Relevant bibliographies by topics / Acute local drug-induced irritant action

Contents

  1. Journal articles
  2. Conference papers

Academic literature on the topic 'Acute local drug-induced irritant action'

Author: Grafiati
Published: 4 June 2025
Last updated: 1 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Acute local drug-induced irritant action.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Acute local drug-induced irritant action"

1

Sachuk, R. M., S. V. Zhyhalyuk, I. M. Lukyanik, M. S. Mandyhra, Ya S. Stravsky, and O. A. Katsaraba. "Research of acute toxicity, allergizing and local-irritative action of the veterinary drug “Yodozol”." Veterinary Medicine: inter-departmental subject scientific collection, no. 105 (August 7, 2019): 54–58. http://dx.doi.org/10.36016/vm-2019-105-10.

Full text
Abstract:
The purpose of the work was to determine, in experiments on rodents, the parameters of acute toxicity, allergenic and locally irritative effects of iodine-containing uterine drug for the treatment and prevention of intrauterine infections of animals. Materials and methods. Preclinical studies of acute toxicity of “Yodosol” containing iodine and potassium iodide were performed on 90 white mice, 30 white outbred rats and 6 rabbits. Clinical, pharmacotoxicological and statistical methods were used. Results of work. It has been found that at intragastric administration in experimental rats and mic
APA, Harvard, Vancouver, ISO, and other styles
2

Tetiana, Zhulai, Zupanets Igor, Shebeko Sergii, Zimin Stanislav, and Yampolska Kateryna. "Some aspects of enisamium iodide nasal spray safety: pre-clinical study results." ScienceRise: Medical Science, no. 2(35) (March 31, 2020): 35–40. https://doi.org/10.15587/2519-4798.2020.199597.

Full text
Abstract:
<strong>The aim.</strong>&nbsp;To substantiate the safety using of the new nasal spray with Enisamium Iodide via study results of acute local drug-induced irritant action of the test object single-dose to eyes and nasal cavity mucosa. <strong>Material and methods.</strong>&nbsp;Enisamium Iodide 10 mg/mL (nasal spray) was the test object. The reference drug was 0.9 % saline. Flemish Giant rabbits were used to induce the experiment (2 groups, 9 rabbits in each group). All study objects were administered in single-dose into the eye conjunctival sacs (0.01 mL) and nasal passages (0.1 mL) by instil
APA, Harvard, Vancouver, ISO, and other styles
3

Sachuk, R. M. "Determination of toxicity indicators and assessment of the sensibilizing action of the preparation for the external use ‘Ointment for wounds’." Journal for Veterinary Medicine, Biotechnology and Biosafety 5, no. 3 (2019): 22–26. http://dx.doi.org/10.36016/jvmbbs-2019-5-3-5.

Full text
Abstract:
The purpose of the work is a determination of toxicity and sensitizing effects of a new external preparation ‘Ointment for wounds’, based on the essential oils of Siberian pine, eucalypt, tea-tree, cedar, clove, and oil solution of chlorophyllite. The experimental study was performed on rats weighing 160–190 g, 2–3 months of age and mice weighing 18–21 g, 3 months of age. At the stages of preclinical study, it was determined acute and subacute effects of the drug, when administrated on the skin and directly into the stomach of experimental animals. The skin-irritant effect of the phytopreparat
APA, Harvard, Vancouver, ISO, and other styles
4

Patereha, I., A. Ostapiuk, V. Kushnir, et al. "SUB-ACUTE DERMAL TOXICITY OF SODIUM-CONTAINING DRUGS." Scientific and Technical Bulletin оf State Scientific Research Control Institute of Veterinary Medical Products and Fodder Additives аnd Institute of Animal Biology 24, no. 1 (2023): 127–32. http://dx.doi.org/10.36359/scivp.2023-24-1.18.

Full text
Abstract:
Drugs that have antimicrobial, anti-inflammatory and wound-healing effects deserve special attention, sodium-containing drugs are one of them, which is why they are used in veterinary medicine.&#x0D; The article presents the results of experimental studies to study the sub-acute toxicity of sodium-containing drugs: known – glycetinate 2%, its analogues – ovocid 2%, ovocid 3%, potassium-sodium 1.5% (Na / K, 1.5%).&#x0D; The study of sub-acute toxicity of drugs was carried out by applying drugs to the skin of animals. The experiment used white rats weighing 250-270 g. 4 groups of rats with 3 ani
APA, Harvard, Vancouver, ISO, and other styles
5

Shustov, E. B., and A. E. Kim. "Safety Profile of a New Dimethylaminoethanol Derivative by Oral Administration to Laboratory Animals." Journal Biomed 19, no. 3 (2023): 82–86. http://dx.doi.org/10.33647/2074-5982-19-3-82-86.

Full text
Abstract:
A new derivative of dimethylaminoethanol, butanedioic and trans-butenedioic acids (laboratory code ADK-17) was synthesized at the Department of Organic Chemistry (Professor I.P. Yakovlev is the Head of the Department) of St. Petersburg State Chemical and Pharmaceutical University (SPCPU). This is a promising compound planned for use as an oral dosage form. In this work, we aim to evaluate manifestations of the general and specific toxicity of the new drug. Laboratory animals (white mice, rats, rabbits, guinea pigs) were used as test systems for the preclinical safety study of the new compound.
APA, Harvard, Vancouver, ISO, and other styles
6

Golubeva, M. I., М. V. Bidevkina, I. A. Bobrineva, et al. "EXPERIMENTAL STUDY OF THE TOXICITY AND HAZARD OF QUETIAPINE FUMARATE." Toxicological Review, no. 6 (January 5, 2021): 54–58. http://dx.doi.org/10.36946/0869-7922-2020-6-54-58.

