Relevant bibliographies by topics / Acute knee injury

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Acute knee injury'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Acute knee injury"

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Eranki, Vivek, Collie Begg, and Brian Wallace. "Outcomes of Operatively Treated Acute Knee Dislocations." Open Orthopaedics Journal 4, no. 1 (January 19, 2010): 22–30. http://dx.doi.org/10.2174/1874325001004010022.

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Knee dislocation is a complex and rare injury often presenting in the context of high velocity trauma. The aim of this study is to establish the subjective outcomes of surgically treated knee dislocations. A total of 20 knees dislocations treated by open repair were reviewed. Their progress and outcomes were assessed by using a modified Lysholm score questionnaire. Data was obtained on patient demographics, details of injury, investigation, treatment, rehabilitation, 24 months objective outcome and subjective outcomes. Six patients had a vascular deficit and six had neurological deficits. The median range of motion was 0°-100°. Patients with an initially lower pre-injury level of function were able to return an activity level comparable to their pre-injury status. 22% of competitive athletes retuned to competitive sports. 38% of patients undertaking heavy activity returned to comparable pre-injury level of activity and 67% of patients undertaking moderate level of activity before injury returned to a comparable level after repair. 68% regularly had problems running, 70% problem squatting, 40% swelling and 42% problem with stairs. Most patients however did not have locking of the knee or problems with knees giving way. Patients pain scores decreased over time to an acceptable level. Despite the severity of the injury, majority of patients achieved a satisfactory outcome, although none of the patients reached the same level of function as before the injury. 80% of the patients were satisfied with their outcome. All dissatisfied patients suffered postoperative complications.
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Kozanek, Michal, Samuel K. Van de Velde, Thomas J. Gill, and Guoan Li. "The Contralateral Knee Joint in Cruciate Ligament Deficiency." American Journal of Sports Medicine 36, no. 11 (July 14, 2008): 2151–57. http://dx.doi.org/10.1177/0363546508319051.

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Background Patients with unilateral ligament deficiency are believed to have altered kinematics of the contralateral knee, increasing the risk of contralateral joint injury. Therefore, the contralateral knees might not be a reliable normal kinematic control. Purpose To compare the in vivo kinematics of the uninjured contralateral knees of patients with anterior or posterior cruciate ligament deficiency with knee kinematics of age-matched patients without joint injury. Study Design Controlled laboratory study. Methods Ten subjects with bilateral healthy knees, 10 patients with acute unilateral anterior cruciate ligament injury, and 10 with acute unilateral posterior cruciate ligament injury participated in this study. Kinematics were measured from 0° to 90° of flexion using imaging and 3-dimensional modeling. Results No significant differences were found across the groups in all rotations and translations during weightbearing flexion (P > .9). Conclusion Patients with unilateral cruciate ligament deficiency did not alter kinematics of the contralateral uninjured knee during weightbearing flexion. In addition, these findings suggest that the included patients with anterior cruciate ligament or posterior cruciate ligament deficiency did not have preexisting abnormal kinematics of the knee. Clinical Relevance As the contralateral joint kinematics of the injured patients were not affected by the ipsilateral ligament injury in the short term, physicians and researchers might use the contralateral knee as a reliable normal kinematic control.
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Harvey, Jack, and Garron G. Weiker. "Acute Knee Injury in Wrestling." Physician and Sportsmedicine 17, no. 11 (November 1989): 70–78. http://dx.doi.org/10.1080/00913847.1989.11709913.

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Teh, J., G. Kambouroglou, and J. Newton. "Investigation of acute knee injury." BMJ 344, may25 1 (May 25, 2012): e3167-e3167. http://dx.doi.org/10.1136/bmj.e3167.

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Wu, Brian, Max Berger, Jonathan Sum, George Rick Hatch, and E. Todd Schroeder. "Acute vs Chronic Knee Injury- Basketball." Medicine & Science in Sports & Exercise 46 (May 2014): 287. http://dx.doi.org/10.1249/01.mss.0000494055.43002.b4.

