Relevant bibliographies by topics / Acute exacerbation

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Acute exacerbation'

Author: Grafiati
Published: 4 June 2021
Last updated: 9 March 2023

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Journal articles on the topic "Acute exacerbation"

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Voorham, Jaco, Massimo Corradi, Alberto Papi, Claus F. Vogelmeier, Dave Singh, Leonardo M. Fabbri, Marjan Kerkhof, Janwillem H. Kocks, Victoria Carter, and David Price. "Comparative effectiveness of triple therapy versus dual bronchodilation in COPD." ERJ Open Research 5, no. 3 (July 2019): 00106–2019. http://dx.doi.org/10.1183/23120541.00106-2019.

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This real-world study compared the effectiveness of triple therapy (TT; long-acting muscarinic antagonists (LAMAs)/long-acting inhaled β-agonists (LABAs)/inhaled corticosteroids (ICSs)) versus dual bronchodilation (DB; LAMAs/LABAs) among patients with frequently exacerbating COPD. A matched historical cohort study was conducted using United Kingdom primary care data. Patients with COPD aged ≥40 years with a history of smoking were included if they initiated TT or DB from no maintenance/LAMA therapy and had two or more exacerbations in the preceding year. The primary outcome was time to first COPD exacerbation. Secondary outcomes included time to treatment failure, first acute respiratory event, and first acute oral corticosteroid (OCS) course. Potential treatment effect modifiers were investigated. In 1647 matched patients, initiation of TT reduced exacerbation risk (adjusted hazard ratio (HR) 0.87, 95% CI 0.76–0.99), risk of acute respiratory event (HR 0.74, 95% CI 0.66–0.84) and treatment failure (HR 0.83, 95% CI 0.73–0.95) compared with DB. Risk reduction for acute respiratory events was greater for patients with higher rates of previous exacerbations. At baseline blood eosinophil counts (BECs) ≥ 0.35×109 cells·L−1, TT was associated with lower risk of OCS prescriptions than DB. This study provides real-life evidence of TT being more effective in reducing exacerbation risk than DB, which became more accentuated with increasing BEC and previous exacerbation rate.
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Lu, Fengfeng, Nengluan Xu, and Jianshi Zheng. "Association of β2-Agonist Receptor Gene Polymorphisms with Acute Exacerbations of COPD: A Prospective Observational Study." Emergency Medicine International 2022 (September 12, 2022): 1–5. http://dx.doi.org/10.1155/2022/2711489.

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Objective. To investigate the relationship between β2-agonist receptor gene polymorphisms and acute exacerbations of chronic obstructive pulmonary disease (COPD). Methods. Retrospective analysis of 99 patients in the respiratory and critical care unit of Fujian Provincial Hospital from 2018 to 2020. The clinical characteristics of different genotypes were compared, and the treatments of different genotypes and the analysis of factors associated with acute exacerbations of COPD were compared. Results. During the 12-month follow-up period, 53 patients developed acute exacerbations, with the 16Arg/Arg homozygous requiring significantly more antibiotics and hormones than the other two genotypes; when agonist receptor 16 gene polymorphism was associated with the risk of acute exacerbation, 16Arg/Gly patients had a 5.286-fold increased risk of acute exacerbation (OR = 6.286, 95% CI. 1.476–26.759, P = 0.013 ). 16Arg/Arg patients had a 5.060-fold increased risk of acute exacerbation (OR = 6.060, 95% confidence interval: 1.407–26.161, P = 0.016 ). Conclusion. Acute exacerbation of 16Arg/Arg COPD is very serious; 16Arg/Gly increases the risk of acute exacerbation in COPD patients; and provides help for future treatment and management options of the disease.
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Ruzanov, D. Yu, E. V. Voropaev, V. A. Vorobey, S. V. Mironova, O. V. Osipkina, L. N. Semenova, I. V. Buynevich, A. A. Zyatkov, N. N. Rubanik, and N. A. Bonda. "Etiological verification of infectious exacerbation of chronic obstructive lung disease using molecular genetics methods." Health and Ecology Issues, no. 2 (June 28, 2019): 94–102. http://dx.doi.org/10.51523/2708-6011.2019-16-2-18.

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Objective: To study the possibilities of the method of determining the 16S rRNA gene of bacteria in the determination of the bacterial spectrum of acute exacerbation of chronic obstructive pulmonary disease (COPD) using a protected material sampling Materials and Methods: 68 Hospitalized patients with acute exacerbation of COPD were prospectively evaluated. Molecular genetic determination of the 16S rRNA gene of bacteria and cultural microbiological techniques from sputum and a bronchial tree material obtained using a protected brush biopsy were used. Results: Bacterial agents were detected in 91,2 % of cases of acute exacerbation of COPD. Pseudomonas aeruginosa was detected in the biopsy material 1.8 times more often than with the use of routine methods. Patterns of COPD with frequent exacerbations, infectious exacerbations and Pseudomonas etiology of exacerbations were determined. Conclusion: Using the method of molecular-genetic determination of the 16S rRNA gene allows to verify the bacterial spectrum of acute exacerbation of COPD.
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Xiao, Wei, Long-yi Du, Bing Mao, Ti-wei Miao, and Juan-juan Fu. "Endotype-driven prediction of acute exacerbations in chronic obstructive pulmonary disease (EndAECOPD): protocol for a prospective cohort study." BMJ Open 9, no. 11 (November 2019): e034592. http://dx.doi.org/10.1136/bmjopen-2019-034592.

