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Dissertations / Theses on the topic 'ADAM8'

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Published: 4 June 2021
Last updated: 7 February 2022

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1

Nishimura, Daigo. "Roles of ADAM8 in elimination of injured muscle fibers prior to skeletal muscle regeneration." Kyoto University, 2015. http://hdl.handle.net/2433/199212.

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Sasko, Eric [Verfasser], and Udo [Akademischer Betreuer] Bakowsky. "Entwicklung und Charakterisierung echogener Liposomen zur Targetierung von ADAM8 / Eric Sasko ; Betreuer: Udo Bakowsky." Marburg : Philipps-Universität Marburg, 2017. http://d-nb.info/1135385599/34.

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Yu, Xiangdi [Verfasser], and Jörg W. [Akademischer Betreuer] Bartsch. "Purification and Functional Characterization of Recombinant Human ADAM8 protease / Xiangdi Yu. Betreuer: Jörg W. Bartsch." Marburg : Philipps-Universität Marburg, 2015. http://d-nb.info/1071947788/34.

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Liang, Jingjing. "Toxicity and Processing of Cellular Prion Protein in Skeletal Muscles." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1323450797.

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5

Heß, Franz Martin [Verfasser]. "The role of the metalloproteases ADAM8, 9, 10 and 17 in leukocyte migration in vitro / Franz Martin Heß." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2013. http://d-nb.info/1037046021/34.

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6

Schicktanz, Hanka Iris [Verfasser]. "Immunhistochemische Expressionsanalyse von RECK, ADAM8, CD146 und COX-2 auf ihre Eignung als Prognosemarker des Prostatakarzinoms / Hanka Iris Schicktanz." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2010. http://d-nb.info/1024364720/34.

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7

Richens, Joanna. "Expression of ADAM8 on cells of the immune system and potential modulation by the mite allergen Der p 1." Thesis, University of Nottingham, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.438327.

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8

Schumacher, Julian Verfasser], Andreas [Akademischer Betreuer] Ludwig, and Gabriele [Akademischer Betreuer] [Pradel. "Role of the proteases ADAM8, ADAM10 and ADAM17 in bleomycin induced lung inflammation / Julian Schumacher ; Andreas Ludwig, Gabriele Pradel." Aachen : Universitätsbibliothek der RWTH Aachen, 2018. http://d-nb.info/1169915183/34.

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Schumacher, Julian [Verfasser], Andreas Akademischer Betreuer] Ludwig, and Gabriele [Akademischer Betreuer] [Pradel. "Role of the proteases ADAM8, ADAM10 and ADAM17 in bleomycin induced lung inflammation / Julian Schumacher ; Andreas Ludwig, Gabriele Pradel." Aachen : Universitätsbibliothek der RWTH Aachen, 2018. http://d-nb.info/1169915183/34.

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Awan, Tanzeela Verfasser], Andreas [Akademischer Betreuer] Ludwig, Gabriele [Akademischer Betreuer] [Pradel, and Martin [Akademischer Betreuer] Zenke. "Role and regulation of the metalloproteinase ADAM8 in liver inflammation and hepatocellular carcinoma / Tanzeela Awan ; Andreas Ludwig, Gabriele Pradel, Martin Zenke." Aachen : Universitätsbibliothek der RWTH Aachen, 2021. http://d-nb.info/1227992858/34.

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Awan, Tanzeela [Verfasser], Andreas Akademischer Betreuer] Ludwig, Gabriele [Akademischer Betreuer] [Pradel, and Martin [Akademischer Betreuer] Zenke. "Role and regulation of the metalloproteinase ADAM8 in liver inflammation and hepatocellular carcinoma / Tanzeela Awan ; Andreas Ludwig, Gabriele Pradel, Martin Zenke." Aachen : Universitätsbibliothek der RWTH Aachen, 2021. http://d-nb.info/1227992858/34.

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12

Adami, Stefan [Verfasser], Nikolaus A. [Akademischer Betreuer] Adams, and Joe J. [Akademischer Betreuer] Monaghan. "Modeling and Simulation of Multiphase Phenomena with Smoothed Particle Hydrodynamics / Stefan Adami. Gutachter: Joe J. Monaghan ; Nikolaus A. Adams. Betreuer: Nikolaus A. Adams." München : Universitätsbibliothek der TU München, 2014. http://d-nb.info/1051734878/34.

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13

Coronado, Mônika Aparecida. "Estudo por Modelagem e Dinâmica Molecular da Interação da Integrina alfa6beta1 com o Domínio Tipo-disintegrina de ADAM2 E ADAM9 Humanas." Laboratório Nacional de Computação Científica, 2008. http://www.lncc.br/tdmc/tde_busca/arquivo.php?codArquivo=148.

