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Journal articles on the topic 'Acute oral toxicity'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Rao, K. S. "Acute Oral Toxicity." Biology, Engineering, Medicine and Science Reports 4, no. 2 (2019): 39–41. http://dx.doi.org/10.5530/bems.4.2.10.

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Walum, Erik. "Acute Oral Toxicity." Environmental Health Perspectives 106 (April 1998): 497. http://dx.doi.org/10.2307/3433801.

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Walum, E. "Acute oral toxicity." Environmental Health Perspectives 106, suppl 2 (1998): 497–503. http://dx.doi.org/10.1289/ehp.98106497.

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4

Pandhare, Ramdas Bhanudas. "Assessment of Acute and 28-Day Sub-Acute Oral Toxicity of a Polyherbal Formulation in Rats." International Journal of Pharmacognosy & Chinese Medicine 4, no. 1 (2020): 1–7. http://dx.doi.org/10.23880/ipcm-16000200.

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Purpose: Most of these studies are conducted to assess the degree to which substances are toxic (poisonous) for humans, animals or the environment, to investigate the mechanism of toxic chemicals, or to develop new or improved tests for specific types of chemically induced effects. The present study was designed to evaluate the acute and 28 days repeated oral toxicity study of Polyherbal formulation according to OECD guidelines. Materials and Methods: In acute oral toxicity study, Herbal mixture was administered at 2000mg/kg orally and animals were observed for toxic signs at 30 min, 1, 2 and

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Korte, D. W., L. W. Brown, E. W. Morgan, et al. "Acute Oral Toxicity of Guanidine Nitrate." Journal of the American College of Toxicology 12, no. 6 (1993): 594–95. http://dx.doi.org/10.3109/10915819309142030.

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Korte, D. W., E. W. Morgan, G. F. S. Hiatt, and G. Reddy. "Acute Oral Toxicity of Guanidine Hydrochloride." Journal of the American College of Toxicology 12, no. 6 (1993): 598–99. http://dx.doi.org/10.3109/10915819309142032.

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Korte, D. W., L. W. Brown, E. W. Morgan, et al. "Acute Oral Toxicity of Guanidine Nitrate." Journal of the American College of Toxicology 12, no. 6 (1993): 594–95. http://dx.doi.org/10.1177/109158189301200624.

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Korte, D. W., E. W. Morgan, G. F. S. Hiatt, and G. Reddy. "Acute Oral Toxicity of Guanidine Hydrochloride." Journal of the American College of Toxicology 12, no. 6 (1993): 598–99. http://dx.doi.org/10.1177/109158189301200626.

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Henderson, Rayetta G., Jennifer Durando, Adriana R. Oller, Daniel J. Merkel, Palma Ann Marone, and Hudson K. Bates. "Acute oral toxicity of nickel compounds." Regulatory Toxicology and Pharmacology 62, no. 3 (2012): 425–32. http://dx.doi.org/10.1016/j.yrtph.2012.02.002.

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Rameshwar, Gothe Shivani, Pawade Uday Venkatrao, Nikam Ashwin Vithalrao, and Anjankar Meghsham Pramodrao. "OECD GUIDELINES FOR ACUTE ORAL TOXICITY STUDIES: AN OVERVIEW." International Journal of Research in Ayurveda and Pharmacy 14, no. 4 (2023): 137–40. http://dx.doi.org/10.7897/2277-4343.1404130.

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The OECD Guidelines for testing chemicals provide a unique method for assessing the potential impact of chemicals on human health and the environment. These are divided into five sections. Oral toxicity studies are mentioned in the fourth section, i.e. Health Effects. This section cites the guidelines for acute, sub-acute, sub-chronic and chronic oral toxicity studies. Acute oral toxicity refers to those adverse effects of oral administration of a single dose or multiple doses given within 24 hours. OECD guidelines for Acute oral toxicity include 420 (Fixed Dose Procedure), 423 (Acute Toxic Cl

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Kadam, Asha Bhausaheb. "Evaluation of Synergistic Formulation Extract of Traditional Contraceptive Plants for Acute Oral Toxicity." Advances in Clinical Toxicology 8, no. 4 (2023): 1–8. http://dx.doi.org/10.23880/act-16000284.

