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Journal articles on the topic 'Active NDA'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Rodriguez, Douglas Chase, Kamel Abbas, Jean-Michel Crochemore, et al. "Utilizing nuclear data in delayed gamma-ray spectroscopy inverse Monte Carlo analysis." EPJ Web of Conferences 239 (2020): 17005. http://dx.doi.org/10.1051/epjconf/202023917005.

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Safeguards verification of uranium and plutonium in high-radioactivity nuclear material is currently performed using destructive analysis techniques. However, the preparation method is a burden on both the safeguards inspectors and facility operators. While nondestructive assay (NDA) techniques would improve the efficiency and time, there are no passive NDA techniques available to directly verify the U and Pu content. As an alternative, the JAEA and JRC are collaboratively developing the Delayed Gamma-ray Spectroscopy (DGS) active-interrogation NDA technique to evaluate the fissile composition

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2

Gauvin, David V., Zachary J. Zimmermann, and Mary Jeanne Kallman. "Nonclinical abuse liability testing of new CNS-active drugs: Role of sex as a critical factor for drug scheduling." Drug Science, Policy and Law 7 (January 2021): 205032452097448. http://dx.doi.org/10.1177/2050324520974486.

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All new drugs targeting or influencing the central nervous system (CNS) must be screened for Drug Abuse Liability (DAL) prior to license approval by the FDA. Drug discrimination, self-administration, and drug dependence potential study designs are three core behavioral assays proposed in the 2017 FDA Guidance to Industry on Abuse Liability Testing for submission to the agencies for review at the time of the NDA submission. There are no international or federal drug control agency requirements for which animal species to use and selection of the test parameters for the sex, strain, age, dose ra

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3

Simon, Gerold, and Marina Sokcic-Kostic. "Famos III, burn-up measurement system suitable for la Hague acceptance criteria control." Nuclear Technology and Radiation Protection 17, no. 1-2 (2002): 68–70. http://dx.doi.org/10.2298/ntrp0202068s.

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Fuel Assembly Monitoring System (FAMOS) was developed to set up a NDA method for the characterization of light water reactor fuel assemblies. The applied active/passive monitoring system made total characterization of fuel assemblies possible, without any previous knowledge of fuel assembly data or reactor operating data. FAMOS III measurement system was especially developed for the determination of fuel assembly burn-up which is suitable for the control of the acceptance criteria in the so-called La Hague measurements.

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Zhang, P. J., C. B. Wang, and L. Ye. "A type III radio burst automatic analysis system and statistic results for a half solar cycle with Nançay Decameter Array data." Astronomy & Astrophysics 618 (October 2018): A165. http://dx.doi.org/10.1051/0004-6361/201833260.

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Aims. We design an event recognition-analysis system that can automatically detect solar type III radio burst and can mine information of the burst from the dynamic spectra observed by Nançay Decameter Array (NDA). We investigate the frequency drift rate of type III bursts and the speed of electron beams responsible for the generation of the bursts. Methods. Several computer vision methods are used in this automatic analysis system. The Hough transform is performed to recognize the line segment associated with type III bursts in the dynamic spectra. A modified active contour model is used to t

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Dhulia, Iva, Himani Patel, Narendra Chauhan, and Nidhi Pardeshi. "FDA's drug regulatory pathways, its development strategies and regulatory considerations." International Journal of Drug Regulatory Affairs 9, no. 2 (2021): 6–15. http://dx.doi.org/10.22270/ijdra.v9i2.460.

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People who are interested in drug development may be aware that New Drug Applications (NDA) and Abbreviated New Drug Applications (ANDA) are 2 of the FDA's regulatory pathways for how prescription drugs can be approved and ultimately reach the market. In basic terms, NDAs are for new drugs that have not yet been approved and ANDAs are for generic products. NDA, also called 505 (b)(1), is the format that manufacturers use to bring a formal proposal to the FDA that a new drug should be approved and made available for use by patients in the United States. Under 505(b)(1), all investigations

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6

Cong, Lanmei, Xiaocong Li, and Ancai Zhang. "Multiobject Holographic Feedback Control of Differential Algebraic System with Application to Power System." Mathematical Problems in Engineering 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/415281.

