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Relevant bibliographies by topics / Acyl glucuronid

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Academic literature on the topic 'Acyl glucuronid'

Author: Grafiati

Published: 4 June 2021

Last updated: 3 February 2022

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Journal articles on the topic "Acyl glucuronid"

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Yuan, Long, Xiaohui Sophia Xu, and Qin C. Ji. "Challenges and recommendations in developing LC–MS/MS bioanalytical assays of labile glucuronides and parent compounds in the presence of glucuronide metabolites." Bioanalysis 12, no. 9 (2020): 615–24. http://dx.doi.org/10.4155/bio-2020-0055.

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Glucuronides, especially acyl glucuronides, were often found to be unstable in vitro and in vivo. Acyl glucuronide metabolites can convert back to the parent drugs at physiological pH through hydrolysis. Glucuronides can also undergo in-source fragmentation during MS ionization to form the same ions as those of the parent compounds, which could cause interference to the analysis of the parent compounds. All of these may cause significant challenges in developing LC–MS/MS bioanalytical assays of labile glucuronides or parent compounds in the presence of glucuronide metabolites. In this manuscri

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Little, Michael S., Samuel J. Pellock, William G. Walton, Ashutosh Tripathy та Matthew R. Redinbo. "Structural basis for the regulation of β-glucuronidase expression by human gut Enterobacteriaceae". Proceedings of the National Academy of Sciences 115, № 2 (2017): E152—E161. http://dx.doi.org/10.1073/pnas.1716241115.

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The gut microbiota harbor diverse β-glucuronidase (GUS) enzymes that liberate glucuronic acid (GlcA) sugars from small-molecule conjugates and complex carbohydrates. However, only the Enterobacteriaceae family of human gut-associated Proteobacteria maintain a GUS operon under the transcriptional control of a glucuronide repressor, GusR. Despite its potential importance in Escherichia, Salmonella, Klebsiella, Shigella, and Yersinia opportunistic pathogens, the structure of GusR has not been examined. Here, we explore the molecular basis for GusR-mediated regulation of GUS expression in response

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Vree, Tom B., Yechiel A. Hekster, and Patricia G. Anderson. "Contribution of the Human Kidney to the Metabolic Clearance of Drugs." Annals of Pharmacotherapy 26, no. 11 (1992): 1421–28. http://dx.doi.org/10.1177/106002809202601116.

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OBJECTIVE: To demonstrate that the human kidney is capable not only of filtering and secreting drugs and their metabolites, but also of carrying out conjugation reactions such as acyl glucuronidation, N-glucuronidation, and glycination. DATA SOURCES: Plasma concentrations and renal excretion rates of drugs are measured and renal clearance is calculated in a series of selected pharmacokinetic studies in healthy human volunteers (some studies were conducted in the authors' laboratory and others were reported in the literature). BACKGROUND THEORY: It is generally agreed that the liver plays the d

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Bradshaw, Peter R., Toby J. Athersuch, Andrew V. Stachulski, and Ian D. Wilson. "Acyl glucuronide reactivity in perspective." Drug Discovery Today 25, no. 9 (2020): 1639–50. http://dx.doi.org/10.1016/j.drudis.2020.07.009.

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Skopp, Gisela, та Lucia Pötsch. "Stability of 11-Nor-Δ9-carboxy-tetrahydrocannabinol Glucuronide in Plasma and Urine Assessed by Liquid Chromatography-Tandem Mass Spectrometry". Clinical Chemistry 48, № 2 (2002): 301–6. http://dx.doi.org/10.1093/clinchem/48.2.301.

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Abstract Background: Unconjugated 11-nor-Δ9-carboxy-tetrahydrocannabinol (THCCOOH) in blood and urine has been proposed as a valuable marker, but the glucuronide (THCCOOglu) is present in considerably higher concentrations than the parent drug. Acyl glucuronides have been shown to be potentially reactive conjugates, which may affect the in vitro metabolite pattern. Methods: Extraction procedures and a liquid chromatography-tandem mass spectrometry assay were developed and validated to investigate the stability of THCCOOglu in urine and plasma. Plasma and urine samples with added THCCOOglu were

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Bradshaw, Peter R., Selena E. Richards, Ian D. Wilson, Andrew V. Stachulski, John C. Lindon, and Toby J. Athersuch. "Kinetic modelling of acyl glucuronide and glucoside reactivity and development of structure–property relationships." Organic & Biomolecular Chemistry 18, no. 7 (2020): 1389–401. http://dx.doi.org/10.1039/c9ob02008j.

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Detailed kinetic and transition structure modelling to rationalise the differences in reactivity observed between the acyl glucuronide and glucoside metabolites of a series of phenylacetic acid analogues.

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A. Boelsterli, Urs, and Veronica Ramirez-Alcantara. "NSAID Acyl Glucuronides and Enteropathy." Current Drug Metabolism 12, no. 3 (2011): 245–52. http://dx.doi.org/10.2174/138920011795101877.

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De Mesmaeker, Alain, Pascale Hoffmann та Beat Ernst. "A new protected form of glucuronic acid for the synthesis of labile 1-O-acyl-β-D-glucuronides". Tetrahedron Letters 30, № 29 (1989): 3773–76. http://dx.doi.org/10.1016/s0040-4039(01)80651-1.

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Sallustio, B., L. Sabordo, A. Evans, and R. Nation. "Hepatic Disposition of Electrophilic Acyl Glucuronide Conjugates." Current Drug Metabolism 1, no. 2 (2000): 163–80. http://dx.doi.org/10.2174/1389200003339153.

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Bailey, Mark J., and Ronald G. Dickinson. "Acyl glucuronide reactivity in perspective: biological consequences." Chemico-Biological Interactions 145, no. 2 (2003): 117–37. http://dx.doi.org/10.1016/s0009-2797(03)00020-6.

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Dissertations / Theses on the topic "Acyl glucuronid"

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Bailey, Mark J. "Acyl glucuronide reactivity : some biological consequences /." [St. Lucia, Qld.], 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16205.pdf.

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Kenny, Jane Ruth. "An investigation of acyl glucuronides." Thesis, University of Liverpool, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269597.

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Skordi, Eleni. "NMR investigations into the reactivity of drug acyl glucuronides." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419921.

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Vanderhoeven, Stephen John. "Synthesis and NMR studies on the reactivity of O-acyl glucuronides." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400661.

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Perrie, Jennifer Anne. "New methods for the synthesis of O-alkyl and acyl glucuronides." Thesis, University of Liverpool, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.428259.

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Iddon, Lisa. "The synthesis of biological important phase II Metabolites; 1-B-O-Acyl Glucuronides." Thesis, University of Liverpool, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.511038.

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Hammond, Thomas. "In vitro and in vivo investigations into the interactions between the acyl glucuronide metabolite of diclofenac and serum albumin." Thesis, University of Liverpool, 2012. http://livrepository.liverpool.ac.uk/10013/.

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Adverse drug reactions represent a major challenge to clinicians, healthcare systems, pharmaceutical companies and academia. With carboxylic acid drugs accounting for the most common class of drugs withdrawn from the market, the carboxylate pharmacophore has received much attention as a potential toxicophore. Direct glucuronidation of the carboxylate group, producing chemically unstable and protein reactive acyl glucuronide (AG) metabolites has received much attention as a bioactivation pathway responsible for generation of these off-target hypersensitivity and hepatotoxicity. It is the chemic

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Lassila, T. (Toni). "In vitro methods in the study of reactive drug metabolites with liquid chromatography / mass spectrometry." Doctoral thesis, Oulun yliopisto, 2016. http://urn.fi/urn:isbn:9789526212197.

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Abstract Reactive metabolites are believed to be responsible for rare but serious idiosyncratic adverse drug reactions (IADRs) that have led to the withdrawal of numerous drugs from the market. This has resulted in major harm to patients, economic losses for the pharmaceutical companies and represents a serious problem in drug development. Reactive metabolites can be studied by trapping them with suitable nucleophiles, most commonly with glutathione. The glutathione conjugates formed in these reactions can be analyzed with liquid chromatography mass spectrometry (LC/MS) techniques. In this stu

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Bolze, Sébastien. "Mise au point d'un modèle de prédiction de la réactivité de métabolites : les acyl glucuronides et d'analyse du risque de leur réactivité." Lyon 1, 2002. http://www.theses.fr/2002LYO10038.

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Les acyl glucuronides ont la propriété d'être instables à pH physiologique et peuvent redonner par hydrolyse leur aglycone ou conduire à la formation d'isomères de position par le phénomène d'acyl migration. Les isomères acyl glucuronides sont capables de se fixer de façon covalente aux protéines entraînant des phénomènes toxiques dont les mécanismes sont toujours inconnus. Certaines molécules donnant lieu à ce type de métabolites ont été retirés du marché suite à des effets secondaires de type immuno-allergiques (zomépirac, tolmétine, bénoxaprofène, ibufénac. . . ). Une identification précoce

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Schwabe, Hendrik Eberhard. "Die inhibitorische Wirkung des Acylglucuronidmetaboliten der Mycophenolsäure auf die Inosinmonophosphatdehydrogenase Typ II." Doctoral thesis, 2011. http://hdl.handle.net/11858/00-1735-0000-0006-B2AC-5.

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Book chapters on the topic "Acyl glucuronid"

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Spahn-Langguth, Hildegard, Monika Dahms, and Andreas Hermening. "Acyl Glucuronides." In Advances in Experimental Medicine and Biology. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4757-9480-9_39.

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Fenselau, C. "Acyl Glucuronides as Chemically Reactive Intermediates." In Handbook of Experimental Pharmacology. Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-78429-3_13.

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Zhou, Jin, Feng Frank Li, and Jeffrey X. Duggan. "LC-MS Bioanalysis of ACYL Glucuronides." In Handbook of LC-MS Bioanalysis. John Wiley & Sons Inc., 2013. http://dx.doi.org/10.1002/9781118671276.ch35.

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Xu, Rongfang Fran, Wing W. Lam, Jie Chen, Michael McMillian, Jose Silva, and Heng-Keang Lim. "In Vitro Assessment of the Reactivity of Acyl Glucuronides." In Methods in Pharmacology and Toxicology. Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-742-6_30.

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van Breemen, Richard B., Catherine C. Fenselau, and Deanne M. Dulik. "Activated Phase II Metabolites: Comparison of Alkylation by 1-0-Acyl Glucuronides and Acyl Sulfates." In Biological Reactive Intermediates III. Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-5134-4_41.

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Bolze, Sébastien. "In Vitro Screening Assay of the Reactivity of Acyl Glucuronides." In Optimization in Drug Discovery. Humana Press, 2004. http://dx.doi.org/10.1385/1-59259-800-5:385.

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Ruelius, H. W., S. K. Kirkman, E. M. Young, and F. W. Janssen. "Reactions of Oxaprozin-1-0-Acyl Glucuronide in Solutions of Human Plasma and Albumin." In Biological Reactive Intermediates III. Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-5134-4_42.

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Meffin, P. J. "The Effect of Renal Dysfunction on the Disposition of Non-Steroidal Anti-Inflammatory Drugs Forming Acyl-Glucuronides." In Non-steroidal Anti-Inflammatory Drugs Basis for Variability in Response. Birkhäuser Basel, 1985. http://dx.doi.org/10.1007/978-3-0348-7720-6_10.

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Wainhaus, Sam. "Acyl Glucuronides." In Using Mass Spectrometry for Drug Metabolism Studies. CRC Press, 2004. http://dx.doi.org/10.1201/9780203500040.ch6.

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Horng, Howard, Hilde Spahn-Langguth, and Leslie Z. Benet. "Mechanistic Role of Acyl Glucuronides." In Drug-Induced Liver Disease. Elsevier, 2013. http://dx.doi.org/10.1016/b978-0-12-387817-5.00003-0.

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