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Journal articles on the topic 'Acute radiation toxicity'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Das, Jahnabi, Gunaseelan K, Saravanan K, and Chandramouli R. "Evaluation of Radiation Dosimetric Parameters and its Association with Acute Skin Toxicity in Whole Breast Radiation." International Journal of Science and Research (IJSR) 10, no. 3 (2021): 1282–90. https://doi.org/10.21275/sr21318230330.

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2

Stepanović, Aleksandar, Tatjana Arsenijević, Aleksandar Tomašević, et al. "Acute radiation toxicity in glioblastoma patients undergoing hypofractionated radiotherapy." Medicinska istrazivanja 57, no. 4 (2024): 7–13. https://doi.org/10.5937/medi57-52237.

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Introduction. Hypofractionated radiotherapy is the preferred regimen for older patients with glioblastoma and those with poor prognostic factors. Acute radiation toxicity remains a concern in these cases. Aim. We conducted a retrospective analysis aiming to show the acute toxicity profile in patients with glioblastoma treated with hypofractionated radiotherapy, with or without temozolomide. Material and Methods. This study included 25 patients with diagnosed glioblastoma who underwent a hypofractionated regimen of radiotherapy, with a dose of 40 Gy in 15 fractions or 34 Gy in 10 fractions. Acu

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Albrecht, Fenja, Heidi Wolters, Yvonne Ziert, et al. "Evaluation of treatment-associated eye toxicity after irradiation in childhood and adolescence—results from the Registry of the Evaluation of Side Effects after Radiotherapy in Childhood and Adolescence (RiSK)." Strahlentherapie und Onkologie 197, no. 8 (2021): 700–710. http://dx.doi.org/10.1007/s00066-021-01793-2.

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Abstract Purpose The aim of the study is to evaluate treatment-related acute and late eye toxicity associated with radiation therapy in childhood and adolescence as correlated with RT (radiotherapy) doses. Methods From 2001 to 2016, a total of 1725 children and adolescents undergoing radiation therapy were prospectively documented in the Registry of the Evaluation of Side Effects after Radiotherapy in Childhood and Adolescence (RiSK). The RTOG/EORTC criteria were used to classify ocular acute and late effects. Uni- and multivariate analyses were carried out to evaluate the impact of patient ag

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Soni, S., P. Agrawal, N. Kumar, et al. "Salivary biochemical markers as potential acute toxicity parameters for acute radiation injury." Human & Experimental Toxicology 35, no. 3 (2015): 221–28. http://dx.doi.org/10.1177/0960327115579433.

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Researchers have been evaluating several biodosimetric/screening approaches to assess acute radiation injury, related to mass causality. Keeping in mind this background, we hypothesized that effect of whole-body irradiation in single fraction in graded doses can affect the secretion of various salivary components that could be used as acute radiation injury/toxicity marker, which can be used in screening of large population at the time of nuclear accidents/disaster. Thirty Sprague Dawley rats treated with whole-body cobalt-60 gamma irradiation of dose 1–5 Gy (dose rate: 0.95 Gy/min) were inclu

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Hercbergs, Aleck. "Early onset acute radiation toxicity and amiodarone." International Journal of Radiation Oncology*Biology*Physics 16, no. 2 (1989): 525. http://dx.doi.org/10.1016/0360-3016(89)90355-6.

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Oh, Suk Y., Heidi Storm, Stata Norton, and Bruce Kimler. "Radiation death and acute radiation toxicity: Modification by dietary squalene." Free Radical Biology and Medicine 9 (January 1990): 174. http://dx.doi.org/10.1016/0891-5849(90)90790-p.

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Stanić, Jelena, Vesna Stanković, and Marina Nikitović. "Radiation toxicity in prostate cancer patients." Medicinski podmladak 72, no. 2 (2021): 26–33. http://dx.doi.org/10.5937/mp72-32377.

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Prostate cancer (PC) is the most frequent male tumor, accounting for about one-third of all cancers in men. Since survival is often favorable regardless of therapy, treatment decisions may depend on therapy-specific health outcomes. The majority of men initially diagnosed with localized PC ultimately die with, rather than of, their disease. As a result, men who are diagnosed will live many years with the treatment's sequelae. The major therapeutic strategies include radical prostatectomy or external beam radiotherapy. Radiotherapy is one of the curative treatment options. The tumor dose-respon

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Peach, Matthew Sean, Timothy N. Showalter, and Nitin Ohri. "Systematic Review of the Relationship between Acute and Late Gastrointestinal Toxicity after Radiotherapy for Prostate Cancer." Prostate Cancer 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/624736.

