Academic literature on the topic 'Acute Leukaemia'

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Journal articles on the topic "Acute Leukaemia"

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Sarrou, Evgenia, Laura Richmond, Ruaidhrí J. Carmody, Brenda Gibson, and Karen Keeshan. "CRISPR Gene Editing of Murine Blood Stem and Progenitor Cells Induces MLL-AF9 Chromosomal Translocation and MLL-AF9 Leukaemogenesis." International Journal of Molecular Sciences 21, no. 12 (2020): 4266. http://dx.doi.org/10.3390/ijms21124266.

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Chromosomal rearrangements of the mixed lineage leukaemia (MLL, also known as KMT2A) gene on chromosome 11q23 are amongst the most common genetic abnormalities observed in human acute leukaemias. MLL rearrangements (MLLr) are the most common cytogenetic abnormalities in infant and childhood acute myeloid leukaemia (AML) and acute lymphocytic leukaemia (ALL) and do not normally acquire secondary mutations compared to other leukaemias. To model these leukaemias, we have used clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 gene editing to induce MLL-AF9 (MA9) chromosomal r
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Kuzmits, Rudolf, Paul Aiginger, Matthias M. Müller, Günter Steurer, and Werner Linkesch. "Assessment of the sensitivity of leukaemic cells to cytotoxic drugs by bioluminescence measurement of ATP in cultured cells." Clinical Science 71, no. 1 (1986): 81–88. http://dx.doi.org/10.1042/cs0710081.

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1. A short-term test in vitro is described, which can be used to detect resistance to cytostatic agents in leukaemic cells. Leukaemic cell suspensions were incubated with cytostatic agents and the resulting intracellular ATP concentrations were measured by a bioluminescence ATP assay. 2. There was a clear dose-effect relationship in acute leukaemia and chronic lymphocytic leukaemia cells for drugs used in the treatment of leukaemias. A good correlation was found between the ATP content of leukaemic cells and cell viability as determined by the trypan blue dye exclusion test. 3. Preliminary ind
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Siraj, Sayada, Chandra Rani Sarker, and Fahmiah Begum. "Relationship of Serum Uric Acid and Serum Creatinine Levels with Total Count of WBC in Acute Leukaemia." Haematology Journal of Bangladesh 8, no. 2 (2024): 56–62. https://doi.org/10.37545/haematoljbd2024133.

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Background: Leukaemia is uncontrolled proliferation of white blood cells caused by mutation of myelogenous or lymphogenous cells which are usually characterized by increased number of white blood cells in the blood. Leukaemia accounts for about four percent of all death from malignant disease. The incidence of acute leukaemia is about 10 per lac per year. Acute leukaemia can occur at any age. The cause of leukaemia is unknown in most patients. Serum uric acid and creatinine levels increased and positively correlated with total count of WBC in acute leukaemic patients. Objective: Objective of o
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Skarsgård, Lisa Stenman, Mattias K. Andersson, Marta Persson, et al. "Clinical and genomic features of adult and paediatric acute leukaemias with ophthalmic manifestations." BMJ Open Ophthalmology 4, no. 1 (2019): e000362. http://dx.doi.org/10.1136/bmjophth-2019-000362.

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ObjectiveTo describe the clinicopathological and genomic features of nine patients with primary and secondary orbital/ocular manifestations of leukaemia.MethodsAll orbital/ocular leukaemic specimens from 1980 to 2009 were collected from the Danish Register of Pathology. In six cases, medical records and formalin-fixed, paraffin-embedded blocks were available. Three cases from the Department of Pathology, Royal Liverpool University Hospital, were also included. Immunophenotypes and MYB oncoprotein expression were ascertained by immunohistochemistry. Genomic imbalances were analysed with compara
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Nurunnabi, Md, Mosammath Khadiza Mamdu, Ayesha Siddika, Farzana Zafreen, Md Abdul Wahab, and Shahana Shermin. "Morphological and Immunophenotypic Analysis in Diagnosis of Acute Leukaemia." Delta Medical College Journal 8, no. 1 (2022): 15–20. http://dx.doi.org/10.3329/dmcj.v8i1.58958.

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Background: Leukaemias are neoplastic proliferations of haematopoietic stem cells and form a major proportion of haematopoietic neoplasms that are diagnosed worldwide.
 Objective: To differentiate between morphological and immunophenotypic analysis in the diagnosis of acute leukemia.
 Materials and method: This cross sectional study was conducted in the department of Haematology, Armed Forces Institute of Pathology (AFIP), Dhaka, Bangladesh from January 2008 to December 2008. Total 50 patients were included after fulfilling inclusion and exclusion criteria.
 Results: The total o
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Ivanovic, Mirjana, Olivera Jovicic, Jelena Mandic, Dusko Bogetic, and Marcello Maddalone. "Oral manifestations of acute leukaemia." Srpski arhiv za celokupno lekarstvo 139, no. 1-2 (2011): 103–6. http://dx.doi.org/10.2298/sarh1102103i.

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Acute leukaemia is the most common form of chilhood cancer. The aim of this paper was to underline the importance of oral manifestations in children with acute leukaemia. The disease and its treatment can directly or indirectly affect oral health. Oral manifestations are gingival inflammation and enlargement. Leukaemic cells are capable of infiltrating the gingiva and the deeper periodontal tissues which leads to ulceration and infection of oral tissues. Gingival bleeding is a common sign in patients with leukaemia. Symptoms include local lymphadenopathy, mucous membrane Petechiae and ecchymos
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Hossain, Ireen, Niaz Abdur Rahman, and Syeed Mehbub Ul Kadir. "Severe Leukemic Retinopathy due to Acute Lymphoblastic leukemia." Community Based Medical Journal 13, no. 2 (2024): 277–81. http://dx.doi.org/10.3329/cbmj.v13i2.75322.

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Leukaemia is a myeloproliferative disorder which commonly affects the eye. The retina is most commonly affected by leukaemia. Both acute and chronic leukaemia can develop retinopathy. Patients can develop anaemia and thrombocytopenia. The ophthalmic features include white-centred retinal haemorrhages (Roth spot), cotton wool spots, macular haemorrhages and vitreous haemorrhages. CNS involvement through the optic nerve can cause papillo-oedema and cranial nerve palsy. Opportunistic infection can occur after chemotherapy. A young female patient was diagnosed with Acute Lymphoblastic leukaemia (A
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Jyoti, Ranjan Behera, Ranjan Mallick Manas, Kumar Tripathy Sandeep, Kumari Behera Pranati, and Behera Narendra. "Prevalance of Acute Leukemia in Children with Special Reference to Immunocytochemistry." International Journal of Pharmaceutical and Clinical Research 15, no. 11 (2023): 525–31. https://doi.org/10.5281/zenodo.11217522.

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<strong>Introduction:&nbsp;</strong>There are 50 to 200 cases of paediatric cancer for every million children worldwide. In developing nations, juvenile cancer accounts for 2% of all cancer cases and 0.5% of those in more industrialised nations. Children&rsquo;s malignancies that are common worldwide include lymphoma and leukaemia. Childhood cancers most commonly diagnosed in industrialised and developing nations include leukaemias, which are the most prevalent kind, and lymphomas. It is estimated that leukaemia makes up one-third of childhood cancer cases, with acute lymphoblastic leukaemia (
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Budi, Luh Putu Rihayani, Ketut Ariawati, and Sianny Herawati. "NEONATAL ACUTE MYELOID LEUKAEMIA." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 19, no. 3 (2016): 211. http://dx.doi.org/10.24293/ijcpml.v19i3.417.

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Acute myeloid leukaemia (AML) is a. malignant, clonally disease that involves proliferation of blasts in bone marrow, blood, or other tissue. The blasts most often show myeloid or monocytic differentiation. The incidence of AML increases with age, but when neonatal leukaemia does occur, it is paradoxically AML rather than ALL. All the signs and symptoms that present on patient with AML are caused by the infiltration of the bone marrow with leukaemic cells and resulting failure of normal haematopoiesis. Without the normal haematopoietic elements, the patient is at risk for developing life-threa
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Dachi. "Acute Leukaemias in Bauchi State, Northeastern Nigeria: Pattern of Presentations and Clinical Entities." West Africa Journal of Medicine 39, no. 5 (2022): 497–500. http://dx.doi.org/10.55891/wajm.v39i5.122.

