Relevant bibliographies by topics / Adaptive clinical trials

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Adaptive clinical trials'

Author: Grafiati
Published: 22 February 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Adaptive clinical trials.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Adaptive clinical trials"

1

Coffey, Christopher S., and John A. Kairalla. "Adaptive Clinical Trials." Drugs in R & D 9, no. 4 (2008): 229–42. http://dx.doi.org/10.2165/00126839-200809040-00003.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Antonijevic, Zoran. "Adaptive Clinical Trials." Clinical Investigation 5, no. 4 (2015): 353–54. http://dx.doi.org/10.4155/cli.15.20.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Marchenko, Olga, Valerii Fedorov, J. Jack Lee, Christy Nolan, and José Pinheiro. "Adaptive Clinical Trials." Therapeutic Innovation & Regulatory Science 48, no. 1 (2014): 20–30. http://dx.doi.org/10.1177/2168479013513889.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Gokhale, Sanjay G., and Sankalp Gokhale. "Shuffling Adaptive Clinical Trials." American Journal of Therapeutics 23, no. 3 (2016): e663-e669. http://dx.doi.org/10.1097/mjt.0b013e31827e978a.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Fillion, Nicolas. "Clinical Equipoise and Adaptive Clinical Trials." Topoi 38, no. 2 (2018): 457–67. http://dx.doi.org/10.1007/s11245-018-9540-x.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Giovagnoli, Alessandra. "The Bayesian Design of Adaptive Clinical Trials." International Journal of Environmental Research and Public Health 18, no. 2 (2021): 530. http://dx.doi.org/10.3390/ijerph18020530.

Full text
Abstract:
This paper presents a brief overview of the recent literature on adaptive design of clinical trials from a Bayesian perspective for statistically not so sophisticated readers. Adaptive designs are attracting a keen interest in several disciplines, from a theoretical viewpoint and also—potentially—from a practical one, and Bayesian adaptive designs, in particular, have raised high expectations in clinical trials. The main conceptual tools are highlighted here, with a mention of several trial designs proposed in the literature that use these methods, including some of the registered Bayesian ada
APA, Harvard, Vancouver, ISO, and other styles
7

Giovagnoli, Alessandra. "The Bayesian Design of Adaptive Clinical Trials." International Journal of Environmental Research and Public Health 18, no. 2 (2021): 530. http://dx.doi.org/10.3390/ijerph18020530.

Full text
Abstract:
This paper presents a brief overview of the recent literature on adaptive design of clinical trials from a Bayesian perspective for statistically not so sophisticated readers. Adaptive designs are attracting a keen interest in several disciplines, from a theoretical viewpoint and also—potentially—from a practical one, and Bayesian adaptive designs, in particular, have raised high expectations in clinical trials. The main conceptual tools are highlighted here, with a mention of several trial designs proposed in the literature that use these methods, including some of the registered Bayesian ada
APA, Harvard, Vancouver, ISO, and other styles
8

Nirmalan, PraveenK. "Adaptive designs for clinical trials." Kerala Journal of Ophthalmology 33, no. 1 (2021): 29. http://dx.doi.org/10.4103/kjo.kjo_202_20.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Bowalekar, Suresh. "Adaptive designs in clinical trials." Perspectives in Clinical Research 2, no. 1 (2011): 23. http://dx.doi.org/10.4103/2229-3485.76286.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Srivastava, Vartika, Sougata Sarkar, and Chaitali Patanayak. "Adaptive designs in clinical trials." Journal of Pharmacology and Pharmacotherapeutics 11, no. 4 (2020): 129. http://dx.doi.org/10.4103/jpp.jpp_79_20.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Dissertations / Theses on the topic "Adaptive clinical trials"

1

Zhang, Yifan. "Bayesian Adaptive Clinical Trials." Thesis, Harvard University, 2014. http://nrs.harvard.edu/urn-3:HUL.InstRepos:13070079.

Full text
Abstract:
Bayesian adaptive designs are emerging as popular approach to develop adaptive clinical trials. In this dissertation, I describe the mathematical steps for computing the theoretical optimal adaptive designs in biomarker-integrated trials and in trials with survival outcomes. Section 1 discusses the optimal design in personalized medicine. The optimal design maximizes the expected trial utility given any pre-specified utility function, though the discussion here focuses on maximizing responses within a given patient horizon. This work provides absolute benchmark for the evaluation of trial des
APA, Harvard, Vancouver, ISO, and other styles
2

Márquez, Elsa Valdés. "Inference in covariate-adaptive clinical trials." Thesis, University of Sheffield, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425222.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Burnett, Thomas. "Bayesian decision making in adaptive clinical trials." Thesis, University of Bath, 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.760912.

Full text
Abstract:
The key original contribution of this work is the use of a Bayes optimisation framework for the decision made at the interim analysis of Adaptive Enrichment trials. Adaptive Enrichment designs make efficient use of pre-identified patient sub-populations. They begin by recruiting from all eligible patients, then at a pre-planned interim analysis select which sub-populations will be recruited from for the remainder of the sample. We ensure strong control of the Familywise Error Rate whichever sub-populations are selected by constructing an overall hypothesis testing structure using both closed t
APA, Harvard, Vancouver, ISO, and other styles
4

Bari, Wasimul. "Analyzing binary longitudinal data in adaptive clinical trials /." Internet access available to MUN users only, 2003. http://collections.mun.ca/u?/theses,167453.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Bailey, Stuart Michael. "Sequential adaptive designs for early phase clinical trials." Thesis, University of Sussex, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.445626.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Morgan, Caroline Claire. "Group sequential response adaptive designs for clinical trials." Thesis, University of Sussex, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288791.

Full text
Abstract:
A recently developed group-sequential response-adaptive design to compare two treatments with immediate normally distributed responses and known variances is considered. The power function of the test is the same as that under non-adaptive sampling, and significant decreases in the inferior treatment number can be achieved with only minor increases in the average sample number. Reasonably accurate corrected confidence intervals for both the treatment mean difference and the individual means are obtained by constructing approximately pivotal quantities. An approximation to the bias of the maxim
APA, Harvard, Vancouver, ISO, and other styles
7

Temple, Jane Ruth. "Adaptive designs for dose-finding trials." Thesis, University of Bath, 2012. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.564007.

Full text
Abstract:
The pharmaceutical industry is currently facing an industry wide problem of high attrition rates for new compounds and rising development costs. As a result of this, there is an emphasis on making the development process more ecient. By learning more about new compounds in the early stages of development, the aim is to stop ineective compounds earlier and improve dose selection for compounds that progress to phase III. One approach to this is to use adaptive designs. The focus of this thesis is on response adaptive designs within phase IIb dose-finding studies. We explore adapting the subject
APA, Harvard, Vancouver, ISO, and other styles
8

Stacey, Andrew W. "An Adaptive Bayesian Approach to Bernoulli-Response Clinical Trials." CLICK HERE for online access, 2007. http://contentdm.lib.byu.edu/ETD/image/etd2065.pdf.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Xu, Jiajing, and 徐佳静. "Two-stage adaptive designs in early phase clinical trials." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/202252.

Full text
Abstract:
The primary goal of clinical trials is to collect enough scientific evidence for a new intervention. Despite the widespread use of equal randomization in clinical trials, response-adaptive randomization has attracted considerable interest in terms of ethical concerns. In this thesis, delayed response problems and innovative designs for cytostatic agents in oncology clinical trials are studied. There is typically a prerun of equal randomization before the implementation of response-adaptive randomization, while it is often not clear how many subjects are needed in this prephase, and in pract
APA, Harvard, Vancouver, ISO, and other styles
10

Rojas, Cordova Alba Claudia. "Resource Allocation Decision-Making in Sequential Adaptive Clinical Trials." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/86348.

Full text
Abstract:
Adaptive clinical trials for new drugs or treatment options promise substantial benefits to both the pharmaceutical industry and the patients, but complicate resource allocation decisions. In this dissertation, we focus on sequential adaptive clinical trials with binary response, which allow for early termination of drug testing for benefit or futility at interim analysis points. The option to stop the trial early enables the trial sponsor to mitigate investment risks on ineffective drugs, and to shorten the development time line of effective drugs, hence reducing expenditures and expediting p
APA, Harvard, Vancouver, ISO, and other styles

Books on the topic "Adaptive clinical trials"

1

Adaptive and flexible clinical trials. CRC Press, 2012.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
2

