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Journal articles on the topic 'Active speaker detection'

Author: Grafiati

Published: 7 September 2024

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1

Assunção, Gustavo, Nuno Gonçalves, and Paulo Menezes. "Bio-Inspired Modality Fusion for Active Speaker Detection." Applied Sciences 11, no. 8 (2021): 3397. http://dx.doi.org/10.3390/app11083397.

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Human beings have developed fantastic abilities to integrate information from various sensory sources exploring their inherent complementarity. Perceptual capabilities are therefore heightened, enabling, for instance, the well-known "cocktail party" and McGurk effects, i.e., speech disambiguation from a panoply of sound signals. This fusion ability is also key in refining the perception of sound source location, as in distinguishing whose voice is being heard in a group conversation. Furthermore, neuroscience has successfully identified the superior colliculus region in the brain as the one re

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Pu, Jie, Yannis Panagakis, and Maja Pantic. "Active Speaker Detection and Localization in Videos Using Low-Rank and Kernelized Sparsity." IEEE Signal Processing Letters 27 (2020): 865–69. http://dx.doi.org/10.1109/lsp.2020.2996412.

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Lindstrom, Fredric, Keni Ren, Kerstin Persson Waye, and Haibo Li. "A comparison of two active‐speaker‐detection methods suitable for usage in noise dosimeter measurements." Journal of the Acoustical Society of America 123, no. 5 (2008): 3527. http://dx.doi.org/10.1121/1.2934471.

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Zhu, Ying-Xin, and Hao-Ran Jin. "Speaker Localization Based on Audio-Visual Bimodal Fusion." Journal of Advanced Computational Intelligence and Intelligent Informatics 25, no. 3 (2021): 375–82. http://dx.doi.org/10.20965/jaciii.2021.p0375.

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The demand for fluency in human–computer interaction is on an increase globally; thus, the active localization of the speaker by the machine has become a problem worth exploring. Considering that the stability and accuracy of the single-mode localization method are low, while the multi-mode localization method can utilize the redundancy of information to improve accuracy and anti-interference, a speaker localization method based on voice and image multimodal fusion is proposed. First, the voice localization method based on time differences of arrival (TDOA) in a microphone array and the face d

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Stefanov, Kalin, Jonas Beskow, and Giampiero Salvi. "Self-Supervised Vision-Based Detection of the Active Speaker as Support for Socially Aware Language Acquisition." IEEE Transactions on Cognitive and Developmental Systems 12, no. 2 (2020): 250–59. http://dx.doi.org/10.1109/tcds.2019.2927941.

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DAI, Hai, Kean CHEN, Yang WANG, and Haoxin YU. "Fault detection method of secondary sound source in ANC system based on impedance characteristics." Xibei Gongye Daxue Xuebao/Journal of Northwestern Polytechnical University 40, no. 6 (2022): 1242–49. http://dx.doi.org/10.1051/jnwpu/20224061242.

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As an indispensable component in an active noise control system, the working states of the secondary sound sources affect directly noise reduction and the robustness of the system. Therefore, it is very crucial to detect the working states of the secondary sound sources in the process of active control in real time. In this study, a real-time fault detection method for secondary sound sources during the process of active control is presented, and the corresponding detection algorithm is numerically given and experimentally verified. By collecting the input voltage and output current of the spe

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Ahmad, Zubair, Alquhayz, and Ditta. "Multimodal Speaker Diarization Using a Pre-Trained Audio-Visual Synchronization Model." Sensors 19, no. 23 (2019): 5163. http://dx.doi.org/10.3390/s19235163.

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Speaker diarization systems aim to find ‘who spoke when?’ in multi-speaker recordings. The dataset usually consists of meetings, TV/talk shows, telephone and multi-party interaction recordings. In this paper, we propose a novel multimodal speaker diarization technique, which finds the active speaker through audio-visual synchronization model for diarization. A pre-trained audio-visual synchronization model is used to find the synchronization between a visible person and the respective audio. For that purpose, short video segments comprised of face-only regions are acquired using a face detecti

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Wang, Shaolei, Zhongyuan Wang, Wanxiang Che, Sendong Zhao, and Ting Liu. "Combining Self-supervised Learning and Active Learning for Disfluency Detection." ACM Transactions on Asian and Low-Resource Language Information Processing 21, no. 3 (2022): 1–25. http://dx.doi.org/10.1145/3487290.

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Spoken language is fundamentally different from the written language in that it contains frequent disfluencies or parts of an utterance that are corrected by the speaker. Disfluency detection (removing these disfluencies) is desirable to clean the input for use in downstream NLP tasks. Most existing approaches to disfluency detection heavily rely on human-annotated data, which is scarce and expensive to obtain in practice. To tackle the training data bottleneck, in this work, we investigate methods for combining self-supervised learning and active learning for disfluency detection. First, we c

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Maltezou-Papastylianou, Constantina, Riccardo Russo, Denise Wallace, Chelsea Harmsworth, and Silke Paulmann. "Different stages of emotional prosody processing in healthy ageing–evidence from behavioural responses, ERPs, tDCS, and tRNS." PLOS ONE 17, no. 7 (2022): e0270934. http://dx.doi.org/10.1371/journal.pone.0270934.

