Relevant bibliographies by topics / Acute phase proteins

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Acute phase proteins'

Author: Grafiati
Published: 4 June 2021
Last updated: 26 July 2024

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Journal articles on the topic "Acute phase proteins"

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Migita, Shunsuke. "Acute phase proteins." SEIBUTSU BUTSURI KAGAKU 30, no. 6 (1986): 387–94. http://dx.doi.org/10.2198/sbk.30.387.

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WHICHER, J. T., and P. A. DIEPPE. "Acute Phase Proteins." Clinics in Immunology and Allergy 5, no. 3 (October 1985): 425–46. http://dx.doi.org/10.1016/s0260-4639(22)00144-x.

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Gruys, E., M. J. M. Toussaint, T. A. Niewold, and S. J. Koopmans. "Acute phase reaction and acute phase proteins." Journal of Zhejiang University SCIENCE 6B, no. 11 (November 2005): 1045–56. http://dx.doi.org/10.1631/jzus.2005.b1045.

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Wakefield, Denis. "Acute Phase Proteins in the Acute Phase Response." Pathology 23, no. 3 (1991): 278. http://dx.doi.org/10.1016/s0031-3025(16)36104-9.

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Weston, KS. "Acute Phase Proteins in the Acute Phase Response." Biochemical Education 18, no. 3 (July 1990): 153. http://dx.doi.org/10.1016/0307-4412(90)90234-f.

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Sipe, Jean D. "Acute-phase proteins in osteoarthritis." Seminars in Arthritis and Rheumatism 25, no. 2 (October 1995): 75–86. http://dx.doi.org/10.1016/s0049-0172(95)80020-4.

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Ceciliani, F., J. J. Ceron, P. D. Eckersall, and H. Sauerwein. "Acute phase proteins in ruminants." Journal of Proteomics 75, no. 14 (July 2012): 4207–31. http://dx.doi.org/10.1016/j.jprot.2012.04.004.

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DREWS, KRZYSZTOF, JANA SKRZYPCZAK, TOMASZ ŻAK, KRZYSZTOF SZYMANOWSKI, and ANDRZEJ MACKIEWICZ. "Acute Phase Proteins in Endometriosis." Annals of the New York Academy of Sciences 762, no. 1 (December 17, 2006): 508–9. http://dx.doi.org/10.1111/j.1749-6632.1995.tb32384.x.

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Correale, Michele, Natale Brunetti, Luisa De Gennaro, and Matteo Biase. "Acute Phase Proteins In Atherosclerosis (Acute Coronary Syndrome)." Cardiovascular & Hematological Agents in Medicinal Chemistry 6, no. 4 (October 1, 2008): 272–77. http://dx.doi.org/10.2174/187152508785909537.

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Jensen, L. E., M. P. Hiney, D. C. Shields, C. M. Uhlar, A. J. Lindsay, and A. S. Whitehead. "Acute phase proteins in salmonids: evolutionary analyses and acute phase response." Journal of Immunology 158, no. 1 (January 1, 1997): 384–92. http://dx.doi.org/10.4049/jimmunol.158.1.384.

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Abstract Inflammation induces dramatic changes in the biosynthetic profile of the liver, leading to increased serum concentrations of positive acute phase (AP) proteins and decreased concentrations of negative AP proteins. Serum amyloid A (SAA) and the pentraxins C-reactive protein (CRP) and serum amyloid P component (SAP) are major AP proteins: their serum levels can rise by 1000-fold, indicating that they play a critical role in defense and/or the restoration of homeostasis. We have cloned SAA and a SAP-like pentraxin from salmonid fish species. The salmonid SAA shares approximately 70% amino acid identity with mammalian AP SAA. When salmonids are challenged with an AP stimulus, i.e., Aeromonas salmonicida, SAA responds dramatically as a major AP reactant. The salmonid pentraxin shows approximately 40% amino acid identity to both mammalian SAP and CRP. Evolutionary analysis suggests the presence of only a single such protein in teleosts and lower animal species. Surprisingly, the salmonid pentraxin behaves as a negative AP reactant, reminiscent of the SAP-like Syrian hamster female protein, in that hepatic mRNA concentrations decline to 50% of prestimulus levels. This study reinforces the hypothesis that SAA induction is an essential and universal feature of the vertebrate AP response and that it represents part of an ancient host defense system. Conversely, the species-dependent heterogeneity of pentraxin expression during the vertebrate AP response supports the possibility that its most important ancestral (and perhaps present) function is not related to its AP behavior.
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Dissertations / Theses on the topic "Acute phase proteins"

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Berling, Rikard. "Acute pancreatitis complications and antiprotease treatment /." Malmö : Departments of Surgical Pathophysiology and Anaesthesiology, University of Lund, University Hospital MAS, 1998. http://catalog.hathitrust.org/api/volumes/oclc/57455677.html.

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Thesis (Doctoral)--Departments of Surgical Pathophysiology and Anaesthesiology, University of Lund, University Hospital MAS.
Added t.p. with thesis statement inserted. Summary in Swedish. Includes bibliographical references.
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O'Reilly, Emily Louise. "Acute phase proteins and biomarkers for health in chickens." Thesis, University of Glasgow, 2016. http://theses.gla.ac.uk/7428/.

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Acute phase proteins (APPs) are proteins synthesised predominantly in the liver, whose plasma concentrations increase (positive APP) or decrease (negative APP) as a result of infection, inflammation, trauma and tissue injury. They also change as a result of the introduction of immunogens such as bacterial lipopolysaccharide (LPS), turpentine and vaccination. While publications on APPs in chickens are numerous, the limited availability of anti-sera and commercial ELISAs has resulted in a lot of information on only a few APPs. Disease is a threat to the poultry industry, as pathogens have the potential to evolve, spread and cause rapid onset of disease that is detrimental to the welfare of birds. Low level, sub-acute disease with non-specific, often undiagnosed causes can greatly affect bird health and growth and impact greatly on productivity and profitability. Developing and validating methods to measure and characterise APPs in chickens will allow these proteins to be used diagnostically for monitoring flock health. Using immune parameters such as APPs that correlate with disease resistance or improvements in production and welfare will allow the use of APPs as selection parameters for breeding to be evaluated. For APPs to be useful parameters on which to evaluate chicken health, information on normal APP concentrations is required. Ceruloplasmin (Cp) and PIT54 concentrations were found to be much lower in healthy birds form commercial production farms than the reported normal values obtained from the literature. These APPs were found to be significantly higher in culled birds from a commercial farm and Cp, PIT54 and ovotransferrin (Ovt) were significantly higher in birds classified as having obvious gait defects. Using quantitative shotgun proteomics to identify the differentially abundant proteins between three pools: highly acute phase (HAP), acute phase (AP) and non-acute phase (NAP), generated data from which a selection of proteins, based on the fold difference between the three pools was made. These proteins were targeted on a individual samples alongside proteins known to be APPs in chickens or other species: serum amyloid A (SAA), C-reactive protein (CRP), Ovt, apolipoprotein A-I (apo-AI), transthyretin (Ttn), haemopexin (Hpx) and PIT54. Together with immunoassay data for SAA, Ovt, alpha-1-acid glycoprotein (AGP) and Cp the results of this research reveal that SAA is the only major APP in chickens. Ovotransferrin and AGP behave as moderate APPs while PIT54 and Cp are minor APPs. Haemopexin was not significantly different between the three acute phase groups. Apolipoprotein AI and Ttn were significantly lower in the HAP and AP groups and as such can be classed as negative APPs. In an effort to identify CRP, multiple anti-sera cross reacting with CRP from other species were used and a phosphorylcholine column known to affinity purify CRP were used. Enriched fractions containing low molecular weight proteins, elutions from the affinity column together with HAP, AP and NAP pooled samples were applied to a Q-Exactive Hybrid Quadrupole–Orbitrap mass spectrometer (Thermo Scientific) for Shotgun analysis and CRP was not identified. It would appear that CRP is not present as a plasma protein constitutively or during an APR in chickens and as such is not an APP in this species. Of the proteins targeted as possible novel biomarkers of the APR in chickens mannan binding lectin associated serine protease-2, α-2-HS-glycoprotein (fetuin) and major facilitator superfamily domain-containing protein 10 were reduced in abundance in the HAP group, behaving as negative biomarkers. Myeloid protein and putative ISG(12)2 were positively associated with the acute phase being significantly higher in the HAP and AP groups. The protein cathepsin D was significantly higher in both HAP and AP compared to the NAP indicating that of all the proteins targeted, this appears to have the most potential as a biomarker of the acute phase, as it was significantly increased in the AP as well as the HAP group. To evaluate APPs and investigate biomarkers of intestinal health, a study using re-used poultry litter was undertaken. The introduction of litter at 12 days of age did not significantly increase any APPs measured using immunoassays and quantitative proteomics at 3, 6 and 10 days post introduction. While no APP was found to be significantly different between the challenged and control groups at anytime point, the APPs AGP, SAA and Hpx did increase over time in all birds. The protein apolipoprotein AIV (apo-AIV) was targeted as a possible APP and because of its reported role in controlling satiety. An ELISA was developed, successfully validated and used to measure apo-AIV in this study. While no significant differences in apo-AIV plasma concentrations between challenged and control groups were identified apo-AIV plasma concentrations did change significantly between certain time points in challenged and control groups. Apoliporotein AIV does not appear to behave as an APP in chickens, as it was not significantly different between acute phase groups. The actin associated proteins villin and gelsolin were investigated as possible biomarkers of intestinal health. Villin was found not to be present in the plasma of chickens and as such not a biomarker target. Gelsolin was found not to be differentially expressed during the acute phase or as a result of intestinal challenge. Finally a proteomic approach was undertaken to investigate gastrocnemius tendon (GT) rupture in broiler chickens with a view of elucidating to and identify proteins associated with risk of rupture. A number of proteins were found to be differentially expressed between tendon pools and further work would enable further detailing of these findings. In conclusion this work has made a number of novel findings and addressed a number of data poor areas. The area of chicken APPs research has stagnated over the last 15 years with publications becoming repetitive and reliant on a small number of immunoassays. This work has sought to characterise the classic APPs in chickens, and use a quantitative proteomic approach to measure and categorise them. This method was also used to take a fresh approach to biomarker identification for both the APR and intestinal health. The development and validation of assays for Ovt and apo-AIV and the shotgun data mean that these proteins can be further characterised in chickens with a view of applying their measurement to diagnostics and selective breeding programs.
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Singh, Harmanjit. "Cytokine-binding and acute-phase plasma proteins in pigs." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ31901.pdf.

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Seebaransingh, Ravi. "Plasma ficolins and acute phase proteins of young pigs." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ43219.pdf.

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Goodarzi, Mohammad T. "Glycosilation of two acute-phase proteins in cancer and inflammation." Thesis, University of Newcastle Upon Tyne, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309405.

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Diack, Abigail. "Study of the genetics of the porcine acute phase proteins." Thesis, University of Glasgow, 2007. http://theses.gla.ac.uk/30971/.

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The principle aims of the work presented in this thesis were to further investigate the porcine acute phase proteins (APP) and determine the factors influencing the baseline concentrations of haptoglobin (Hp), C-reactive protein (CRP), Pig major acute phase protein (Pig-MAP) and transthyretin (TTR). The APP are used as markers of inflammation and sub-clinical disease and are considered potential biomarkers for pig health and welfare. They have also been identified as a possible means of breeding for disease resistance, however little is known about the genetics of the porcine APP. This study investigated associations between the APP genes and baseline concentrations and the heritability of those concentrations. An enzyme linked immunosorbent assay (ELISA) was developed for the measurement of porcine CRP, in-house methods were used for the determination of Hp and TTR and a commercial assay was used in the measurement of Pig-MAP. A population of pure line high health boars (n=~345) from 7 lines was used in the initial study each of which had an archived DNA sample and serum samples available for use. Baseline herd concentrations of the 4 APP were determined and correlations between Hp and CRP, Hp and Pig-Map and CRP and Pig-MAP were identified. Significant differences were found between the 7 breeding lines in CRP, Pig-MAP and TTR concentrations, indicating that selective breeding for performance traits may also have affected innate immune traits such as APP concentrations. Single nucleotide polymoiphisms (SNP) were identified in the 4 APP genes and 17 were genotyped across the boar population with line differences apparent in their allele frequencies for CRP, Pig-MAP and TTR. Statistical analysis showed that there were significant associations between 3 of the SNP located in the Hp gene and Hp baseline concentrations (p < 0.01); all 3 SNP were also in high linkage disequilibrium. The association indicates that Hp is under genetic control and would also be better suited to use as a biomarker due to the lack of line effects in the boars. A heritability study was earned out utilising a mixed sex population of 297 animals (120 male, 177 female) comprising 7 breeding lines located on 2 farms. Initial analysis identified significant differences between male and females in Hp concentration, between pig lines in Hp, CRP and TTR and between the 2 farm units for CRP concentrations. This study showed that the baseline concentrations of the 4 APP could be affected by a variety of factors such as sex, commercial line and individual farm units and this must be taken into account if they are to be used as biomarkers. Heritability was estimated at 0.15, 0.13, 0.12 and 0.07 for Hp, CRP, Pig-MAP and TTR, respectively. All 4 APP show low heritability in serum concentration, this may prove problematic if they are utilised as a breeding trait. Overall, the findings from this study indicate that baseline concentrations of porcine Hp, CRP, Pig-MAP and TTR are influenced by various factors including sex, breeding line, and farm unit and this must be taken into account before they are utilised as biomarkers. They are traits of low heritability but the evidence suggests there may be a genetic component to their regulation thus requiring further investigation.
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Mburu, Anne Susan Wanjiru. "Vitamin A, epithelial integrity and infection : vitamin A micronutrient fortified biscuit supplementation and anthelminthic treatment interventions in rural South African primary school children : maternal vitamin A supplementation interventions in women." Thesis, University of Ulster, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268572.

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Thomas, Funmilola Clara. "Acute phase proteins, proteomics and metabolomics in the diagnosis of bovine mastitis." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/6360/.

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Bovine mastitis continues to pose a major economic challenge to the dairy industry worldwide. Critical to the management and control of this condition, is the need for prompt and accurate diagnosis in field conditions, therefore a search for more sensitive and reliable biomarkers is required. In this thesis, studies focused on assessing milk samples from cows with various forms of mastitis were undertaken with a view to identifying new biomarkers for bovine mastitis. Three acute phase proteins (APP); haptoglobin (Hp), mammary associated serum amyloid A3 (M-SAA3) and C-reactive protein (CRP) were measured in milk samples from composite milk samples of all lactating cows in a commercial dairy herd, mastitis cases, submitted to a diagnostic laboratory and following an experimental mastitis challenge of cows with Streptococcus uberis. A new enzyme linked immunosorbent assay (ELISA) was developed for measuring Hp, while commercial ELISA assay kits were used to assay M-SAA3 and CRP. Other mastitis related parameters evaluated in the samples included the somatic cell counts (SCC) and the presence of pathogens. A reliable and sensitive ELISA was developed and optimized for measuring milk Hp. A cut off value for Hp of 7.9 μg/ml was established for milk with SCC less than 200,000 cells/ml. Pathogen-specific variations were observed in the concentration of each APP in mastitic milk. It was observed that the environmental pathogens showed higher concentrations of APP compared to other pathogens, from the study of mastitis milk samples submitted to the diagnostic laboratory. Also, it was possible to distinguish between samples from subclinical and clinical mastitis and between samples from subclinical and healthy udders using each of the APP (P<0.05). Haptoglobin, M-SAA3 and CRP showed corresponding variation with stage of infection during the course of experimental mastitis, and specifically CRP was observed to rise earlier than other two APP. Furthermore, characterization of the profile of these APP in the immediate post-calving milk samples was carried out to determine how valuable they would be in recognizing new mastitis infections arising at the post-partum period. It was observed that there is a general moderately-high level of APP in milk immediately following parturition which drops a few days later in healthy milk. The immunohistochemical localization of Hp in the bovine mammary gland was also assessed. It could be concluded from that study that neutrophils and the mammary epithelial cells secrete Hp into milk during mastitis. Gel and non-gel based proteomics approaches were employed to study the protein profiles and variation in mastitic milk from normal samples. Several proteins were identified that confirmed previous findings and project new mastitis markers, for example, serotransferrin, serpins, alpha-macroglobulin and neutrophil gelatinase associated lipocalins. A capillary electrophoresis mass spectrometry system (CE-MS) was also employed to elucidate the changing peptidome in milk during the course of an experimental mastitis, which lead to the generation of a panel of 77 polypeptides, which were able to significantly differentiate critical stages of mastitis. Three of these polypeptides were found in mastitic milk samples from previous peptidomic analyses thereby indicating strong biomarker value. Finally, a liquid chromatography mass spectrometry based metabolomics approach was used to study the changing profile of small metabolites in milk during the course of an experimental infection. Several pathway-based changes that highlighted metabolites of potential significance in mastitis diagnosis were recognized including lactose synthesis, nitrogen containing compounds such as betaine, L-carnitine and lipid metabolites pathways namely sn-glycerophosphocholine and choline among others. Overall, this study has shown the value of APP, milk proteomics and metabolomics in bovine mastitis diagnosis; the changing proteins and metabolites or their patterns need to be further experimentally and clinically validated as specific and sensitive markers of mastitis. Ultimately, the applicability of APP, proteins, peptides and metabolites and/or their changing patterns as mastitis biomarkers would require their adaptation to rapid (on farm) and robust measurement formats.
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Sheldon, Joanna. "Interrelationships between markers and mediators of the inflammatory and immune responses." Thesis, Brunel University, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285054.

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Sarlo, Katherine. "Some biological properties of the mouse acute phase reactant serum amyloid p-component /." The Ohio State University, 1985. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487262513407963.

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Books on the topic "Acute phase proteins"

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Pepys, M. B., ed. Acute Phase Proteins in the Acute Phase Response. London: Springer London, 1989. http://dx.doi.org/10.1007/978-1-4471-1739-1.

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B, Pepys M., ed. Acute phase proteins in the acute phase response. London: Springer-Verlag, 1989.

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Andrzej, Mackiewicz, Kushner Irving 1929-, and Baumann Heinz 1947-, eds. Acute phase proteins: Molecular biology, biochemistry, and clinical applications. Boca Raton: CRC Press, 1993.

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Some aspects of induced protein synthesis in liver cells: Regulatory effects of interleukin-6, insulin, glicated proteins and polyglucans. Kraków: Wydawn. Uniwersytetu Jasgiellońskiego, 1997.

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T, Whicher J., and Evans S. W, eds. Biochemistry of inflammation. Dordrecht: Kluwer Academic Publishers, 1992.

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B, Sehgal Pravinkumar, Grieninger Gerd, Tosato Giovanna, New York Academy of Sciences., and National Foundation for Cancer Research., eds. Regulation of the acute phase and immune responses: Interleukin-6. New York, N.Y: New York Academy of Sciences, 1989.

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H, Gordon A., and Koj A, eds. The Acute-phase response to injury and infection: The roles of interleukin I and other mediators. Amsterdam: Elsevier, 1985.

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E, Sim, ed. Humoral factors. Oxford: IRL Press at Oxford University Press, 1993.

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Janciauskiene, Sabina, ed. Acute Phase Proteins. InTech, 2013. http://dx.doi.org/10.5772/46063.

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Acute Phase Proteins. CRC Press, 1993.

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Book chapters on the topic "Acute phase proteins"

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Champion, Howard R., Nova L. Panebianco, Jan J. De Waele, Lewis J. Kaplan, Manu L. N. G. Malbrain, Annie L. Slaughter, Walter L. Biffl, et al. "Acute Phase Proteins." In Encyclopedia of Intensive Care Medicine, 78. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-00418-6_3008.

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Abrams, David B., J. Rick Turner, Linda C. Baumann, Alyssa Karel, Susan E. Collins, Katie Witkiewitz, Terry Fulmer, et al. "Acute Phase Proteins." In Encyclopedia of Behavioral Medicine, 30. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-1005-9_100026.

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Parry, Claire L. "Acute Phase Proteins." In The Clinical Chemistry of Laboratory Animals, 677–744. Third edition. | Boca Raton : Taylor & Francis, 2017.: CRC Press, 2017. http://dx.doi.org/10.1201/9781315155807-19.

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Böning, Dieter, Michael I. Lindinger, Damian M. Bailey, Istvan Berczi, Kameljit Kalsi, José González-Alonso, David J. Dyck, et al. "Acute Phase Proteins (APPs)." In Encyclopedia of Exercise Medicine in Health and Disease, 13. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-29807-6_2017.

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Colten, H. R., and J. D. Gitlin. "Molecular Regulation of the Acute Phase Complement Proteins." In Acute Phase Proteins in the Acute Phase Response, 85–96. London: Springer London, 1989. http://dx.doi.org/10.1007/978-1-4471-1739-1_7.

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Feldmann, G., D. Bernuau, J. Y. Scoazec, and M. Maurice. "Biosynthesis of Acute Phase Proteins by the Liver Cells." In Acute Phase Proteins in the Acute Phase Response, 97–105. London: Springer London, 1989. http://dx.doi.org/10.1007/978-1-4471-1739-1_8.

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Gauldie, J. "Interleukin-1 in the Acute Phase Response." In Acute Phase Proteins in the Acute Phase Response, 1–20. London: Springer London, 1989. http://dx.doi.org/10.1007/978-1-4471-1739-1_1.

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White, H. E., B. P. O’Hara, G. Oliva, T. L. Blundell, M. B. Pepys, and S. P. Wood. "The Three Dimensional Structure of SAP." In Acute Phase Proteins in the Acute Phase Response, 123–36. London: Springer London, 1989. http://dx.doi.org/10.1007/978-1-4471-1739-1_10.

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de Beer, F. C., A. F. Strachan, and E. G. Shephard. "Structure, Metabolism and Function of Acute Phase High Density Lipoprotein." In Acute Phase Proteins in the Acute Phase Response, 137–50. London: Springer London, 1989. http://dx.doi.org/10.1007/978-1-4471-1739-1_11.

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Laurent, P. E. "Clinical Measurement of Acute Phase Proteins to Detect and Monitor Infectious Diseases." In Acute Phase Proteins in the Acute Phase Response, 151–60. London: Springer London, 1989. http://dx.doi.org/10.1007/978-1-4471-1739-1_12.

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Conference papers on the topic "Acute phase proteins"

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Sorokina, E. G., S. A. Afanasieva, T. V. Radygina, S. V. Petrichuk, A. S. Potapov, E. L. Semikina, and V. P. Reutov. "THE CONTENT OF SERUM PROTEINS, MODIFIED ALBUMIN AND 3-NITROTHYROSINE IN CHILDREN WITH INFLAMMATORY BOWEL DISEASES." In NOVEL TECHNOLOGIES IN MEDICINE, BIOLOGY, PHARMACOLOGY AND ECOLOGY. LLC Institute Information Technologies, 2023. http://dx.doi.org/10.47501/978-5-6044060-3-8.93-100.

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The article presents data on the content of albumin, ischemia modified albumin, protein frac-tions and 3-nitrothyrosine in the blood serum of children with different severity of inflamma-tory bowel diseases (IBD in remission and exacerbation). It has been shown that the more severe the condition, the more pronounced the decrease in albumin. On the contrary, the content of acute phase proteins, modified albumin and 3-nitrothyrosine (NT) increases with increasing severity of IBD.
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Gram, J., C. Kluft, and J. Jespersen. "CHANGES IN t-PA ACTIVITY AND INHIBITION AS PART OF THE ACUTE PHASE REACTION IN ACUTE MYOCARDIAL INFARCTION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643014.

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Acute myocardial infarction (AMI) is accompanied by sequential fluctuations in several plasma proteins indicative of an acute phase reaction. Global screening tests (ECLT and WBCLT) have revealed temporary depression of systemic fibrinolysis. However, such tests do not allow definite conclusions regarding the specific variables involved.In a prospective study of 34 patients with AMI we determined selected variables involved in fibrinolysis, and in addition we investigated whether any fluctuation was related to the development of leg vein thrombosis (isotope-technique) or due to AMI. Blood samples were collected on days 1,2,4,6,8 after admission and eight weeks (recovery) after discharge. Euglobulin fibrinolytic activity was determined on fibrin plates. The measured activity was lower in the initial acute period (≤ 48 h after AMI) than in the recovery period (p<0.05). The intrinsic fibrinolytic proactivators (representing more than 95% of the total activator potential of plasma) did not change during the period of study. Levels in the euglobulins of C1-inactivator (the main inhibitor of the intrinsic system) were constant during the first 48 hours. This suggests that the observed reduction represents t-PA activity and this was verified by specific assay of t-PA. The t-PA inhibition capacity in plasma was elevated in the initial acute period compared to the recovery period (week 8; p<0.05). C-reactive protein and fibrinogen followed another pattern with the highest plasma level at day 4 and day 6, respectively. Plasma levels of C1-inactivator increased slowly with a peak at day 8. There was no difference of the determined variables between the DVT negative and positive group, suggesting that the observed changes were due to myocardial injury. Our findings show that components of the fibrinolytic system take part in the acute phase reaction following AMI, and that this involves a brief, initial period of reduced fibrinolytic potential (<48h). The initial, high levels of t-PA inhibition deserve consideration in regard to the institution of thrombolytic therapy with t-PA. (Undertaken within the frame of ECAT).
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Ehlting, Christian, Maximilian J. Hahnel, Anastasiya Skryabin, Stephanie D. Wolf, Matthias Gaestel, Tom Lüdde, and Johannes Bode. "MK2 limits the production of distinct acute-phase proteins by controlling the composition of gene expression modulators." In 39. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber. Georg Thieme Verlag, 2023. http://dx.doi.org/10.1055/s-0042-1759919.

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Dee, Anne, Roberta McKean-Cowdin, Marian L. Neuhouser, Cornelia M. Ulrich, Catherine M. Alfano, Richard M. Baumgartner, Anne McTiernan, Rachel Ballard-Barbash, and Leslie Bernstein. "Abstract 2777: DEXA measures of body fat percentage and relation to acute phase proteins among breast cancer survivors." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-2777.

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Esmedlyaeva, Diljara, Nina Alexeeva, Larisa Kiryukhina, Maria Pavlova, Viacheslav Zhuravlev, and Marina Dyakova. "Matrix metalloproteinases (MMPs) and acute phase proteins (APP) in predicting the efficacy of intensive phase treatment (IPP) in patients with pulmonary tuberculosis (PT)." In ERS International Congress 2016 abstracts. European Respiratory Society, 2016. http://dx.doi.org/10.1183/13993003.congress-2016.pa2724.

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Lechowicz, U., A. Zdral, A. Roży, S. Janciauskiene, and J. Chorostowska-Wynimko. "Blood neutrophil adhesion properties and plasma levels of acute-phase proteins in subjects with PiMM and PiZZ alpha1-antitrypsin." In ERS International Congress 2022 abstracts. European Respiratory Society, 2022. http://dx.doi.org/10.1183/13993003.congress-2022.2479.

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Janciauskiene, Sabina, Pierre-Joseph Royer, Jan Fuge, Sabine Wrenger, Joanna Chorostowska, Huiyuan Zhu, Tobias Welte, et al. "Plasma levels of acute phase proteins in patients from the multicenter longitudinal French Cohort in Lung Transplantation (COLT): a pilot study." In ERS International Congress 2020 abstracts. European Respiratory Society, 2020. http://dx.doi.org/10.1183/13993003.congress-2020.4729.

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Petrović, Miloš, Radojica Đoković, Vladimir Kurćubić, Snežana Bogosavljević-Bošković, Simeon Rakonjac, and Milun Petrović. "Intracellular and extracellular Hsp70 in cows: Similarities and differences in physiological and pathophysiology conditions." In Zbornik radova 26. medunarodni kongres Mediteranske federacije za zdravlje i produkciju preživara - FeMeSPRum. Poljoprivredni fakultet Novi Sad, 2024. http://dx.doi.org/10.5937/femesprumns24025p.

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Heat shock proteins (Hsp), also called chaperones, are proteins that are indispensable for the proper formation of the polypeptide chain; and have a role in its translocation within the cell. Hsp70 in cells helps to re-establish the native conformation of proteins that have denatured under the influence of various stressogens, by preventing their aggregation, which results in protecting the cell from apoptosis and having an anti-inflammatory effect. These proteins are classified on the basis of molecular mass, and the most significant is heat shock protein 70 (Hsp70) with a molecular mass of about 70 kDa, which is designated as "a master player in protein homeostasis". The concentration of Hsp increases significantly when exposed to a stressor originating from the cell itself or from the external environment. Many chaperones are induced under the influence of high ambient temperatures, when the universal heat shock response (HSR) develops, which is why the name heat shock proteins was defined. Intracellular Hsp70 (iHsp70) shows its protective and anti-inflammatory effects. Induced iHsp70 protects the cell from apoptosis by reducing or blocking the activation of caspases, binding to apoptosis-inducing factor (AIF) and inhibiting AIF-induced chromatin condensation or preventing mitochondrial damage and nuclear fragmentation. It blocks cell morphological changes caused by tumor necrosis factor-induced apoptosis, and has been found to aid in cell repair of damage caused by inflammation. The anti-inflammatory effect of iHsp70 is reflected in the fact that it inhibits the response to lipopolysaccharides and blocks the production of inflammatory mediators such as tumor necrosis factor Alpha (TNF-a), and other mechanisms have been described. he expression of the gene for the production of Hsp70 has been well studied in ruminants or their cell cultures exposed to high ambient temperatures, and the multiple increase of iHsp70 in the cells results in a better adaptation to heat stress. The study of eHsp70 has become relevant due to the availability of diagnostic kits for determining its concentration, and the latest results show that it is a very useful predictor of mortality in patients with septic shock. Hsp70 moves to the extracellular space in several ways: after leaving necrotic cells, under the action of various stress factors and inflammation in undamaged cells, it can be produced in the liver as an acute phase protein, and transport by exosomes and direct contact with the lipid membrane of cells have also been described. The pro-inflammatory effect of eHsp70 is realized by inducing immune cells, which further induces the secretion of inflammatory cytokines (TNF-a, IL-1b, IL-6), inducible nitric oxide synthase (iNOS) expression and nuclear translocation of nuclear factor-cB (NF-cB). According to the chaperone balance theory, the higher the value of eHsp70 compared to iHsp70, the more pronounced its proinflammatory effects. This hypothesis was also confirmed in dairy cows in the periparturient period.
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Swahn, E., H. von Schenck, and L. Wallentin. "PLATELET REACTIVITY AND FIBRINOGEN LEVELS IN UNSTABLE CORONARY ARTERY DISEASE(UCAD)." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643008.

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Unstable angina and non-Q-wave myocardial infarction represents the unstable phase Of coronary artery disease (CAD). In UCAD a thrombosis in a coronary artery could be the triggering factor of the unstable phase. Increased platelet reactivity and hypercoagulability could be the predisposing factor for developing this condition. Therefore, in patients with UCAD the platelet reactivity was measured as the aggregation response to ADP and collagen, the platelet sensitivity to PgI2 and the release of platelet derived proteins. As an indicator of hypercoagulability the fibrinogen level in plasma was analysed. The control group consisted of patients with chest pain but without CAD. Blood samples for platelet tests and fibrinogen analysis were obtained in the acute phase and after one year.Results.: The only difference in platelet reactivity between cases and controls was noted in their sensitivity to PgI2. The difference remained in the females but not in the male UCAD group after one year.In the acute phase a diagnosis of UCAD, elevated weight index and smoking contributed independently to increased fibrinogen levels.Conclusion: The increased fibrinogen level and decreased platelet sensitivity to PgI2 might reflect a hypercoagulable state in patients with UCAD.
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Wrenger, S., U. Lechowicz, B. Liu, B. Martinez-Delgado, T. Welte, J. Chorostowska, and S. Janciauskiene. "Plasma acute phase proteins with specific emphases on alpha1-antitrypsin polymers and transcriptome of blood neutrophils in PiMM and PiZZ COPD patients." In 64. Kongress der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e. V. Georg Thieme Verlag, 2024. http://dx.doi.org/10.1055/s-0044-1778872.

