Dissertations / Theses on the topic 'Activity therapy'
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Ralph, Christina. "Modulation of T regulatory activity for cancer therapy." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/modulation-of-t-regulatory-activity-for-cancer-therapy(7e39408d-9790-4a0e-9fa2-b6b065f2265e).html.
Full textHedman, Elliott B. (Elliot Bruce). "In-situ measurement of electrodermal activity during occupational therapy." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/62116.
Full textCataloged from PDF version of thesis.
Includes bibliographical references (p. 59-61).
Physiological arousal is an important part of occupational therapy for children with Sensory Processing Disorder (SPD) but therapists do not have a way to objectively measure how therapy affects arousal. We hypothesized that when children with SPD participate in guided activities within an occupational therapy setting, informative changes in electrodermal activity (EDA) can be detected using iCalm. iCalm is a small, wireless sensor developed at MIT that measures EDA and motion, worn on the wrist or above the ankle. Twenty-two children (ages 3-10) with a clinical diagnosis of SPD participated. EDA was measured from the backs of the children's ankles. Concurrent video recordings allowed for comparison of therapeutic activities and children's EDA. Overall, we measured 77 therapy sessions. All measurements were in-situ, during regularly scheduled therapy sessions. Statistical analysis describing how equipment affects EDA was inconclusive, suggesting that many factors play a role in how a child's EDA changes. Case studies provided examples of how occupational therapy affected children's EDA. This is the first study of the effects of occupational therapy's in-situ activities using continuous physiologic measures. The results suggest that careful case-study analyses of the relation between therapeutic activities and physiological arousal may inform clinical practice.
by Elliott B. Hedman.
S.M.
O'Grady, Susan. "Symbolic work with clay as a technique with a difficult to reach patient: a Jungian perspective." Thesis, University of the Western Cape, 2007. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_5934_1223642323.
Full textThis thesis explored the potential of clay work and its symbolic representations as a means to facilitate the integration and individuation of the self in psychotherapy, using a Jungian theoretical framework. A case study methodology was used, to explore a long standing pattern of environmental failure and trauma in a 16 year old female. The Edward's clay work method was utilized to guide the use of the clay work and the discussion and exploration thereof. Central to the study was the importance of a search for meaning given to each clay piece, which was achieved through a dialectical interaction and mutual exploration between therapist and client.
Packman, Jill. "Group activity therapy with learning disabled preadolescents exhibiting behavior problems." Thesis, University of North Texas, 2002. https://digital.library.unt.edu/ark:/67531/metadc3326/.
Full textKissane, Roger William Peter. "Animal models of exercise therapy : mechanisms of activity-induced angiogenesis." Thesis, University of Leeds, 2017. http://etheses.whiterose.ac.uk/17587/.
Full textClarke, Kerry. "Physical activity referral schemes : adherence and physical activity behaviour change." Thesis, University of Northampton, 2013. http://nectar.northampton.ac.uk/7483/.
Full textYousef, Dina K. "Group Activity Play Therapy for Preadolescents: Effects on Low Self-Esteem." Thesis, University of North Texas, 2016. https://digital.library.unt.edu/ark:/67531/metadc862864/.
Full textAsano, Miho. "Promoting exercise and physical activity among persons with multiple sclerosis." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=97039.
Full textLa sclérose en plaques (SP) est une maladie neurologique progressive qui afflige principalement les jeunes adultes en Amérique du Nord et majoritairement les femmes. La SP a peu d'effet sur la durée de vie, mais a un effet significatif sur la qualité de vie. Bien que les bénéfices de l'exercice soient connus, il a été démontré que les personnes atteintes d'une maladie chronique, telle que la SP, sont physiquement moins actives. Considérant ces faits, une compréhension profonde des personnes atteintes de SP, de leur engagement face à l'exercice et de leur préoccupation représente une première étape cruciale. La première partie de cette thèse présente les preuves existantes ainsi que les problèmes méthodologiques associés aux études contrôlées randomisées qui mesurent l'effet des interventions impliquant l'exercice chez les personnes atteintes de SP. La seconde partie identifie les engagements actuels face à l'exercice, les préférences ainsi que les barrières de 417 personnes atteinte de SP vivant dans la communauté ambulatoire. Un sous-groupe de cette population a participé à des entrevues semi-structurées et ont donné leur avis sur l'élaboration d'un programme d'exercices. Cette information a été utilisée pour le développement de la phase suivante de ce projet – un projet pilot contrôlé randomisé évaluant la faisabilité et l'efficacité d'un programme d'exercices personnalisés pour la SP (« Multiple Sclerosis Tailored Exercise Program (MSTEP) ». Le développement du MSTEP est aussi démontré dans la troisième partie de cette thèse. La quatrième et dernière section présente le cas de deux participants ayant complété toutes les phases du programme MSTEP. Les résultats des études démontrent que les préférences ainsi que les barrières de l'exercice peuvent être associées avec la décision de chacun d'être physiquement actif ou non. Les données disponibles sur l'étude pilote en cours portant sur le MSTEP présentent des résultats supportant sa faisabilité (et un certain niveau d'efficacité) tant sur le point de vue des participants que celui scientifique. De plus, la nature favorable des informations qualitatives recueillies de la part des participants ainsi que l'absence de blessures rapportées, d'accidents ou d'extrême fatigue dû à l'exercice, amplifient notre confiance dans le MSTEP et sa capacité de promouvoir une vie active et une bonne santé dans cette population.
Lela, Mukaruzima. "The relationship between physical activity and low back pain among nurses in Kanombe Military Hospital." Thesis, University of the Western Cape, 2010. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_3554_1307534535.
Full textThe aim of the current study was to determine the relationship between low back pain and physical activity levels among nurses in Kanombe Military Hospital (KMH), as well as other confounding factors leading to low back pain. A quantitative, cross-sectional and descriptive design was used to conduct the study. The study population and sample included all clinical nurses in all the departments/wards at KMH (excluding three nurses doing administrative work only and the four who participated in the pilot study). A total of 133 nurses participated in the study and data was collected using three self administered questionnaires. The first one requested socio-demographic data, followed by the International Physical Activity Questionnaire (IPAQ) which examined the physical activity levels of nurses, and lastly the Nordic Musculoskeletal Disorder Questionnaire which examined low back pain prevalence. A response rate of 122 (92%) was obtained.
Gill, Elizabeth C. M. S., Suzanne Ph D. Phelan, Marni Ph D. Goldenberg, and Heather Ph D. Starnes. "Outdoor Adventure Therapy to Increase Physical Activity in Young Adult Cancer Survivors." DigitalCommons@CalPoly, 2015. https://digitalcommons.calpoly.edu/theses/1354.
Full textTshangana, Charmaine Sesethu. "Photo-physicochemical studies and photodynamic therapy activity of indium and gallium phthalocyanines." Thesis, Rhodes University, 2015. http://hdl.handle.net/10962/d1017928.
Full textBigras, Cristina. "Physical Activity and Cognitive Function in Focal Epilepsy." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1445342117.
Full textBorushok, Jessica E. "Get ACTive! A pilot acceptance and commitment therapy workshop." Bowling Green State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1492125819743085.
Full textLundgren, Stina. "Pain and physical activity in rheumatoid arthritis : a cognitive approach in physical therapy /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-371-x/.
Full textWang, Chao. "Theranostic mercury: 197(m)Hg with high specific activity for imaging and therapy." Doctoral thesis, Technische Universität Dresden, 2018. https://tud.qucosa.de/id/qucosa%3A32758.
Full textFirrman, Jenni Ann. "ENHANCEMENT OF hFVIII ACTIVITY THROUGH LC MODIFICATIONS FOR GENE THERAPY OF HEMOPHILIA A." Diss., Temple University Libraries, 2015. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/335863.
Full textPh.D.
Gene therapy for Hemophilia A (HA) using the recombinant Adeno-associated virus (rAAV) offers an alternative to classic treatment, which consists of FVIII protein infusions. However, due to limitations associated with rAAV and the FVIII protein itself, the end result is a transgene expression below therapeutic limits. One approach to improving the therapeutic value of rAAV gene therapy for HA is to engineer a more active FVIII protein through genetic modifications. Preliminary testing revealed that canine FVIII Light Chain (kLC) enhances coagulation activity, and that it would be possible to improve FVIII activity through modifications of the light chain. Through the process of engineering, evaluation, and negative selection of kLC, a final construct was engineered. The hLC-K12 is a human Light Chain (hLC) construct containing 12 amino acid changes that work together to enhance coagulation activity. A comparison of the FVIII clotting activity to the amount of protein produced determined that hLC-K12 produced a 3.28 fold increase in specific activity over hLC in vitro. Similar in vitro results were observed when hLC-k12 was tested with the X5 heavy chain (X5HC), a heavy chain that has been genetically modified to enhance production. CD4KO/HA mice were injected with a rAAV vector carrying the hLC-K12 gene in conjugation with a rAAV vector carrying the X5HC gene. Replacing the hLC vector with the hLC-K12 vector produced an average 7.43 fold increase in FVIII clotting activity. An ELISA assay revealed no significant difference between productions of the heavy or light chains at any time point. By comparing the clotting activity to the amount of protein produced, it was determined that the increase in coagulation activity was due to an increase in specific activity. In fact, replacing the hLC vector with the hLC-K12 vector resulted in an average 5.8 fold increase in FVIII specific activity. The K12 modifications were evaluated using a single chain FVIII conformation. In vitro, the addition of the K12 mutations to the human heavy chain, hHCK12BDD, resulted in a 4.3 fold increase in clotting activity, but no increase in protein production. There was however, a 3.3 fold increase in specific activity of the protein. Adding the K12 mutations to the X5 heavy chain, X5K12BDD, in vitro, resulted in a 2.7 fold increase in clotting activity and a 1.42 fold increase in specific activity of the protein. Single chain rAAV vectors were packaged and delivered to CD4KO/HA mice. Compared to mice injected with hFVIIIBDD, the hHCK12BDD produced an average 4.6 fold increase in clotting activity. An ELISA revealed no significant difference in production between these two groups. However, mice injected with hHCK12BDD produced FVIII with an average of 4.13 fold increase in specific activity. Similarly, when compared to mice injected with X5FVIIIBDD, the X5K12BDD produced an average 2.14 fold increase in clotting activity. An ELISA assay demonstrated no significant increase in protein production between these two groups. However, when compared to X5BDD, mice injected with the X5K12BDD vector produced FVIII with an average 1.98 fold increase in specific activity. Results demonstrate that the K12 light chain modifications are able to enhance clotting activity of hFVIII both in vitro and in vivo, using either a dual chain or single chain delivery method. In order to determine the mechanism of enhancement, hFVIIIBDD and hHCK12BDD protein was partially purified and tested for activity. Results demonstrated that the hHCK12BDD protein produced a specific activity of 39,153.69 Units/mg, which is a 6.28 fold increase over hFVIIIBDD specific activity, which was 6,237.92 Units/mg. Measurement of conversion from FX to FXa revealed that the hHCK12BDD protein generated a higher amount of FXa at a quicker rate. In conclusion, these results provide evidence that the K12 modifications enhance specific activity through an increase in FXa generation.
Temple University--Theses
Howerton, Brock S. "Design, Synthesis, and Anticancer Activity of Ruthenium Complexes." UKnowledge, 2012. http://uknowledge.uky.edu/chemistry_etds/10.
Full textLiu, Jian. "POLYMER MODIFICATION OF FULLERENE FOR PHOTODYNAMIC TUMOR THERAPY AND TUMOR IMAGING." 京都大学 (Kyoto University), 2010. http://hdl.handle.net/2433/120886.