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Past research suggests that the ability to recognise the emotional intent of a speaker decreases as a function of age. Yet, few studies have looked at the underlying cause for this effect in a systematic way. This paper builds on the view that emotional prosody perception is a multi-stage process and explores which step of the recognition processing line is impaired in healthy ageing using time-sensitive event-related brain potentials (ERPs). Results suggest that early processes linked to salience detection as reflected in the P200 component and initial build-up of emotional representation as

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Lahemer, Elfituri S. F., and Ahmad Rad. "An Audio-Based SLAM for Indoor Environments: A Robotic Mixed Reality Presentation." Sensors 24, no. 9 (2024): 2796. http://dx.doi.org/10.3390/s24092796.

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In this paper, we present a novel approach referred to as the audio-based virtual landmark-based HoloSLAM. This innovative method leverages a single sound source and microphone arrays to estimate the voice-printed speaker’s direction. The system allows an autonomous robot equipped with a single microphone array to navigate within indoor environments, interact with specific sound sources, and simultaneously determine its own location while mapping the environment. The proposed method does not require multiple audio sources in the environment nor sensor fusion to extract pertinent information an

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Gong, Yanbin, Qian Zhang, Bobby H. P. NG, and Wei Li. "BreathMentor." Proceedings of the ACM on Interactive, Mobile, Wearable and Ubiquitous Technologies 6, no. 2 (2022): 1–28. http://dx.doi.org/10.1145/3534595.

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Chronic Obstructive Pulmonary Disease (COPD) is currently the third major cause of death--more than three million people died from it in 2019. Given that COPD cannot be cured currently, immediate treatment is crucial. Pulmonary rehabilitation (PR) is widely used to prevent COPD deterioration. Patients are advised to undergo a PR at home to get sufficient treatment in time. Monitoring patients during home rehabilitation can help not only improve patient adherence but also collect data on patients' recovery progress from rehabilitation team's perspective. However, how to track if proper diaphrag

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Crotti, C., F. Bartoli, M. Manara, et al. "THU0421 TUMOR-INDUCED OSTEOMALACIA: DATA FROM A MONOCENTRIC EXPERIENCE ON 16 PATIENTS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 448.2–449. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4486.

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Background:Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome due to a phosphaturic tumor, which overproduces fibroblast growth factor-23 (FGF-23), causing hyperphosphaturia, hypophosphoremia, low 1,25(OH)2VitD3and osteomalacia. Locating the tumor is critical, because lesions are typically small, benign mesenchymal tumors, anywhere in the body; the delay between onset of symptoms and diagnosis ranges from 2.5–28 years. Surgical removal is the only effective therapeutic approach.Objectives:To retrospectively evaluate patients affected by TIO, investigating clinical management an

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Sunshine, Jacob. "Smart Speakers: The Next Frontier in mHealth." JMIR mHealth and uHealth 10, no. 2 (2022): e28686. http://dx.doi.org/10.2196/28686.

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The rapid dissemination and adoption of smart speakers has enabled substantial opportunities to improve human health. Just as the introduction of the mobile phone led to considerable health innovation, smart speaker computing systems carry several unique advantages that have the potential to catalyze new fields of health research, particularly in out-of-hospital environments. The recent rise and ubiquity of these smart computing systems holds significant potential for enhancing chronic disease management, enabling passive identification of unwitnessed medical emergencies, detecting subtle chan

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Michez, Adrien, Stéphane Broset, and Philippe Lejeune. "Ears in the Sky: Potential of Drones for the Bioacoustic Monitoring of Birds and Bats." Drones 5, no. 1 (2021): 9. http://dx.doi.org/10.3390/drones5010009.

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In the context of global biodiversity loss, wildlife population monitoring is a major challenge. Some innovative techniques such as the use of drones—also called unmanned aerial vehicle/system (UAV/UAS)—offer promising opportunities. The potential of UAS-based wildlife census using high-resolution imagery is now well established for terrestrial mammals or birds that can be seen on images. Nevertheless, the ability of UASs to detect non-conspicuous species, such as small birds below the forest canopy, remains an open question. This issue can be solved with bioacoustics for acoustically active s

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Gottfredsson, Magnus, Thorarinn Tyrfingsson, Valgerdur Runarsdottir, et al. "Treatment as Prevention for Hepatitis C (TraP HepC). A Real-world Experience from the First 12 Months of a Nationwide Elimination Program in Iceland." Open Forum Infectious Diseases 4, suppl_1 (2017): S42. http://dx.doi.org/10.1093/ofid/ofx162.101.

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Abstract Background Hepatitis C virus (HCV) infection is associated with significant morbidity and mortality. Iceland, an island with a population of 330,000 has a HCV seroprevalence of 0.3% and an estimated total of 800–1000 patients. There is good access to health care among people who inject drugs (PWID) and Iceland thus serves as an ideal setting for a proof of concept intervention, aiming for elimination of the disease as a public health threat. If elimination is to be achieved PWID, who are key drivers of transmission, need to be a focus of treatment scale up. Methods All patients in the

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Zheng, Hong-Ying, Gang Peng, Jian-Yong Chen, Caicai Zhang, James W. Minett, and William S.-Y. Wang. "The Influence of Tone Inventory on ERP without Focal Attention: A Cross-Language Study." Computational and Mathematical Methods in Medicine 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/961563.