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In folk medicine, certain plants are used to prevent pregnancy. The purpose of the study was to evaluate the synergistic formulation of conventional contraceptive herb’s acute toxicity. Acute toxicity refers to a negative change that happens right away after exposure to a drug. Using OECD-423 recommendations, the acute toxicity of crude oil and its aqueous extract was assessed after oral administration to female mice. 2000mg/kg of a high extract was provided as a single dosage, and the effects on mortality, behavioural pattern, and spontaneous movement (Locomotor activity) of the body were ass

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12

Oluwasegun, Adedokun, Ume Ogochukwu, Odunola Mansurat, et al. "Evaluation of toxicological profile of methanol leaf extract of Waltheria indica (Sterculiaceae)." GSC Biological and Pharmaceutical Sciences 17, no. 2 (2021): 034–43. https://doi.org/10.5281/zenodo.5720153.

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<em>Waltheria indica</em> has been claimed to be used in managing several diseases in traditional medicine, although substantial scientific data are not available as regards its safety despite its pronounced efficacy in management of some ailments. Therefore, methanol leaf extract of <em>W. indica </em>was evaluated for its effects on some toxicological parameters using experimental animals. However, acute and sub-acute toxicity were carried out using experimental animals as described by standard methods. Absence of death reported after 24 hours of single oral administration of&

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13

Sri Nurestri, AM, SK Sinniah, KH Kim, AW Norhanom, and KS Sim. "Acute oral toxicity ofPereskia bleoandPereskia grandifoliain mice." Pharmacognosy Magazine 6, no. 21 (2010): 67. http://dx.doi.org/10.4103/0973-1296.59969.

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14

Kinkead, E. R., R. E. Wolfe, and S. A. Salins. "Acute Oral and Dermal Toxicity of Quadricyclane." Journal of the American College of Toxicology 12, no. 6 (1993): 634. http://dx.doi.org/10.3109/10915819309142061.

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15

Choi, Hye-Kyung, Hang-Sik Roh, Ja-Young Jeong, and Hun-Yong Ha. "Acute Oral Toxicity of Atractylodes macrocepala KOIDZ." Korean Journal of Plant Resources 27, no. 1 (2014): 11–21. http://dx.doi.org/10.7732/kjpr.2014.27.1.011.

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Kinkead, E. R., R. E. Wolfe, and S. A. Salins. "Acute Oral and Dermal Toxicity of Quadricyclane." Journal of the American College of Toxicology 12, no. 6 (1993): 634. http://dx.doi.org/10.1177/109158189301200655.

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Jestoi, M., M. Jonsson, P. Koivisto, et al. "Acute oral toxicity of fusarium-mycotoxin moniliformin." Toxicology Letters 196 (July 2010): S333. http://dx.doi.org/10.1016/j.toxlet.2010.03.1054.

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18

Tung, Tran Thanh, Dau Thuy Duong, Pham Thi Thuy Minh, Nguyen Thu Hien, and Dinh Thi Thu Hang. "Evaluation of acute and subchronic toxicities of “Phuong Dong Dai Trang” tablets in experimental animals." Tạp chí Nghiên cứu Y học 141, no. 5 (2021): 29–38. http://dx.doi.org/10.52852/tcncyh.v141i5.210.

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The study aimed to evaluate the acute and subchronic toxicities of “Phuong Dong Dai Trang” tablets through oral administration using experimental animal models. Acute toxicity in Swiss mice was determined using the Litchfield Wilcoxon method. The subchronic toxicity in Wistar rats was evaluated according to WHO and OECD’s recommendation with oral doses of 4.68 g/kg/day (equivalent to recommended human dose) and 14.04 g/kg/day (3 times the recommended human dose) for 4 consecutive weeks. In terms of acute toxicity, “Phuong Dong Dai Trang” tablets did not express acute toxicity in mice at the hi

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Farruggia, Frank T., Kristina Garber, Christine Hartless, et al. "A retrospective analysis of honey bee (Apis mellifera) pesticide toxicity data." PLOS ONE 17, no. 4 (2022): e0265962. http://dx.doi.org/10.1371/journal.pone.0265962.