Full textCarlsvärd, Oscar, and Ruth Karlsson. "Svensk version av bedömningsinstrumentet Weekly Calendar Planning Activity (WCPA) - normdata för vuxna personer 18-50 år." Thesis, Örebro universitet, Institutionen för hälsovetenskaper, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-51307.
Full textPoliachik, Sandra Louise. "An investigaton of the mechanisms of high intensity focused ultrasound induced platelet activity /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/8011.
Full textHilton, Claudia. "Relationship of motor skills and social skills to out-of-school activity participation patterns in children with Asberger Syndrome." Diss., NSUWorks, 2006. https://nsuworks.nova.edu/hpd_ot_student_dissertations/19.
Full textGehrman, Christine Amerika. "Effects of a physical activity and nutrition intervention on body image in pre-adolescents /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2003. http://wwwlib.umi.com/cr/ucsd/fullcit?p3083465.
Full textYen, Chu-Ling. "Influence of age, physical activity, and motor cortical excitability on neuromuscular control of the wrist in humans." Diss., University of Iowa, 2016. https://ir.uiowa.edu/etd/2298.
Full textAndersson, Maja, and Anna-Madonna Beydoun. "Normdata för den svenska versionen av Weekly Calendar Planning Activity (WCPA) för personer mellan 51 - 70 år." Thesis, Örebro universitet, Institutionen för hälsovetenskaper, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-56823.
Full textAbayaweera, Gayani Sandeepa. "Diverse use of iron oxide nanoparticles for anticancer therapy." Diss., Kansas State University, 2014. http://hdl.handle.net/2097/17564.
Full textDepartment of Chemistry
Stefan H. Bossmann
Recent development of a variety of superparamagnetic and ferromagnetic iron/iron oxide (Fe/Fe₃O₄) nanoparticles with different surface chemistry have been widely studied for numerous biological applications such as drug delivery, as diagnostics, hyperthermia and magnetic resonance imaging. The wide applications of Fe/Fe₃O₄ nanoparticles are possible since they exhibit favorable properties as high magnetization ability, are smaller than 100 nm in size, they can be coated with several ligands which allow drug delivery at a specific site and are biocompatible. By using Fe/Fe₃O₄ nanoparticles as drug delivery agents treatment costs and side effects can be reduced, however treatment efficacy can be increased. We have demonstrated that Fe/Fe₃O₄ nanoparticles can be utilized in different methods depending on their properties, to be used as therapeutic agents for cancer treatment. In one method we have taken advantage of the Fe/Fe₃O₄ nanoparticles magnetic ability to produce hyperthermia (heat) in cancer cells when subjected to an alternative magnetic field. Here we use the cell based delivery system since the size of the nanoparticles are small they can be taken up by monocyte/ macrophage like cells for systemic transportation to the inflamed cancer cite. The hyperthermia study was conducted in mice with pancreatic cancer. This study demonstrated that the life expectancy of the mice increased by 31%. In the next method we took the advantage of the surface chemistry of the Fe/Fe₃O₄ nanoparticles and changed it with dopamine-peptide and dopamine-thiosemicarbazone ligands. The advantage of the peptide is to deliver the nanoparticle to its target site and the thiosemicarbazone analogue is used as an iron chelator that would initiate apoptosis in cancer cells. This nanoplatform was tested in 4T1 breast cancer cell line and normal fibroblast cell line and demonstrated that it was effective towards the cancer cell line than the normal cell line at a ratio of 5:1 of thiosemicarbazone analogue : dopamine on the nanoparticle. However further studies are needed to be done to clarify the effectiveness of this nanosystem.
Gundel, Friederike [Verfasser]. "Mindfulness Training in Dialectical Behavior Therapy Investigation on Brain Activity by NIRS / Friederike Gundel." Tübingen : Universitätsbibliothek Tübingen, 2021. http://d-nb.info/1234450879/34.