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This study investigates the effect of tone inventories on brain activities underlying pitch without focal attention. We find that the electrophysiological responses to across-category stimuli are larger than those to within-category stimuli when the pitch contours are superimposed on nonspeech stimuli; however, there is no electrophysiological response difference associated with category status in speech stimuli. Moreover, this category effect in nonspeech stimuli is stronger for Cantonese speakers. Results of previous and present studies lead us to conclude that brain activities to the same n

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Numan, Yazan, Zaid Abdel Rahman, Justin Grenet, et al. "Gilteritinib Remains Clinically Active in Relapsed/Refractory FLT3 Mutated AML Previously Treated with FLT3 inhibitors." Blood 136, Supplement 1 (2020): 5–7. http://dx.doi.org/10.1182/blood-2020-137251.

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Background: Gilteritinib is approved for the treatment of relapsed/refractory (R/R) AML and FLT3-mutation (FLT3mut+). However, the gilteritinib phase 3 ADMIRAL study (Perl et al NEJM 2019) enrolled prior to widespread adoption of either midostaurin as a component of standard intensive induction and consolidation or post-transplant FLT3inhibitor (FLT3i) maintenance. Some mechanisms of drug resistance can be shared across FLT3i's, suggesting response to gilteritinib might differ in patients treated with frontline FLT3i. A better understanding of how prior therapy modulates response to gilteritin

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Volkova, Svitlana, and Eric Bell. "Identifying Effective Signals to Predict Deleted and Suspended Accounts on Twitter Across Languages." Proceedings of the International AAAI Conference on Web and Social Media 11, no. 1 (2017): 290–98. http://dx.doi.org/10.1609/icwsm.v11i1.14874.

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Social networks have an ephemerality to them where accounts and messages are constantly being edited, deleted, or marked as private. This continuous change comes from concerns around privacy, a potential desire for to be forgotten and suspicious behavior. In this study we present a novel task – predicting suspicious e.g., to be deleted or suspended accounts in social media. We analyze multiple datasets of thousands of active, deleted and suspended Twitter accounts to produce a series of predictive representations for the removal or shutdown of an account. We selected these accounts from speake

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Coyne, Joseph T., and Mark D. Lee. "The Effects of Visual Cues and Interstimulus Interval on Accuracy in Auditory Localization and Detection." Proceedings of the Human Factors and Ergonomics Society Annual Meeting 46, no. 17 (2002): 1613–17. http://dx.doi.org/10.1177/154193120204601718.

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Auditory localization is an increasingly important topic as the technology for audio displays is becoming more available. However, few studies examine the effects of multiple simultaneous distracters on auditory detection and localization performance. Previous research has found that detection and localization performance significantly drop as the number of distracters increases; however, it is not clear what causes these errors. In the present study, participants either had to localize an auditory stimulus or detect an auditory stimulus among multiple distracters. Similar to previous research

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Gish, Robert, and Vincent Streva. "1066. Immune Escape Mutant Detection Using Commercially Available Methods for Hepatitis B Surface Antigen Serological Testing." Open Forum Infectious Diseases 7, Supplement_1 (2020): S562. http://dx.doi.org/10.1093/ofid/ofaa439.1252.

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Abstract Background Although overall infection rates of Hepatitis B virus (HBV) in the United States (US) remain stable, as many as 2.2 million persons are still chronically infected with Hepatitis B Virus (HBV)1. Persons who inject drugs (PWID) are at a higher risk of HBV infection and since 2009 three states (KY, TN, WV) have reported up to a 114% increase in cases of acute HBV infection due to higher infection rates among a non-Hispanic white populations (30–39 years), and injection drug users2. Hepatitis B vaccination is recommended as primary prevention for adults who are at increased ris

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Maksymowych, W. P., S. Juhl Pedersen, U. Weber, et al. "FRI0302 WHAT IS THE IMPACT OF DISCREPANCY BETWEEN CENTRAL AND LOCAL READERS IN EVALUATION OF MRI SCANS ON THE CLASSIFICATION OF AXIAL SPONDYLOARTHRITIS? DATA FROM THE ASAS CLASSIFICATION COHORT STUDY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 740.2–741. http://dx.doi.org/10.1136/annrheumdis-2020-eular.6350.

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Background:Active MRI lesions typical of axial spondyloarthritis (axSpA) were reported in 61.6% and 2.2% of axSpA and not-axSpA patients, respectively, from the ASAS classification cohort (ASAS-CC)1. Discrepancy between local and central reader evaluation of MRI scans could result in differences in numbers of patients fulfilling the imaging arm of the ASAS classification criteria. But final classification may not be impacted if discrepant patients still fulfill the clinical arm.Objectives:We aimed to assess the impact of reader discrepancy in detection of active MRI lesions on the number of pa

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Bocchia, Monica, Lara Aprile, Santina Sirianni, et al. "Peripheral Blood Flow-Cytometry Chronic Myeloid Leukemia Stem Cells Detection and Quantification during Tyrosine Kinase Inhibitors Therapy." Blood 128, no. 22 (2016): 942. http://dx.doi.org/10.1182/blood.v128.22.942.942.

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Abstract Introduction: In chronic myeloid leukemia (CML), tyrosine Kinase Inhibitors (TKIs) treatment is a potentially life-time therapy for the majority of patients (pts), as few of them, only after achieving a deep and stable molecular response, may discontinue TKIs without recurrence of disease. Available data suggest that relapse after TKIs discontinuation is due to the persistence of leukemic stem cells (LSCs) intrinsically resistant to TKIs. Survival of CML LSCs may be the consequence of activation of several pathways BCR-ABL1 independent. qRT-PCR, the most sensitive assay to monitor dis

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Lambert, R., X. Baraliakos, S. Bernard, et al. "POS0989 DEVELOPMENT OF INTERNATIONAL CONSENSUS ON A STANDARDIZED IMAGE ACQUISITION PROTOCOL FOR DIAGNOSTIC EVALUATION OF THE SACROILIAC JOINTS BY MRI – AN ASAS-SPARTAN COLLABORATION." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 802.3–803. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3365.

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BackgroundIn 2009, ASAS published a ‘Definition of active sacroiliitis on MRI for classification of axial spondyloarthritis (axSpA)’. This definition relied on two MRI sequences to make this determination – semicoronal T1 and STIR. Since then, this approach has frequently been used for diagnosis, even though that was never the intent of the definition. In 2015, the European Society of Skeletal Radiology (ESSR) published its recommendations for an SIJ MRI image acquisition protocol (IAP) for diagnostic purposes that required 4 MRI sequences but there is still no IAP that has been widely accepte

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Deshpande, Pushkar, Christian Brandt, Stefan Debener, and Tobias Neher. "Comparing Clinically Applicable Behavioral and Electrophysiological Measures of Speech Detection, Discrimination, and Comprehension." Trends in Hearing 26 (January 2022): 233121652211397. http://dx.doi.org/10.1177/23312165221139733.

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Effective communication requires good speech perception abilities. Speech perception can be assessed with behavioral and electrophysiological methods. Relating these two types of measures to each other can provide a basis for new clinical tests. In audiological practice, speech detection and discrimination are routinely assessed, whereas comprehension-related aspects are ignored. The current study compared behavioral and electrophysiological measures of speech detection, discrimination, and comprehension. Thirty young normal-hearing native Danish speakers participated. All measurements were ca

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Blau, Olga, Franziska Behrenbeck, Mirgul Bayanova, Igor-Wolfgang Blau, and Lars Bullinger. "Characteristics of DNMT3A-R882 Mutation in AML." Blood 132, Supplement 1 (2018): 5263. http://dx.doi.org/10.1182/blood-2018-99-116652.

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Abstract Introduction Genetic mutations play an important role in the development and progression of acute myeloid leukemia (AML). One of the common aberration in AML is mutation in the epigenetic modifying gene, DNA methyltransferase 3α (DNMT3A). Despite the active investigations, the exact impact of mutation on the development of AML is not completely known. The occurrence of mutation in pre-leukemic cells explains a particular attention to DNMT3A. The most common mutation is located in codon R882 (DNMT3AR882mut). The objective of this study is to compare clinical and prognostic characterist

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Sung, Jee Eun, Sujin Choi, Bora Eom, Jae Keun Yoo, and Jee Hyang Jeong. "Syntactic Complexity as a Linguistic Marker to Differentiate Mild Cognitive Impairment From Normal Aging." Journal of Speech, Language, and Hearing Research 63, no. 5 (2020): 1416–29. http://dx.doi.org/10.1044/2020_jslhr-19-00335.

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Purpose In this study, we sought to identify critical linguistic markers that can differentiate sentence processing of individuals with mild cognitive impairment (MCI) from the sentence processing of normal-aging populations by manipulating sentences' linguistic complexity. We investigated whether passive sentences, as linguistically complex structures, can serve as linguistic markers that can contribute to diagnoses that distinguish MCI from normal aging. Method In total, 52 participants, including 26 adults with amnestic MCI and 26 cognitively unimpaired adults, participated in the study. Al

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Amichai, Eran, Gaddi Blumrosen, and Yossi Yovel. "Calling louder and longer: how bats use biosonar under severe acoustic interference from other bats." Proceedings of the Royal Society B: Biological Sciences 282, no. 1821 (2015): 20152064. http://dx.doi.org/10.1098/rspb.2015.2064.

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Active-sensing systems such as echolocation provide animals with distinct advantages in dark environments. For social animals, however, like many bat species, active sensing can present problems as well: when many individuals emit bio-sonar calls simultaneously, detecting and recognizing the faint echoes generated by one's own calls amid the general cacophony of the group becomes challenging. This problem is often termed ‘jamming’ and bats have been hypothesized to solve it by shifting the spectral content of their calls to decrease the overlap with the jamming signals. We tested bats’ respons

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Hay, Annette E., Sarit Assouline, Roland B. Walter, et al. "Accrual Barriers and Detection of Early Toxicity Signal in Older Less-Fit Patients Treated with Azacitidine and Nivolumab for Newly Diagnosed Acute Myeloid Leukemia (AML) or High-Risk Myelodysplastic Syndrome (MDS) in the SWOG 1612 Platform Randomized Phase II/III Clinical Trial." Blood 134, Supplement_1 (2019): 3905. http://dx.doi.org/10.1182/blood-2019-124320.

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Background: Less-fit patients with acute myeloid leukemia (AML) or high-risk myelodysplasia (MDS) age 60 years and older constitute the majority of patients with AML/MDS but are not well represented in clinical trials. DNA-methyltransferase inhibitor (HMA) monotherapy (e.g. azacitidine or decitabine) is usual. Overall response rates (ORR) are low; improvement in overall survival relative to supportive care alone is modest, highlighting the critical need for efficient identification of effective novel therapies. Blocking programed cell death protein-1 (PD-1) signaling with nivolumab may increas

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Vikse, J., Ø. Midtvedt, Ø. Molberg, et al. "OP0255 IGG4-RELATED DISEASE ACTIVITY ASSESSMENT INFLUENCED BY USE OF 18F-FDG PET/CT: DATA FROM A NORWEGIAN COHORT." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 169.1–169. http://dx.doi.org/10.1136/annrheumdis-2023-eular.3560.

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BackgroundThe IgG4-related disease (IgG4-RD) responder index (RI) is a validated tool to assess disease activity in IgG4-RD [1]. The RI reflects symptoms attributable to active IgG4-RD as well as relevant findings from the physical examination, imaging and laboratory evaluations, with higher scores reflecting more active disease. Multiorgan involvement and higher RI scores were identified as risk factors for relapse [2], indicating a need for more aggressive treatment. Whole-body18F-FDG PET/CT is a sensitive technique for detecting foci of active inflammation, but its use is limited by cost an

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Bansal, Radhika, Sagar Rakshit, Katrina Glazebrook, et al. "Comparison of Conventional Xrays with CT Based Approaches for Detection of Lytic Lesions in Multiple Myeloma." Blood 136, Supplement 1 (2020): 27–28. http://dx.doi.org/10.1182/blood-2020-138686.

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Background: Lytic bone lesions are one of the most common clinical characteristics of patients with multiple myeloma (MM) and identification of bone lesions help distinguish between patients with smoldering multiple MM and active MM. Given this, the most recent update of the diagnostic criteria for MM incorporates advanced imaging approaches for distinguishing between the two entities. Several small retrospective studies have compared conventional skeletal survey (SS) with whole-body low dose computed tomography (WBLDCT) scan or the CT portion of a positron emission tomography (PET) scan. Cond

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De Jongh, J., R. Hemke, G. C. J. Zwezerijnen, et al. "POS1071 [18F]FLUORIDE PET-CT SCANS VISUALIZE BOTH AXIAL AND PERIPHERAL BONE FORMATION IN PSORIATIC ARTHRITIS PATIENTS." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 859–60. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1259.

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BackgroundPsoriatic arthritis (PsA) can present with peripheral (i.e. arthritis, enthesitis, dactylitis) and/or axial (spondyloarthritis) manifestations. Positron Emission Tomography (PET) may be a promising imaging technique for detection of whole body disease activity since it combines quantification and picomolar sensitivity for accurate depiction of pathologic processes with anatomical low dose CT imaging as a reference (3, 4). It was recently demonstrated that [18F]Fluoride PET-CT scans can successfully visualize and monitor ankylosing spondylitis disease activity by imaging of bone forma

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Giollo, A., G. Vinco, G. Orsolini, et al. "AB1094 SCAR IMAGING ECHOCARDIOGRAPHY WITH ULTRASOUND MULTI-PULSE SCHEME [eSCAR] FOR THE DETECTION OF MYOCARDIAL FIBROSIS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS: PRELIMINARY RESULTS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1836.2–1836. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5006.

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Background:Myocardial fibrosis is a severe complication of immune-mediated diseases, occurring in up to 30% of systemic lupus erythematosus (SLE) patients. Cardiovascular magnetic resonance imaging allows myocardial scar detection in SLE patients, but it is costly, time consuming, and unfit for patients with renal disease. Scar imaging echocardiography with ultrasound multi-pulse scheme (eSCAR) is a novel and promising technique that proved to be effective in detecting ischemic myocardial scars in patients with coronary artery disease (CAD).Objectives:To evaluate if the eSCAR technique is feas

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Harwood, Vanessa, Alisa Baron, Daniel Kleinman, Luca Campanelli, Julia Irwin, and Nicole Landi. "Event-Related Potentials in Assessing Visual Speech Cues in the Broader Autism Phenotype: Evidence from a Phonemic Restoration Paradigm." Brain Sciences 13, no. 7 (2023): 1011. http://dx.doi.org/10.3390/brainsci13071011.

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Audiovisual speech perception includes the simultaneous processing of auditory and visual speech. Deficits in audiovisual speech perception are reported in autistic individuals; however, less is known regarding audiovisual speech perception within the broader autism phenotype (BAP), which includes individuals with elevated, yet subclinical, levels of autistic traits. We investigate the neural indices of audiovisual speech perception in adults exhibiting a range of autism-like traits using event-related potentials (ERPs) in a phonemic restoration paradigm. In this paradigm, we consider conditio

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Sims, Matthew, Sahil Khanna, Darrell Pardi, et al. "658. Diagnostic Testing Among Patients with Suspected Recurrent Clostridioides difficile Infection (rCDI) in ECOSPOR III a Phase 3 Clinical Trial: Implications for Clinical Practice vs Clinical Trials." Open Forum Infectious Diseases 8, Supplement_1 (2021): S431. http://dx.doi.org/10.1093/ofid/ofab466.855.

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Abstract Background Accurate diagnosis of rCDI is challenging because of limitations in test performance and alternative causes of recurrent diarrhea, such as post-infectious irritable bowel syndrome (IBS). Stool enzyme immunoassay (EIA) toxin testing (TOX) is the best predictor of active disease, but may miss cases of CDI when toxins are below the limit of detection. In contrast, glutamate dehydrogenase (GDH) or PCR have high sensitivity but cannot differentiate colonization from infection, leading to possible overdiagnosis due to low specificity. In ECOSPOR III, SER-109, an investigational p

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Paul, Shuvo Kumar, Mircea Nicolescu, and Monica Nicolescu. "Enhancing Human–Robot Collaboration through a Multi-Module Interaction Framework with Sensor Fusion: Object Recognition, Verbal Communication, User of Interest Detection, Gesture and Gaze Recognition." Sensors 23, no. 13 (2023): 5798. http://dx.doi.org/10.3390/s23135798.

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With the increasing presence of robots in our daily lives, it is crucial to design interaction interfaces that are natural, easy to use and meaningful for robotic tasks. This is important not only to enhance the user experience but also to increase the task reliability by providing supplementary information. Motivated by this, we propose a multi-modal framework consisting of multiple independent modules. These modules take advantage of multiple sensors (e.g., image, sound, depth) and can be used separately or in combination for effective human–robot collaborative interaction. We identified and

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Gerver, David, Patricia E. Longley, John Long, and Sylvie Lambert. "Selection Tests for Trainee Conference Interpreters." Meta 34, no. 4 (2002): 724–35. http://dx.doi.org/10.7202/002884ar.

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Abstract This preliminary study devised and tested a series of psychometric tests to facilitate selection of simultaneous and consecutive interpreter-trainee candidates. Twelve tests, based either on text materials, linguistic subskills or speed-stress, were correlated with judges' ratings of the final interpretation examination. Students who passed the exam had higher mean scores on all tests than those who failed. Test scores were positively inter-correlated between completion-detection tests and simultaneous interpretation ratings and between recall tests and consecutive examination ratings

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Bruni, C., L. Tofani, H. Fretheim, et al. "POS0388 DEVELOPING A SCREENING TOOL FOR THE DETECTION OF INTERSTITIAL LUNG DISEASE IN SYSTEMIC SCLEROSIS: THE ILD-RISC RISK SCORE." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 449–50. http://dx.doi.org/10.1136/annrheumdis-2022-eular.2722.

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BackgroundHigh resolution computed tomography (HRCT) is the gold standard for the diagnosis of systemic sclerosis associated interstitial lung disease (SSc-ILD). Although there is agreement in performing HRCT as a screening test at time of SSc diagnosis, some physicians do not regularly perform baseline HRCTs. In addition, it is unclear according to which criteria HRCTs should be repeated during the follow-up of baseline ILD negative patients.ObjectivesTo develop a risk score for the presence of SSc-ILD (the ILD-RISC), to guide physicians in ordering both baseline and follow-up HRCTs.MethodsTh

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Napolitano, Mariasanta, Simona Raso, Maria Francesca Mansueto, et al. "Combined Point of Care Tools Are Able to Improve Treatment Adherence and Health-Related Quality of Life in Patients with Severe Hemophilia: An Observational Prospective Study." Blood 134, Supplement_1 (2019): 3455. http://dx.doi.org/10.1182/blood-2019-128129.

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Introduction: Ultrasound (US) assessment of joints is an evolving point of care tool for the detection of early joint arthropathy (Napolitano M, Kessler CM. Hemophilia A and B. Consultative Hemostasis and Thrombosis, Kitchens, 4th edition); population pharmacokinetic (pop-PK) studies are adopted as a useful instrument to set the prophylaxis regimen for patients with hemophilia, they may improve adherence (Nagao A.et al. Thromb Res. 2019 Jan; 173:79-84) and reduce the annual bleeding rate (ABR). Adherence to continuous intravenous administrations of factor VIII or Factor IX products is challeng

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Gigante, L., D. Bruno, V. Feudo, et al. "THU0306 ROLE OF 18-FDG PET/CT IN DIAGNOSIS AND FOLLOW UP OF LARGE VESSELS VASCULITIS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 381.1–382. http://dx.doi.org/10.1136/annrheumdis-2020-eular.6176.