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A integração entre o citoesqueleto celular e a MEC mediada pelas integrinas gera a produção de força mecânica sobre a membrana plasmática. Isto permite às células gerar tração durante sua migração e tensão durante o remodelamento da MEC. Várias proteínas com diferentes funções já foram identificadas como ligantes das subunidades a e b das integrinas. O estudo de proteínas capazes de se ligar e interferir na sinalização via integrina, como as desintegrinas-like e cisteina-rich presentes nos venenos de serpente e proteínas conhecidas como ADAM (A Disintegrin And Metaloprotease), torna-se cada vez mais importante. Assim, o isolamento, a caracterização e a determinação da estrutura de várias desintegrinas oferecem valiosas ferramentas para o desenvolvimento de novos compostos terapêuticos para um vasto número de doenças, sendo excelentes candidatos-protótipo para o desenvolvimento de novos fármacos que interfiram nas funções celulares moduladas por proteínas de adesão. Entretanto, as formas como a integrina e a ADAM interagem ainda não foram bem esclarecidas. Neste contexto, este trabalho visa analisar em escalar molecular a estrutura da integrina alpha6beta1 e do domínio desintegrina-like das ADAMs 2 e 9 humanas, e a forma como estas proteínas interagem, aplicando metodologias de biologia computacional estrutural como modelagem e dinâmica molecular. Com o objetivo de estudar a interação destas proteínas, modelos estruturais foram construídos por homologia a partir das estruturas 3D de proteínas obtidas por cristalografia de raio-X, e realizaram-se simulações de dinâmica molecular com solvente explícito para as proteínas isoladas e em complexo. Através do estudo estrutural e funcional pelo método in silico da integrina alpha6beta1 e ADAMs 2 e 9 humanas, as análises dos resultados das simulações e da flutuação dos resíduos de contato entre as duas proteínas durante a dinâmica molecular, foram desenhados e caracterizados novos candidatos peptídicos para inibição da integrina alpha6beta1. Nas simulações da movimentação angular do domínio bA/Hybrid, visando a possível ativação da integrina alpha6beta1 através da interação com o domínio desintegrina-like de ADAM9 e ligantes peptídicos, obtivemos resultados positivos para os peptídeos A9b e A9d. Este estudo aponta para o desenvolvimento de inibidores protéicos viáveis da integrina alpha6beta1 com base nestas estruturas. Nossos resultados ainda comprovam pelas metodologias in silico a eficácia dos modelos construídos, conseguindo reproduzir o comportamento das proteínas em estudo.
The production of mechanical force on plasma membrane is mediated by integrins, connecting ECM components and cell cytoskeleton. This allows cells to generate traction during migration and tension during ECM remodeling. Integrins are membrane-spaning adhesion receptors that mediate dynamic linkages between intracellular actin cytoskeleton and the extracelullar adhesive matrix, outside-in/inside-out signaling, migration and detachment. Several proteins with diferent functions have already been identified as integrin ligands, and some important candidates as disintegrin-like and cystein-rich domains present in the snake venon metalloproteinases and ADAM (A Disintegrin and Metaloprotease) become important as they interfere in cell signaling pathways mediated by these transmembrane receptors. Thus, the isolation, characterization and structure determination of disintegrin-like domains o_er valuable tools for the development of new therapeutic compounds for a wide range of diseases. These compounds may provide new treatments for diseases such as cancer and inflammation pathologies. However, the mechanisms of ADAM-Integrin interaction have not been well clarified, yet. In this perspective, this study aims to analyze the molecular structure of the alfa6beta1 integrin and the disintegrin-like domain of human ADAM2 and ADAM9. Computational biology methods such as homology modeling and molecular dynamics were used in order to study the dynamics of the interaction of these proteins. Using in silico experimentation, detailed models of human alfa6beta1 and human ADAM 2 and 9 were obtained. Based on these models, the molecular basis of alfa6beta1-ADAMdsld interactions was assessed, and the most important structural components in ligand recognition/discrimination were identified. Using the collected structural information, we designed different small peptide based inhibitors, based on the structure of the interaction loop of human ADAM 9 disintegrin-like domain. Here proposed A9a inhibitor was testedin vitro, showing satisfactory results in blocking cell adhesion on specific substrates by alfa6beta1- laminin affnity inhibition in nanomolar concentrations. Our results also show the effcacy of the constructed models, the power of computational biology tools in new drug-design technologies, and clearly suggest that here presented alfa6beta1 inhibitors are good candidates for further development of new therapeutic agents against inflammation pathologies.
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14

Lloyd, Erin Marie. "Abigail Adams." College Park, Md. : University of Maryland, 2004. http://hdl.handle.net/1903/1418.

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Thesis (M.A.) -- University of Maryland, College Park, 2004.
Thesis research directed by: Dept. of History. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
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15

Adams, Thorsten. "Funktionelle Charakterisierung potentieller Pathogenitätsfaktoren aus Pseudomonas aeruginosa mittels biochemischer und evolutiver Methoden." [S.l.] : [s.n.], 2004. http://webdoc.sub.gwdg.de/diss/2005/adams/adams.pdf.

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16

Mongaret, Céline. "Etude du rôle de la protéine ADAM9 et de son isoforme sécrétée dans les processus de migration et d’angiogenèse tumoraux." Thesis, Paris 5, 2012. http://www.theses.fr/2012PA05T054/document.

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L’invasion métastatique des tumeurs humaines est un mécanisme complexe qui repose sur l’acquisition de nouvelles fonctionnalités par les cellules tumorales. Les protéines ADAM et plus particulièrement la protéine ADAM9, grâce à leur domaine extracellulaire se composant d’une activité métalloprotéasique et disintégrine, possèdent des fonctions importantes et nécessaires au processus d’invasion. Cependant, les mécanismes de régulation de la protéine restent globalement méconnus dans la pathologie cancéreuse. L’objectif de ce travail a consisté à évaluer le rôle de l’expression d’ADAM9 dans les mécanismes d’agressivité tumorale tels que l’adhérence cellulaire, la migration cellulaire ou l’angiogénèse ainsi que l’étude des mécanismes de régulation de l’expression de cette protéine. Compte tenu du fait que le peroxyde d’hydrogène est connu pour induire l’expression d’ADAM9, les premiers travaux ont eu pour objectif d’établir le lien entre stress oxydant, ADAM9 et adhérence tumorale. L’exposition des cellules d’adénocarcinome pulmonaire au peroxyde d’hydrogène induit une augmentation dose dépendante de l’expression de la protéine ADAM9 transmembranaire et de sa forme sécrétée. Les études in vitro ont permis d’établir que les capacités d’adhérence et d’invasion tumorale induites par le stress oxydant sont principalement médiées par les deux isoformes de la protéine ADAM9. Par ailleurs, l’expression d’ADAM9 provoque un accroissement de la néo-angiogénèse par l’intermédiaire d’un accroissement non transcriptionel de la biosynthèse d’IL8. Cette cytokine proangiogénique va interagir avec le récepteur CXCR2 et va permettre la mise en place d’une néovascularisation in vitro. Le développement d’un modèle de xénogreffe de cellule d’adénocarcinome pulmonaire a permis de confirmer le rôle majeur d’ADAM9 dans les processus de dissémination métastatique et d’angiogénèse tumoraux. L’étude de la modulation pharmacologique d’ADAM9 a reposé sur deux stratégies pharmacologiques différentes : d’une part l’interaction directe avec les différentes isoformes d’ADAM9 au moyen d’un anticorps neutralisant et d’autre part une action sur les mécanismes de transduction cellulaire tels que la protéine SRC ou la protéine kinase C. Ce travail a permis de mieux comprendre l’implication de la protéine ADAM9 au cours du processus de cancérogenèse de part sa participation aux étapes majeures que sont la dissémination métastatique induite par le stress oxydant et l’angiogenèse
Tumor invasion is a complex mechanism that is based on the acquisition of tumor cells new functions. ADAM proteins, especially protein ADAM9, through their extracellular domain consisting of a disintegrin and metalloprotease activity, have important functions and processes necessary for invasion. However, the mechanisms regulating protein remain largely unknown in cancer pathology. The objective of this work was to evaluate the role of ADAM9 expression in tumor aggressiveness such as cell adhesion, cell migration and angiogenesis and to study the mechanisms regulating this protein expression. Given the fact that hydrogen peroxide is known to induce the expression of ADAM9 protein, the first work aimed to establish the relationship between oxidative stress, adhesion and tumor ADAM9 expression. Hydrogen peroxide induces a dose-dependent increase of both expression and activity of ADAM9 on adenocarcinoma pulmonary cells. Oxidative stress induced ADAM9 expression and activity are mainly supported by the secreted form of ADAM9 protein. In vitro studies have shown that capacity of adhesiveness and invasiveness induced by oxidative stress are mainly mediated by the two forms of ADAM9 protein. In addition, ADAM9 protein expression induces neoangiogenesis through increased production of interleukin 8. This proangiogenic cytokine that interacts with the CXCR2 receptor is able to stimulate neovascularization in vitro studies. Development of a lung adenocarcinoma xenograft model confirmed that ADAM9 protein have an important role on metastasis process and tumor angiogenesis. The study of pharmacological modulation of ADAM9 expression was based on two different pharmacological strategies: the first interacts with different isoforms of ADAM9 using a neutralizing antibody and the second strategy modulate cell transduction mechanism such as SRC protein or protein kinase C (PKC). This work aims to understand the involvement of ADAM9 protein during the process of carcinogenesis, such as tumor invasion induced by oxidative stress and neoangiogenesis
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17

Adami, Julien Dupuy Jérôme Maazouz Abderrahim. "Etudes rhéocinétique et diélectrique de systèmes réactifs à base de polyester insaturé (résines UP) application au suivi en temps réel du processus de polymérisation dans le procédé RTM /." Villeurbanne : Doc'INSA, 2005. http://docinsa.insa-lyon.fr/these/pont.php?id=adami.

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18

Cunningham, Hugh Kern. "Adams house in paradise." Thesis, Georgia Institute of Technology, 1987. http://hdl.handle.net/1853/23291.

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19

Lai, Kenny K. "Adam in Romans 5:12-21 in relation to early Judaism." Online full text .pdf document, available to Fuller patrons only, 2001. http://www.tren.com.

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20

Raventós, Morera Oriol. "Adams Representability in Triangulated Categories." Doctoral thesis, Universitat de Barcelona, 2011. http://hdl.handle.net/10803/682.

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This thesis contains new results about the representability of cohomological functors defined on a subcategory of compact objects (with respect to a fixed cardinal) of a well generated triangulated category. Classical theorems of Adams for the stable homotopy category and Neeman for compactly generated triangulated categories are extended to the first uncountable cardinal. The case of derived categories of rings and the stable motivic category are studied in detail. These results contribute to answering negatively a question raised by Rosický of whether all cohomological functors defined on a subcategory of compact objects with respect to a large enough cardinal are representable. Some of the findings in this thesis are based on new results about abelian categories, the most relevant being a generalization of the Auslander Lemma for non Grothendieck categories.
TESI "Representabilitat d'Adams en categories triangulades"

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En aquesta tesi s'obtenen resultats nous sobre la representabilitat de functors cohomològics definits en subcategories d'objectes compactes (respecte a un cardinal fixat) d'una categoria triangulada ben generada. S'estenen al primer cardinal no numerable teoremes antics d'Adams per a la categoria d'homotopia estable i de Neeman per a categories compactament generades. S'estudien en detall els casos de la categoria derivada d'un anell i la categoria motívica estable. Aquests resultats contribueixen a respondre negativament una pregunta de Rosický sobre si tots els functors cohomològics definits en una subcategoria d'objectes compactes respecte a un cardinal suficientment gran són representables. Alguns dels avenços d'aquesta tesi es basen en nous resultats sobre categories abelianes, el més rellevant dels quals és una generalització del lema d'Auslander per a categories que no són de Grothendieck.
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21

Van, der Colff Margaretha Aletta Adams Douglas. "Douglas Adams : analysing the absurd." Pretoria : [s.n.], 2004. http://upetd.up.ac.za/thesis/available/etd-08212008-183816.