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Roberson, Troy A., Thomas W. Throckmorton, Robert H. Miller, Richard A. Smith, and Frederick M. Azar. "Neurovascular injury in acute knee dislocation." Current Orthopaedic Practice 27, no. 5 (2016): 508–14. http://dx.doi.org/10.1097/bco.0000000000000404.

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Fomin, Sanne, Håkan Gauffin, and Joanna Kvist. "Short-term recovery of physical activity and knee function after an acute knee injury." BMJ Open Sport & Exercise Medicine 6, no. 1 (December 2020): e000950. http://dx.doi.org/10.1136/bmjsem-2020-000950.

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ObjectivesTo describe self-reported knee function, participation in physical activity and the number of knee surgeries at 3 and 6 months following acute knee injury.MethodsProspective cohort study. Participants, aged 15–40 years with an acute knee injury sustained no more than 6 weeks prior to inclusion, were recruited. There were 279 participants with ACL injury and 101 participants with other acute knee injuries included. Follow-up questionnaires were sent at 3 and 6 months after injury. Demographic information, activity participation, International Knee Documentation Committee subjective knee form (IKDC-SKF) and the Single Assessment Numeric Evaluation (SANE) score were collected. Additional knee injuries were obtained from self-report and medical charts.ResultsThe IKDC-SKF, SANE and physical activity participation were reduced at 3-month and 6-month follow-up. The number of participants who achieved health-promoting physical activity levels was reduced by 50% at 6-month follow-up compared with before injury. Seventeen per cent of participants with ACL injury and 41% of participants with other acute knee injuries had returned to their preinjury physical activity at 6 months. Participants with ACL injury reported worse knee function, lower physical activity participation and had more surgeries (128 surgeries, including 109 ACL-reconstructions) compared with participants with other acute knee injuries (six surgeries).ConclusionAcute knee injuries, including ACL injuries, affected self-reported knee function and physical activity participation for at least 6 months after index injury. More research is needed to understand how best to help people with acute knee injuries return to physical activity and achieve satisfactory knee function.
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Ferretti, Andrea, Edoardo Monaco, Andrea Redler, Giuseppe Argento, Angelo De Carli, Adnan Saithna, Paulo Victor Partezani Helito, and Camilo Partezani Helito. "High Prevalence of Anterolateral Ligament Abnormalities on MRI in Knees With Acute Anterior Cruciate Ligament Injuries: A Case-Control Series From the SANTI Study Group." Orthopaedic Journal of Sports Medicine 7, no. 6 (June 1, 2019): 232596711985291. http://dx.doi.org/10.1177/2325967119852916.

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Background: Broad variation in the reported rate of magnetic resonance imaging (MRI)–detected abnormalities of the anterolateral structures of the anterior cruciate ligament (ACL)–injured knee suggests a lack of reliability that has limited the use of MRI in clinical decision making. Purpose/Hypothesis: The aim of this study was to use MRI to determine the prevalence and spectrum of abnormalities of the anterolateral structures in acute ACL-injured knees, using the contralateral uninjured knee as a reference. We hypothesized that MRI evaluation of the acutely injured knee (using the uninjured knee as a reference) would allow reliable identification of abnormalities of the anterolateral structures. Study Design: Cohort study (diagnosis); Level of evidence, 3. Methods: Patients with acute ACL injury underwent MRI scan of both knees. Images were evaluated by 3 observers. Inter- and intraobserver reliabilities were determined for MRI parameters of anterolateral ligament (ALL) injury by use of the kappa (κ) test. Univariate and multivariate analyses were conducted to test associations between ALL abnormality and associated injuries. Results: A total of 34 patients were evaluated. Of these, 30 patients (88.2%) had at least 1 ALL abnormality in the ACL-injured knee (increased signal: n = 27[79.4%]; increased thickness: n = 15[44.1%]; tapering: n = 7[20.6%]; irregularities in the path of the ALL fibers: n = 21[61.7%]). Asymmetries of the genicular vessels were observed in 21 patients (61.7%). ALL abnormality was significantly associated with lateral joint capsular tears ( P < .001). No correlation was found between ALL lesions and iliotibial band lesions ( P = .49). Inter- and intraobserver reliabilities were very good concerning ALL signal changes and femoral and tibial bone bruises (κ coefficient, 0.81-1). Conclusion: MRI evaluation of the ALL was associated with good and very good inter- and intraobserver reliabilities, and it demonstrated abnormalities of the ALL in the majority of acutely ACL-injured knees. The index of suspicion for ALL injury should be elevated by the presence of lesions of the lateral capsule. This suggests that the ALL is part of a wider area of the lateral capsule that is often injured simultaneously in an acute ACL tear.
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Ptasznik, Ronald. "ULTRASOUND IN ACUTE AND CHRONIC KNEE INJURY." Radiologic Clinics of North America 37, no. 4 (July 1999): 797–830. http://dx.doi.org/10.1016/s0033-8389(05)70130-5.

