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Journal articles on the topic 'Acute Leukaemia'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Sarrou, Evgenia, Laura Richmond, Ruaidhrí J. Carmody, Brenda Gibson, and Karen Keeshan. "CRISPR Gene Editing of Murine Blood Stem and Progenitor Cells Induces MLL-AF9 Chromosomal Translocation and MLL-AF9 Leukaemogenesis." International Journal of Molecular Sciences 21, no. 12 (2020): 4266. http://dx.doi.org/10.3390/ijms21124266.

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Chromosomal rearrangements of the mixed lineage leukaemia (MLL, also known as KMT2A) gene on chromosome 11q23 are amongst the most common genetic abnormalities observed in human acute leukaemias. MLL rearrangements (MLLr) are the most common cytogenetic abnormalities in infant and childhood acute myeloid leukaemia (AML) and acute lymphocytic leukaemia (ALL) and do not normally acquire secondary mutations compared to other leukaemias. To model these leukaemias, we have used clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 gene editing to induce MLL-AF9 (MA9) chromosomal r

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2

Kuzmits, Rudolf, Paul Aiginger, Matthias M. Müller, Günter Steurer, and Werner Linkesch. "Assessment of the sensitivity of leukaemic cells to cytotoxic drugs by bioluminescence measurement of ATP in cultured cells." Clinical Science 71, no. 1 (1986): 81–88. http://dx.doi.org/10.1042/cs0710081.

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1. A short-term test in vitro is described, which can be used to detect resistance to cytostatic agents in leukaemic cells. Leukaemic cell suspensions were incubated with cytostatic agents and the resulting intracellular ATP concentrations were measured by a bioluminescence ATP assay. 2. There was a clear dose-effect relationship in acute leukaemia and chronic lymphocytic leukaemia cells for drugs used in the treatment of leukaemias. A good correlation was found between the ATP content of leukaemic cells and cell viability as determined by the trypan blue dye exclusion test. 3. Preliminary ind

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3

Siraj, Sayada, Chandra Rani Sarker, and Fahmiah Begum. "Relationship of Serum Uric Acid and Serum Creatinine Levels with Total Count of WBC in Acute Leukaemia." Haematology Journal of Bangladesh 8, no. 2 (2024): 56–62. https://doi.org/10.37545/haematoljbd2024133.

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Background: Leukaemia is uncontrolled proliferation of white blood cells caused by mutation of myelogenous or lymphogenous cells which are usually characterized by increased number of white blood cells in the blood. Leukaemia accounts for about four percent of all death from malignant disease. The incidence of acute leukaemia is about 10 per lac per year. Acute leukaemia can occur at any age. The cause of leukaemia is unknown in most patients. Serum uric acid and creatinine levels increased and positively correlated with total count of WBC in acute leukaemic patients. Objective: Objective of o

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Skarsgård, Lisa Stenman, Mattias K. Andersson, Marta Persson, et al. "Clinical and genomic features of adult and paediatric acute leukaemias with ophthalmic manifestations." BMJ Open Ophthalmology 4, no. 1 (2019): e000362. http://dx.doi.org/10.1136/bmjophth-2019-000362.

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ObjectiveTo describe the clinicopathological and genomic features of nine patients with primary and secondary orbital/ocular manifestations of leukaemia.MethodsAll orbital/ocular leukaemic specimens from 1980 to 2009 were collected from the Danish Register of Pathology. In six cases, medical records and formalin-fixed, paraffin-embedded blocks were available. Three cases from the Department of Pathology, Royal Liverpool University Hospital, were also included. Immunophenotypes and MYB oncoprotein expression were ascertained by immunohistochemistry. Genomic imbalances were analysed with compara

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5

Nurunnabi, Md, Mosammath Khadiza Mamdu, Ayesha Siddika, Farzana Zafreen, Md Abdul Wahab, and Shahana Shermin. "Morphological and Immunophenotypic Analysis in Diagnosis of Acute Leukaemia." Delta Medical College Journal 8, no. 1 (2022): 15–20. http://dx.doi.org/10.3329/dmcj.v8i1.58958.

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Background: Leukaemias are neoplastic proliferations of haematopoietic stem cells and form a major proportion of haematopoietic neoplasms that are diagnosed worldwide. Objective: To differentiate between morphological and immunophenotypic analysis in the diagnosis of acute leukemia. Materials and method: This cross sectional study was conducted in the department of Haematology, Armed Forces Institute of Pathology (AFIP), Dhaka, Bangladesh from January 2008 to December 2008. Total 50 patients were included after fulfilling inclusion and exclusion criteria. Results: The total o

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Ivanovic, Mirjana, Olivera Jovicic, Jelena Mandic, Dusko Bogetic, and Marcello Maddalone. "Oral manifestations of acute leukaemia." Srpski arhiv za celokupno lekarstvo 139, no. 1-2 (2011): 103–6. http://dx.doi.org/10.2298/sarh1102103i.

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Acute leukaemia is the most common form of chilhood cancer. The aim of this paper was to underline the importance of oral manifestations in children with acute leukaemia. The disease and its treatment can directly or indirectly affect oral health. Oral manifestations are gingival inflammation and enlargement. Leukaemic cells are capable of infiltrating the gingiva and the deeper periodontal tissues which leads to ulceration and infection of oral tissues. Gingival bleeding is a common sign in patients with leukaemia. Symptoms include local lymphadenopathy, mucous membrane Petechiae and ecchymos

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7

Hossain, Ireen, Niaz Abdur Rahman, and Syeed Mehbub Ul Kadir. "Severe Leukemic Retinopathy due to Acute Lymphoblastic leukemia." Community Based Medical Journal 13, no. 2 (2024): 277–81. http://dx.doi.org/10.3329/cbmj.v13i2.75322.

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Leukaemia is a myeloproliferative disorder which commonly affects the eye. The retina is most commonly affected by leukaemia. Both acute and chronic leukaemia can develop retinopathy. Patients can develop anaemia and thrombocytopenia. The ophthalmic features include white-centred retinal haemorrhages (Roth spot), cotton wool spots, macular haemorrhages and vitreous haemorrhages. CNS involvement through the optic nerve can cause papillo-oedema and cranial nerve palsy. Opportunistic infection can occur after chemotherapy. A young female patient was diagnosed with Acute Lymphoblastic leukaemia (A

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8

Jyoti, Ranjan Behera, Ranjan Mallick Manas, Kumar Tripathy Sandeep, Kumari Behera Pranati, and Behera Narendra. "Prevalance of Acute Leukemia in Children with Special Reference to Immunocytochemistry." International Journal of Pharmaceutical and Clinical Research 15, no. 11 (2023): 525–31. https://doi.org/10.5281/zenodo.11217522.

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<strong>Introduction: </strong>There are 50 to 200 cases of paediatric cancer for every million children worldwide. In developing nations, juvenile cancer accounts for 2% of all cancer cases and 0.5% of those in more industrialised nations. Children’s malignancies that are common worldwide include lymphoma and leukaemia. Childhood cancers most commonly diagnosed in industrialised and developing nations include leukaemias, which are the most prevalent kind, and lymphomas. It is estimated that leukaemia makes up one-third of childhood cancer cases, with acute lymphoblastic leukaemia (

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9

Budi, Luh Putu Rihayani, Ketut Ariawati, and Sianny Herawati. "NEONATAL ACUTE MYELOID LEUKAEMIA." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 19, no. 3 (2016): 211. http://dx.doi.org/10.24293/ijcpml.v19i3.417.

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Acute myeloid leukaemia (AML) is a. malignant, clonally disease that involves proliferation of blasts in bone marrow, blood, or other tissue. The blasts most often show myeloid or monocytic differentiation. The incidence of AML increases with age, but when neonatal leukaemia does occur, it is paradoxically AML rather than ALL. All the signs and symptoms that present on patient with AML are caused by the infiltration of the bone marrow with leukaemic cells and resulting failure of normal haematopoiesis. Without the normal haematopoietic elements, the patient is at risk for developing life-threa

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10

Dachi. "Acute Leukaemias in Bauchi State, Northeastern Nigeria: Pattern of Presentations and Clinical Entities." West Africa Journal of Medicine 39, no. 5 (2022): 497–500. http://dx.doi.org/10.55891/wajm.v39i5.122.

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Background: Acute leukaemias are very aggressive diseases that run a rapidly fatal course if not promptly diagnosed and appropriately treated. The clinical presentations range from bone marrow failure such as anaemia, neutropenia or thrombocytopenia to features of organ infiltrations such as lymphadenopathy, splenomegaly, etc, but presentations may be non-specific. Misdiagnosis is very common with delay in diagnosis and prompt treatment being the causes of high morbidity and mortality in acute leukaemias. This study aims to determine the pattern of presentation and various clinical entities of

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11

Sedick, Qanita, Sultan Alotaibi, Saeed Alshieban, Khalid Ben Naheet, and Ghaleb Elyamany. "Natural Killer Cell Lymphoblastic Leukaemia/Lymphoma: Case Report and Review of the Recent Literature." Case Reports in Oncology 10, no. 2 (2017): 588–95. http://dx.doi.org/10.1159/000477843.

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Natural killer (NK) cell lymphoblastic leukaemia/lymphoma is a rare haemopoietic tumour currently defined in the 2008 WHO classification under the category of acute leukaemias of ambiguous lineage. A diagnosis of this type of leukaemia is considered in cases expressing CD56 along with immature T-cell-associated markers such as CD2 and CD7 with absence of B-cell and myeloid markers; in addition, blastic plasmacytoid dendritic cell leukaemia should be excluded. Prior to 2008, these precursor NK cell lymphoblastic leukaemias/lymphomas were categorized as myeloid/NK cell acute leukaemia with a phe

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12

Sonal, Agarwal. "A Prospective Study on the Levels of Serum Uric acid & Serum lactate dehydrogenase in patients suffering from Leukaemia." International Journal of Pharmaceutical and Clinical Research 14, no. 10 (2022): 1040–46. https://doi.org/10.5281/zenodo.13309591.

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<strong>Background: </strong>An early diagnosis & timely treatment can play an important role in improving the prognosis & quality of life in leukaemic patients. Estimation of serum uric acid & serum lactate dehydrogenase in patients suffering from leukaemia have emerged as acceptable markers in monitoring the prognosis of such cases especially when treatment is ongoing. <strong>Aims:</strong> Estimation of Serum uric acid & lactate dehydrogenase levels in leukemic patients. <strong>Material & Method:</strong> The present study recruited 60 patients

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13

Onoja, AM, SA Otene, AT Onoja, et al. "Prevalence and Nature of Adult Hematological Malignancies Using Bone Marrow Aspiration Cytology in a Tertiary Health Facility: A Seven Year Retrospective Review." Western Journal of Medical and Biomedical Sciences 2, no. 1 (2021): 39–45. http://dx.doi.org/10.46912/wjmbs.39.

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Bone Marrow Aspiration (BMA) is a procedure that is often used to evaluate patients with haematological disorders including haematological malignancies (HMs) which account for about 6.5% of all cancers worldwide. There is paucity of data on the prevalence and pattern of HMs from BMA cytology in Nigeria. We carried out a retrospective review to determine the prevalence and distribution of HMs among adult patients who had BMA cytology at Benue State University Teaching Hospital (BSUTH) from June 2012 to July 2019. A total of 158 BMA reports extracted from the marrow and clinic medical records we

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14

Jeong, E., H. J. Park, J. Y. Lee, and B. K. Cho. "Leukaemic macrocheilia in acute myeloblastic leukaemia." British Journal of Dermatology 151, no. 5 (2004): 1102. http://dx.doi.org/10.1111/j.1365-2133.2004.06242.x.

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15

Yook, Hwa Jung, Joon Ho Son, Yeong Ho Kim, et al. "Leukaemia Cutis: Clinical Features and Outcomes of 56 Patients." Acta Dermato-Venereologica 102 (February 11, 2022): adv00647. http://dx.doi.org/10.2340/actadv.v102.1123.

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Leukaemia is a malignant neoplasm of the haematopoietic system. Cutaneous manifestations of leukaemia are called leukaemia cutis, and are regarded as a sign of poorer prognosis and shorter survival time. A single-institution retrospective review was performed of medical records of patients diagnosed with leukaemia cutis in the dermatology department of Seoul St Mary’s Hospital between January 2012 and April 2021. Fifty-six cases with cutaneous leukaemic involvement and underlying haematological malignancy were included (40 acute myelogenous leukaemia, 8 acute lymphoblastic leukaemia, 3 chronic

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16

Kuek, Vincent, Anastasia M. Hughes, Rishi S. Kotecha, and Laurence C. Cheung. "Therapeutic Targeting of the Leukaemia Microenvironment." International Journal of Molecular Sciences 22, no. 13 (2021): 6888. http://dx.doi.org/10.3390/ijms22136888.

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In recent decades, the conduct of uniform prospective clinical trials has led to improved remission rates and survival for patients with acute myeloid leukaemia and acute lymphoblastic leukaemia. However, high-risk patients continue to have inferior outcomes, where chemoresistance and relapse are common due to the survival mechanisms utilised by leukaemic cells. One such mechanism is through hijacking of the bone marrow microenvironment, where healthy haematopoietic machinery is transformed or remodelled into a hiding ground or “sanctuary” where leukaemic cells can escape chemotherapy-induced

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17

Janya, J., S. A. P. N. Samarasingha, D. Serasinghe, H. Jayawardhana, and W. W. L. A. Jayanaga. "Acute myeloid leukaemia masquerading as transverse myelitis." Journal of the Ruhunu Clinical Society 28, no. 1 (2023): 39–41. http://dx.doi.org/10.4038/jrcs.v28i1.137.

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Acute myeloid leukaemia (AML) is known to cause paraneoplastic transverse myelitis. However, the direct invasion or extramedullary compression of the spinal cord is rare unlike in the case of chronic lymphocytic leukaemia. We report the case of a young man presenting with transverse myelitis who was found to have leukaemic infiltrates on neuroimaging. The uniqueness of this being the first presentation of the patient with AML in the form of epidural infiltrates in the absence of peripheral blood count abnormalities. This highlights the importance of neuroimaging to delineate associated conditi

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18

Bhalla, Amit. "Clofarabine: a next-generation deoxyadenosine analogue." International Journal of Basic & Clinical Pharmacology 7, no. 5 (2018): 1048. http://dx.doi.org/10.18203/2319-2003.ijbcp20181660.

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Acute lymphoblastic leukaemia (ALL) is the most common of the paediatric leukaemias. It is estimated that the use of modern combination chemotherapy results in long-term remission in nearly 80% of children diagnosed with ALL. Despite therapy advances, approximately 20% of children with ALL, experience leukaemia relapse. Clofarabine (2-chloro-2’-fluoro-2’-deoxy-9-β-D-arabinofuranosyladenine) is a second-generation nucleoside analogue and is structurally related to fludarabine and cladribine which are widely used in the treatment of lymphoproliferative disorders. Clofarabine exhibits greater aff

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19

Gurusamy, Veeraraghavan, Ramya Panneerselvam, and Bharathi Vidhya Jayanthi. "Mixed phenotype acute leukaemia: a case report of an unusual presentation." International Journal of Research in Medical Sciences 5, no. 7 (2017): 3247. http://dx.doi.org/10.18203/2320-6012.ijrms20173024.

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Mixed phenotype acute leukaemias (MPALs), a varied group of disorders pose a diagnostic challenge to the physicians and pathologists alike. This rare subset of acute leukaemias are characterised by the presence of blasts which express markers of more than one lineage (B-lymphoid / T-lymphoid / Myeloid lineage), making the essentiality of immunophenotyping more pertinent. MPALs are included in the acute leukaemias of ambiguous lineage under the World health organization (WHO) classification of tumours of haematopoietic and lymphoid tissues. We describe here a case report of mixed phenotype acut

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20

Colovic, Natasa, Andrija Bogdanovic, Ana Vidovic, Maja Perunicic-Jovanovic, and Milica Colovic. "Granulocytic sarcoma of the femur in a patient with acute megakaryoblastic leukaemia." Srpski arhiv za celokupno lekarstvo 139, no. 11-12 (2011): 805–8. http://dx.doi.org/10.2298/sarh1112805c.

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Introduction. Granulocytic sarcoma, chloroma or myeloblastoma are observed in 3% to7% of acute myeloid leukaemia and represents localized tumour composed of collection of immature leukaemic cells. It appears most frequently in patients with M2, M4 and M5 subtypes of acute myeloid leukaemia Case Outline. A 58-year-old female presented with pain and oedema of the right upper limb in November 2009. After two months the patinet had fracture dislocation and numerous osteolytic lesions of the right femur. Immunohistochemistry of tumour biopsy showed megakaryoblastic granulocytic sarcoma which was CD

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Yao, Jie, Qing Huang, Xiao-Bing Zhang, and Wei-Ling Fu. "Promoter CpG methylation of oestrogen receptors in leukaemia." Bioscience Reports 29, no. 4 (2009): 211–16. http://dx.doi.org/10.1042/bsr20080140.

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Previous studies have suggested an important role of ERs (oestrogen receptors) in the pathogenesis of leukaemias. However, there is no information so far about the epigenetic characteristics of ERα isoforms and ERβ in leukaemias. In the present study, the mRNA expression and promoter CpG methylation of ERα isoforms (i.e. ERα-A, -B and -C) and ERβ in leukaemia cell lines were evaluated using RT–PCR (reverse transcription–PCR) and MSP (methylation-specific PCR) respectively. The methylation of ERs was further analysed in acute leukaemia patients by MSP and direct DNA sequencing. Although all ERα

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Ou, Ming-Che, Wen-Lee Hwang, and Chieh-Lin Teng. "Leukaemic pleural effusion in acute myeloid leukaemia." British Journal of Haematology 154, no. 6 (2011): 669. http://dx.doi.org/10.1111/j.1365-2141.2011.08722.x.

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23

Niazmand, Mohammad Javad, Matthew Speckert, and Donna Johnston. "Acute myeloid leukaemia presenting as proptosis in an infant." BMJ Case Reports 14, no. 12 (2021): e247506. http://dx.doi.org/10.1136/bcr-2021-247506.

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Paediatric patients with acute myeloid leukaemia (AML) often present with symptoms associated with the disruption of normal haematopoiesis and subsequent cellular deficiencies. Periosteal reactions are common in paediatric leukaemia, but typically manifest as a thin, laminated pattern along long bones. Aggressive periosteal reactions are much less frequently seen. Here, we report a case of paediatric AML initially presenting with proptosis and periorbital swelling caused by aggressive, sunburst periosteal reactions surrounding the sphenoid and zygomatic bones. This unique presentation emphasis

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Balboa, Pablo Lopez, Jack Bartram, Anna Martinez, and Gabriela Petrof. "P26 Leukaemia cutis as the first manifestation of acute myeloid leukaemia." British Journal of Dermatology 189, no. 3 (2023): e51-e51. http://dx.doi.org/10.1093/bjd/ljad259.034.

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Abstract Leukaemia is the most frequent malignancy of childhood, accounting for approximately 30% of all malignancies. Acute leukaemia may present in a variety of extramedullary manifestations, the commonest being leukaemia cutis (LC). LC is the infiltration of the epidermis, dermis or subcutis by neoplastic leukocytes with skin lesions preceding the development of leukaemia in the peripheral blood or bone marrow in just 2–3% of cases. A 6-month-old baby girl was reviewed due to multiple skin lesions which appeared on her left forearm 2 months previously, and spread widely, showing over 50 in

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25

Okikiolu, Jumoke, Richard Dillon, and Kavita Raj. "Acute leukaemia." Medicine 49, no. 5 (2021): 274–81. http://dx.doi.org/10.1016/j.mpmed.2021.02.004.

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Mehta, Milan M., Timothy S. Kemp, and Faddy Hardo. "Acute Leukaemia." InnovAiT: Education and inspiration for general practice 2, no. 8 (2009): 458–65. http://dx.doi.org/10.1093/innovait/inp113.

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A cute leukaemias are malignant disorders that arise from the clonal proliferation of a single haematopoietic stem cell. The morbidity and mortality associated with acute leukaemias are due to the effects of bone marrow failure which arises from the accumulation of abnormal blood cells in the bone marrow.

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Treleaven, Jennie, and Simon T. Meller. "Acute Leukaemia." Medicine 28, no. 3 (2000): 58–64. http://dx.doi.org/10.1383/medc.28.3.58.28367.

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Treleaven, Jennie, and Simon T. Meller. "Acute leukaemia." Medicine 32, no. 6 (2004): 65–69. http://dx.doi.org/10.1383/medc.32.6.65.36661.

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Raj, Kavita. "Acute leukaemia." Medicine 41, no. 5 (2013): 269–74. http://dx.doi.org/10.1016/j.mpmed.2013.03.011.

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Mwirigi, Anne, Richard Dillon, and Kavita Raj. "Acute leukaemia." Medicine 45, no. 5 (2017): 280–86. http://dx.doi.org/10.1016/j.mpmed.2017.02.010.

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31

Foa, Robin, Alessandro Cignetti, and Anna Guarini. "Acute Leukaemia." Clinical Immunotherapeutics 6, no. 3 (1996): 238–49. http://dx.doi.org/10.1007/bf03259522.

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Atwater, Susan K. "ACUTE PROMYELOCYTIC LEUKAEMIA DEVELOPING INTO ACUTE MYELOBLASTIC LEUKAEMIA." British Journal of Haematology 85, no. 2 (1993): 433. http://dx.doi.org/10.1111/j.1365-2141.1993.tb03199.x.

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Jubashi, Tohru. "ACUTE PROMYELOCYTIC LEUKAEMIA DEVELOPING INTO ACUTE MYELOBLASTIC LEUKAEMIA." British Journal of Haematology 85, no. 2 (1993): 433. http://dx.doi.org/10.1111/j.1365-2141.1993.tb03200.x.

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Stankovic, Tatjana, and Eliot Marston. "Molecular mechanisms involved in chemoresistance in paediatric acute lymphoblastic leukaemia." Srpski arhiv za celokupno lekarstvo 136, no. 3-4 (2008): 187–92. http://dx.doi.org/10.2298/sarh0804187s.

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Acute lymphoblastic leukaemia (ALL) is the most common paediatric cancer. Despite cure rates approaching 80%, resistance to treatment and disease relapse remain a significant clinical problem. Identification of the genes and biological pathways responsible for chemoresistance is therefore crucial for the design of novel therapeutic approaches aiming to improve patient survival. Mutations in the membrane transporter P-glycoprotein genes, genetic variations in drug-metabolising enzymes and defects in apoptotic pathways are mechanisms of chemoresistance common to a wide spectrum of cancers and al

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Erdemli, Haci Kemal, Bahattin Adam, and Nüket Bavbek. "Pyrimidine 5’Nucleotidase I and II Activities in Acute Leukaemias." Acta Medica (Hradec Kralove, Czech Republic) 47, no. 2 (2004): 129–31. http://dx.doi.org/10.14712/18059694.2018.78.

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Bacground and objective: Pyrimidine 5’nucleotidase I and II activities of peripheral mononuclear cells were studied to evaluate their role in diagnosis, assessment of therapy and follow up of remission in acute leukaemias. Design and methods: Blood samples were obtained from 40 untreated patients with acute lymphoblastic and myeloid leukaemia and 40 healthy controls, before the therapy and after remission. The correlation between the activity of the enzymes and the efficacy of therapy were established. The enzyme activities were measured by High-Performance Liquid Chromatography (HPLC), using

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Arruda, Walter Oleschko, María Belén Montú, Marcelo de Souza R. de Oliveira, and Ricardo Ramina. "Acute myeloid leukaemia induced by mitoxantrone: case report." Arquivos de Neuro-Psiquiatria 63, no. 2a (2005): 327–29. http://dx.doi.org/10.1590/s0004-282x2005000200024.

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Mitoxantrone (MX) is an immunosupressant drug used in secondarily progressive multiple sclerosis (SPMS) and in relapsing-remitting multiple sclerosis (RRMS). It has a leukemogenesis potential induced by cytogenetic abnormalities, though with a low incidence. Promyelocitic leukaemia (type M3) and other forms of acute myeloblastic leukaemias (M4 and M5) have been described in a few MS patients who received MX during their treatment. We describe a white female patient, 47 year-old, with SPMS (EDSS = 4) with 14 years of disease. She received MX during her disease and developed acute promyelocytic

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Gruszka, Alicja, Debora Valli, Cecilia Restelli, and Myriam Alcalay. "Adhesion Deregulation in Acute Myeloid Leukaemia." Cells 8, no. 1 (2019): 66. http://dx.doi.org/10.3390/cells8010066.

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Cell adhesion is a process through which cells interact with and attach to neighboring cells or matrix using specialized surface cell adhesion molecules (AMs). Adhesion plays an important role in normal haematopoiesis and in acute myeloid leukaemia (AML). AML blasts express many of the AMs identified on normal haematopoietic precursors. Differential expression of AMs between normal haematopoietic cells and leukaemic blasts has been documented to a variable extent, likely reflecting the heterogeneity of the disease. AMs govern a variety of processes within the bone marrow (BM), such as migratio

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W Aworanti, Oladapo, Foluke A Fasola, Taiwo R Kotila, John A Olaniyi, and Biobele J Brown. "Acute leukemia in sickle cell disease patients in a tertiary health facility in Nigeria: a case series." African Health Sciences 20, no. 3 (2020): 1304–12. http://dx.doi.org/10.4314/ahs.v20i3.36.

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Background and objectives: Sickle cell disease(SCD) is a disorder of red cells resulting from the co-inheritance of hae- moglobin S (HbS) with another abnormal haemoglobin. The diagnosis of acute leukaemia is uncommon in our patients with sickle cell disease more so the patients have high morbidity and mortality due to the sickling process.Acute leukemia is a malignant clonal disorder of haemopoietic precursor cells resulting in accumulation of immature blood cells in the bone marrow and blood.The objective of the case series was to highlight the challenges of diagnosis and management of SCD p

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Capelletti, Martina Maria, Orsola Montini, Emilio Ruini, Sarah Tettamanti, Angela Maria Savino, and Jolanda Sarno. "Unlocking the Heterogeneity in Acute Leukaemia: Dissection of Clonal Architecture and Metabolic Properties for Clinical Interventions." International Journal of Molecular Sciences 26, no. 1 (2024): 45. https://doi.org/10.3390/ijms26010045.

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Genetic studies of haematological cancers have pointed out the heterogeneity of leukaemia in its different subpopulations, with distinct mutations and characteristics, impacting the treatment response. Next-generation sequencing (NGS) and genome-wide analyses, as well as single-cell technologies, have offered unprecedented insights into the clonal heterogeneity within the same tumour. A key component of this heterogeneity that remains unexplored is the intracellular metabolome, a dynamic network that determines cell functions, signalling, epigenome regulation, immunity and inflammation. Unders

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Ho, Thi Quynh Anh, Peter Lee, and Lan Gao. "Temporal changes in the burden of leukaemia and lymphoma in the Australasia and Oceania regions, 2010–2019: an analysis of the Global Burden of Disease Study 2019." BMJ Open 14, no. 11 (2024): e084943. http://dx.doi.org/10.1136/bmjopen-2024-084943.

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ObjectivesLeukaemias and lymphomas are among the most prevalent and significant cancers in Australasia and Oceania. This study aims to examine the burden of leukaemias/lymphomas and its temporal trend in Australasia and Oceania from 2010 to 2019.DesignEpidemiological studyMethodsData from the Global Burden of Disease (GBD) 2019 were used to examine the burden of leukaemia/lymphoma key subtypes (acute lymphocytic leukaemia (ALL), acute myeloid leukaemia (AML), chronic lymphocytic leukaemia (CLL), chronic myeloid leukaemia (CML), Hodgkin-lymphoma (HL) and non-Hodgkin’s lymphoma (NHL)) by sex and

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Essa, Amr, Maryam Gbadamosi-Akindele, and Alan Lichtin. "Isolated CNS leukaemic relapse in acute myeloid leukaemia." BMJ Case Reports 12, no. 12 (2019): e233499. http://dx.doi.org/10.1136/bcr-2019-233499.

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Zuna, Jan, Tatiana Burjanivova, Zuzana Zemanova, et al. "MLL Translocation in a Multipotent Progenitor Causing Acute Lymphoblastic Leukaemia - Two-Step Model of the Disease." Blood 108, no. 11 (2006): 2295. http://dx.doi.org/10.1182/blood.v108.11.2295.2295.

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Abstract Leukaemias with MLL gene rearrangement are usually considered prognostically unfavourable and the clinical symptoms typically follow the translocation formation rapidly. MLL rearrangement is thus thought to be a major hit in leukaemogenesis that is either sufficient to cause the disease or it is a very strong and rapid inducer of the subsequent hit(s) required for the malignant transformation. We report an unusual presentation of secondary acute lymphoblastic leukaemia (sALL) with MLL rearrangement. Our patient was diagnosed originally with acute myeloid leukaemia (AML-M3) characteris

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Kacanski, Natasa, Nada Konstantinidis, Jovanka Kolarovic, Bojana Slavkovic, and Dragana Vujic. "Biphenotypic acute leukaemia: Case reports of two paediatric patients." Medical review 63, no. 11-12 (2010): 867–69. http://dx.doi.org/10.2298/mpns1012867k.