Full textAlok, Kumar. "Tumors attenuating the mitochondrial activity in T cells escape from PD-1 blockade therapy." Kyoto University, 2020. http://hdl.handle.net/2433/254514.
Full textEngström, Niklas, and Hanna Näsholm. "The meaning of activity amongst women participating in a craft group in South Africa." Thesis, Örebro universitet, Hälsoakademin, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-8962.
Full textSyftet med denna uppsats var att beskriva betydelsen av aktivitet hos en grupp kvinnor som deltar i en hantverksgrupp i Sydafrika. En kvalitativ metod användes för att besvara syftet med studien. Tio afrikanska kvinnor som bor i kåkstäder utanför Pretoria intervjuades. Intervjuerna genomfördes utifrån en utarbetad intervjuguide innehållande semistrukturerade frågor. Det insamlade datamaterialet analyserades utifrån en kvalitativ innehållsanalys, som utmynnade i två huvudkategorier med två underkategorier vardera; 1) ”Inre värden” som innehåller ”deltagande i en social aktivitet” och ”ökat självförtroende genom deltagande i aktivitet”, och 2). ”Yttre värden” som innehåller” ”produktivitet” och ”fritidsaktiviteter”. I kategorin Inre värden beskriver deltagarna meningen av att delta i hantverksaktiviteter med ett inifrånperspektiv. Kategorin Yttre värden innehåller beskrivningar som är meningsfulla utanför individen. Den här studien visar att hantverk hade stor betydelse för deltagarna inom flera olika områden som socialt nätverk och personlig utveckling. Betydelsen av hantverk inom arbetsterapi behöver studeras ytterligare och det vore intressant att genomföra en liknande studie i Sverige.
Ericson, Annelie, and Olivia Fredriksson. "Arbetsterapeuters erfarenhet om terapihundar påverkar relationen mellan arbetsterapeut och klient samt klientens delaktighet i aktivitet." Thesis, Luleå tekniska universitet, Institutionen för hälsovetenskap, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-74282.
Full textSyftet med studien var att undersöka omarbetsterapeuter upplever att terapihundarkan påverkarelationen till klienten samtklientensdelaktighet i aktivitet. Metodensom användes var en kvalitativ studie med tiodeltagare som kontaktades via rekommendationer och via det sociala nätverket Facebook. Frågorna berörde arbetsterapeuternas upplevelse kring att arbeta med terapihund och deras erfarenheter om huruvida terapihunden kan vara ett hjälpmedel för att hjälpa till att skapa relation till klienten och motivera till aktivitet. Resultatetvisade att erfarenheterna var övervägande positiva och att terapihunden gjorde att klientkontakten blev starkare. Arbetsterapeuterna upplevde att de kunde komma längre i sina interventioner med hjälp av hunden och att klienterna öppnade upp sig mer och var mer motiverade till att delta i aktiviteter närhunden var närvarande.Det visade också att utbildning, planering, målsättning och journalföring var viktigt för att visa på terapihundarnas effekt.Slutsats: Resultatet visade positiva situationer där terapihunden varit ett hjälpmedel för arbetsterapeuternas framgång i interventionen. Studien visade att kontakten till klienten stärktes med hjälp av terapihunden och att motivationen att delta i aktiviteter ökade
Levin, April Robyn. "Early Seizure Blockade: Preventing Long-Term Epileptic Activity in Wag/Rij Rats." Yale University, 2008. http://ymtdl.med.yale.edu/theses/available/etd-08152007-130206/.
Full textKriviraltcheva-Kaneva, Pepa. "Validity of CHAMPS physical activity questionnaire as an indicator of the process of surgical recovery." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101153.
Full textThe surgical population is unique, as it comprises people diverse in age and functioning. The data for this study were obtained from a randomized control trial (RCT) evaluating the impact of a presurgical period of physical conditioning on surgical recovery following scheduled colonic resection, termed rehabilitation. Patients were randomized into two groups, Exercise and Control. Cross-sectional and longitudinal analyses were conducted at entry into the study, at one-day pre-surgery, and at one- and two-months post-surgery. A sample of 62 subjects participated in this study. The Short Form Health Survey (SF-36) Physical Functioning Scale (PF) and Physical Component Summary Score (PCS), VO2max and 6MWT were low to moderately correlated with the CHAMPS questionnaire at the same time points. For the Exercise group, energy expenditure as estimated using the CHAMPS questionnaire, increased significantly from 2653 to 3957 kcal.wk-1 (p<0.05). Physical activity levels dropped significantly (p<0.001) from pre-surgery (4103 kcal.wk-1) to one month post-surgery (1547 kcal.wk-1); and they were still lower (2396 kcal.wk-1) at two months post-surgery (p<0.01). Older age (>65), cancer diagnosis and female gender were associated with higher drop in physical activity levels at one-month post surgery. Evidence has been provided towards construct known groups, longitudinal (sensitivity to change and responsiveness) and convergent validity of physical activity questionnaire (CHAMPS) as an indicator of the process of surgical recovery. The information obtained from the questionnaire will allow health professionals to better plan care and develop programs to best manage the patients.
Ojiambo, Deborah. "Effectiveness Of Group Activity Play Therapy On Internalizing And Externalizing Behavior Problems Of Preadolescent Orphans In Uganda." Thesis, University of North Texas, 2011. https://digital.library.unt.edu/ark:/67531/metadc103365/.
Full text劉肇妍 and Siu-in Lau. "Evidence-based guideline for increasing physical activity among Chinese older adults with depressive symptoms." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/193071.
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Nursing Studies
Master
Master of Nursing
Slapin, Aurelija. "Source distribution of neuromagnetic slow wave and alpha activity in depressive patients therapy-dependent changes /." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=976799251.
Full textChen, Chiung Chu. "Oscillatory activity in the basal ganglia : is it relevant to movement disorders and their therapy?" Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1446205/.
Full textOjo, Evelyn. "Approaches to Improve the Proliferation and Activity of Natural Killer Cells for Adoptive Cell Therapy." Case Western Reserve University School of Graduate Studies / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1536760957918928.
Full textCooper, Pauline. "The Use of Creative Writing as a Therapeutic Activity for Mental Health in Occupational Therapy." Thesis, University of Sussex, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486992.
Full textTweedy, Sean. "Promoting physical activity among community-dwelling people with acquired brain injury /." [St. Lucia, Qld.], 2005. http://adt.library.uq.edu.au/public/adt-QU20060420.120547/index.html.
Full textSilva, Raquel Sofia de Oliveira Nunes da. "Phthalocyanine-sulfonamide conjugates-synthesis and biological activity." Doctoral thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22842.
Full textO uso inapropriado de antibióticos no tratamento de doenças infeciosas tem levado a um aumento da resistência de diversos microrganismos patogénicos, o que apresenta atualmente um problema de saúde pública e tem motivado a procura de estratégias alternativas para o controlo destes microrganismos. Por outro lado, a procura de novas moléculas ou novas combinações de moléculas para o combate ao cancro é um assunto em constante desenvolvimento. Na presente dissertação descreve-se o trabalho desenvolvido para a obtenção de conjugados de ftalocianina–sulfonamida e a avaliação da atividade dos novos compostos como fotossensibilizadores. Os conjugados foram idealizados com o intuito de promover um possível efeito sinérgico das suas unidades constituintes, nomeadamente propriedades antitumorais e/ou antimicrobianas. Para tal, desenvolveram-se métodos de síntese de sulfonamidas e de conjugados de ftalocianina–sulfonamida. Algumas das ftalocianinas obtidas foram testadas como fotossensibilizadores na eliminação fotodinâmica de células tumorais e de bactérias, utilizando-se as linhas celulares de carcinoma de células escamosas orais (HSC3) e de queratinócitos orais (HaCaT), e as bactérias Escherichia coli (Gram-negativo) Staphylococcus aureus (Gram-positivo) como modelos biológicos. Os resultados destes estudos revelaram que as ftalocianinas estudadas são muito promissoras como fotossensibilizadores para a inativação fotodinâmica de células tumorais e de microrganismos. Por outro lado, foi também desenvolvido um ensaio enzimático para avaliar a atividade dos novos compostos como inativadores da enzima anidrase carbónica, em particular a isoforma IX que se encontra sobre-expressa em células tumorais e é bem conhecida como reguladora do pH em processos de hipoxia e acidose metabólica. Este estudo vem dar mais um passo no conhecimento científico das ftalocianinas e evidencia o potencial das ftalocianinas sulfonadas na perspetiva do controlo de infeções e da tumorogénese.
