxazine play key roles in regulating the circulation o

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Szubarga, Alicja, Marta Kamińska, Wiktoria Kotlarz, et al. "Human stem cells – sources, sourcing and in vitro methods." Medical Journal of Cell Biology 9, no. 2 (2021): 73–85. http://dx.doi.org/10.2478/acb-2021-0011.

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Abstract Stem cells are an important subject of research, and are increasingly used in the treatment of various diseases. Due to the development of advanced in vitro techniques, they have become an integral part of modern medicine. The sources of human stem cells are primarily bone marrow and adipose tissue, although non – embryonic stem cells are also scattered throughout the body. Notably, recent research has focused on stem cells found in the oral cavity, both in the dental pulp and oral mucosa. Furthermore, isolation of stem cells from umbilical cord blood is also becoming increasingly pop

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31

Atkinson, Lloyd, Francesca Martin, and Roger G. Sturmey. "Intraovarian injection of platelet-rich plasma in assisted reproduction: too much too soon?" Human Reproduction 36, no. 7 (2021): 1737–50. http://dx.doi.org/10.1093/humrep/deab106.

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Abstract The prospect of ovarian rejuvenation offers the tantalising prospect of treating age-related declines in fertility or in pathological conditions such as premature ovarian failure. The concept of ovarian rejuvenation was invigorated by the indication of the existence of oogonial stem cells (OSCs), which have been shown experimentally to have the ability to differentiate into functional follicles and generate oocytes; however, their clinical potential remains unknown. Furthermore, there is now growing interest in performing ovarian rejuvenation in situ. One proposed approach involves in

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32

Park, So-Yeon, Da-Seul Kim, Hyun-Mun Kim, et al. "Human Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Neural Differentiation of Neural Progenitor Cells." International Journal of Molecular Sciences 23, no. 13 (2022): 7047. http://dx.doi.org/10.3390/ijms23137047.

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Mesenchymal stem cells (MSCs) have been adopted in various preclinical and clinical studies because of their multipotency and low immunogenicity. However, numerous obstacles relating to safety issues remain. Therefore, MSC-derived extracellular vesicles (EVs) have been recently employed. EVs are nano-sized endoplasmic reticulum particles generated and released in cells that have similar biological functions to their origin cells. EVs act as cargo for bioactive molecules such as proteins and genetic materials and facilitate tissue regeneration. EVs obtained from adipose-derived MSC (ADMSC) also

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33

Sugimoto, Naoshi, Junya Kanda, Sou Nakamura, et al. "The First-in-Human Clinical Trial of iPSC-Derived Platelets (iPLAT1): Autologous Transfusion to an Aplastic Anemia Patient with Alloimmune Platelet Transfusion Refractoriness." Blood 138, Supplement 1 (2021): 351. http://dx.doi.org/10.1182/blood-2021-145814.

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Abstract Introduction: Platelet transfusion have saved lives of patients with thrombocytopenia through preventing or treating bleeding complications. Currently, platelet products are provided from blood banks which collect blood from healthy donors. However, our ageing society bears the risk of supply in the future. Furthermore, although the rate is decreasing, alloimmune platelet transfusion refractoriness (allo-PTR) is still found in 5% of platelet transfusion patients. Gestation and previous platelet transfusion cause sensitization to produce alloantibodies mostly against class I human leuk

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34

Dave, Riya Divyakant. "Scaling down for better periodontal health: The role of nanotechnology." IP International Journal of Periodontology and Implantology 8, no. 1 (2023): 56–58. http://dx.doi.org/10.18231/j.ijpi.2023.011.

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Nanotechnology has emerged as a promising approach in the treatment of periodontal diseases, which affect a large proportion of the population worldwide. By studying nanotechnology, we can gain a better understanding of how these materials can be used in daily practice. Nanotechnology involves the development of materials, devices, and systems that exhibit unique physical, chemical, and biological properties at the nanoscale level. This technology has the potential to revolutionize the prevention, diagnosis, and treatment of oral diseases, including periodontal disease, which affects a signifi

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35

Ekhilevskiy, S. G., O. V. Golubeva, and E. P. Potapenko. "Probability-theoretic Approach to Modeling a Respirator on Chemically Bound Oxygen." Occupational Safety in Industry, no. 10 (October 2020): 7–15. http://dx.doi.org/10.24000/0409-2961-2020-10-7-15.

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At present, the main prospects for improving the insulating means of respiratory protection are related to the chemical method of oxygen reservation. The arguments in favor of this choice are the high density of oxygen packaging and its self-regulating supply, depending on the physical activity of the person. Usually, the working process in devices on chemically bound oxygen is modeled using mathematical physics methods that solve the so-called sorption dynamics problem. As a result, under given boundary and initial conditions, the concentration of CO2 molecules in the regenerative cartridge t

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Ekhilevskiy, S. G., O. V. Golubeva, O. N. Zabelendik, and E. P. Potapenko. "Correlation Relationship and Asymptotics of the Sorption Dynamics in the Regenerative Cartridge of the Insulating Respirator." Occupational Safety in Industry, no. 7 (July 2022): 22–28. http://dx.doi.org/10.24000/0409-2961-2022-7-22-28.

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Usually, to simulate the operation of an insulating respirator, the problem of sorption dynamics is solved. The result obtained under the given initial and boundary conditions uniquely describes the evolution of impurity breakthrough through the filter. However, the coordinate of the elementary act of sorption is reliably unpredictable. Therefore, a probability-theoretic approach to modeling the workflow of an insulating respirator on chemically bound oxygen is possible. This publication is devoted to its further development. An additional powerful resource is connected to the modeling of sorp

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37

Helmlinger, Connie. "PATIENT SAFETY ACT." American Journal of Nursing 96, no. 10 (1996): 24. http://dx.doi.org/10.1097/00000446-199610000-00036.

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Helmlinger, Connie. "PATIENT SAFETY ACT." American Journal of Nursing 96, no. 11 (1996): 22. http://dx.doi.org/10.1097/00000446-199611000-00031.

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Helmlinger, Connie. "PATIENT SAFETY ACT." American Journal of Nursing 97, no. 3 (1997): 16. http://dx.doi.org/10.1097/00000446-199703000-00010.

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&NA;. "PATIENT SAFETY ACT." American Journal of Nursing 97, no. 4 (1997): 16. http://dx.doi.org/10.1097/00000446-199704000-00010.

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Kim, Hyeon Cheol, and Erei Yoon. "Issues in the Introduction of the Advanced Regenerative Medicine Act." LAW RESEARCH INSTITUTE CHUNGBUK NATIONAL UNIVERSITY 10, no. 1 (2019): 39–64. http://dx.doi.org/10.34267/cbstl.2019.10.1.39.

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42

Eissner, Günther. "Mesenchymal Stromal Cells “Think” Globally, but Act Locally." Cells 12, no. 3 (2023): 509. http://dx.doi.org/10.3390/cells12030509.

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In this Special Issue of Cells, entitled “Immunomodulation by Mesenchymal Stem Cells 2020”, you can find five excellent papers on the role of mesenchymal stem/stromal cells (MSCs) in immunomodulation, which also includes regenerative processes, such as wound healing [...]

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Marks, Peter, and Scott Gottlieb. "Balancing Safety and Innovation for Cell-Based Regenerative Medicine." New England Journal of Medicine 378, no. 10 (2018): 954–59. http://dx.doi.org/10.1056/nejmsr1715626.

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44

Tkach, Jeff. "Regenerative Health Initiatives: Developments and Opportunities." Alternative and Complementary Therapies 27, no. 2 (2021): 66–67. http://dx.doi.org/10.1089/act.2021.29316.jtk.

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45

Mureed, Maryam, Arooj Fatima, Tayyaba Sattar, et al. "The Complementary Roles of Neurological and Musculoskeletal Physical Therapy and Regenerative Medicine: A Comprehensive Review." Medicina 60, no. 7 (2024): 1062. http://dx.doi.org/10.3390/medicina60071062.

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Regenerative medicine, encompassing various therapeutic approaches aimed at tissue repair and regeneration, has emerged as a promising field in the realm of physical therapy. Aim: This comprehensive review seeks to explore the evolving role of regenerative medicine within the domain of physical therapy, highlighting its potential applications, challenges, and current trends. Researchers selected publications of pertinent studies from 2015 to 2024 and performed an exhaustive review of electronic databases such as PubMed, Embase, and Google Scholar using the targeted keywords “regenerative medic

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Rothoerl, Ralf, Junee Tomelden, and Eckhard Udo Alt. "Safety and Efficacy of Autologous Stem Cell Treatment for Facetogenic Chronic Back Pain." Journal of Personalized Medicine 13, no. 3 (2023): 436. http://dx.doi.org/10.3390/jpm13030436.

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Background: Chronic back pain due to facet joint syndrome is a common and debilitating condition. Advances in regenerative medicine have shown that autologous unmodified adipose tissue-derived regenerative cells (ADRC) provide several beneficial effects. These regenerative cells can differentiate into various tissues and exhibit a strong anti-inflammatory potential. ADRCs can be obtained from a small amount of fatty tissue derived from the patient’s abdominal fat. Methods: We report long-term results of 37 patients (age 31–78 years, mean 62.5) suffering from “Facet Joint Syndrome” The patholog

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Green, Eric M., and Richard T. Lee. "Proteins and Small Molecules for Cellular Regenerative Medicine." Physiological Reviews 93, no. 1 (2013): 311–25. http://dx.doi.org/10.1152/physrev.00005.2012.

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Regenerative medicine seeks to understand tissue development and homeostasis and build on that knowledge to enhance regeneration of injured tissues. By replenishing lost functional tissues and cells, regenerative medicine could change the treatment paradigm for a broad range of degenerative and ischemic diseases. Multipotent cells hold promise as potential building blocks for regenerating lost tissues, but successful tissue regeneration will depend on comprehensive control of multipotent cells–differentiation into a target cell type, delivery to a desired tissue, and integration into a durable

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48

Hermerén, Göran. "The ethics of regenerative medicine." Biologia Futura 72, no. 2 (2021): 113–18. http://dx.doi.org/10.1007/s42977-021-00075-3.

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AbstractMost developments in regenerative medicine have in common that there are many uncertainties and knowledge gaps. These features make the evaluation of long-term consequences of the available options difficult and have consequences for the ethical issues raised. This paper presents an overview of ethical issues raised in regenerative medicine, using as a starting point a list of stakeholders and their interests. Ethical issues are introduced via a simplified account of a project that focuses on several difficult problems, as well as a conceptual framework consisting of the following key

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ADEDOKUN, Issa Akanji, Temidayo Peter AKEREDOLU, and Olowo-Niyi ADEBOLA. "THE ROLE OF INTELLECTUAL PROPERTY IN THE DEVELOPMENT OF INNOVATIONS IN REGENERATIVE MEDICINE." ABUAD Law Journal 12, no. 1 (2024): 84–103. http://dx.doi.org/10.53982/alj.2024.1201.05-j.

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Regenerative medicine marks a paradigm shift in healthcare, transitioning from symptom-based treatment to leveraging the body's inherent healing mechanisms. It represents a convergence of nature and science, fostering innovative solutions for preserving life. Intellectual Property (IP) safeguards the expression of innovation and creativity across various domains, encompassing regenerative medicine. However, questions arise regarding its ability to meet patentability criteria and the ethical implications of granting exclusive ownership (Intellectual Property) to life-saving techniques, potentia

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Gumeniuk, M. I. "Regenerative medicine: going beyond transplantology." Infusion & Chemotherapy, no. 4 (December 28, 2022): 6–13. http://dx.doi.org/10.32902/2663-0338-2022-4-6-13.

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Since the possibilities of transplantology are limited, there is a need for tissue engineering and regenerative medicine (RM). Several high-tech approaches are used in RM: the use of soluble molecules, gene therapy, stem cell transplantation, tissue engineering, reprogramming of cells and tissues, etc. As an important component, RM strategies include innovative materials that can imitate the extracellular matrix of tissues, influencing the behavior of cells and regulating the structure and function of the formed tissue, for example, 3D polymer scaffolds, bioglass grafts, and nanofiber meshes.

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