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IntroductionCurrent strategies for the prevention of acute exacerbations in chronic obstructive pulmonary disease (COPD) are primarily based on clinical measurements but fail to target the pathophysiological mechanisms, namely endotypes, of the disease. Studies identifying endotypes underlying exacerbation susceptibility and discovering specific biomarkers may lead to the development of targeted therapeutics but are lacking. This study aims to assess a broad spectrum of biomarkers at multiple biological levels (genetics, airway inflammation and respiratory microbiome) for their ability in predicting acute exacerbations of COPD, thus enables high-resolution disease endotyping and may lead to precision treatment of the disease.Methods and analysisIn this prospective cohort study, participants with stable COPD (n=600) will be recruited and assessed for demographics, symptom scores, spirometry, medication use and comorbidities at baseline. Blood will be obtained for genotyping variants in a panel of nine genes. Induced sputum will be collected for the profile of microbiota using 16S rRNA gene sequencing, quantification of bacterial load, inflammatory mediators assay and sputum cytometry. Participants will be followed up for their exacerbations till 12 months and reassessed for the clinical measurements as baseline. The primary outcomes are total number of exacerbations, severe exacerbations, moderate exacerbations and time to first exacerbation. The secondary outcomes are changes in lung function and symptom scores. The effect of biomarkers representing genetic variants, airway inflammation and respiratory microbiome on predicting the frequent exacerbator phenotype and exacerbation frequency will be analysed with multivariable modelling, and time to first exacerbation with a Cox regression model.Ethics and disseminationThe study has been approved by the Clinical Trial and Biomedical Ethics Committee of West China Hospital of Sichuan University (No. 2018–298). The results of the study will be published on peer-reviewed journals.Trial registration numberChiCTR1800019063.
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Müllerová, Hana, Jonathan Marshall, Enrico de Nigris, Precil Varghese, Nick Pooley, Nina Embleton, Clementine Nordon, and Zoe Marjenberg. "Association of COPD exacerbations and acute cardiovascular events: a systematic review and meta-analysis." Therapeutic Advances in Respiratory Disease 16 (January 2022): 175346662211136. http://dx.doi.org/10.1177/17534666221113647.

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Background: The majority of patients with chronic obstructive pulmonary disease (COPD) suffer from comorbid cardiovascular (CV) disease. Accumulating evidence suggests a temporal association between COPD exacerbations and acute CV events, possibly due to lung hyperinflation, increased hypoxemia and systemic inflammation. The aims of the study were to estimate the risk of (1) acute CV events [acute myocardial infarction (AMI), CV-related death] or stroke in the months following a COPD exacerbation and (2) COPD exacerbation in the months following an acute CV event. Methods: A systematic literature review of observational studies published since 2000 was conducted by searching literature databases (Medline and Embase). Studies were eligible if conducted in adults with COPD, exposed to either COPD exacerbation or acute CV events, with outcomes of acute CV events or COPD exacerbation reported. Studies were appraised for relevance, bias and quality. Meta-analyses, using random-effect models, were performed for each outcome of interest, thus providing a pooled relative risk (RR) and its 95% confidence interval. Results: Eight studies were identified, of which seven were used for the meta-analyses examining the risk of CV events 1–3 months after an exacerbation compared with none. For stroke (six studies), RR was 1.68 (95% CI = 1.19–2.38). For AMI (six studies), RR was 2.43 (95% CI = 1.40–4.20). No studies exploring risk of exacerbation following an acute CV event were identified. Conclusion: This meta-analysis identified a markedly increased risk of stroke or AMI within a relatively short period of time following a COPD exacerbation. Although the underlying mechanisms are not fully elucidated, patients with COPD should be monitored for risk of CV outcomes after exacerbations. In addition, preventing exacerbations may decrease the risk of subsequent acute CV events. Registration: The study protocol was published via PROSPERO: International Prospective Register of Systematic Reviews (#CRD42020211055).
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Matsuse, Hiroto, Tomoko Tsuchida, Susumu Fukahori, Tetsuya Kawano, Shinya Tomari, Nobuko Matsuo, Tomoya Nishino, Chizu Fukushima, and Shigeru Kohno. "Retrospective Cohort Study of Leukotriene Receptor Antagonist Therapy for Preventing Upper Respiratory Infection-Induced Acute Asthma Exacerbations." Allergy & Rhinology 4, no. 3 (January 2013): ar.2013.4.0062. http://dx.doi.org/10.2500/ar.2013.4.0062.

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Upper respiratory tract infections (URIs) represent the most frequent cause of acute asthma exacerbations. It has yet to be determined whether leukotriene receptor antagonist (LTRA) treatment prevents URI-induced acute asthma exacerbations in adults. The objective of the present study was to evaluate the preventive effects of LTRA treatment on URI-induced acute asthma exacerbations. The incidences of URI alone, acute asthma exacerbation without URI, and URI-induced acute asthma exacerbation were determined retrospectively by analyzing diary and medical records of 321 adult asthmatic patients (mean age, 56.3 ± 17.2 years; male/female ratio, 117:204) over 1 year. Results were compared between patients who had been taking an LTRA (n = 137) and those who had never taken any LTRA (n = 184) during the study periods. Significantly fewer URIs alone and acute asthma exacerbations without URI occurred in patients with than in those without prophylactic daily use of LTRA. LTRA treatment significantly reduced the durations of URIs alone and of total acute asthma exacerbations, as well as the incidence of mild exacerbations of asthma. In contrast, in patients with URI-induced acute asthma exacerbations, LTRA treatment failed to significantly reduce the interval between URI onset and acute asthma exacerbation, as well as the duration and severity of both URIs and acute asthma exacerbations. Use of an LTRA for adult asthmatic patients appears to reduce the incidences of URIs alone and acute asthma exacerbations without URI, but it failed to prevent URI-induced acute asthma exacerbations once a URI occurred.
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Rong, Yiran, John P. Bentley, Gerald McGwin, Yi Yang, Benjamin F. Banahan, Sara L. Noble, Terri Kirby, and Sujith Ramachandran. "Association Between Transient Opioid Use and Short-Term Respiratory Exacerbation Among Adults With Chronic Obstructive Pulmonary Disease: A Case-Crossover Study." American Journal of Epidemiology 188, no. 11 (August 30, 2019): 1970–76. http://dx.doi.org/10.1093/aje/kwz169.