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Cross, Mervyn J., Leo A. Pinczewski, and Desmond J. Bokor. "Acute Knee Injury in a Rock Musician." Physician and Sportsmedicine 17, no. 7 (July 1989): 79–82. http://dx.doi.org/10.1080/00913847.1989.11709827.

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Dissertations / Theses on the topic "Acute knee injury"

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Cattano, Nicole Marie. "Biomarker Response After an Acute Running Bout in Participants with and without an Acute Knee Injury History." Diss., Temple University Libraries, 2014. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/298162.

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Kinesiology
Ph.D.
The primary purposes of this study were to determine biomarker concentration levels at pre exercise and in response to an acute running bout in participants with an acute knee injury history (AKIH) in comparison to healthy control participants. The secondary purposes were to determine if self-perceived pre-exercise functional outcome score differences existed between participants with AKIH in comparison to healthy control participants, and whether these measures correlated with biomarker concentration changes after an acute running bout. Twenty-two (10 females, 12 males) college-aged individuals who were physically active participated in the study (11 with AKIH, 11 without AKIH). A two-group pre-test/post-test study design was utilized. The exercise bout consisted of running at 2.2 m * s -1 for 30 min on a motorized treadmill. Statistical significance was defined as p ≤ 0.05. The serum biomarker concentrations (i.e., COMP, IL-1ß, MMP-13, CTX-II, CPII, and CTX-II/CPII ratio) assessed in this study were not found to be significantly different based on AKIH status pre exercise and after 30 min of running. AKIH participants did have significantly lower pre-exercise functional scores compared to their matched healthy controls. Additionally, pre-exercise functional scores (i.e., KOOS quality of life and current Tegner activity) showed moderate negative correlations to IL-1ß and CTX-II/CPII ratio biomarker changes post exercise, respectively. The findings of this study indicate that an acute bout of moderate-intensity running is tolerated in a high-risk AKIH population and does not adversely affect knee biomarker metabolism. However, these findings should be interpreted with caution as it is yet to be determined if a higher exercise dose and/or intensity, as well as other varied types of exercise elicit adverse biomarker response within this population or if these findings are replicable in other populations (e.g., older aged). AKIH participants reported overall lower functional scores than healthy control participants, which may be indicative of impending structural or biomarker changes. Questions still remain about short- and long-term interventions post AKIH since there are many potential confounding factors that affect OA progression. Post-AKIH pathophysiology is complex and while there are unique variables that may accelerate OA onset, there may be an interaction effect of these variables that accelerate and propagate OA, and this still needs further investigation.
Temple University--Theses
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Hoch, Johanna M. "SERUM CARTILAGE OLIGOMERIC MATRIX PROTEIN: A BIOMARKER FOR ACUTE ARTICULAR CARTILAGE DAMAGE." UKnowledge, 2012. http://uknowledge.uky.edu/rehabsci_etds/3.

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Bone bruise lesions (BBL) are documented on MRIs diagnosing acute knee ligament injury (AKLI). Recent evidence has indicated that a majority of patients that sustain an AKLI, especially anterior cruciate ligament (ACL) knee injury, will develop post-traumatic osteoarthritis (PTOA) 10-20 years following injury. It has been proposed that the initial damage sustained to the articular cartilage overlying BBL causes a cascade of events that may result in PTOA. Researchers have proposed a modification to treatment protocols for more severe BBL, or have stressed the need for the development of protective therapies to protect the articular cartilage. However, there are limited tools available to evaluate the clinical outcome of articular cartilage overlying BBL. Furthermore, damage to the cartilage overlying BBL may be different according to differing BBL severities. Therefore, the use of a cartilage degradation biomarker, serum cartilage oligomeric matrix protein (sCOMP) and the use of a BBL severity classification system may be useful to determine if differences exist between patients with and without BBL, and with differing BBL severities. The purpose of this dissertation was to investigate the utility of sCOMP as a biomarker for acute articular cartilage damage. The purposes of these studies were to determine the inter and intraday reliability of this marker, to document sCOMP longitudinally in collegiate athletes and following AKLI, and to determine if differences in sCOMP and self-reported pain and function exist for patients with and without BBL, and differing BBL following AKLI. The results of these studies indicated sCOMP measures had strong inter and intraday reliability. Additionally, exercise does seem to influence sCOMP levels; however, these elevations may not be clinically meaningful. Furthermore, sCOMP levels were not different between patients with BBL and without, and between differing BBL severities. The results of these studies support the use of a BBL severity classification for future research studies in order to further elucidate the outcomes of these lesions.
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Ayre, Colin A. "Delay to diagnosis and specialist consultation following anterior cruciate ligament injury : a study investigating the nature of, and factors associated with, pathway delay." Thesis, University of Bradford, 2016. http://hdl.handle.net/10454/14627.

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Background: Historically the identification of ACL injuries upon initial presentation is low and considerable diagnostic delays have been reported. However, specific evidence on the individual elements of, and factors which influence delay, is lacking. Aims: The overarching aim was to provide a comprehensive picture of delay to diagnosis and specialist consultation, including factors which influence delay. An additional aim was to determine whether the approach to examining acute knee injuries varied as a consequence of varying patient presentation or experience of the assessing clinician. Methods: Study 1: Cross -sectional survey. Study 2: Non-participant direct observation methodology. Results: Data from 194 patients were analysed in the survey. Only 15.5% of patients were given a correct diagnosis of ACL rupture at the initial consultation. Median delay to diagnosis was 67.5 days (IQR= 15 to 178 days) and specialist consultation 108 days (IQR= 38 to 292 days). The factors most influential on delay were whether a follow-up appointment was arranged after attending A&E, whether the site of attendance operated an acute knee clinic and whether MRI was performed. The direct observation study showed wide variation in approach to injury assessment. Specialist clinicians performed the most comprehensive examination. A&E clinicians were more likely to assess for bony, neurovascular and gross tendon injuries as opposed to ligamentous or meniscal injury. Conclusions: The diagnostic rate of ACL injury at initial presentation remains low. Considerable delays to diagnosis and specialist consultation are apparent following ACL injury, the majority of which is attributable to health system delay.
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Åman, Malin. "Acute sports injuries in Sweden and their possible prevention : an epidemiological study using insurance data." Doctoral thesis, Gymnastik- och idrottshögskolan, GIH, Institutionen för idrotts- och hälsovetenskap, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-5128.

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Physical activity is an essential component of a healthy life, e.g. to prevent obesity, cardiovascular disease and premature death, of which sports can be an important part. Unfortunately, sports activities increase the risk of both overuse and acute injuries. Severe acute injuries may also lead to a permanent medical impairment (PMI), which may influence the ability to be physically active throughout life. However, sports injuries may be prevented, but a profound understanding of the injuries and how to prevent them is needed. This doctoral thesis examine acute sports injuries reported by licensed athletes of all ages and level of sports nationwide in Sweden, by using national insurance data. Approximately 80% of all the Sports Federations (SF) had their mandatory accident insurance in the insurance company Folksam, and since there is no national sports injury surveillance system in Sweden, this is a unique database, able to be used in epidemiological studies on acute injuries occurring in organized sports in Sweden. The main aim of this thesis was to identify high-risk sports for acute injuries, the most common and the most severe injuries, especially in large sports with numerous licensed athletes, many injuries and injuries resulting in PMI. Based on the results, there will be recommendations regarding sports and body locations where injury prevention efforts should be focused to gain the greatest prevention effect at a national level in Sweden. Another aim was to evaluate the effectiveness of a neuromuscular knee control training program (KCP) that has been implemented nationwide to reduce knee and cruciate ligament injuries, among football players in Sweden. After evaluating the validity and reliability of the information within the database based on international guidelines, acute injury data were examined and the results presented in four papers. These results showed that there is a need of injury prevention especially in motorcycle sports, team ball sports, and ice hockey. Particularly, knee injuries need to be prevented since they were both the most common injuries and leading to PMI. The severe head- and upper limb injuries also need attention. Sixty-nine percent of the PMI injured athletes, were younger than 25 years. The injury prevention training program, KCP can be considered partially implemented nationwide, since 21 out of 24 district SFs provided KCP educations. The incidence of knee and cruciate ligament injuries has decreased among football players in Sweden. A concerning aspect is that there is no national official policy regarding sports injury and injury prevention in Sweden, nor an official authority that has the explicit responsibility for these issues.
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Martinez, Austin A. "A Comparison of the Diagnostic Accuracy of Three Diagnostic Tests for Anterior Cruciate Ligament Lesions." Ohio University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1491775474846951.

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Books on the topic "Acute knee injury"

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Lee, Christoph I. Decision Rule for Imaging Acute Knee Injuries. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190223700.003.0032.

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This chapter, found in the bone, joint, and extremity pain section of the book, provides a succinct synopsis of a key study examining the use of the Ottawa knee rules for imaging acute knee injuries. This summary outlines the study methodology and design, major results, limitations and criticisms, related studies and additional information, and clinical implications. The Ottawa Knee Rule was found to be highly accurate, reliable, and acceptable to emergency physicians. Adherence to the decision rule has the potential to reduce unnecessary radiography in acute knee injury cases by 28%. In addition to outlining the most salient features of the study, a clinical vignette and imaging example are included in order to provide relevant clinical context.
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Williams, Andy, and Ali Narvani. Combined ligament injuries around the knee. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199550647.003.008012.

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♦ Any knee with major disruption of two ligaments is likely to have been dislocated at the time of injury♦ Knee dislocations are associated with high risk of neurovascular injury. Angiography or vascular ultrasound is mandatory♦ In knee dislocations, following immediate reduction and stabilization usually with a brace, acute repair of the ruptured soft tissue structure within 2–3 weeks of injury is likely to provide superior results compared to later reconstruction♦ Management of most multiligament injuries is complex and requires surgical intervention therefore specialist centres are best to be involved early♦ In cases with associated malalignment, osteotomy can improve the results of ligament reconstruction.
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Jones, Bryn. Complications of total knee replacement. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199550647.003.008007.

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♦ 81–89% overall patient satisfaction following total knee replacement♦ 1 in 8 patients experience unexplained postoperative pain♦ Obesity, increasing age, and medical comorbidities increase the risk of postoperative complications♦ Prosthetic infection rate at 1 year is 1–2%♦ Preoperative range of movement often determines postoperative range♦ Low risk of acute vascular event and neurological and ligamentous injury♦ Duration and method of venous thromboprophylaxis remains controversial♦ Periprosthetic femoral and tibial fractures require stabilisation. Fixation of periprosthetic patella fractures is not recommended♦ New surgical techniques and innovations require long term evaluation.
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Thomas, Simon, and Michael Walton. Sports injuries and syndromes. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199550647.003.013023.

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♦ Paediatric sports medicine is an evolving multidisciplinary specialty with increasing rates of injury in paediatric athletes:• Injury prevention programmes are important• Training regimes must be adapted to the age group and the sport♦ Sports injuries to the immature skeleton require different treatment approaches to those in adults even when injury patterns appear similar♦ The knee is the most commonly injured region—anterior cruciate ligament ruptures in children and adolescents are higher than previously appreciated♦ Upper limb paediatric sports injuries are more commonly secondary to overuse than acute injury—physiotherapy and activity modification are the mainstays of treatment.
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Book chapters on the topic "Acute knee injury"

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Bonasia, Davide Edoardo, Roberto Rossi, Federica Rosso, Umberto Cottino, Corrado Bertolo, and Filippo Castoldi. "Acute Medial and Posteromedial Injury." In Knee Ligament Injuries, 17–26. Milano: Springer Milan, 2014. http://dx.doi.org/10.1007/978-88-470-5513-1_3.

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Miller, Mark D., and Matthew T. Burrus. "Acute Lateral and Posterolateral Injury." In Knee Ligament Injuries, 27–38. Milano: Springer Milan, 2014. http://dx.doi.org/10.1007/978-88-470-5513-1_4.

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Kurosawa, Hisashi. "Conservative Repair for Acute Anterior Cruciate Ligament Injury." In Reconstruction of the Knee Joint, 28–35. Tokyo: Springer Japan, 1997. http://dx.doi.org/10.1007/978-4-431-68464-0_6.

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Kurosawa, H., A. Kawakami, M. Oshida, and I. Onishi. "Healing Can Be Expected for Acute Anterior Cruciate Ligament Injury." In Reconstruction of the Knee Joint, 5. Tokyo: Springer Japan, 1997. http://dx.doi.org/10.1007/978-4-431-68464-0_3.

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Pierce, Casey M., and Robert F. LaPrade. "ACL Injuries Combined with Lateral and Medial Knee Injuries Acute Versus Chronic Injury: What to Do." In The ACL-Deficient Knee, 293–310. London: Springer London, 2012. http://dx.doi.org/10.1007/978-1-4471-4270-6_25.

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Monahan, Timothy J. "Management of Acute and Chronic Nerve Injuries." In The Multiple Ligament Injured Knee, 167–83. New York, NY: Springer New York, 2004. http://dx.doi.org/10.1007/978-0-387-22522-7_11.

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Kopka, Michaela, and S. Mark Heard. "Surgical Treatment of Combined PCL/Lateral Side Injuries: Acute and Chronic." In The Multiple Ligament Injured Knee, 227–44. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-05396-3_15.

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Tuman, Jeffrey M., and Mark D. Miller. "Surgical Treatment of Combined PCL Medial Side Injuries: Acute and Chronic." In The Multiple Ligament Injured Knee, 245–53. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-05396-3_16.

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Hoit, Graeme, Ujash Sheth, and Daniel B. Whelan. "Initial Assessment in the Acute and Chronic Multiple-Ligament-Injured Knee." In The Multiple Ligament Injured Knee, 55–66. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-05396-3_4.

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Gomberawalla, M. Mustafa, and Jon K. Sekiya. "Surgical Treatment of Combined PCL/Lateral-Sided Injuries: Acute and Chronic." In The Multiple Ligament Injured Knee, 211–26. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-0-387-49289-6_15.

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Conference papers on the topic "Acute knee injury"

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Meyer, Eric G., Daniel I. Isaac, Tammy L. Haut Donahue, Loïc M. Déjardin, and Roger C. Haut. "Comparisons of the Joint Responses to Surgical Transection and Traumatic Rupture of the ACL in a Rabbit Model." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53526.

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Long-term participation in vigorous physical activity increases the risk of acute and chronic injuries to the knee. Two specific types of injury strongly associated with subsequent knee osteoarthritis (OA) are cruciate ligament damage and meniscal tears. Many clinical studies have discussed the high frequency of noncontact ACL injuries, for example, from jump landings. Axial compressive loading of the knee during landing from a jump can generate approximately 6–8 times bodyweight. With the tibial plateau having an inherent posterior slope of 10–15°, these loads can produce an anterior shift of the tibia during jump landings that result in isolated rupture of the anterior cruciate ligament (ACL) in the laboratory.1 These studies have shown acute damages in the articular cartilage and underlying subchondral and trabecular bone in the human cadaver joint.2 Clinically, in over 80% of ACL injury cases, characteristic osteochondral lesions occur in the posterolateral aspect of the tibia and/or anterolateral aspect of the lateral femoral condyle, potentially due to these levels of joint compressive loads.3
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Killian, Megan L., Dan Isaac, Roger C. Haut, Loic M. Dejardin, Darin Leetun, and T. L. Haut Donahue. "Traumatic Anterior Cruciate Ligament Tear and Its Implications on Meniscal Degradation: A Preliminary Novel Lapine Osteoarthritis Model." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-205106.

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The meniscus plays a crucial role in the dynamics of the knee. Damage to the meniscus can influence proprioception, stability, and mobility of the knee [1]. Risk factors of meniscal tears include prolonged or repeated deep knee bending, obesity, and sporting injuries [2]. Acute injury, as seen in alpine sports, involves complex dynamics which can damage singular or multiple tissue structures of the knee [2]. It is not uncommon for meniscal injuries to occur in conjunction with ACL lesions, and the loading imbalance that results in ACL lesions may also initiate meniscal tears [3, 4]. Investigations of meniscal tears following ACL rupture have indicated chronic damage to medial menisci more so than lateral menisci [5]. However, experimental studies of acute damage following ACL transection are not consistent, with some showing more lateral damage acutely and some showing equality between medial and lateral meniscal damage [5].
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Kiapour, Ata M., Constantine K. Demetropoulos, Ali Kiapour, Carmen E. Quatman, Jason W. Levine, Samuel C. Wordeman, Timothy E. Hewett, and Vijay K. Goel. "ACL Injury Mechanism is Related to Articular Pressure Distribution: A Cadaveric and Finite Element Investigation." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80659.

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Acute anterior cruciate ligament (ACL) injury can be devastating, and often results in clinical sequelae that include meniscal tears, chondral lesions and osteoarthritis. Various bone bruise patterns of the femur or tibia, and bone contusions of the lateral tibial plateau have been associated in more than 80% of partial or complete ACL ruptures [1]. As quantification of articular cartilage pressure distribution under high-rate loading conditions remains challenging, validated finite element (FE) models of the knee can be used to characterize the effects of different loading parameters on tibiofemoral (TF) joint pressure distribution. This study combines high-rate cadaveric experiments with FE analysis to simulate ACL injuries and associated bone bruise patterns following landing from a jump. We hypothesized that a potential relationship exists between ACL injury mechanisms and resultant tibial plateau bone bruise patterns. This relationship may enhance our understanding of ACL injury mechanisms, which may provide insight to improve current prevention strategies that aim to decrease the risk of ACL injury and damage to secondary anatomical structures. All of this may in turn minimize associated posttraumatic knee osteoarthritis.
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Abraham, Adam C., Megan L. Killian, Roger C. Haut, and Tammy L. Haut Donahue. "Long Term Effect of P188 on Meniscus Preservation Following Blunt Trauma." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80775.

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Acute knee joint injury has been associated with the development and progression of secondary osteoarthritis (OA). Previous work implicates that acute damage to tissue matrix and cells of the meniscus and articular cartilage may play important roles in early-stage OA [1]. Additionally, it has been shown that articular cartilage matrix repair hinges on chondrocyte preservation [2]. Therefore, inhibition of cell death may halt tissue degeneration. Recently, the FDA-approved surfactant Poloxamer 188 (P-188) has been shown to decrease acute cell death by repair of its plasma membrane, as well as mediate p38 signaling and subsequent inflammatory and apoptotic signaling leading to a reduction in degeneration of impacted cartilage [3, 4]. Therefore, it was hypothesized that matrix glycosaminoglycans of the meniscus will be preserved in the long-term following traumatic impaction and subsequent treatment with P-188.
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Ewers, Benjamin J., Vijay M. Jayaraman, Richard F. Banglmaier, and Roger C. Haut. "The Effect of Loading Rate on the Degree of Acute Injury and Chronic Conditions in the Knee After Blunt Impact." In 44th Stapp Car Crash Conference (2000). 400 Commonwealth Drive, Warrendale, PA, United States: SAE International, 2000. http://dx.doi.org/10.4271/2000-01-sc20.

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6

Vernon, Lauren L., David G. Wilensky, Chong Wang, Lee D. Kaplan, and Chun-Yuh C. Huang. "Mechanical Loading Reduces Chondrocyte Death After Single Impact Trauma: Porcine Knee Model." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80833.

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Osteoarthritis often results from degenerative changes induced by trauma such as joint impact injuries sustained during athletics, combat, or motor vehicle accidents. Articular cartilage, avascular in nature, relies of synovial nutrition [1] and lacks sufficient regenerative capabilities [2]. Acute cartilage injuries have been shown to induce cell death [3, 4, 5], leading to reduced chondrocyte density and degenerative changes to the cartilage matrix composition; over time the tissue becomes compromised and loses its ability to maintain and restore itself. It has been demonstrated, that mechanical loading can affect local perfusion and diffusion through the matrix thereby altering the flow of nutrients and metabolites [2, 6]. Furthermore, mechanical loading modulates the chondrocyte biosynthesis of extracellular matrix that is required in the cartilage repair process. In this study, a two part in-vitro porcine knee model was utilized to investigate articular cartilage response immediately following a single impact injury under cyclic mechanical loading conditions.
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Roemer, F., M. Englund, A. Turkiewicz, A. Struglics, A. Guermazi, L. S. Lohmander, S. Larsson, and R. Frobell. "OP0056 Molecular and structural biomarkers of inflammation at 2 years after acute acl injury do not predict structural knee osteoarthritis at 5 years." In Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, 13–16 June 2018. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. http://dx.doi.org/10.1136/annrheumdis-2018-eular.2060.

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8

Killian, Megan L., Roger C. Haut, and Tammy L. Haut Donahue. "Closed Joint Traumatic Impaction and Its Influence on Meniscal Cell Viability." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53001.

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Traumatic impaction is known to cause acute cell death and macroscopic damage to cartilage and menisci in vitro1,2,3. It is understood that damage to the menisci can lead to chronic problems associated with excessive cartilage wear and the eventual onset of osteoarthritis (OA)4. Additionally, cartilage fissuring, subchondral bone bruising, and chondrocyte death are also believed to lead to the rapid progression of joint degeneration5. Such injuries, along with posterolateral meniscal tearing, are often observed after traumatic impaction and anterior cruciate ligament (ACL) rupture6–9. Therefore, understanding how the menisci and cartilage respond acutely to impaction may help guide future therapies following traumatic knee injury in order to prevent the development of OA.
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Button, Keith D., Kevin M. Leikert, Ryan S. Fajardo, Tammy L. Haut Donahue, and Roger C. Haut. "Development of a Traumatic Anterior Cruciate Ligament and Meniscal Rupture Model to Study Osteoarthritis." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14287.

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Participation in sports, recreation, and exercise is progressively gaining more popularity in American culture and, along with it, the risk of acute and chronic injuries. People who injure a knee before the age of 22 have a greater than 3-fold risk of developing osteoarthritis (OA) in the injured joint by their mid 50s 5. Specifically, anterior cruciate ligament (ACL) and meniscal injuries are strongly associated with the development of OA 4, a common and widespread musculoskeletal disease 1.
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DeVries, Nicole A., Matthew J. Bollier, and Nicole M. Grosland. "Affect of Attachment Site on Medial Patellofemoral Ligament Reconstruction: A Finite Element Analysis." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14164.

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Bony anatomy, soft tissue restraints, and the dynamic action of the quadriceps all play a role in maintaining patellar stability throughout knee motion. The medial patellofemoral ligament (MPFL) is the main soft tissue restraint to lateral translation of the patella, and helps guide the patella into the trochlear groove during the first 30° of knee flexion [1]. Studies have shown that the MPFL is the most consistently injured anatomical structure after acute lateral patellar dislocation [2]. Due to the high rate of recurrent episodes of instability following conservative management of acute lateral patellar dislocation, a number of bony and soft tissue procedures have been described to restore patellar stability, including MPFL reconstruction [2].
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