The inappropriate use of antibiotics in the treatment of infections has led to an increase in the resistance of several pathogenic microorganisms, which represents a major public health issue and triggered the search for novel antimicrobial drugs. On the other hand, the search for new molecules or new combinations of molecules for the fight against cancer is a subject in constant development. The present dissertation describes the work developed to obtain phthalocyanine–sulfonamide conjugates and the biological evaluation of these compounds as photosensitizers. These conjugates were designed to explore their antimicrobial and/or antitumor properties. Methods for the synthesis of sulfonamides and phthalocyanine–sulfonamide conjugates were developed. Some of the phthalocyanines obtained were tested as photosensitizers for the photodynamic inactivation of tumor cells and bacteria. HSC3 oral squamous cell carcinoma, HaCaT 'normal' keratinocytes, and the bacteria Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive) were used as biological models. The phthalocyanines studied proved to be very promising to be considered in future studies in the perspective of the photodynamic inactivation of tumor cells and microorganisms. On the other hand, an enzymatic assay was also developed to evaluate the activity of the compounds obtained as inactivators of the enzyme carbonic anhydrase, in particular the IX isoform that is overexpressed in tumor cells and is well-known as pH regulator in processes of hypoxia and metabolic acidosis. This study represents a contribution to the application of phthalocyanines, and in particular sulfonated phthalocyanines, in the control of infections and tumorigenesis.
Drogkari, Stavroula. "Paediatric Assessments Measuring Children’s and Adolescents’ Perceptions on their Activity Capacity, Performance, and/ or Participation. A Systematic Review." Thesis, Högskolan i Jönköping, Hälsohögskolan, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-45859.
Full textCollier, Abby Cherise. "Expression and activity of enzymes in the human placenta: pharmacological & toxicological consequences in AZT therapy." Thesis, University of Auckland, 2002. http://hdl.handle.net/2292/3138.
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Lewer, Marcelo Henrique Mamede. "Radiolabeling of Avidin with Very High Specific Activity for Internal Radiation Therapy of Intraperitoneally Disseminated Tumors." Kyoto University, 2004. http://hdl.handle.net/2433/147459.
Full textWalker, Wendilywn E. "Towards gene therapy for cystic fibrosis : enhanced green fluorescent protein as a reporter of promoter activity." Thesis, University of Edinburgh, 2005. http://hdl.handle.net/1842/27597.
Full textSerotta, Jennifer Lynn. "Increasing Physical Activity in Post Liver Transplant Patients." UNF Digital Commons, 2014. http://digitalcommons.unf.edu/etd/546.
Full textJohansson, Malin, and Sofia Isaksson. "Smärtans påverkan på fritidsaktiviteter : En intervjustudie med personer med fibromyalgi." Thesis, Hälsohögskolan, Högskolan i Jönköping, HHJ, Avd. för rehabilitering, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-15347.
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Full textBeyer, Sasha Jasmine. "Modulation of Cell Surface Sodium/Iodide Symporter Expression and Activity in Breast Cancer." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1282141972.
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