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Journal articles on the topic 'Acute local drug-induced irritant action'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Sachuk, R. M., S. V. Zhyhalyuk, I. M. Lukyanik, M. S. Mandyhra, Ya S. Stravsky, and O. A. Katsaraba. "Research of acute toxicity, allergizing and local-irritative action of the veterinary drug “Yodozol”." Veterinary Medicine: inter-departmental subject scientific collection, no. 105 (August 7, 2019): 54–58. http://dx.doi.org/10.36016/vm-2019-105-10.

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The purpose of the work was to determine, in experiments on rodents, the parameters of acute toxicity, allergenic and locally irritative effects of iodine-containing uterine drug for the treatment and prevention of intrauterine infections of animals. Materials and methods. Preclinical studies of acute toxicity of “Yodosol” containing iodine and potassium iodide were performed on 90 white mice, 30 white outbred rats and 6 rabbits. Clinical, pharmacotoxicological and statistical methods were used. Results of work. It has been found that at intragastric administration in experimental rats and mic

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2

Tetiana, Zhulai, Zupanets Igor, Shebeko Sergii, Zimin Stanislav, and Yampolska Kateryna. "Some aspects of enisamium iodide nasal spray safety: pre-clinical study results." ScienceRise: Medical Science, no. 2(35) (March 31, 2020): 35–40. https://doi.org/10.15587/2519-4798.2020.199597.

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<strong>The aim.</strong> To substantiate the safety using of the new nasal spray with Enisamium Iodide via study results of acute local drug-induced irritant action of the test object single-dose to eyes and nasal cavity mucosa. <strong>Material and methods.</strong> Enisamium Iodide 10 mg/mL (nasal spray) was the test object. The reference drug was 0.9 % saline. Flemish Giant rabbits were used to induce the experiment (2 groups, 9 rabbits in each group). All study objects were administered in single-dose into the eye conjunctival sacs (0.01 mL) and nasal passages (0.1 mL) by instil

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3

Sachuk, R. M. "Determination of toxicity indicators and assessment of the sensibilizing action of the preparation for the external use ‘Ointment for wounds’." Journal for Veterinary Medicine, Biotechnology and Biosafety 5, no. 3 (2019): 22–26. http://dx.doi.org/10.36016/jvmbbs-2019-5-3-5.

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The purpose of the work is a determination of toxicity and sensitizing effects of a new external preparation ‘Ointment for wounds’, based on the essential oils of Siberian pine, eucalypt, tea-tree, cedar, clove, and oil solution of chlorophyllite. The experimental study was performed on rats weighing 160–190 g, 2–3 months of age and mice weighing 18–21 g, 3 months of age. At the stages of preclinical study, it was determined acute and subacute effects of the drug, when administrated on the skin and directly into the stomach of experimental animals. The skin-irritant effect of the phytopreparat

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4

Patereha, I., A. Ostapiuk, V. Kushnir, et al. "SUB-ACUTE DERMAL TOXICITY OF SODIUM-CONTAINING DRUGS." Scientific and Technical Bulletin оf State Scientific Research Control Institute of Veterinary Medical Products and Fodder Additives аnd Institute of Animal Biology 24, no. 1 (2023): 127–32. http://dx.doi.org/10.36359/scivp.2023-24-1.18.

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Drugs that have antimicrobial, anti-inflammatory and wound-healing effects deserve special attention, sodium-containing drugs are one of them, which is why they are used in veterinary medicine. The article presents the results of experimental studies to study the sub-acute toxicity of sodium-containing drugs: known – glycetinate 2%, its analogues – ovocid 2%, ovocid 3%, potassium-sodium 1.5% (Na / K, 1.5%). The study of sub-acute toxicity of drugs was carried out by applying drugs to the skin of animals. The experiment used white rats weighing 250-270 g. 4 groups of rats with 3 ani

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5

Shustov, E. B., and A. E. Kim. "Safety Profile of a New Dimethylaminoethanol Derivative by Oral Administration to Laboratory Animals." Journal Biomed 19, no. 3 (2023): 82–86. http://dx.doi.org/10.33647/2074-5982-19-3-82-86.

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A new derivative of dimethylaminoethanol, butanedioic and trans-butenedioic acids (laboratory code ADK-17) was synthesized at the Department of Organic Chemistry (Professor I.P. Yakovlev is the Head of the Department) of St. Petersburg State Chemical and Pharmaceutical University (SPCPU). This is a promising compound planned for use as an oral dosage form. In this work, we aim to evaluate manifestations of the general and specific toxicity of the new drug. Laboratory animals (white mice, rats, rabbits, guinea pigs) were used as test systems for the preclinical safety study of the new compound.

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6

Golubeva, M. I., М. V. Bidevkina, I. A. Bobrineva, et al. "EXPERIMENTAL STUDY OF THE TOXICITY AND HAZARD OF QUETIAPINE FUMARATE." Toxicological Review, no. 6 (January 5, 2021): 54–58. http://dx.doi.org/10.36946/0869-7922-2020-6-54-58.

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Quetiapine is a psychotropic drug, a dibenzothiazepine derivative and a representative of the class of neuroleptics (antipsychotic drugs) of a new subgroup – atypical antipsychotic drugs («second-generation antipsychotics»). Quetiapine fumarate belongs to the 3rd hazard class in terms of DL50 when administered in the stomach according to GOST 12.1.007-76 (DL50 1380-1680 mg/kg, mice and rats), has a local irritant effect: pronounced - on the mucous membrane of the eyes and moderately pronounced - on the skin. There are no signs of skin resorptive or cumulative effects of quetiapine fumarate. Wh

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7

Palagina, І. А., and M. Ya Kudria. "Assessment of toxicity and mechanism of the drug (camphoric acid derivative) effect on the organism." Environment & Health, no. 1 (102) (February 2022): 20–30. http://dx.doi.org/10.32402/dovkil2022.01.020.

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The drugs, their active ingredients under conditions of manufacture and pharmaceutical waste at the ingress in the environment can be hazardous to the human health. The toxicological examination enables to predict the risk of their adverse effects on the organism with a determination of the prior criteria of hazard. Objectives: We defined the probable toxic effects and the mechanism of their formation under various conditions of the exposure of the original anti-diabetic drug based on a camphoric acid derivative (Diacamph - DCMPh) under various conditions of its exposure. Methods: The peculiar

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8

Peregonchiy, A. R., L. V. Cheskidova, I. V. Bryukhova, O. B. Pavlenko, and G. N. Bliznetsova. "STUDY OF THE IRRITANT EFFECT AND ANTI-INFLAMMATORY ACTIVITY OF THE OINTMENT UBEROSEPT." Transactions of the educational establishment “Vitebsk the Order of “the Badge of Honor” State Academy of Veterinary Medicine 60, no. 4 (2024): 50–54. https://doi.org/10.52368/2078-0109-2024-60-4-50-54.

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The article presents the results of two series of experiments on studying the local irritant and anti-inflammatory action of a new complex ointment Uberosept. The studies of the anti-inflammatory activity of the drug were carried out on white rats using the zymosan-induced paw edema model. It has been found that the Uberosept ointment possesses pronounced anti-inflammatory properties, that are not inferior to the comparison drug (Hydrocortisone ointment). The experiments to assess the irritant effect of Uberosept were conducted on guinea pigs. The animals were applied the complex ointment at d

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9

Tejada, Miguel A., Angeles Montilla-García, Shane J. Cronin, et al. "Sigma-1 receptors control immune-driven peripheral opioid analgesia during inflammation in mice." Proceedings of the National Academy of Sciences 114, no. 31 (2017): 8396–401. http://dx.doi.org/10.1073/pnas.1620068114.

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Sigma-1 antagonism potentiates the antinociceptive effects of opioid drugs, so sigma-1 receptors constitute a biological brake to opioid drug-induced analgesia. The pathophysiological role of this process is unknown. We aimed to investigate whether sigma-1 antagonism reduces inflammatory pain through the disinhibition of the endogenous opioidergic system in mice. The selective sigma-1 antagonists BD-1063 and S1RA abolished mechanical and thermal hyperalgesia in mice with carrageenan-induced acute (3 h) inflammation. Sigma-1–mediated antihyperalgesia was reversed by the opioid antagonists nalox

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10

Svistushkin, V. M., and K. V. Eremeeva. "Complex treatment of diseases of the nasal cavity and paranasal sinuses at the present time." Meditsinskiy sovet = Medical Council, no. 18 (December 1, 2021): 134–39. http://dx.doi.org/10.21518/2079-701x-2021-18-134-139.

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The search for rational treatment of diseases of the nasal cavity and paranasal sinuses is due to the high incidence among the world's population. Despite the absolutely clear recommendations that would seem to greatly facilitate the choice and scope of therapy, it is extremely important to have a differentiated approach to each patient, depending on age, concomitant pathology, the nature of the course of the disease, the severity of clinical, primarily pain symptoms, and the presence of rhinogenic complications. Differential diagnosis of viral and bacterial acute rhinosinusitis (ARS) allows t

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11

Agbaje, Esther Oluwatoyin, and Yewa Peace Doe. "Gastric and duodenal antiulcer effects of aqueous bark extract of Dialium guineense Wild. (Fabaceae) and the possible mechanisms in laboratory models." Journal of Phytopharmacology 4, no. 5 (2015): 268–75. http://dx.doi.org/10.31254/phyto.2015.4506.

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The plant Dialium guineense (DAG) has been claimed by local users, to be effective in the treatment of peptic ulcers, especially, when taken as an aqueous decoction. The present study assessed the antiulcer activity of the plant, as well as explored the possible mechanisms of action of the herbal drug, aside identifying some of the various phytoconstituents, which could be responsible for its antiulcer activity. Different ulcerogens (ethanol 99.9 %, indomethacin 50 mg/kg, cysteamine 400 mg/kg, glacial acetic acid) and the pylorus ligation-induced ulcers were used to induce acute and chronic ul

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12

Malek, Hala Abdel, and Dalia M. Saleh. "Cyclooxygenase-2 inhibitor celecoxib in a rat model of hindlimb ischemia reperfusion." Canadian Journal of Physiology and Pharmacology 87, no. 5 (2009): 353–59. http://dx.doi.org/10.1139/y09-019.

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Acute ischemia–reperfusion (IR) of the limbs initiates both local and systemic injuries by triggering a systemic inflammatory response. Cyclooxygenase-2 (COX-2), an endogenous inducible enzyme, rises in response to inflammation. The aim of this work is to investigate the role of celecoxib, a selective COX-2 inhibitor, in abrogating remote organ dysfunction after hindlimb IR in rats by comparing it with a standard hemorrheologic drug (pentoxifylline). Rats were divided into 4 groups (n = 6 each), group I (sham control, received saline and was kept under anaesthetic for 7 h). Group II (IR, subje

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13

Soja, Peter J., Niwat Taepavarapruk, Walton Pang, Brian E. Cairns, Shelly A. McErlane, and Miguel C. Fragoso. "Transmission through the Dorsal Spinocerebellar and Spinoreticular Tracts." Anesthesiology 97, no. 5 (2002): 1178–88. http://dx.doi.org/10.1097/00000542-200211000-00023.

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Background Most of what is known regarding the actions of injectable barbiturate anesthetics on the activity of lumbar sensory neurons arises from experiments performed in acute animal preparations that are exposed to invasive surgery and neural depression caused by coadministered inhalational anesthetics. Other parameters such as cortical synchronization and motor ouflow are typically not monitored, and, therefore, anesthetic actions on multiple cellular systems have not been quantitatively compared. Methods The activities of antidromically identified dorsal spinocerebellar and spinoreticular

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14

Hua, Susan. "Development of an Effective Topical Liposomal Formulation for Localized Analgesia and Antiinflammatory Actions in the Complete Freund’s Adjuvant Rodent Model of Acute Inflammatory Pain." Pain Physician 6;17, no. 6;12 (2014): E719—E735. http://dx.doi.org/10.36076/ppj.2014/17/e719.

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Background: Peripheral opioid receptor targeting has been well established as a novel target in clinical pain management for acute and chronic peripheral inflammatory pain. The physiochemical properties of the peripheral mu-opioid receptor agonist, loperamide HCl, limit the use of the free drug as an analgesic or anti-inflammatory agent, particularly for dermal delivery across intact skin. Objective: Our objective was to manufacture an effective topical formulation containing loperamide using liposomal delivery that would allow loperamide to produce analgesia and anti-inflammatory effects, by

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15

D.K., Salakhetdinov, and Sysuev B.B. "RESEARCH OF ACUTE TOXICITY OF FIXED DOSE COMBINATION TABLETS OF CITICOLINE AND MEMANTINE." "Medical & pharmaceutical journal "Pulse", July 30, 2021, 49–54. http://dx.doi.org/10.26787/nydha-2686-6838-2021-23-7-49-54.

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The development and study of the fixed dose combination tablets of citicoline and memantine is the relevant problem. The purpose of this study was the assessment of acute toxicity and local irritating effect of the new combined drug, the modified release tablets (citicoline 500 mg + memantine 10 mg). Material of research: fixed dose combination of modified release tablets (citicoline 500 mg + memantine 10 mg) (NovaMedica Innotech, Russia). The tested drug was administered intragastrically to males and females of half-plant outbred rats at a dose of 2000 mg/kg in the amount of active substances

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16

Shevchenko, O., D. Zasyekin, Yu Dobrozhan, S. Shuliak, V. Solomon, and V. Ishchenko. "RECLINICAL STUDIES OF THE DISINFECTIONS PREPARATION "IODOPOVIDONE" FOR THE NEEDS OF THE POULTRY FARMING OF UKRAINE." Sučasne ptahìvnictvo 2022, no. 7-8 (2022). http://dx.doi.org/10.31548/poultry2022.07-08.014.

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The results of preclinical tests of a polymeric complex of iodine enriched with citrates of microelements Zn, Fe, Cu, Co are reflected. "Iodopovedone" belongs to the category of drugs with negative microorganisms, viruses and pathogenic fungi. The experiment was carried out on outbred laboratory white rats and rabbits of the White Pannon breed, which were kept in the vivarium of the Faculty of Veterinary Medicine of the National University of Bioresources and Nature Management of Ukraine. The drug was developed for poultry farms of various forms of ownership as a disinfectant, including in the

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17

Han, Ziyi, Junjie Jin, Xiangfeng Chen, Yanfei He, and Hongxiang Sun. "Adjuvant activity of tubeimosides by mediating the local immune microenvironment." Frontiers in Immunology 14 (February 10, 2023). http://dx.doi.org/10.3389/fimmu.2023.1108244.

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Rhizoma Bolbostemmatis, the dry tuber of Bolbostemma paniculatum, has being used for the treatment of acute mastitis and tumors in traditional Chinese medicine. In this study, tubeimoside (TBM) I, II, and III from this drug were investigated for the adjuvant activities, structure-activity relationships (SAR), and mechanisms of action. Three TBMs significantly boosted the antigen-specific humoral and cellular immune responses and elicited both Th1/Th2 and Tc1/Tc2 responses towards ovalbumin (OVA) in mice. TBM I also remarkably facilitated mRNA and protein expression of various chemokines and cy

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18

Wang, Hua, Xiaowen Zhou, Chenbei Li, et al. "The emerging role of pyroptosis in pediatric cancers: from mechanism to therapy." Journal of Hematology & Oncology 15, no. 1 (2022). http://dx.doi.org/10.1186/s13045-022-01365-6.

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AbstractPediatric cancers are the driving cause of death for children and adolescents. Due to safety requirements and considerations, treatment strategies and drugs for pediatric cancers have been so far scarcely studied. It is well known that tumor cells tend to progressively evade cell death pathways, which is known as apoptosis resistance, one of the hallmarks of cancer, dominating tumor drug resistance. Recently, treatments targeting nonapoptotic cell death have drawn great attention. Pyroptosis, a newly specialized form of cell death, acts as a critical physiological regulator in inflamma

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19

Fleischer, Michael, Rebecca D. Szepanowski, Valeria Pesara, et al. "Direct neuronal protection by the protease‐activated receptor PAR4 antagonist ML354 after experimental stroke in mice." British Journal of Pharmacology, May 17, 2024. http://dx.doi.org/10.1111/bph.16415.

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Background and PurposeThrombo‐inflammation is a key feature of stroke pathophysiology and provides multiple candidate drug targets. Thrombin exerts coagulation‐independent actions via protease‐activated receptors (PAR), of which PAR1 has been implicated in stroke‐associated neuroinflammation. The role of PAR4 in this context is less clear. This study examined if the selective PAR4 antagonist ML354 provides neuroprotection in experimental stroke and explored the underlying mechanisms.Experimental ApproachMouse primary cortical neurons were exposed to oxygen–glucose deprivation (OGD) and simulat

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20

., Shivam, and Asheesh Kumar Gupta. "Neuroprotective Effects of Isolated Mangiferin from Swertia chirayita Leaves Regulating Oxidative Pathway on Streptozotocin-Induced Diabetic Neuropathy in Experimental Rats." Central Nervous System Agents in Medicinal Chemistry 24 (January 16, 2024). http://dx.doi.org/10.2174/0118715249255977231213053039.

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Background: Oxidative stress has an important role in the pathogenesis and development of diabetic peripheral neuropathy (DPN), the most common and debilitating complication of diabetes mellitus. Swertia chirayita is a rich source of phenolic constituents and has hypoglycemic, anti-inflammatory, and antioxidant properties. Aims: This study was performed to evaluate the neuroprotective effect in diabetes by enhancing antioxidant defense against oxidative stress, which exhibits a neuroprotective effect in streptozotocin- induced diabetic rats. objective: Our objectives attempt to explain the the

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21

Дуллах, Арам, І. О. Власенко, Г. М. Войтенко та Л. Л. Давтян. "ВИВЧЕННЯ ПРОТИЗАПАЛЬНОЇ АКТИВНОСТІ ОПРАЦЬОВАНОГО КРЕМУ БЕТАКАРБОКЛОМЕТ". Фармацевтичний часопис, № 3 (8 жовтня 2015). http://dx.doi.org/10.11603/2312-0967.2015.3.4941.

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<p><strong>STUDY OF ANTIINFLAMMATORY ACTIVITY OF FORMULTATED CREAM BETAKARBOKLOMET</strong></p><p><strong>Aram Dullah, </strong><strong>I</strong><strong>.</strong><strong>O</strong><strong>.Vlasenko, </strong><strong>G</strong><strong>.</strong><strong>M</strong><strong>. </strong><strong>Voytenko</strong><strong>,</strong> <strong>L.L. Davtyan </strong></p><p><em>Shupik</em><em> </em>&

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22

"Final Report on the Safety Assessment of Capsicum Annuum Extract, Capsicum Annuum Fruit Extract, Capsicum Annuum Resin, Capsicum Annuum Fruit Powder, Capsicum Frutescens Fruit, Capsicum Frutescens Fruit Extract, Capsicum Frutescens Resin, and Capsaicin1." International Journal of Toxicology 26, no. 1_suppl (2007): 3–106. http://dx.doi.org/10.1080/10915810601163939.

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Capsicum-derived ingredients function as skin-conditioning agents—miscellaneous, external analgesics, flavoring agents, or fragrance components in cosmetics. These ingredients are used in 19 cosmetic products at concentrations as high as 5%. Cosmetic-grade material may be extracted using hexane, ethanol, or vegetable oil and contain the full range of phytocompounds that are found in the Capsicum annuum or Capsicum frutescens plant (aka red chiles), including Capsaicin. Aflatoxin and N -nitroso compounds ( N -nitroso dimethylamine and N -nitrosopyrrolidine) have been detected as contaminants. T

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23

Dolomatov, S.I., та W. Zukow. "Эпигенетика почек = Kidneys epigenetics". 7 липня 2019. https://doi.org/10.5281/zenodo.3270754.

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<strong>Dolomatov S.I., Zukow W. </strong><strong>Эпигенетика почек</strong><strong> = Kidney</strong><strong>s</strong><strong> epigenetics</strong><strong>. </strong><strong>RSW. Radom,</strong><strong> 144 </strong><strong>p. ISBN </strong><strong>9780359774524</strong><strong>.</strong><strong> DOI </strong><strong>http://dx.doi.org/10.5281/zenodo.3270699</strong><strong> PBN Poland </strong><strong>https://pbn.nauka.gov.pl/sedno-webapp/works/917606</strong>           <strong>Radomska Szkoła Wyższa w Radomiu, Radom, Poland</strong>         &nbsp

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