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Abstract The association of historical opioid use with health care use and death among patients with chronic obstructive pulmonary disease (COPD) has been tested. Using Mississippi Medicaid data, we examined the association of transient or short-term opioid use and acute respiratory exacerbations among adults with COPD. We used a case-crossover design and 2013–2017 Mississippi Medicaid administrative claims data. A total of 1,972 qualifying exacerbation events occurred in 1,354 beneficiaries. The frequency and dose of opioid exposure in the 7 days before the exacerbation were examined and compared with the opioid exposure in 10 control windows, each 7 days long, before the exacerbation. Adjusted odds ratios were estimated using conditional logistic regression models to estimate the risk of opioid use on exacerbations after accounting for use of bronchodilators, corticosteroids, benzodiazepines, and β-blockers. Overall, opioid exposure in the 7 days before an exacerbation was significantly associated with acute respiratory exacerbation (odds ratio = 1.81; 95% confidence interval: 1.60, 2.05). Each 25-mg increase in morphine equivalent daily dose was associated with an 11.2% increase in the odds of an acute respiratory exacerbation (odds ratio = 1.11; 95% confidence interval: 1.04, 1.20). Transient use of opioids was significantly associated with acute respiratory exacerbation of COPD.
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Li, A. K., M. Barton, J. A. Delport, and D. Ashok. "Edwardsiella tardaInfection Triggering Acute Relapse in Pediatric Crohn’s Disease." Case Reports in Infectious Diseases 2019 (March 20, 2019): 1–3. http://dx.doi.org/10.1155/2019/2094372.

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Crohn’s disease exacerbations can often be associated with bacterial infections causing gastroenteritis. We report a child who experienced exacerbation of his Crohn’s disease associated with a positive stool culture forEdwardsiella tarda (E. tarda). Endoscopy showed features of moderate inflammation similar to exacerbation of Crohn’s disease. The patient was treated simultaneously with intravenous steroids and antibiotics, and his symptoms resolved. This case report highlights the importance of clinicians being able to promptly recognize and treat concurrent bacterial infections in Crohn’s disease exacerbations.
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Collard, Harold R., Luca Richeldi, Dong Soon Kim, Hiroyuki Taniguchi, Inga Tschoepe, Maurizio Luisetti, Jesse Roman, et al. "Acute exacerbations in the INPULSIS trials of nintedanib in idiopathic pulmonary fibrosis." European Respiratory Journal 49, no. 5 (May 2017): 1601339. http://dx.doi.org/10.1183/13993003.01339-2016.

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Time to first investigator-reported acute exacerbation was a key secondary end-point in the INPULSIS trials of nintedanib in patients with idiopathic pulmonary fibrosis (IPF).We used the INPULSIS trial data to investigate risk factors for acute exacerbation of IPF and to explore the impact of nintedanib on risk and outcome of investigator-reported and adjudicated confirmed/suspected acute exacerbations. Mortality following these events and events adjudicated as not acute exacerbations was analysed using the log rank test.Risk of acute exacerbations was most strongly associated with the following variables: baseline forced vital capacity (higher risk with lower value), baseline supplemental oxygen (higher risk with use), baseline antacid medication (higher risk with use), treatment (higher risk with placebo), and for confirmed/suspected acute exacerbations, cigarette smoking. Mortality was similar following investigator-reported and adjudicated confirmed/suspected acute exacerbations. Nintedanib had no significant effect on risk of mortality post-exacerbation.Investigator-reported acute exacerbations of IPF are associated with similar risk factors and outcomes as adjudicated confirmed/suspected acute exacerbations.
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Park, Sang Hyun, Chang Min Kang, Dae Seong Kim, Han Ho Kim, and Young Yoo. "Cytokine Imbalance in a 15-year-old Boy with Pandemic Influenza an Infection Requiring Extracorporeal Membrane Oxygenation." Hong Kong Journal of Paediatrics Research 4, no. 3 (December 30, 2021): 38–41. http://dx.doi.org/10.37515/pediatric.5887.4302.

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Acute severe asthma is an acute episode of intractable asthma that is poorly responsive to standard management. Acute respiratory failure or acute respiratory distress syndrome (ARDS) requiring ventilator support may be life-threatening. Although respiratory viral infections are responsible for most asthma exacerbations, the seasonal influenza virus has not been considered a risk factor. However, the 2009 H1N1 influenza A pandemic strain (pH1N1), which has resulted in numerous hospitalizations and mortalities worldwide, has been reported to be closely related to asthma exacerbation. Thus, with over 300 million people suffering from asthma worldwide, further studies are needed to protect this vulnerable population that is highly susceptible to pH1N1 infection. Dysregulation of Th1/Th2 cytokines may be involved in asthma exacerbation. We report the case of a paediatric patient with acute respiratory failure due to asthma exacerbation triggered by pH1N1 infection. The patient exhibited Th2 polarization in the acute phase of exacerbation and recovered from ARDS through timely ventilator support and subsequent extracorporeal membrane oxygenation. Further investigation regarding the mechanism of immune response in asthma exacerbations associated with pH1N1 infection may elucidate the optimal treatment for asthma.
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Dissertations / Theses on the topic "Acute exacerbation"

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Chen, Roy Yu-Wei. "Biomarkers for acute exacerbation of chronic obstructive pulmonary disease." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/57759.