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A multiobject holographic feedback (MOHF) control method for studying the nonlinear differential algebraic (NDA) system is proposed. In this method, the nonlinear control law is designed in a homeomorphous linear space by means of constructing the multiobject equations (MOEq) which is in accord with Brunovsky normal form. The objective functions of MOEq are considered to be the errors between the output functions and their references. The relative degree for algebraic system is defined that is key to connecting the nonlinear and the linear control laws. Pole assignment method is addressed for

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7

Patel, Jimi, Priti Mehta, and Vaishali Kothari. "COMPARISON OF GLOBAL REGULATORY GUIDELINES FOR AVAILABILITY OF DIFFERENT BIOWAIVER PROVISIONS AND APPLICATION REQUIREMENTS OF BIOPHARMACEUTICS CLASSIFICATION SYSTEM (BCS) BASED BIOWAIVER." International Journal of Drug Regulatory Affairs 3, no. 3 (2018): 8–20. http://dx.doi.org/10.22270/ijdra.v3i3.167.

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To waive a complete and systemic Bioequivalence (BE) study, Biowaiver or Request for a Biowaiver is a fast track approach to boost the drug development process. Over the past three-four years the Biowaiver market shows greater number of Biowaiver submissions and the wider use of In-vitro permeability study. Biowaiver is a beneficial approach for getting approval of Abbreviated New Drug Application (ANDA) while, BCS based Biowaiver is the novel approach to gain approval for New Drug Application (NDA) as well as ANDA. A Biopharmaceutics Classification System (BCS) based Biowaiver is an exemption

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8

Flamm, Robert K., Dee Shortridge, Michael D. Huband, Sandra McCurdy, and Michael A. Pfaller. "Activity of Delafloxacin When Tested Against Bacterial Surveillance Isolates Collected in the US and Europe During 2014–2016 as Part of a Global Surveillance Program." Open Forum Infectious Diseases 4, suppl_1 (2017): S373—S374. http://dx.doi.org/10.1093/ofid/ofx163.918.

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Abstract Background Delafloxacin (DLX) is an investigational anionic fluoroquinolone with an NDA that is under US FDA review to treat acute bacterial skin and skin structure infections and is undergoing Phase 3 studies to treat community-acquired bacterial pneumonia. Methods A total of 36,683 Gram-positive (GP) and -negative (GN) bacteria isolated during 2014–2016 were selected from medical centers in the US and Europe. Susceptibility testing (S) was performed by frozen-form broth microdilution methods for DLX and comparators. Results DLX was very active against Staphylococcus aureus (SA, n =

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9

Micke, Warren C., Joseph A. Grant, Maxwell V. Norton, and James T. Yeager. "CHEMICAL THINNING OF `GRANNY SMITH' APPLE." HortScience 25, no. 9 (1990): 1121G—1121. http://dx.doi.org/10.21273/hortsci.25.9.1121.

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Under California conditions `Granny Smith' apple does not “self-thin” sufficiently to promote good return bloom nor to provide fruit size desired for the fresh market. Preliminary studies conducted during 1985-87 indicated that 1-naphthyl N-methylcarbamate (carbaryl), 1-naphthaleneacetic Acid (NAA), and 1-naphthaleneacetamide (NAD) could be useful for thinning `Granny Smith'. Detailed studies conducted in 1988 and 89 using dilute handgun applications demonstrated that all 3 materials provided reasonable thinning as shown by fruit set counts. NAA and NAD tended to slow fruit growth as compared

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Micke, Warren C., Joseph A. Grant, Maxwell V. Norton, and James T. Yeager. "CHEMICAL THINNING OF `GRANNY SMITH' APPLE." HortScience 25, no. 9 (1990): 1121g—1121. http://dx.doi.org/10.21273/hortsci.25.9.1121g.

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Under California conditions `Granny Smith' apple does not “self-thin” sufficiently to promote good return bloom nor to provide fruit size desired for the fresh market. Preliminary studies conducted during 1985-87 indicated that 1-naphthyl N-methylcarbamate (carbaryl), 1-naphthaleneacetic Acid (NAA), and 1-naphthaleneacetamide (NAD) could be useful for thinning `Granny Smith'. Detailed studies conducted in 1988 and 89 using dilute handgun applications demonstrated that all 3 materials provided reasonable thinning as shown by fruit set counts. NAA and NAD tended to slow fruit growth as compared

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11

Zitzer, Sabine, and Thomas Schleid. "Ein neues Selten-Erd-Metall(III)-Oxidchlorid-Oxotellurat(IV): Nd5O4Cl3[TeO3]2 / A New Rare Earth-Metal(III) Oxide Chloride Oxotellurate(IV): Nd5O4Cl3[TeO3]2." Zeitschrift für Naturforschung B 64, no. 2 (2009): 197–203. http://dx.doi.org/10.1515/znb-2009-0209.