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Background: Acute leukaemias are very aggressive diseases that run a rapidly fatal course if not promptly diagnosed and appropriately treated. The clinical presentations range from bone marrow failure such as anaemia, neutropenia or thrombocytopenia to features of organ infiltrations such as lymphadenopathy, splenomegaly, etc, but presentations may be non-specific. Misdiagnosis is very common with delay in diagnosis and prompt treatment being the causes of high morbidity and mortality in acute leukaemias. This study aims to determine the pattern of presentation and various clinical entities of
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Dissertations / Theses on the topic "Acute Leukaemia"

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Bomken, Simon Nicholas. "Investigating leukaemic propagation in childhood acute lymphoblastic leukaemia." Thesis, University of Newcastle Upon Tyne, 2013. http://hdl.handle.net/10443/1865.

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Childhood acute lymphoblastic leukaemia (ALL) does not possess a propagating cell hierarchy, at least as defined by B-cell precursor immunophenotype. Indeed, many, or even all, leukaemic blasts may have the potential to propagate the disease. This unusual characteristic mirrors the substantial capacity for clonal expansion demonstrated by fully differentiated normal lymphoid cells. This Fellowship aimed to investigate the genetic programmes underlying the propagation of acute lymphoblastic leukaemia. An initial candidate approach confirmed the expression of PIWIL2, a gene critical to the maint
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Bradbury, Dawn Ann. "Factors regulating the autocrine growth of leukaemic cells in acute myeloblastic leukaemia." Thesis, Nottingham Trent University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.332817.

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Knapper, Steven. "FLT3 inhibitors in acute myeloid leukaemia." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432548.

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Smith, Matthew Liam Walker. "Mutation profiling in acute myeloid leukaemia." Thesis, Queen Mary, University of London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.416112.

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Quinn, M. F. "Homeobox gene expression in acute leukaemia." Thesis, Queen's University Belfast, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398094.

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Abadir, Edward. "Novel Targets in Acute Myeloid Leukaemia." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/23677.

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Background: Antibody based immunotherapies have revolutionised the treatment of haematological malignancies. Despite recent advances in Acute Myeloid Leukaemia (AML) most patients still have poor outcomes. Current surface targets in AML are not ideal and ongoing work is required to examine new antigens for meaningful clinical outcomes. Hypothesis: CD302 and CD300f have inherent properties that make them promising potential targets in AML. Preclinical work will establish these antigens as suitable targets in AML for further study. Methods: We looked at the distribution of CD302 on AML and Haema
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Mannari, Deepak. "The genomics of acute myeloid leukaemia : an investigation into the molecular pathogenesis of acute myeloid leukaemia with t(8;21)." Thesis, Queen Mary, University of London, 2012. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8822.

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Acute myeloid leukaemia is a clonal disorder characterised by recurrent chromosomal translocations. One of the commonest, is the t(8;21) which results in part of the AML1 gene being juxtaposed to most of the ETO gene with the resultant chimeric protein, AML1-ETO, acting predominantly as a transcriptional repressor. Despite the extensive literature available, the exact mechanism by which the chimeric protein results in AML has not been fully elucidated. By using exon arrays and high throughput sequencing as tools it was hoped to gain further insights into the molecular basis of this disease. Ge
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Swanepoel, Yolande. "A retrospective study of acute lymphoblastic leukaemia in Paediatric patients at Dr George Mukhari Hospital (2003-2007)." Thesis, University of Limpopo (Medunsa Campus), 2008. http://hdl.handle.net/10386/262.

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Thesis (M Med(Haematology))-- University of Limpopo (Medunsa Campus), 2008.<br>Introduction: ALL (Acute Lymphoblastic Leukaemia) is the most common leukaemia in childhood. The two most important features predictive of outcome are age and presenting WBC at diagnosis. NCI risk criteria are applied to all children with precursor B-ALL, dividing them into NCI “high risk” (age < 1 year and ≥ 10 yrs, WBC > 50 x 10 9/ ) and NCI “standard risk” (age ≥ 1 year and < 10 yrs, WBC < 50 x 10 9/ ). Gender, immunophenotyping and genetic studies are other features that have been shown to be associated with
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Taussig, David. "Characterisation of acute myeloid leukaemia stem cells." Thesis, Queen Mary, University of London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424766.

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Cartwright, Cher Suzanne. "Thiopurine Metabolism in Childhood Acute Lymphoblastic Leukaemia." Thesis, University of Sheffield, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500442.

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Books on the topic "Acute Leukaemia"

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S, Tallman Martin, ed. Acute promyelocytic leukaemia. Baillière Tindall, 2003.

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D, Hoelzer, ed. Acute lymphoblastic leukaemia. Baillière Tindall, 1994.

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D, Hoelzer, and Gökbuget Nicola, eds. Acute lymphocytic leukaemia. Baillière Tindall, 2002.

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K, Burnett Alan, ed. Acute myeloid leukaemia. Baillière Tindall, 2001.

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B, Löwenberg, ed. Acute myelogenous leukaemia and myelodysplasia. Baillière Tindall, 1996.

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Olwill, Shane. Annexin II expression in acute myeloid leukaemia. The author], 2003.

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Barge, A. Acute myeloid leukaemia: The role of haematopoietic growth factors. Gardner-Caldwell Communications, 1998.

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National Institute for Clinical Excellence. Guidance on the use of imatinib for chronic myeloid leukaemia. National Institute for Clinical Excellence, 2002.

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National Institute for Clinical Excellence. Guidance on the use of imatinib for chronic myeloid leukaemia. National Institute for Clinical Excellence, 2003.

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Raybould, Simon. Spatial analysis of acute lymphoblastic leukaemia in Tyne and Wear. University of Newcastle upon Tyne Centre for Urban and Regional Development Studies, 1987.

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Book chapters on the topic "Acute Leukaemia"

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Monfardini, S., K. Brunner, D. Crowther, et al. "Acute Leukaemia." In Manual of Adult and Paediatric Medical Oncology. Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-82489-0_13.

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von Wolff, Michael, Nicola Gökbuget, and Andrea Jarisch. "Acute Leukaemia." In Fertility Preservation in Oncological and Non-Oncological Diseases. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-47568-0_8.

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Schwab, Claire, and Christine J. Harrison. "Acute Lymphoblastic Leukaemia." In Methods in Molecular Biology. Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-074-4_8.

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Willoughby, M. L. N., and B. Lampkin. "Acute Myeloid Leukaemia." In Cancer in Children. Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-84722-6_10.

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Riehm, H., W. Ebell, H. J. Feickert, and A. Reiter. "Acute Lymphoblastic Leukaemia." In Cancer in Children. Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-84722-6_9.

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Smith, Matthew L., and Thomas McKerrell. "Acute myeloid leukaemia." In The Genetic Basis of Haematological Cancers. John Wiley & Sons, Ltd, 2016. http://dx.doi.org/10.1002/9781118527948.ch3.

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Andersson, Anna, Anthony V. Moorman, Christine J. Harrison, and Charles Mullighan. "Acute lymphoblastic leukaemia." In The Genetic Basis of Haematological Cancers. John Wiley & Sons, Ltd, 2016. http://dx.doi.org/10.1002/9781118527948.ch5.

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Mughal, Tariq I. "Acute Myeloid Leukaemia." In Precision Haematological Cancer Medicine. CRC Press, 2018. http://dx.doi.org/10.1201/9781315380513-4.

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Mughal, Tariq I. "Acute Lymphoblastic Leukaemia." In Precision Haematological Cancer Medicine. CRC Press, 2018. http://dx.doi.org/10.1201/9781315380513-5.

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Riehm, H., H. J. Feickert, and F. Lampert. "Acute Lymphoblastic Leukaemia." In Cancer in Children. Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-96889-1_12.

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Conference papers on the topic "Acute Leukaemia"

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Bykowska, K., S. Lapaciuk, M. Janczarski, Z. Wegrzynowicz, and M. Kopec. "PLASMA FIBRONECTIN IN ACUTE LEUKAEMIAS AND DURING STREPTOKINASE THERAPY." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643557.