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Rationale: There are currently no generally accepted and validated blood tests available for diagnosing acute exacerbations of chronic obstructive pulmonary disease (AECOPD). There is an urgent need of biomarkers that can guide therapeutic management in AECOPD. Based on literature review, systemic inflammation and mild cardiac dysfunction are often associated with AECOPD. We hypothesized that certain protein markers can indeed be useful in tracking and diagnosing AECOPD progression. Methods: The study cohort consisted of 368 patients recruited in the chronic obstructive pulmonary disease (COPD) Rapid Transition Program who were hospitalized with a primary diagnosis of AECOPD, and 76 stable COPD patients who served as controls. We first determined the relationship of AECOPD of C-reactive protein (CRP) and the N-terminal of the prohormone brain natriuretic peptide (NT-proBNP). We then performed a discriminatory analysis using receiver-operating characteristics (ROC) curve in a logistic regression model. We compared the area under the curve (AUC) of 4 different combinations of CRP and NT-proBNP models. Lastly, we examined several potential biomarkers that were implicated in AECOPD. Results: The demographic data of the cohort and the controls were well matched, with an average age of 68 versus 65 years old, 64% versus 77% male, and a forced expiratory volume in 1 second (FEV1) % predicted of 52% versus 58%. The CRP and NT-proBNP levels at exacerbation onset were found to be the highest and progressively decreased over time. Of the 4 models of ROC curves, the leave-one-out cross-validated model including both CRP and NT-proBNP had an AUC of 0.80. This model replicated well in an external LEUKO dataset. On the ii other hand, D-Dimer, pulmonary and activation-regulated chemokine (PARC) and troponin I, showed minimal or no temporal changes during hospitalization and were no different than those with stable COPD. Conclusions: In summary, this thesis demonstrated that biomarkers such as CRP and NT-proBNP are significantly elevated during AECOPD and decreased with recovery. Secondly, a combination of CRP and NT-proBNP could discriminate patients who were hospitalized for their AECOPD from stable patients. Together, these two biomarkers show promise in diagnosing and tracking AECOPD.
Medicine, Faculty of
Medicine, Department of
Experimental Medicine, Division of
Graduate
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Jenkins, Bradlee A., and L. Lee Glenn. "Variability of FEV and Criterion for Acute Pulmonary Exacerbation." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etsu-works/7465.

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Excerpt: Morgan et al. (1) concluded that cystic fibrosis (CF) in children and adolescents with a high baseline forced expiratory volume (FEV1) were less likely to have a therapeutic intervention or slower rate of FEV1 decline after a single acute decline in FEV1 of 10%. This conclusion is not well supported due to the arbitrary criteria used for defining a pulmonary exacerbation, as explained below.
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Chang, Catherina Li-Lin. "Hospitalisations for acute exacerbation of COPD: patterns of disease, risk prediction and treatment." Thesis, University of Auckland, 2011. http://hdl.handle.net/2292/7118.

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Flaherty, Helen M. "Informal Caregivers’ Experience During Acute Exacerbation of COPD in Older Adults: A Dissertation." eScholarship@UMMS, 2017. https://escholarship.umassmed.edu/gsn_diss/51.

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Chronic obstructive pulmonary disease (COPD) has been recognized as a leading cause of mortality in older adults involving acute exacerbations as life-threatening events that lead to frequent hospitalization for care. Informal caregivers have been essential to helping older adults with COPD during an acute exacerbation of chronic obstructive pulmonary disease (AECOPD). A lack of empirical knowledge exists regarding the experience of informal caregivers of older adults with AECOPD in situation awareness for recognizing, understanding, and responding to an AECOPD in an emergent situation. This qualitative descriptive study explored situation awareness and its components of perception, comprehension and projection of next steps, including the caregiver’s confidence level during the AECOPD event. Fifteen informal caregivers, ages 31-77 years (mean age 48), who provided care for older adults with COPD were interviewed from an underserved community health center. The overarching theme derived from this study was something was wrong and something needed to be done. Subthemes emerged as a heightened sense of awareness, caregiver tipping point, planning next steps, caregiver confidence, and caregiver commitment. This study utilized situation awareness theory as a relevant guiding framework in exploring the experience of lay informal caregivers caring for older adults with AECOPD events. Study findings provided a description of the complex processes involved, including confidence level, for informal caregiver’s in situation awareness to recognize and respond to an AECOPD event in the older adult. Future targeted interventions need to address strategies to enhance individualized care for older adults with AECOPD events for managing care at home.
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Reavell, Colleen Frances. "Resolution of muscle wasting during an acute exacerbation of chronic obstructive pulmonary disease (COPD)." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0031/MQ64435.pdf.

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Bailey, Patricia Hill. "Patients', family caregivers', and nurses' stories of acute exacerbation events of Chronic Obstructive Pulmonary Disease." Thesis, University of Edinburgh, 1998. http://hdl.handle.net/1842/21379.

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Chin, Elizabeth D. "Symptom Experience and Treatment Delay during Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsn_diss/30.