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Pale violet, plate-like single crystals of the title compound, neodymium(III) oxide chloride oxotellurate( IV) Nd5O4Cl3[TeO3]2, can be obtained by the reaction of Nd2O3 with NdCl3 and TeO2 in equimolar ratios in evacuated silica ampoules within five days at 775 °C with an excess of CsCl added as fluxing agent. Nd5O4Cl3[TeO3]2 crystallizes in the monoclinic space group C2/m (no. 12) with the lattice parameters a = 1270.61(9), b = 562.70(4), c = 1008.97(8) pm, β = 90.784(3)°and Z = 2, and is thus isostructural to the lanthanoid(III) oxide halide oxoselenates(IV) Tb5O4Cl3[SeO3]2 and Gd5O4Br3[SeO3

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12

Röpke, Michael, Daniel Riepl, Patricia Saura, et al. "Deactivation blocks proton pathways in the mitochondrial complex I." Proceedings of the National Academy of Sciences 118, no. 29 (2021): e2019498118. http://dx.doi.org/10.1073/pnas.2019498118.

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Cellular respiration is powered by membrane-bound redox enzymes that convert chemical energy into an electrochemical proton gradient and drive the energy metabolism. By combining large-scale classical and quantum mechanical simulations with cryo-electron microscopy data, we resolve here molecular details of conformational changes linked to proton pumping in the mammalian complex I. Our data suggest that complex I deactivation blocks water-mediated proton transfer between a membrane-bound quinone site and proton-pumping modules, decoupling the energy-transduction machinery. We identify a putati

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13

Pang, Eric, William Chong, and Markham C. Luke. "Scientific and Regulatory Considerations for the Approval of the First Generic Glucagon." Journal of the Endocrine Society 5, Supplement_1 (2021): A324—A325. http://dx.doi.org/10.1210/jendso/bvab048.662.

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Abstract Glucagon for Injection (NDA 020928) is a polypeptide hormone identical to human glucagon approved 20 years ago for severe hypoglycemia in patients with diabetes mellitus. On Dec 28, 2020, the U.S. FDA approved the first generic version of glucagon for injection USP, 1 mg/vial packaged in an emergency kit. The generic and the reference listed drug (RLD) version, i.e., the innovator version, of glucagon were each produced through different manufacturing processes. The RLD version of glucagon is produced via recombinant DNA in yeast while the generic version of glucagon is produced by pe

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14

Tocho, J. O., F. Jaque, J. García Solé, E. Camarillo, F. Cussó, and J. E. Muñoz Santiuste. "Nd3+active sites in Nd:MgO:LiNbO3lasers." Applied Physics Letters 60, no. 26 (1992): 3206–8. http://dx.doi.org/10.1063/1.106740.

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15

Scribbans, Trisha D., Brittany A. Edgett, Jacob T. Bonafiglia, Brittany L. Baechler, Joe Quadrilatero, and Brendon J. Gurd. "A systematic upregulation of nuclear and mitochondrial genes is not present in the initial postexercise recovery period in human skeletal muscle." Applied Physiology, Nutrition, and Metabolism 42, no. 6 (2017): 571–78. http://dx.doi.org/10.1139/apnm-2016-0455.

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The purpose of the current investigation was to determine if an exercise-mediated upregulation of nuclear and mitochondrial-encoded genes targeted by the transcriptional co-activator peroxisome-proliferator-activated receptor gamma co-activator-1 alpha (PGC-1α) occurs in a systematic manner following different exercise intensities in humans. Ten recreationally active males (age: 23 ± 3 years; peak oxygen uptake: 41.8 ± 6.6 mL·kg−1·min−1) completed 2 acute bouts of work-matched interval exercise at ∼73% (low; LO) and ∼100% (high; HI) of work rate at peak oxygen uptake in a randomized crossover

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16

Babot, Marion, Paola Labarbuta, Amanda Birch, et al. "ND3, ND1 and 39kDa subunits are more exposed in the de-active form of bovine mitochondrial complex I." Biochimica et Biophysica Acta (BBA) - Bioenergetics 1837, no. 6 (2014): 929–39. http://dx.doi.org/10.1016/j.bbabio.2014.02.013.

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17

ASANUMA, H., O. HAGA, and M. IMORI. "SMS-05: Development of High Performance CFRP/Metal Active Laminates(SMS-I: SMART MATERIALS AND STRUCTURES, NDE)." Proceedings of the JSME Materials and Processing Conference (M&P) 2005 (2005): 25. http://dx.doi.org/10.1299/jsmeintmp.2005.25_2.

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18

Park, Kyung Soo, Min Hye Jeong, and Jong Wook Bae. "Synergy Effects of Cobalt Oxides on Ni/Co-Embedded Al2O3 for Hydrogen-Rich Syngas Production by Steam Reforming of Propane." Catalysts 10, no. 4 (2020): 461. http://dx.doi.org/10.3390/catal10040461.

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The synergetic effects of Co oxides on the Ni/CoAl (NCA) catalysts were observed at an optimal molar ratio of Al/Co = 2 (NCA(2)) due to the partial formations of thermally stable spinel CoAl2O4 phases for the steam reforming of propane (SRP). The optimal content of the spinel CoAl2O4 phases on the NCA(2) was responsible for the formation of the relatively active oxophilic metallic Co nanoparticles with a smaller amount of less active NiAl2O4 on the surfaces by preserving the relative amount of metallic Co of 68% and 52% in the reduced and used catalysts, which enhanced the catalytic activity a

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19

Azevedo, J. L., and B. C. Hyman. "Molecular characterization of lengthy mitochondrial DNA duplications from the parasitic nematode Romanomermis culicivorax." Genetics 133, no. 4 (1993): 933–42. http://dx.doi.org/10.1093/genetics/133.4.933.

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Abstract Complete nucleotide sequences, precise endpoints and coding potential of several 3.0-kilobase mitochondrial DNA (mtDNA) repeating units derived from two isofemale lineages of the mermithid nematode Romanomermis culicivorax have been determined. Endpoint analysis has allowed us to infer deletion and inversion events that most likely generated the present day repeat configuration. Each amplified unit contains the genes for NADH dehydrogenase subunits 3 and 6 (ND3 and ND6), an open reading frame (ORF 1) that represents a cytochrome P450-like gene, and three additional unidentified open r

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Oleaga, A., R. Balda, J. Fernández, M. D. Serrano, and E. Dieguez. "Nd3+active sites in Bi12SiO20:Nd: V codoped crystals." Journal of Luminescence 71, no. 4 (1997): 305–12. http://dx.doi.org/10.1016/s0022-2313(97)00095-1.

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21

Cysique, Lucette A., Lauriane Jugé, Thomas Gates, et al. "Covertly active and progressing neurochemical abnormalities in suppressed HIV infection." Neurology - Neuroimmunology Neuroinflammation 5, no. 1 (2018): e430. http://dx.doi.org/10.1212/nxi.0000000000000430.

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ObjectiveTo assess whether HIV-related brain injury is progressive in persons with suppressed HIV infection.MethodsSeventy-three HIV+ virally suppressed men and 35 HIV− men, screened for psychiatric and alcohol/drug use disorders, underwent neuropsychological evaluation and proton magnetic resonance spectroscopy (1H-MRS) at baseline and after and 23 ± 5 months. 1H-MRS included brain regions known to be vulnerable to HIV and aging: frontal white matter (FWM), posterior cingulate cortex (PCC), and caudate area (CA). Major brain metabolites such as creatine (Cr: marker of cellular energy), N-acet

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Kitson, T. M., and K. E. Kitson. "Probing the active site of cytoplasmic aldehyde dehydrogenase with a chromophoric reporter group." Biochemical Journal 300, no. 1 (1994): 25–30. http://dx.doi.org/10.1042/bj3000025.