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Introduction. Biphenotypic acute leukaemia is an uncommon type of leukaemia whose blasts co-express myeloid and B-or T-lymphoid antigens. Case report. We describe two cases of paediatric patients with biphenotypic acute leukaemia. A four-year-old female patient was found to have myeloid and B-lymphoid associated antigens in the same blast cells. Cytogenetic analysis showed a Philadelphia (Ph) positivity t (9;22) (q34;q11) with rearrangements of M.bcr-Abl (p210). She was treated with combined acute myeloid leukaemia/acute lymphoblastic leukaemia induction therapy followed by autologous stem cel

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Balasubramanian, Priyavadhana, Prashant Ramteke, Saumyaranjan Mallick, Lalit Kumar, and Pranay Tanwar. "Diffuse Large B-Cell Lymphoma Relapsing in Leukaemic Phase Presenting as Acute Leukaemia." Clinical Medicine Insights: Blood Disorders 12 (January 2019): 1179545X1882116. http://dx.doi.org/10.1177/1179545x18821160.

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Diffuse large B-cell lymphoma (DLBCL) accounts for 30% to 40% of the newly diagnosed adult non-Hodgkin lymphomas, but rarely presents in leukaemic phase. Here in, we report a case of DLBCL presenting in leukaemic phase and masquerading as acute leukaemia. A 28-year-old woman presented to our outpatient department with complaints of fever for 1 week. Her peripheral blood smear showed 5% to 8% blasts. Bone marrow aspirate showed an infiltration by ~30% blasts. Flow cytometry and immunohistochemistry confirmed relapse of DLBCL. Also, patient’s poor response to therapeutic regimen for DLBCL prompt

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Ruiz-Aparicio, Paola Fernanda, and Jean-Paul Vernot. "Bone Marrow Aging and the Leukaemia-Induced Senescence of Mesenchymal Stem/Stromal Cells: Exploring Similarities." Journal of Personalized Medicine 12, no. 5 (2022): 716. http://dx.doi.org/10.3390/jpm12050716.

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Bone marrow aging is associated with multiple cellular dysfunctions, including perturbed haematopoiesis, the propensity to haematological transformation, and the maintenance of leukaemia. It has been shown that instructive signals from different leukemic cells are delivered to stromal cells to remodel the bone marrow into a supportive leukemic niche. In particular, cellular senescence, a physiological program with both beneficial and deleterious effects on the health of the organisms, may be responsible for the increased incidence of haematological malignancies in the elderly and for the survi

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Farhad, Muhammad Nurul, Salma Afrose, Md Sirajul Islam, and Gazi Yeasinul Islam. "Correlation of Bone Marrow Morphology and Immunophenotyping in Acute Leukaemia Patients." Haematology Journal of Bangladesh 4, no. 02 (2020): 30–32. http://dx.doi.org/10.37545/haematoljbd202061.

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Background: Acute leukaemia (AL) is a malignant disorder of the blood that is characterized by blocked or impaired differentiation of haemopoietic stem cells, resulting in abnormal accumulation of immature precursors and suppression of growth and maturation of cells in vivo. Objective: To find out correlation between morphological and immunophenotypic study of bone marrow among acute leukaemia patient. Methods/Procedure: This is a comparative cross sectional study of diagnosis of leukaemia by bone marrow study and immunophenotyping from bone marrow sample with bone marrow alone of suspected ca

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Thakur, Anantika, Rajni Kaushik, and Anchana Gulati. "Study of Patterns of Leukaemia in a Tertiary Care Hospital." International Journal of Research and Review 11, no. 4 (2024): 28–40. http://dx.doi.org/10.52403/ijrr.20240404.

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Introduction: Leukaemia arises from abnormal proliferation of hematopoietic or lymphoid cells, categorized as acute or chronic and originating from lymphoid, myeloid, or mixed lineages. Clinical manifestations result from leukemic cell proliferation and tissue infiltration. Objectives: This study aimed to determine the frequency and clinicopathological profile of leukaemia cases. Material and Methods: A three-year cross-sectional observational study was carried out in the Department of Pathology, Indira Gandhi Medical College, Shimla. Diagnosis of Leukaemia was based on complete blood count, p

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Jackson, Graham H., and Penelope R. A. Taylor. "Acute Myeloid Leukaemia." Drugs & Aging 19, no. 8 (2002): 571–81. http://dx.doi.org/10.2165/00002512-200219080-00003.

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Villela, Luis, and Javier Bolaños-Meade. "Acute Myeloid Leukaemia." Drugs 71, no. 12 (2011): 1537–50. http://dx.doi.org/10.2165/11593060-000000000-00000.

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Stevens, R. F. "Acute myeloid leukaemia." British Medical Bulletin 52, no. 4 (1996): 764–77. http://dx.doi.org/10.1093/oxfordjournals.bmb.a011581.

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