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1

Shlomo, Samueloff, and Yousef Mohamed K, eds. Adaptive physiology to stressful environments. CRC Press, 1987.

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2

Kamenskaya, Valentina, and Leonid Tomanov. The fractal-chaotic properties of cognitive processes: age. INFRA-M Academic Publishing LLC., 2020. http://dx.doi.org/10.12737/1053569.

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In the monograph the literature information about the nature of stochastic processes and their participation in the work of the brain and human behavior. Established that the real cognitive processes and mental functions associated with the procedural side of external events and the stochastic properties of the internal dynamics of brain systems in the form of fluctuations of their parameters, including cardiac rhythm generation and sensorimotor reactions. Experimentally proved that the dynamics of the measured physiological processes is in the range from chaotic regime to a weakly determinist
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3

Wagner, Carsten A., and Olivier Devuyst. Renal acid–base homeostasis. Edited by Robert Unwin. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0024.

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The kidney is central to acid–base homeostasis. Major processes are reabsorption of filtered bicarbonate, de novo synthesis of bicarbonate from ammoniagenesis, and net excretion of protons. The latter requires buffers such as ammonium, phosphate, citrate and other bases binding protons (so-called titratable acids). The proximal tubule is the major site of bicarbonate reabsorption and only site of ammoniagenesis. The thick ascending limb and the distal convoluted tubule handle ammonia/ammonium and complete bicarbonate reabsorption. The collecting duct system excretes protons and ammonium, but m
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4

Cohen, Hagit, and Joseph Zohar. The Role of Glucocorticoids in the (Mal)adaptive Response to Traumatic Experience. Edited by Charles B. Nemeroff and Charles R. Marmar. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190259440.003.0038.

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Glucocorticoids (GCs) play a major role in orchestrating the complex physiological and behavioral reactions essential for the maintenance of homeostasis. These compounds enable the organism to prepare for, respond to, and cope with the acute demands of physical and emotional stressors and enable a faster recovery with passage of the threat. A timely and an appropriate GC release commensurate with stressor severity enables the body to properly contain stress responses so as to promote recovery by rapidly restoring homeostasis. Inadequate GC release following stress not only delays recovery by d
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5

Wise, Matt, and Paul Frost. Nutritional support in the critically ill. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0334.

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Major injury evokes a constellation of reproducible hormonal, metabolic, and haemodynamic responses which are collectively termed ‘the adaptive stress response’. The purpose of the adaptive stress response is to facilitate tissue repair and restore normal homeostasis. If critical illness is prolonged, the adaptive stress response may become maladaptive, in essence exerting a parasitic effect leaching away structural proteins and impairing host immunity. Primarily therapy should be directed towards the underlying illness, as nutritional support per se will not reverse the stress response and it
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6

Eljaafari, Assia, and Pierre Miossec. Cellular side of acquired immunity (T cells). Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0049.

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The adaptive T-cell response represents the most sophisticated component of the immune response. Foreign invaders are recognized first by cells of the innate immune system. This leads to a rapid and non-specific inflammatory response, followed by induction of the adaptive and specific immune response. Different adaptive responses can be promoted, depending on the predominant effector cells that are involved, which themselves depend on the microbial/antigen stimuli. As examples, Th1 cells contribute to cell-mediated immunity against intracellular pathogens, Th2 cells protect against parasites,
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7

Dörner, Thomas, and Peter E. Lipsky. Cellular side of acquired immunity (B cells). Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0050.

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B cells have gained interest in rheumatoid arthritis (RA) beyond being the precursors of antibody-producing plasma cells since they are also a broader component of the adaptive immune system. They are capable of functioning as antigen-presenting cells for T-cell activation and can produce an array of cytokines. Disturbances of peripheral B-cell homeostasis together with the formation of ectopic lymphoid neogenesis within the inflamed synovium appears to be a characteristic of patients with RA. Enhanced generation of memory B cells and autoreactive plasma cells producing IgM-RF and ACPA-IgG ant
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8

Berntson, Gary G., Peter J. Gianaros, and Manos Tsakiris. Interoception and the autonomic nervous system: Bottom-up meets top-down. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198811930.003.0001.

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Although the efferent role of the autonomic nervous system (ANS) in homeostasis has long been recognized, afferent aspects of the ANS—especially interoception—are increasingly recognized to be equally important. Interoception is fundamental to the regulation of internal physiology, particularly as it is coordinated with contextually determined and adaptive behavioral processes. A cardinal but often underappreciated feature of interoception is its role in myriad cognitive and affective processes that are integrated in health and disease. This chapter introduces the concept of interoception and
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9

Thomas, Ranjeny, and Andrew P. Cope. Pathogenesis of rheumatoid arthritis. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0109.

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In depth molecular and cellular analysis of synovial tissue and fluid from patients with rheumatoid arthritis has provided important insights into understanding disease pathogenesis. Advances in the 1980s and 1990s included modern cloning strategies, sensitive and specific assays for inflammatory mediators, production of high-affinity neutralizing monoclonal antibodies, advances in flow cytometry, and gene targeting and transgenic strategies in rodents. In the 21st century, technological platforms offer unparalleled opportunities for systematic and unbiased interrogation of the disease process
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10

McDermid, Robert C., and Sean M. Bagshaw. Physiological Reserve and Frailty in Critical Illness. Oxford University Press, 2014. http://dx.doi.org/10.1093/med/9780199653461.003.0028.

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Physicians have long sought to define a ‘physiologic age’ distinct from chronologic age which might account for some of the variance in response to critical illness and injury. This has led to the concept of ‘physiologic reserve’ which might represent a major driver of outcome in patients requiring intensive care. The human body is a complex system that adapts to a multitude of external stressors; however, senescence or illness can reduce inherent adaptive mechanisms, reducing complexity and reducing the threshold for decompensation (i.e. acute illness or injury). This theoretical critical thr
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11

Kočan, Ladislav, Dušan Rybár, and Róbert Rapčan. Applications of the Autonomic Nervous System in Clinical Practice. Univerzita Pavla Jozefa Šafárika, Vydavateľstvo ŠafárikPress, 2024. http://dx.doi.org/10.33542/ans-0312-8.

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The autonomic nervous system is a vital component of the peripheral nervous system, responsible for maintaining homeostasis and regulating internal processes within the body. Unlike the voluntary control exerted by the central nervous system, the autonomic nervous system operates involuntarily, innervating smooth organs, vessels, skin glands, and even exerting some influence over skeletal muscles in connection with vegetative functions such as breathing, digestion, and the urinary and gonadal systems. Its impact extends crucially to the cardiac muscles of the heart and plays a significant role
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12

Herbert, Beate M., and Olga Pollatos. The relevance of interoception for eating behavior and eating disorders. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198811930.003.0009.

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The importance of interoception for adaptive and maladaptive behavior, as well as for psychopathology, has gained growing interest, and dysfunctional interoception has been recognized as representing a core impairment across psychosomatic and psychiatric disorders. Eating is intrinsically guided by interoceptive signals and is directly associated with homeostatic psychophysiological needs, well-being, and survival. This chapter provides conceptually and empirically drawn conclusions focusing on the relevance of distinguishable dimensions of interoception for shaping eating behavior and body we
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13

Young, Allan H., and Mario F. Juruena. Hypothalamic–pituitary–adrenal axis. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198789284.003.0006.

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Increased adrenocortical secretion of hormones, primarily cortisol in depression, is one of the most consistent findings in neuropsychiatry. The maintenance of the internal homeostatic state of an individual is facilitated by the ability to circulate glucocorticoids to exert negative feedback on the secretion of hypothalamic–pituitary–adrenal (HPA) hormones through binding to mineralocorticoid and glucocorticoid receptors, thus limiting the vulnerability to diseases related to psychological stress in genetically predisposed individuals. The HPA axis response to stress can be thought of as a cr
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14

Ieropoulos, Ioannis A., Pablo Ledezma, Giacomo Scandroglio, Chris Melhuish, and John Greenman. Energy and metabolism. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780199674923.003.0006.

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Energy resulting from metabolism is essential for any living system—from single-cell to multicellular organisms. This also applies to symbiotic robots (SymBots), which function utilizing the energy (electricity) generated by living microorganisms. In the context of living technologies, artificial symbiosis between the living and the artificial entities of the machine becomes vital for the whole system. If the living entity stops generating energy, the mechatronic system ceases to work yet it is the mechatronic system that provides the microbes with food, and gets rid of their waste. This chapt
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15

Fleckenstein, Alexa. The Benefits of Water Therapy for Sexual and Pelvic Problems (DRAFT). Edited by Madeleine M. Castellanos. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190225889.003.0022.

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Hydrotherapy holds promise for certain sexual and pelvic problems: Water that hits the skin acts on the entire body, triggering the neuro-endocrine-immune system, the brain, the gut-brain, and the autonomic nervous system—the neuro-endocrine axis. Hormesis (regular application of small toxic events or stressors leading to adaption and invigoration) is the mechanism that balances physiological and biochemical processes, including sexuality. Water applications result in homeostasis (balancing of internal systems—such as temperature, electrolytes, and hormones) and invigoration (strengthening of
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