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3,4-Dihydro-3-methyl-6-nitro-2H-1,3-benzoxazin-2-one (‘DMNB’) reacts with cytoplasmic aldehyde dehydrogenase in a similar way to that previously observed with the structurally related p-nitrophenyl dimethylcarbamate, but provides a covalently linked p-nitrophenol-containing reporter group at the enzyme's active site. The pKa of the enzyme-linked reporter group is much higher than that of free p-nitrophenol, which is consistent with its being in a very hydrophobic environment, or possibly one containing negative charge. Upon binding of NAD+ to the modified enzyme, the pKa falls dramatically, by

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Albrecht, G., M. Gruneisen, and D. Smith. "An active mode-locked Q-switched oscillator using Nd3+doped glass as the active medium." IEEE Journal of Quantum Electronics 21, no. 8 (1985): 1189–94. http://dx.doi.org/10.1109/jqe.1985.1072789.

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Ding, M. Y., J. J. Hou, Y. J. Yuan, et al. "Nd3+/Yb3+ cascade-sensitized single-band red upconversion emission in active-core/active-shell nanocrystals." Nanotechnology 29, no. 34 (2018): 345704. http://dx.doi.org/10.1088/1361-6528/aaca76.

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Nishikawa, Kiisa. "Titin: A Tunable Spring in Active Muscle." Physiology 35, no. 3 (2020): 209–17. http://dx.doi.org/10.1152/physiol.00036.2019.

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Muscle has conventionally been viewed as a motor that converts chemical to kinetic energy in series with a passive spring, but new insights emerge when muscle is viewed as a composite material whose elastic elements are tuned by activation. New evidence demonstrates that calcium-dependent binding of N2A titin to actin increases titin stiffness in active skeletal muscles, which explains many long-standing enigmas of muscle physiology.

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LaRonde-LeBlanc, Nicole, Melissa Resto, and Barbara Gerratana. "Regulation of active site coupling in glutamine-dependent NAD+ synthetase." Nature Structural & Molecular Biology 16, no. 4 (2009): 421–29. http://dx.doi.org/10.1038/nsmb.1567.

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27

Shrestha, Umesh Krishna, and Bijaya Pant. "Production of bergenin, an active chemical constituent in the callus of Bergenia ciliata (Haw.) Sternb." Botanica Orientalis: Journal of Plant Science 8 (March 2, 2012): 40–44. http://dx.doi.org/10.3126/botor.v8i0.5557.

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In vitro culture of Bergenia ciliata (Haw.) Sternb. was carried out for the examination of bergenin content. Leaf explants were cultured in MS (Murashige and Skoog) basal media supplemented with or without phytohormones. The hormonal series maintained were in the range of 0-2 mg l-1 for BAP (6-benzyl amino purine) and 0-1.5 mg l-1 for NAA (α-naphthalene acetic acid). Bergenin content of in vitro grown tissues of B. ciliata was compared with that of wild plants collected from three different localities of Nepal. The best growth of callus and plantlets occurred in the media containing BAP 1.0 mg

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Díaz-Sánchez, Ángel G., Lilian González-Segura, Enrique Rudiño-Piñera, Alfonso Lira-Rocha, Alfredo Torres-Larios, and Rosario A. Muñoz-Clares. "Novel NADPH–cysteine covalent adduct found in the active site of an aldehyde dehydrogenase." Biochemical Journal 439, no. 3 (2011): 443–55. http://dx.doi.org/10.1042/bj20110376.

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PaBADH (Pseudomonas aeruginosa betaine aldehyde dehydrogenase) catalyses the irreversible NAD(P)+-dependent oxidation of betaine aldehyde to its corresponding acid, the osmoprotector glycine betaine. This reaction is involved in the catabolism of choline and in the response of this important pathogen to the osmotic and oxidative stresses prevalent in infection sites. The crystal structure of PaBADH in complex with NADPH showed a novel covalent adduct between the C2N of the pyridine ring and the sulfur atom of the catalytic cysteine residue, Cys286. This kind of adduct has not been reported pre

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Pfoh, Roland, Emil F. Pai, and Vivian Saridakis. "Nicotinamide mononucleotide adenylyltransferase displays alternate binding modes for nicotinamide nucleotides." Acta Crystallographica Section D Biological Crystallography 71, no. 10 (2015): 2032–39. http://dx.doi.org/10.1107/s1399004715015497.