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We have previously shown that digestion of fibronectin (FN) by trypsin, kallikrein and plasmin influences strongly the FN quantitation by electroimmunoassay (EIA) and immunoturbidimetric assay (ITA). Proteolytic degradation led to an overestimation of FN by EIA but to a decline of results in ITA (Thromb.Haemostas., 53:377, 1985). In this study plasma FN was determined in parallel by EIA and ITA in adult patients with acute leukaemia prior to chemotherapy and in patients treated with SK for DVT. It has been assumed that in leukaemias leukocytic proteases can degrade FN. In 24 control subjects,
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Curti, Antonio. "Acute myeloid leukaemia: First debate on leukaemia biology." In The 4th European Congress Controversies in Leukemias Brussels, Belgium 20-21 November, 2023, edited by Alessandro Isidori. Medicom Medical Publishers, 2024. http://dx.doi.org/10.55788/5f3943ab.

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Tirtakusuma, RF, S. Bomken, and O. Heidenreich. "Control of Lineage Commitment in Acute Leukaemia." In 30. Jahrestagung der Kind-Philipp-Stiftung für pädiatrisch-onkologische Forschung. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1602223.

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Armenteros-Monterroso, E., L. Zhao, J. de Boer, and O. Williams. "Investigating Reptin function in Acute Myeloid Leukaemia." In 30. Jahrestagung der Kind-Philipp-Stiftung für pädiatrisch-onkologische Forschung. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1602188.

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Negi, Amit, Jyoti Rawat, Chirag Gupta, Swapnil Joshi, and Mansi Pathak. "Ensemble CAD System for Acute Lymphoblastic Leukaemia Classification." In 2022 3rd International Conference on Intelligent Engineering and Management (ICIEM). IEEE, 2022. http://dx.doi.org/10.1109/iciem54221.2022.9853051.

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Wilde, J. T., S. Kitchen, F. E. Freston, and M. Greaves. "A COMPARISON OF D-DIMER AND SERUM FIBRINOGEN/FIBRIN DEGRADATION PRODUCT LEVELS (F.D.P.’s) IN THE INVESTIGATION OF HYPERCOAGULABLE STATES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643138.

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D-Dimer assays measure specific breakdown products of crosslinked fibrin whereas FDP assays are not specific for these products. We have, therefore, measured D-Dimer levels (MabCo Dimer Test) semi-quantitatively in patients with clinical and laboratory evidence of disseminated intravascular coagulation, acute and chronic liver disease, acute leukaemia at presentation and acute venous thrombosis at diagnosis. We have also measured D-Dimer in the 3rd trimester of normal pregnancy and in pregnancies with complications. We compared these levels with F.D.P. levels measured by the Thrombo-Wellcotest
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Mitel, Alina, Carmen Burloiu, Alexandru Capisizu, and Monica Luminos. "P137 Case presentation: diagnostic difficulties in acute lymphoblastic leukaemia." In 8th Europaediatrics Congress jointly held with, The 13th National Congress of Romanian Pediatrics Society, 7–10 June 2017, Palace of Parliament, Romania, Paediatrics building bridges across Europe. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2017. http://dx.doi.org/10.1136/archdischild-2017-313273.225.

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Pal, D., H. Blair, S. Boyd, et al. "The human bone marrow (BM) niche in acute leukaemia." In 30. Jahrestagung der Kind-Philipp-Stiftung für pädiatrisch-onkologische Forschung. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1602218.

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Clesham, KJ, L. Gasparoli, C. Virely, S. Cantilena, J. De Boer, and O. Williams. "Targeting c-MYB in Acute Leukaemia through Drug Repositioning." In 32. Jahrestagung der Kind-Philipp-Stiftung für pädiatrisch onkologische Forschung. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1687158.

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Verma, Deepesh Kumar, Hrishika Singh Chauhan, and Akhileshwar Namani. "RUNX1-Regulated Pathways and Biomarkers in Acute Myeloid Leukaemia." In IECC 2023. MDPI, 2023. http://dx.doi.org/10.3390/iecc2023-14279.

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