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Chronic obstructive pulmonary disease (COPD) is a major health problem in the United States. Acute exacerbations of COPD are primarily responsible for the physical, psychological and economic burden of this disease. Early identification and treatment of exacerbations is important to improve patient and healthcare outcomes. Little is known about how patients with COPD recognize an impending exacerbation and subsequently decide to seek treatment. The purpose of this qualitative descriptive study was to explore and describe symptom recognition and treatment delay in individuals experiencing an acute exacerbation of chronic obstructive pulmonary disease (COPD). Leventhal’s Common Sense Model of illness representation undergirded this study. Using semi-structured interviews, adults hospitalized with an acute exacerbation of COPD were asked to describe their symptom experience and self care behaviors, including treatment seeking, in the days to weeks prior to hospitalization. Data analysis revealed one main theme: Recognizing, responding and reacting to change, and six subthemes: Something’s coming, Here we go again, Seeking urgent treatment, Riding it out, Not in charge anymore and My last day that richly described the COPD exacerbation experience. The study revealed that patients experience an illness prodrome prior to exacerbation and have a recurrent exacerbation symptom pattern that was self-recognized. Treatment seeking was most influenced by the speed and acuity of exacerbation onset, severity of breathlessness, fears of death, nature of patient-provider relationship and the perception of stigmatization during prior healthcare encounters. These findings are important for the development of interventions to improve patient recognition and management of COPD exacerbations in the future.
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Mirza, Mohd Tahir Beg Fatim Tahirah. "Optimising Assessment and Rehabilitation in People Hospitalised with an Acute Exacerbation of Chronic Obstructive Pulmonary Disease." Thesis, Curtin University, 2016. http://hdl.handle.net/20.500.11937/76705.

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This research; (i) evaluated the measurement properties of the two-minute walk test (2MWT), including the effect of test repetition, coefficient of repeatability and validity, and compared the cardiorespiratory responses and symptoms reported during the 2MWT and the six-minute walk test, (ii) developed regression equations to estimate the two-minute walk distance and (iii) evaluated the effectiveness of an exercise program in people hospitalised with an AECOPD on exercise capacity, muscle force, functional performance and physical activity.
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Knaut, Caroline. "Avaliação dos efeitos do programa de exercício físico aeróbico de curta duração em pacientes hospitalizados por exacerbação aguda da dpoc nos diferentes desfechos clínicos." Botucatu, 2019. http://hdl.handle.net/11449/181469.

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Orientador: Suzana Erico Tanni Minamoto
Resumo: Introdução: A exacerbação aguda é uma importante causa de perda de função em pacientes com doença pulmonar obstrutiva crônica (DPOC). Afeta negativamente a qualidade de vida, a função pulmonar, a fraqueza muscular, o uso de recursos de saúde e a sobrevivência. Acredita-se que o exercício físico realizado durante a exacerbação pode melhorar a qualidade de vida e a capacidade física do paciente sem aumento do processo inflamatório. Objetivo: Avaliar a influência do exercício físico aeróbico de curta duração durante a internação em marcadores inflamatórios, qualidade de vida e capacidade física, além de re-hospitalização e taxas de mortalidade seis meses após a alta hospitalar em pacientes com DPOC exacerbada. Pacientes e Métodos: 26 pacientes foram avaliados 24 horas após a hospitalização por características demográficas, história de tabagismo, índice de Charlson, qualidade de vida, marcadores inflamatórios sistêmicos e composição corporal. Após 48 horas de internação, todos os pacientes realizaram o teste de caminhada de 6 minutos e um novo teste de espirometria, sendo calculado o índice BODE. Após 72 horas de internação, os pacientes do grupo de intervenção foram submetidos a exercícios aeróbicos em esteira por 15 minutos, duas vezes ao dia. Por fim, um mês após a alta hospitalar, todos os pacientes foram reavaliados segundo a qualidade de vida, marcadores inflamatórios sistêmicos, composição corporal, espirometria, teste de caminhada de 6 minutos e índice BODE. Resultados: O... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Introduction: Acute exacerbation is an important cause of loss of function in patients suffering from chronic obstructive pulmonary disease (COPD). It negatively affects the quality of life, lung function, muscle weakness, use of health resources and survival. It is believed that the physical exercise performed during the exacerbation can improve the quality of life and the physical capacity of the patient without an increase in the inflammatory process. Objective: To evaluate the influence of short-term aerobic physical exercise during hospitalization on inflammatory markers, quality of life and physical capacity, as well re-hospitalization and mortality rates six months after hospital discharge in patients with exacerbated COPD. Patients and Methods: 26 patients were evaluated 24 hours after hospitalization for demographic characteristics, smoking history, Charlson index, quality of life, systemic inflammatory markers and body composition. After 48 hours hospitalization, all patients performed a 6-minute walk test and a new spirometry test, and BODE index was calculated. After 72 hours of hospitalization, patients in the intervention group underwent aerobic exercise on a treadmill for 15 minutes twice daily. Finally, a month after hospital discharge, all patients were re-evaluated according to quality of life, systemic inflammatory markers, body composition, spirometry, 6-minute walk test and BODE index. Results: Patients in the intervention and control group did not differ... (Complete abstract click electronic access below)
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Gau, Jen-Tzer, Utkarsh H. Acharya, M. Salman Khan, and Tzu-Cheg Kao. "Risk factors associated with lower defecation frequency in hospitalized older adults: a case control study." BioMed Central Ltd, 2015. http://hdl.handle.net/10150/610289.

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BACKGROUND: Constipation is highly prevalent in older adults and may be associated with greater frequency of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). We investigated the prevalence of lower defecation frequency (DF) and risk factors (including AECOPD) associated with lower DF among hospitalized elderly patients. METHODS: We conducted a retrospective case-control study in a community hospital of Southeast Ohio. Adults aged 65 years or older admitted during 2004 and 2006 were reviewed (N = 1288). Patients were excluded (N = 212) if their length of stay was less than 3 days, discharge diagnosis of Clostridium difficile-associated diarrhea, death or ventilator- dependent respiratory failure during hospitalization. Lower DF was defined as either an average DF of 0.33 or less per day or no defecation in the first three days of hospitalization; cases (N = 406) and controls (N = 670) were included for the final analysis. RESULTS: Approximately 38% had lower DF in this patient population. Fecal soiling/smearing of at least two episodes was documented in 7% of the patients. With the adjustment of confounders, AECOPD (adjusted odds ratio [AOR] =1.47, 95% confidence interval [CI] =1.01-2.13) and muscle relaxant use (AOR =2.94; 95% CI =1.29-6.69) were significantly associated with lower DF. Supplementation of potassium and antibiotic use prior to hospitalization was associated with lower risk of lower DF. CONCLUSIONS: Approximately 38% of hospitalized older adults had lower DF. AECOPD and use of muscle relaxant were significantly associated with lower DF; while supplementation of potassium and antibiotic use were protective for lower DF risk after adjusting for other variables.
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Books on the topic "Acute exacerbation"

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Acute exacerbation of respiratory diseases. New Delhi: Jaypee Brothers Medical Publishers, 2012.

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Ning, Qin, ed. Acute Exacerbation of Chronic Hepatitis B. Dordrecht: Springer Netherlands, 2019. http://dx.doi.org/10.1007/978-94-024-1603-9.

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Ning, Qin, ed. Acute Exacerbation of Chronic Hepatitis B. Dordrecht: Springer Netherlands, 2019. http://dx.doi.org/10.1007/978-94-024-1606-0.

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Cazzola, Mario. Acute exacerbations in COPD. Oxford: Clinical Pub., 2009.

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M, Siafakas N., Anthonisen N. R, and Georgopoulos Dimitris, eds. Acute exacerbations of chronic obstructive pulmonary disease. New York: M. Dekker, 2004.

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Lehmann, Harold P. Practice parameter: The treatment of acute exacerbations of asthma in children : technical report. Elk Grove Village, IL: The Academy, 1994.

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Sahn Steven, A. Clinical Focus Series: Acute Exacerbation of Respiratory Diseases. Jaypee Brothers Medical Publishers (P) Ltd., 2012. http://dx.doi.org/10.5005/jp/books/11683.

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Sahn, Steven A. Clinical Focus Series: Acute Exacerbation of Respiratory Diseases. Jaypee Brothers Medical Publishers, 2012.

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Ning, Qin. Acute Exacerbation of Chronic Hepatitis B: Volume 2. Diagnosis and Management. Springer, 2019.

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Rahimi, Kazem. Acute heart failure. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0091.

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Heart failure is a clinical syndrome characterized by an inadequate cardiac output for the needs of the body in the absence of low filling pressures, and reflects abnormal cardiac structure or function. Although various definitions for acute heart failure (AHF) exist, here AHF is defined as new-onset heart failure or an acute exacerbation of chronic heart failure, requiring urgent therapy. Patients with AHF typically have clinical features of organ hypoperfusion, with or without pulmonary and peripheral oedema.
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Book chapters on the topic "Acute exacerbation"

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Ishii, Yoshiki. "Acute Exacerbation of IPF." In Idiopathic Pulmonary Fibrosis, 27–42. Tokyo: Springer Japan, 2016. http://dx.doi.org/10.1007/978-4-431-55582-7_3.

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Lief, Lindsay, and Jakob McSparron. "Acute Exacerbation of COPD." In Evidence-Based Critical Care, 169–73. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-26710-0_22.

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Sibley, William A. "Treatment for an Acute Exacerbation." In Therapeutic Claims in Multiple Sclerosis, 31–45. London: Macmillan Education UK, 1988. http://dx.doi.org/10.1007/978-1-349-10872-5_3.

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Panselinas, Efstratios, and Marc A. Judson. "Acute Pulmonary Exacerbation of Sarcoidosis." In Pulmonary Sarcoidosis, 65–78. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-8927-6_4.

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Lee, Joyce S., and Harold R. Collard. "Acute Exacerbation of Idiopathic Pulmonary Fibrosis." In Idiopathic Pulmonary Fibrosis, 349–62. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-682-5_17.

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Lee, Joyce S., and Harold R. Collard. "Acute Exacerbation of Idiopathic Pulmonary Fibrosis." In Respiratory Medicine, 401–17. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-99975-3_17.

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Peng, Liang, Zhi-Liang Gao, Yu-Ming Wang, Deng-Ming He, Jing-Ming Zhao, Xue-Fan Bai, and Xiao-Jing Wang. "Clinical Manifestations and Laboratory Tests of AECHB and Severe Hepatitis (Liver Failure)." In Acute Exacerbation of Chronic Hepatitis B, 1–89. Dordrecht: Springer Netherlands, 2019. http://dx.doi.org/10.1007/978-94-024-1603-9_1.

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Song, Jian-Xin, Lin Zhu, Chuan-Long Zhu, Jin-Hua Hu, Zi-Jian Sun, Xiang Xu, Min-You Xin, et al. "Main Complications of AECHB and Severe Hepatitis B (Liver Failure)." In Acute Exacerbation of Chronic Hepatitis B, 91–226. Dordrecht: Springer Netherlands, 2019. http://dx.doi.org/10.1007/978-94-024-1603-9_2.

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Chen, Zhi, Qin Ning, and Guang Chen. "Early Prognostic Predictive System of AECHB and the Diagnosis of Severe Hepatitis B (Liver Failure)." In Acute Exacerbation of Chronic Hepatitis B, 227–71. Dordrecht: Springer Netherlands, 2019. http://dx.doi.org/10.1007/978-94-024-1603-9_3.

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Wang, Yu-Ming, Ke Li, Xiao-Guang Dou, Han Bai, Xi-Ping Zhao, Xiong Ma, Lan-Juan Li, Zhi-Shui Chen, and Yuan-Cheng Huang. "Treatment of AECHB and Severe Hepatitis (Liver Failure)." In Acute Exacerbation of Chronic Hepatitis B, 273–370. Dordrecht: Springer Netherlands, 2019. http://dx.doi.org/10.1007/978-94-024-1603-9_4.

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Conference papers on the topic "Acute exacerbation"

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Shpagina, L. A., E. B. Logashenko, and O. S. Kotova. "ACUTE EXACERBATIONS OF OCCUPATIONAL CHRONIC OBSTRUCTIVE PULMONARY DISEASE DUE TO INDUSTRIAL AEROSOLS CONTAINING." In The 16th «OCCUPATION and HEALTH» Russian National Congress with International Participation (OHRNC-2021). FSBSI “IRIOH”, 2021. http://dx.doi.org/10.31089/978-5-6042929-2-1-2021-1-593-597.

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Abstract. Phenotypes of exacerbations of occupational chronic obstructive pulmonary disease (COPD) due to aerosols containing nanoparticles is not studied enough. The objective was to establish rate, severity, cellular type of inflammation, clinical features of acute exacerbations of occupational COPD due to industrial aerosols containing nanoparticles exposure. Materials and methods. A prospective observational study of 50 subjects with occupational COPD (of which 26 due to aerosols, containing metal nanoparticles and 24 due to aerosols containing silica nanoparticles) and of 50 subjects with COPD due to tobacco smoke performed. Follow up period was 26 (24; 30) months. Groups were matched by age, gender, COPD duration. Groups of occupational COPD has the same smoking status. Nanoparticles and dust concentrations at workplaces air were measured by inductively coupled plasma atomic emission spectrometry and by scanning electron microscopy. COPD exacerbations rate and severity, cellular type of inflammation during exacerbations were investigated. Relationships were assessed by Cox proportional-hazards regression. Results. Occupational COPD due to aerosols containing metal nanoparticles exposure was characterized by high exacerbation rate. In comparison to occupational COPD due to aerosols containing silica nanoparticles exposure the hazard ratio (HR) was 4,59, 95% CI 1,35–15,63, in relation to COPD in tobacco smokers HR was 3,35, 95% CI1,22 – 9,21. The risk of exacerbations requiring hospitalization also was higher in this group, HR 4,35, 95% CI 1,10-12,3 and HR 3,90, 95% CI 1,33–11,42, respectively. In occupational COPD due to aerosols containing silica nanoparticles the exacerbation rate was the least. Metal nanoparticles mass concentration at the workplace air was associated with COPD exacerbations HR 1,031, 95% CI 1,012–1,11, exacerbations requiring hospitalization HR 1,028, 95% CI 1,010–1,092 and with eosinophilic inflammation during COPD exacerbation ОР 0,015, 95% CI 0,002 – 0,036. Silica nanoparticles mass concentration was associated with COPD exacerbations HR 0,025, 95% CI 0,003–0,094, exacerbations requiring hospitalization HR 0,021, 95% CI 0,009–0,105 and with neutrophilic inflammation during COPD exacerbation HR 1,019, 95% CI 1,008–1,057. Exacerbations of occupational COPD due to aerosols containing nanoparticles exposure had higher rate of respiratory support and excess length of hospital stay. Conclusion. Occupational COPD exacerbations are associated with chemical composition and mass concentration of nanoparticles in industrial aerosols
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Tine, Mariaenrica, Graziella Turato, Kim Lokar Oliani, Erica Bazzan, Umberto Semenzato, Davide Biondini, Matteo Bonato, Marina Saetta, and Manuel G. Cosio. "Acute exacerbation of COPD in Emergency Room: just COPD exacerbations?" In ERS International Congress 2019 abstracts. European Respiratory Society, 2019. http://dx.doi.org/10.1183/13993003.congress-2019.pa5220.

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Yoshida, Masahiro, Tomohisa Baba, Hideya Kitamura, Kouji Okudera, Tamiko Takemura, and Takashi Ogura. "Acute Exacerbation Of Idiopathic Pulmonary Fibrosis." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a5816.

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ALHAMED ALDUIHI, FATIMA. "ECG Abnormalities in Acute Exacerbation of Bronchiectasis." In ERS International Congress 2020 abstracts. European Respiratory Society, 2020. http://dx.doi.org/10.1183/13993003.congress-2020.2686.

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Ben Saad, Ahmed, Rania Kaddoussi, Asma Migaou, Nesrine Fahem, Samah Joobeur, Saousen Cheikh Mhamed, and Naceur Rouatbi. "Predictive factors of bronchiectasis acute exacerbation severity." In ERS International Congress 2021 abstracts. European Respiratory Society, 2021. http://dx.doi.org/10.1183/13993003.congress-2021.pa2077.

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Cushen, Breda, Garrett Greene, Elaine Mac Hale, Lorraine Tompkins, Imran Sulaiman, Fiona Boland, Emer Kelly, and Richard W. Costello. "Clinical and exacerbation characteristics may predict treatment response in acute exacerbations of COPD." In ERS International Congress 2018 abstracts. European Respiratory Society, 2018. http://dx.doi.org/10.1183/13993003.congress-2018.pa4094.