Ondra, Thomas. Optimized Response-Adaptive Clinical Trials. Springer Fachmedien Wiesbaden, 2015. http://dx.doi.org/10.1007/978-3-658-08344-1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Bayesian adaptive methods for clinical trials. Chapman & Hall/CRC, 2011.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
4

Mark, Chang, ed. Adaptive design methods in clinical trials. 2nd ed. Taylor & Francis, 2012.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
5

F, Rosenberger William, ed. The theory of response-adaptive randomization in clinical trials. John Wiley & Sons, 2006.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
6

Mark, Chang, ed. Adaptive design methods in clinical trails. Chapman & Hall/CRC, 2007.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
7

Clinical trial design: Bayesian and frequentist adaptive methods. John Wiley & Sons, 2012.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
8

Modern adaptive randomized clinical trials: Statistical and practical aspects. Taylor & Francis, 2015.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
9

Wassmer, Gernot, and Werner Brannath. Group Sequential and Confirmatory Adaptive Designs in Clinical Trials. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-32562-0.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Hu, Feifang, and William F. Rosenberger. The Theory of Response-Adaptive Randomization in Clinical Trials. John Wiley & Sons, Inc., 2006. http://dx.doi.org/10.1002/047005588x.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Book chapters on the topic "Adaptive clinical trials"

1

Gilbert, Peter R. "Adaptive Clinical Trials." In Clinical Trials in the Neurosciences. KARGER, 2009. http://dx.doi.org/10.1159/000209478.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Proschan, Michael A., and Julian Barreiro-Gomez. "Adaptive Methods." In Statistical Thinking in Clinical Trials. Chapman and Hall/CRC, 2021. http://dx.doi.org/10.1201/9781315164090-11.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Cheng, Yi, and Donald A. Berry. "Optimal designs for clinical trials in stages." In Adaptive designs. Institute of Mathematical Statistics, 1995. http://dx.doi.org/10.1214/lnms/1215451482.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Zhang, Lanju, and William F. Rosenberger. "Adaptive Randomization in Clinical Trials." In Design and Analysis of Experiments. John Wiley & Sons, Inc., 2012. http://dx.doi.org/10.1002/9781118147634.ch7.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Freidlin, Boris, and Edward L. Korn. "Adaptive Phase II Trials." In Principles and Practice of Clinical Trials. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-319-52677-5_276-1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Freidlin, Boris, and Edward L. Korn. "Adaptive Phase II Trials." In Principles and Practice of Clinical Trials. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-319-52636-2_276.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Barry, William T. "Adaptive Designs." In Textbook of Clinical Trials in Oncology. Chapman and Hall/CRC, 2019. http://dx.doi.org/10.1201/9781315112084-6.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Ondra, Thomas. "Markov Decision Problems and Clinical Trials." In Optimized Response-Adaptive Clinical Trials. Springer Fachmedien Wiesbaden, 2014. http://dx.doi.org/10.1007/978-3-658-08344-1_4.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Ondra, Thomas. "Introduction to Markov Decision Problems." In Optimized Response-Adaptive Clinical Trials. Springer Fachmedien Wiesbaden, 2014. http://dx.doi.org/10.1007/978-3-658-08344-1_1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Ondra, Thomas. "Finite Horizon Markov Decision Problems." In Optimized Response-Adaptive Clinical Trials. Springer Fachmedien Wiesbaden, 2014. http://dx.doi.org/10.1007/978-3-658-08344-1_2.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Adaptive clinical trials"

1

Dubis, Adam M., Mariya Moosajee, and John Greenwood. "The Use of Adaptive Optics Imaging for Clinical Trials." In Adaptive Optics: Analysis, Methods & Systems. OSA, 2020. http://dx.doi.org/10.1364/aoms.2020.oth5b.1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Lei Cao and Jian Tao. "One optimal adaptive design in clinical trials." In 2010 International Conference on Computer, Mechatronics, Control and Electronic Engineering (CMCE 2010). IEEE, 2010. http://dx.doi.org/10.1109/cmce.2010.5609914.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

MILLER, E. R. "IMPLEMENTATION OF ADAPTIVE RANDOMIZATIONS FOR CLINICAL TRIALS." In Proceedings of the 5th International ISAAC Congress. WORLD SCIENTIFIC, 2009. http://dx.doi.org/10.1142/9789812835635_0138.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

"Approximation Methods for Determining Optimal Allocations in Response Adaptive Clinical Trials." In International Conference on Operations Research and Enterprise Systems. SCITEPRESS - Science and and Technology Publications, 2014. http://dx.doi.org/10.5220/0004909504600465.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

BAI, Z. D., FEIFANG HU, and WILLIAM F. ROSENBERGER. "ASYMPTOTIC PROPERTIES OF ADAPTIVE DESIGNS FOR CLINICAL TRIALS WITH DELAYED RESPONSE." In Proceedings of the Conference in Honor of Professor Zhidong Bai on His 65th Birthday. WORLD SCIENTIFIC, 2008. http://dx.doi.org/10.1142/9789812793096_0017.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Xiao, Liang, Andrew Peet, Paul Lewis, et al. "An Adaptive Security Model for Multi-agent Systems and Application to a Clinical Trials Environment." In 31st Annual International Computer Software and Applications Conference - Vol. 2 - (COMPSAC 2007). IEEE, 2007. http://dx.doi.org/10.1109/compsac.2007.55.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Koo, Bonsung, and Alexander Leonessa. "An Adaptive Block Backstepping Control Design for Functional Electrical Stimulation of Agonist-Antagonist Muscles." In ASME 2011 Dynamic Systems and Control Conference and Bath/ASME Symposium on Fluid Power and Motion Control. ASMEDC, 2011. http://dx.doi.org/10.1115/dscc2011-6143.

Full text
Abstract:
In this paper, an adaptive block backstepping controller is developed for stimulation of agonist-antagonist muscles by using Functional Electrical Stimulation (FES). FES is an alternative method that stimulates a paralyzed muscle in lieu of inactive motor neurons, which was first implemented in the 1960s ([1]). However, many challenges need to be addressed before clinical trials with Spinal Cord Injury (SCI) patients can be performed, which include designing a controller, modeling muscles, developing interface equipment, just to mention a few. To contribute to the FES control field, a nonlinea
APA, Harvard, Vancouver, ISO, and other styles
8

Roth, M. D., D. Khanna, D. P. Tashkin, E. J. Bernstein, C. Spino, and Scleroderma Lung Study III Investigators. "Combination Therapy Trials for Scleroderma-Related Interstitial Lung Disease: Initial and Adaptive Trial Aspects of Scleroderma Lung Study III in the Setting of a Rapidly Changing Clinical Environment." In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1024.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Lu, Xiaofeng. "Adaptive Design Practice in Clinical Trial." In 2020 International Conference on Public Health and Data Science (ICPHDS). IEEE, 2020. http://dx.doi.org/10.1109/icphds51617.2020.00084.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Smith, Steven, Lynsey Gillespie, Liam Heaney, et al. "Adapting asthma clinical trials in response to the COVID-19 pandemic - the BenRex study design." In ERS International Congress 2021 abstracts. European Respiratory Society, 2021. http://dx.doi.org/10.1183/13993003.congress-2021.pa1108.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Reports on the topic "Adaptive clinical trials"

1

Zhang, Cheng, and Yue Yang. Impact of adaptive design on reducing the duration of clinical trials in rare cancers: a meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.2.0081.

Full text
Abstract:
Review question / Objective: Whether the application of adaptive design in clinical trials of rare cancers can shorten the duration of clinical trials? Condition being studied: Currently, the development of innovative drug products (InMPs) for rare cancers faces many challenges, including the difficulty of enrolling sufficient numbers of patients from small and heterogeneous patient populations for clinical trials, and the significant risks of high financial investment, long development times and potential failure from a pharmaceutical company's perspective for rare cancer drugs due to limited
APA, Harvard, Vancouver, ISO, and other styles
2

Chaudhuri, Shomesh, Andrew Lo, Danying Xiao, and Qingyang Xu. Bayesian Adaptive Clinical Trials for Anti‐Infective Therapeutics during Epidemic Outbreaks. National Bureau of Economic Research, 2020. http://dx.doi.org/10.3386/w27175.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Rosenblum, Michael, Jon Arni Steingrimsson, and Josh Betz. New Methods and Software for Designing Adaptive Clinical Trials of New Medical Treatments. Patient-Centered Outcomes Research Institute® (PCORI), 2019. http://dx.doi.org/10.25302/10.2019.me.130603198.

Full text
APA, Harvard, Vancouver, ISO, and other styles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography