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Journal articles on the topic 'ACVB'

Author: Grafiati
Published: 4 June 2021
Last updated: 13 February 2022

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1

Zheng, Y. Z., G. P. Wang, N. Hong, J. F. Zhou, Z. K. Yang, and N. Hong. "First Report of Actinidia virus A and Actinidia virus B on Kiwifruit in China." Plant Disease 98, no. 11 (November 2014): 1590. http://dx.doi.org/10.1094/pdis-04-14-0420-pdn.

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At present, two viruses affecting kiwifruit (Actinidia spp.), Actinidia virus A (AcVA) and Actinidia virus B (AcVB), both belonging to the genus Vitivirus in the family Betaflexiviridae, have been reported from New Zealand (2). The infected trees showed leaf vein chlorosis, flecking, and ringspots. China is the largest commercial kiwifruit producer. During field investigations in the growing season of 2013, symptoms of leaf chlorosis or ringspots, similar to those caused by AcVA and AcVB (1), were observed on some kiwifruit (Actinidia chinensis) plants in Hubei Province in the central China. Leaf samples were collected from three symptomatic and two symptomless plants of two A. chinensis cultivars. Total nucleic acids were extracted from the samples using a CTAB-based protocol described by Li et al. (3) and used as template in RT-PCR for the detection of AcVA and AcVB. Each virus was detected using two sets of primers reported by Blouin et al. (1). Primer sets AcVA 1F/1R and AcVA5F/5R were used for the AcVA detection, and AcVB1F/1R and AcVB5F/Viti3'R were used for the AcVB detection. AcVA was detected in three symptomatic plants (ID: Ac-HN-1, Ac-HN-3, and Ac-HN-5), and AcVB was detected in two symptomatic plants (ID: Ac-HN-1 and Ac-HN-3) and in one symptomless plant (ID: Ac-HN-2). Neither virus was detected in the second symptomless plant (ID: Ac-HN-4). Samples Ac-HN-1 and Ac-HN-3 had mixed infection of AcVA and AcVB, and sample Ac-HN-2 had the latent infection of AcVB. The sequenced 283-bp RT-PCR amplicons of the replicase-encoding gene from AcVA isolates AC-HN-3 and AC-HN-5 using AcVA1F/1R shared 90.8% nucleotide (nt) identity with the corresponding sequence of the New Zealand AcVA isolate (GenBank Accession No. JN427014.1). The 269-bp fragments of the RNA-binding protein-encoding gene obtained by using AcVA5F/5R shared 85.5 to 85.9% nt identities with the corresponding sequence of JN427014.1. The AcVB5F/Viti3'R products of 365 to 369 bp from three AcVB isolates shared 85.5 to 88.6% nt identities with the corresponding sequence of the New Zealand AcVB isolate. The representative sequences were submitted to GenBank with accession numbers KJ696776 and KJ696777 for the 269-bp fragments of AcVA-HN-1 and AcVA-HN-3, and KJ696778 and KJ696779 for the 365-bp and 369-bp fragments of AcVB-HN-1 and AcVB-HN-2, respectively. In addition, 12 and 14 out of 42 kiwi samples (excluding HN-1 to HN-5) collected randomly were positive for AcVA and AcVB as detected by RT-PCR. Meanwhile, the sample affected by AcVA-HN-5 was subjected to deep sequencing of the small RNAs (sRNAs) for complete survey of the infecting viruses. De novo assembly of sRNAs generated four sequence contigs, with lengths ranging from 161 to 285 nt, matching to ORFs 1 to 3 of the genome of the New Zealand AcVA isolate with significant nucleotide (91 to 95%) and amino acid (80 to 94%) similarities, and some other contigs from a new virus (unpublished). The result further confirmed AcVA infection in the kiwi plant. To our knowledge, this is the first report of both AcVA and AcVB outside of New Zealand. The Chinese isolates of the two viruses are distinct from those reported from New Zealand. The results provide valuable information for improving the viral sanitary status of the kiwifruit germplasm in China. References: (1) A. G. Blouin et al. Arch. Virol. 157:713, 2012. (2) A. G. Blouin et al. J. Plant Pathol. 95:221, 2013. (3) R. Li et al. J. Virol. Methods 154:48, 2008.
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2

Zhao, Lei, Wen Yang, Yuanle Zhang, Zhanmin Wu, Qiao-Chun Wang, and Yunfeng Wu. "Occurrence and Molecular Variability of Kiwifruit Viruses in Actinidia deliciosa ‘Xuxiang’ in the Shaanxi Province of China." Plant Disease 103, no. 6 (June 2019): 1309–18. http://dx.doi.org/10.1094/pdis-09-18-1570-re.

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Kiwifruit (Actinidia spp.) is an economically substantial fruit crop with China the main producer. China is the primary source of wild kiwifruit and the largest producer of kiwifruit in terms of both production and planting area, and Shaanxi province is the largest kiwifruit producer in China. Previous studies reported presence of kiwifruit viruses in Actinidia chinensis. In this study, six viruses were identified in kiwifruit ‘Xuxiang’ (A. deliciosa) in Shaanxi, China. The incidence, distribution, and genetic diversity of these viruses were studied. The results showed that Actinidia virus A (AcVA), Actinidia virus B (AcVB), Actinidia chlorotic ringspot-associated virus (AcCRaV), cucumber mosaic virus (CMV), apple stem grooving virus (ASGV), and potato virus X (PVX) were the main viruses infecting Xuxiang kiwifruit in Shaanxi, China. Incidence of the various viruses with both single and multiple infection varied with different kiwifruit-growing counties. For single virus infection, the highest and the lowest numbers of samples infected were about 22 for AcCRaV and 0 for AcVB in Meixian out of 170 samples, 12 for AcVA and 0 for CMV in Zhouzhi out of 120 samples, 10 for AcVA and 0 for AcVB, AcCRaV, ASGV, PVX, and CMV in Yangling out of 70 samples, and 8 for AcCRaV and CMV and 0 for AcVA, AcVB, ASGV, and PVX in Hanzhong out of 80 samples, respectively. Samples which were multiply infected with two or more viruses were also detected. Analysis of the phylogenetic tree of these viruses showed some genetic variability in the AcVA, AcVB, and AcCRaV isolates of Shaanxi kiwifruit. There was no obvious molecular variation in the coat protein genes of ASGV, CMV, and PVX virus isolates from Shaanxi kiwifruit. The present study is the first large-scale survey of kiwifruit viruses in Shaanxi, China. To our knowledge, this is the first report of PVX infecting kiwifruit and the first report of molecular variability of AcVA, AcVB, and AcCRaV. These results provide important data for studying the genetic evolution of AcVA, AcVB, AcCRaV, ASGV, CMV, and PVX.
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3

SILALAHI, DARWIN, I. GEDE PUTU WIRAWAN, and MADE SRITAMIN. "Transformasi Genetik Tanaman Kentang (Solanum tuberosum L.) dengan Gen acvB Menggunakan Vektor Agrobacterium tumefaciens." Agrotrop : Journal on Agriculture Science 11, no. 1 (May 31, 2021): 63. http://dx.doi.org/10.24843/ajoas.2021.v11.i01.p07.

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Agrobacterium tumefaciens Mediated Genetic Transformation of acvB Gene in Potato (Solanum tuberosum L.). Genetic transformations are now routinely applied to plant mediated by Agrobacterium tumefaciens as the most convenient technique. This study aimed to prove the success of A. tumefaciens mediated genetic transformation in potato. A. tumefaciens LBA (pBI 121) and explant of potato shoot were used in this study. Explants were grown in vitro on Murashige and Skoog media. Transformation was implemented using smear technique by smearing A. tumefaciens to injured explant. Experimental groups consisted of two groups: control group which did not receive transformation treatment and treatment group receiving transformation treatment. Explant growth was observed through the presence of shoots, branches and the shoot height. Explants in the treatment group resulted in a higher number of shoots, branches, and shoot heights compared to control. Phenol compounds appear in explant epidermal tissue, indicating the wounds produced by A. tumefaciens infection, thus the gene predicted to be transformed. Identification by PCR is needed to prove the existence of the acvB gene in potato plants genome, using acvB specific PCR primer as the marker, such as (5?-CCCT CTAG AGAC CCGC GCCA AGGCG-3?) and (5?CGCG TCGA CCTT GTCG GAAAG -3?) with 540-bp in base pair size produced.
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4

Coiffier, B., C. Gisselbrecht, R. Herbrecht, H. Tilly, A. Bosly, and N. Brousse. "LNH-84 regimen: a multicenter study of intensive chemotherapy in 737 patients with aggressive malignant lymphoma." Journal of Clinical Oncology 7, no. 8 (August 1989): 1018–26. http://dx.doi.org/10.1200/jco.1989.7.8.1018.

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From July 1984 to September 1987, 737 patients with aggressive malignant lymphoma (ML) were treated by an intensive regimen (LNH-84) comprising three or four courses of doxorubicin, 75 mg/m2; cyclophosphamide, 1,200 mg/m2; vindesine, 2 mg/m2 x 2; bleomycin, 10 mg x 2; and prednisolone, 60 mg/m2 x 5 (ACVB), consolidation with high-dose methotrexate, ifosfamide, etoposide, asparaginase, and cytarabine, and a randomized late intensification with two courses of cytarabine, cyclophosphamide, teniposide, bleomycin, and prednisone (AraCVmB). Four hundred forty-two patients had intermediate-grade ML, 221 highgrade ML, and 74 unclassified ML. Most of the patients had advanced disease: stage IIE (23%), III (13%), or IV (47%); 38% disseminated nodes; 38% two or more extranodal sites; and 41% a tumoral mass greater than 10 cm. Five hundred fifty-three patients (75%) went into complete remission (CR), 63 (9%) into partial remission, 62 (8%) failed to respond, and 59 (8%) died during ACVB courses, 17 of them from progression of the disease. With a median follow-up of 23 months, the estimated 2-year overall survival time to failure (TTF), and time to relapse (TTR) survival are 67%, 56%, and 67%, respectively. Patients receiving a late intensification had the same relapse rate as the other patients. A persistent fibronecrotic mass was found in 150 patients (20%) and did not influence the relapse rate. Toxicity was mainly neutropenia and infection during the ACVB courses, with 40 patients (5%) dying from septic complications while responding to treatment. Fifty-three percent of the patients had a neutropenia less than 0.500 x 10(9)/L, 58% fever (6% grade 4), and 49% a documented infection (8% grade 4). These results obtained with the LNH-84 regimen demonstrate that this therapeutic scheme is an effective treatment for aggressive ML.
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5

Luska, G., Ph Hendrickx, A. Kuhl, and P. Lichtlen. "Peripher venöse digitale Subtraktionsangiographie (DSA) zur Kontrolle von aortokoronaren Venenbypassgrafts (ACVB)." RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren 142, no. 01 (January 1985): 35–40. http://dx.doi.org/10.1055/s-2008-1052596.

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6

Groenewold, Maike K., Stefanie Hebecker, Christiane Fritz, Simon Czolkoss, Milan Wiesselmann, Dirk W. Heinz, Dieter Jahn, Franz Narberhaus, Meriyem Aktas, and Jürgen Moser. "Virulence ofAgrobacteriumtumefaciensrequires lipid homeostasis mediated by the lysyl-phosphatidylglycerol hydrolase AcvB." Molecular Microbiology 111, no. 1 (November 14, 2018): 269–86. http://dx.doi.org/10.1111/mmi.14154.

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7

Gede Putu Wirawan, I., and Mineo Kojima. "Distribution of a Chromosomal Virulence Gene,acvB, ofAgrobacterium tumefaciensamong Various Bacteria." Bioscience, Biotechnology, and Biochemistry 60, no. 1 (January 1996): 50–53. http://dx.doi.org/10.1271/bbb.60.50.

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8

Vinuesa, Pablo, Frauke Neumann-Silkow, Cristina Pacios-Bras, Herman P. Spaink, Esperanza Martínez-Romero, and Dietrich Werner. "Genetic Analysis of a pH-Regulated Operon from Rhizobium tropici CIAT899 Involved in Acid Tolerance and Nodulation Competitiveness." Molecular Plant-Microbe Interactions® 16, no. 2 (February 2003): 159–68. http://dx.doi.org/10.1094/mpmi.2003.16.2.159.

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Rhizobium tropici CIAT899 is highly acid tolerant and a good competitor for Phaseolus vulgaris nodule occupancy at low pH values. Using Tn5 mutagenesis, we identified an operon required for acid tolerance and nodulation competitiveness. The insertion was mapped to the 5′ end of atvA, encoding a product with high sequence identity to the agrobacterial AcvB virulence protein. Complementation analyses indicated that atvA is an ortholog of acvB, both genes being required for acid tolerance. A Ser/Ala substitution in the LIPASE_SER motif of AtvA resulted in an acid sensitive Fix+ but very poorly competing strain, demonstrating that Ser-313 is essential for AtvA function. atvA is the second gene in an operon that is transcriptionally upregulated by acid shock. The acid-responsive promoter was mapped to a 469-bp intergenic region located upstream of lpiA, the first gene in the operon. lpiA-like genes are found in several α, β, and γ Proteobacteria that interact with eukaryotic host cells, and they are predicted to encode membrane proteins related to the FmtC/MprF family from low G+C Firmicutes. The latter proteins are involved in resistance to cationic antimicrobial peptides. A nonpolar deletion in lpiA caused a sevenfold decrease in relative nodulation competitiveness.
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9

Goette, A., J. Mittag, A. Friedl, H. Busk, M. S. Jepsen, J. C. Geller, J. Hann, C. Huth, and H. U. Klein. "Möglichkeiten der temporären atrialen Stimulation zur Verhinderung von Vorhofflimmern nach ACVB-OP." Herzschrittmachertherapie und Elektrophysiologie 9, S1 (February 1998): 99–100. http://dx.doi.org/10.1007/bf03042456.

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10

Neumann, T., W. Ehrlich, J. Sperzel, A. Kimmel, R. Willems, W. P. Klövekorn, and J. Neuzner. "Biatriale Stimulation zur Suppression von Vorhofflimmern nach ACVB Operation: Ergebnisse einer prospektiv, randomisierten Untersuchung." Herzschrittmachertherapie und Elektrophysiologie 11, S1 (January 2000): 91–92. http://dx.doi.org/10.1007/bf03042543.

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11

FUJIWARA, Atushi, Hisao TAKAMURA, Parimal MAJUMDER, Hisashi YOSHIDA, and Mineo KOJIMA. "Functional Analysis of the Protein Encoded by the Chromosomal Virulence Gene(acvB) of Agrobacterium tumefaciens." Japanese Journal of Phytopathology 64, no. 3 (1998): 191–93. http://dx.doi.org/10.3186/jjphytopath.64.191.

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12

Kang, Hi Wan, I. Gede Putu Wirawan, and Mineo Kojima. "Cellular Localization and Functional Analysis of the Protein Encoded by the Chromosomal VirulenceGene(acvB) ofAgrobacterium tumefaciens." Bioscience, Biotechnology, and Biochemistry 58, no. 11 (January 1994): 2024–32. http://dx.doi.org/10.1271/bbb.58.2024.

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13

Coiffier, B. "Fourteen years of high-dose CHOP (ACVB regimen): Preliminary conclusions about the treatment of aggressive-lymphoma patients." Annals of Oncology 6, no. 3 (March 1995): 211–17. http://dx.doi.org/10.1093/oxfordjournals.annonc.a059149.

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14

Yamamoto, Y., Y. Kobayashi, Y. Yoshimoto, and K. Okuda. "104 EXPRESSION OF ACTIVIN A AS A LOCAL REGULATOR IN THE BOVINE OVIDUCT." Reproduction, Fertility and Development 27, no. 1 (2015): 145. http://dx.doi.org/10.1071/rdv27n1ab104.

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Activin (ACV) is known as a local regulator of several reproductive functions including follicular development and implantation in mammals. ACVA is a glycopeptide belonging to the transforming growth factor β superfamily, and is a homodimer of inhibin ßA (INHBA) subunits. Follistatin (FST), an ACV-specific binding protein, inhibits ligand-receptor binding. ACV receptor (ACVR) is a hetero-tetramer consisting of 2 kinds of protein, ACVR1 or ACVR1B and ACVR2A or ACVR2B. The oviduct provides an optimal environment for sperm capacitation, fertilization, and early embryonic development. Previous reports have demonstrated that ACVRs were expressed in bovine oocytes and embryos, and that early embryonic development is facilitated by ACVA in vitro. ACVA produced by the bovine oviduct may affect gametes and embryos as well as oviductal cells as a local regulator in cow. Bovine oviductal samples were classified into 6 stages of the oestrous cycle (day of ovulation; Days 2–3 after ovulation; Days 5–6; Days 8–12; Days 15–17; Days 19–21). We examined (1) protein expression of ACVA and FST in oviductal fluid collected from the ampulla and isthmus, (2) mRNA expression of INHBA and FST in the ampullary and isthmic oviductal tissues during the oestrous cycle, (3) the effects of oestradiol-17β (E2: 0.1, 1, 10 nM) and progesterone (P4: 1, 10, 100 nM) on mRNA expressions of INHBA and FST in cultured oviductal epithelial cells isolated from the ampulla and isthmus, and (4) mRNA expression of ACVRs in tissues and in cultured epithelial and stromal cells. The main findings were as follows: (1) Both ACVA and FST were detected throughout the oestrous cycle in the oviductal fluid of the ampulla and isthmus. (2) INHBA expression was higher in the isthmus than in the ampulla. FST expression in the ampulla was lowest at peri-ovulation, INHBA expression in the isthmus was highest on the day of ovulation and FST in the isthmus during Days 2–6 was highest. Because an increase of ACVA production and a decrease of FST production raise ACVA bioactivity, ACVA seems to be most active at peri-ovulation in both the ampulla and isthmus. (3) In the cultured isthmic oviductal epithelial cells, 10 nM E2 significantly stimulated INHBA expression, but tended to suppress FST expression. Therefore, the bioactivity of ACVA seems to be controlled by E2 during the oestrous cycle in the isthmus. (4) The expression of ACVR1B and ACVR2A was clearly detected in the tissues as well as in cultured epithelial and stromal cells. The overall findings suggest that ACVA secreted into oviductal fluid plays an important role in oviductal functions, including fertilization in the ampulla and sperm motility and viability in the isthmus. It is also suggested that ACVA acts on both epithelial and stromal cells as a local regulator of cellular functions, such as cellular proliferation and secretion in the cow.
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15

Böckelmann, Irina, Robert Pohl, George Awad, Sabine Darius, Jens Wippermann, Beatrice Thielmann, and Maximilian Scherner. "Stressinduzierte vegetative Antwortreaktion des ärztlichen Personals bei herzchirurgischen Eingriffen." Zentralblatt für Arbeitsmedizin, Arbeitsschutz und Ergonomie 71, no. 5 (June 25, 2021): 220–33. http://dx.doi.org/10.1007/s40664-021-00436-8.

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Zusammenfassung Hintergrund Chirurgen erleben in ihrem Arbeitsalltag eine hohe psychische Belastung. Die Herzfrequenzvariabilität (HRV) ist als vegetativer Beanspruchungsparameter zur Erfassung von psychischen Belastungen etabliert. Eine geringe HRV ist ein Indikator für hohen Stress. Ziel der Arbeit Ziel der Querschnittsstudie war es, die Aktivierung des autonomen Nervensystems als stressinduzierte Antwortreaktion und das Stressniveau bei chirurgisch tätigen Ärzten verschiedener Qualifikationsstufen während ihrer Tätigkeit anhand der HRV zu untersuchen. Material und Methoden Es wurde die HRV aus 31 EKG-Aufnahmen von 5 freiwilligen, klinisch gesunden männlichen Herzchirurgen während 25 aortokoronarer Bypassoperationen (ACB-OP) und der Stationsarbeit analysiert. Als Einschlusskriterium galt die Tätigkeit als Assistenzarzt bzw. Oberarzt, die berechtigt sind, herzchirurgische Eingriffe durchzuführen. Relevante Medikamente und Vorerkrankungen, die den Herzrhythmus beeinflussen und die Häufigkeit von Extrasystolen im EKG (> 1 % ) waren Ausschlusskriterien. Die Tätigkeit während der Operation und Nicht-Operationsphase wurde schriftlich dokumentiert. Bei der statistischen Auswertung kamen der Mann-Whitney-U-Test und das Allgemeine Lineare Modell mit der Anpassung nach Bonferroni unter Berücksichtigung der ärztlichen Funktion und der Art der Tätigkeit während der Operation als Kovariaten zur Anwendung. Ergebnisse Eine reduzierte HRV während der ACVB-OP fand sich bei den zeitbezogenen Parametern RMSSD (Root Mean Square of Successive Differences) und pNN50 (Prozentsatz der NN-Intervalle mit mindestens 50 ms Abweichung vom vorausgehenden NN-Intervall), dem frequenzbezogenen Parameter LF (Low Frequency) power sowie dem nichtlinearen Kurzzeitvariabilitätsparameter SD1 (Standard Deviation oder die Breite der Punktwolke) für Assistenzärzte im Vergleich zu den Oberärzten. 50,8 % der Arbeitszeit war im OP für die Assistenzärzte als hohe Stresssituation gekennzeichnet (Oberärzte: 11,7 %; p = 0,015). Die Beanspruchungsreaktion bei der Stationsarbeit zeigte sich als deutlich geringer ausgeprägt, wobei diese in beiden Gruppen vergleichbar war. Diskussion Es zeigt sich eine höhere stressinduzierte Antwortreaktion während der ACB-OP bei Assistenzärzten im Vergleich zu Oberärzten. Es sollten frühzeitig präventive und gesundheitsfördernde Maßnahmen bei hoher arbeitsbezogener Stressbelastung bei chirurgisch tätigen Ärzten insbesondere in der Facharzt-Weiterbildungsphase eingeleitet werden.
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16

Kalogeraki, V. S., and S. C. Winans. "The octopine-type Ti plasmid pTiA6 of Agrobacterium tumefaciens contains a gene homologous to the chromosomal virulence gene acvB." Journal of bacteriology 177, no. 4 (1995): 892–97. http://dx.doi.org/10.1128/jb.177.4.892-897.1995.

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17

Winterfeld, H. J., Almuth Risch, H. Siewert, D. Strangfeld, J. Kruse, U. Engelmann, and H. Warnke. "Der Einfluß der konzentrativen Entspannung auf Blutdruck und Hämodynamik bei hypertonen Patienten mit koronarer Herzkrankheit und aortokoronarer Venenbypassoperation (ACVB)." Physikalische Medizin, Rehabilitationsmedizin, Kurortmedizin 43, no. 04 (1991): 220–24. http://dx.doi.org/10.1055/s-2008-1062184.

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18

Fiedler, C., J. Osterbrink, H. Mayer, and G. C. M. Evers. "Die Inzidenz der akuten postoperativen Verwirrtheit bei kardiochirugischen Patienten nach einem aorto-koronaren-Venenbypass (ACVB) und / oder eines Herzklappenersatzes." intensiv 10, no. 06 (November 2002): 275–80. http://dx.doi.org/10.1055/s-2002-35448.

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19

Coiffier, B., PA Bryon, M. Ffrench, M. Blanc, C. Sebban, F. Berger, and JJ Viala. "Intensive chemotherapy in aggressive lymphomas: updated results of LNH- 80 protocol and prognostic factors affecting response and survival." Blood 70, no. 5 (November 1, 1987): 1394–99. http://dx.doi.org/10.1182/blood.v70.5.1394.1394.

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Abstract One hundred patients with aggressive malignant lymphomas treated with the LNH-80 regimen were evaluated for long-term survival and pretreatment characteristics predictive of response and survival. LNH- 80 consists of three intensive courses of adriamycin cyclophosphamide vindesine bleomycin (ACVB) followed by sequential consolidation and final intensification. Eighty-four patients went into complete remission (CR), eight had a partial response (PR), three failed to respond, and five died during induction. Twenty-three patients (27%) relapsed, in two of whom a prolonged second remission was obtained. Sixty-three patients are currently alive, two of them with disease. Four patients died in CR. Median survival and median freedom from relapse survival were not reached with a median follow-up of 4 1/2 years. Characteristics negatively associated with response in multivariate analysis were: poor performance status, bone marrow involvement, and two or more extranodal sites of disease. Duration of CR was associated with splenic involvement. Three characteristics were negatively associated with survival in multivariate analysis: age, high grade subtypes, and bone marrow involvement.
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20

Coiffier, B., PA Bryon, M. Ffrench, M. Blanc, C. Sebban, F. Berger, and JJ Viala. "Intensive chemotherapy in aggressive lymphomas: updated results of LNH- 80 protocol and prognostic factors affecting response and survival." Blood 70, no. 5 (November 1, 1987): 1394–99. http://dx.doi.org/10.1182/blood.v70.5.1394.bloodjournal7051394.

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One hundred patients with aggressive malignant lymphomas treated with the LNH-80 regimen were evaluated for long-term survival and pretreatment characteristics predictive of response and survival. LNH- 80 consists of three intensive courses of adriamycin cyclophosphamide vindesine bleomycin (ACVB) followed by sequential consolidation and final intensification. Eighty-four patients went into complete remission (CR), eight had a partial response (PR), three failed to respond, and five died during induction. Twenty-three patients (27%) relapsed, in two of whom a prolonged second remission was obtained. Sixty-three patients are currently alive, two of them with disease. Four patients died in CR. Median survival and median freedom from relapse survival were not reached with a median follow-up of 4 1/2 years. Characteristics negatively associated with response in multivariate analysis were: poor performance status, bone marrow involvement, and two or more extranodal sites of disease. Duration of CR was associated with splenic involvement. Three characteristics were negatively associated with survival in multivariate analysis: age, high grade subtypes, and bone marrow involvement.
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21

Hirai, Yuka, Noriko Kawabe, Yoshiko Tsuda, Satoru Miyamoto, and Seigo Iwakawa. "Effect of 2-Methoxyestradiol, Buthionine Sulfoximine and Hydrogen Peroxide on the Viability of Renal Carcinoma Cell Lines (ACHN and ACVB)." Biological & Pharmaceutical Bulletin 29, no. 5 (2006): 1064–67. http://dx.doi.org/10.1248/bpb.29.1064.

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22

Dumontet, Charles, Nicolas Mounier, Jean Nicolas Munck, André Bosly, Frank Morschauser, Daniele Simon, Gérald Marit, et al. "Factors predictive of early death in patients receiving high-dose CHOP (ACVB regimen) for aggressive non-Hodgkin's lymphoma: a GELA study." British Journal of Haematology 118, no. 1 (July 2002): 210–17. http://dx.doi.org/10.1046/j.1365-2141.2002.03565.x.

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23

Gede Putu Wirawan, I., and Mineo Kojima. "A Chromosomal Virulence Gene (acvB) Product ofAgrobacterium tumefaciensThat Binds to a T-Strand to Mediate Its Transfer to Host Plant Cells." Bioscience, Biotechnology, and Biochemistry 60, no. 1 (January 1996): 44–49. http://dx.doi.org/10.1271/bbb.60.44.

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Suzutani, Tatsuo, Ken Ishioka, Erik De Clercq, Kei Ishibashi, Hisatoshi Kaneko, Toshihiko Kira, Koh-ichi Hashimoto, et al. "Differential Mutation Patterns in Thymidine Kinase and DNA Polymerase Genes of Herpes Simplex Virus Type 1 Clones Passaged in the Presence of Acyclovir or Penciclovir." Antimicrobial Agents and Chemotherapy 47, no. 5 (May 2003): 1707–13. http://dx.doi.org/10.1128/aac.47.5.1707-1713.2003.

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ABSTRACT A total of 21 clones of acyclovir (ACV)-resistant (ACVr) herpes simplex virus type 1 (HSV-1) and 23 clones of penciclovir (PCV)-resistant (PCVr) HSV-1, emerging during serial passages in the presence of ACV or PCV, were isolated under conditions excluding contamination of resistant mutants in the starting virus culture, and their mutations in the thymidine kinase (TK) and DNA polymerase (DNA Pol) genes were analyzed comparatively. Mutations in the TK genes from ACVr mutants consisted of 50% single nucleotide substitutions and 50% frameshift mutations, while the corresponding figures for the PCVr mutants were 4 and 96%, respectively (P < 0.001). Eight of the 21 ACVr clones, but none of the 23 PCVr clones, had mutations in DNA Pol. Only nucleotide substitution(s) could be detected in the DNA Pol gene, as the gene is essential for virus replication. Therefore, the results for the DNA Pol mutants are concordant with those for the TK mutants in that a single nucleotide substitution was commonly observed in the ACVr, but not in the PCVr, mutants. These results clearly point to differential mutation patterns between ACVr and PCVr HSV-1 clones.
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25

MAJUMDER, Parimal, Kenichiro TAKAGI, Hidenari SHIOIRI, Masayuki NOZUE, and Mineo KOJIMA. "Functional Analysis of Two Chromosomal Virulence Genes chvA and acvB of Agrobacterium tumefaciens Using Avirulent Mutants with Transposo 5 Insertion in the Respective Gene." Japanese Journal of Phytopathology 65, no. 3 (1999): 254–63. http://dx.doi.org/10.3186/jjphytopath.65.254.

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26

Duan, Jianmin, Michel Liuzzi, William Paris, Francine Liard, Abigail Browne, Nathalie Dansereau, Bruno Simoneau, Anne-Marie Faucher, and Michael G. Cordingley. "Oral Bioavailability and In Vivo Efficacy of the Helicase-Primase Inhibitor BILS 45 BS against Acyclovir-Resistant Herpes Simplex Virus Type 1." Antimicrobial Agents and Chemotherapy 47, no. 6 (June 2003): 1798–804. http://dx.doi.org/10.1128/aac.47.6.1798-1804.2003.

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ABSTRACT This study investigated the oral bioavailability and efficacy of BILS 45 BS, a selective herpes simplex virus (HSV) helicase-primase inhibitor, against acyclovir (ACV)-resistant (ACVr) infections mediated by the HSV type 1 (HSV-1) dlsptk and PAAr5 mutant strains. In vitro, the compound was more potent than ACV against wild-type clinical and laboratory HSV-1 strains and ACVr HSV isolates, as determined by a standard plaque reduction assay, with a mean 50% effective concentration of about 0.15 μM. The oral bioavailability of BILS 45 BS in hairless mice was 49%, with a peak concentration in plasma of 31.5 μM after administration of a single dose of 25 mg/kg. Following cutaneous infection of nude mice, both the HSV-1 dlsptk and PAAr5 mutant strains induced significant, reproducible, and persistent cutaneous lesions that lasted for more than 2 weeks. Oral treatment with ACV (100 or 125 mg/kg/day, three times a day by gavage) did not affect either mutant-induced infection. In contrast, BILS 45 BS at an oral dose of 100 mg/kg/day almost completely abolished cutaneous lesions mediated by both ACVr HSV-1 mutants. The 50% effective doses of BILS 45 BS were 56.7 and 61 mg/kg/day against dlsptk- and PAAr5-induced infections, respectively. Taken together, our results demonstrate very effective oral therapy of experimental ACVr HSV-1 infections in nude mice and support the potential use of HSV helicase-primase inhibitors for the treatment of nucleoside-resistant HSV disease in humans.
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Gonz�lez, Enid T., Darby G. Brown, Jill K. Swanson, and Caitilyn Allen. "Using the Ralstonia solanacearum Tat Secretome To Identify Bacterial Wilt Virulence Factors." Applied and Environmental Microbiology 73, no. 12 (April 27, 2007): 3779–86. http://dx.doi.org/10.1128/aem.02999-06.

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ABSTRACT To identify secreted virulence factors involved in bacterial wilt disease caused by the phytopathogen Ralstonia solanacearum, we mutated tatC, a key component of the twin-arginine translocation (Tat) secretion system. The R. solanacearum tatC mutation was pleiotropic; its phenotypes included defects in cell division, nitrate utilization, polygalacturonase activity, membrane stability, and growth in plant tissue. Bioinformatic analysis of the R. solanacearum strain GMI1000 genome predicted that this pathogen secretes 70 proteins via the Tat system. The R. solanacearum tatC strain was severely attenuated in its ability to cause disease, killing just over 50% of tomato plants in a naturalistic soil soak assay where the wild-type parent killed 100% of the plants. This result suggested that elements of the Tat secretome may be novel bacterial wilt virulence factors. To identify contributors to R. solanacearum virulence, we cloned and mutated three genes whose products are predicted to be secreted by the Tat system: RSp1521, encoding a predicted AcvB-like protein, and two genes, RSc1651 and RSp1575, that were identified as upregulated in planta by an in vivo expression technology screen. The RSc1651 mutant had wild-type virulence on tomato plants. However, mutants lacking either RSp1521, which appears to be involved in acid tolerance, or RSp1575, which encodes a possible amino acid binding protein, were significantly reduced in virulence on tomato plants. Additional bacterial wilt virulence factors may be found in the Tat secretome.
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LONG, Alexandra J., Ian J. CLIFTON, Peter L. ROACH, Jack E. BALDWIN, Christopher J. SCHOFIELD, and Peter J. RUTLEDGE. "Structural studies on the reaction of isopenicillin N synthase with the substrate analogue delta-(l-alpha-aminoadipoyl)-l-cysteinyl-d-alpha-aminobutyrate." Biochemical Journal 372, no. 3 (June 15, 2003): 687–93. http://dx.doi.org/10.1042/bj20021627.

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Isopenicillin N synthase (IPNS) is a non-haem iron(II) oxidase which catalyses the biosynthesis of isopenicillin N from the tripeptide δ-(l-α-aminoadipoyl)-l-cysteinyl-d-valine (ACV). Herein we report crystallographic studies to investigate the reaction of IPNS with the truncated substrate analogue δ-(l-α-aminoadipoyl)-l-cysteinyl-d-α-aminobutyrate (ACAb). It has been reported previously that this analogue gives rise to three β-lactam products when incubated with IPNS: two methyl penams and a cepham. Crystal structures of the IPNS–Fe(II)–ACAb and IPNS–Fe(II)–ACAb–NO complexes have now been solved and are reported herein. These structures and modelling studies based on them shed light on the diminished product selectivity shown by IPNS in its reaction with ACAb and further rationalize the presence of certain key residues at the IPNS active site.
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29

Heidenreich, Daniela, Sebastian Kreil, Nadine Mueller, Mohamad Jawhar, Florian Nolte, Wolf-Karsten Hofmann, and Stefan A. Klein. "Topical Treatment of Acyclovir-Resistant Herpes Simplex Virus Stomatitis after Allogeneic Hematopoietic Cell Transplantation." Oncology Research and Treatment 43, no. 12 (2020): 672–78. http://dx.doi.org/10.1159/000510988.

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<b><i>Introduction:</i></b> We report on patients who developed severe acyclovir-resistant (ACVr) herpes simplex virus 1 (HSV-1) stomatitis after allogeneic hematopoietic cell transplantation (HCT). <b><i>Patients:</i></b> HCT patients suffering from HSV-1 stomatitis without response after 1 week of high-dose acyclovir (ACV) were tested for ACV resistance. Patients with proven ACV resistance were treated either topically with cidofovir solution and gel or with topical foscavir cream or with intravenous foscavir. <b><i>Results:</i></b> Among 214 consecutive HCT patients, 6 developed severe ACVr HSV-1 stomatitis (WHO grade III <i>n</i> = 1, WHO grade IV <i>n</i> = 5). All 6 patients suffered from relapse of acute myeloid leukemia (AML) after HCT. ACVr stomatitis was treated topically with first-line (<i>n</i> = 4) or second-line (<i>n</i> = 2) cidofovir. Topical foscavir cream was applied as first-line (<i>n</i> = 1) or second-line (<i>n</i> = 1) therapy. Intravenous foscavir was used in 3 patients (first-line therapy, <i>n</i> = 1; second-line therapy, <i>n</i> = 2). Complete remission was reached by topical cidofovir (<i>n</i> = 3), topical foscavir (<i>n</i> = 1), and intravenous foscavir (<i>n</i> = 1), respectively. Five of the 6 patients died due to progression of leukemia. Only 1 patient survived. <b><i>Conclusions:</i></b> ACVr HSV-1 stomatitis is a severe complication in AML patients relapsing after HCT. It reflects the seriously impaired general condition of these patients. This analysis shows that topical treatment with cidofovir or foscavir might be a sufficient first-line therapy approach in ACVr HSV-1 stomatitis. It might serve as a less toxic alternative to intravenous foscavir.
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Knuutila, Aapo, Alex-Mikael Barkoff, Jussi Mertsola, Radim Osicka, Peter Sebo, and Qiushui He. "Simultaneous Determination of Antibodies to Pertussis Toxin and Adenylate Cyclase Toxin Improves Serological Diagnosis of Pertussis." Diagnostics 11, no. 2 (January 27, 2021): 180. http://dx.doi.org/10.3390/diagnostics11020180.

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Serological diagnosis of pertussis is mainly based on anti-pertussis toxin (PT) IgG antibodies. Since PT is included in all acellular vaccines (ACV), serological assays do not differentiate antibodies induced by ACVs and infection. Adenylate cyclase toxin (ACT) is not included in the ACVs, which makes it a promising candidate for pertussis serology with the specific aim of separating infection- and ACV-induced antibodies. A multiplex lateral flow test with PT and ACT antigens was developed to measure serum antibodies from pertussis-seropositive patients (n = 46), healthy controls (n = 102), and subjects who received a booster dose of ACV containing PT, filamentous hemagglutinin, and pertactin (n = 67) with paired sera collected before and one month after the vaccination. If the diagnosis was solely based on anti-PT antibodies, 98.5–44.8% specificity (before and after vaccination, respectively) and 78.2% sensitivity were achieved, whereas if ACT was used in combination with PT, the sensitivity of the assay increased to 91.3% without compromising specificity. No increase in the level of anti-ACT antibodies was found after vaccination. This exploratory study indicates that the use of ACT for serology would be beneficial in combination with a lower quantitative cutoff for anti-PT antibodies, and particularly in children and adolescents who frequently receive booster vaccinations.
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31

Bhutta, Maimoona, Oren Shechter, Elisa Gallo, Stephen Martin, Esther Jones, Gustavo Doncel, and Ronen Borenstein. "Ginkgolic Acid Inhibits Herpes Simplex Virus Type 1 Skin Infection and Prevents Zosteriform Spread in Mice." Viruses 13, no. 1 (January 9, 2021): 86. http://dx.doi.org/10.3390/v13010086.

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Herpes simplex virus type 1 (HSV-1) causes a lifelong latent infection with an estimated global prevalence of 66%. Primary and recurrent HSV infections are characterized by a tingling sensation, followed by an eruption of vesicles, which can cause painful erosions. Commonly used antiviral drugs against HSV infection are nucleoside analogues including acyclovir (ACV), famciclovir, and valacyclovir. Although these nucleoside analogues reduce morbidity and mortality in immunocompetent individuals, ACV-resistant HSV strains (ACVR-HSV) have been isolated from immunocompromised patients. Thus, ACVR-HSV infection poses a critical emerging public health concern. Recently, we reported that ginkgolic acid (GA) inhibits HSV-1 by disrupting viral structure, blocking fusion, and inhibiting viral protein synthesis. Additionally, we showed GA affords a broad spectrum of fusion inhibition of all three classes of fusion proteins, including those of HIV, Ebola, influenza A and Epstein Barr viruses. Here we report GA’s antiviral activity against HSV-1 skin infection in BALB/cJ mice. GA-treated mice demonstrated a significantly reduced mortality rate and decreased infection scores compared to controls treated with dimethylsulfoxide (DMSO)-vehicle. Furthermore, GA efficiently inhibited ACVR-HSV-1 strain 17+ in vitro and in vivo. Since GA’s mechanism of action includes virucidal activity and fusion inhibition, it is expected to work alone or synergistically with other anti-viral drugs, and we anticipate it to be effective against additional cutaneous and potentially systemic viral infections.
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Bhutta, Maimoona, Oren Shechter, Elisa Gallo, Stephen Martin, Esther Jones, Gustavo Doncel, and Ronen Borenstein. "Ginkgolic Acid Inhibits Herpes Simplex Virus Type 1 Skin Infection and Prevents Zosteriform Spread in Mice." Viruses 13, no. 1 (January 9, 2021): 86. http://dx.doi.org/10.3390/v13010086.

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Herpes simplex virus type 1 (HSV-1) causes a lifelong latent infection with an estimated global prevalence of 66%. Primary and recurrent HSV infections are characterized by a tingling sensation, followed by an eruption of vesicles, which can cause painful erosions. Commonly used antiviral drugs against HSV infection are nucleoside analogues including acyclovir (ACV), famciclovir, and valacyclovir. Although these nucleoside analogues reduce morbidity and mortality in immunocompetent individuals, ACV-resistant HSV strains (ACVR-HSV) have been isolated from immunocompromised patients. Thus, ACVR-HSV infection poses a critical emerging public health concern. Recently, we reported that ginkgolic acid (GA) inhibits HSV-1 by disrupting viral structure, blocking fusion, and inhibiting viral protein synthesis. Additionally, we showed GA affords a broad spectrum of fusion inhibition of all three classes of fusion proteins, including those of HIV, Ebola, influenza A and Epstein Barr viruses. Here we report GA’s antiviral activity against HSV-1 skin infection in BALB/cJ mice. GA-treated mice demonstrated a significantly reduced mortality rate and decreased infection scores compared to controls treated with dimethylsulfoxide (DMSO)-vehicle. Furthermore, GA efficiently inhibited ACVR-HSV-1 strain 17+ in vitro and in vivo. Since GA’s mechanism of action includes virucidal activity and fusion inhibition, it is expected to work alone or synergistically with other anti-viral drugs, and we anticipate it to be effective against additional cutaneous and potentially systemic viral infections.
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33

Reeve, Wayne G., Lambert Bräu, Joanne Castelli, Giovanni Garau, Christian Sohlenkamp, Otto Geiger, Michael J. Dilworth, Andrew R. Glenn, John G. Howieson, and Ravi P. Tiwari. "The Sinorhizobium medicae WSM419 lpiA gene is transcriptionally activated by FsrR and required to enhance survival in lethal acid conditions." Microbiology 152, no. 10 (October 1, 2006): 3049–59. http://dx.doi.org/10.1099/mic.0.28764-0.

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Sinorhizobium medicae WR101 was identified as a mutant of WSM419 that contained a minitransposon-induced transcriptional gusA fusion activated at least 20-fold at pH 5.7. The expression of this fusion in moderately acid conditions was dependent on the calcium concentration; increasing the calcium concentration to enhance cell growth and survival in acid conditions decreased the expression of the fusion. A gene region containing the gusA fusion was sequenced, revealing five S. medicae genes: tcsA, tcrA, fsrR, lpiA and acvB. The gusA reporter in WR101 was fused to lpiA, which encodes a putative transmembrane protein also found in other Alphaproteobacteria such as Sinorhizobium meliloti, Rhizobium tropici and Agrobacterium tumefaciens. As LpiA has partial sequence similarity to the lysyl-phosphatidylglycerol (LPG) synthetase FmtC/MprF from Staphylococcus aureus, membrane lipid compositions of S. medicae strains were analysed. Cells cultured under neutral or acidic growth conditions did not induce any detectable LPG and therefore this lipid cannot be a major constituent of S. medicae membranes. Expression studies in S. medicae localized the acid-activated lpiA promoter within a 372 bp region upstream of the start codon. The acid-activated transcription of lpiA required the fused sensor–regulator product of the fsrR gene, because expression of lpiA was severely reduced in an S. medicae fsrR mutant. S. meliloti strain 1021 does not contain fsrR and acid-activated expression of the lpiA-gusA fusion did not occur in this species. Although acid-activated lpiA transcription was not required for cell growth, its expression was crucial in enhancing the viability of cells subsequently exposed to lethal acid (pH 4.5) conditions.
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Letsiou, Sophia, Artemis Bakea, Géraldine Le Goff, Philippe Lopes, Konstantinos Gardikis, Michal Weis, Yehuda Benayahu, and Jamal Ouazzani. "Marine Fungus Aspergillus chevalieri TM2-S6 Extract Protects Skin Fibroblasts from Oxidative Stress." Marine Drugs 18, no. 9 (September 8, 2020): 460. http://dx.doi.org/10.3390/md18090460.

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The strain Aspergillus chevalieri TM2-S6 was isolated from the sponge Axinella and identified according to internal transcribed spacer (ITS) molecular sequence homology with Aspergillus species from the section Restricti. The strain was cultivated 9 days on potato dextrose broth (PDB), and the medium evaluated as antioxidant on primary normal human dermal fibroblasts (NHDF). The cultivation broth was submitted to sterile filtration, lyophilized and used without any further processing to give the Aspergillus chevalieri TM2-S6 cultivation broth ingredient named ACBB. ACCB contains two main compounds: tetrahydroauroglaucin and flavoglaucin. Under oxidative stress, ACCB showed a significant promotion of cell viability. To elucidate the mechanism of action, the impact on a panel of hundreds of genes involved in fibroblast physiology was evaluated. Thus, ACCB stimulates cell proliferation (VEGFA, TGFB3), antioxidant response (GPX1, SOD1, NRF2), and extracellular matrix organization (COL1A1, COL3A1, CD44, MMP14). ACCD also reduced aging (SIRT1, SIRT2, FOXO3). These findings indicate that Aspergillus chevalieri TM2-S6 cultivation broth exhibits significant in vitro skin protection of human fibroblasts under oxidative stress, making it a potential cosmetic ingredient.
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Panteva, M., T. Varadinova, and I. Turel. "Effect of Copper Acyclovir Complexes on Herpes Simplex Virus Type 1 and Type 2 (HSV-1, HSV-2) Infection in Cultured Cells." Metal-Based Drugs 5, no. 1 (January 1, 1998): 19–23. http://dx.doi.org/10.1155/mbd.1998.19.

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We have found that when copper, zinc or cobalt is bound to a suitable ligand, the appropriate complex exhibited a significant anti-HSV effect (Varadinova et al., 1993; 1996). Recently published data by Sagripanti et al. (1997) also show that the inhibition of HSV by copper was enhanced by reducing agents and that mechanism of the inactivation is similar as for copper-mediated DNA damage (Aruoma, et al. 1991; Dizdaroglu, et al., 1991; Toyokuni and Sagripanti, 1994). Therefore it was interesting to study the efect of Cu(ll) coordination compounds with acyclovir (ACV) on the replication of HSV in cultured cells. The experiments on cytotoxicity as well as on the activity of three different Cu-ACV complexes [Cu(ACV)2Cl2(H2O)2] = (A); [Cu(ACV)2(H2O)3](NO3)2.H2O = (B) and [Cu(ACV)2(H2O)2](NO3)2] = (C) towards virus replication, with special attention on the growth of ACV-resistant strain R-100 were performed on MDBK cells. ACV was used as a reference compound. The following results were obtained: 1) Increased cell’s viability in the presence of 20-40(g/ml ACV and decreased one in the presence of Cu-ACV complexes with relative level (A) >> (B) > (C); 2) Cu-ACV complexes are more cytotoxic than the ligand - ACV and the relative level is (C)>(B)>(A); 3) The anti-HSV effect of ACV can be modulated by copper at levels depending on the specificity of the particular virus strain: (i) for the ACV sensitive strain DA (HSV-1) - ACV ((A) > (C) > (B); (ii) for the ACV sensitive strain Bja (HSV-2) (A) > ACV > (C) > (B); (iii) for strain R-100 ( ACVR, TKa) - (A) > ACV > (C) > (B). This findings are consistent with previously published data and undoubtedly show that Cu-ACV complexes could be useful in the treatment of HSV infections, especially when the causative agent is a resistant to ACV mutant.
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Martinez Betancur, Octavio, Patricia Quintero Cusguen, and Liliana Mayor Agredo. "Estimación de años de vida ajustados por discapacidad según subtipo de ataque cerebrovascular isquémico agudo." Revista de Salud Pública 18, no. 2 (June 13, 2016): 226–37. http://dx.doi.org/10.15446/rsap.v18n2.31692.

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<p>Objetivo. Probar la hipótesis que los años de vida ajustados por discapacidad (AVAD) estimados al egreso hospitalario para cada paciente con ataque cerebrovascular (ACV) isquémico agudo, sin terapia de reperfusión, no difieren entre los subtipos etiológicos. Material y Métodos. En el Hospital Universitario de la Samaritana de Bogotá, se seleccionaron para ingreso y seguimiento hasta el egreso, las historias de pacientes con diagnóstico de primer evento de ACV isquémico. El subtipo de ACV isquémico agudo se clasificó mediante los criterios establecidos por el Trial of Org 10172 in Acute Stroke Treatment (TOAST). Se estimaron los AVAD individuales de cada paciente con ACV isquémico agudo al egreso. La prueba de Kruskal Wallis se empleó para establecer diferencias de AVAD entre los cinco subtipos de ACV isquémico agudo. Resultados. De 39 pacientes con ACV isquémico agudo, se clasificaron 17 (43,6 %) de etiología aterosclerótica, 10 (25,6 %) con ACVs lacunares, 6 (15,4 %) cardioembólicos y 6 (15,4 %) pacientes sin etiología clara. El total de AVAD aportados por los pacientes con ACV isquémico agudo, fue 316,9 años, sin diferencias estadísticamente significativas entre los subtipos de isquemia. Al egreso hospitalario, un paciente sobreviviente de un ACV isquémico agudo pierde en promedio de 8,12 años de vida óptima libre de discapacidad. Conclusión. Los resultados no conclusivos se atribuyen a la concurrencia de procesos disímiles del cuidado clínico y a las distribuciones de factores de riesgo, comorbilidades y complicaciones de los pacientes.</p>
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37

Takagi, Yuki, Takashi Kojima, Tomoya Nishida, Tomoaki Nakamura, and Kazuo Ichikawa. "Prediction of anterior chamber volume after implantation of posterior chamber phakic intraocular lens." PLOS ONE 15, no. 11 (November 16, 2020): e0242434. http://dx.doi.org/10.1371/journal.pone.0242434.

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Purpose To predict the anterior chamber volume (ACV) after implantable collamer lens (ICL) implantation based on ICL size and parameters of anterior segment optical coherence tomography (AS-OCT). Design Retrospective study. Methods This study included 222 eyes of 222 patients who underwent ICL implantation at Nagoya Eye Clinic. The patients were divided into two groups: prediction group, for creating the prediction equation (148 eyes, mean age: 32.11 ± 8.04 years), and verification group, for verifying the equation (74 eyes, mean age: 33.03 ± 6.74 years). The angle opening distance (AOD), anterior chamber width (ACW), ACV, anterior chamber depth, lens vault, angle-to-angle distance, angle recess area, and trabecular iris space area were calculated using AS-OCT. A stepwise multiple regression analysis was performed. After the creation of the prediction equation, its accuracy was verified in the verification group. Results The ACV, AOD750, ACW, and ICL size were selected as explanatory variables to predict postoperative ACV. Mean predicted (114.2 ± 21.83 mm3) and actual postoperative ACVs (116.1 ± 25.41 mm3) were not significantly different (P = 0.269); absolute error was 10.59 ± 9.13 mm3. In addition, there was high correlation between actual and predictive ACV (adjusted R2 = 0.6996, p < 0.0001). Bland-Altman plot revealed that there was no addition or proportional error between predicted and actual postoperative ACV. Conclusion Postoperative ACV was accurately predicted using AS-OCT parameters and ICL size. This prediction equation may be useful for making decisions regarding ICL size.
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Timofeyev, Valeriy, Cliff A. Porter, Dipika Tuteja, Hong Qiu, Ning Li, Tong Tang, Anil Singapuri, et al. "Disruption of adenylyl cyclase type V does not rescue the phenotype of cardiac-specific overexpression of Gαq protein-induced cardiomyopathy." American Journal of Physiology-Heart and Circulatory Physiology 299, no. 5 (November 2010): H1459—H1467. http://dx.doi.org/10.1152/ajpheart.01208.2009.

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Adenylyl cyclase (AC) is the principal effector molecule in the β-adrenergic receptor pathway. ACV and ACVI are the two predominant isoforms in mammalian cardiac myocytes. The disparate roles among AC isoforms in cardiac hypertrophy and progression to heart failure have been under intense investigation. Specifically, the salutary effects resulting from the disruption of ACV have been established in multiple models of cardiomyopathy. It has been proposed that a continual activation of ACV through elevated levels of protein kinase C could play an integral role in mediating a hypertrophic response leading to progressive heart failure. Elevated protein kinase C is a common finding in heart failure and was demonstrated in murine cardiomyopathy from cardiac-specific overexpression of Gαq protein. Here we assessed whether the disruption of ACV expression can improve cardiac function, limit electrophysiological remodeling, or improve survival in the Gαq mouse model of heart failure. We directly tested the effects of gene-targeted disruption of ACV in transgenic mice with cardiac-specific overexpression of Gαq protein using multiple techniques to assess the survival, cardiac function, as well as structural and electrical remodeling. Surprisingly, in contrast to other models of cardiomyopathy, ACV disruption did not improve survival or cardiac function, limit cardiac chamber dilation, halt hypertrophy, or prevent electrical remodeling in Gαq transgenic mice. In conclusion, unlike other established models of cardiomyopathy, disrupting ACV expression in the Gαq mouse model is insufficient to overcome several parallel pathophysiological processes leading to progressive heart failure.
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Sarisky, Robert T., Matthew R. Quail, Philip E. Clark, Tammy T. Nguyen, Wendy S. Halsey, Robert J. Wittrock, Joan O'Leary Bartus, et al. "Characterization of Herpes Simplex Viruses Selected in Culture for Resistance to Penciclovir or Acyclovir." Journal of Virology 75, no. 4 (February 15, 2001): 1761–69. http://dx.doi.org/10.1128/jvi.75.4.1761-1769.2001.

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ABSTRACT Penciclovir (PCV), an antiherpesvirus agent in the same class as acyclovir (ACV), is phosphorylated in herpes simplex virus (HSV)-infected cells by the viral thymidine kinase (TK). Resistance to ACV has been mapped to mutations within either the TK or the DNA polymerase gene. An identical activation pathway, the similarity in mode of action, and the invariant cross-resistance of TK-negative mutants argue that the mechanisms of resistance to PCV and ACV are likely to be analogous. A total of 48 HSV type 1 (HSV-1) and HSV-2 isolates were selected after passage in the presence of increasing concentrations of PCV or ACV in MRC-5 cells. Phenotypic analysis suggested these isolates were deficient in TK activity. Moreover, sequencing of the TK genes from ACV-selected mutants identified two homopolymeric G-C nucleotide stretches as putative hot spots, thereby confirming previous reports examining Acvr clinical isolates. Surprisingly, mutations identified in PCV-selected mutants were generally not in these regions but distributed throughout the TK gene and at similar frequencies of occurrence within A-T or G-C nucleotides, regardless of virus type. Furthermore, HSV-1 isolates selected in the presence of ACV commonly included frameshift mutations, while PCV-selected HSV-1 mutants contained mostly nonconservative amino acid changes. Data from this panel of laboratory isolates show that Pcvr mutants share cross-resistance and only limited sequence similarity with HSV mutants identified following ACV selection. Subtle differences between PCV and ACV in the interaction with viral TK or polymerase may account for the different spectra of genotypes observed for the two sets of mutants.
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Le, Duong Van, Dat Duy Nguyen, and Toan Van Mai. "Investigation of heave dynamics of an air cushion vehicle segment skirt." Science and Technology Development Journal 20, K5 (August 31, 2017): 23–29. http://dx.doi.org/10.32508/stdj.v20ik5.1154.

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Air Cushion Vehicle (ACV) is a moving vehicle on airbags, which can travel on land and on water to transport people, goods and equipment. An important requirement for ACVs is to: increase reliability and longevity, reduce operating costs, stability and mobility. In this paper, a model for the dynamic behavior of air cushion vehicles segment skirt is presented. In this model, the compressible Bernoulli's equation, Newton's second law of motion are used to predict the dynamic behavior of the air cushion vehicles. Based on the developed model, the heave dynamics parameters of the air cushion vehicles “Hovertrek 6100L” are surveyed.
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41

Thieblemont, Catherine, Bettina Altmann, Olivier Casasnovas, Fabian Frontzek, Franck Morschhauser, Lucie Oberic, Viola Poeschel, et al. "CNS relapse in DLBCL patients below 60 years treated with R-ACVBP, R-CHOEP, or R-CHOP: A joint analysis of LYSA and GLA/DSHNHL." Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021): 7543. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.7543.

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7543 Background: Central nervous system (CNS) relapse occurs in 2-6% of DLBCL patients (pts) increasing to 10% or more in high-risk groups. Intrathecal (IT) or intravenous high-dose methotrexate (HD MTX) have limited if any prophylactic impact on CNS relapse. To address the role of systemic first-line therapy in pts tolerating intensified strategies (R-ACVBP, R-(Mega)CHOEP, R-CHO(E)P), we compared CNS relapses occurring in a large cohort of pts ≤60 years. Methods: We conducted a retrospective analysis including previously untreated pts with DLBCL by central review, age 18-60 years, from multicenter clinical trials conducted by LYSA and GLA/DSHNHL (Table). We assessed the risk of CNS relapse in matched cohorts based on the aaIPI. Results: A total of 2203 pts were included. Median age was 47 years (18-60). 455 pts were treated with R-ACVBP, 444 with R-(Mega)CHOEP, 1304 with R-CHOP. Distribution of CNS IPI was not significantly different comparing R-ACVBP to R-CHO(E)P groups within aaIPI categories (Table). PFS and OS were comparable according to treatment within aaIPI groups, also adjusted for prognostic factors. No CNS events occured during observation time of 3 years in pts with aaIPI 0. In pts with aaIPI 1, no CNS event occured in the R-ACVPB arm, the 3y-cumulative incidence of CNS relapse for pts treated with R-CHO(E)P group was 1.0% (95%CI 0.3-1.7). In pts with aaIPI 2,3 and intermediate/high CNS IPI, four (1.6%) treated with R-ACVBP experienced relapse in the CNS compared to 15 (3.9%) pts treated with R-(Mega)CHO(E)P (3y-cumulative incidence 1.6% (95%CI 0-3.2) vs. 4.0% (95%CI 2.0-6.0). Conclusions: CNS relapse was extremely rare in younger DLBCL pts with aaIPI 0 or 1; prophylactic measures are not warranted. In pts with aaIPI 2,3 (and intermediate/high CNS-IPI), only 4 (1.6%) CNS relapses were seen with the R-ACVBP while 15 (3.9%) relapses did occur after R-(Mega)CHO(E)P. This analysis underlines the important role of the systemic therapy in controling CNS relapse.[Table: see text]
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42

Allison, John L. "Air Cushion Vehicles and Surface Effect Ships for Great Lakes and Great Rivers Transportation." Marine Technology and SNAME News 27, no. 06 (November 1, 1990): 337–55. http://dx.doi.org/10.5957/mt1.1990.27.6.337.

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A brief introduction to air cushion vehicle (ACV) and surface effect ship (SES) technology is presented, with past and present examples, to show that this technology may now be considered mature. Applicability of ACVs and SESs to transportation on the Great Lakes and rivers of Canada and the U.S. is discussed, with some emphasis on year-round service in the regions affected by ice. An indication of present design capabilities is provided with some examples of application to typical sets of requirements. Future developments are outlined in the light of the rapid expansion of air-supported ferry operation in other parts of the world, and military and Coast Guard applications in the U.S. and Canada. Some data on acquisition and operating costs are presented in comparison with those for other hull forms, with information on the type of technical and port support required for ACV and SES operation. Numerous references are provided to enable the reader to pursue the topics discussed in greater detail than is possible in a short paper.
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43

Bhutta, Maimoona, Daniel Sausen, Kirstin Reed, Elisa Gallo, Pamela Hair, Brittany Lassiter, Neel Krishna, Kenji Cunnion, and Ronen Borenstein. "Peptide Inhibitor of Complement C1, RLS-0071, Reduces Zosteriform Spread of Herpes Simplex Virus Type 1 Skin Infection and Promotes Survival in Infected Mice." Viruses 13, no. 8 (July 22, 2021): 1422. http://dx.doi.org/10.3390/v13081422.

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Herpes simplex virus type 1 (HSV-1) is a prevalent human pathogen primarily transmitted through skin-to-skin contact, especially on and around mucosal surfaces where there is contact with contaminated saliva during periods of viral shedding. It is estimated that 90% of adults worldwide have HSV-1 antibodies. Cutaneous HSV-1 infections are characterized by a sensation of tingling or numbness at the initial infection site followed by an eruption of vesicles and then painful ulcers with crusting. These symptoms can take ten days to several weeks to heal, leading to significant morbidity. Histologically, infections cause ballooning degeneration of keratinocytes and formation of multinucleated giant cells, ultimately resulting in a localized immune response. Commonly prescribed treatments against HSV-1 infections are nucleoside analogs, such as acyclovir (ACV). However, the emergence of ACV-resistant HSV (ACVR-HSV) clinical isolates has created an urgent need for the development of compounds to control symptoms of cutaneous infections. RLS-0071, also known as peptide inhibitor of complement C1 (PIC1), is a 15-amino-acid anti-inflammatory peptide that inhibits classical complement pathway activation and modulates neutrophil activation. It has been previously shown to aid in the healing of chronic diabetic wounds by inhibiting the excessive activation of complement component C1 and infiltration of leukocytes. Here, we report that treatment of cutaneous infections of HSV-1 and ACVR-HSV-1 in BALB/cJ mice with RLS-0071 significantly reduced the rate of mortality, decreased zosteriform spread, and enhanced the healing of the infection-associated lesions compared to control-treated animals. Therefore, RLS-0071 may work synergistically with other antiviral drugs to aid in wound healing of HSV-1 cutaneous infection and may potentially aid in rapid wound healing of other pathology not limited to HSV-1.
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44

Tabares-Montoya, Daniel Alberto, Stefany Barahona-Giraldo, Lucy Ramírez-Reyes, and Olga Alicia Nieto-Cárdenas. "ACCIDENTE CEREBROVASCULAR Y FIBRILACIÓN AURICULAR EN UNA INSTITUCIÓN PRESTADORA DE SALUD DEL QUINDÍO." Revista de Investigaciones Universidad del Quindío 33, no. 1 (May 27, 2021): 115–25. http://dx.doi.org/10.33975/riuq.vol33n1.458.

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Introducción: La Fibrilación Auricular (FA) se ha relacionado frecuentemente con el Accidente Cerebrovascular (ACV). Objetivo: Describir la prevalencia de FA y sus comorbilidades en pacientes de un programa de Riesgo Cardiovascular de una Institución Prestadora de Servicios de Salud (IPS) del Quindío. Material y método: Estudio descriptivo de corte transversal. Se accedió a las historias clínicas de 193 pacientes con diagnóstico de FA, con consentimiento institucional. Se obtuvo una muestra de 53 sujetos de estudio, calculada para población finita, ajustada por prevalencia, aleatorizada, con reemplazo sistemático, sino se tenía la información requerida. Se calculó prevalencia de FA y de Accidente Cerebrovascular isquémico (ACVi), el uso de medicamentos para control de frecuencia, control del ritmo y anticoagulantes, la escala CHA2-DS2-VASC y la clasificación del riesgo. Resultados: Se encontró prevalencia de FA del 5,01% y de ACVi del 7,55%. Índice de Masa Corporal (IMC) promedio de 27,44 (± 6,20). El carvedilol fue el medicamento más usado (50,94%) para control de la frecuencia, la amiodarona el medicamento más usado (11,32%) para control del ritmo y el rivaroxabán (50,94%) como anticoagulante. Se identificó hipertensión en 100% de los pacientes, diabetes en 37,74 % y enfermedad vascular en 32,98 %, las cuales son variables de la escala CHA2-DS2-VASC con alta prevalencia esta población. Conclusiones: La prevalencia de FA fue de 5,01% y la prevalencia de ACVi del 7,55%. El puntaje promedio de la escala CHA2-DS2-VASC fue 4,26 y el 88,68% de la población se encontró en riesgo alto de Accidente cerebrovascular.
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45

Odeh, Fadi, and Nijad Al-Najdawi. "ACNB." International Journal of Information Technology and Web Engineering 8, no. 1 (January 2013): 23–35. http://dx.doi.org/10.4018/jitwe.2013010102.

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Integrating association rule discovery and classification in data mining brings a new approach known as associative classification. Associative classification is a promising approach that often constructs more accurate classification models (classifiers) than the traditional classification approaches such as decision trees and rule induction. In this research, the authors investigate the use of associative classification on the high dimensional data in text categorization. This research focuses on prediction, a very important step in classification, and introduces a new prediction method called Associative Classification Mining based on Naïve Bayesian method. The running time is decreased by removing the ranking procedure that is usually the first step in ranking the derived Classification Association Rules. The prediction method is enhanced using the Naïve Bayesian Algorithm. The results of the experiments demonstrate high classification accuracy.
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46

Markey, Kevin, Catpagavalli Asokanathan, and Ian Feavers. "Assays for Determining Pertussis Toxin Activity in Acellular Pertussis Vaccines." Toxins 11, no. 7 (July 17, 2019): 417. http://dx.doi.org/10.3390/toxins11070417.

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Whooping cough is caused by the bacterium Bordetella pertussis. There are currently two types of vaccines that can prevent the disease; whole cell vaccines (WCV) and acellular vaccines (ACV). The main virulence factor produced by the organism is pertussis toxin (PTx). This toxin is responsible for many physiological effects on the host, but it is also immunogenic and in its detoxified form is the main component of all ACVs. In producing toxoid for vaccines, it is vital to achieve a balance between sufficiently detoxifying PTx to render it safe while maintaining enough molecular structure that it retains its protective immunogenicity. To ensure that the first part of this balancing act has been successfully achieved, assays are required to accurately measure residual PTx activity in ACV products accurately. Quality control assays are also required to ensure that the detoxification procedures are robust and stable. This manuscript reviews the methods that have been used to achieve this aim, or may have the potential to replace them, and highlights their continuing requirement as vaccines that induce a longer lasting immunity are developed to prevent the re-occurrence of outbreaks that have been observed recently.
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47

Tegenbos, Guy. "Sociale verkiezingen 1987 : Kaderleden verzwakken traditionele vakbonden." Res Publica 30, no. 2-3 (September 30, 1988): 299–310. http://dx.doi.org/10.21825/rp.v30i2-3.18901.

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In 1987 the centre-right coalition was able to break through partially the triopoly of the three trade unions - the christian ACV, the socialist ABVV en the liberal ACLVB - by admitting to the four-yearly social elections separate lists of candidates for the members of the executive staffs.As a result of this, the position of the three unions weakened. The decline was most strongly felt by the ABVV; the socialist union lost 2.6 %. The minor loss of 0.7 % enabled the christian ACV to regain its position as the strongest Belgian union, a position which was taken for the first time in 1979 and was lost again in the elections of 1983.After thë recent social elections, neither the unions (43.7 % ), nor the « independent » National Confederation of the Executive Staff Members (34 .1 %), nor the individual lists of the members of the executive staffs (222 %) can cÏaim io be « the representator » of the members of the executive staffs.Through the analysis of the 1987 results, it is found once more that social elections are little affected by political events. The results of the social elections are in no way correlated to the results of the politicalelections.
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48

Thieblemont, C., D. Antal, L. Lacotte-Thierry, V. Delwail, F. Bouafia, S. Tartas, A. S. Michallet, et al. "Rituximab/Chemotherapy Induction Treatment Followed by High-Dose Therapy and Autologous Transplantation in Patients with Mantle Cell Lymphoma." Blood 104, no. 11 (November 16, 2004): 1389. http://dx.doi.org/10.1182/blood.v104.11.1389.1389.

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Abstract Between September 1998 and September 2003, 25 patients with Mantle Cell Lymphoma (MCL) were treated in our centres with a treatment combining rituximab + chemotherapy at induction with subsequent consolidation high-dose chemo/radiotherapy (HDT) and autologous PBSC-transplantation. Twenty-two (80%) patients received this treatment in first line therapy. Median age of patients was 53 (range: 41–65). All patients had a disseminated disease with a bone marrow (BM) involvement in 23 (92%) patients. Elevated LDH was present in 11 patients. All patients except one had a good performance status. IPI score was low in 5 patients, low-intermediate in 10 patients, high-intermediate in 7 patients and high in 3 patients. Chemotherapy induction regimens were: R-CHOP (n=7 pts), R-ACVB (n=4 pts), R-ESHAP (n=1 pts), R-DHAP (n=1pts), or sequential CHOP+DHAP/ESHAP+Rituximab (n=12pts) regimens. Rituximab was giving simultaneously with the chemotherapy in 13 patients or just before harvest in 12 patients. Number of rituximab injections was four in all patients except one that received 5 injections. PBSC harvest was done after cyclophosphamide or cyclophosphmide + etoposide followed by G-CSF and was successful in all patients with a median number of CD34+ cells at 6.44 106/kg. HDT included TBI in 21 patients. After induction therapy, all patients were in response: 16 (64%) reached a CR and 9 (36%) a PR because of persistence of a weak (&lt;5%) BM involvement. Evaluation three months after transplant showed a CR in 17 (68%) patients and a PR in 7 (24%) patients because of weak BM involvement. At 3 years, 80% (20/25) of the patients are still alive (Figure). With a median follow-up at 4 years, median time to progression was 3.3 years. Four patients died from progressive disease. Transplantation toxicities were similar to those observed with regular induction treatment without rituximab with a median time of achievement of a PN count &gt; 0.5GI/L at 10 days. One patient died before neutrophil recovery because of undocumented pulmonary infection. No patient presented late neutropenia. In conclusion, combined induction chemotherapy with rituximab followed by HDT dramatically improved the overall survival and the progression free survival in MCL patients, without adding hematological toxicities and infectious complications. Figure Figure
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49

McElgunn, Peggy. "ACVP Update." Cardiac Cath Lab Director 1, no. 1 (February 2011): 46. http://dx.doi.org/10.1177/2150133510395714.

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50

Krämer-Hoppe, Rike. "ACAB = Beleidigung?" JURA - Juristische Ausbildung 40, no. 6 (May 1, 2018): 621–30. http://dx.doi.org/10.1515/jura-2018-0128.

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