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Current USEPA ecological risk assessments for pesticide registration include a determination of potential risks to bees. Toxicity data are submitted to support these assessments and the USEPA maintains a large database containing acute and chronic toxicity data on adult and larval honey bees (Apis mellifera), which USEPA considers a surrogate for Apis and non-Apis bees. We compared these toxicity data to explore possible trends. This analysis indicated a significant correlation between acute contact and oral median lethal dose (LD50) values for adult honey bees (ρ = 0.74, p <0.0001). Using

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Tung, Tran Thanh, Nguyen Thanh Binh, and Dang Thi Thu Hien. "Acute and sub-chronic toxicities of phatra tricholes capsule in experimental animals." Tạp chí Nghiên cứu Y học 177, no. 4E14 (2024): 115–23. http://dx.doi.org/10.52852/tcncyh.v177i4e14.2281.

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Phatra Tricholes capsule is a multiplant production planned for dyslipidemia patients. Herein, we assessed the potential toxicity of Phatra Tricholes, applying the protocol of acute and sub-chronic oral administration in experimental animal models. According to the WHO guidelines, the acute toxicity study was conducted on Swiss mice. Sub-chronic toxicity studies were conducted in Wistar rats, and oral administration was done at 0.11 and 0.33 g/kg for 30 consecutive days. As a result, Phatra Tricholes capsule used for mice at the highest dose (19.58 g/kg b.w) did not express acute toxicity in m

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21

Liu, Chia-Hung, Hsien-Chun Chiu, Hsiang-Ling Sung, Jyun-Yi Yeh, Kevin C. W. Wu, and Shing-Hwa Liu. "Acute oral toxicity and repeated dose 28-day oral toxicity studies of MIL-101 nanoparticles." Regulatory Toxicology and Pharmacology 107 (October 2019): 104426. http://dx.doi.org/10.1016/j.yrtph.2019.104426.

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22

Banjare, Purusottam, Jagadish Singh, and Partha Pratim Roy. "QSTR Analysis of Acute Rat Oral Toxicity of Amide Pesticides." International Journal of Quantitative Structure-Property Relationships 5, no. 2 (2020): 73–99. http://dx.doi.org/10.4018/ijqspr.2020040103.

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The rodent acute toxicity is gaining much attention in the ecotoxicological assessment of chemicals. Among the available amide pesticides, the majority of compounds are lacking the experimental toxicity values of rat oral toxicity. In order to explore the structural alerts for toxicity and to fill the toxicity data gap through in silico studies, a series of statistically robust local quantitative structure-toxicity relationship (QSTR) models were developed for the prediction of acute oral toxicity of amide pesticides on rat following OECD principles. The mechanistic interpretation indicated ty

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23

Zhou, Zhi Xiang, and Yang Hua Liu. "Quantitative Structure-Toxicity Relationship for Predicting Acute Toxicity of Alkylbenzenes." Applied Mechanics and Materials 665 (October 2014): 571–74. http://dx.doi.org/10.4028/www.scientific.net/amm.665.571.

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Acute toxicity is an important toxicological endpoint which poses a great concern being the major determinants of health problem, a quantitative structure toxicity relationship (QSTR) study was performed for the prediction of the acute toxicity of alkylbenzenes. The molecular descriptors of alkylbenzenes have been calculated with semi-empirical AM1 and E-dragon methods, and QSTR model for mice via the oral LD50 model of alkylbenzenes was developed using multiple linear regression (MLR) analysis.

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24

Gebrehiwot, Sibhatu. "Evaluation of acute and sub-acute toxicity of hydro-alcoholic extract of Capparis tomentosa Lam. in swiss albino mice." Journal of Scientific and Innovative Research 7, no. 3 (2018): 60–63. http://dx.doi.org/10.31254/jsir.2018.7301.

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The aim of the present study was to evaluate the toxicity of crude hydro-alcholic extract of Capparis tomentosa in Swiss albino mice. In studying the toxicity, Organization for Economic Cooperation and Development (OECD) guidelines was used. Experimental animals (mice), five mice in each, were grouped into four groups; three experimental groups and one negative control. In studying the acute toxicity, up to 5000 mg/kg crude hydro-alcholic plant extract was given orally using standard intragastric oral gavage. For acute toxicity a single dose was given and gross behavioral change such as inflex

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25

Cha, Nguyen Thi, Ho Phu Ha, Nguyen Tien Thanh, et al. "In vivo assessment of acute and subchronic toxicity of Nanochitin in experimental animals." Tạp chí Nghiên cứu Y học 190, no. 5E16 (2025): 137–44. https://doi.org/10.52852/tcncyh.v190i5e16.3508.

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This study aimed to evaluate the safety of Nanochitin through oral administration in experimental animals. The acute toxicity was determined in mice at ascending doses and the subchronic toxicity was evaluated in rats with oral doses of 15.6 mg/kg b.w/day and 46.8 mg/kg b.w/day for 30 days. As a result, in the course of the acute toxicity test, Nanochitin at the highest dose of 750 mg/kg did not express acute toxicity in mice. Along with the subchronic toxicity test, Nanochitin had no deleterious effect on hematological parameters, hepato-renal functions, macroscopic and microscopic images of

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26

Li, Meng, Rui Han, Juan Li, Wenhui Wu, and Jianqi Gu. "Research Progress in Acute Oral Toxicity Testing Methods." International Journal of Biology and Life Sciences 6, no. 1 (2024): 19–22. http://dx.doi.org/10.54097/nv9van65.

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Acute oral toxicity is the first phase of safety toxicological evaluation, with the median lethal dose (LD50) being the most commonly used assessment parameter. This paper aims to summarize and compare conventional methods for determining LD50 and alternative approaches, along with their respective advantages and disadvantages, to provide options for further toxicological studies. Alternative tests, which do not require the precise determination of LD50 values, minimize animal mortality to the greatest extent and reduce the waste of human and material resources, making them worthy of promotion

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27

van den Heuvel, M. J., A. D. Dayan, and R. O. Shillaker. "Evaluation of the BTS Approach to the Testing of Substances and Preparations for their Acute Toxicity." Human Toxicology 6, no. 4 (1987): 279–91. http://dx.doi.org/10.1177/096032718700600405.

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This study has shown that the new approach to acute oral toxicity testing proposed by the British Toxicology Society 1 provides the information on the toxic effects of materials necessary for human risk assessment, 2 can be used to rank materials for regulatory purposes on the basis of their acute toxicity, 3 provides advantages for animal welfare by requiring the use of fewer animals than conventional acute oral toxicity tests and by subjecting those animals used to less chance of experiencing pain or distress.

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Hoffmann, Peter, Lori Martin, Michael Keselica, et al. "Acute Toxicity of Vildagliptin." Toxicologic Pathology 45, no. 1 (2016): 76–83. http://dx.doi.org/10.1177/0192623316672944.

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This article describes acute toxicity data in cynomolgus monkeys following oral treatment with vildagliptin, a dipeptidyl peptidase-4 inhibitor. Acute toxicity symptoms in cynomolgus monkeys include edema formation of the extremities, tails, and face associated with skeletal muscle necrosis, and elevations of lactate dehydrogenase, creatine kinase, alanine transaminase, and aspartate aminotransferase activities in the serum; hypothermia; hypotension; tachycardia; moribundity; and death in a few isolated instances. In surviving animals, symptoms were reversible even if treatment was continued.

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29

Nguyen, Anh-Ngoc, Ngan-Tuyet Duong, Khanh-Duy Dang, Nha-Thao Ngoc Nguyen, and Ngoc-Van Thi Nguyen. "Evaluation of the acute and sub-acute toxicity of the standardized extract of Avicennia officinalis L. in mice." Journal of Multidisciplinary Sciences 6, no. 1 (2024): 32–39. http://dx.doi.org/10.33888/jms.2024.615.

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Avicennia officinalis L. (AOL) has shown promise for its anti-inflammatory, anti-cancer, and antioxidant properties. However, there is no research on the toxicity of this plant in Vietnam. The acute and sub-acute toxicology study proved that AOL leaf extracts are practically non-toxic in normal mice. Acute toxicity assessment was conducted with single oral doses of AOL extract (2500, 3100, 4100, and 5000 mg/kg). In sub-acute toxicity, mice were administered daily oral doses of AOL extract (200 and 400 mg/kg) for 28 days. Blood was collected from the heart, liver, and kidneys for further analys

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30

Kumar CN, Santhosh, Shridhar N B, Satyanarayana M L, and Ansar Kamran C. "Toxicity studies of Sapindus laurifolius methanolic leaf extract in Wistar rats." Journal of Laboratory Animal Science 2, no. 1 (2024): 32–37. https://doi.org/10.48165/jlas.2019.2.1.6.

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Studies were aimed to evaluate the phytochemical composition of the Sapindus laurifolius leaves and toxicological effect of the Sapindus laurifolius leaf extract using Wistar albino rats as a model animal. The phytochemical analysis was performed using High Performance Thin Layer Chromatography (HPTLC). In toxicity studies, the acute oral toxicity study was conducted as per the guidelines of Organization for Economic Co-operation and Development (OECD 423 Acute Toxic Class Method) for testing of chemicals. In repeated dose 28-day oral toxicity study (OECD 407), leaf extract administered at the

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31

Yang, Hyejin, Minseok Yoon, Jiyoung Kim, and Suengmok Cho. "Acute Oral Toxicity of Phlorotannins in Beagle Dogs." Korean Journal of Fisheries and Aquatic Sciences 47, no. 4 (2014): 356–62. http://dx.doi.org/10.5657/kfas.2014.0356.

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32

Lee, Hyeong-Seon. "Acute Oral Toxicity ofSalicornia herbaceaL. Extract in Mice." Biomedical Science Letters 22, no. 2 (2016): 46–52. http://dx.doi.org/10.15616/bsl.2016.22.2.46.

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33

Todić, Maida, Sanela Bakić, Irfan Zulić, et al. "Oral acute toxicity of HEPALIP FORTE in rats." Bosnian Journal of Basic Medical Sciences 3, no. 4 (2003): 30–36. http://dx.doi.org/10.17305/bjbms.2003.3489.

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he main active component of preparation HEPALIP FORTE is EPL--essential phospholipids. Their chemical structure corresponds to that of endogen phospholipids, but they have functional superiority because of the content of unsaturated fatty acids. Essential phospholipids in combination with the vitamins have been used in the treatment of liver diseases, dyslipoproteinaemias and intoxications with consequent liver failure. Acute toxicity study on HEPALIP FORTE was performed on Wistar rats. The main aim of toxicology studies for the drug registration process is evaluation of the toxic potential an

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34

Krošnjar, Sanja, Maida Todić, Sanela Bakić, Begler Begović, Irfan Zulić, and Midhat Vehabović. "Oral Acute Toxicity of Polyenylphosphatidylcholine (PPC) in Rats." Bosnian Journal of Basic Medical Sciences 5, no. 3 (2005): 63–68. http://dx.doi.org/10.17305/bjbms.2005.3273.

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Endogen phospholipids play a major role in determining the structure and nature of cell membranes. A deficiency of phospholipids in cellular membranes makes it almost impossible for the cell membrane to perform its function as a selective barrier between what passes in and out of the cell. Polyenylphosphatidylcholine chemical structure corresponds to that of endogen phospholipids, but it possesses functional superiority because of its content of unsaturated fatty acids. Polyenylphosphatidylcholine integrates in the cell membrane and organelle systems while becoming their constitutive elements.

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35

Chengelis, C., S. Gad, J. Andress, S. Tegtmeyer, and J. Siglin. "Acute Oral and Dermal Toxicity of SC-39026." Journal of the American College of Toxicology 1, no. 3 (1992): 155–56. http://dx.doi.org/10.1177/109158189200100302.

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36

Sosa, S., G. Del Favero, M. De Bortoli, et al. "Palytoxin toxicity after acute oral administration in mice." Toxicology Letters 191, no. 2-3 (2009): 253–59. http://dx.doi.org/10.1016/j.toxlet.2009.09.009.

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37

Nielsen, Jesper B., Ole Andersen, and Per Svendsen. "EFFECT OF DDC ON ACUTE ORAL Cd TOXICITY." Acta Pharmacologica et Toxicologica 59 (March 13, 2009): 490–93. http://dx.doi.org/10.1111/j.1600-0773.1986.tb02810.x.

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38

Stallard, Nigel. "Optimal adaptive designs for acute oral toxicity assessment." Journal of Statistical Planning and Inference 136, no. 6 (2006): 1781–99. http://dx.doi.org/10.1016/j.jspi.2005.08.004.

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39

Sosa, Silvio, Marco Pelin, Federica Cavion, Fabienne Hervé, Philipp Hess, and Aurelia Tubaro. "Acute Oral Toxicity of Pinnatoxin G in Mice." Toxins 12, no. 2 (2020): 87. http://dx.doi.org/10.3390/toxins12020087.

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Pinnatoxin G (PnTx-G) is a marine cyclic imine toxin produced by the dinoflagellate Vulcanodinium rugosum, frequently detected in edible shellfish from Ingril Lagoon (France). As other pinnatoxins, to date, no human poisonings ascribed to consumption of PnTx-G contaminated seafood have been reported, despite its potent antagonism at nicotinic acetylcholine receptors and its high and fast-acting toxicity after intraperitoneal or oral administration in mice. The hazard characterization of PnTx-G by oral exposure is limited to a single acute toxicity study recording lethality and clinical signs i

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40

Wiemeyer, Stanley N., Elwood F. Hill, James W. Carpenter, and Alexander J. Krynitsky. "ACUTE ORAL TOXICITY OF SODIUM CYANIDE IN BIRDS." Journal of Wildlife Diseases 22, no. 4 (1986): 538–46. http://dx.doi.org/10.7589/0090-3558-22.4.538.

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RIGGS, DAN, and RICHARD E. WEIBLEY. "Acute toxicity from oral ingestion of crack cocaine." Pediatric Emergency Care 6, no. 1 (1990): 24–26. http://dx.doi.org/10.1097/00006565-199003000-00008.

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42

Hwang, Youn-Hwan, Hyunil Ha, and Jin Yeul Ma. "Acute oral toxicity and genotoxicity of Dryopteris crassirhizoma." Journal of Ethnopharmacology 149, no. 1 (2013): 133–39. http://dx.doi.org/10.1016/j.jep.2013.06.011.

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43

Tanaseva, Svetlana A., Evgeniya Yu Tarasova, Lilia E. Matrosova, and Olga K. Ermolaeva. "Acute oral toxicity of Galluasorb in laboratory animals." Vestnik of the Mari State University. Chapter “Agriculture. Economics” 10, no. 1 (2024): 70–78. http://dx.doi.org/10.30914/2411-9687-2024-10-1-70-78.

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44

Phu, Le Hong, Nguyen Cong Thuc, and Dinh Thi Thu Hang. "Examination of the acute and subchronic oral toxicity of “Com Kien Ty” in experimental animals." Tạp chí Nghiên cứu Y học 173, no. 12E13 (2023): 79–86. http://dx.doi.org/10.52852/tcncyh.v173i12e13.2122.

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We evaluate the acute and subchronic toxicities of “Com kien ty” through oral administration in experimental animals. The acute toxicity was determined using the Litchfield Wilcoxon method in mice. Following WHO's recommendation, the subchronic toxicity was assessed in rabbits with oral doses of 0.9 g/kg/day (equal to the recommended human dose) and 2.7 g/kg/day (3 times as high as the recommended human dose) in 4 consecutive weeks. Results showed “Com kien ty” at the highest dose of 60.0 g/kg did not express acute toxicity in mice. Regarding the subchronic toxicity test, after oral administra

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45

Attah, Friday, Moses E. Abalaka, Halimat Abdulsalami, and Philip F. Builders. "Gas chromatography-mass spectrometry analysis, druggability and <i>in-silico</i> dermatopharmacokinetics screening of <i>Mitracarpus scaber</i> extract." Journal of Phytomedicine and Therapeutics 23, no. 2 (2024): 1607–18. https://doi.org/10.4314/jopat.v23i2.17.

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Medicinal plants are an important source of natural compounds used in the development of drugs to treat infectious diseases. The plant Mitracarpus scaber has traditionally been used to treat various ailments, including skin disorders. In this study, GC-MS (gas chromatography-mass spectrometry) analysis was used to identify eighteen bioactive components in the methanolic extract of Mitracarpus scaber whole plants. To assess the druggability and skin pharmacokinetics of these phytocompounds, in silico screening was performed using online programs such as Swiss ADME, pkCSM, ADMETLab 2.0, and Stop

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Rogov, Roman V., Zh Yu Muradyan, and Yulia S. Kruglova. "Study of acute toxicity of protein hydrolysate." Veterinariya, Zootekhniya i Biotekhnologiya 12/2, no. 109 (2022): 79–85. http://dx.doi.org/10.36871/vet.zoo.bio.202212211.

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The article presents the results of preclinical tests of acute oral toxicity of a protein hydrolyzate. The study of the parameters of acute oral toxicity of the protein hydrolyzate was carried out in the conditions of the Department of Disease Diagnostics, Therapy, Obstetrics and Animal Reproduction of the Moscow State Academy of Veterinary Medicine and Biotechnology – MVA by K. I. Skryabin" and on the basis of the International Research Center for Human Health, Animals and the Environment (OOO MNIC «OZOS»). The experiment included white outbred rats weighing 180–210 g. The weight of the anima

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Bulloch, Marilyn N. "Acute Iodine Toxicity from a Suspected Oral Methamphetamine Ingestion." Clinical Medicine Insights: Case Reports 7 (January 2014): CCRep.S20086. http://dx.doi.org/10.4137/ccrep.s20086.

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Background Iodine is a naturally occurring element commercially available alone or in a multitude of products. Iodine crystals and iodine tincture are used in the production of methamphetamine. Although rarely fatal, iodine toxicity from oral ingestion can produce distressing gastrointestinal symptoms and systemic symptoms, such as hypotension and tachycardia, from subsequent hypovolemia. Objective The objective of this case report is to describe a case of iodine toxicity from suspected oral methamphetamine ingestion. Case Report A male in his early 20′s presented with gastrointestinal symptom

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Quan, Hoang Trong, Pham Thuy Phuong, Pham Quoc Binh, Pham Thi Van Anh, and Dinh Thi Thu Hang. "Investigation of “Kien ty chi thong - HV” granules for acute and subchronic oral toxicity in experimental animals." Tạp chí Nghiên cứu Y học 166, no. 5E12 (2023): 1–10. http://dx.doi.org/10.52852/tcncyh.v166i5e12.1448.

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This research is to evaluate the acute and subchronic toxicities of “Kien ty chi thong - HV” granules through oral administration in experimental animals. The acute toxicity was determined by Litchfield Wilcoxon method in Swiss mice. The subchronic toxicity was evaluated by WHO and OECD’s recommendation in Wistar rats with oral doses of 1.8 g/kg/day (equal to recommended human dose) and 5.4 g/kg/day (3 times as high as recommended human dose) in 4 consecutive weeks. As a result, “Kien ty chi thong - HV” granules at the highest dose used in mice (56.25 g/kg) did not express acute toxicity in mi

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Nurbaeti, Siti Nani, Inarah Fajriaty, Fajar Nugraha, et al. "Acute Oral Toxicity of Cincalok Oil in Wistar Rats." Indonesian Journal of Pharmaceutical Science and Technology 8, no. 2 (2021): 51. http://dx.doi.org/10.24198/ijpst.v8i2.26343.

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Cincalok is a West Kalimantan traditional fermented food that has an opportunity to be developed into supplement products as a source of omega 3 and astaxanthin. This study was designed to observe the acute toxicity of Cincalok oil in female rats for its safety profile using AOT 425 program. Cincalok oil for the acute (2000 and 5000 mg/kg) toxicity studies was administered orally according to the OECD guidelines 425. The rat’s body and organs weight were observed then signs of toxicity were assessed. LD50 was being determined at the end of the study. The result showed that a single dose of Cin

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Metodi, Petrichev. "ACUTE PER ORAL TOXICITY OF TILMICOSIN – SUBSTANCE "BIOVET" AD IN WHITE RATS (FISCHER – 344)." TRADITION AND MODERNITY IN VETERINARY MEDICINE 6, no. 1 (2021): 44–48. https://doi.org/10.5281/zenodo.4624275.

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The acute oral toxicity of Tilmicosin – a substance "Biovet" in rats, was studied. 42 male white rats, Fischer 344 line, weighing 160–180 g, were treated with 10% aqueous solution of Tilmicosin phosphate Biovet using a gastric tube. For each dose (500, 1000, 1500, 2000, 2500, 3000 and 3500 mg/body weight), 6 were treated once. Rats, which were monitored for 7 days, taking into account the clinical picture of their intoxication and mortality. Based on the Litchfield-Wilcoxon method used in the test, an average lethal dose of LD50 2200 (2860 ÷ 1692) mg/body weig

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