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Dissertations / Theses on the topic 'Actin'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Wang, Hui. "Structural studies of actin and actin-binding proteins." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/10916.

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Actin is involved in cell movement, maintaining cell shape and anchoring cytoskeletal proteins. These functions are regulated by many actin-binding proteins, including those of the gelsolin superfamily. Gelsolin superfamily members regulate actin organization by severing, capping F-actin, nucleating the formation of F-actin and/or bundling F-actin. Although abundant structures are available for gelsolin and gelsolin fragments in complexes with actin, the detailed mechanisms for gelsolin activation, and for gelsolin severing and capping of F-actin are still unknown. Structures for gelsolin fami

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2

Hull, Richard Alan. "Actin and actin-binding proteins in higher plants." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.279874.

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3

Heisler, David Bruce. "Role of Actin and Actin-binding Proteins in the Pathogenesis of Actin-targeting Bacterial Toxins." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1501519777175964.

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4

Gholami, Azam. "Actin-based motility." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-72151.

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5

Yeoh, Sharon I.-Wen. "Molecular interactions of human actin depolymerizing factor and cofilin with actin." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621255.

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6

Gallinger, Julia. "WH2 domains and actin variants as multifunctional organizers of the actin cytoskeleton." Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-161698.

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Actin is one of the most abundant proteins in eukaryotic cells and regulation of the microfilament system is crucial for a wide range of cellular functions including cell shape, cell motility, cell division and membrane dynamics. The aim of this thesis was (1) to gain a better understanding of the function of distinct actin binding domains in the regulation of the actin cytoskeleton and (2) to elucidate the role of actin variants. WH2 domains (WH2, Wiskott-Aldrich syndrome protein homology 2) are ubiquitous multifunctional regulators of actin dynamics. The protein Spire contains four central

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7

Broderick, Michael James Francis. "The utrophin-actin interface." Thesis, University of Glasgow, 2005. http://theses.gla.ac.uk/30889/.

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The spectrin superfamily is a diverse group of proteins variously involved in cross- linking, bundling and binding to the F-actin cytoskeleton. These proteins are modular in nature and interaction with actin occurs, at least in part, via CH domain containing ABDs. The actin binding domains of the spectrin superfamily proteins are all very similar in overall structure however the functions of the individual proteins differ greatly. Utrophin is a member of the spectrin superfamily and has been used extensively to investigate and model the association of actin-binding domains with F- actin; howev

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8

McGrath, James L. (James Lionel). "Actin dynamics in the cell cytoplasm and the role of actin associated proteins." Thesis, Massachusetts Institute of Technology, 1998. http://hdl.handle.net/1721.1/50446.

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9

Singh, Anish D. "Regulation and function of the non-muscle [beta]-actin and [gamma]-actin genes." Phd thesis, Department of Paediatrics and Child Health, Faculty of Medicine, 2004. http://hdl.handle.net/2123/11556.

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10

Kruth, Karina Annette. "Effects of three deafness-causing gamma-actin mutations on actin structure and function." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/1475.

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Hearing requires proper function of the auditory hair cell, which is critically dependent upon its actin-based cytoskeletal structure. Eleven point mutations in gamma (γ) nonmuscle actin have been identified as causing progressive autosomal dominant nonsyndromic hearing loss (DFNA20/26); however, exactly why these mutations lead to deafness is unclear. Organization, stability, and repair of the hair cell cytoskeleton are highly regulated by actin binding proteins (ABPs), and two of the mutations, K118M and K118N, are located near an area of the actin monomer believed to be important in actin-A

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11

Hayot, Caroline. "Mise au point d'une stratégie pharmacologique originale pour l'obtention de composés anti-cancéreux anti-migratoires." Doctoral thesis, Universite Libre de Bruxelles, 2006. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210860.

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La migration cellulaire est une étape clé intervenant à un stade précoce de la dissémination des cellules cancéreuses dans l’organisme, et est donc responsable de la formation des métastases qui tuent environ nonante pourcent des patients atteints de cancer. De plus, ces cellules migrantes résistent à l’apoptose grâce à l’activation constitutive de voies de signalisation anti-apoptotiques, et développent donc une résistance vis-à-vis des traitements anti-cancéreux actuels qui sont généralement pro-apoptotiques. Nous avons pris pour cible ce processus de migration cellulaire dans l’espoir d’ide

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12

Storz, Tobias-Alexander. "Statische und dynamische Lichtstreuung an Lösungen von Aktinfilamenten." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=963434861.

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13

Glenz, Martin H. "Heterodimere F-actin capping proteine." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=981289509.

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14

Osborn, Eric A. (Eric Alan) 1975. "Actin remodeling in motile cells." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/28600.

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Thesis (Ph. D.)--Harvard-MIT Division of Health Sciences and Technology, 2004.<br>Includes bibliographical references.<br>Non-muscle cell shape change and motility depend primarily on the dynamics and distributions of cytoplasmic actin. In cells, actin cycles between monomeric and polymeric phases tightly regulated by actin binding proteins that control cellular architecture and movement. Here, we characterize actin remodeling in shear stress stimulated endothelial cells and in actin networks reconstituted with purified proteins. Fluid shear stress stimulation induces endothelial cells to elon

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15

McGrath, James L. (James Lionel). "Measuring actin dynamics in endothelium." Thesis, Massachusetts Institute of Technology, 1994. http://hdl.handle.net/1721.1/38015.

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16

Ahrens, S. "Extracellular actin in innate immunity." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1433762/.

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The innate immune system is capable of responding to tissue injury by detecting the abnormal exposure of intracellular, often ubiquitously expressed, molecules referred to as damage-associated molecular patterns (DAMPs). DAMPs are normally sequestered inside healthy cells but become exposed to the extracellular environment upon loss of membrane integrity during cell death. Exposed DAMPs are then recognised by receptors of the innate immune system. One such DAMP receptor is DNGR-1 (CLEC9A), which is expressed on CD8+ DCs, a rare but specialised subset of DCs involved in regulating T cell respon

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17

Marzook, Noorul Bishara. "Lights, Camera, Actin: Divergent roles of beta- and gamma-cytoplasmic actin in vaccinia virus infection." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/16859.

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Intracellular pathogens require access to host cells for their replication and spread. The host actin cytoskeleton represents a physical barrier to them, although many have evolved ways to circumvent, or hijack, this system to their advantage. Vaccinia virus (VACV) can manipulate the host actin cytoskeleton to facilitate dissemination. It expedites its cellular egress by nucleating actin beneath its particles, creating filamentous actin (F-actin) comets that propel virions across the cell surface. Tagging VACV proteins with fluorescent markers is used to study virus-host interactions, and de

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18

Ferrer, Jorge M. 1976. "Mapping the actin and actin binding proteins interactions : from micromechanics to single molecule force spectroscopy." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/40950.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Biological Engineering Division, 2007.<br>Includes bibliographical references.<br>Mechanical forces play an important role in cell morphology, orientation, migration, adhesion and can even induce apoptosis. The eukaryotic cell is equipped with a dynamic frame, known as the cytoskeleton, that provides the cell's structural integrity in order to sustain and react to such forces. Therefore, understanding the mechanical properties of the cytoskeleton is an important step towards building models describing cell behavior. Filamentous actin (F-a

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19

Sofia, Denise Michela. "Characterization of profilin and actin depolymerizing factors expression and function in the testis." [S.l. : s.n.], 2006. http://nbn-resolving.de/urn:nbn:de:bsz:16-opus-76643.

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20

Jeffries, T. E. "The use of pyrene-labelled actin to investigate the interaction between actin and other muscle proteins." Thesis, University of Bristol, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384441.

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21

Wear, Martin Alexander. "Biochemical studies on gelsolin : actin complexes and experiments to form a minimal, defined-length actin filament." Thesis, University of Edinburgh, 2000. http://hdl.handle.net/1842/23253.

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In this thesis we report the formation of a putative "capped-actin-minifilament" complex. This was created by combining the gelsolin:actin<sub>2</sub> ternary (G:A<sub>2</sub>) and the actin:DNaseI binary (A:D) complexes together (1:1 molar ratio) under polymerising conditions (100mM KC1; 2mM MgC1<sub>2</sub> in the presence of 0.2mM CaC1<sub>2</sub>). Size-exclusion data indicates the formation of a significantly larger species (in relation to G:A<sub>2</sub>), with an apparent stiochiometry of G:A<sub>3</sub>:D (gelsolin:actin:DNaseI, respectively). Kinetic and modelling evidence (Weber et a

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22

Matthews, Jermey N. A. "Thermodynamics and relaxation during actin polymerization." College Park, Md. : University of Maryland, 2005. http://hdl.handle.net/1903/2346.

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Thesis (Ph. D.) -- University of Maryland, College Park, 2005.<br>Thesis research directed by: Chemical Engineering. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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23

Moniz, de Sa Mario. "The evolution of angiosperm actin genes." Thesis, University of Ottawa (Canada), 1995. http://hdl.handle.net/10393/10062.

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Forty-four actin genes from five angiosperm species, whose evolutionary relationships are well characterized, were PCR-cloned and sequenced. Phylogenetic analysis of 34 of these actin genes, along with those previously published, indicate that plant actin genes are monophyletic and underwent a rapid radiation early in land plant evolution. Six sets of putative orthologues have been identified and their sequences were used to calculate rates of evolution. The synonomous rate of substitution $(5.44\times10\sp{-9}$/site/year) is similar to that of other nuclear protein-encoding genes but the non-

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24

Niedermayer, Thomas. "On the depolymerization of actin filaments." Phd thesis, Universität Potsdam, 2012. http://opus.kobv.de/ubp/volltexte/2013/6360/.

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Actin is one of the most abundant and highly conserved proteins in eukaryotic cells. The globular protein assembles into long filaments, which form a variety of different networks within the cytoskeleton. The dynamic reorganization of these networks - which is pivotal for cell motility, cell adhesion, and cell division - is based on cycles of polymerization (assembly) and depolymerization (disassembly) of actin filaments. Actin binds ATP and within the filament, actin-bound ATP is hydrolyzed into ADP on a time scale of a few minutes. As ADP-actin dissociates faster from the filament ends than

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25

Thangavelu, Madan. "The actin gene family of tobacco." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335212.

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26

Begg, Carolyn E. "Studies of mouse actin genomic clones." Thesis, University of Glasgow, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280030.

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27

Carrel, Hyman A. (Hyman Andrew) 1979. "Giant vesicles compressed by actin polymerization." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/16646.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Physics, 2004.<br>Includes bibliographical references (p. 45-46).<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Actin polymerization plays a critical role in generating propulsive force to drive many types of cell motility. The discovery of actin based motility of the bacterial pathogen Listeria monocytogenes has lead to clearer understandings of the essential ingredients required for cell motility. The biophysical mechanisms

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28

Shin, Jennifer Hyunjong 1974. "Dynamics and statics of actin assemblies." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/27043.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2004.<br>Includes bibliographical references (p. 95-101).<br>The conversion of chemical energy into mechanical forces that powers cell movements is a ubiquitous theme across biology. The acrosome reaction of Limulus sperm is a simple example of such a dynamical transformation where a 60 [mu]m-long crystalline bundle of actin filaments, tightly cross-linked by actin bundling protein scruin, straightens from a coiled conformation and extends from the cell in five seconds. This spring-like mechanism represent

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29

Lee, Hyungsuk. "Mechanical properties of F-actin network." Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/50588.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2009.<br>Includes bibliographical references.<br>Cells sense, generate and respond to forces in their surroundings through cytoskeletal dynamics. Actin, the most abundant protein found in eukaryotic cells, is organized into various cytoskeletal structures that provide physical support for the cell and play important roles in numerous cellular processes. Assembly of F-actin into higher-order structures is regulated by over 100 actin binding proteins (ABPs). Although extensive measurements to estimate the me

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30

Robertson, Alec 1974. "Material properties of actin filament bundles." Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/46628.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2009.<br>Includes bibliographical references (p. 119-127).<br>Actin is an ubiquitous structural protein fundamental to such biological processes as cell motility and muscle contraction. Our model system is the acrosomal process of the Limulus sperm which extends a 60 ýtm long actin bundle during reproduction. It is an example of a biological spring where the force of elongation derives from twist energy stored within the bundle during spermatogenesis. In addition to actin the acrosome comprises only one ot

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31

Brown, Jennifer. "Investigating the actin cytoskeleton in cancer." Thesis, University of Glasgow, 2016. http://theses.gla.ac.uk/7266/.