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Reports on the topic "Acute phase proteins"

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Yogev, David, Ricardo Rosenbusch, Sharon Levisohn, and Eitan Rapoport. Molecular Pathogenesis of Mycoplasma bovis and Mycoplasma agalactiae and its Application in Diagnosis and Control. United States Department of Agriculture, April 2000. http://dx.doi.org/10.32747/2000.7573073.bard.

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Mycoplasma bovis and M. agalactiae are two phylogenetically related mycoplasmas which cause economically significant diseases in their respective bovine or small ruminant hosts. These organisms cause persistent asymptomatic infections that can result in severe outbreaks upon introduction of carrier animals into susceptible herds. Little is known about the mechanisms underlying mycoplasma-host interaction, variation in virulence, or of the factors enabling avoidance of the host immune system. In recent years it has become apparent that the ability of pathogenic microorganisms to rapidly alter surface antigenic structures and to fine tune their antigenicity, a phenomena called antigenic variation, is one of the most effective strategies used to escape immune destruction and to establish chronic infections. Our discovery of a novel genetic system, mediating antigenic variation in M. bovis (vsp) as well as in M. agalactiae (avg) served as a starting point for our proposal which included the following objectives: (i) Molecular and functional characterization of the variable surface lipoproteins (Vsp) system of M. bovis and comparison with the Vsp-counterpart in M. agalactiae (ii) Determination of the role of Vsp proteins in the survival of M. bovis when confronted by host defense factors, (iii) Assessment of Vsp-based genetic and antigenic typing of M. bovis and M. agalactiae for epidemiology of infection and (iv) Improvement of diagnostic tests for M. bovis and M. agalactiae based on the vsp-and vsp-analogous systems. We have carried out an extensive molecular characterization of the vsp system and unravelled the precise molecular mechanism responsible for the generation of surface antigenic variation in M. bovis. Our data clearly demonstrated that the two pathogenic mycoplasma species possess large gene families encoding variable lipoprotein antigens that apparently play an important role in immune evasion and in pathogen-host interaction during infection. Phase variable production of these antigens was found to be mediated by a novel molecular mechanism utilizing double site-specific DNA inversions via an intermediate vsp configuration. Studies in model systems indicate that phase variation of VspA is relevant in interaction between M. bovis and macrophages or monocytes, a crucial stage in pathogenesis. Using an ELISA test with captured VspA as an antigen, phase variation was shown to occur in vivo and under field conditions. Genomic rearrangements in the avg gene family of M. agalactiae were shown to occur in vivo and may well have a role in evasion of host defences and establishment of chronic infection. An epidemiological study indicated that patterns of vsp-related antigenic variation diverge rapidly in an M. bovis infected herd. Marked divergence was also found with avg-based genomic typing of M. agalactiae in chronically infected sheep. However, avg-genomic fingerprints were found to be relatively homogeneous in different animals during acute stages of an outbreak of Contagious Agalactiae, and differ between unrelated outbreaks. These data support the concept of vsp-based genomic typing but indicate the necessity for further refinement of the methodology. The molecular knowledge on these surface antigens and their encoding genes provides the basis for generating specific recombinant tools and serological methods for serodiagnosis and epidemiological purposes. Utilization of these methods in the field may allow differentiating acutely infected herds from chronic herds and disease-free herds. In addition the highly immunogenic nature of these lipoproteins may facilitate the design of protective vaccine against mycoplasma infections.
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Wagner, D. Ry, Eliezer Lifschitz, and Steve A. Kay. Molecular Genetic Analysis of Flowering in Arabidopsis and Tomato. United States Department of Agriculture, May 2002. http://dx.doi.org/10.32747/2002.7585198.bard.

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The primary objectives for the US lab included: the characterization of ELF3 transcription and translation; the creation and characterization of various transgenic lines that misexpress ELF3; defining genetic pathways related to ELF3 function regulating floral initiation in Arabidopsis; and the identification of genes that either interact with or are regulated by ELF3. Light quality, photoperiod, and temperature often act as important and, for some species, essential environmental cues for the initiation of flowering. However, there is relatively little information on the molecular mechanisms that directly regulate the developmental pathway from the reception of the inductive light signals to the onset of flowering and the initiation of floral meristems. The ELF3 gene was identified as possibly having a role in light-mediated floral regulation since elj3 mutants not only flower early, but exhibit light-dependent circadian defects. We began investigating ELF3's role in light signalling and flowering by cloning the ELF3 gene. ELF3 is a novel gene only present in plant species; however, there is an ELF3 homolog within Arabidopsis. The Arabidopsis elj3 mutation causes arrhythmic circadian output in continuous light; however, we show conclusively normal circadian function with no alteration of period length in elj3 mutants in dark conditions and that the light-dependent arrhythmia observed in elj3 mutants is pleiotropic on multiple outputs regardless of phase. Plants overexpressing ELF3 have an increased period length in constant light and flower late in long-days; furthermore, etiolated ELF3-overexpressing seedlings exhibit a decreased acute CAB2 response after a red light pulse, whereas the null mutant is hypersensitive to acute induction. This finding suggests that ELF3 negatively regulates light input to both the clock and its outputs. To determine whether ELF3's action is phase dependent, we examined clock resetting by light pulses and constructed phase response curves. Absence of ELF3 activity causes a significant alteration of the phase response curve during the subjective night, and overexpression of ELF3 results in decreased sensitivity to the resetting stimulus, suggesting that ELF3 antagonizes light input to the clock during the night. Indeed, the ELF3 protein interacts with the photoreceptor PHYB in the yeast two-hybrid assay and in vitro. The phase ofELF3 function correlates with its peak expression levels of transcript and protein in the subjective night. ELF3 action, therefore, represents a mechanism by which the oscillator modulates light resetting. Furthermore, flowering time is dependent upon proper expression ofELF3. Scientifically, we've made a big leap in the understanding of the circadian system and how it is coupled so tightly with light reception in terms of period length and clock resetting. Agriculturally, understanding more about the way in which the clock perceives and relays temporal information to pathways such as those involved in the floral transition can lead to increased crop yields by enabling plants to be grown in suboptimal conditions.
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Firon, Nurit, Prem Chourey, Etan Pressman, Allen Hartwell, and Kenneth J. Boote. Molecular Identification and Characterization of Heat-Stress-Responsive Microgametogenesis Genes in Tomato and Sorghum - A Feasibility Study. United States Department of Agriculture, October 2007. http://dx.doi.org/10.32747/2007.7591741.bard.

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Exposure to higher than optimal temperatures - heat-stress (HS) - is becoming increasingly common to all crop plants worldwide. Heat stress coinciding with microgametogenesis, especially during the post-meiotic phase that is marked by starch biosynthesis, is often associated with starch-deficient pollen and male sterility and ultimately, greatly reduced crop yields. The molecular basis for the high sensitivity of developing pollen grains, on one hand, and factors involved in pollen heat-tolerance, on the other, is poorly understood. The long-term goal of this project is to provide a better understanding of the genes that control pollen quality under heat-stress conditions. The specific objectives of this project were: (1) Determination of the threshold heat stress temperature(s) that affects tomato and sorghum pollen quality whether: a) Chronic mild heat stress conditions (CMHS), or b) Acute heat stress (AHS). (2) Isolation of heat-responsive, microgametogenesis-specific sequences. During our one-year feasibility project, we have accomplished the proposed objectives as follows: Objectrive 1: We have determined the threshold HS conditions in tomato and sorghum. This was essential for achieving the 2nd objective, since our accumulated experience (both Israeli and US labs) indicate that when temperature is raised too high above "threshold HS levels" it may cause massive death of the developing pollen grains. Above-threshold conditions have additional major disadvantages including the "noise" caused by induced expression of genes involved in cell death and masking of the differences between heatsensitive and heat-tolerant pollen grains. Two different types of HS conditions were determined: a) Season-long CMHS conditions: 32/26°C day/night temperatures confirmed in tomato and 36/26°C day maximum/night minimum temperatures in sorghum. b) Short-term AHS: In tomato, 2 hour exposure to 42-45°C (at 7 to 3 days before anthesis) followed by transfer to 28/22±2oC day/night temperatures until flower opening and pollen maturation, caused 50% reduced germinating pollen in the heat-sensitive 3017 cv.. In sorghum, 36/26°C day/night temperatures 10 to 5 days prior to panicle emergence, occurring at 35 days after sowing (DAS) in cv. DeKalb28E, produced starch-deficient and sterile pollen. Objective 2: We have established protocols for the high throughput transcriptomic approach, cDNA-AFLP, for identifying and isolating genes exhibiting differential expression in developing microspores exposed to either ambient or HS conditions and created a databank of HS-responsivemicrogametogenesis-expressed genes. A subset of differentially displayed Transcript-Derived Fragments (TDFs) that were cloned and sequenced (35 & 23 TDFs in tomato and sorghum, respectively) show close sequence similarities with metabolic genes, genes involved in regulation of carbohydrate metabolism, genes implicated in thermotolerance (heat shock proteins), genes involved in long chain fatty acids elongation, genes involved in proteolysis, in oxidation-reduction, vesicle-mediated transport, cell division and transcription factors. T-DNA-tagged Arabidopsis mutants for part of these genes were obtained to be used for their functional analysis. These studies are planned for a continuation project. Following functional analyses of these genes under HS – a valuable resource of genes, engaged in the HS-response of developing pollen grains, that could be modulated for the improvement of pollen quality under HS in both dicots and monocots and/or used to look for natural variability of such genes for selecting heat-tolerant germplasm - is expected.
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Zhao, Zepeng, Fengyuan Zhang, and Yijin Li. The Relationship Between Il-1 RN intron 2 (VNTR) rs2234663 Gene Polymorphism and The Progression of Periodontitis: A systematic Review and Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, March 2023. http://dx.doi.org/10.37766/inplasy2023.3.0100.

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Review question / Objective: The aim of this systematic review and meta-analysis of case-control studies is to find out the association of IL-1 RN intron 2 (VNTR) rs2234663 Gene Polymorphism and the occurrence and progression of periodontitis(including chronic periodontitis, aggressive periodontitis and early-onset periodontitis). Condition being studied: Periodontitis is one of the most common ailments affecting the teeth, leading to the destruction of the supporting and surrounding tooth structure. Periodontitis is originally a disease originating from the gingival tissue which if left untreated results in penetration of inflammation to the deeper tissues, altering the bone homeostasis causing tooth loss. Periodontal disease has a multifactorial origin. The main culprit identified in periodontitis is the bacterial biofilm growing on the tooth surfaces. The deleterious effects of periodontopathogens are not limited to the periodontium, but they also exude their ill effects on the systemic health of the patients. While the host response determines the progression of the disease, genetics, environmental factors, systemic health of the patient, lifestyle habits and various social determinants also play a role. Interleukin-1 receptor antagonist encoded by this gene IL-1RN is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses, particularly in the acute phase of infection and inflammation. We aim to study their association by conducting a meta-analysis.
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