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Nicotinamide mononucleotide adenylyltransferase (NMNAT) catalyzes the biosynthesis of NAD+and NaAD+. The crystal structure of NMNAT fromMethanobacterium thermoautotrophicumcomplexed with NAD+and SO42−revealed the active-site residues involved in binding and catalysis. Site-directed mutagenesis was used to further characterize the roles played by several of these residues. Arg11 and Arg136 were implicated in binding the phosphate groups of the ATP substrate. Both of these residues were mutated to lysine individually. Arg47 does not interact with either NMN or ATP substrates directly, but was de

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Fleischmann, E. H. "Active immunization against hepatitis A in dialysis patients." Nephrology Dialysis Transplantation 17, no. 10 (2002): 1825–28. http://dx.doi.org/10.1093/ndt/17.10.1825.

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Lautier, Dominique, Danièle Poirier, Annie Boudreau, Moulay A. Alaoui Jamali, André Castonguay, and Guy Poirier. "Stimulation of poly(ADP-ribose) synthesis by free radicals in C3H10T1/2 cells: relationship with NAD metabolism and DNA breakage." Biochemistry and Cell Biology 68, no. 3 (1990): 602–8. http://dx.doi.org/10.1139/o90-085.

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We have studied the effect of H2O2 and O2− produced by xanthine and xanthine oxidase on NAD catabolism, poly(ADP-ribose) synthesis, and production of DNA single-strand breaks in C3H10T1/2 cells. The results show a correlation between the induction of DNA single-strand breaks, the decrease of NAD pool, and the accumulation of polymer. New techniques, based on affinity chromatography and reversed-phase high pressure liquid chromatography, have allowed an accurate determination of polymer contents and showed a 20-fold stimulation of polymer biosynthesis induced by active oxygen species. Inhibitio

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Amaye, Isis, Thomas Heinbockel, Julia Woods, Zejun Wang, Miguel Martin-Caraballo, and Patrice Jackson-Ayotunde. "6 Hz Active Anticonvulsant Fluorinated N-Benzamide Enaminones and Their Inhibitory Neuronal Activity." International Journal of Environmental Research and Public Health 15, no. 8 (2018): 1784. http://dx.doi.org/10.3390/ijerph15081784.

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A small library of novel fluorinated N-benzamide enaminones were synthesized and evaluated in a battery of acute preclinical seizure models. Three compounds (GSA 62, TTA 35, and WWB 67) were found to have good anticonvulsant activity in the 6-Hz ‘psychomotor’ 44-mA rodent model. The focus of this study was to elucidate the active analogs’ mode of action on seizure-related molecular targets. Electrophysiology studies were employed to evaluate the compounds’ ability to inhibit neuronal activity in central olfactory neurons, mitral cells, and sensory-like ND7/23 cells, which express an assortment

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Prorok, Katarzyna, Mirosława Pawlyta, Wiesław Stręk, and Artur Bednarkiewicz. "Energy Migration Up-conversion of Tb3+ in Yb3+ and Nd3+ Codoped Active-Core/Active-Shell Colloidal Nanoparticles." Chemistry of Materials 28, no. 7 (2016): 2295–300. http://dx.doi.org/10.1021/acs.chemmater.6b00353.

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Perez-Sanchez, C., L. M. Sánchez-Mendoza, M. D. C. Abalos-Aguilera, et al. "POS0394 NAD+ BOOSTERS REESTABLISH THE ALTERED NAD+ METABOLISM OF LEUKOCYTES FROM RHEUMATOID ARTHRITIS PATIENTS IMPROVING THEIR OXIDATIVE, APOPTOTIC AND INFLAMMATORY STATUS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 426.2–426. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2580.

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Background:NAD+ is an important cofactor and second messenger for multiple cellular processes that exhibits antioxidant, anti-apoptotic and anti-inflammatory properties. Pre-clinical studies in animal models of Rheumatoid Arthritis (RA) have demonstrated the therapeutic potential of NAD+ boosters in the control of the disease activity. However, to date no studies have been set up to evaluate the NAD+ metabolism and the therapeutic effects of NAD+ boosters in RA patients.Objectives:1- To study the NAD+ metabolism in RA patients and its association with key clinical features. 2- To evaluate the

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Fernández, J., A. Oleaga, R. Balda, M. D. Serrano, E. Dieguez, and M. A. Arriandiaga. "Nd3+ and Eu3+ active sites in Bi12SiO20 and Bi12SiO20: V5+ crystals." Optical Materials 8, no. 1-2 (1997): 91–97. http://dx.doi.org/10.1016/s0925-3467(97)00030-x.

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Kaminskii, A. A., H. J. Eichler, J. Garcia-Sole, et al. "Piezoelectric Sillenite Bi12SiO20:Nd3+. A New Laser and SRS-Active Crystal." physica status solidi (b) 210, no. 2 (1998): R9—R10. http://dx.doi.org/10.1002/(sici)1521-3951(199812)210:23.0.co;2-6.

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Korasick, David A., Tommi A. White, Srinivas Chakravarthy, and John J. Tanner. "NAD + promotes assembly of the active tetramer of aldehyde dehydrogenase 7A1." FEBS Letters 592, no. 19 (2018): 3229–38. http://dx.doi.org/10.1002/1873-3468.13238.

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Voronko, Yu K., S. B. Gessen, N. A. Es'kov, A. A. Sobol, S. N. Ushakov, and L. I. Tsymbal. "Efficient active media based on Nd3+-activated calcium niobium gallium garnets." Soviet Journal of Quantum Electronics 20, no. 3 (1990): 246–49. http://dx.doi.org/10.1070/qe1990v020n03abeh005597.

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Xia, Meng, Dacheng Zhou, Yong Yang, Zhengwen Yang, and Jianbei Qiu. "Synthesis of Ultrasmall Hexagonal NaGdF4: Yb3+Er3+@ NaGdF4: Yb3+@ NaGdF4: Nd3+Active-Core/Active-Shell/Active-Shell Nanoparticles with Enhanced Upconversion Luminescence." ECS Journal of Solid State Science and Technology 6, no. 4 (2017): R41—R46. http://dx.doi.org/10.1149/2.0031704jss.

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Dudina, Margarita A., Sergey A. Dogadin, and Аndrey A. Savchenko. "The negative effect of GH/IGF-1 excess on NAD- and NADP-dependent blood lymphocytes dehydrogenases activity in acromegaly." Problems of Endocrinology 62, no. 5 (2016): 59–60. http://dx.doi.org/10.14341/probl201662559-60.

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Background. Acromegaly is a rare serious condition characterized by chronic hypersecretion of growth hormone (GH) from a pituitary adenoma and induces the synthesis of insulin-like growth factor I (IGF-1). The idea of the crucial GH importance not only in the control of cell proliferation and differentiation, but, also, in the regulation of immune cells metabolism allows to think that chronic excess GH/IGF-I in acromegaly is the potent effector distortion of the immune response mechanisms. Aim. To study the NAD(P)-dependent dehydrogenases level in blood lymphocytes and their interaction with G

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Chuenchor, Watchalee, Tzanko I. Doukov, Melissa Resto, Andrew Chang, and Barbara Gerratana. "Regulation of the intersubunit ammonia tunnel in Mycobacterium tuberculosis glutamine-dependent NAD+ synthetase." Biochemical Journal 443, no. 2 (2012): 417–26. http://dx.doi.org/10.1042/bj20112210.

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Glutamine-dependent NAD+ synthetase is an essential enzyme and a validated drug target in Mycobacterium tuberculosis (mtuNadE). It catalyses the ATP-dependent formation of NAD+ from NaAD+ (nicotinic acid–adenine dinucleotide) at the synthetase active site and glutamine hydrolysis at the glutaminase active site. An ammonia tunnel 40 Å (1 Å=0.1 nm) long allows transfer of ammonia from one active site to the other. The enzyme displays stringent kinetic synergism; however, its regulatory mechanism is unclear. In the present paper, we report the structures of the inactive glutaminase C176A variant

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Behairy, Maha AbdelmoneimMoneim, Marwa Mosad Shakweer, and Tamer El Said. "SP056VALUE OF IMMUNOHISTOCHEMICAL EXPRESSION OF PODOCALYXIN IN ACTIVE LUPUS NEPHRITIS." Nephrology Dialysis Transplantation 31, suppl_1 (2016): i104—i105. http://dx.doi.org/10.1093/ndt/gfw157.17.

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Krivoruchko, Natalya, Lina Zaripova, Saltanat Tuganbekova, and Gulnar Rakhimbekova. "FP122AUTOLOGOUS STEM CELLS TRANSPLANTATION IN PATIENTS WITH ACTIVE LUPUS NEPHRITIS." Nephrology Dialysis Transplantation 30, suppl_3 (2015): iii107—iii108. http://dx.doi.org/10.1093/ndt/gfv171.11.

