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Dissertations / Theses on the topic 'Acute and chronic bronchitis'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Sousa, Clóvis Arlindo de. "Doenças respiratórias e fatores associados: Inquérito de Saúde no Município de São Paulo ISA-CAPITAL 2008." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/6/6132/tde-09092011-110323/.

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Introdução - As doenças respiratórias - asma, doença pulmonar obstrutiva crônica (DPOC), rinite alérgica, sinusite e bronquite aguda - estão entre as principais causas de morbidade, mortalidade e de encargos financeiros para população e para o sistema de saúde. Objetivo - Estimar a prevalência e os fatores associados às doenças respiratórias no município de São Paulo entre 2008 e 2009. Métodos - Estudo transversal, de base populacional, utilizando-se os dados do Inquérito de Saúde no Município de São Paulo 2008 (ISA-Capital 2008), conduzido de 2008 a 2009, com amostra total de 3.271 pessoas de

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2

Macnee, W. "Right ventricular function in chronic bronchitis and emphysema." Thesis, University of Glasgow, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383973.

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3

Abdirahman, Shire Wardhere. "Risk factors of recurrent acute obstructive bronchitis in children." Thesis, Sumy State University, 2014. http://essuir.sumdu.edu.ua/handle/123456789/36294.

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Broncho-obstructive syndrome (BOS) is the collective term including a symptom-complex of specifically outlined clinical implications of disturbance of bronchial passableness, having in the basis narrowing or an occlusion of respiratory tracts. Broncho-obstructive syndrome is condition, which is accompanied by recurrent attacks of expiratory dyspnea (difficulty to exhale) owing to the spasm of bronchial smooth muscles, edema of bronchi, and increased bronchial secretion. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/36294

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4

Sydorchuk, L. I. "Destabilization of colonic luminal microbiome in chronic obstructive bronchitis." Thesis, БДМУ, 2022. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19718.

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5

Morgan, A. D. "Psychological and physiological factors affecting exercise tolerance in chronic bronchitis." Thesis, University of Edinburgh, 1986. http://hdl.handle.net/1842/19158.

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6

Mabrouk, Ben Othmen. "Features of obstructive syndrome in school-age children with acute bronchitis." Thesis, БДМУ, 2021. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19091.

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7

Mathews, Timothy John. "Acute and acute on chronic mastoiditis : complications and management." Master's thesis, University of Cape Town, 1987. http://hdl.handle.net/11427/26282.

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8

Гавриленко, Анастасія Олександрівна, Анастасия Александровна Гавриленко, Anastasiia Oleksandrivna Havrylenko, et al. "Increase in interleukin-6 response in infants with acute obstructive bronchitis against thymomegaly." Thesis, ALUNA, 2020. https://essuir.sumdu.edu.ua/handle/123456789/81189.

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Мета: вивчити рівень ІЛ-6 в сироватці крові немовлят з гострим обструктивним бронхітом (ГОБ) на тлі тимомегалії (ТМ). Матеріали і методи: Дослідження проводилося на базі Дитячої клінічної лікарні Святої Зінаїди в 2019 році. Було обстежено 24 немовляти з ГОБ. Діти були розділені на дві групи: I група - пацієнти з ГОБ без ТМ (14 дітей); II група - пацієнти з ГОБ з ТМ (10 дітей). Контрольну групу склали 12 здорових немовлят репрезентативного віку і статі. Концентрацію ІЛ-6 в сироватці визначали твердофазним імуноферментним аналізом з використанням тест-систем. Статистична обробка отриманих рез

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9

Mabrouk, Ben Othmen. "The features of clinical manifestations in children with acute obstructive bronchitis and their assessment." Thesis, БДМУ, 2022. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19805.

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10

Atamaniuk, Y. A. "Аdaptation process, level of cellular reactivity and nonspecific reactivity of patients with acute bronchitis". Thesis, БДМУ, 2022. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19706.

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11

Гуріна, С. В. "Особливості клінічного пебебігу гострого бронхіту у дітей раннього віку". Thesis, Сумський державний університет, 2016. http://essuir.sumdu.edu.ua/handle/123456789/48028.

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Актуальність: гострі бронхіти займають провідне місце в нозологічній структурі гострих інфекційно–запальних захворювань нижніх дихальних шляхів у дітей протягом останніх десятиліть. Мета роботи: проаналізувати особливості клінічного перебігу гострого обструктивного бронхіту у дітей раннього віку.

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12

Сміян, Олександр Іванович, Александр Иванович Смиян, Oleksandr Ivanovych Smiian та В. В. Гринишин. "Особливості перебігу гострого бронхіту у дітей раннього віку". Thesis, Вид-во СумДУ, 2007. http://essuir.sumdu.edu.ua/handle/123456789/5649.

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13

Сміян, Олександр Іванович, Александр Иванович Смиян, Oleksandr Ivanovych Smiian та В. В. Гринишин. "Принципи раціональної антибактеріальної терапії гострих бронхітів у дітей раннього віку". Thesis, Видавництво СумДУ, 2010. http://essuir.sumdu.edu.ua/handle/123456789/6347.

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14

O'Reilly, Derek A. "Individual susceptibility to acute & chronic pancreatitis." Thesis, University of Exeter, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486658.

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Aims: To elucidate individual susceptibility to acute and chronic pancreatitis by examining candidate genes: tumour necrosis factor (TNF), cationic trypsinogen (PRSS1) and serine protease inhibitor, Kazal type 1 (SPINK1) in patients with acute and chronic pancreatitis. To examine the role of the transcription factors, nuclear factor-?B (NF-?B) and heat shock factor-1 (HSF-1) in acute pancreatitis. Results: The TNF a6b5c1d3e3 haplotype is positively associated with chronic pancreatitis (OR= 2.08 (95% CI: 1.12-3.88; X2=5.49, P=0.019); the TNF a2b3c1d1e3 and a2b5c2d4e3 haplotypes are negatively a

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15

White, David James. "Haemophilus in acute and chronic respiratory disease." Thesis, Liverpool John Moores University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304425.

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16

Paul-Clark, Mark John. "Nitric oxide in acute and chronic inflammation." Thesis, Queen Mary, University of London, 2002. http://qmro.qmul.ac.uk/xmlui/handle/123456789/1545.

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Nitric oxide (NO) is a signalling molecule formed when L-arginine is converted to L-citrulline by the enzyme NO synthase (NOS. NOS exists as three isoforms, ecNOS is constitutively expressed in endothelial cells and nNOS in neuronal cells, while a third isoform (iNOS) is induced in response to inflammatory stimuli and is capable of sustained production of high levels of NO. NO produced in response to an inflammatory insult, has been shown by use of NOS inhibitors to be detrimental during inflammation by producing the potent oxidising agent peroxynitrite. However, iNOS knockout animals generall

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17

Wei, Jin. "Acute Kidney Injury and Chronic Kidney Disease." Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/6780.

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Ischemia and reperfusion are natural steps during kidney transplantation, and IRI is considered one of the most important nonspecific factors affecting allograft dysfunction. Transplanted organs experience several episodes of ischemia, in which cold ischemia occurs during allograft storage in preservation solutions. Even though cold ischemia has been studied extensively, all of the studies have been carried out in vitro and ex vivo models. There is no in vivo model available to examine renal IRI induced solely by cold ischemia. In the present study, we developed an in vivo mouse model to study

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18

Stone, Michael H., Michael W. Ramsey, Ann M. Kinser, Harold S. O'Bryant, Chris Ayers, and William A. Sands. "Stretching: Acute and Chronic? The Potential Consequences." Digital Commons @ East Tennessee State University, 2006. https://dc.etsu.edu/etsu-works/4133.

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Stretching is commonly used by many athletes in different sports. Although acute stretching, as part of a warm-up, can enhance range of motion, it may also reduce performance. Acute stretching can reduce peak force, rate of force production, and power output. Chronic stretching may enhance performance, although the mechanism is unclear. Acute stretching has little effect on injury. However, chronic stretching (not part of warm-up) may have some injury reduction potential.

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19

Brocca, Alessandra. "Characterization of molecular pathways involved in acute and acute-on-chronic liver disease." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3425355.

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Introduction: Acute decompensation was defined as the acute development of one or more major complications of liver disease and it was the main cause of hospitalization in patients with cirrhosis. The acute-on-chronic liver failure (ACLF) was characterized by acute decompensation of cirrhosis, organ failure and high 28-day mortality. ACLF displayed key features of systemic inflammation and its poor outcome was closely associated with exacerbated systemic inflammatory responses. Inflammasomes were multiprotein complexes which proteolytically activates the cytokines IL-1β and IL-18. These substr

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20

Johnston, William Brent. "Leukocyte recruitment mechanisms in acute and chronic inflammation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0003/NQ38478.pdf.

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21

Dowzer, Clare Natalie. "The acute and chronic effects of water-running." Thesis, Liverpool John Moores University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285283.

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22

Hall, Sara Rachel. "Behavioural effects of acute and chronic viral illnesses." Thesis, Cardiff University, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.588596.

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23

Markham, Jennifer Rose. "Coping styles of chronic pain patients for both acute and chronic pain experiences." Case Western Reserve University School of Graduate Studies / OhioLINK, 1994. http://rave.ohiolink.edu/etdc/view?acc_num=case1057682099.

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24

Плахута, Валентина Анатоліївна, Валентина Анатольевна Плахута, and Valentyna Anatoliivna Plakhuta. "Concentration of leukocyte subpopulation in blood serum of children suffering from acute obstructive bronchitis and thymomegalia." Thesis, Sumy State University, 2014. http://essuir.sumdu.edu.ua/handle/123456789/45392.

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In recent times children suffering from acute obstructive bronchitis (AOB) need increased attention of Ukrainian doctors due to the fact that almost 30% of all patients having respiratory diseases suffer from this pathology. The immune system together with one of its main organs - thymus is one of the main components involved in the pathogenesis of bronchopulmonary diseases because infectious agent acts directly through it. Aim of the study was to investigate the level of CD3+ and CD21+ in serum of young children having acute obstructive bronchitis, depending on the presence of concomitant th

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25

Näsström, Elin. "Diagnosis of acute and chronic enteric fever using metabolomics." Doctoral thesis, Umeå universitet, Kemiska institutionen, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-140188.

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Enteric (or typhoid) fever is a systemic infection mainly caused by Salmonella Typhi and Salmonella Paratyphi A. The disease is common in areas with poor water quality and insufficient sanitation. Humans are the only reservoir for transmission of the disease. The presence of asymptomatic chronic carriers is a complicating factor for the transmission. There are major limitations regarding the current diagnostic methods both for acute infection and chronic carriage. Metabolomics is a methodology studying metabolites in biological systems under influence of environmental or physiological perturba

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26

Horner, Patrick Jacob. "The aetiology of acute and chronic non-gonococcal urethritis." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415156.

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27

Chen, Roy Yu-Wei. "Biomarkers for acute exacerbation of chronic obstructive pulmonary disease." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/57759.

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Rationale: There are currently no generally accepted and validated blood tests available for diagnosing acute exacerbations of chronic obstructive pulmonary disease (AECOPD). There is an urgent need of biomarkers that can guide therapeutic management in AECOPD. Based on literature review, systemic inflammation and mild cardiac dysfunction are often associated with AECOPD. We hypothesized that certain protein markers can indeed be useful in tracking and diagnosing AECOPD progression. Methods: The study cohort consisted of 368 patients recruited in the chronic obstructive pulmonary disease (COP

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28

Sweerts, Bevan William 1975. "Acute and chronic restraint : impact on central neuropeptide systems." Monash University, Dept. of Pharmacology, 2001. http://arrow.monash.edu.au/hdl/1959.1/9012.

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29

Lin, David Chia-Hsiang. "Biomarkers of acute and chronic human heart allograft rejection." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43474.

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Background: Cardiac transplantation is considered the primary therapy for patients with end-stage heart failure. However, the detection of chronic cardiac allograft rejection (expressed as cardiac allograft vasculopathy; CAV) remains an important unsettled issue in cardiac transplantation. The current gold standards for the diagnosis and monitoring of acute rejection and CAV are invasive in nature with risk for complications. From a clinical perspective, more accurate, minimally-invasive alternatives are clearly desirable. The goal of my thesis is to identify biomarkers of human heart allograf

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30

Schroeder, James Lee. "Acute and chronic regulation of oxidative phosphorylation in muscle." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540256.

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31

Zhao, Yingzi, and 趙瑩子. "Acute and chronic impact of pressure on vascular responsiveness." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/207185.

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Hypertension leads to vascular complications including endothelial dysfunction, heart failure and stroke. The purpose of the present studies was to investigate the chronic and acute impact of high pressure on vascular responsiveness. In Study I, isometric tension measurements demonstrated that contractions to phenylephrine, in the presence of indomethacin (inhibitor of cyclooxygenase), were smaller in aortae of spontaneously hypertensive rats (SHR) with, than in those without, endothelium, while they were comparable in such preparations of normotensive Wistar-Kyoto rat (WKY); the difference

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32

Hauck, James Spencer. "Mineralocorticoid Receptor Signaling in Acute and Chronic Muscle Injury." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1565089935933727.

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33

Bucciarelli-Ducci, Chiara. "Cardiovascular magnetic resonance of acute and chronic myocardial ischaemia." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/10112.

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BACKGROUND: Ischaemic heart disease is the leading cause of mortality and morbidity in the developed world. Cardiovascular magnetic resonance (CMR) is a non-invasive imaging modality providing in vivo myocardial tissue characterisation and quantification. We aimed to validate CMR in the field of interventional cardiology as a tool for guiding patient selection and management to the assessment of the results of interventions both in the acute and chronic settings. METHODS AND RESULTS: We investigated the impact of primary angioplasty delay on the presence and extent of myocardial salvage, micro

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34

Shires, Alice. "Brief mindfulness exposure interventions in acute and chronic pain." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/27781.

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Mindfulness-based interventions (MBIs) have been shown to be efficacious in the management of chronic pain, but some forms of MBIs are very intensive. This thesis aims to harness the benefits of mindfulness for people with pain by developing and testing a brief strategy, the mindfulness-based interoceptive exposure task (MIET), to help manage pain. The theoretical and conceptual basis of the MIET is described followed by a series of empirical studies testing the efficacy of the MIET. In the first study the MIET was administered to 15 consecutive patients with chronic pain. Results showed large

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35

Christiaansen, Allison Fae. "T cell regulation of acute and chronic viral infection." Diss., University of Iowa, 2016. https://ir.uiowa.edu/etd/6076.

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A balanced immune response is required to mediate clearance of a virus infection without immune-mediated disease. CD4 and CD8 T cells are capable of both exerting antiviral effector functions and regulating the immune response. The regulatory T cell (Treg) subset of CD4 T cells helps to modulate immune activation and inflammation. During respiratory syncytial virus (RSV) infection in mice, conventional CD4 T-cell-mediated cytokine production has been shown to contribute to immune-mediated pathology.

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36

Tadinada, Satya Murthy. "Cardiac effects of acute hyperinsulinemia and chronic fat feeding." Diss., University of Iowa, 2019. https://ir.uiowa.edu/etd/7034.

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Diabetic cardiomyopathy characterized by left ventricular hypertrophy predisposes diabetic and obese individuals to development of cardiac dysfunction and subsequently to heart failure. Whether hyperinsulinemia has an underlying role in development and or progression of diabetic heart disease is not well understood. We therefore studied the effects of acute hyperinsulinemia on cardiac function in euglycemic states. Acute hyperinsulinemia neither affected baseline nor inotropic response to β-adrenergic stimulation. Previous studies from our laboratory have indicated a potential role for GRK2, a

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37

Lipski, Marcin. "High-intensity interval eccentric cycling: Acute and chronic effects." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2018. https://ro.ecu.edu.au/theses/2104.

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Eccentric cycling training has been prescribed in continuous and low intensities protocols, based on concentric cycling parameters. While the lower metabolic demand of eccentric than concentric cycling is advantageous for clinical or ‘at-risk’ populations, it is a disadvantage for cardiovascular and pulmonary adaptations. High-intensity interval protocols may increase both, strength and endurance. Thus, this research project compared i) an incremental concentric and eccentric cycling test until exhaustion for the relationship between power output and physiological parameters <Study1>; ii) inte

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38

Ortemenka, Ye P. "The reasonability of using leukogramm’s indicies in the argumentation of antibioticotherapy for acute obstructive bronchitis in children." Thesis, БДМУ, 2021. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18413.

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39

Рашевська, Юлія Олександрівна, Олександр Іванович Сміян, Александр Иванович Смиян, et al. "Microbiota of the colon state in children of the first year of life with acute obstructive bronchitis." Thesis, Aluna Publishing, 2020. https://essuir.sumdu.edu.ua/handle/123456789/81170.

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Мета: Дослідити кількісний та якісний статус мікробіоценозу кишечника у дітей першого року життя з гострим обструктивним бронхітом (ГОБ). Клінічне дослідження проводилось за участю 27 дітей першого року життя з ГОБ. Контрольну групу складали 16 здорових дітей. Для визначення стану мікробіоценозу кишечника проводили мікробіологічні дослідження фекалій для визначення видового складу та рівня популяції мікрофлори. У більшості дітей першого року життя з ГОБ клінічні прояви порушень мікробіоценозу кишечника відзначались як диспептичний синдром. В гострий період виявлено кількість біфідо- та ла

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40

Sabapathy, Surendran, and n/a. "Acute and Chronic Adaptations To Intermittent and Continuous Exercise in Chronic Obstructive Pulmonary Disease Patients." Griffith University. School of Physiotherapy and Exercise Science, 2006. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20070115.170236.

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The primary aim of this thesis was to develop a better understanding of the physiology and perceptual responses associated with the performance of continuous (CE) and intermittent exercise (IE) in patients with moderate chronic obstructive pulmonary disease (COPD). A secondary aim was to examine factors that could potentially limit exercise tolerance in COPD patients, particularly in relation to the dynamics of the cardiovascular system and muscle metabolism. The results of the four studies conducted to achieve these aims are presented in this thesis. In Study 1, the physiological, metabolic a

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Sabapathy, Surendran. "Acute and Chronic Adaptations To Intermittent and Continuous Exercise in Chronic Obstructive Pulmonary Disease Patients." Thesis, Griffith University, 2006. http://hdl.handle.net/10072/366117.