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Background:18-FDG PET/CT is a functional imaging method which allows to identify inflammation of vessel walls. The use of PET in large vessels vasculitis(LVV) at disease onset and during follow up is still debate either to confirm clinical remission either to drive the therapy choice. American Society of Nuclear Cardiology (ASNC) recently advanced recommendations aimed to standardize the application of PET in LVV(1).Objectives:The aim of our study was to assess the clinical role of PET performed in patients affected by LVV at the diagnosis and during the follow up.Methods:We retrospectively ev

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De Jongh, J., G. C. J. Zwezerijnen, R. Hemke, et al. "POS0898 EARLY DETECTION OF ANTI-TNF INDUCED CHANGES IN NEW BONE FORMATION IN PSORIATIC ARTHRITIS PATIENTS BY¹⁸F-FLUORIDE PET-CT." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 757–58. http://dx.doi.org/10.1136/annrheumdis-2023-eular.869.

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BackgroundNew bone formation in psoriatic arthritis (PsA) can be observed in all musculoskeletal disease domains and can lead to disability due to ankylosis and bridging syndesmophytes [1, 2]. The positive effect of anti-tumor necrosis (anti-TNF) therapy on radiographic damage (e.g. erosion and joint space narrowing) is well known, but there are contradictory findings on its effects on new bone formation [3, 4]. Imaging of new bone formation in PsA is pivotal in order to ascertain the extent and potential therapeutic effects on structural changes at an early stage of treatment. Our group recen

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Roux, C., E. Delannoy, M. Cremoni, et al. "AB0110 FEASIBILITY OF AN IL-17A ASSAY IN PATIENTS WITH ACTIVE AXIAL SPONDYLOARTHRITIS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1234.1–1234. http://dx.doi.org/10.1136/annrheumdis-2023-eular.4401.

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BackgroundIn Spondyloarthritis (SpA), the method of determination of IL-17 is questionable. Indeed, studies measuring plasma levels of IL-17A without stimulation have shown discordant results.ObjectivesThe objective of our study is to show the validity of an IL17 assay method using both innate and acquired immunity stimulation.MethodsWe included volunteer SpAs presenting for consultation between February 2021 and March 2022 in the study. They were axial SpA meeting the ASAS criteria, naïve to any biological treatment, having failed at least two NSAIDs and in need of biological treatment. The c

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Kobayashi, Masayuki, Nobuhiro Ohno, Tomofusa Fukuyama, Toyotaka Kawamata, Kaoru Uchimaru, and Arinobu Tojo. "BRAF-V600E Mutation on Circulating Cell-Free DNA Is a Promising Biomarker of High-Risk Adult Langerhans Cell Histiocytosis." Blood 124, no. 21 (2014): 3209. http://dx.doi.org/10.1182/blood.v124.21.3209.3209.

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Abstract Background: Langerhans cell histiocytosis (LCH) is a rare disorder characterized by clonal proliferation of Langerhans cells and significant infiltration of immune cells. Although the precise pathophysiology is to be elucidated, oncogenic BRAF-V600E mutation could be detected in LCH lesions from the majority of patients (Badalian-Very, et al. Blood. 2010). Furthermore, Berres ML et al. found that patients with active, high-risk LCH carried BRAF-V600E in circulating CD11c+/CD14+ cell fractions. In patients with various kinds of cancers, circulating cell-free DNA (cfDNA) in peripheral b

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Shumnalieva, R., D. Kachakova, R. Kaneva, Z. Kolarov, and S. Monov. "POS0578 CORRELATION BETWEEN EXPRESSION LEVELS OF MIR-155 AND MIR-223 IN SYNOVIAL FLUID AND ULTRASOUND SCORES FOR ACTIVE SYNOVITIS IN RHEUMATOID ARTHRITIS PATIENTS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 522.3–523. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3828.

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Background:MicroRNAs (miRNAs) are a class of small, non-coding RNAs that negatively regulate gene expression at posttranscriptional level. In rheumatoid arthritis studies have shown that miRNA are differentially expressed systemically as well as locally in the inflamed joints [1,2]. The correlation between their systemic or local expression levels and scores for disease activity and progression in RA make them possible candidate for biomarkers in the clinical practice.Objectives:To analyze the expression levels of miR-155 and miR-223 in synovial fluid (SF) from RA patients in regard to the ult

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Hawkes, Eliza A., Geoffrey Chong, Charmaine Smith, et al. "Safety and Efficacy of Induction and Maintenance Avelumab Plus R-CHOP in Patients with Diffuse Large B-Cell Lymphoma (DLBCL): Analysis of the Phase II Avr-CHOP Study." Blood 136, Supplement 1 (2020): 43–44. http://dx.doi.org/10.1182/blood-2020-136024.

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Background: Novel strategies are needed to improve upon the 60% cure rate of upfront R-CHOP in advanced DLBCL. Single-agent immune checkpoint inhibition (ICI) has limited efficacy in heavily pre-treated DLBCL (response rate &lt;10%, Ansell JCO 2019), potentially due to residual immunocompromise from prior therapy. Frontline ICI, given when host immunity is relatively intact, may improve these outcomes. Concurrent ICI with R-CHOP is safe (Smith BJH 2020) but corticosteroid-related immunosuppression may negate ICI efficacy. These factors, along with evidence that ICI sensitises non-Hodgkin l

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Arai, Ayako, Masahide Yamamoto, Maho Sato, et al. "The Outcomes of Systemic Chronic Active EBV Infection Treatment By Allogeneic Hematopoietic Stem Cell Transplantation: An Analysis of Japanese Registry Data." Blood 138, Supplement 1 (2021): 3965. http://dx.doi.org/10.1182/blood-2021-147046.

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Abstract Background and aims Systemic chronic active Epstein-Barr virus infection (sCAEBV) is classified as T- or NK-cell neoplasms in the WHO classification revised in 2017. Although allogeneic stem cell transplantation (allo-HSCT) is efficacious for sCAEBV, the effects are yet to be analyzed in a large number of cases due to the disease rarity. To investigate the outcomes and the prognostic factors of allo-HSCT in sCAEBV under the definition of the WHO 2017 classification, we analyzed retrospectively using the database of Japanese Society for Transplantation and Cellular Therapy (JSTCT). Met

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Cilloni, Daniela, Enrico Bracco, Sonia Carturan, et al. "Design and Application of a Novel PNA Probe for the Detection At a Single Cell Level of BCR-ABL T315I Mutation in Chronic Myeloid Leukemia Patients." Blood 120, no. 21 (2012): 3732. http://dx.doi.org/10.1182/blood.v120.21.3732.3732.

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Abstract Abstract 3732 Background: The BCR-ABL T315I mutation at the gatekeeper residue is frequent in advanced phases of chronic myeloid leukemia (CML) and is one of the main cause of resistance to Tyrosine Kinase Inhibitors (TKI) by disrupting important contact points between the drugs and the enzyme. Although this mutation can be detected by different techniques and at different levels of the mutated clone, the prognostic significance of the absolute amount of the mutated allele is widely unknown. The aim of the study was to develope a novel assay based on peptide nucleic acid (PNA) technol

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Dimier, Natalie, Paul Delmar, Carol Ward, et al. "A Model for Predicting Effect of Treatment on Progression-Free Survival Using Minimal Residual Disease As a Surrogate Endpoint in Chronic Lymphocytic Leukemia." Blood 126, no. 23 (2015): 720. http://dx.doi.org/10.1182/blood.v126.23.720.720.

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Abstract Introduction The standard primary endpoint in clinical trials of chronic lymphocytic leukemia (CLL) is progression-free survival (PFS). Given the increasingly long follow up required to detect differences in PFS between treatment arms in the era of more efficient therapeutics, valid surrogate endpoints are urgently needed to reduce clinical trial duration, thereby accelerating drug development, reducing costs and allowing patients (pts) earlier access to novel treatment options. Pts with CLL who achieve levels of minimal residual disease (MRD) of <1 clonal cell/10.000 leukocytes in

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McIlroy, Graham, Neil Smith, Anand Lokare, Karen Beale, and Charalampos Kartsios. "Treatment Failure in Patients Receiving Direct Oral Anticoagulants: Clinical Management and Outcomes from a Single-Center Review of 59 Consecutive Patients." Blood 132, Supplement 1 (2018): 5058. http://dx.doi.org/10.1182/blood-2018-99-111108.

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Abstract Several direct oral anticoagulants (DOACs) have been developed that dose-dependently inhibit thrombin or activated factor X and offer potential advantages over vitamin K antagonists (VKAs), such as rapid onset and offset of action, absence of an effect of dietary vitamin K intake on their activity, and fewer drug interactions. DOACs have gained in popularity for the treatment and prevention of recurrence of venous thromboembolism (VTE), and the prevention of stroke/systemic embolism in patients with non-valvular atrial fibrillation (AF). However, the lack of routine monitoring means t

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Claudiani, Simone, Carolina Rosadas, Myra McClure, et al. "Prevalence of Sars-Cov-2 Infection in Patients with Chronic Myeloid Leukemia." Blood 136, Supplement 1 (2020): 20. http://dx.doi.org/10.1182/blood-2020-142454.

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Background: The new SARS-CoV-2-induced disease (COVID-19) pandemic has represented a huge challenge for the health systems and has been responsible for almost 700.000 deaths worldwide as of 1st August 2020. Older age, male sex, comorbidities, ethnicity and socioeconomic factorsare risk factors for severe COVID-19. While the direct effect of solid cancer on the COVID-19 outcome has been investigated and is still debated, limited information is available on the impact of an underlying hematological malignancy on the risk of contracting SARS-CoV-2, the clinical presentation and the outcome of the

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Lasa, C., J. S. Osorio Chavez, D. Martínez-López, et al. "AB1650 LATENT TUBERCULOSIS INFECTION IN PATIENTS WITH RHEUMATIC IMMUNE-MEDIATED DISEASES: PREVALENCE AND SCREENING STRATEGY." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 2060.1–2060. http://dx.doi.org/10.1136/annrheumdis-2023-eular.5674.

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BackgroundPatients with rheumatic immune-mediated diseases (R-IMID) with latent tuberculosis infection (LTBI) requiring biologic therapy (BT) are at an increased risk of active tuberculosis (TB). The prevalence of LTBI in patients with R-IMID varies depending on geographical location.An accurate diagnosis and prophylactic treatment of LTBI is crucial to reduce the risk of developing TB. No definitive gold standard exists for diagnosing LTBI. Tuberculin skin test (TST) and interferon-γ release assays (IGRAs) are the most used tests.ObjectivesTo assess:a) Prevalence of LTBI in patients with (R-I

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