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Dynamic alterations in the actin cytoskeleton, under the regulation of the Rho/ROCK pathway, permit cell motility, cell-to-cell and cell-to-matrix adhesion, and have also been shown to participate in apoptosis and cell proliferation. These facets of cellular behaviour all have the capacity to become dysregulated in cancer; components of the Rho/ROCK pathway are known to play varying roles in these processes, both within primary tumours and within the tumour microenvironment. The LIM kinases are phosphorylated and activated by ROCK, leading to inactivation of cofilin and subsequent stabilisatio

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32

Lieleg, Oliver. "Model systems of the actin cortex." kostenfrei, 2008. http://mediatum2.ub.tum.de/doc/672641/672641.pdf.

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33

Scoville, Damon Charles. "Filament dynamics and actin binding factors." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1693066541&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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34

Hu, Xiaohua. "Actin polymerization dynamics at the leading edge." Diss., Virginia Tech, 2012. http://hdl.handle.net/10919/39940.

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Actin-based cell motility plays crucial role throughout the lifetime of an organism. While the dendritic nucleation model explains the initiation and organization of the actin network in lamellipodia, two questions need to be answered. In this study, I reconstructed cellular motility in vitro to investigate how actin filaments are organized to coordinate elongation and attachment to leading edge. Using total internal reflection fluorescence microscopy of actin filaments, we tested how profilin, Arp2/3, and capping protein (CP) function together to propel beads or thin glass nanofibers coated w

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35

Gallinger, Julia [Verfasser], and Michael [Akademischer Betreuer] Schleicher. "WH2 domains and actin variants as multifunctional organizers of the actin cytoskeleton / Julia Gallinger. Betreuer: Michael Schleicher." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2013. http://d-nb.info/1043906355/34.

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36

Buencamino, Raphael Hector Domingo. "Novel roles of actin binding proteins in Listeria monocytogenes actin-based motility revealed within a cellular context." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3297798.

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37

Uhde, Jörg. "Mikrorheometrie passiver und aktiver Aktinnetzwerke." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972234802.

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38

Baroni, Luciana. "Caracterização molecular da actina do Apicomplexa Neospora caninum." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/60/60135/tde-25022013-103829/.

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Neospora caninum é um protozoário pertencente ao filo Apicomplexa que atinge, dentre diversos hospedeiros intermediários, principalmente bovinos e tem emergido como um importante causador de problemas reprodutivos e abortos em rebanhos de corte e leiteiro. Organismos do filo Apicomplexa são parasitas intracelulares obrigatórios que, para locomoverem-se e realizarem a invasão das células hospedeiras, utilizam um mecanismo próprio de locomoção ativa impulsionada pelo motor actina/miosina denominado motilidade por deslizamento (gliding motility), cujo complexo motor localiza-se entre a membrana p

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39

Wang, Hong. "Regulation of actin polymerization by cell-matrix adhesion complexes : a biochemical study of the talin-vinculin complex Integrin-bound talin head inhibits actin filament barbed-end elongation Talin and vinculin combine their individual activities to trigger actin assembly The C-terminal domain of EFA6A interacts directly with F-actin and assembles F-actin bundles." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASS132.

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Pour migrer efficacement dans différents tissus, les cellules doivent détecter et s'adapter aux variations des propriétés mécaniques de leur environnement. Dans ce processus d’adaptation, les adhérences focales (AF) renforcent leur lien avec la matrice extracellulaire et le cytosquelette d'actine. En réponse à la force, l'association de la taline et de la vinculine pourrait renforcer l'ancrage de l'actine aux AF en contrôlant l'assemblage de l'actine par un mécanisme inconnu. Des études antérieures ont montré que la vinculine contient un seul domaine de liaison à l'actine (ABD) qui lie les fil

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40

Badaoui, Magid. "Multi-scale analysis of the mechanics of branched actin material." Electronic Thesis or Diss., Université Paris Cité, 2023. http://www.theses.fr/2023UNIP7074.

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La polymérisation de filaments d'actine contre une membrane peut générer des forces importantes entraînant l'endocytose chez la levure ou la formation de lamellipodes à l'extrémité de cellules motiles comme les kératocytes. Cette polymérisation est thermodynamiquement favorable car l'ajout d'un monomère s'accompagne d'une diminution du potentiel chimique. Cependant, la croissance du filament ralentie lorsqu'une contrainte lui est opposée, évaluant la force de décrochage à quelques pN. Si ce schéma est bien établi pour un filament unique, il n'est pas évident de le transposer à un réseau compos

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41

Huber, Florian. "Emergent structure formation of the actin cytoskeleton." Doctoral thesis, Universitätsbibliothek Leipzig, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-86666.

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Anders als menschengemachte Maschinen verfügen Zellen über keinen festgeschriebenen Bauplan und die Positionen einzelner Elemente sind häufig nicht genau festgelegt, da die Moleküle diffusiven Zufallsbewegungen unterworfen sind. Darüber hinaus sind einzelne Bauteile auch nicht auf eine einzelne Funktion festgelegt, sondern können parallel in verschiedene Prozesse einbezogen sein. Basierend auf Selbstorganisation und Selbstassemblierung muß die Organisation von Anordnung und Funktion einer lebenden Zelle also bereits in ihren einzelnen Komponenten inhärent enthalten sein. Die intrazelluläre Or

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42

Hsu, C. R. "Characterisation of a Salmonella actin-binding protein." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604683.

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<i>Salmonella</i> invasion protein C (SipC) and SipA bind actin directly. SipC inserts into the host cell plasma membrane from where it promotes effector delivery and is essential for <i>Salmonella</i> invasion. SipC-C (residues 200-409) directly nucleates actin polymerisation <i>in vitro</i> and induces cytoskeletal rearrangements at the leading edge when expressed in cells. By analysis a panel of SipC-C derivatives in transfected cells, a region spanning residues 377-409 was defined as necessary for actin reorganisation and leading-edge localisation. Residues 377-409 were sufficient to local

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43

Bai, Limiao, and 白利苗. "In silico simulation of actin-based motility." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B46429116.

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44

Schnauß, Jörg. "Self-assembly effects of filamentous actin bundles." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-179722.

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Das Zytoskelett einer eukaryotischen Zelle besteht aus drei Hauptbestandteilen: Aktin, Intermediärfilamenten und Mikrotubuli. Die vorliegende Arbeit beschäftigt sich mit dem Protein Aktin, welches unter physiologischen Bedingungen dynamische Filamente durch Polymerisation ausbildet. Diese Filamente können sowohl in Netzwerken als auch Bündeln angeordnet werden. Diese Anordnungen bilden die Grundlage für eine Vielfalt von Strukturen zur Realisierung diverser zellulärer Funktionen. Konventionell wurde die Ausprägung solcher Strukturen durch zusätzliche Proteine erklärt, welche Aktin beispielswei

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45

Förster, Florian. "Targeting the actin cytoskeleton with natural compounds." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-168914.

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Targeting the cytoskeleton (CSK) of cancer cells offers a valuable strategy in cancer therapy. Whereas drugs which address microtubule CSK such as vinca alkaloids or taxanes are well established in the clinic, compounds binding to the actin CSK are still far away from their therapeutical application. One reason might be the lacking knowledge on their mode of cytotoxicity and moreover their tumor specific mechanism of action. We used the myxobacterial compound Chondramide as a tool to first elucidate the mechanisms of cytotoxicity by actin targeting in different breast cancer cells, namely MC

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46

McAnulty, Ciaron. "Actin gene variability in different porcine breeds." Thesis, University of Nottingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250527.

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47

Murtagh, Michael Stephen. "Electron microscopy of actin and thin filaments." Thesis, University of Leeds, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421969.

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48

Gedge, Lucinda J. E. "Actin in the nuclei of mammalian cells." Thesis, University of Leeds, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400260.

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49

Drouin, Guy. "The evolution of actin genes in potato." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.330216.

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50

Fox, Helen Mary. "Toca-1 driven actin polymerisation at membranes." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/275610.

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Regulation of the actin cytoskeleton is key to cellular function and underlies processes including cell migration, mitosis and endocytosis. Motile cells send out dynamic actin protrusions that enable them to sense and interact with their environment, as well as generating physical forces. Linking of the actin cytoskeleton to the cell membrane is essential for the formation of these protrusions. The proteins that are thought to fulfil such a role have a membrane interacting domain (such as the PH domain in lamellipodin, or I-BAR protein in IRSp53) and a domain which interacts with actin regulat

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