Full text
Abstract:
Quetiapine is a psychotropic drug, a dibenzothiazepine derivative and a representative of the class of neuroleptics (antipsychotic drugs) of a new subgroup – atypical antipsychotic drugs («second-generation antipsychotics»). Quetiapine fumarate belongs to the 3rd hazard class in terms of DL50 when administered in the stomach according to GOST 12.1.007-76 (DL50 1380-1680 mg/kg, mice and rats), has a local irritant effect: pronounced - on the mucous membrane of the eyes and moderately pronounced - on the skin. There are no signs of skin resorptive or cumulative effects of quetiapine fumarate. Wh
APA, Harvard, Vancouver, ISO, and other styles
7

Palagina, І. А., and M. Ya Kudria. "Assessment of toxicity and mechanism of the drug (camphoric acid derivative) effect on the organism." Environment & Health, no. 1 (102) (February 2022): 20–30. http://dx.doi.org/10.32402/dovkil2022.01.020.

Full text
Abstract:
The drugs, their active ingredients under conditions of manufacture and pharmaceutical waste at the ingress in the environment can be hazardous to the human health. The toxicological examination enables to predict the risk of their adverse effects on the organism with a determination of the prior criteria of hazard. Objectives: We defined the probable toxic effects and the mechanism of their formation under various conditions of the exposure of the original anti-diabetic drug based on a camphoric acid derivative (Diacamph - DCMPh) under various conditions of its exposure. Methods: The peculiar
APA, Harvard, Vancouver, ISO, and other styles
8

Peregonchiy, A. R., L. V. Cheskidova, I. V. Bryukhova, O. B. Pavlenko, and G. N. Bliznetsova. "STUDY OF THE IRRITANT EFFECT AND ANTI-INFLAMMATORY ACTIVITY OF THE OINTMENT UBEROSEPT." Transactions of the educational establishment “Vitebsk the Order of “the Badge of Honor” State Academy of Veterinary Medicine 60, no. 4 (2024): 50–54. https://doi.org/10.52368/2078-0109-2024-60-4-50-54.

Full text
Abstract:
The article presents the results of two series of experiments on studying the local irritant and anti-inflammatory action of a new complex ointment Uberosept. The studies of the anti-inflammatory activity of the drug were carried out on white rats using the zymosan-induced paw edema model. It has been found that the Uberosept ointment possesses pronounced anti-inflammatory properties, that are not inferior to the comparison drug (Hydrocortisone ointment). The experiments to assess the irritant effect of Uberosept were conducted on guinea pigs. The animals were applied the complex ointment at d
APA, Harvard, Vancouver, ISO, and other styles
9

Tejada, Miguel A., Angeles Montilla-García, Shane J. Cronin, et al. "Sigma-1 receptors control immune-driven peripheral opioid analgesia during inflammation in mice." Proceedings of the National Academy of Sciences 114, no. 31 (2017): 8396–401. http://dx.doi.org/10.1073/pnas.1620068114.

Full text
Abstract:
Sigma-1 antagonism potentiates the antinociceptive effects of opioid drugs, so sigma-1 receptors constitute a biological brake to opioid drug-induced analgesia. The pathophysiological role of this process is unknown. We aimed to investigate whether sigma-1 antagonism reduces inflammatory pain through the disinhibition of the endogenous opioidergic system in mice. The selective sigma-1 antagonists BD-1063 and S1RA abolished mechanical and thermal hyperalgesia in mice with carrageenan-induced acute (3 h) inflammation. Sigma-1–mediated antihyperalgesia was reversed by the opioid antagonists nalox
APA, Harvard, Vancouver, ISO, and other styles
10

Svistushkin, V. M., and K. V. Eremeeva. "Complex treatment of diseases of the nasal cavity and paranasal sinuses at the present time." Meditsinskiy sovet = Medical Council, no. 18 (December 1, 2021): 134–39. http://dx.doi.org/10.21518/2079-701x-2021-18-134-139.

Full text
Abstract:
The search for rational treatment of diseases of the nasal cavity and paranasal sinuses is due to the high incidence among the world's population. Despite the absolutely clear recommendations that would seem to greatly facilitate the choice and scope of therapy, it is extremely important to have a differentiated approach to each patient, depending on age, concomitant pathology, the nature of the course of the disease, the severity of clinical, primarily pain symptoms, and the presence of rhinogenic complications. Differential diagnosis of viral and bacterial acute rhinosinusitis (ARS) allows t
APA, Harvard, Vancouver, ISO, and other styles
More sources

Conference papers on the topic "Acute local drug-induced irritant action"

1

NIADA, R., R. Porta, R. Tettamanti, R. Pescador, M. Mantovani, and G. Prino. "DEFIBROTIDE IN EXPERIMENTAL MYOCARDIAL ISCHEMIA IN THE CAT: EFFECTS ON HEMODYNAMICS, ENERGY METABOLISM AND INFARCT SIZE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643152.

Full text
Abstract:
Defibrotide was able to prevent the hemodynamic and biochemical alterations caused by acute myocardial ischemia (AMI) induced by coronary occlusion in the cat when infused 3.5 h before and 5 h after left anterior descending coronary artery (LAD) occlusion. In the platelet perfused heart, Defibrotide was a selective stimulator of coronary vascular PGI^ but not of platelet thromboxane formation. The present study was designed both to investigate the effects of Defibrotide injected 30 min after the induction of acute myocardial ischemia (AMI) in the cat and to evaluate the ability of this drug to
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'Acute local drug-induced irritant action' for particular source types:
Journal articles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography