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1

Lin, Honggui, Jianlong Su, Ranjith Kumar Kankala, Mingrong Zeng, Shu-Feng Zhou, and Xuexia Lin. "Using pH-Activable Carbon Nanoparticles as Cell Imaging Probes." Micromachines 10, no. 9 (2019): 568. http://dx.doi.org/10.3390/mi10090568.

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Herein, we demonstrate the fabrication of innovative pH-activable carbon nanoparticles (CNPs) based on urea and citric acid by microwave-assisted green synthesis for application in cell imaging. These CNP-based nanoprobes offer significant advantages of pH responsiveness and excellent biocompatibility. The pH responsiveness ranges from 1.0 to 4.6 and the slightly pH responsiveness ranges from 4.6 to 9.0. In addition, the pH-dependent modification of charge as well as the final diameter of the designed CNPs not only provide support as stable sensors for cell imaging under pH values from 4.6 to
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2

Wang, Yaqin, Wenting Shang, Jianping Xiong, et al. "Activable Nanoparticle for Tumor Aggressiveness and Drug Resistance Prediction by Glutathione Heterogeneous Imaging." Journal of Biomedical Nanotechnology 17, no. 7 (2021): 1339–48. http://dx.doi.org/10.1166/jbn.2021.3124.

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Studies have shown that a higher GSH level is related to more drug-resistant and invasiveness of a tumor. However, it is a great challenge to accurately imaging the GSH level in vivo, for its imaging intensity will interfered by different accumulation of probes in the tumor. Thus, we hypothesized ratiometric photoacoustic imaging that can be used to predict the drug-resistant and invasiveness of tumors by accurate GSH level imaging. In this study, we synthesized MnO2/Indocyanine Green (MnO2/ICG). It can be used as ratiometric photoacoustic (PA) imaging probe, for its absorption at 780 nm (Ab78
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3

L.J. Thorek, D., and J. Grimm. "Enzymatically Activatable Diagnostic Probes." Current Pharmaceutical Biotechnology 13, no. 4 (2012): 523–36. http://dx.doi.org/10.2174/138920112799436339.

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4

Lee, Seulki, Jin Xie, and Xiaoyuan Chen. "Activatable Molecular Probes for Cancer Imaging." Current Topics in Medicinal Chemistry 10, no. 11 (2010): 1135–44. http://dx.doi.org/10.2174/156802610791384270.

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5

More, Lim, Kang, Yun, Yee, and Chang. "Asymmetric and Reduced Xanthene Fluorophores: Synthesis, Photochemical Properties, and Application to Activatable Fluorescent Probes for Detection of Nitroreductase." Molecules 24, no. 17 (2019): 3206. http://dx.doi.org/10.3390/molecules24173206.

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Xanthene fluorophores, including fluorescein, rhodol, and rhodamines, are representative classes of fluorescent probes that have been applied in the detection and visualization of biomolecules. “Turn on” activatable fluorescent probes, that can be turned on in response to enzymatic reactions, have been developed and prepared to reduce the high background signal of “always-on” fluorescent probes. However, the development of activity-based fluorescent probes for biological applications, using simple xanthene dyes, is hampered by their inefficient synthetic methods and the difficulty of chemical
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6

Wang, Hui, Krishna R. Raghupathi, Jiaming Zhuang, and S. Thayumanavan. "Activatable Dendritic 19F Probes for Enzyme Detection." ACS Macro Letters 4, no. 4 (2015): 422–25. http://dx.doi.org/10.1021/acsmacrolett.5b00199.

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7

Lee, Seulki, Kyeongsoon Park, Kwangmeyung Kim, Kuiwon Choi, and Ick Chan Kwon. "Activatable imaging probes with amplified fluorescent signals." Chemical Communications, no. 36 (2008): 4250. http://dx.doi.org/10.1039/b806854m.

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8

Li, Zhen, Caixia Wang, Meng Zhang, Songjiao Li, Zhiqiang Mao, and Zhihong Liu. "Activatable luminescent probes for imaging brain diseases." Nano Today 39 (August 2021): 101239. http://dx.doi.org/10.1016/j.nantod.2021.101239.

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9

Tam, Jenny, Alexander Pilozzi, Umar Mahmood, and Xudong Huang. "Simultaneous Monitoring of Multi-Enzyme Activity and Concentration in Tumor Using a Triply Labeled Fluorescent In Vivo Imaging Probe." International Journal of Molecular Sciences 21, no. 9 (2020): 3068. http://dx.doi.org/10.3390/ijms21093068.

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The use of fluorescent imaging probes that monitor the activity of proteases that experience an increase in expression and activity in tumors is well established. These probes can be conjugated to nanoparticles of iron oxide, creating a multimodal probe serving as both a magnetic resonance imaging (MRI) agent and an indicator of local protease activity. Previous works describe probes for cathepsin D (CatD) and metalloproteinase-2 (MMP2) protease activity grafted to cross-linked iron oxide nanoparticles (CLIO). Herein, we have synthesized a triply labeled fluorescent iron oxide nanoparticle mol
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10

R. Drake, Christopher, David C. Miller, and Ella F. Jones. "Activatable Optical Probes for the Detection of Enzymes." Current Organic Synthesis 8, no. 4 (2011): 498–520. http://dx.doi.org/10.2174/157017911796117232.

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11

Yang, Yanling, and Fan Zhang. "Activatable Chemiluminescent Molecular Probes for Bioimaging and Biosensing." Analysis & Sensing 1, no. 2 (2021): 75–89. http://dx.doi.org/10.1002/anse.202000033.

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12

Miao, Qingqing, and Kanyi Pu. "Emerging Designs of Activatable Photoacoustic Probes for Molecular Imaging." Bioconjugate Chemistry 27, no. 12 (2016): 2808–23. http://dx.doi.org/10.1021/acs.bioconjchem.6b00641.

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13

Texier, Isabelle, Jésus Razkin, Véronique Josserand, et al. "Activatable probes for non-invasive small animal fluorescence imaging." Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 571, no. 1-2 (2007): 165–68. http://dx.doi.org/10.1016/j.nima.2006.10.053.

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14

Carril, Monica. "Activatable probes for diagnosis and biomarker detection by MRI." Journal of Materials Chemistry B 5, no. 23 (2017): 4332–47. http://dx.doi.org/10.1039/c7tb00093f.

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15

Asanuma, Daisuke, Yousuke Takaoka, Shigeyuki Namiki, et al. "Acidic-pH-Activatable Fluorescence Probes for Visualizing Exocytosis Dynamics." Angewandte Chemie 126, no. 24 (2014): 6199–203. http://dx.doi.org/10.1002/ange.201402030.

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16

Lin, Xin, Jin Xie, Lei Zhu, et al. "Hybrid Ferritin Nanoparticles as Activatable Probes for Tumor Imaging." Angewandte Chemie 123, no. 7 (2011): 1607–10. http://dx.doi.org/10.1002/ange.201006757.

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17

Lin, Xin, Jin Xie, Lei Zhu, et al. "Hybrid Ferritin Nanoparticles as Activatable Probes for Tumor Imaging." Angewandte Chemie International Edition 50, no. 7 (2011): 1569–72. http://dx.doi.org/10.1002/anie.201006757.

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18

Asanuma, Daisuke, Yousuke Takaoka, Shigeyuki Namiki, et al. "Acidic-pH-Activatable Fluorescence Probes for Visualizing Exocytosis Dynamics." Angewandte Chemie International Edition 53, no. 24 (2014): 6085–89. http://dx.doi.org/10.1002/anie.201402030.

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19

Sadhu, Kalyan K., Shin Mizukami, Yuichiro Hori, and Kazuya Kikuchi. "Switching Modulation for Protein Labeling with Activatable Fluorescent Probes." ChemBioChem 12, no. 9 (2011): 1299–308. http://dx.doi.org/10.1002/cbic.201100137.

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20

LOVELL, JONATHAN F., and GANG ZHENG. "ACTIVATABLE SMART PROBES FOR MOLECULAR OPTICAL IMAGING AND THERAPY." Journal of Innovative Optical Health Sciences 01, no. 01 (2008): 45–61. http://dx.doi.org/10.1142/s1793545808000157.

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Recent years have seen the design and implementation of many optical activatable smart probes. These probes are activatable because they change their optical properties and are smart because they can identify specific targets. This broad class of detection agents has allowed previously unperformed visualizations, facilitating the study of diverse biomolecules including enzymes, nucleic acids, ions and reactive oxygen species. Designed to be robust in an in vivo environment, these probes have been used in tissue culture cells and in live small animals. An emerging class of smart probes has been
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21

Mochida, Ai, Fusa Ogata, Tadanobu Nagaya, Peter L. Choyke, and Hisataka Kobayashi. "Activatable fluorescent probes in fluorescence-guided surgery: Practical considerations." Bioorganic & Medicinal Chemistry 26, no. 4 (2018): 925–30. http://dx.doi.org/10.1016/j.bmc.2017.12.002.

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22

Nagata, Hiroshi. "Activation of the Antecedent by the Reflexive in Japanese: A Supplementary Control Experiment." Perceptual and Motor Skills 74, no. 1 (1992): 99–106. http://dx.doi.org/10.2466/pms.1992.74.1.99.

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This study is a control experiment for a previous study (Nagata, 1991) that showed activation of an antecedent by a Japanese reflexive, jibun, in syntactically ambiguous sentences. The reflexive involved in the relevant sentences in the previous study was replaced with a word from other parts of speech in this study. This manipulation was done to delete the sentence constituent that might activate any prior antecedent. 24 female students were given a recognition task on which a probe was given either for an indirect object or for a subject either immediately after a replaced word or at the end
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23

Elias, Drew R., Daniel L. J. Thorek, Antony K. Chen, Julie Czupryna, and Andrew Tsourkas. "In vivo imaging of cancer biomarkers using activatable molecular probes." Cancer Biomarkers 4, no. 6 (2008): 287–305. http://dx.doi.org/10.3233/cbm-2008-4602.

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24

Lacivita, E., M. Leopoldo, F. Berardi, N. A. Colabufo, and R. Perrone. "Activatable Fluorescent Probes: A New Concept in Optical Molecular Imaging." Current Medicinal Chemistry 19, no. 28 (2012): 4731–41. http://dx.doi.org/10.2174/092986712803341511.

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25

Li, Jingjing, Fangfang Cheng, Haiping Huang, Lingling Li, and Jun-Jie Zhu. "Nanomaterial-based activatable imaging probes: from design to biological applications." Chemical Society Reviews 44, no. 21 (2015): 7855–80. http://dx.doi.org/10.1039/c4cs00476k.

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26

Swierczewska, Magdalena, Seulki Lee, and Xiaoyuan Chen. "The design and application of fluorophore–gold nanoparticle activatable probes." Physical Chemistry Chemical Physics 13, no. 21 (2011): 9929. http://dx.doi.org/10.1039/c0cp02967j.

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27

Razkin, Jesus, Véronique Josserand, Didier Boturyn, et al. "Activatable Fluorescent Probes for Tumour-Targeting Imaging in Live Mice." ChemMedChem 1, no. 10 (2006): 1069–72. http://dx.doi.org/10.1002/cmdc.200600118.

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28

Gallo, J., N. Vasimalai, M. T. Fernandez-Arguelles, and M. Bañobre-López. "Green synthesis of multimodal ‘OFF–ON’ activatable MRI/optical probes." Dalton Transactions 45, no. 44 (2016): 17672–80. http://dx.doi.org/10.1039/c6dt02840c.

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29

Wang, Steven T., Natalia G. Zhegalova, Tiffany P. Gustafson, et al. "Sensitivity of activatable reactive oxygen species probes by fluorescence spectroelectrochemistry." Analyst 138, no. 15 (2013): 4363. http://dx.doi.org/10.1039/c3an00459g.

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30

Yan, Runqi, and Deju Ye. "Molecular imaging of enzyme activity in vivo using activatable probes." Science Bulletin 61, no. 21 (2016): 1672–79. http://dx.doi.org/10.1007/s11434-016-1175-y.

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31

Zhao, Jing, Guorui Jin, Guojun Weng, Jianjun Li, Jian Zhu, and Junwu Zhao. "Recent advances in activatable fluorescence imaging probes for tumor imaging." Drug Discovery Today 22, no. 9 (2017): 1367–74. http://dx.doi.org/10.1016/j.drudis.2017.04.006.

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32

Zhang, Jingjing, Lukas P. Smaga, Nitya Sai Reddy Satyavolu, Jefferson Chan, and Yi Lu. "DNA Aptamer-Based Activatable Probes for Photoacoustic Imaging in Living Mice." Journal of the American Chemical Society 139, no. 48 (2017): 17225–28. http://dx.doi.org/10.1021/jacs.7b07913.

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33

Zhu, Lei, Ying Ma, Dale O. Kiesewetter, et al. "Rational Design of Matrix Metalloproteinase-13 Activatable Probes for Enhanced Specificity." ACS Chemical Biology 9, no. 2 (2013): 510–16. http://dx.doi.org/10.1021/cb400698s.

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34

Fujioka, Hiroyoshi, Jingwen Shou, Ryosuke Kojima, Yasuteru Urano, Yasuyuki Ozeki, and Mako Kamiya. "Multicolor Activatable Raman Probes for Simultaneous Detection of Plural Enzyme Activities." Journal of the American Chemical Society 142, no. 49 (2020): 20701–7. http://dx.doi.org/10.1021/jacs.0c09200.

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35

Kotagiri, Nalinikanth, Dariusz M. Niedzwiedzki, Kohtaro Ohara, and Samuel Achilefu. "Activatable Probes Based on Distance-Dependent Luminescence Associated with Cerenkov Radiation." Angewandte Chemie International Edition 52, no. 30 (2013): 7756–60. http://dx.doi.org/10.1002/anie.201302564.

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36

Tang, Yufu, Feng Pei, Xiaomei Lu, Quli Fan, and Wei Huang. "Recent Advances on Activatable NIR‐II Fluorescence Probes for Biomedical Imaging." Advanced Optical Materials 7, no. 21 (2019): 1900917. http://dx.doi.org/10.1002/adom.201900917.

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37

Chen, Xueqian, Yongning Bian, Mingrui Li, Yong Zhang, Xueyun Gao, and Dongdong Su. "Activatable Off‐on Near‐Infrared QCy7‐based Fluorogenic Probes for Bioimaging." Chemistry – An Asian Journal 15, no. 23 (2020): 3983–94. http://dx.doi.org/10.1002/asia.202001057.

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38

Kotagiri, Nalinikanth, Dariusz M. Niedzwiedzki, Kohtaro Ohara, and Samuel Achilefu. "Activatable Probes Based on Distance-Dependent Luminescence Associated with Cerenkov Radiation." Angewandte Chemie 125, no. 30 (2013): 7910–14. http://dx.doi.org/10.1002/ange.201302564.

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39

Ding, Shengli, Randall Eric Blue, Yijing Chen, Brooks Scull, Pauline Kay Lund, and Douglas Morgan. "Molecular Imaging of Gastric Neoplasia with Near-Infrared Fluorescent Activatable Probes." Molecular Imaging 11, no. 6 (2012): 7290.2012.00014. http://dx.doi.org/10.2310/7290.2012.00014.

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40

Gong, Liang, Xiuzhi Shan, Xu‐Hua Zhao, Li Tang, and Xiao‐Bing Zhang. "Activatable NIR‐II Fluorescent Probes Applied in Biomedicine: Progress and Perspectives." ChemMedChem 16, no. 16 (2021): 2426–40. http://dx.doi.org/10.1002/cmdc.202100142.

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41

Yao, Yongkang, Yutao Zhang, Chenxu Yan, Wei-Hong Zhu та Zhiqian Guo. "Enzyme-activatable fluorescent probes for β-galactosidase: from design to biological applications". Chemical Science 12, № 29 (2021): 9885–94. http://dx.doi.org/10.1039/d1sc02069b.

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This review highlights the molecular design strategy of β-galactosidase-activatable probes from turn-on mode to ratiometric mode, from ACQ to AIE-active probes, from NIR-I to NIR-II imaging and dual-mode of chemo-fluoro-luminescence imaging.
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42

Opieliński, Krzysztof, Tadeusz Gudra, and Piotr Pruchnicki. "A Digitally Controlled Model of an Active Ultrasonic Transducer Matrix for Projection Imaging of Biological Media." Archives of Acoustics 35, no. 1 (2010): 75–90. http://dx.doi.org/10.2478/v10168-010-0006-4.

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AbstractThe following work presents the idea of constructing a digitally controlled active piezoceramic transducer matrix for ultrasonic projection imaging of biological media in a similar way as in case of roentgenography (RTG). Multielement ultrasonic probes in the form of flat matrices of elementary piezoceramic transducers require attaching a large number of electrodes in order to activate the individual transducers. This paper presents the idea of minimising the number of transducer connections in an active row-column matrix system. This idea was verified by designing a model of a matrix
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43

URANO, Yasuteru. "Sensitive and Selective Tumor Imaging with Novel and Highly Activatable Fluorescence Probes." Analytical Sciences 24, no. 1 (2008): 51–53. http://dx.doi.org/10.2116/analsci.24.51.

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44

Inagaki, Fuyuki F., Daiki Fujimura, Sara Ansteatt, et al. "Effect of Short PEG on Near-Infrared BODIPY-Based Activatable Optical Probes." ACS Omega 5, no. 25 (2020): 15657–65. http://dx.doi.org/10.1021/acsomega.0c01869.

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45

Urano, Yasuteru, Daisuke Asanuma, Yukihiro Hama, et al. "Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes." Nature Medicine 15, no. 1 (2008): 104–9. http://dx.doi.org/10.1038/nm.1854.

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46

Kuriki, Yugo, Mako Kamiya, Hidemasa Kubo, et al. "Establishment of Molecular Design Strategy To Obtain Activatable Fluorescent Probes for Carboxypeptidases." Journal of the American Chemical Society 140, no. 5 (2018): 1767–73. http://dx.doi.org/10.1021/jacs.7b11014.

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47

Huang, Jiaguo, and Kanyi Pu. "Activatable Molecular Probes for Second Near‐Infrared Fluorescence, Chemiluminescence, and Photoacoustic Imaging." Angewandte Chemie International Edition 59, no. 29 (2020): 11717–31. http://dx.doi.org/10.1002/anie.202001783.

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48

Achilefu, Samuel. "Rapid response activatable molecular probes for intraoperative optical image-guided tumor resection." Hepatology 56, no. 3 (2012): 1170–73. http://dx.doi.org/10.1002/hep.25807.

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49

Huang, Jiaguo, and Kanyi Pu. "Activatable Molecular Probes for Second Near‐Infrared Fluorescence, Chemiluminescence, and Photoacoustic Imaging." Angewandte Chemie 132, no. 29 (2020): 11813–27. http://dx.doi.org/10.1002/ange.202001783.

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50

Yang, Yanling, and Fan Zhang. "Cover Feature: Activatable Chemiluminescent Molecular Probes for Bioimaging and Biosensing (2/2021)." Analysis & Sensing 1, no. 2 (2021): 71. http://dx.doi.org/10.1002/anse.202100010.

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