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A small but meaningful percentage of men who are treated with external beam radiation therapy for prostate cancer will develop late gastrointestinal toxicity. While numerous strategies to prevent gastrointestinal injury have been studied, clinical trials concentrating on late toxicity have been difficult to carry out. Identification of subjects at high risk for late gastrointestinal injury could allow toxicity prevention trials to be performed using reasonable sample sizes. Acute radiation therapy toxicity has been shown to predict late toxicity in several organ systems. Late toxicities may oc

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Stojanovic-Rundic, Suzana, Vesna Plesinac-Karapandzic, Aleksandar Rankovic, et al. "Radiation induced toxicity in rectal cancer patients." Acta chirurgica Iugoslavica 63, no. 1 (2016): 33–41. http://dx.doi.org/10.2298/aci1601033s.

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Preoperative radiotherapy ? chemotherapy became the standard treatment for locally advanced rectal cancer. Despite better local control with this approach, there was not seen a significant improvement in overall survival and disease free survival, yet. The main disadvantage is toxicity that can be developed, especially concomitantly with chemotherapy. Toxicity can be acute and late. Acute complications are transitory, but late might lead to permanent damage and consequently are more significant for patients. Today, there are technical opportunities in reduction of acute and late radiation toxi

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Ito, Makoto, Yasuo Yoshioka, Yuuki Takase, et al. "Stereotactic body radiation therapy for Japanese patients with localized prostate cancer: 2-year results and predictive factors for acute genitourinary toxicities." Japanese Journal of Clinical Oncology 51, no. 8 (2021): 1253–60. http://dx.doi.org/10.1093/jjco/hyab094.

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Abstract Objective We aimed to report the 2-year results of stereotactic body radiation therapy for prostate cancer and identify the clinical and dosimetric factors that predict acute genitourinary toxicities. Methods We retrospectively reviewed the medical records of patients with non-metastatic prostate cancer treated at Toyota Memorial Hospital between 2017 and 2020. The patients were treated with stereotactic body radiation therapy with a total dose of 36.25 Gy in five fractions on consecutive weekdays. While low-risk patients received radiotherapy alone, intermediate- to high-risk patient

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Bahary, J., K. Bae, D. Taussky, M. Roach, H. M. Sandler, and W. U. Shipley. "Does timing of androgen deprivation influence radiation-induced toxicity? A secondary analysis of Radiation Therapy Oncology Group protocol 9413." Journal of Clinical Oncology 24, no. 18_suppl (2006): 4655. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.4655.

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4655 Background: We conducted a secondary analysis of RTOG 9413 to compare if the timing of antiandrogen-therapy, concomitant versus adjuvant, influences the incidence of rectal toxicity in whole pelvic radiotherapy. Methods: For the purpose of this secondary analysis, we analyzed the 2 of the 4 arms of the study, in which all patients received radiotherapy to the whole pelvis followed by a boost to the prostate and excluded the two arms that received prostate only radiotherapy. The 2 arms differed only in the timing of the total of 4 months of total androgen deprivation (TAD): arm I (320 pati

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Pulvirenti, Trish, Angela Hong, Arthur Clements, et al. "Acute Radiation Skin Toxicity Associated With BRAF Inhibitors." Journal of Clinical Oncology 34, no. 3 (2016): e17-e20. http://dx.doi.org/10.1200/jco.2013.49.0565.

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13

Lee, B. K., D. Apkon, J. Wolfe, and K. J. Marcus. "Palliative Radiation Therapy for Pediatric Patients: Acute Toxicity." International Journal of Radiation Oncology*Biology*Physics 101, no. 4 (2018): 1006. http://dx.doi.org/10.1016/j.ijrobp.2018.01.078.

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Choubey, Subhadra, Harihar Nath Tiwari, Rajesh Kumar Singh, Seema Devi, Ravi Byahut, and Shraddha Raj. "Innovative Approaches to Radiation Delivery in Pediatric Oncology." International Journal of Medical and Biomedical Studies 9, no. 1 (2025): 205–11. https://doi.org/10.32553/ijmbs.v9i1.3034.

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Background: Radiation therapy plays a vital role in the treatment of pediatric malignancies. However, the developing anatomy and heightened radiosensitivity in children necessitate precision-focused approaches to minimize long-term toxicity. Recent advancements such as Volumetric Arc Therapy (VMAT), (IMRT), and 3DCRT offer enhanced tumor targeting with improved safety profiles. Aim: To compare the clinical outcomes and acute toxicity profiles of 3DCRT, IMRT, and VMAT in pediatric oncology patients undergoing radiation treatment. Methods: A prospective observational study was conducted at IGIMS

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Ivanov, Olivera, Aleksandra Milovančev, Borislava Petrović, et al. "Ultra-Hypofractionated vs. Moderate Fractionated Whole Breast Three Dimensional Conformal Radiotherapy during the COVID-19 Pandemic." Medicina 58, no. 6 (2022): 745. http://dx.doi.org/10.3390/medicina58060745.

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Background and Objectives: Reducing time of treatment during COVID-19 outbreaks has been recommended by the leading Radiation Oncology societies. Still minimizing radiation induced tissue toxicity is one of the most important issues in breast cancer patients. The study aimed to investigate compliance, clinical and dosimetry normal tissue toxicity, and cosmetic results between moderated and ultra-fractionated regimes for breast cancer patients during COVID-19 pandemic. Materials and Methods: This pilot prospective randomized study included 60 patients with early breast cancer after preserving s

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Baruah, Chiranjiv, Trishan Paul, Biswajit Sarma, Kankan Jyoti Deka, and Partha Pratim Patowory. "Hematological Toxicity in Carcinoma Cervix Patients Undergoing Concurrent Chemo Radiation Therapy or Radiation Therapy alone in a Tertiary Hospital of North East India: A Prospective Study." Asian Pacific Journal of Cancer Care 7, no. 4 (2022): 651–55. http://dx.doi.org/10.31557/apjcc.2022.7.4.651-655.

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Introduction: The current standard of treatment for locally advanced cancer of cervix is cisplatin based concurrent chemo radiation therapy followed by brachytherapy. Concurrent chemo radiotherapy causes acute hematological toxicities, which in turn leads to prolongation of therapy. Objective: The main purpose of our study, was to analyze the acute hematological toxicity in cervical cancer patients undergoing radiation or chemo radiation therapy. Materials and Methods: This is a hospital based observational study done at department of Radiation Oncology, Assam medical college and hospital. All

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Park, Joseph Junyong, Carla Hajj, Marsha Reyngold, et al. "Stereotactic body radiation vs. intensity-modulated radiation for unresectable pancreatic cancer." Journal of Clinical Oncology 35, no. 4_suppl (2017): 353. http://dx.doi.org/10.1200/jco.2017.35.4_suppl.353.

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353 Background: Stereotactic body radiation therapy (SBRT) is an emerging treatment option for unresectable pancreatic cancer, and may be more effective and less toxic than intensity modulated radiation therapy (IMRT). Methods: We retrospectively reviewed unresectable stage I-III pancreatic adenocarcinoma treated with SBRT (5 fractions, 30-33Gy) or IMRT (25-28 fractions, 45-56Gy with concurrent chemotherapy) between 2008-2016 at our institution. The groups were compared with respect to overall survival (OS), local failure (LF), distant failure (DF), any failure (AF), proportion of patients bec

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Zasadziński, Konrad, Mateusz Jacek Spałek, and Piotr Rutkowski. "Modern Dressings in Prevention and Therapy of Acute and Chronic Radiation Dermatitis—A Literature Review." Pharmaceutics 14, no. 6 (2022): 1204. http://dx.doi.org/10.3390/pharmaceutics14061204.

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Radiotherapy is an integral part of modern oncology, applied to more than half of all patients diagnosed with cancer. It can be used alone or in combination with surgery or chemotherapy. However, despite the high precision of radiation delivery, irradiation may affect surrounding healthy tissues leading to the development of toxicity. The most common and clinically significant toxicity of radiotherapy is acute and chronic radiation dermatitis, which could result in desquamation, wounds, nonhealing ulcers, and radionecrosis. Moreover, preoperative radiotherapy impairs wound healing after surger

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Radojevic, Marija Zivkovic, Aleksandar Tomasevic, Vesna Plesinac Karapandzic, Neda Milosavljevic, Slobodan Jankovic, and Marko Folic. "Acute chemoradiotherapy toxicity in cervical cancer patients." Open Medicine 15, no. 1 (2020): 822–32. http://dx.doi.org/10.1515/med-2020-0222.

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AbstractDuring radiotherapy treatment for cervical cancer, up to 84% of patients exhibit some form of acute radiation toxicity (ART). The primary aim of this clinical study is to determine the impact of angiotensin-converting enzyme (ACE) inhibitors, β-blockers and other risk factors such as the patient’s anatomical characteristics on ART emergence in patients with locally advanced cervical cancer treated by chemoradiotherapy. This is a combination of two nested case–control studies within the cohort of patients with locally advanced cervical cancer based on the analysis of potential risk fact

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Vu, T., S. Bosnic, G. Mitera, and J. P. Pignol. "36 Acute Skin Toxicity in Post-Mastectomy Radiation (PMR)." Radiotherapy and Oncology 76 (September 2005): S11. http://dx.doi.org/10.1016/s0167-8140(05)80197-5.

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Kopčalić, Katarina, Marina Nikitović, and Ivana Matić. "Association between serum cytokine levels and the development of acute radiotoxicity in prostate cancer patients." Medicinski podmladak 75, no. 3 (2024): 56–63. http://dx.doi.org/10.5937/mp75-45225.

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Radiotherapy plays a significant role in the multidisciplinary approach to treating prostate cancer patients. However, some of these patients may develop severe adverse effects after receiving radiotherapy that negatively affect their quality of life. Radiotoxicity may manifest in the lower gastrointestinal (GI) tract by damaging the rectum or bowel, or genitourinary (GU) tract, causing symptoms due to urethral, bladder or prostate damage. The probability of complications in normal tissue increases as the delivered radiation dose increases. However, there are patients with satisfactory dosimet

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Saputra, Made Gede Adi Surya, I. Wayan Sudira, Samsuri Samsuri, I. Made Merdana, Anak Agung Gde Oka Dharmayudha, and I. Gusti Ngurah Sudisma. "Evaluation of Acute Dermal Toxicity of Hibiscus Leaves as Simplicial Ointment on Albino Rats." Jurnal Medik Veteriner 6, no. 2 (2023): 216–29. http://dx.doi.org/10.20473/jmv.vol6.iss2.2023.216-229.

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Hibiscus is a plant that has been shown to contain substances that may be used as sunscreen to protect the skin from UV radiation. In terms of their potential as sunscreens, flavonoids, tannins, and quinone chemicals are crucial because they are antioxidants that can reduce the negative effects of UV radiation and boost photoprotective activity. This study aimed to investigate the acute dermal toxicity potential of hibiscus leaves simplicial ointment 40% on female albino rats. The evaluation method refered to The OECD Guideline for Testing of Chemicals – No. Test: 402, Acute Dermal Toxicity-Fi

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Jing, Yu, Fuxiang Zhou, Yang Wen-juan, Dai Jing, Xia Ling, and Wang Wen-bo. "IMRT-induced acute hepatic toxicity and analysis of the dose-volume effects in gastric cancer patients treated with postoperative radiation." Journal of Clinical Oncology 35, no. 15_suppl (2017): e15542-e15542. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e15542.

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e15542 Background: To investigate the postoperative-IMRT-induced hepatic toxicity in gastric cancer, and analyze the correlations between liver dose-volumetric parameters and acute hepatic toxicity, so as to give a dose-limitation suggestion for postoperative-IMRT in gastric cancer patients. Methods: Between June 2013 and June 2016, 67 patients with gastric cancer treated with post-operative adjuvant IMRT were reviewed. Prescribed dose was from 45Gy to 54Gy, in a daily fraction of 1.8–2.0 Gy. Dose constraints included: liver V30 < 40%, liver V40 < 30%, a mean dose of two kidneys < 18G

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Weidhaas, Joanne B., Donatello Telesca, Amar Upadhyaya Kishan, et al. "MicroRNA-based biomarkers of the radiation response in prostate cancer." Journal of Clinical Oncology 38, no. 6_suppl (2020): 163. http://dx.doi.org/10.1200/jco.2020.38.6_suppl.163.

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163 Background: Intermediate and high-risk prostate cancer can be cured with radiation (RT) to the prostate and pelvic lymph nodes with androgen deprivation therapy (ADT), but both acute and late toxicity of the GU and GI systems are common. There are no biomarkers predicting radiation outcomes, limiting the opportunity to best personalize prostate radiation therapy. Methods: A prospectively enrolled single arm trial for locally advanced prostate cancer patients (T1-T4N0-N1M0) treated with definitive RT (74Gy IMRT) plus ADT was studied. Biologic samples were available in 108 of 138 patients. T

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Santosh, Shubham, Roy Tanmoy, Rose Joseph Maria, and Jha Nisha. "A Retrospective Study on Comparison of Weekly versus Three Weekly Cisplatin Based Chemotherapy with Concurrent Radiotherapy in Treatment of Oropharyngeal Cancer." International Journal of Pharmaceutical and Clinical Research 15, no. 7 (2023): 477–87. https://doi.org/10.5281/zenodo.11642366.

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This retrospective study evaluated the toxicity and loco regional response of cisplatin-based chemotherapy administered in conjunction with radiation therapy for oropharyngeal carcinoma. Group A received 30mg/m2 intravenously every week, while Group B received 100mg/m2 every three weeks for 120 patients with histopathology-confirmed oropharyngeal cancer. Both groups were treated with 66–70 Gy of 2D radiation. Chemotherapy and radiation weekly evaluated acute toxicity. The study found that weekly and triweekly cisplatin-based chemotherapy could be used to treat oropharyngeal cancer. Both

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Ghareeb, A., K. Paramasevon, P. Mokool, H. van der Voet, and M. Jha. "Toxicity and survival of anal cancer patients treated with intensity-modulated radiation therapy." Annals of The Royal College of Surgeons of England 101, no. 3 (2019): 168–75. http://dx.doi.org/10.1308/rcsann.2018.0202.

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Introduction The definitive treatment of anal cancer with chemoradiotherapy spares abdominoperineal resection for salvage treatment but carries a high burden of toxicity. Intensity-modulated radiation therapy has been implemented to reduce toxicity, reduce treatment breaks and improve survival. However, large and long-term studies are lacking. We aimed to investigate the toxicities and long-term survival of anal cancer patients treated with intensity-modulated radiation therapy at James Cook University Hospital, Middlesbrough. Materials and methods We conducted a retrospective analysis of all

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Dalsania, Raj M., Kevin P. Shah, Eden Stotsky-Himelfarb, Sarah Hoffe, and Field F. Willingham. "Management of Long-Term Toxicity From Pelvic Radiation Therapy." American Society of Clinical Oncology Educational Book, no. 41 (March 2021): 147–57. http://dx.doi.org/10.1200/edbk_323525.

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Pelvic radiation therapy is an integral component in the treatment of various gastrointestinal, gynecologic, and genitourinary cancers. As survival rates from these malignancies improve, the prevalence of toxicity secondary to pelvic radiation has increased. Gastrointestinal toxicities are the most common complications and greatly impact quality of life. Toxicities can present in acute or late stages; although symptoms may be similar during both, the management may differ. Acute toxicities represent an inflammatory reaction in response to the radiation exposure, whereas late toxicities may ari

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Rjimati, Manelle, Z. Biaz, B. Amara, M. Elbiaze, MC Benjelloun, and M. Serraj. "Acute Post-Radiation Pneumonitis: A Case Report." Scholars Journal of Medical Case Reports 11, no. 04 (2023): 558–65. http://dx.doi.org/10.36347/sjmcr.2023.v11i04.036.

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Acute radiation pneumonitis is a rare cause of pneumonitis. The diagnosis is considered in the presence of respiratory symptoms that appear with recent thoracic exposure. We report the case of a 67-year-old patient followed for mediastinal lymphoma who presented an acute pneumonitis when she started her radiotherapy sessions. Two diagnostics were suspected: radiotherapy toxicity or metastatic origin. Acute post-radiation pneumonitis can be very serious if the diagnostic is delayed. The diagnosis of acute post-radiation pneumonitis constitutes a diagnosis of elimination of any pneumonitis with

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Ballas, Leslie K., Shelly X. Bian, Gus Miranda, and Siamak Daneshmand. "Radiosensitivity of orthotopic ileal neobladders." Journal of Clinical Oncology 33, no. 7_suppl (2015): 350. http://dx.doi.org/10.1200/jco.2015.33.7_suppl.350.

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350 Background: A prior report from our institution documented that Kock ileal reservoirs can tolerate doses of 45-50.4Gy. This study provides retrospective information on the radiosensitivity of orthotopic neobladders by reviewing the acute and late toxicity in patients who underwent post-operative radiotherapy following radical cystoprostatectomy with orthotopic ileal neobladder reconstruction. Methods: The USC bladder cancer database was queried for all patients who underwent cystoprostatectomy and neobladder reconstruction followed by adjuvant radiation therapy related to their bladder can

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Yassin, Radwa A., Ehab Mostafa, Khaled Naguib, Hany Ammar, and Diaa El Din Moussa. "Randomized prospective trial comparing two schedules of hypofractionated adjuvant radiotherapy 3 weeks against 1 week fractionation regimen in females with breast cancer." Egyptian Journal of Chest Diseases and Tuberculosis 73, no. 3 (2024): 316–23. http://dx.doi.org/10.4103/ecdt.ecdt_18_24.

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Purpose Acceleration of radiotherapy in five fractions for breast cancer can improve treatment accessibility, especially in low, middle-income countries and during pandemics. We report on acute toxicity after whole breast irradiation/chest wall irradiation±nodal irradiation, radiotherapy interruption and reported acute pneumonitis with an ultra-hypofractionation schedule compared to modest hypofractionation protocol during the coronavirus disease pandemic. Patients and methods Acute toxicity assessment using the RTOG acute toxicity scoring system. One of two specified doses was administered to

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Thomas, P. R., M. Tefft, G. J. D'Angio, and P. Norkool. "Acute toxicities associated with radiation in the second National Wilms' Tumor Study." Journal of Clinical Oncology 6, no. 11 (1988): 1694–98. http://dx.doi.org/10.1200/jco.1988.6.11.1694.

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Twenty-three of 303 patients (7.6%) entered into National Wilms' Tumor Study Number 2 (NWTS-2) with groups II, III, and IV disease experienced 26 toxic events thought to be related to radiotherapy (RT). The randomization between vincristine (VCR) plus dactinomycin (AMD) and the same two drugs plus doxorubicin (ADR) had a minimal effect on RT toxicity. Five (1.6%) fatalities were recorded and the surviving 18 patients recovered without discernible residua. Sixteen patients had hepatic, four had pulmonary, and three had cardiac toxicity. Hepatic toxicity was significantly more common when the ri

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Baranov, AE, GD Selidovkin, A. Butturini, and RP Gale. "Hematopoietic recovery after 10-Gy acute total body radiation." Blood 83, no. 2 (1994): 596–99. http://dx.doi.org/10.1182/blood.v83.2.596.596.

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Abstract Considerable data suggest that very high doses of acute total body radiation destroy most hematopoietic stem cells and that recovery is possible only after a bone marrow transplant. We review data from a radiation accident victim exposed to about 10-Gy or more acute total body radiation. Total dose and uniformity of distribution were confirmed by physical measurements (paramagnetic resonance), computer simulation, and biologic dosimetry (granulocyte kinetics and cytogenetic abnormalities). Treatment consisted of supportive measures, transfusions, and hematopoietic growth factors (gran

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Baranov, AE, GD Selidovkin, A. Butturini, and RP Gale. "Hematopoietic recovery after 10-Gy acute total body radiation." Blood 83, no. 2 (1994): 596–99. http://dx.doi.org/10.1182/blood.v83.2.596.bloodjournal832596.

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Considerable data suggest that very high doses of acute total body radiation destroy most hematopoietic stem cells and that recovery is possible only after a bone marrow transplant. We review data from a radiation accident victim exposed to about 10-Gy or more acute total body radiation. Total dose and uniformity of distribution were confirmed by physical measurements (paramagnetic resonance), computer simulation, and biologic dosimetry (granulocyte kinetics and cytogenetic abnormalities). Treatment consisted of supportive measures, transfusions, and hematopoietic growth factors (granulocyte-m

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Mehreen, Sana, Aalia Bashir, Muhammad Hisaan Anjum Qadri, and Ayesha Ahmad. "Frequency and Severity of Acute Perineal Skin Reactions in Rectal Cancer Patients at Completion of Preoperative Pelvic Radiotherapy." Pakistan Journal of Medical and Health Sciences 17, no. 2 (2023): 192–94. http://dx.doi.org/10.53350/pjmhs2023172192.

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Background: The rectum is the lower part of the colon. Its cancer is the third most common cancer worldwide. Aim: To determine frequency and severity of acute perineal skin reactions in rectal cancer patients at the completion of preoperative pelvic radiotherapy. Study Design: Descriptive case series. Methodology: Study conducted at the Department of Clinical Oncology, Shaukat Khanum Memorial Cancer Hospital Multan. Patients (n=96) were enrolled through non-probability consecutive sampling. All patients received neoadjuvant chemotherapy consisting of fluoropyrimidine and oxaliplatin, Radiother

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Minsky, B. D., J. A. Conti, Y. Huang, and K. Knopf. "Relationship of acute gastrointestinal toxicity and the volume of irradiated small bowel in patients receiving combined modality therapy for rectal cancer." Journal of Clinical Oncology 13, no. 6 (1995): 1409–16. http://dx.doi.org/10.1200/jco.1995.13.6.1409.

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PURPOSE To determine the relationship between acute gastrointestinal (GI) toxicity during the combined modality segment and the volume of small bowel in the pelvic radiation field in patients who receive either preoperative or postoperative therapy for rectal cancer. PATIENTS AND METHODS The patient population was derived from four consecutive phase I dose-escalation trials. Combined modality therapy included fluorouracil (5-FU), leucovorin ([LV] bolus daily x 5, days 1 and 29), and pelvic radiation. RESULTS Twenty patients who received postoperative therapy had a larger volume of small bowel

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Allali, Sofiane, and Youlia Kirova. "Radiodermatitis and Fibrosis in the Context of Breast Radiation Therapy: A Critical Review." Cancers 13, no. 23 (2021): 5928. http://dx.doi.org/10.3390/cancers13235928.

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Background: Radiation therapy has been progressively improved in order to maintain a satisfactory tumour response, while reducing toxicity. We will review the incidence of radiodermatitis and fibrosis according to the various radiation and fractionation techniques. We will then focus on the various methods used to manage, prevent, and quantify this toxicity. Method: More than 1753 articles were identified using the various search terms. We selected 53 articles to answer the questions addressed in this study according to criteria set in advance. Result: The literature reports lower acute toxici

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Lilleby, Oscar, Peter Meidahl Petersen, Gedske Daugaard, and Katharina Anne Perell. "Current evidence for moderate and ultra-hypofractionated radiation therapy in prostate cancer: a summary of the results from phase 3 randomised trials." Scandinavian Journal of Urology 58 (June 20, 2023): 21–27. http://dx.doi.org/10.2340/sju.v58.7719.

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Problem: A low α/β ratio for prostate cancer (PCa) compared to surrounding normal tissue theoretically implies therapeutical advantages with hypofractionated treatment. Data from large randomised control trials (RCTs) comparing moderate hypofractionated (MHRT, 2.4–3.4 Gray/fraction (Gy/fx)) and ultra-hypofractionated (UHRT, >5 Gy/fx) with conventionally fractionated radiation therapy (CFRT, 1.8–2 Gy/fx) and the possible clinical implications have been reviewed.Materials and method: We searched PubMed, Cochrane and Scopus for RCT comparing MHRT/UHRT with CFRT treatment of locally and/or loca

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Kumar, Prince, Subhadra Choubey, Harihar Nath Tiwari, Rajesh Kumar Singh, Seema Devi, and Ravi Byahut. "Role of Machine Learning in Predicting Radiation-Induced Toxicity." International Journal of Medical and Biomedical Studies 9, no. 1 (2025): 229–35. https://doi.org/10.32553/ijmbs.v9i1.3042.

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Background: Radiation therapy is fundamental to cancer treatment but frequently entails various levels of radiation-induced damage. Forecasting which people are most susceptible to substantial toxicity poses a problem owing to inter-individual heterogeneity. Machine learning (ML) methodologies provide a means to model intricate, nonlinear associations across clinical, dosimetric, and genetic factors, thereby facilitating enhanced toxicity prediction and individualized radiation planning. Objective: To assess the efficacy of machine learning models in forecasting radiation-induced toxicity in c

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Josifovski, Tatjana, Cane Tulic, Aleksandar Milosevic, and Ljiljana Radosevic-Jelic. "Acute and late toxicity in radical radiotherapy of prostate cancer." Srpski arhiv za celokupno lekarstvo 137, no. 1-2 (2009): 38–42. http://dx.doi.org/10.2298/sarh0902038j.

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Introduction. Although radical radiotherapy has proved to be a successful method in prostate cancer treatment, the conventional (box) technique can result in significant adverse events. Objective. The objective of our study was to estimate the frequency, type and severity of acute and late toxicity in radical radiotherapy of prostate cancer. Methods. In a clinical retrospective study, we included 283 patients with histologically confirmed prostate cancer. All our patients received radical, conventional radiotherapy using the four-field technique. The study was performed at the Radiotherapy Dep

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Langer, Corey J., Jonathan Harris, Eric M. Horwitz, et al. "Phase II Study of Low-Dose Paclitaxel and Cisplatin in Combination With Split-Course Concomitant Twice-Daily Reirradiation in Recurrent Squamous Cell Carcinoma of the Head and Neck: Results of Radiation Therapy Oncology Group Protocol 9911." Journal of Clinical Oncology 25, no. 30 (2007): 4800–4805. http://dx.doi.org/10.1200/jco.2006.07.9194.

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Purpose Recurrent squamous cell carcinoma of the head and neck (SCCHN) or new second primary tumor (SPT) in a previous radiation field, if not curable by surgery or radiation, is almost always fatal. Chemotherapy alone yields a median survival time (MST) of no more than 10 months and 1-year overall survival (OS) of 35% at best. Concurrent reirradiation and chemotherapy is an alternative strategy. Patients and Methods Eligibility for Radiation Therapy Oncology Group (RTOG) protocol 9911 stipulated recurrent SCCHN or SPT in a previous radiation field. Patients received twice-daily radiation (1.5

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Molinier, Victoire, Florence Huguet, Marcos Ballester, et al. "Outcomes after Radiation Therapy for HIV Positive Patients with Invasive Cervical Cancer." Cancer and Clinical Oncology 7, no. 1 (2018): 12. http://dx.doi.org/10.5539/cco.v7n1p12.

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Objective: To assess tolerance, local control, and survival outcomes for HIV (human immunodeficiency virus) positive patients with locally advanced cervical cancer (CC) treated with external beam radiation therapy (EBRT) and/or brachytherapy from an Assistance Publique - Hôpitaux de Paris (APHP) retrospective cohort.Methods: Between 2000 and 2014, 28 HIV positive patients presenting with a non-metastatic CC were treated in one of the five APHP radiation therapy centers. Fifteen patients (54%) underwent primary surgery. Twenty-four patients (88%) received EBRT, with concurrent chemotherapy in 2

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Tiwari, Harihar Nath, Subhadra Choubey, Ravi Byahut, Rajesh Kumar Singh, and Seema Devi. "Management Complexity of Elderly Cancer Patients: the Potential of Radiation Oncology." International Journal of Medical and Biomedical Studies 9, no. 2 (2025): 6–13. https://doi.org/10.32553/ijmbs.v9i2.2968.

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Background: Age-related physiological changes, various comorbidities, and higher treatment toxicity make elderly cancer patients distinctive. Radiation therapy is important in curative and palliative contexts, although its effects on clinical outcomes need greater study. Methods: This retrospective analysis examined 160 elderly cancer patients (?60 years) who received radiation therapy at PMCH from April 2022 to March 2024. Assessments included patient demographics, cancer kind, disease stage, treatment intent, radiation procedures, toxicity profiles, and clinical results. OS and PFS were anal

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Laskar, Sarbani Ghosh, and Prahlad H. Yathiraj. "Acute radiation toxicity in head and neck and lung malignancies." South Asian Journal of Cancer 03, no. 01 (2014): 005–7. http://dx.doi.org/10.4103/2278-330x.126499.

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Koh, W., K. Lim, and J. Tey. "Hypofractionated Breast Radiation Therapy: Acute Toxicity in Asian Skin Types." International Journal of Radiation Oncology*Biology*Physics 84, no. 3 (2012): S223. http://dx.doi.org/10.1016/j.ijrobp.2012.07.580.

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Momm, Felix, Christian Weißenberger, Susanne Bartelt, and Michael Henke. "Moist Skin Care Can Diminish Acute Radiation-Induced Skin Toxicity." Strahlentherapie und Onkologie 179, no. 10 (2003): 708–12. http://dx.doi.org/10.1007/s00066-003-1142-9.

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Kissel, CG, and RP Mistretta. "Acute radiodermatitis following radiotherapy for classic Kaposi's sarcoma." Journal of the American Podiatric Medical Association 83, no. 8 (1993): 442–46. http://dx.doi.org/10.7547/87507315-83-8-442.

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There is a high incidence of radiation toxicity associated with Kaposi's sarcoma. The authors review acute radiodermatitis and present a case where it occurred in the foot following radiotherapy for classic Kaposi's sarcoma.

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Morris, M. M., and S. N. Powell. "Irradiation in the setting of collagen vascular disease: acute and late complications." Journal of Clinical Oncology 15, no. 7 (1997): 2728–35. http://dx.doi.org/10.1200/jco.1997.15.7.2728.

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PURPOSE Based on reports of greater toxicity from radiation therapy, collagen vascular diseases (CVDs) have been considered a contraindication to irradiation. We assessed the complications of radiation therapy in patients with CVD. PATIENTS AND METHODS A total of 209 patients with documented CVD were irradiated between 1960 and 1995. One hundred thirty-one had rheumatoid arthritis (RA), 25 had systemic lupus erythematosus (SLE); 17 had polymyositis or dermatomyositis; 16 had scleroderma; eight had ankylosing spondylitis; five had juvenile RA; three had discoid lupus erythematosus; and four had

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Dubail, Maxime, Sophie Heinrich, Lucie Portier, et al. "Lung Organotypic Slices Enable Rapid Quantification of Acute Radiotherapy Induced Toxicity." Cells 12, no. 20 (2023): 2435. http://dx.doi.org/10.3390/cells12202435.

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To rapidly assess healthy tissue toxicities induced by new anti-cancer therapies (i.e., radiation alone or in combination with drugs), there is a critical need for relevant and easy-to-use models. Consistent with the ethical desire to reduce the use of animals in medical research, we propose to monitor lung toxicity using an ex vivo model. Briefly, freshly prepared organotypic lung slices from mice were irradiated, with or without being previously exposed to chemotherapy, and treatment toxicity was evaluated by analysis of cell division and viability of the slices. When exposed to different do

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Perisamy, Kannan, Ashutosh Mukherji, Saravanan Kandasamy, and K. Sathyanarayan Reddy. "Acute toxicity of concomitant boost radiation therapy by volumetric-modulated arc therapy in head and neck cancers." Journal of Radiotherapy in Practice 16, no. 4 (2017): 423–30. http://dx.doi.org/10.1017/s1460396917000334.

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AbstractIntroductionVolumetric-modulated arc therapy (VMAT) is an advanced form of intensity-modulated radiation therapy that reduces treatment time without compromising plan quality. This study assessed acute toxicities in patients having carcinomas of oropharynx, larynx and hypopharynx treated with concomitant boost radiation therapy by VMAT.Materials and methodsIn this study, 30 patients of stages II–IVA disease were treated with concomitant boost radiation therapy using VMAT and those with stages III and IV also received concurrent chemotherapy with cisplatin 100 mg/m2 weekly thrice for tw

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Moningi, Shalini, Jaffer A. Ajani, Brian D. Badgwell, et al. "The effect of IMRT on acute toxicity in patients with gastric cancer treated with preoperative chemoradiation." Journal of Clinical Oncology 37, no. 4_suppl (2019): 153. http://dx.doi.org/10.1200/jco.2019.37.4_suppl.153.

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153 Background: Two trials are currently investigating preoperative chemoradiation (CRT) for localized gastric adenocarcinoma. However, radiation therapy (RT) can be associated with relatively high rates of acute toxicity. Newer techniques, such as intensity modulated RT (IMRT), could reduce toxicity by reducing radiation dose to normal structures. Our goal was to compare rates of toxicity and toxicity-related events in patients treated with IMRT compared to 3D conformal RT (3DCRT). Methods: The records of 202 gastric cancer patients treated with preoperative intent RT at our institution from

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