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Hirschberg, R. "Biologically active peptides in acute renal failure: recent clinical trials." Nephrology Dialysis Transplantation 12, no. 8 (1997): 1563–66. http://dx.doi.org/10.1093/ndt/12.8.1563.

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Galloway, T. S., R. M. Tait, and S. van Heyningen. "Photolabelling of cholera toxin by NAD+." Biochemical Journal 242, no. 3 (1987): 927–30. http://dx.doi.org/10.1042/bj2420927.

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When cholera toxin is incubated under u.v. light with NAD+ labelled in either the adenine or the nicotinamide moiety, radioactivity becomes covalently bound to the protein. The reaction is specific for cholera toxin, and is inhibited by excess unlabelled NAD+ or NAD analogues. Only the active A 1 chain of the toxin is labelled. The u.v.-absorption spectrum of the product is very similar to that of NAD+, and shows the same reaction with cyanide. The nature of the product is therefore different from that found when diphtheria toxin is photolabelled [Carroll & Collier (1984) Proc. Natl. Acad.

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LABROU, Nikolaos E., and Daniel J. RIGDEN. "Active-site characterization of Candida boidinii formate dehydrogenase." Biochemical Journal 354, no. 2 (2001): 455–63. http://dx.doi.org/10.1042/bj3540455.

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NAD+-dependent formate dehydrogenase (FDH) from Candida boidinii was cloned and expressed to a high level in Escherichia coli (20% of soluble E. coli protein). Molecular modelling studies were used to create a three-dimensional model of C. boidinii FDH, based on a known structure of the Pseudomonas sp. 101 enzyme. This model was used for investigating the catalytic mechanism by site-directed mutagenesis. Eleven forms of C. boidinii FDH were characterized by steady-state kinetic analysis: the wild type as well as 10 mutants involving single (Phe-69–Ala, Asn-119–His, Ile-175–Ala, Gln-197–Leu, Ar

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Korolkov, V. P., R. K. Nasyrov, A. G. Poleshchuk, Yu D. Arapov, and A. F. Ivanov. "Conformal optical elements for correcting wavefront distortions in YAG : Nd3+ active elements." Quantum Electronics 43, no. 2 (2013): 117–21. http://dx.doi.org/10.1070/qe2013v043n02abeh015034.

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Liu, Chun-Xiao, Zhe-Yuan Luo, Yu-Wen Li, et al. "Active waveguides by low-fluence carbon implantation in Nd3+-doped fluorophosphate glasses." Modern Physics Letters B 30, no. 02 (2016): 1550266. http://dx.doi.org/10.1142/s0217984915502668.

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A planar waveguide in the Nd[Formula: see text]-doped fluorophosphate glass is fabricated by a 6.0 MeV C[Formula: see text] ion implantation at a low-fluence of [Formula: see text] ions/cm2. The fluence is close to that in semiconductor industry. The dark mode spectra are recorded by a model 2010 prism coupler. The energy losses during the implantation process and the refractive index profile of the waveguide are simulated by the SRIM 2010 code and the reflectivity calculation method (RCM), respectively. The near-field light intensity profile and the propagation loss of the waveguide are measu

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Devedjiev, Yancho, Jindrich Symersky, Raj Singh, et al. "Stabilization of active-site loops in NH3-dependent NAD+synthetase fromBacillus subtilis." Acta Crystallographica Section D Biological Crystallography 57, no. 6 (2001): 806–12. http://dx.doi.org/10.1107/s0907444901003523.

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Muller, H. M., and F. Schuber. "Asymmetric reassociation of calf spleen NAD+ glycohydrolase into liposomes." Biochemical Journal 246, no. 2 (1987): 319–24. http://dx.doi.org/10.1042/bj2460319.

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NAD+ glycohydrolase (NAD+ nucleosidase, EC 3.2.2.6) can be solubilized from calf spleen microsomes (microsomal fractions) by steapsin or by detergents to yield respectively a hydrophilic (i.e. water-soluble) and a hydrophobic form of the enzyme. The detergent-solubilized enzyme was successfully reassociated into phosphatidylcholine liposomes either by a cholate-dialysis or by a gel-filtration procedure. In both cases the incorporation of NAD+ glycohydrolase was found to be completely asymmetric, i.e. the active site of the enzyme was exposed only at the outer surface of the vesicles. By contra

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