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22

Seweryn, Dariusz. "O wyobraźni lirycznej Adama Mickiewicza /." Warszawa : Instytut Badań Literackich Wydawn, 1996. http://catalogue.bnf.fr/ark:/12148/cb375190148.

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23

Harper, Glenn Allen. "They chose land wisely : historic settlement patterns, agricultural land utilization, and building practices of Mennonite settlers in Southern Adams County, Indiana." Virtual Press, 1987. http://liblink.bsu.edu/uhtbin/catkey/487916.

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Historic rural settlement patterns and agricultural land utilization appear to have been partially influenced by pre-settlement landscape characteristics (especially drainage and soil fertility). Therefore efforts to document, interpret and ultimately protect and manage rural historic resources (sites, structures and objects) must include a broad survey methodology which integrates traditional architectural inventory procedures with natural landscape history and cultural influences.The preliminary findings of a recent rural landscape survey of southern Adams County, Indiana suggest a possible correlation between landscape characteristics and early Swiss Mennonite settlement patterns. While these settlers were probably not cognizant of the region's geologic history, they seem to have had an appreciation and awareness of certain landscape characteristics (elevation, drainage and vegetation as a clue to soils) as an indication of desirable farmland.This creative project uses the preliminary findings of The Southern Adams County Rural Landscape Survey as the basis for an in depth study of the apparent relationship between nature and culture which exists in this locality.The area which is the focus of the project is the historic home of the majority of Amish and Swiss Mennonite settlers in southern Adams County. It includes portions of French, Monroe, Hartford and Wabash Townships and centers on an uneven morainic belt which parallels the northern side of the Wabash River.The goal of the study is to explore the hypothesis generated by the survey, that: natural features and subculture geographic distribution as revealed in building types (the half-timber house, the white frame summer kitchen and the red Sweitzer barn) seem to correlate. The study is not an attempt to prove empirically the relationship between nature and culture. Rather it is an effort to reveal additional information about these variables which might later serve as the basis for analytical models or methodologies for studying other rural, cultural landscapes.
Department of Architecture
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Calvo, Christopher W. "The Adam Smith thesis." FIU Digital Commons, 2002. http://digitalcommons.fiu.edu/etd/1983.

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The object of this thesis is to present a reinterpretation of Adam Smith's philosophy. It works to show the pessimistic character of his thought that is so often overlooked by conventional analyses. The skepticism Smith holds for man can be seen in his theories on the accumulation of knowledge, morality, economics, and human progress. By emphasizing Smith's theory of man's subjugation to the natural order, an alternative interpretation is given of liberal economics. The role of God in Smith's philosophy will be shown to serve two purposes. God serves as Smith's final line of explanation, and it also provides humanity beneficial results through unintended outcomes.
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Smith, Robert W. "Keeping the republic: Ideology and the diplomacy of John Adams, James Madison and John Quincy Adams." W&M ScholarWorks, 1997. https://scholarworks.wm.edu/etd/1539623906.

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This dissertation explores the extent to which the political ideology that formed the basis for the American republic shaped American diplomacy, using John Adams, James Madison and John Quincy Adams as case studies. American statesmen drew on a variety of sources for republican principles of diplomacy. The law of nations and the Scottish political economists supplied the ideas of an international balance of power and freedom of trade. English writers of the Opposition Whig school provided concepts such as political separation from Europe, reliance on a navy for defense, abhorrence of a standing army and, indirectly, the belief that the United States could use its economic power to secure its diplomatic goals.;John Adams began his career with a high degree of confidence in the virtue of the American people and the coercive power of American trade. He combined a classical martial ethic with an Opposition whig strategic sense. Adams's experience in Europe disproved these beliefs, and as president he fell back on the republican realpolitik, based on naval power and separation from Europe, suggested by the Opposition Whig school.;James Madison never held out a classical model of virtue and never lost faith in the coercive power of American commerce. His combination of political economy with Opposition thought led him to reject both an army and a navy as monarchical tools of diplomacy. He saw the Constitution as a vehicle for harnessing American economic power. Madison's conception of a republican diplomacy led him, as secretary of state and president, to rely on the Embargo and similar economic measures.;John Quincy Adams combined republican realpolitik with a sense of Christian purpose and saw American government and diplomacy as a vehicle for moral improvement. Adams's republic rested on a continental union and a diplomacy directed against European colonization, as a manifestation of monarchy. Non-colonization included removing Spain as a neighbor in North America, preventing European political encroachment in the Western Hemisphere, and securing a hemisphere-wide consensus on neutral rights. as a congressman and critic of slavery-driven expansion, Adams demonstrated the persistence of Opposition Whig thought in American politics.
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Peyrer-Heimstätt, Alexandra. "Der Wiener Maler John Quincy Adams /." Wien, 1995. http://bibpurl.oclc.org/web/21555.

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Hammond, Anne. "The landscape photographs of Ansell Adams." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323155.

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Greenlees, J. P. C. "Adams spectral sequences in equivariant topology." Thesis, University of Cambridge, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373251.

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Khan, Halima. "The Republican Thought of Abigail Adams." Thesis, Boston College, 2007. http://hdl.handle.net/2345/558.

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Thesis advisor: Cynthia L. Lyerly
This thesis analyzes the evolution of Abigail Adams's republican thought throughout the course of her life. The transition from a traditional wife of a local lawyer to an articulate and well-informed First Lady can be traced along with the increasing personal hardships she faced in light of the events of the American Revolution and the founding of the United States. Her unique relationship to men leading the Revolution and her own intellectual curiosity led her to a sophisticated understanding of republicanism and a unique interpretation of women's important contributions to the new nation
Thesis (BA) — Boston College, 2007
Submitted to: Boston College. College of Arts and Sciences
Discipline: History
Discipline: College Honors Program
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Rocha, Fábio Sodré. "Desigualdade de Adams em domínios ilimitados." Universidade Federal de Goiás, 2018. http://repositorio.bc.ufg.br/tede/handle/tede/8859.

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Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq
In this work our aim is to present an extension of the Trudinger-Moser inequality [20] in unbounded domains of Rn for Sobolev Spaces involving high order derivatives. This inequality is nowadays known as Adams-type inequality [1]. We study the techniques developed in the works due to F. Sani and B. Ruf in [23] and due to N. Lam and G. Lu in [16] which are, essentially, combinations of the Comparison Principle of Trombetti and Vazquez for polyharmonic operators and a symmetrization argument, also known as Schwarz Symmetrization. "With such techniques in hands", our aim is to reduce our problem to the radial case and, as a consequence, find an upper bound for the supremum over all functions belonging to the unit ball of Wn;mn (Rn) provided with some specific norm, as well as the sharpness of the constant that appears in Adams inequalities.
Neste trabalho temos como objetivo apresentar uma extensão da desigualdade de AdamsTrudinger-Moser [1] em domínios ilimitados de Rn para espaços de Sobolev envolvendo derivadas de ordem superior no caso crítico. Esta desigualdade é conhecida hoje como desigualdade do tipo Adams [1]. Nosso estudo é baseado nas técnicas desenvolvidas nos trabalhos devidos à F. Sani e B. Ruf em [23] e à N. Lam e G. Lu em [16], que são, essencialmente, combinações do Princípio de Comparação de Vazquez-Trombetti para operadores poliharmônicos e um argumento de simetrização, também conhecido como Simetrização de Schwarz. Munidos de tais técnicas, nosso objetivo é reduzir nosso problema ao caso radial, e como consequência, encontrar um limite superior para o supremo sobre todas as funções pertecentes à bola unitária de Wn;mn (Rn) provido de uma norma específica, bem como também mostrar a otimalidade da constante presente na desigualdade do tipo Adams.
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De, Luca Lauren Celeste. "Characterizing ADAM28 function in trophoblast differentiation." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/58515.

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Human placental development is a complex process dependent on continuous cross talk between fetal and maternal uterine compartments. Trophoblasts, placental cells of fetal epithelial lineage, invade the maternal uterine lining, forming the maternal-fetal interface. This interface is vital for controlling nutrient, gas, and waste exchange between maternal and fetal circulatory systems. The differentiation of progenitor trophoblasts into highly-specific cell subsets important for placental function is a highly-regulated developmental process. Trophoblast differentiation into invasive subtypes is essential for enhancing optimal uterine artery physiology, maternal-fetal nutrient exchange, and immunotolerance in pregnancy. Trophoblast invasion is controlled by cell-cell and cell-matrix interactions, as well as through production of various growth factors, cytokines, and hormones. Insufficient trophoblast invasion results in insufficient arterial remodeling that underlies cellular events responsible for the development of pregnancy disorders such as preeclampsia and fetal growth restriction. A Disintegrin and Metalloproteinase 28 (ADAM28) is a multi-functional protein belonging to the metzincin superfamily of metalloproteinases. ADAM28 exists as two alternative splice variants: a full-length transmembrane form (ADAM28-L) and a truncated secreted variant (ADAM28-S). Recently, ADAM28 has been shown to be differentially expressed in two distinct trophoblast subtypes ex vivo; however despite this knowledge, little is known about the role of ADAM28 in placental development or trophoblast biology. My research has demonstrated that both ADAM28 isoforms are highly expressed in invasive trophoblasts of distal regions in placental columns. Utilizing a loss-of-function strategy, I demonstrate that ADAM28 promotes trophoblast column outgrowth, and directs trophoblast cell migration and survival. Collectively, these findings describe a novel role for ADAM28 in regulating the differentiation of progenitor trophoblasts into extravillous trophoblast subsets and highlight ADAM28 as a key protease in human placental development.
Medicine, Faculty of
Experimental Medicine, Division of
Medicine, Department of
Graduate
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32

Trummler, Theresa [Verfasser], Nikolaus A. [Akademischer Betreuer] Adams, Mohamed [Gutachter] Farhat, and Nikolaus A. [Gutachter] Adams. "Numerical investigations of cavitation phenomena / Theresa Trummler ; Gutachter: Mohamed Farhat, Nikolaus A. Adams ; Betreuer: Nikolaus A. Adams." München : Universitätsbibliothek der TU München, 2021. http://d-nb.info/1229620796/34.

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33

Eldridge, Michael David. "Dying Adam with his multiethnic family : understanding the 'Greek life of Adam and Eve'." Thesis, King's College London (University of London), 2000. https://kclpure.kcl.ac.uk/portal/en/theses/dying-adam-with-his-multiethnic-family--understanding-the-greek-life-of-adam-and-eve(6f882d7a-2845-4f54-9594-a81ec2135010).html.

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Eldridge, Michael D. "Dying Adam with his multiethnic family : understanding the "Greek life of Adam and Eve /." Leiden : Brill, 2001. http://catalogue.bnf.fr/ark:/12148/cb388226054.

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35

Hayter, Julia Rose. "The cytodomains of ADAM proteases." Thesis, University of Liverpool, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250457.

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36

Mess, Christina. "Das Vertragsrecht bei Adam Smith." Frankfurt, M. Bern Berlin Bruxelles New York, NY Oxford Wien Lang, 2006. http://d-nb.info/986037834/04.

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37

Souza, Davi de. "Villiers de L´Isle-Adam." Florianópolis, SC, 2011. http://repositorio.ufsc.br/xmlui/handle/123456789/95166.

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Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-Graduação em Literatura, Florianópolis, 2011
Made available in DSpace on 2012-10-25T21:34:58Z (GMT). No. of bitstreams: 1 294465.pdf: 2227513 bytes, checksum: b00032aac70651eb8bdc6764aaf4cf77 (MD5)
A presente tese é fundamentada na obra Tribulat Bonhomet, de Villiers de L'Isle-Adam (1838-1889). Obra composta de quatro contos e uma novela. Tanto a obra quanto o autor permitem muitas reflexões acerca da literatura, desde a literatura de humor até a de horror, mas sobretudo literatura fantástica. E é sobre esta que me detenho, especificamente na novela Claire Lenoir. Como Tribulat Bonhomet permanece inédito em português, apresento uma tradução e sobre essa tradução ? que se encontra ao fim, como anexo ? elaborei minha tese, sobre uma via dupla: tradução e teoria literária. Dedico o Capítulo 1 a essa duplicidade, separadamente, apresentando em 1.1 a literatura fantástica, fazendo o esboço de um tipo de literatura que provoca um exorcismo do real, um afastamento entre o leitor e a realidade. Na seqüência, em 1.2 abordo as perspectivas de tradução de um texto literário, a partir, principalmente, de Friedrich Schleiermacher (1768-1834) e Antoine Berman (1942-1991). Ambos os tópicos servirão de base para os dois capítulos subseqüentes. No Capítulo 2, dedico-me ao processo de tradução do romance, levando em conta as perspectivas abordadas no Capítulo 1.2, fazendo comentários acerca da tradução e comparando-a com outras traduções. Por último, no Capítulo 3, partindo da forma como Villiers de L'Isle-Adam mescla realidade e ficção ? e tomo aí como base o texto traduzido ? retomo os temas esboçados no Capítulo 1.1, da literatura fantástica, para especificar os elementos estranhos que geram o fantástico na obra e provocam um exorcismo do real. A conclusão, portanto, dá-se sobre uma duplicidade: há um exorcismo do real na literatura fantástica; e há um exorcismo do real em Villiers ? mediante a inserção de elementos fantásticos.
Cette thèse est basée sur l'oeuvre Tribulat Bonhomet, de Villiers de L'Isle-Adam (1838-1889). Oeuvre composée de quatre récits et une nouvelle. L'oeuvre et l'auteur permettent de nombreuses réflexions sur la littérature, de la littérature d'humour jusqu´à l'horreur, mais surtout sur la littérature fantastique. Et c'est sur cette dernière que je me pencherai spécifiquement avec la nouvelle Claire Lenoir. Comme Tribulat Bonhomet reste inédite en portugais, je présente une traduction, et c´est sur cette traduction ? qui se trouve en fin de volume en pièce jointe ? que j´ai élaboré ma thèse selon une double voie: la traduction et la théorie littéraire. Je consacre le Chapitre 1 à cette duplicité, séparément, en présentant en 1.1 la littérature fantastique, faisant le croquis d'un type de littérature qui provoque un exorcisme du réel, une distanciation entre le lecteur et la réalité. Ensuite, en 1.2 je discute sur les perspectives de la traduction d'un texte littéraire, à partir, principalement, de Friedrich Schleiermacher (1768-1834) et d'Antoine Berman (1942-1991). Les deux thèmes formeront la base des deux chapitres suivants. Dans le Chapitre 2, je me consacre au processus de traduction de l'oeuvre, en tenant compte des perspectives discutées dans la partie 1.2, en faisant des commentaires concernant la traduction et en la comparant à d'autres traductions. Enfin, au Chapitre 3, à partir de la manière dont Villiers de L'Isle-Adam mélange fiction et réalité ? et je me base ici à partir du texte traduit ? je reprends les thèmes mentionnés dans le Chapitre 1.1, sur la littérature fantastique, en précisant que des éléments étranges génèrent le fantastique dans l'oeuvre et provoquent un exorcisme du réel. La conclusion, donc, se fonde sur une duplicité: il est un exorcisme du réel dans la littérature fantastique, et il est un exorcisme du réel chez Villiers ? par l'inclusion d'éléments fantastiques.
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38

Steinbach, Bernhard. "Cane: the American Adam rekindled." Thesis, Virginia Polytechnic Institute and State University, 1986. http://hdl.handle.net/10919/101152.

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Cane is already recognized as the most significant landmark of the Harlem Renaissance, and as one of the first major contributions to black literature. However, critics have neglected to address its similarities to nineteenth-century American literature, and specifically how it continues a celebrated tradition dedicated to penetrating considerations of American identity. This study attempts to re-focus the critical perspective to illustrate that Cane deserves recognition as a major work of American literature because it calls for an Adamic personality to combat the complexities of the enigmatic American scene. Moreover, the study suggests that Cane belongs among those famous American writings by Emerson, Hawthorne, Whitman, Twain, and Melville because it too investigates the tensions between individuality and social continuity that are so important to an ongoing American dialectic. Finally, the study explains that Cane is in fact worthy of acceptance into the exclusive forum of American writings because ( in Roger Rosenblatt's words) it “is not conceived of in terms of what an individual human being may strive to overcome or accomplish, but rather in terms of where that individual may be spiritually and culturally located.”
M.A.
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39

Campbell, Iain D. "George Adam Smith (1856-1942)." Thesis, University of Edinburgh, 2001. http://hdl.handle.net/1842/18074.

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This study is an intellectual biography of Sir George Adam Smith, biblical scholar and Vice-Chancellor of the University of Aberdeen. Smith trained for the ministry of the Free Church of Scotland under A.B. Davidson, who was influential in disseminating Higher Critical views of the Bible in Scotland. Smith inherited his teacher's penchant for Hebrew and Old Testament criticisms, and served as Hebrew tutor in Aberdeen's Free Church College following the deposition of William Robertson Smith, before becoming the first minister of Queen's Cross Free Church, Aberdeen (1882-92). During his ministry in Aberdeen Smith established a reputation as a preacher of note, and a leading biblical scholar. His preaching drew a large congregation around him, and his Old Testament commentaries secured him a place of note among students of the Old Testament prophets. The tensions between the developing biblical scholarship of the period and the confessional commitment of the Victorian Free Church of Scotland are evident in his years of ministry; and this thesis examines the relationship between the Church's theological position and the scholarship of the rising intellectuals. In 1892 Smith was appointed to the Chair of Hebrew and Old Testament Exegesis at the Free Church College, Glasgow, where he served until 1910. Smith's scholarly work focused on further critical studies of the prophets and the Historical Geography of Palestine. The tensions between academic study of the biblical text and the Church's confessional position came to a head with a near trial for heresy in 1902, the significance of which is examined here. Smith also embraced a social Gospel, and the relationship between his critical study of the Old Testament and his social work in the cities is worthy of study. Some historians view the emergence of a social gospel as evidence of a disappearing orthodox; but for Smith the social work of the church was integral to the ongoing ministry of the Church. Smith served as Principal of Aberdeen University from 1910 to 1935. His position as Vice Chancellor was akin to pastoring a large congregation without credal commitment. The growth of the University during his Principalship is interesting in its own right; not less so are his work as Moderator of the United Free Church of Scotland (1916) and his work in church and state during the First World War.
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40

Williams, Kendra Justine. "Analysis and Characterization of Debris Flows in November, 2006, Mount Adams, Washington." PDXScholar, 2011. https://pdxscholar.library.pdx.edu/open_access_etds/186.

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Debris flows caused by heavy rains occurred in November of 2006 on several Cascade volcanoes. Mt. Adams experienced debris flows in seven of eighteen drainages including Adams Creek, Big Muddy Creek, Lewis Creek, Little Muddy Creek, Muddy Fork, Rusk Creek and Salt Creek. Six debris flows occurred on the northeast side of the mountain. A landslide initiated one debris flow, three were initiated by heavy water flow and in channel landslides, and three were initiated by a coalescence of eroded channels (headless debris flows). Four pre-2006 debris flows were found in the Cascade Creek, Crofton Creek, Hellroaring Creek and Morrison Creek drainages. Every 2006 debris flow initiated in Quaternary glacial drift. Attributes of the drainages were investigated to determine differences between drainages with debris flows and those without. The upper basins of drainages with debris flows averaged 37% glacial coverage, 29% bedrock and 35% unconsolidated material. The upper basins of drainages without debris flows without averaged 12% glacial coverage, 63% bedrock, and 25% unconsolidated material. All of the drainages with debris flows were directly connected to a glacier, opposed to only 36% of the drainages without debris flows. Drainages with debris flows averaged 18% slopes above 33°, 10% vegetation, a gradient of 0.38, a Melton's Ruggedness Number of 0.62, an average annual rainfall of 2.16 m, and -52% glacier lost between 1904-2006. The upper basins of drainages without debris flows averaged 11% slopes above 33°, 18% vegetation, a gradient of 0.31, a MRN of 0.58, an average annual rainfall of 2.38 m, and -41% glacier lost between 1904-2006. A multiple logistic regression was performed to determine factors with highest influence on predicting the probability of a debris flow. Influencing factors were percent glacial coverage and average annual rainfall. They predicted the 2006 debris flows with an 89% accuracy rate. This model was used to produce a debris flow hazard map. Due to the number of Cascade volcanoes that experienced debris flows as a result of the November 2006 storm, data of this type could be combined from multiple mountains to construct a general Cascade Mountain debris flow hazard model.
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41

Kesselmeier, Manfred Rudolf. "Friedrich Wilhelm Adam Sertürner (1783-1841) : Apotheker und Forscher /." Stuttgart : Wissenschaftliche Verlagsgesellschaft, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?u20=9783804724853.

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42

Adams, Theresa A. [Verfasser]. "That strange personal interest / Theresa A. Adams." Münster : Universitäts- und Landesbibliothek Münster, 2006. http://d-nb.info/1141577941/34.

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43

Luski, Michael Gordon. "Harold Adams Innis, the bias of history." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0006/MQ28898.pdf.

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Adams, Marina [Verfasser]. "Geschäftsunfähigkeit und Betreuung in Personengesellschaften / Marina Adams." Baden-Baden : Nomos Verlagsgesellschaft mbH & Co. KG, 2016. http://d-nb.info/1122045921/34.

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45

El, Dsoki Tarik. "Development of the multibody simulation with Adams." Universitätsbibliothek Chemnitz, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-172497.

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Die Mehrkörpersimulation (MKS) kommt in immer mehr Bereichen zum Einsatz. Bis vor einigen Jahren war das Thema fast ausschließlich im Automobilbereich wichtig. Heute wird der Ansatz in fast allen Bereichen der Technik, in dem „Bewegungsabläufe“ eine Rolle spielen, eingesetzt. Im Gegensatz zur Finite Elemente (FE)-Methode, für die eine detaillierte Bauteiltopologie mit einer Vielzahl von Elementen nötig ist, können mit MKS-Systemen selbst komplexe mechanische Systeme mit einer relativ geringen Anzahl an Freiheitsgraden abgebildet werden. Das Programm Adams hat diese Entwicklung maßgeblich mit gestaltet. Neben den Erweiterungen im Bereich der Solver und anderer mathematischer Formulierungen war immer die einfache Benutzerführung, die Integration von weiteren Simulationstechnologien und auch die Entwicklung von Spezialanwendungen ein wichtiges Thema der Entwicklung. Im Rahmen dieses Vortrages wird der Einsatz von Adams an Hand von Beispielen demonstriert. Weiterer Schwerpunkt ist die Erweiterung der Modelle durch Berücksichtigung der elastischen Materialeigenschaften einzelner Bauteile. Die Kopplung zur Lebensdauerberechnung an Hand von Beispielen schließt den Beitrag ab.
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Klinkenberg, Michael F. "Das idealistische Theater Villiers de l'Isle-Adams /." Münster ; Hamburg ; London : Lit, 2002. http://catalogue.bnf.fr/ark:/12148/cb38996046n.

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47

Adams, Jeffrey Matthew. "Validation of the Adams Influence Model (AIM)." Thesis, Boston College, 2008. http://hdl.handle.net/2345/613.

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Thesis advisor: Dorothy A. Jones
Understanding Chief Nurse Executive (CNE) influence is essential for the discipline of nursing. There are approximately 5000 CNEs in the United States, all are tasked with being the primary identifiable leader representing organizations in which they are employed and the nursing profession of which they are a part. In this capacity, the CNE is the gatekeeper for the advancement of the majority of the 2.4 million nurses practicing in the U.S. Literature suggests that early CNEs lacked influence and often were not recognized members of organizational executive teams. Today, after two decades of struggle, CNEs are identified as essential executive team members. However, they still self identify as being less influential than their C-suite counterparts, leaving us to question, "Having gotten to the table, now what?" This study was designed as an initial step toward answering this question through Validation of the Adams Influence Model (AIM). The AIM is a framework that can be used to understand the influence of the CNE in the acute care setting. The study exposed the AIM to a qualitative data set collected as part of an academic medical center's Survey of the Professional Practice Environment. Directed content analysis was used to categorize survey responses and identify influence content toward validation and refinement of the AIM's operational definitions. Study results validated AIM influence factors and influence attributes with some refinement. In addition to development of a refined AIM, study findings also helped identify continued research opportunities. These research potentials included the exploration of; influence instrument development, the influence process, differences between influence and power, and the relationship between CNE influence, practice/ work environments and patient outcomes. As a discipline, nursing must continue to understand the influence of the CNE. These individuals are leading the profession, at what pace and in what direction cannot be left to chance
Thesis (PhD) — Boston College, 2008
Submitted to: Boston College. Connell School of Nursing
Discipline: Nursing
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48

Gowthaman, Rahul, and Suhail Jagwani. "Advanced bushing script program in MSC ADAMS." Thesis, KTH, Fordonsdynamik, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-243489.

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The thesis focuses on investigating and optimizing a bushing script implemented as a tool in MSC ADAMS/Car. The study provides an insight on the representation of a rubber bushing and identify parameters which can be used to define the properties of a bushing in a simulation environment such as ADAMS/Car. The tool being studied here can be used to implement different kind of bushings such as a hydro bushing and a general rubber bushing, but optimization was implemented for the rubber bushing only. With an increasing reliance on Computer Aided Engineering (CAE) tools in the designing process, it is necessary that the vehicle behaviour can be predicted without relying on physical testing. CAE tools reduces the need of prototypes and provides a faster approach to designing vehicles. MSC ADAMS/Car is one such tool, which has been used here to predict the vehicle dynamic behaviour, which will influence the ride, handling and comfort characteristics of the vehicle. Rubber bushings, which have been studied here, have a significant contribution to the overall stiffness of the vehicle and as such, it is imperative that the tool being used here, is accurate and makes the designing process easy. The rubber bushing can be imagined to be a combination of a non-linear elastic spring, a frequency dependent Maxwell component and an amplitude dependent frictional element. In order to ease the design of the bushing properties, a reduced number of input properties are used to calculate the bushing properties internally. While trying to validate the force hysteresis loop obtained through the model with the measured data, it was seen that the accuracy was quite poor for the model when loading it with dynamic loads corresponding to amplitudes of0.2 mm and lower. The quasi-static loading and dynamic loading above 0.2 mm is shown to have a satisfactory accuracy when compared to the measured data.
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49

Juriga, Jakub. "Virtuální model části obráběcího stroje v ADAMS." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2012. http://www.nusl.cz/ntk/nusl-230395.

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In theoretical part, this master´s thesis deals with vibrations in cutting machine and description of creation of self-excited vibrations theory. In practical part, there is problem of chatter in cutting machine solved with using simulation program Adams and computing program MATLAB. Gradually, Multi body system of cutting machine and model of cutting tool with features flexible body are analyzed. At the end all both models were used to create complex model of the cutting machine .
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50

Foriška, Aleš. "Simulační modelování mechatronické soustavy manipulátoru v ADAMS." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2012. http://www.nusl.cz/ntk/nusl-230396.

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This thesis deals with the simulation modelling of manipulator mechatronic system in ADAMS. The beginning of thesis is dedicated to the theoretical study of the compute modelling electro-mechanical systems and mechatronics approach modelling manipulator’s systems. Next chapters describe the creation of kinematics model of the manipulator with using ADAMS and proposal supporting frame in ANSYS/Workbench environment. The next step, manipulator and supporting frame simulation model is created for the computing vibration a dynamic analysis. At the end of this thesis is used cosimulation ADAMS and Matlab/Simulink for the control of synchronous drivers of manipulator.
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