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The primary aim of this thesis was to develop a better understanding of the physiology and perceptual responses associated with the performance of continuous (CE) and intermittent exercise (IE) in patients with moderate chronic obstructive pulmonary disease (COPD). A secondary aim was to examine factors that could potentially limit exercise tolerance in COPD patients, particularly in relation to the dynamics of the cardiovascular system and muscle metabolism. The results of the four studies conducted to achieve these aims are presented in this thesis. In Study 1, the physiological, metabolic a

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42

Khurana, Shruti. "Lung physiology & airway inflammation in COPD patients with persistent sputum production." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/lung-physiology-and-airway-inflammation-incopd-patients-with-persistent-sputum-production(b0f3374e-9a67-4ff9-a51e-d94eefa2f13c).html.

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Background: The clinical and pathological presentation of COPD is heterogeneous. ‘Chronic bronchitis’ is a phenotype of COPD, which is a clinical diagnosis of a productive cough of ≥ 3 months for ≥ 2 consecutive years. Chronic bronchitis is associated with worse lung function, frequent exacerbations, recurrent hospitalisations and premature death in patients with COPD. Chronic bronchitis sufferers can be further subphenotyped into those who produce sputum during exacerbation or during winter months only and those who are ‘persistent sputum producers,’ who experience mucous hypersecretion throu

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43

Carroll, Nadine. "The use of protriptyline or nocturnal mechanical ventilatory support for respiratory failure in chronic bronchitis and emphysema." Thesis, University of Liverpool, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235493.

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44

McNaughton, Lance. "Nitric oxide and matrix metalloproteinases as mediators of chronic and acute inflammatory disorders in humans, focus on chronic liver damage and acute lung injury." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0010/NQ59635.pdf.

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45

Pallarés, López víctor. "Role of bioactive food compounds in acute and chronic inflammation." Doctoral thesis, Universitat Rovira i Virgili, 2012. http://hdl.handle.net/10803/96658.

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En els últims anys, s’ha estudiat com els agents antiinflamatoris presents en els aliments poden modular la inflamació relacionada amb diverses malalties. Les procianidines presents en fruites i vegetals i els àcids grassos poliinsaturats (PUFAs) presents en peix i els olis derivats d’ells són compostos que tenen diferents propietats antiinflamatòries en front de diverses malalties com l’obesitat, la diabetis i malalties cardiovasculars. L’objectiu del nostre estudi va ser investigar diferents aspectes i mecanismes relacionats amb l’eficàcia d’un extracte de procianidines de pinyol de raïm (GS

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46

Fitch, Paul Michael. "SHH signalling in acute pulmonary cell injury and chronic fibrosis." Thesis, University of Edinburgh, 2005. http://hdl.handle.net/1842/28019.

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This thesis addresses the hypothesis that the sonic hedgehog (shh) signalling pathway is up regulated in response to cellular injury and that this signal acts as a potential pro-fibrogenic signal in pulmonary inflammation. <i>In vitro </i>studies utilised human (A549) and mouse (CMT) type II like epithelial cell lines in an analysis of epithelial response to injury. An immediate up regulation and release of soluble shh in response to hydrogen peroxide exposure was identified in mouse epithelium, utilising both RT-PCR and a novel shh ELISA developed here. Subsequent up-regulation and release of

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47

Stewart, Simon. "Optimising therapeutic efficacy in acute and chronic cardiac disease states /." Title page, contents and abstract only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09phs851.pdf.

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Melillo, Monica. "Application of carbon adsorbents for chronic and acute renal failure." Thesis, University of Brighton, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406815.

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Bauer, Moises Evandro. "Endocrine-immune interactions in major depression, acute and chronic stress." Thesis, University of Bristol, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266950.

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Tracy, Matthew. "Acute and Chronic Effects of Inhalants in Intracranial Self-stimulation." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4169.

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Abstract:

Inhalants are a loosely defined diverse group of volatile substances which people abuse. Despite widespread misuse of inhalants, there are limited preclinical methods available to study the reinforcement-like properties of inhalants. One procedure which has demonstrated substantial promise as a tool to investigate inhalant pharmacology is the intracranial self-stimulation (ICSS) procedure. ICSS utilizes pulses of electrical stimulation to the mesolimbic reward pathway to serve as a temporally defined and controlled operant reinforcer with a highly adjustable efficacy. The first aim of the proj

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