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Sadatsafavi, M., A. Adibi, T. Y. Lee, D. D. Sin, and A. Safari. "Recalibration and External Validation of Acute COPD Exacerbation Predictor (ACCEPT): Improving the Prediction of Acute Exacerbations of COPD." In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1129.

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Lyngby Kjærgaard, Jakob, Carsten Juhl, and Torgny Wilcke. "Early pulmonary rehabilitation after acute exacerbation of COPD." In ERS International Congress 2017 abstracts. European Respiratory Society, 2017. http://dx.doi.org/10.1183/1393003.congress-2017.pa761.

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Kjaergaard, Jakob Lyngby, Carsten B. Juhl, Mette Rosenberg, Hanne Rohde, Henny Riber, Linda Poulsen, and Torgny Wilcke. "Early pulmonary rehabilitation after acute exacerbation of COPD." In ERS International Congress 2018 abstracts. European Respiratory Society, 2018. http://dx.doi.org/10.1183/13993003.congress-2018.oa1618.

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Wu, C. P., A. Nazha, P. Bazeley, and J. G. Zein. "Novel Machine Learning to Predict Asthma Acute Exacerbation." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a1009.

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Reports on the topic "Acute exacerbation"

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du, xinying, xinying du, xianjun fu, kuo xu, and kejian li. Meta analysis on the treatment of acute exacerbation of chronic obstructive pulmonary disease with lung dispersing therapy. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, November 2022. http://dx.doi.org/10.37766/inplasy2022.11.0094.

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Ji, Zile, Xuanlin Li, Siyuan Lei, and Yang Xie. A pooling analysis of the risk prediction models for mortality in acute exacerbation of chronic obstructive pulmonary disease. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, April 2022. http://dx.doi.org/10.37766/inplasy2022.4.0151.

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Ji, Zile, Xuanlin Li, Siyuan Lei, and Yang Xie. A pooling analysis of the risk prediction models for mortality in acute exacerbation of chronic obstructive pulmonary disease. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, April 2022. http://dx.doi.org/10.37766/inplasy2022.4.0151.

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Gao, Ying, Shuang Wang, Kai Yin, and Yue Yuan. Efficacy and safety of Chuankezhi injection for treating acute exacerbation of chronic bronchitis: a protocol for systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, March 2022. http://dx.doi.org/10.37766/inplasy2022.3.0036.

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Kuroda, Hiroaki. Presurgical heterogeneity of lung 18FDG-PET uptake predicts acute exacerbation of interstitial lung disease following pulmonary resection in patients with smoke exposures. Science Repository OU, July 2019. http://dx.doi.org/10.31487/j.jso.2019.02.08.

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LEI, XING, and HONGMIN GUO. The effects of Su-Zi-Jiang-Qi decoction (SZJQ) in acute exacerbation of chronic obstructive pulmonary disease: a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, June 2021. http://dx.doi.org/10.37766/inplasy2021.6.0115.

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Chen, Dan, Jian Sun, and Ya-nan Chu. The diagnostic value of serum amyloid A in patients with acute exacerbation of chronic obstructive pulmonary disease: a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, April 2022. http://dx.doi.org/10.37766/inplasy2022.4.0143.

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Xing, Lei, Hongmin Guo, and Zhiqian Wang. Efficacy and safety of Suzi Jiangqi Decoction in patients with acute exacerbation of chronic obstructive pulmonary disease A protocol for systematic review and meta analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, August 2021. http://dx.doi.org/10.37766/inplasy2021.8.0035.

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Background: Chronic obstructive pulmonary disease (COPD) is characterized by chronic respiratory symptoms. The respiratory symptoms of patients with acute exacerbation of COPD (AECOPD) worsen rapidly. At present, traditional western medicine treatment can not effectively alleviate the symptoms and attack frequency of patients. Suzi Jiangqi decoction(SZJQ) has a good clinical effect in the treatment of AECOPD. Due to the lack of evidence-based medicine, it can not provide an effective systematic evaluation for the treatment of AECOPD with Suzi Jiangqi decoction. Therefore, it is necessary to provide high-quality evidence evaluation for the clinical efficacy and safety of Suzi Jiangqi Decoction in the treatment of AECOPD. Methods: Two researchers independently retrieved randomized controlled trial (RCT) and quasi-RCTs of SZJQ in the treatment of AECOPD from databases including PubMed, Web of science, the Cochrane Library, CBM, CNKI, Sinomed, VIP and WanFang.The included studies were evaluated for quality according to the RCT quality assessment method provided by Cochrane Reviewer's Handbook 5.3.Review Manager 5.3 software provided by the Cochrane collaboration was used for meta-analysis. Results: This study will provide systematic review on the efficacy and safety of SZJQ as adjuvant therapy in patients with AECOPD by rigorous quality assessment and reasonable data synthesis. Conclusions: This systematic review will provide the good evidence currently on SZJQ as adjuvant therapy in patients with AECOPD.
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Hong, Zheng, Ying Liu, HanYu Fang, Hongchun Zhang, and Bang Yu. Effectiveness and safety of Qingjin Huatan Capsule for acute exacerbation of Chronic Bronchitis or Chronic Obstructive Pulmonary Disease in adults: a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, September 2022. http://dx.doi.org/10.37766/inplasy2022.9.0075.

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Teng, Wenzhe, Hu Chen, Siyao Shi, Yin Wang, and Kangyao Cheng. Effect of bilevel continuous positive airway pressure for patients with type II respiratory failure due to acute exacerbation of COPD: A protocol for systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, November 2020. http://dx.doi.org/10.37766/inplasy2020.11.0003.

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